Bicycle Therapeutics (BCYC)

Cash burn rate (est.)	Burn method: Change in cash		Burn method: Operating income		Burn method: FCF (opex + capex)
	Last Q	Avg 4Q	Last Q	Avg 4Q	Last Q	Avg 4Q
Cash on hand (at last report)	648.87 mm	648.87 mm	648.87 mm	648.87 mm	648.87 mm	648.87 mm
Cash burn (monthly)	24.38 mm	20.21 mm	21.85 mm	24.17 mm	23.72 mm	19.98 mm
Cash used (since last report)	84.93 mm	70.42 mm	76.13 mm	84.21 mm	82.66 mm	69.61 mm
Cash remaining	563.94 mm	578.45 mm	572.74 mm	564.66 mm	566.21 mm	579.27 mm
Runway (months of cash)	23.1	28.6	26.2	23.4	23.9	29.0

Beta Read what these cash burn values mean

Financial data from company earnings reports.

Institutional ownership, Q4 2024

BCYC institutional ownership history Ownership history

72.1% owned by funds/institutions

13F holders	Current	Prev Q	Change
Total holders	103	110	-6.4%
Opened positions	17	17	–
Closed positions	24	19	+26.3%
Increased positions	29	35	-17.1%
Reduced positions	35	32	+9.4%

13F shares	Current	Prev Q	Change
Total value	542.87 bn	825.40 bn	-34.2%
Total shares	49.93 mm	45.03 mm	+10.9%
Total puts	17.40 k	24.60 k	-29.3%
Total calls	4.10 k	39.60 k	-89.6%
Total put/call ratio	4.2	0.6	+583.2%

Largest owners	Shares	Value	Change
Baker Bros. Advisors	10.89 mm	$152.39 bn	+15.8%
Point72 Asset Management	4.55 mm	$63.77 bn	+406.2%
Forbion Growth Opportunities Fund II Cooperatief U.A.	3.45 mm	$50.68 mm	NEW
FCPM Iii Services B.V.	3.45 mm	$48.33 bn	+47.5%
Westfield Capital Management	2.61 mm	$36.54 bn	+41.0%
Armistice Capital	2.20 mm	$30.74 bn	+12.3%
Siren, L.L.C.	1.84 mm	$25.75 bn	NEW
T. Rowe Price	1.59 mm	$22.19 mm	-8.0%
SVLSF V	1.56 mm	$54.41 mm	0.0%
GSK GSK	1.53 mm	$39.40 mm	0.0%

Largest transactions	Shares	Bought/sold	Change
Point72 Asset Management	4.55 mm	+3.66 mm	+406.2%
Forbion Growth Opportunities Fund II Cooperatief U.A.	3.45 mm	+3.45 mm	NEW
Deep Track Capital	1.28 mm	-2.27 mm	-64.0%
Siren, L.L.C.	1.84 mm	+1.84 mm	NEW
Baker Bros. Advisors	10.89 mm	+1.49 mm	+15.8%
Ra Capital Management	1.09 mm	-1.16 mm	-51.5%
FCPM Iii Services B.V.	3.45 mm	+1.11 mm	+47.5%
Polar Capital	0.00	-1.00 mm	EXIT
First Light Asset Management	0.00	-967.01 k	EXIT
Camber Capital Management	0.00	-915.00 k	EXIT

Data from 13F filings, for the last complete 13F reporting period. For most recent data, click the ownership history button. Values as filed, not updated for current price. Long positions only.

Recent insider trades

BCYC insider ownership history Insider history

Date	Owner	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
2 Jan 26	Baker Bros. Advisors	American Depositary Shares	Grant	Acquire A	Yes	No	0	19,000	0.00	10,018,674
2 Jan 26	Baker Bros. Advisors	American Depositary Shares	Grant	Acquire A	Yes	No	0	19,000	0.00	937,483
2 Jan 26	Baker Bros. Advisors	Share Option [object Object]	Grant	Acquire A	Yes	No	7.08	38,000	269.04 k	38,000
2 Jan 26	Baker Bros. Advisors	Share Option [object Object]	Grant	Acquire A	Yes	No	7.08	38,000	269.04 k	38,000
2 Jan 26	Stephen H. Sands	Ordinary Shares	Grant	Acquire A	No	No	0	9,500	0.00	26,893
2 Jan 26	Stephen H. Sands	Stock Option Ordinary Shares	Grant	Acquire A	No	No	7.08	19,000	134.52 k	19,000
2 Jan 26	Alessandro Riva	Ordinary Shares	Grant	Acquire A	No	No	0	7,380	0.00	19,880
2 Jan 26	Alessandro Riva	Stock Option Ordinary Shares	Grant	Acquire A	No	No	7.08	14,761	104.51 k	14,761
2 Jan 26	Dansey Roger D	Ordinary Shares	Grant	Acquire A	No	No	0	3,032	0.00	15,532
2 Jan 26	Dansey Roger D	Stock Option Ordinary Shares	Grant	Acquire A	No	No	7.08	6,065	42.94 k	6,065