Sionna Therapeutics (SION)

Cash burn rate (est.)	Burn method: Change in cash		Burn method: Operating income		Burn method: FCF (opex + capex)
	Last Q	Avg 4Q	Last Q	Avg 4Q	Last Q	Avg 4Q
Cash on hand (at last report)	51.79 mm	51.79 mm	51.79 mm	51.79 mm	51.79 mm	51.79 mm
Cash burn (monthly)	(no burn)	2.66 mm	7.94 mm	5.45 mm	(no burn)	1.34 mm
Cash used (since last report)	n/a	6.41 mm	19.14 mm	13.14 mm	n/a	3.23 mm
Cash remaining	n/a	45.39 mm	32.65 mm	38.65 mm	n/a	48.56 mm
Runway (months of cash)	n/a	17.1	4.1	7.1	n/a	36.2

Beta Read what these cash burn values mean

Financial data from company earnings reports.

Institutional ownership, Q4 2024

SION institutional ownership history Ownership history

13F holders	Current	Prev Q	Change
Total holders	0	0
Opened positions	0	0
Closed positions	0	0
Increased positions	0	0
Reduced positions	0	0

13F shares	Current	Prev Q	Change
Total value	0.00	0.00
Total shares	0.00	0.00
Total puts	0.00	0.00
Total calls	0.00	0.00
Total put/call ratio	–	–	–

Largest owners	Shares	Value	Change

Largest transactions	Shares	Bought/sold	Change

Data from 13F filings, for the last complete 13F reporting period. For most recent data, click the ownership history button. Values as filed, not updated for current price. Long positions only.

Recent insider trades

SION insider ownership history Insider history

Date	Owner	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
5 Dec 25	Jennifer Fitzpatrick	Common Stock	Sell	Dispose S	No	Yes	40.52	10,250	415.33 k	0
5 Dec 25	Jennifer Fitzpatrick	Common Stock	Option exercise	Acquire M	No	Yes	6.11	10,250	62.63 k	10,250
5 Dec 25	Jennifer Fitzpatrick	NQSO Common Stock	Option exercise	Dispose M	No	Yes	6.11	10,250	62.63 k	61,185
26 Nov 25	Thompson Peter A.	Common Stock	Sell	Dispose S	Yes	No	44.49	1,600	71.18 k	3,596,886
26 Nov 25	Orbimed Advisors	Common Stock	Sell	Dispose S	Yes	No	44.49	1,600	71.18 k	3,596,886
25 Nov 25	Thompson Peter A.	Common Stock	Sell	Dispose S	Yes	No	44.6	11,890	530.29 k	3,598,486
25 Nov 25	Orbimed Advisors	Common Stock	Sell	Dispose S	Yes	No	44.6	11,890	530.29 k	3,598,486
24 Nov 25	Thompson Peter A.	Common Stock	Sell	Dispose S	Yes	No	44.54	94,583	4.21 mm	3,610,376
24 Nov 25	Orbimed Advisors	Common Stock	Sell	Dispose S	Yes	No	44.54	94,583	4.21 mm	3,610,376
21 Nov 25	Ra Capital Management	Common Stock	Sell	Dispose S	Yes	No	39.5	7,609	300.56 k	159,033

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.

News

From Benzinga Pro

Crude Oil Gains Over 1%; ISM Manufacturing PMI Falls In November

1 Dec 25

12 Health Care Stocks Moving In Monday's Intraday Session

1 Dec 25

RBC Capital Downgrades Sionna Therapeutics to Underperform, Maintains Price Target to $24

1 Dec 25

RBC Capital analyst Brian Abrahams downgrades Sionna Therapeutics (NASDAQ:SION) from Sector Perform to Underperform and maintains the price target from $24 to $24.

BTIG Initiates Coverage On Sionna Therapeutics with Buy Rating, Announces Price Target of $50

19 Nov 25

12 Health Care Stocks Moving In Tuesday's Pre-Market Session

28 Oct 25

Press releases

From Benzinga Pro

Sionna Therapeutics Announces Presentation of SION-719 and SION-451 Phase 1 Data and Poster of New Preclinical Data on the Impact of NBD1 Stabilizers on F508del-CFTR Half-Life at the 2025 North American Cystic Fibrosis Conference

24 Oct 25

Phase 1 data of first-in-class NBD1 stabilizers, SION-719 and SION-451, demonstrated they were generally well tolerated and exceeded desired pharmacokinetic targets New preclinical data show that NBD1 stabilizers