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| Phase III | ||
| Avastin | Avastin is being evaluated in Avastin is also being evaluated in gastrointestinal stromal tumors, high-risk carcinoid cancer, second-line HER2-negative metastatic BC in combination with several chemotherapy regimens, first-line metastatic BC in combination with endocrine therapy, and | platinum-sensitive relapsed ovarian cancer. |
The combination of Avastin and | ||
| Herceptin | Herceptin is being evaluated | |
| Rituxan | Rituxan is being evaluated in follicular NHL patients who achieve a response following induction with chemotherapy plus Rituxan. This product is being developed in collaboration with Roche and Biogen Idec. | |
| Rituxan | Rituxan is being evaluated for | |
| Tarceva | Tarceva is being evaluated in adjuvant NSCLC. This product is being developed in collaboration with | |
| TNKase is being evaluated in the treatment of dysfunctional hemodialysis and central venous access catheters. | ||
A | ||
Preparing for Phase | III | |
Avastin | We are preparing | |
We are preparing | ||
| Phase II | ||
| Ocrelizumab | Ocrelizumab is being evaluated in relapsing remitting multiple sclerosis. This product is being developed in collaboration with Roche and Biogen Idec(1). | |
| GA101 | GA101 is being evaluated in hematologic malignancies (relapsed and refractory NHL and CLL). This product is being developed in collaboration with Roche and Biogen Idec. | |
| Apo2L/TRAIL | Apo2L/TRAIL is being evaluated in first-line metastatic NSCLC in combination with chemotherapy and Avastin and in indolent relapsed NHL in combination with Rituxan. This product is being developed in collaboration with Amgen. | |
| Apomab | Apomab is being evaluated in first-line metastatic NSCLC in combination with chemotherapy and Avastin, and in indolent relapsed NHL in combination with Rituxan. | |
| Avastin | Avastin is being evaluated in relapsed multiple myeloma, extensive small cell lung cancer, non-squamous NSCLC with previously treated brain metastases, and NSCLC with squamous cell histology. This product is being developed in collaboration with Roche. | |
| Pertuzumab | Pertuzumab is being evaluated in ovarian cancer in combination with chemotherapy. This product is being developed in collaboration with Roche. | |
| Trastuzumab-DM1 | Trastuzumab-DM1 is being evaluated in first, second, and third-line HER2-positive metastatic BC. This product is being developed in collaboration with Roche. | |
| ABT-869 | ABT-869 is being evaluated for the treatment of several types of tumors. This product is being developed in collaboration with Abbott Laboratories. | |
| GDC 0449 (Hedgehog Pathway Inhibitor) | GDC-0449 is being evaluated in first-line metastatic colorectal cancer (CRC) in combination with chemotherapy and Avastin, as a single agent in ovarian cancer maintenance therapy, and as a single agent in advanced basal cell carcinoma. This product is being developed in collaboration with Curis, Inc. and Roche. | |
| Dacetuzumab (Anti-CD40) | Dacetuzumab is being evaluated in combination with Rituxan plus chemotherapy for patients with relapsed or refractory diffuse large B-cell lymphoma. This product is being developed in collaboration with Seattle Genetics, Inc. | |
| Anti-IL13 | Anti-IL13 is being evaluated in patients with uncontrolled asthma. | |
| Preparing for Phase II | ||
| GA101 | We are preparing for a Phase II clinical trial | |
| MetMAb | We are preparing for a Phase II clinical trial of MetMAb and Tarceva as combination therapy in second- and third-line metastatic NSCLC. |
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| Xolair | We are preparing for a Phase II clinical trial in chronic idiopathic urticaria in collaboration with Novartis. | |
| Pertuzumab | We are preparing for a Phase II clinical trial in second-line metastatic NSCLC in combination with Tarceva. This product is being developed in collaboration with Roche. | |
| rhuMAb IFN alpha | We are preparing for a Phase II clinical trial in systemic lupus erythematosus. | |
| Phase I and Preparing for Phase I |
| (1) | Our collaborator Biogen Idec disagrees with certain of our development decisions under our 2003 collaboration agreement. A hearing related to the arbitration began on September 15, 2008 and the hearing was closed on January 8, 2009. We expect to receive a ruling within six months of the conclusion of the hearing, i.e., no later than July 2009. See Part I, Item 3, “Legal Proceedings,” of this Form 10-K for further information. |
Related Party Arrangements
See “Relationship with Roche” and “Related Party Transactions” sections below in Part II, Item 7 of this Form 10-K for information on our collaboration arrangements with Roche F. Hoffmann-La Roche and Novartis.
Distribution and Commercialization
We have a U.S.-based pharmaceutical marketing, sales and distribution organization. Our sales efforts are focused on specialist physicians in private practice or at hospitals and major medical centers in the U.S. In general, our products are sold largely to wholesalers, specialty distributors or directly to hospital pharmacies.pharmacies and specialist physicians in private practice. We utilize common pharmaceutical company marketing techniques, including sales representatives calling on individual physicians and distributors, advertisements, professional symposia, direct mail, and public relations, andas well as other methods.
Through Genentech Access Solutions, we provide reimbursement support, patient assistance programs and customer service programs related to our products. The Genentech Access to Care Foundation offers our products at no chargeprovides free product to eligible uninsured patients and those deemed uninsured due to payer denial in the U.S. that are uninsured. We have established the Genentech Endowment for Cystic Fibrosis to assist cystic fibrosis patients in the U.S. with obtaining Pulmozyme and theThe Genentech Access to Care Foundation for all otheris a non-profit entity funded by Genentech, products. We also provide customer service programs relating to our products. We maintain a comprehensive physician-related product wastage replacement program for Rituxan, Avastin, Herceptin, Activase and TNKase that, subject to specific conditions, provides physicians the right to return these products to us for replacement. We also maintain expired product programs for all our products that, subject to certain specific conditions, provide customers the right to return products to us for replacement or credit at a price based on a 6 month rolling average.Inc. To further support patient access to therapies for variouscertain diseases, in the fourth quarter of 2005, we donated approximately $21.2 milliondonate to various independent third party, public charities that offer financial assistance, such as co-pay assistance, to eligible patients. We also maintain a physician-related product waste replacement program and an expired product program that, subject to certain specific conditions, gives eligible customers the right to renew, modifyreturn expired products to us for replacement or discontinue anycredit at 5% to 8% below their current purchase prices.
In February 2007, we launched the Avastin Patient Assistance Program, a voluntary program that enables eligible patients who receive greater than 10,000 milligrams of Avastin over a 12-month period to receive free Avastin in excess of the patient programs described above.10,000 milligrams during the remainder of the 12-month period. Based on the current wholesale acquisition cost, 10,000 milligrams is valued at $55,000 in gross revenue. Eligible patients include those who are being treated for an FDA-approved indication and who meet the household income criteria for this program. The program is available for eligible patients who enroll regardless of whether they are insured.
As discussed in Note 11,14, “Segment, Significant Customer and Geographic Information,” in the Notes to Consolidated Financial Statements ofin Part II, Item 8 of this Form 10-K, we hadour combined sales to three major customers who eachwholesalers, AmerisourceBergen Corporation, McKesson Corporation, and Cardinal Health, Inc., constituted 86% in 2008 and 2007, and 85% in 2006 of our total net U.S. product sales. Also discussed in Note 14 are net U.S. product sales and net foreign revenue in 2008, 2007, and 2006.
Manufacturing biotherapeutics is difficult and complex,Raw Materials
We manufacture biotherapeutic products and requires facilities specifically designedproduct candidates for commercial and validatedclinical purposes. Our production system includes manufacturing of bulk drug substance, as well as formulation, filling and packaging of the drug product. The bulk drug substance manufacturing process includes cell culture/fermentation operations, during which cells are grown that express proteins which are purified for this purpose. It canuse as therapeutic products. Formulation of the drug product involves filtering and diluting proteins to obtain the appropriate concentrations for human use. In the final processes, we fill vials or syringes with the formulated proteins and package them for distribution.
Our manufacturing network consists of three bulk manufacturing sites in California. We expect FDA licensure of a bulk drug substance manufacturing site in Singapore in 2010. Fill/finish activities take longer than five years to design, construct, validate, and license a new biotechnology manufacturing facility. We currently produce all of our products at our manufacturing facilities locatedplace in South San Francisco, California; Vacaville, California; Porriño, Spain;California. An additional fill/finish facility in Hillsboro, Oregon is planned for licensure in 2010. For further information see also “Properties” in Part I, Item 2 of this Form 10-K. In addition to our owned facilities, we also engage third party contract manufacturers to produce or increasingly, through various contract-manufacturing arrangements.
Raw materials and supplies required for the production of our principal products are, available, in some instances, sourced from one supplier and, in other instances, from multiple suppliers. In those cases wherefor which raw materials are only available through only one supplier, suchthat supplier may be either a sole source (the only recognized supply source available to us) or a single source (the only approved supply source for us among other sources). We have adopted policies tothat attempt, to the extent feasible, to minimize raw material supply risks to the Company,us, including maintenance of greater levels of raw materials inventory and coordination with our collaborators to implement raw materials sourcing strategies.strategies in quantities adequate to meet our needs. Due to the unique nature of the production processes used to manufacture our products, certain raw materials, drug delivery devices and components are the proprietary products of single-source unaffiliated third-party suppliers. In some cases, such proprietary products are specifically cited in our FDA drug application, which limits our ability for substitution. We currently manage the risk associated with such sole-sourced raw materials by active inventory management, relationship management and alternate source development, where feasible. We also monitor the financial condition of certain suppliers, their ability to supply our needs, and the market conditions for these raw materials.
We, as well as our third party service providers, suppliers, and manufacturers are subject to continuing inspection by the FDA or comparable agencies in other jurisdictions. Any delay, interruption or other issues that arise in the manufacture, formulation, filling, packaging, or storage of our products, including as a result of a failure of our facilities or the facilities or operations of third parties to pass any regulatory agency inspection, could significantly impair our ability to sell our products.
We believe that our existing manufacturing network of internal and external facilities and suppliers will allow us to meet our near-term and mid-term manufacturing needs for our current commercial products and our product candidates in clinical trials. Our existing licensed manufacturing facilities operate under multiple licenses from the FDA, regulatory authorities in the European Union, and other regulatory authorities. However, additional manufacturing facilities and outside sources may be required to meet our long-term research, development and commercial production needs.
For additional risks associated with manufacturing and raw materials, see “Difficulties or delays in product manufacturing or in obtaining materials from our suppliers, or difficulties in accurately forecasting manufacturing capacity needs, could harm our business and/or negatively affect our financial performance” under “Risk Factors.”Factors” below in Part I, Item 1A of this Form 10-K.
Proprietary Technology — Technology—Patents and Trade Secrets
We seek patents on inventions originating from our ongoing research and development (or “R&D”)(R&D) activities. We have been issued patents and have patent applications pending that are related to a number of current and potential
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products, including products licensed to others. Patents, issued or applied for, cover inventions ranging from basic recombinant DNA techniques to processes relatingrelated to specific products and to the products themselves. Our issued patents extend for varying periods according to the date of patent application filing or grant and the legal term of patents in the various countries where patent protection is obtained. The actual protection afforded by a patent, which can vary from country to country, depends uponon the type of patent, the scope of its coverage as determined by the patent office or courts in the country, and the availability of legal remedies in the country. We have either been issued patents or have patent applications pending that relate to a number of current and potential products including products licensed to others. We consider that in the aggregate our patent applications, patents and licenses under patents owned by third-partiesthird parties are of material importance to our operations. ImportantFor our five highest selling products, we have identified in the following table the latest-to-expire U.S. patents that are owned or controlled by or exclusively licensed to Genentech having claims directed to product-specific compositions of matter (such as nucleic acids, proteins, and protein-producing host cells). This table does not identify all patents that may be related to these products. For example, in addition to the listed patents, we have patents on platform technologies (that relate to certain general classes of products or methods), as well as patents on methods of using or administering many of our products, that may confer additional patent protection. We also have pending patent applications that may give rise to new patents related to one or more of these products.
Product | Latest-to-Expire Product-Specific U.S. Patent(s) | Year of Expiration |
| Avastin | 6,884,879 7,169,901 | 2017 2019 |
| Rituxan | 5,677,180 5,736,137 7,381,560 | 2014 2015 2016 |
| Herceptin | 6,339,142 6,407,213 7,074,404 | 2019 2019 2019 |
| Lucentis | 6,884,879 7,169,901 | 2017 2019 |
| Xolair | 6,329,509 | 2018 |
The information in the above table is based on our current assessment of patents that we own or control or have exclusively licensed. The information is subject to revision, for example, in the event of changes in the law or legal rulings affecting our patents or if we become aware of new information. Significant legal issues remain to be resolvedunresolved as to the extent and scope of available patent protection for biotechnology products and processes in the U.S. and other important markets outside of the U.S. We expect that litigation will likely be necessary to determine the term, validity, andenforceability, and/or scope of certain of our patents and other proprietary rights. An adverse decision or ruling with respect to one or more of our patents could result in the loss of patent protection for a product and, in turn, the introduction of competitor products or follow-on biologics to the market earlier than anticipated, and could force us to either obtain third-party licenses at a material cost or cease using a technology or commercializing a product. We are currently involved in a number of legal proceedings relating to the scope of protection and validity ofinvolving our patents and those of others. These proceedings may result in a significant commitment of our resources in the future and, depending on their outcome, may adversely affect the term, validity, andenforceability, and/or scope of certain of our patent or other proprietary rights. We cannot assure yourights (such as the Cabilly patent discussed in Item 3, “Legal Proceedings”), and may cause us to incur a material loss of royalties, other revenue, and/or market exclusivity for one or more of our products. The patents that the patents we obtain or the unpatented proprietary technology that we hold willmay not afford us significant commercial protection.
We have obtained licenses from various parties that we deem to be necessary or desirable for the manufacture, use, or sale of our products. These licenses (both exclusive and non-exclusive) generally require us to pay royalties to the parties on product sales. In conjunction with these licenses, disputes sometimes arise regarding whether royalties are owed on certain product sales or the amount of royalties that are owed. The resolution of such disputes may cause us to incur significant additional royalty expenses or other expenses.
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Our trademarks, trademarks—Activase, Avastin, Cathflo, Genentech, Herceptin, Lucentis, Nutropin, Nutropin AQ, Nutropin AQ Pen, Omnitarg, Pulmozyme, Raptiva, Rituxan (licensed from Biogen Idec), TNKase, Xolair (licensed from Novartis), and Tarceva (licensed from OSI), OSI Pharmaceuticals)—in the aggregate are considered to be of material importance. All of our trademarks are covered by registrations or pending applications for registration in the U.S. Patent and Trademark Office (Patent Office) and in other countries. Trademark protection continues in some countries for as long as the mark is used and, in other countries, for as long as it is registered. Registrations generally are for fixed, but renewable, terms.
Our royalty incomerevenue for patent licenses, know-how, and other related rights amounted to $935.1$2,539 million in 2005, $641.12008, $1,984 million in 2004,2007, and $500.9$1,354 million in 2003.2006. Royalty expenses were $462.4$753 million in 2005, $355.02008, $712 million in 2004,2007, and $244.6$568 million in 2003.2006.
Competition
We face competition from pharmaceutical companies pharmaceutical divisions of chemical companies, and biotechnology companies.
The introduction of new competitive products, orincluding follow-on biologics, new safety or newefficacy information about existing products, pricing decisions by us or our competitors, the rate of market penetration by competitors’ products, and/or development and use of alternate therapies may result in lost market share for us, reduced utilization of our products, lower prices, and/or lower prices,reduced product sales, even for products protected by patents.
For risks associated with competition, see “We face competition” under “Risk Factors.”Factors” below in Part I, Item 1A of this Form 10-K.
Government Regulation
Regulation by governmental authorities in the U.S. and other countries is a significant factor in the manufacture and marketing of our products and in ongoing research and product development activities. All of our products require regulatory approval by governmental agencies prior to commercialization. Our products are subject to rigorous preclinical and clinical testing and other premarket approval requirements by the FDA and regulatory authorities in other countries. Various statutes and regulations also govern or influence the manufacturing, safety, labeling, storage, record keeping, and marketing of such products. The lengthy process of seeking these approvals, and the subsequent compliance with applicable statutes and regulations, require the expenditure of substantial resources.
The activities that are required before a pharmaceutical product may be marketed in the U.S. begin with preclinical testing. Preclinical tests include laboratory evaluation of product chemistry and required animal studies to assess the
potential safety and efficacy of the product and its formulations. The results of these studies must be submitted to the FDA as part of an Investigational New Drug Application, which must be reviewed by the FDA before proposed clinical testing in humans can begin. Typically, clinical testing involves a three-phase process. In Phase I, clinical trials are conducted with a small number of subjects to determine the early safety profile and the pattern of drug distribution and metabolism. In Phase II, clinical trials are conducted with groups of patients afflicted with a specifiedspecific disease in order to provide enough data to evaluate the preliminary efficacy, optimal dosages, and expanded evidence of safety. In Phase III, large scale, multicenterlarge-scale, multi-center clinical trials are conducted with patients afflicted with a target disease in order to provide enough data to statistically evaluate the efficacy and safety of the product, as required by the FDA. The results of the preclinical and clinical testing of a chemical pharmaceutical product are then submitted to the FDA in the form of a New Drug Application (or “NDA”)(NDA), or for a biological pharmaceutical product in the form of a BLA,Biologic License Application (BLA), for approval to commence commercial sales. In responding to an NDA or a BLA, the FDA may grant marketing approval, grant conditional approval (such as an accelerated approval), request additional information, or deny the application if itthe FDA determines that the application does not provide an adequate basis for approval. Most R&D projects fail to produce data sufficiently compelling to enable progression through all of the stages of development and to obtain FDA approval for commercial sale. See also “The successful development of biotherapeuticspharmaceutical products is highly uncertain and requires significant expenditures”expenditures and time” under “Risk Factors.”Factors” below in Part I, Item 1A of this Form 10-K.
Among the conditions for an NDA or a BLA approval is the requirement that the prospective manufacturer’s quality control and manufacturing procedures conform on an ongoing basis with current Good Manufacturing Practices (or “GMP”)(cGMP). Before approval of a BLA, the FDA will usually perform a preapproval inspection of the facility to determine its compliance with GMPcGMP and other rules and regulations. Manufacturers must continue to expend time, money and
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effort in the area of production and quality control to ensure full compliance with GMP.cGMP. After the establishmenta facility is licensed for the manufacture of any product, manufacturers are subject to periodic inspections by the FDA.
We are also subject to various laws and regulations relatingrelated to safe working conditions, clinical, laboratory and manufacturing practices, the experimental use of animals and the use and disposal of hazardous or potentially hazardous substances, including radioactive compounds and infectious disease agents, used in connection with our research.
In addition, in the U.S. and elsewhere, sales of therapeutic and other pharmaceutical products are dependent in part on the availability of reimbursement to the physician or consumer from third-party payers, such as the government or private insurance plans. Government and private third-party payers are increasingly challenging the prices charged for medical products and services, through class actionclass-action litigation and otherwise. For example, the Medicare Prescription Drug ImprovementNew regulations related to hospital and Modernization Act, enacted in December 2003 (or “Medicare Act”), decreased the Medicare reimbursement rate for many drugs, including our oncology products, possibly offset to some extent by increased physician payment rates for drug administration services relatedcontinue to certainbe implemented annually. To date, we have not seen any material effects of the new rules on our oncology products. It is unclear how these changes in reimbursement rates for products administered by oncologists in the office setting will affect physician prescribing practices and ultimately the sales of our products.product sales. See also “Decreases in third partythird-party reimbursement rates may affect our product sales, results of operations and financial condition” under “Risk Factors.”Factors” below in Part I, Item 1A of this Form 10-K.
We are also subject to various federal and state laws pertaining to health carehealthcare fraud and abuse, including anti-kickback laws and false claims laws. For risks associated with health carehealthcare fraud and abuse, see "If“If there is an adverse outcome in our pending litigation or other legal actions, our business may be harmed” under "Risk Factors."“Risk Factors” below in Part I, Item 1A of this Form 10-K.
Research and Development
A significant portion of our operating expenses is related to R&D. Generally, R&D expenses consist of the costs of our own independent R&D costsefforts and the costs associated with collaborative R&D and in-licensing arrangements. R&D costs, including up-front fees and milestone payments paid to collaborators, are expensed as incurred. Costs associated with in-licensing arrangements are expensed as incurred if the underlying technology and/or intellectual property rights acquired are determined to not have an alternative future use. R&D expenses, excluding any acquisition-related in-process research and development charges, were $1,261.8$2,800 million in 2005, $947.52008, $2,446 million in 2004,2007, and $722.0$1,773 million in 2003. 2006. We also receive reimbursements from certain collaborators on some of our R&D expenditures, depending on the mix of spending between us and our collaborators. These R&D expense reimbursements are primarily included in contract revenue, and were $227 million in 2008, $196 million in 2007, and $185 million in 2006.
We intend to maintain our strong commitment to R&D. Biotechnology products generally take 10 to 15 years to research, develop, and bring to market in the U.S. As discussed above, clinical development typically involves three phases of study: Phase I, II, and III. The most significant costs associated with clinical development are the Phase III trials, as they tend to be the longest and largest studies conducted during the drug development process. Product completion datestimelines and completion costs vary significantly by product and are difficult to predict.
Human Resources
As of December 31, 2005,2008, we had over 9,50011,186 employees.
Environment
We have made, and will continue to make, expenditures for environmental compliance and protection. Expenditures for compliance with environmental laws and regulations have not had, and are not expected to have, a material effect on our capital expenditures, results of operations, or competitive position.
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Available Information
The following information can be found on our website at http://www.gene.com or can be obtained free of charge by contacting our Investor Relations Department at (650) 225-1599225-4150 or by sending an e-mail message to investor.relations@gene.com:
| Ÿ |
| Ÿ |
| Ÿ |
Item 1A. |
This Form 10-K contains forward-looking information based on our current expectations. Because our actual results may differ materially from any forward-looking statements that we make or that are made by Genentech,on our behalf, this section includes a discussion of important factors that could affect our actual future results, including, but not limited to, our product sales, royalties, contract revenues,revenue, expenses, net income, and earnings per share.
The successful development of biotherapeuticspharmaceutical products is highly uncertain and requires significant expenditures and time.
Successful development of biotherapeuticspharmaceutical products is highly uncertain. Products that appear promising in research or early phases of development may be delayed or fail to reach later stages of development or the market for several reasons, including:
| Preclinical tests may show the product to be toxic or lack efficacy in animal models. |
| Clinical trial results may show the product to be less effective than desired or to have harmful or problematic side effects. |
| Failure to receive the necessary U.S. and international regulatory approvals or a delay in receiving such approvals. Among other things, such delays may be caused by slow enrollment in clinical |
| Ÿ | Difficulties in formulating the product, scaling the manufacturing process, or |
| Manufacturing costs, pricing, |
| The proprietary rights of others and their competing products and technologies |
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| Ÿ | The contractual or intellectual property rights of our collaborators or others may prevent the product from being developed or commercialized. |
Success in preclinical and early clinical trials does not ensure that large-scale clinical trials will be successful. Clinical results are frequently susceptible to varying interpretations that may delay, limit, or prevent regulatory approvals. The length of time necessary to complete clinical trials and to submit an application for marketing approval for a final decision by a regulatory authority varies significantly and may be difficult to predict. If our large-scale clinical trials for a product are not successful, we will not recover our substantial investments in thethat product.
Factors affecting our research and development (or “R&D”)R&D productivity and the amount of our R&D expenses include, but are not limited to:
| The number |
| The number of products entering into development from late-stage research. For example, there is no guarantee that internal research efforts will succeed in generating a sufficient |
| Decisions by |
| Ÿ |
| Participation in a number of collaborative |
| Charges incurred in connection with expanding our product manufacturing capabilities, as described below in “Difficulties or delays in product manufacturing or in obtaining materials from our suppliers, or difficulties in accurately forecasting manufacturing capacity needs, could harm our business and/or negatively affect our financial |
| Future levels of revenue. |
| Ÿ | Our ability to supply product for use in clinical trials. |
We face competition.
We face competition from pharmaceutical companies and biotechnology companies.
The introduction of new competitive products or follow-on biologics, new safety or efficacy information about or new indications for existing products, pricing decisions by us or our competitors, the rate of market penetration by competitors’ products, and/or development and use of alternate therapies may result in lost market share for us; reduced utilization of our products; lower prices; and/or reduced product sales, even for products protected by patents.
Avastin: Avastin competes in metastatic CRC with Erbitux® (ImClone Systems Inc. (a wholly-owned subsidiary of Eli Lilly and Company)/Bristol-Myers Squibb/Merck KGaA), which is an epidermal growth factor receptor (EGFR) inhibitor approved for the treatment of irinotecan refractory or intolerant metastatic CRC patients; and with Vectibix™ (Amgen Inc.), which is indicated for the treatment of patients with EGFR-expressing metastatic CRC who have disease progression on or following fluoropyrimidine, oxaliplatin, and irinotecan-containing regimens.
Avastin could also face competition from Erbitux® in metastatic NSCLC. At the 2008 annual meeting of the American Society of Clinical Oncology (ASCO), ImClone and Bristol-Myers Squibb presented data from a Phase III study of Erbitux® in combination with vinorelbine plus cisplatin showing that the study met its primary endpoint of increasing overall survival compared with chemotherapy alone in patients with advanced NSCLC. ImClone and Bristol-Myers Squibb submitted, then withdrew, and plan to eventually resubmit, an sBLA for U.S. approval with the FDA for advanced NSCLC. Merck KGaA has filed a European application for Erbitux® in this indication. Avastin also faces competition in advanced or metastatic NSCLC from the chemotherapy Alimta® (Eli Lilly), which received approval in the third quarter of 2008 for use in first-line NSCLC in combination with cisplatin. The approval for Alimta® in first line NSCLC is limited to use in patients with non-squamous histology. In NSCLC, both Erbitux® and Alimta® are included in the National Comprehensive Cancer Network (NCCN) guidelines and compendia as first-line options. The Erbitux® listing in the first-line setting is limited to combinations with cisplatin and vinorelbine. Alimta® is listed as an option for non-squamous patients in the first-line setting and as maintenance therapy for patients previously having a response.
Other potential Avastin competitors include Nexavar® (sorafenib, Bayer Corporation/Onyx Pharmaceuticals, Inc.), Sutent® (sunitinib malate, Pfizer Inc.), and Torisel® (Wyeth) for the treatment of patients with advanced renal cell carcinoma (an unapproved use of Avastin).
Avastin could face competition from products in development that currently do not have regulatory approval. Sanofi-Aventis is developing a vascular endothelial growth factor (VEGF) inhibitor, VEGF-Trap, in multiple indications, including metastatic CRC and metastatic NSCLC. Avastin could also face competition from the VEGF receptor-2 inhibitor (IMC-1121b) under development by ImClone in several indications, including BC. There are also ongoing head-to-head clinical trials comparing both Sutent® and AZD2171 (AstraZeneca) to Avastin. Likewise, Amgen is conducting head-to-head clinical trials comparing AMG 706 to Avastin in NSCLC and metastatic BC, and Pfizer is conducting a head-to-head trial comparing Sutent® to Avastin in BC. Antisoma’s vascular disrupting agent, ASA404, has an ongoing Phase III trial in first-line NSCLC (ATTRACT-1) and a planned Phase III trial in second-line NSCLC (ATTRACT-2). Overall, there are more than 65 molecules in clinical development that target VEGF inhibition that, if successful in clinical trials, may compete with Avastin.
Rituxan: Current competitors for Rituxan in hematology-oncology include Bexxar® (GlaxoSmithKline [GSK]) and Zevalin® (Cell Therapeutics), both of which are radioimmunotherapies indicated for the treatment of patients with relapsed or refractory low-grade, follicular, or transformed B-cell NHL. Cell Therapeutics recently filed an sBLA based on data from the Zevalin FIT trial, showing a benefit as consolidation therapy in frontline follicular NHL. Bexxar has an ongoing study nearing completion that may also expand its label to earlier settings in indolent NHL. Other potential competitors include Campath® (Bayer Corporation/Genzyme Corporation) in previously untreated and relapsed CLL (an unapproved use of Rituxan); Velcade® (Millennium Pharmaceuticals, Inc.), which is indicated for multiple myeloma and more recently mantle cell lymphoma (both unapproved uses of Rituxan); Revlimid® (Celgene Corporation), which is indicated for multiple myeloma and myelodysplastic syndromes (both unapproved uses of Rituxan); and Treanda® (Cephalon, Inc.), which is approved for CLL and was recently approved for the treatment of indolent NHL patients who have progressed while on or shortly after a Rituxan-containing regimen.
Current competitors for Rituxan in RA include Enbrel® (Amgen/Wyeth), Humira® (Abbott), Remicade® (Johnson & Johnson), Orencia® (Bristol-Myers Squibb), and Kineret® (Amgen). These products are approved for use in an RA patient population that is broader than the population in which Rituxan is approved for use. In addition, molecules in development that, if approved by the FDA, may compete with Rituxan in RA include: Actemra™, an anti-interleukin-6 receptor being developed by Chugai Pharmaceutical Co. Ltd. and Roche; Cimzia™ (certolizumab pegol), an anti-TNF antibody being developed by UCB S.A.; and CNTO 148 (golimumab), an anti-TNF antibody being developed by Centocor and Schering-Plough Corporation.
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Rituxan may face future competition in both hematology-oncology and RA from Arzerra™ (ofatumumab), an anti-CD20 antibody being co-developed by Genmab A/S and GSK. Genmab and GSK recently presented positive results from their pivotal trial for CLL at the American Society of Hematology meeting. They announced on January 30, 2009 that they filed for approval of Arzerra™ for monotherapy use in refractory CLL. Additional ongoing studies include a monotherapy trial for refractory indolent NHL. In addition, we are aware of other anti-CD20 molecules in development that, if successful in clinical trials, may compete with Rituxan. Finally, positive results were announced from a pivotal trial for BiovaxID™ (BioVest International, Inc.) for indolent NHL patients post front-line induction. BioVest has announced plans to file for approval of BiovaxID™ in indolent NHL in the U.S.
Herceptin: Herceptin faces competition in the relapsed metastatic setting from Tykerb® (lapatinib ditosylate) which is manufactured by GSK. Tykerb® is approved in combination with capecitabine for the treatment of patients with advanced or metastatic BC whose tumors overexpress HER2 and who have received prior therapy, including an anthracycline, a taxane, and Herceptin. Tykerb® is currently being studied in adjuvant and multiple lines of metastatic HER2-positive BC.
Lucentis: We are aware that retinal specialists are currently using Avastin to treat the wet form of AMD, an unapproved use for Avastin, which results in significantly less revenue to us per treatment compared to Lucentis. As of January 1, 2008, we no longer directly supply Avastin to compounding pharmacies. Ocular use of Avastin continues, as physicians can purchase Avastin from authorized distributors and have it shipped to the destination of the physicians’ choice. Additionally, an independent head-to-head trial of Avastin and Lucentis in wet AMD is being partially funded by the National Eye Institute, which announced that enrollment had commenced in February 2008. Lucentis also competes with Macugen® (Pfizer/OSI Pharmaceuticals), and with Visudyne® (Novartis) alone, in combination with Lucentis, in combination with Avastin, or in combination with off-label steroids in wet AMD. In addition, VEGF-Trap-Eye, a vascular endothelial growth factor blocker being developed by Bayer and Regeneron Pharmaceuticals, Inc., is in Phase III clinical trials for the treatment of wet AMD.
Xolair: Xolair faces competition from other asthma therapies, including inhaled corticosteroids, long-acting beta agonists, combination products such as fixed-dose inhaled corticosteroids/long-acting beta agonists and leukotriene inhibitors, as well as oral corticosteroids and immunotherapy.
Tarceva: Tarceva competes with the chemotherapy agents Taxotere® (Sanofi-Aventis) and Alimta® (Eli Lilly) both of which are indicated for the treatment of relapsed NSCLC. Tarceva may face future competition in relapsed NSCLC from Zactima™ (AstraZeneca), Erbitux® (Bristol-Myers Squibb/ImClone), ASA404 (Novartis/Antisoma), and from a potential re-filing of Iressa® (AstraZeneca) in the U.S. Alimta® received approval in the third quarter of 2008 for first-line treatment of locally advanced and metastatic NSCLC, for patients with non-squamous histology. Eli Lilly has filed with the FDA for U.S. approval of Alimta® in first-line maintenance NSCLC. ImClone and Bristol-Myers Squibb have filed with the FDA for U.S. approval of Erbitux® in first-line NSCLC. Both Alimta® and Erbitux® are compendia listed and included in the NCCN guidelines for first-line metastatic NSCLC in accordance with their trials. In front-line pancreatic cancer, Tarceva primarily competes with Gemzar® (Eli Lilly) monotherapy and Gemzar® in combination with other chemotherapeutic agents. Tarceva could face competition in the future from products in development for the treatment of pancreatic cancer. We could face competition from generic versions of Tarceva. In February 2009, OSI Pharmaceuticals, with whom we collaborate on Tarceva, announced receipt of a notice letter advising that Teva Pharmaceuticals USA, Inc. submitted an Abbreviated New Drug Application (ANDA) to the FDA requesting permission to manufacture and market a generic version of Tarceva. OSI Pharmaceuticals announced that it expects to file a patent infringement lawsuit against Teva seeking to restrict approval of the ANDA.
Nutropin: Nutropin faces competition in the growth hormone market from multiple competitors, including Humatrope® (Eli Lilly), Genotropin® (Pfizer), Norditropin® (Novo Nordisk), Saizen® (Merck Serono), and Tev-Tropin® (Teva Pharmaceutical Industries Ltd.). In addition, Accretropin® (Cangene Corporation), a biologic growth hormone, has been approved and is also pending launch. Nutropin also faces competition from follow-on biologics, including Omnitrope® (Sandoz Inc.) and Valtropin® (LG Life Sciences Ltd.), the latter of which has been approved and is pending launch.
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As a result of this competition, we have experienced and may continue to experience a loss of patient share and increased competition for managed care product placement. Obtaining placement on the preferred product lists of managed care companies may require that we further discount the price of Nutropin. In addition to managed care placement, patient and healthcare provider services provided by growth hormone manufacturers are increasingly important to creating brand preference.
Thrombolytics: Our thrombolytic products face competition in the acute myocardial infarction market, with sales of TNKase and Activase affected by the adoption by physicians of mechanical reperfusion strategies. We expect that the use of mechanical reperfusion, in lieu of thrombolytic therapy for the treatment of acute myocardial infarction, will continue to grow. TNKase for acute myocardial infarction also faces competition from Retavase® (EKR Therapeutics, Inc.).
Pulmozyme: Pulmozyme currently faces competition from the use of hypertonic saline, an inexpensive approach to clearing sputum from the lungs of cystic fibrosis patients. Approximately 30 percent of cystic fibrosis patients receive hypertonic saline, and we estimate that in a small percentage of patients (less than 5 percent), this use will affect how a physician may prescribe or a patient may use Pulmozyme. Infants and toddlers are most likely to be prescribed hypertonic saline rather than Pulmozyme.
Raptiva: Raptiva competes with established therapies for moderate-to-severe psoriasis, including oral systemics such as methotrexate and cyclosporin as well as ultraviolet light therapies. In addition, Raptiva competes with biologic agents Amevive® (Astellas Pharma AG), Enbrel®, and Remicade®. Raptiva also competes with the biologic agent Humira®, which was approved by the FDA for use in moderate-to-severe psoriasis on January 18, 2008. Raptiva may face future competition from the biologic Ustekinumab/CNTO-1275 (Centocor), for which a filing was made with the FDA for approval in the treatment of psoriasis on December 4, 2007. Additionally, we expect Raptiva to lose market share to competitors due to cases of progressive multifocal leukoencephalopathy (PML) in Raptiva patients as discussed in “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in Part II, Item 7 of this Form 10-K.
In addition to the commercial and late-stage development products listed above, numerous products are in earlier stages of development at other biotechnology and pharmaceutical companies that, if successful in clinical trials, may compete with our products.
Changes in the third-party reimbursement environment may affect our product sales, results of operations, and financial condition.
Sales of our products will depend significantly on the extent to which reimbursement for the cost of our products and related treatments will be available to physicians and patients from various levels of U.S. and international government health administration authorities, private health insurers, and other organizations. Third-party payers and government health administration authorities increasingly attempt to limit and/or regulate the reimbursement of medical products and services, including branded prescription drugs. Changes in government legislation or regulation, such as the Medicare Prescription Drug Improvement and Modernization Act of 2003; the Deficit Reduction Act of 2005; the Medicare, Medicaid, and State Children’s Health Insurance Program Extension Act of 2007; and the Medicare Improvements for Patients and Providers Act of 2008; changes in formulary or compendia listings; or changes in private third-party payers’ policies toward reimbursement for our products may reduce reimbursement of our products’ costs to physicians, pharmacies, and distributors. Decreases in third-party reimbursement for our products could reduce usage of the products, sales to collaborators, and royalties, and may have a material adverse effect on our product sales, results of operations, and financial condition. The pricing and reimbursement environment for our products may change in the future and become more challenging due to, among other reasons, policies advanced by the new presidential administration, new healthcare legislation passed by Congress or fiscal challenges faced by all levels of government health administration authorities.
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We may be unable to obtain or maintain regulatory approvals for our productsproducts.
We are subject to stringent regulationregulations with respect to product safety and efficacy by various international, federal, state, and local authorities. Of particular significance are the FDA’s requirements covering R&D, testing, manufacturing, quality control, labeling, and promotion of drugs for human use. A biotherapeutic cannot be marketed in the United States (or “U.S.”) until it has been approved by the FDA, and then can only be marketed for the indications approved by the FDA. As a result of these requirements, the length of time, the level of expenditures, and the laboratory and clinical information required for approval of a New Drug ApplicationBLA or a BLA,NDA are substantial and can require a number of years. In addition, even if our products receive regulatory approval, they remain subject to ongoing FDA regulation,regulations, including, for example, obligations to conduct additional clinical trials or other testing, changes to the product label, new or revised regulatory requirements for manufacturing practices, written advisements to physicians, and/or a product recall.recall or withdrawal.
We may not obtain necessary regulatory approvals on a timely basis, if at all, for any of the products we are developing or manufacturing, or we may not maintain necessary regulatory approvals for our existing products, and all of the following could have a material adverse effect on our business:
| Significant delays in obtaining or failing to obtain |
| Loss of, or changes to, previously obtained approvals or accelerated approvals, including those resulting from post-approval safety or efficacy issues. For example, with respect to the FDA’s accelerated approval of Avastin in combination with paclitaxel chemotherapy for the treatment of patients who have not received prior chemotherapy for metastatic HER2-negative BC, the FDA may withdraw or modify such approval, or request additional post-marketing studies. Additionally, we may be unable to maintain regulatory approval for Raptiva, or we may be subject to other regulatory requirements or actions that significantly restrict the use of Raptiva, due to cases of PML in Raptiva patients. On February 19, 2009, the European Medicines Agency announced that it recommended the suspension of the marketing authorization for Raptiva from our collaborator, Merck Serono, and the FDA issued a public health advisory regarding Raptiva, as discussed in “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in Part II, Item 7 of this Form 10-K. |
| Failure to comply with existing or future regulatory requirements. |
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| Ÿ | Changes to manufacturing processes, manufacturing process standards, or |
In addition, the current regulatory framework could change, or additional regulations could arise at any stage during our product development or marketing whichthat may affect our ability to obtain or maintain approval of our products or require us to make significant expenditures to obtain or maintain such approvals.
Difficulties or delays in product manufacturing or difficulties in obtaining materials from our suppliersaccurately forecasting manufacturing capacity needs, could harm our business and/or negatively affect our financial performanceperformance.
Manufacturing biotherapeuticspharmaceutical products is difficult and complex, and requires facilities specifically designed and validated for thisthat purpose. It can take longermore than five years to design, construct, validate, and license a new biotechnology manufacturing facility. We currently produce all of our products at our manufacturing facilities located in South San Francisco, California; Vacaville, California; Porriño, Spain; or increasinglyand Oceanside, California, and through various contract-manufacturing arrangements. Problems with any of our or our contractors’ manufacturing processes could result in failure to produce adequate product supplies or product defects which could require us to delay shipment of products, recall products previously shipped or be unable to supply products at all. In addition, we may need to record period charges associated with manufacturing or inventory failures or other production-related costs that are not absorbed into inventory or incur costs to secure additional sources of capacity. Furthermore, there are inherent uncertainties associated with forecasting future demand, especially for newly introduced products of ours or of those for whom we produce products, and as a consequence we may have inadequate capacity to meet our own actual demands and/or the actual demands of those for whom we produce product.
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| Ÿ | Equipment obsolescence, malfunctions, or failures. |
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In addition, there are inherent uncertainties associated with forecasting future demand or actual demand for our products or products that we produce for others, and as a consequence we may have inadequate capacity or inventory to meet actual demand. Alternatively, as a result of these inherent uncertainties, we may have excess capacity or inventory, which could lead to an idling of a portion of our manufacturing processesfacilities, during which time we would incur unabsorbed or idle plant charges, costs associated with the termination of existing contract manufacturing relationships, costs associated with a reduction in workforce, costs associated with unsalable inventory, or other excess capacity charges, resulting in an increase in our cost of sales (COS). For example, in 2008, we recognized charges of approximately $90 million related to unexpected failed lots, delays in manufacturing start-up campaigns, and those of our contractors are highly complex and are subject to a lengthy FDA approval process, alternative qualified production capacity may not be available on a timely basis or at all. excess capacity.
Difficulties or delays in our or our contractors’ manufacturing and supply of existing or new products could increase our costs,costs; cause us to lose revenue or market share,share; damage our reputationreputation; and could result in a material adverse effect on our product sales, financial condition, and results of operations.
Difficulties or delays in our or our contractors’ supply of existing or new products could increase our costs; cause us to lose revenue or market share; damage our reputation; and result in a material adverse effect on our product sales, financial condition, and results of operations.
Protecting our proprietary rights is difficult and costlycostly.
The patent positions of pharmaceutical and biotechnology companies can be highly uncertain and involve complex legal and factual questions. Accordingly, we cannot predict with certainty the breadth of claims that will be allowed
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in these companies’patents, nor can we predict with certainty the outcome of disputes about the infringement, validity, or enforceability of patents. Patent disputes are frequent and canmay ultimately preclude the commercialization of products. We have in the past been, are currently, and may in the future be involved in material litigation and other legal proceedings relatingrelated to our proprietary rights, such as the Cabilly reexaminations discussedpatent litigation and re-examination (discussed in Note 7,9, “Leases, Commitments, and Contingencies,” in the Notes to Consolidated Financial Statements ofin Part II, Item 8 of this Form 10-K.10-K), the proprietary rights of third parties, and disputes in connection with licenses granted to or obtained from third parties. Such litigation and other legal proceedings are costly in their own right and could subject us to significant liabilities to third-parties. Anincluding the payment of significant royalty expenses, the loss of significant royalty income, or other expenses or losses. Furthermore, an adverse decision or ruling could force us to either obtain third-party licenses at a material cost, or cease using the technology in dispute, terminate the R&D or commercializing thecommercialization of a product, in dispute. An adverse decision with respect to one or more of our patents or other intellectual property rights could cause us to incur a material loss of sales and/or royalties and other revenue from licensing arrangements that we have with third-parties, and couldthird parties, and/or significantly interfere with our ability to negotiate future licensing arrangements.
The presence of patents or other proprietary rights belonging to other parties may subject us to infringement claims and may lead to our termination of the R&D of a particular product, a loss of our entire investment in thea product and subject us to infringement claims.or technology.
If there is an adverse outcome in our pending litigation or other legal actions, our business may be harmedharmed.
Litigation and other legal actions to which we are currently or have been subjected relatessubject to relate to, among other things, our patent and other intellectual property rights, licensing arrangements and other contracts with other persons,third parties, and product liability and financing activities.liability. We cannot predict with certainty the eventual outcome of pending litigation,proceedings, which may include an injunction against the development, manufacture, or sale of a product or potential product orproduct; a judgment with a significant monetary award, including the possibility of punitive damages,damages; or a judgment that certain of our patent or other intellectual property rights are
invalid or unenforceable. Furthermore, we may have to incur substantial expense in defending these lawsuitsproceedings, and these lawsuitssuch matters could divert management’s attention from ongoing business concerns.
Our activities relatingrelated to the sale and marketing of our products are subject to regulation under the U.S. Federal Food, Drug, and Cosmetic Act and other federal and state statutes. Violations of these laws may be punishable by criminal and/or civil sanctions, including fines and civil monetary penalties, as well as the possibility of exclusion from federal health carehealthcare programs (including Medicare and Medicaid). In 1999, we agreed to pay $50 million to settle a federal investigation relatingrelated to our past clinical, sales, and marketing activities associated with human growth hormone. We are currently being investigated by the Department of Justice with respect to our promotional practices of Rituxan, and may in the future be investigated for our promotional practices relatingrelated to any of our products. If the government were to bring charges against or convict us, if we were convicted of violating these laws,federal or state statutes, or if we were subject to third partythird-party litigation relatingrelated to the same promotional practices, there could be a material adverse effect on our business, including our financial condition and results of operations.
We are subject to various U.S. federal and state laws pertaining to healthcare fraud and abuse, including anti-kickback and false claims laws. Anti-kickback laws make it illegal for a prescription drug manufacturer to solicit, offer, receive, or pay any remuneration in exchange for, or to induce, the referral of business, including the purchase or prescription of a particular drug. Due in part to the breadth of the statutory provisions and the absence of guidance in the form of regulations or court decisions addressing some of our practices, it is possible that our practices might be challenged under anti-kickback or similar laws. False claims laws prohibit anyone from knowingly and willingly presenting, or causing to be presented for payment to third-party payers (including Medicare and Medicaid), claims for reimbursed drugs or services that are false or fraudulent, claims for items or services not provided as claimed, or claims for medically unnecessary items or services. Violations of fraud and abuse laws may be punishable by criminal and/or civil sanctions, including fines and civil monetary penalties, as well as the possibility of exclusion from federal health carehealthcare programs (including Medicare and Medicaid). If a courtwe were to find usfound liable for violating these laws, or if the government were to allege againstthat we have violated, or convict usif we are convicted of violating these laws, there could be a material adverse effect on our business, including on our stock price.
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The review and response to the Roche Proposal, the Roche Tender Offer or any other tender offer or other proposal by Roche and related matters requires the expenditure of significant time and resources by us and may be a significant distraction for our management and employees. The Roche Proposal or the Roche Tender Offer may create uncertainty for our management, employees, current and potential collaborators, and other third parties. On August 18, 2008, the Special Committee adopted two retention plans and two severance plans that together cover substantially all employees of the company, including our named executive officers. The two retention plans were implemented in lieu of our 2008 annual stock option grant and the two severance plans were adopted in addition to existing severance plans. Nevertheless, this uncertainty could adversely affect our ability to retain key employees and to hire new talent; cause collaborators to terminate, or not to renew or enter into arrangements with us; and negatively impact our abilitybusiness during the pendency of the Roche Tender Offer or any other tender offer or other proposal by Roche or anytime thereafter. Additionally, we, members of our Board of Directors, and Roche entities have been named in several purported stockholder class-action complaints related to manufacture those products for an indefinite periodthe Roche Proposal and may be named in lawsuits related to the Roche Tender Offer, which are more fully described in Note 9, “Leases, Commitments, and Contingencies,” in the Notes to Consolidated Financial Statements in Part II, Item 8 of time (or at least until an alternative process is approved), negatively affectthis Form 10-K. These lawsuits or any future lawsuits may become burdensome and result in significant costs of defense, indemnification, and liability. These consequences, alone or in combination, may harm our reputationbusiness and could result inhave a material adverse effect on our results of operations. See also “RHI, our controlling stockholder, may seek to influence our business in a manner that is adverse to us or adverse to other stockholders who may be unable to prevent actions by RHI” and “Our Affiliation Agreement with RHI could adversely affect our cash position.”
RHI, our controlling stockholder, may seek to influence our business in a manner that is adverse to us or adverse to other stockholders who may be unable to prevent actions by RHI.
As our majority stockholder, RHI controls the outcome of most actions requiring the approval of our stockholders. Our bylaws provide, among other things, that the composition of our Board of Directors shall consist of at least three directors designated by RHI, three independent directors nominated by the Nominations Committee, and one Genentech executive officer nominated by the Nominations Committee. Our bylaws also provide that RHI will have the right to obtain proportional representation on our Board of Directors until such time that RHI owns less than five percent of our stock. In connection with the Roche Tender Offer, RHI stated that whether or not the tender offer is consummated, RHI may exercise its rights to obtain proportional representation on our Board of Directors and take a more active role in overseeing the management and policies of Genentech. Currently, three of our directors—Mr. William Burns, Dr. Erich Hunziker, and Dr. Jonathan K. C. Knowles—also serve as officers and employees of
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Roche. As long as RHI owns more than 50 percent of our Common Stock, RHI directors will be two of the three members of the Nominations Committee. Our certificate of incorporation includes provisions related to competition by RHI affiliates with Genentech, offering of corporate opportunities, transactions with interested parties, intercompany agreements, and provisions limiting the liability of specified employees. We cannot assure that RHI will not seek to influence our business in a manner that is contrary to our goals or strategies, or the interests of other stockholders. Moreover, persons who are directors of Genentech and who are also directors and/or officers of RHI may decline to take action in a manner that might be favorable to us but adverse to RHI.
Additionally, our certificate of incorporation provides that any person purchasing or acquiring an interest in shares of our capital stock shall be deemed to have consented to the provisions in the certificate of incorporation related to competition with RHI, conflicts of interest with RHI, the offer of corporate opportunities to RHI, and intercompany agreements with RHI. This deemed consent might restrict our ability to challenge transactions carried out in compliance with these provisions.
Our Affiliation Agreement with RHI could adversely affect our cash position.
Under our July 1999 Affiliation Agreement with RHI (Affiliation Agreement), we have established a stock repurchase program designed to maintain RHI’s percentage ownership interest in our Common Stock based on an established Minimum Percentage. The Affiliation Agreement provides that the percentage of our Common Stock owned by RHI could be up to 2% below the Minimum Percentage (subject to certain conditions). However, it also provides that, upon RHI’s request, we will repurchase shares of our Common Stock to increase RHI’s ownership to the Minimum Percentage. Such a request by RHI may adversely affect our cash position. Based on the trading price of our Common Stock and RHI’s approximate ownership percentage as of December 31, 2008, to raise RHI’s percentage ownership to the Minimum Percentage would require us to spend approximately $3 billion for share repurchases. Limitations in our ability to repurchase shares could result in further dilution, which could increase the number of shares required to be repurchased in order to raise RHI’s percentage ownership to the Minimum Percentage. For more information on our stock repurchase program, see “Liquidity and Capital Resources—Cash Used in Financing Activities,” in “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in Part II, Item 7 of this Form 10-K. For information on the Minimum Percentage, see Note 10, “Relationship with Roche Holdings, Inc. and Related Party Transactions,” in the Notes to Consolidated Financial Statements in Part II, Item 8 of this Form 10-K.
RHI’s ownership percentage is diluted by the exercise of stock options to purchase shares of our Common Stock by our employees and the purchase of shares of our Common Stock through our employee stock purchase plan. See Note 3, “Retention Plans and Employee Stock-Based Compensation,” in the Notes to Consolidated Financial Statements in Part II, Item 8 of this Form 10-K for information regarding employee stock plans. In order to maintain RHI’s Minimum Percentage, we repurchase shares of our Common Stock under the stock repurchase program. As of December 31, 2008, if all holders of exercisable in-the-money stock options had exercised their stock options, to offset dilution of such exercises would require us to spend approximately $2 billion for share repurchases, net of the exercise price of the stock options. In the first quarter of 2008, we received approximately four million shares under a $300 million prepaid share repurchase arrangement that we entered into and funded in 2007. In the second quarter of 2008, we entered into another prepaid share repurchase arrangement with an investment bank pursuant to which we delivered $500 million to the investment bank. Under this arrangement, the investment bank delivered approximately 5.5 million shares to us on September 30, 2008. As of December 31, 2008, there were in-the-money exercisable options outstanding for the purchase of approximately 45 million shares of Common Stock. While the cash outflows associated with future stock repurchase programs are uncertain, future stock repurchases could have a material adverse effect on our liquidity, credit rating, and ability to access additional capital in the financial markets.
Our Affiliation Agreement with RHI could limit our ability to make acquisitions or divestitures.
Our Affiliation Agreement with RHI contains provisions that:
| Ÿ | Require the approval of the directors designated by RHI to make any acquisition that represents 10 percent or more of our assets, net income, or revenue; or any sale or disposal of all or a portion of our business representing 10 percent or more of our assets, net income, or revenue. |
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| Ÿ | Enable RHI to maintain its percentage ownership interest in our Common Stock. |
| Ÿ | Require us to establish a stock repurchase program designed to maintain RHI’s percentage ownership interest in our Common Stock based on an established Minimum Percentage. For information regarding the Minimum Percentage, see Note 10, “Relationship with Roche Holdings, Inc. and Related Party Transactions,” in the Notes to Consolidated Financial Statements in Part II, Item 8 of this Form 10-K. |
Sales of our Common Stock by RHI could cause the price of our Common Stock to decline.
As of December 31, 2008, RHI owned 587,189,380 shares of our Common Stock, or 55.8% of our outstanding shares. All of our shares owned by RHI are eligible for sale in the public market subject to compliance with the applicable securities laws. We have agreed that, upon RHI’s request, we will file one or more registration statements under the Securities Act of 1933 in order to permit RHI to offer and sell shares of our Common Stock. Sales of a substantial number of shares of our Common Stock by RHI in the public market could adversely affect the market price of our Common Stock.
Our results of operations are affected by our royalty and contract revenue, and sales to collaborators.
Royalty and contract revenue, and sales to collaborators in future periods, could vary significantly. Major factors affecting this revenue include, but are not limited to:
| Ÿ | Roche’s decisions about whether to exercise its options and option extensions to develop and sell our future products in non-U.S. markets, and the timing and amount of any related development cost reimbursements. |
| Ÿ | The expiration or termination of existing arrangements with other companies and Roche, which may include development and marketing arrangements for our products in the U.S., Europe, and other countries. |
| Ÿ | The timing of non-U.S. approvals, if any, for products licensed to Roche and other licensees. |
| Ÿ | Government and third-party payer reimbursement and coverage decisions that affect the utilization of our products and competing products. |
| Ÿ | The initiation of new contractual arrangements with other companies. |
| Ÿ | Whether and when contract milestones are achieved. |
| Ÿ | The failure or refusal of a licensee to pay royalties or to make other contractual payments, the termination of a contract under which we receive royalties or other revenue, or changes to the terms of such a contract. |
| Ÿ | The expiration of, or an adverse legal decision or ruling with respect to, our patents or licensed intellectual property. See “Protecting our proprietary rights is difficult and costly” and the Cabilly patent litigation and re-examination discussion in Note 9, “Leases, Commitments, and Contingencies,” in the Notes to Consolidated Financial Statements in Part II, Item 8 of this Form 10-K. |
| Ÿ | Variations in Roche’s or other licensees’ sales of their licensed products due to competition, manufacturing difficulties, licensees’ internal forecasts, or other factors that affect the sales of products. |
| Ÿ | Variations in the recognition of royalty revenue based on our estimates of our licensees’ sales, which are difficult to forecast because of the number of products involved, the availability of licensee sales data, potential contractual and intellectual property disputes, and the volatility of foreign exchange rates. |
| Ÿ | Fluctuations in foreign currency exchange rates and the effect of any hedging contracts that we have entered into under our hedging policy. |
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| Ÿ | Negative safety or efficacy data from clinical studies conducted either in the U.S. or internationally by any party or post-approval marketing experience could cause the sales of our products to decrease or a product to be recalled or withdrawn. |
Other factors could affect our product sales.
Other factors that could affect our product sales financial conditioninclude, but are not limited to:
| Ÿ | Efficacy data from clinical studies conducted by any party in the U.S. or internationally showing, or perceived to show, a similar or improved treatment benefit at a lower dose or shorter duration of therapy could cause the sales of our products to decrease. |
| Ÿ | Our pricing decisions, including a decision to increase or decrease the price of a product; the pricing decisions of our competitors; as well as our Avastin Patient Assistance Program. |
| Ÿ | Negative safety or efficacy data from clinical studies conducted either in the U.S. or internationally by any party or post-approval marketing experience could cause the sales of our products to decrease or a product to be recalled or withdrawn. |
| Ÿ | The outcome of litigation involving patents of other companies concerning our products (or those of our collaborators) or processes related to production and formulation of those products or uses of those products. |
| Ÿ | Our distribution strategy, including the termination of, or change in, an existing arrangement with any major wholesalers that supply our products, and sales initiatives that we may undertake including product discounts. |
| Ÿ | Product returns and allowances greater than expected or historically experienced. |
| Ÿ | The inability of one or more of our major customers to maintain their ordering patterns or inventory levels, to efficiently and effectively distribute our products, or to meet their payment obligations to us on a timely basis or at all. |
| Ÿ | The inability of patients to afford co-pay costs due to an economic contraction or recession, increases in co-pay costs, or for any other reason. |
Any of the following additional factors could have a material adverse effect on our sales and results of operations.
We may be unable to attract and retain skilled personnel and maintain key relationshipsrelationships.
The success of our business depends, in large part, on our continued ability to (i)(1) attract and retain highly qualified management, scientific, manufacturing, and sales and marketing personnel, (ii)(2) successfully integrate large numbers of new employees into our corporate culture, and (iii)(3) develop and maintain important relationships with leading research and medical institutions and key distributors. Competition for these types of personnel and relationships is intense.
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the government. Interest rates and the ability to access credit markets could affect the ability of our customers/distributors to purchase, pay for, and effectively distribute our products. Similarly, these macroeconomic factors thatcould affect the ability of our sole-source or single-source suppliers to remain in business or otherwise supply product; failure by any of them to remain a going concern could affect our product sales include, but are not limited to:ability to manufacture products. Macroeconomic factors could also affect the ability of patients to pay for co-pay costs or otherwise pay for our products. Interest rates and the liquidity of the credit markets could also affect the value of our investments. Foreign currency exchange rates may affect our royalty revenue as well as the costs of R&D and manufacturing activities denominated in a currency other than the U.S. dollar.
We may incur material product liability costscosts.
The testing and marketing of medical products entailentails an inherent risk of product liability. Liability exposures for biotherapeutics couldpharmaceutical products can be extremely large and pose a material risk. Our business may be materially and adversely affected by a successful product liability claim or claims in excess of any insurance coverage that we may have.
Insurance coverage is increasinglymay be more difficult and costly to obtain or maintainmaintain.
We are subject to environmental and other risksrisks.
We use certain hazardous materials in connection with our research and manufacturing activities. In the event that such hazardous materials are stored, handled, or released into the environment in violation of law or any permit, we could be subject to loss of our permits, government fines or penalties, and/or other adverse governmental or private actions. The levy of a substantial fine or penalty, the payment of significant environmental remediation costs, or the loss of a permit or other authorization to operate or engage in our ordinary course of business could materially adversely affect our business.
We also have acquired, and may continue to acquire in the future, land and buildings as we expand our operations. Some of these properties are “brownfields” for which redevelopment or use is complicated by the presence or potential presence of a hazardous substance, pollutant, or contaminant. Certain events that could occur which may require us to pay significant clean-up or other costs in order to maintain our operations on those properties. Such events include, but are not limited to, changes in environmental laws, discovery of new contamination, or unintended exacerbation of existing contamination. The occurrence of any such event could materially affect our ability to continue our business operations on those properties.
Fluctuations in our operating results could affect the price of our Common StockStock.
Our operating results may vary from period to period for several reasons, including:including, but not limited to, the following:
| The overall competitive environment for our products, as described in “We face competition” above, factors affecting our royalty and contract revenue and sales to collaborators, as described in “Our results of operations are affected by our royalty and contract revenue, and sales to collaborators” above, and other factors that could affect our products sales as described in “Other factors could affect our product sales” above. |
| Ÿ |
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| Ÿ |
| Ÿ |
| The availability and extent of government and private third-party reimbursements for the cost of |
| The ability to successfully manufacture sufficient quantities of any particular marketed product. |
We may be unable to manufacture certain of our products if there is bovine spongiform encephalopathy (BSE) contamination of our bovine source raw material.
Portions of our information technology infrastructure, and those of our service providers, may experience interruptions, delays, or cessations of service, or produce errors. As part of our Enterprise Resource Planning efforts, we are implementing new information systems, but we may not be successful in implementing all of the new systems, and transitioning data and other aspects of the process could be expensive, time consuming, disruptive and resource intensive. Any disruptions that may occur in the implementation of new systemsto our current or any future systems, could adversely affect our ability to report in an accurate and timely manner the results of our consolidated operations, our financial position, and cash flows. Disruptions to these systems also could adversely affect our ability to fulfill orders and interrupt other operational processes. Delayed sales, lower margins, or lost customers resulting from these disruptions could adversely affect our financial results.
Our stock price, like that of many biotechnology companies, is volatilevolatile.
The market prices for securities of biotechnology companies in general have been highly volatile and may continue to be highly volatile in the future. In addition, the market price of our Common Stock has been and may continue to be volatile.
| Ÿ |
| Ÿ | Announcements of technological innovations or new commercial products by us or our competitors. |
| Publicity regarding actual or potential medical results |
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| Ÿ |
| Ÿ | Concerns about our pricing initiatives and distribution strategy, and the potential effect of such initiatives and strategy on the utilization of our products or our product sales. |
| Ÿ | Developments or |
| Regulatory developments or delays |
| Issues concerning the efficacy or safety of our products, or of biotechnology products generally. |
| Economic and other external factors or a disaster or crisis. |
| Ÿ |
Our effective income tax rate may vary significantlyvary.
Various internal and external factors may have favorable or unfavorable effects on our future effective income tax rate. These factors include, but are not limited to, changes in tax laws, regulations, and/or rates,rates; the results of any tax examinations; changing interpretations of existing tax laws or regulations,regulations; changes in estimates of prior years’ items,items; past and future levels of R&D spending,spending; acquisitions; changes in our corporate structure; and changes in overall levels of income before taxes.taxes—all of which may result in periodic revisions to our effective income tax rate.
As of December 31, 2005,2008, we had approximately $2.1$2.0 billion of long-term debt.debt and $500 million of commercial paper notes payable. Our ability to make payments on andor to refinance our indebtedness, including our long-term debt obligations, and to fund planned capital expenditures and R&D, as well as stock repurchases and expansion efforts, will depend on our ability to generate cash in the future. This ability, to a certain extent, is subject to general economic, financial, competitive, legislative, regulatory, and other factors that are and will remain beyond our control. Additionally, our indebtedness may increase our vulnerability to general adverse economic and industry conditions, and require us to dedicate a substantial portion of our cash flow from operations to payments on our indebtedness, which would reduce the availability of our cash flow to fund working capital, capital expenditures, R&D, expansion efforts, and other general corporate purposes,purposes; and limit our flexibility in planning for, or reacting to, changes in our business and the industry in which we operate.
Item 1B. |
None.
Item 2. |
Our headquarters facilities are located in a research and industrial area in South San Francisco, California, where we currently occupy 4335 owned and 515 leased buildings whichthat house our research and development,R&D, marketing and administrative activities, as well as bulk manufacturing facilities, a fill and fill/finish facility, and a warehouse. We have made and will continue to make improvements to these properties to accommodate our growth. We also have a commitment to lease an additional eight buildings which will begin occupancy in 2006. In addition, we own other propertyproperties in South San Francisco that we may utilize for future expansion.
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We own a manufacturing facility in Vacaville, California, whichthat is licensed to produce commercial quantities ofmaterials for select products. We are currently expandingexpanded our Vacaville site by constructing an additional manufacturing facility adjacent to the existing facility as well as office buildings to support the added manufacturing capacity. We expect construction, qualification and licensure of our new Vacaville plant by the end of 2009.
In September 2006, we acquired land in Hillsboro, Oregon for the construction of a new fill/finish, warehousing, distribution and related office facility. We completed construction and began warehousing and distribution operations in 2008. We expect FDA licensure of the fill/finish operation in late 2010.
We have an agreement with Lonza Group Ltd under which we can elect to purchase Lonza’s manufacturing facility currently under construction in Singapore. The facility is expected to be licensed for the production of Avastin bulk drug substance atin 2010.
In May 2007, we acquired land in Dixon, California and began the plantconstruction of a research support facility. We expect completion in late 2009.
In June 2007, we began construction of a new E. coli manufacturing facility in Singapore to commence in 2006 withproduce bulk drug substance of Lucentis and other E. coli derived products for the U.S. Food and Drug Administrationmarket. We anticipate FDA licensure anticipatedof the site in the first half of 2007.2010.
In connection with our acquisition of Tanox, Inc. in August 2007, we acquired a lease for a manufacturing plant in San Diego, California that has been certified by the FDA for clinical use.
We also lease additional officesmall facilities as regional offices for sales and marketing officesand other functions in several locations throughout the U.S., as well as in London, United States.
In general, our existing facilities, owned or leased, are in good condition and are adequate for all present and near termnear-term uses, and we believe that our capital resources are sufficient to purchase, lease, or construct any additional facilities required to meet our long-term growth needs.
Item 3. |
We are a party to various legal proceedings, including patent infringement litigation andlitigations, licensing and contract disputes, and other matters.
On October 4, 2004, we received a subpoena from the U.S. Department of Justice requesting documents related to the promotion of Rituxan, a prescription treatment now approved for the treatment of relapsed or refractory, low-grade or follicular, CD20 positive, B-cell non-Hodgkin’s lymphoma.five indications. We are cooperating with the associated investigation. Through counsel we are having discussions with government representatives about the status of their investigation which we haveand Genentech’s views on this matter, including potential resolution. Previously, the investigation had been advised is both civilcriminal and criminalcivil in nature. TheWe were informed in August 2008 by the criminal prosecutor who handled this matter that the government has informed us that it expectshad decided to call Genentech employeesdecline to appear before a grand juryprosecute the company criminally in connection with this investigation. The outcome of thiscivil matter cannot be determined at this time.
We and the City of Hope National Medical Center (or “COH”)(COH) are parties to a 1976 agreement relatingrelated to work conducted by two COH employees, Arthur Riggs and Keiichi Itakura, and patents that resulted from that work whichthat are referred to as the “Riggs/Itakura Patents.” Since that time,Subsequently, we have entered into license agreements with various companies to make,manufacture, use, and sell the products covered by the Riggs/Itakura Patents. On August 13, 1999, the COH filed a complaint against us in the Superior Court in Los Angeles County, California, alleging that we owe royalties to the COH in connection with these license agreements, as well as product license agreements that involve the grant of licenses under the Riggs/Itakura Patents. On June 10, 2002, a jury voted to award the COH approximately $300 million in compensatory damages. On June 24, 2002, a jury voted to award the COH an additional $200 million in punitive
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damages. Such amounts were accrued as an expense in the second quarter of 2002 and were included2002. Included within current liabilities in “Accrued litigation” in the accompanying consolidated balance sheets in “litigation-related and other long-term liabilities”Consolidated Balance Sheet at December 31, 2005 and December 31, 2004.2007 was $776 million, which represented our estimate of the costs for the resolution of the COH matter as of that reporting date. We filed a notice of appeal of the verdict and damages awards with the California Court of Appeal. On October 21, 2004,Appeal, and in subsequent proceedings the California Court of Appeal affirmed the verdict and damages awards in all respects. On November 22, 2004,Following the Californiadecision of the Court of Appeal, modified its opinion without changing the verdict and denied Genentech’s request for rehearing. On November 24, 2004, we filed a petition seeking review by the California Supreme Court. On February 2, 2005,Court which was granted, and on April 24, 2008 the California Supreme Court granted that petition. Theoverturned the award of $200 million in punitive damages to COH but upheld the award of $300 million in compensatory damages. We paid $476 million to COH in the second quarter of 2008, reflecting the amount of cash paid, if any, orcompensatory damages awarded plus interest thereon from the timing of such payment in connection with the COH matter will depend on the outcomedate of the California Supreme Court’s review of the matter; however, it may take longer than one year to further resolve the matter.original decision, June 10, 2002.
On April 11, 2003, MedImmune, Inc. (or “MedImmune”) filed a lawsuit against Genentech, COH, and Celltech R & D Ltd. in the U.S. District Court for the Central District of California (Los Angeles). The lawsuit relatesrelated to U.S. Patent No. 6,331,415 (or “the ‘415 patent” or “Cabilly patent”)(the Cabilly patent) that we co-own with COH and under which MedImmune and other companies have been licensed and are payinghave paid royalties to us.us under these licenses. The lawsuit includesincluded claims for violation of antitrust,anti-trust, patent, and unfair competition laws. MedImmune is seeking to havesought a ruling that the ‘415Cabilly patent declaredwas invalid and/or unenforceable, a determination that MedImmune doesdid not owe royalties under the ‘415Cabilly patent on sales of its Synagis®Synagis® antibody product, an injunction to prevent us from enforcing the ‘415Cabilly patent, an award of actual and exemplary damages, and other relief. On January 14, 2004 (amending a December 23, 2003 Order),June 11, 2008, we announced that we settled this litigation with MedImmune. Pursuant to the settlement agreement, the U.S. District
Court granted summary judgment in our favor ondismissed all of MedImmune’s antitrust and unfair competition claims. MedImmune sought to amend its complaint to reallege certainthe claims for antitrust and unfair competition. On February 19, 2004, the Court denied this motion in its entirety and final judgment was entered in favor of Genentech and Celltech and against MedImmune on March 15, 2004 on all antitrust and unfair competition claims. MedImmune filed a notice of appeal of this judgment with the U.S. Court of Appeals for the Federal Circuit. Concurrently,us in the District Courtlawsuit. The litigation we filed a motion to dismiss all remaining claims in the case. On April 23, 2004, the District Court granted our motionhas been fully resolved and dismissed, all remaining claims. Final judgment was enteredand the settlement did not have a material effect on our operating results in our favor on May 3, 2004, thus concluding proceedings in the District Court. On October 18, 2005, the U.S. Court of Appeals for the Federal Circuit affirmed the judgment of the District Court in all respects. MedImmune filed a petition for a writ of certiorari with the United States Supreme Court on November 22, 2005 and we filed our response on December 27, 2005. No decision on the petition has been issued.2008.
On May 13, 2005, a request was filed by a third party for reexamination of the ‘415 or Cabilly patent. The request sought reexamination on the basis of non-statutory double patenting over U.S. Patent No. 4,816,567. On July 7, 2005, the U.S. Patent Office ordered reexamination of the ‘415Cabilly patent. On September 13, 2005, the Patent Office issuedmailed an initial “non-final”non-final Patent Office action rejecting theall 36 claims of the ‘415Cabilly patent. This action is a routine and expected next step in the reexamination procedure. We filed our response to the Patent Office action on November 25, 2005. TheOn December 23, 2005, a second request for reexamination of the Cabilly patent was filed by another third party, and on January 23, 2006, the Patent Office has not yet actedgranted that request. On June 6, 2006, the two reexaminations were merged into one proceeding. On August 16, 2006, the Patent Office mailed a non-final Patent Office action in the merged proceeding rejecting all the claims of the Cabilly patent based on this response.issues raised in the two reexamination requests. We filed our response to the Patent Office action on October 30, 2006. On February 16, 2007, the Patent Office mailed a final Patent Office action rejecting all the claims of the Cabilly patent. We responded to the final Patent Office action on May 21, 2007 and requested continued reexamination. On May 31, 2007, the Patent Office granted the request for continued reexamination, and in doing so withdrew the finality of the February 2007 Patent Office action and agreed to treat our May 21, 2007 filing as a response to a first Patent Office action. On February 25, 2008, the Patent Office mailed a final Patent Office action rejecting all the claims of the Cabilly patent. We filed our response to that final Patent Office action on June 6, 2008. On July 19, 2008, the Patent Office mailed an advisory action replying to our response and confirming the rejection of all claims of the Cabilly patent. We filed a notice of appeal challenging the rejection on August 22, 2008. Our opening appeal brief was filed on December 9, 2008. Subsequent to the filing of our appeal brief, the Patent Office continued the reexamination. On February 12 and 13, 2009, we filed further responses with the Patent Office that included our proposed amendments to three claims of the patent (claims 21, 27, and 32). The reexamination process is ongoing. The ‘415Cabilly patent, which expires in
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2018, relates to methods that we and others use to make certain antibodies or antibody fragments, as well as cells and DNAdeoxyribonucleic acid (DNA) used in these methods. We have licensed the ‘415Cabilly patent to other companies and derive significant royalties from those licenses. The claims of the ‘415Cabilly patent remain valid and enforceable throughout the reexamination process.and appeals processes. The outcome of this matter cannot be determined at this time.
In 2006, we made development decisions involving our humanized anti-CD20 program, and our collaborator, Biogen Idec Inc., disagreed with certain of our development decisions related to humanized anti-CD20 products. Under our 2003 collaboration agreement with Biogen Idec, we believe that we are permitted to proceed with further trials of certain humanized anti-CD20 antibodies, but Biogen Idec disagreed with our position. The disputed issues have been submitted to arbitration. Resolution of the arbitration could require that both parties agree to certain development decisions before moving forward with humanized anti-CD20 antibody clinical trials (and possibly clinical trials of other collaboration products, including Rituxan), in which case we may have to alter or cancel planned clinical trials in order to obtain Biogen Idec’s approval. Each party is also seeking monetary damages from the other. The arbitrators held hearings on this matter, and we expect a final decision from the arbitrators by no later than July 2009. The outcome of this matter cannot be determined at this time.
On June 28, 2003, Mr. Ubaldo Bao Martinez filed a lawsuit against the Porriño Town Council and Genentech España S.L. in the Contentious Administrative Court Number One of Pontevedra, Spain. The lawsuit challenges the Town Council’s decision to grant licenses to Genentech España S.L. for the construction and operation of a warehouse and biopharmaceutical manufacturing facility in Porriño, Spain. On January 16, 2008, the Administrative Court ruled in favor of Mr. Bao on one of the claims in the lawsuit and ordered the closing and demolition of the facility, subject to certain further legal proceedings. On February 12, 2008, we and the Town Council filed appeals of the Administrative Court decision at the High Court in Galicia, Spain. In addition, through legal counsel in Spain we are cooperating with Lonza to pursue additional licenses and permits for the facility. We sold the assets of Genentech España S.L., including the Porriño facility, to Lonza in December 23, 2005,2006, and Lonza has operated the facility since that time. Under the terms of that sale, we retained control of the defense of this lawsuit and agreed to indemnify Lonza against certain contractually defined liabilities up to a secondspecified limit, which is currently estimated to be approximately $100 million. The outcome of this matter and our indemnification obligation to Lonza, if any, cannot be determined at this time.
On May 30, 2008, Centocor, Inc. filed a patent lawsuit against Genentech and COH in the U.S. District Court for the Central District of California. The lawsuit relates to the Cabilly patent that we co-own with COH and under which Centocor and other companies have been licensed and have paid royalties to us under these licenses. The lawsuit seeks a declaratory judgment of patent invalidity and unenforceability with regard to the Cabilly patent and of patent non-infringement with regard to Centocor’s marketed product ReoPro® (Abciximab) and its unapproved product CNTO 1275 (Ustekinumab). Centocor originally sought to recover the royalties that it has paid to Genentech for ReoPro® and the monies it alleges that Celltech has paid to Genentech for Remicade® (infliximab), a product marketed by Centocor (a wholly-owned subsidiary of Johnson & Johnson) under an agreement between Centocor and Celltech, but Centocor withdrew those claims in connection with its first amended complaint filed on September 3, 2008. Genentech answered the complaint on September 19, 2008 and also filed counterclaims against Centocor alleging that four Centocor products infringe certain Genentech patents. Genentech filed an amendment to those counterclaims on October 10, 2008 and Centocor answered these counterclaims on November 26, 2008. The outcome of this matter cannot be determined at this time.
On May 8, June 11, August 8, and September 29 of 2008, Genentech was named as a defendant, along with InterMune, Inc. and its former chief executive officer, W. Scott Harkonen, in four originally separate class-action complaints filed in the U.S. District Court for the Northern District of California on behalf of plaintiffs who allegedly paid part or all of the purchase price for Actimmune® for the treatment of idiopathic pulmonary fibrosis. Actimmune® is an interferon-gamma product that was licensed by Genentech to Connectics Corporation and was subsequently assigned to InterMune. InterMune currently sells Actimmune® in the U.S. The complaints are related in part to royalties that we received in connection with the Actimmune® product. The May 8, June 11, and August 8 complaints have been consolidated into a single amended complaint that claims and seeks damages for violations of
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federal racketeering laws, unfair competition laws, and consumer protection laws, and for unjust enrichment. The September 29 complaint includes six claims, but only names Genentech as a defendant in one claim for damages for unjust enrichment. Genentech’s motion to dismiss both complaints was heard on February 2, 2009. The outcome of these matters cannot be determined at this time.
Subsequent to the Roche Proposal, more than thirty shareholder lawsuits have been filed against Genentech and/or the members of its Board of Directors, and various Roche entities, including RHI, Roche Holding AG, and Roche Holding Ltd. The lawsuits are currently pending in various state courts, including the Delaware Court of Chancery and San Mateo County Superior Court, as well as in the United States District Court for the Northern District of California. The lawsuits generally assert class-action claims for breach of fiduciary duty and aiding and abetting breaches of fiduciary duty based in part on allegations that, in connection with Roche’s offer to purchase the remaining shares, some or all of the defendants failed to properly value Genentech, failed to solicit other potential acquirers, and are engaged in improper self-dealing. Several of the suits also seek the invalidation, in whole or in part, of the Affiliation Agreement, and an order deeming Articles 8 and 9 of the company’s Amended and Restated Certificate of Incorporation invalid or inapplicable to a potential transaction with Roche. The outcome of these matters cannot be determined at this time.
On October 27, 2008, Genentech and Biogen Idec Inc. filed a complaint against Sanofi-Aventis Deutschland GmbH (Sanofi), Sanofi-Aventis U.S. LLC, and Sanofi-Aventis U.S. Inc. in the Northern District of California, seeking a declaratory judgment that certain Genentech products, including Rituxan (which is co-marketed with Biogen Idec) do not infringe Sanofi’s U.S. Patents 5,849,522 (‘522 patent) and 6,218,140 (‘140 patent) and a declaratory judgment that the ‘522 and ‘140 patents are invalid. Also on October 27, 2008, Sanofi filed suit against Genentech and Biogen Idec in the Eastern District of Texas, Lufkin Division, claiming that Rituxan and at least eight other Genentech products infringe the ‘522 and ‘140 patents. Sanofi is seeking preliminary and permanent injunctions, compensatory and exemplary damages, and other relief. Genentech and Biogen Idec filed a motion to transfer this matter to the Northern District of California on January 22, 2009. In addition, on October 24, 2008, Hoechst GmbH filed with the ICC International Court of Arbitration (Paris) a request for reexaminationarbitration with Genentech, relating to a terminated agreement between Hoechst’s predecessor and Genentech that pertained to the above-referenced patents and related patents outside the U.S. Hoechst is seeking payment of the ‘415 patent was filed by another third party. On January 23, 2006, the Patent Office granted the reexamination request. Because the second requestroyalties on sales of Genentech products, damages for reexaminationbreach of contract, and the above-described reexamination proceeding are ongoing, the finalother relief. Genentech intends to defend itself vigorously. The outcome of these matters cannot be determined at this time.
Not applicable.
Executive Officers of the Company
The executive officers of the Companycompany and their respective ages (ages as(as of December 31, 2005)2008) and positions with the Companycompany are as follows:
Name | Age | Position | |
Arthur D. Levinson, Ph.D.* | Chairman and Chief Executive Officer | ||
Susan D. Desmond-Hellmann, M.D., M.P.H.* | President, Product Development | ||
Ian T. Clark* | Executive Vice President, Commercial Operations | ||
David A. Ebersman* | Executive Vice President and Chief Financial Officer | ||
Stephen G. Juelsgaard, D.V.M., J.D.* | Executive Vice President, | ||
Richard H. Scheller, Ph.D.* | Executive Vice President, Research and Chief Scientific Officer | ||
Patrick Y. Yang, Ph.D.* | Executive Vice President, Product Operations | ||
Executive Vice President, Research Drug Discovery | |||
| Hal Barron, M.D., F.A.C.C. | 46 | Senior Vice President, | |
Vice President, Controller and Chief Accounting Officer |
* Members of the Executive Committee of the Company.company.
The Board of Directors appoints all executive officers annually. There is no family relationship between or among any of the executive officers or directors.
Business Experience
Arthur D. Levinson, Ph.D. was appointed Chairman of the Board of Directors of Genentech, Inc. in September 1999 and was elected its Chief Executive Officer and a director of the Companycompany in July 1995. Since joining the Companycompany in 1980, Dr. Levinson has been a Senior Scientist, Staff Scientist and the Director of the Company’scompany’s Cell Genetics Department. Dr. Levinson was appointed Vice President of Research Technology in April 1989, Vice President of Research in May 1990, Senior Vice President of Research in December 1992, and Senior Vice President of Research and Development in March 1993 and President in July 1995.1993. Dr. Levinson also serves as a member of the Board of Directors of Apple, Computer, Inc. and Google, Inc.
Susan D. Desmond-Hellmann, M.D., M.P.H. was appointed President, Product Development of Genentech in March 2004. She previously served as Executive Vice President, Development and Product Operations from September 1999 to March 2004, Chief Medical Officer from December 1996 to March 2004, and as Senior Vice President, Development from December 1997 to September 1999, among other positions, since joining Genentech in March 1995 as a Clinical Scientist. Prior to joining Genentech, she held the position of Associate Director at Bristol-Myers Squibb. Dr. Hellmann also serves as a member of the Board of Directors of Affymetrix, Inc.
Ian T. Clark was appointed Executive Vice President, Commercial Operations of Genentech in December 2005. He previously served as Senior Vice President, Commercial Operations of Genentech from August 2005 to December 2005 and joined Genentech as Senior Vice President and General Manager, BioOncology and served in that role from January 2003 through August 2005. Prior to joining Genentech, he served as president for Novartis Canada from 2001 to 2003. Before assuming his post in Canada, he served as chief operating officer for Novartis United Kingdom from 1999 to 2001. Mr. Clark also serves as a member of the Board of Directors of Vernalis plc.
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David A. Ebersman was appointed Executive Vice President of Genentech in December 2005January 2006 and Chief Financial Officer in March 2005. Previously, he served as Senior Vice President, Finance from January 2005 through March 2005 and Senior Vice President, Product Operations from May 2001 through January 2005. He joined Genentech in February 1994 as a Business Development Analyst and subsequently served as Manager, Business Development from February 1995 to February 1996, Director, Business Development from February 1996 to March 1998, Senior Director, Product Development from March 1998 to February 1999 and Vice President, Product Development from February 1999 to May 2001. Prior to joining Genentech, he held the position of Research Analyst at Oppenheimer & Company, Inc.
Stephen G. Juelsgaard, D.V.M., J.D. was appointed Chief Compliance Officer of Genentech in June 2005, Executive Vice President in September 2002, Vice President and General Counsel in July 1994 and Secretary in April 1997. He joined Genentech in July 1985 as Corporate Counsel and subsequently served as Senior Corporate Counsel from 1988 to 1990, Chief Corporate Counsel from 1990 to 1993, Vice President, Corporate Law from 1993 to 1994, Assistant Secretary from 1994 to 1997, and Senior Vice President from April 1998 to September 2002.2002, and General Counsel from 1994 to January 2007.
Richard H. Scheller, Ph.D. was appointed Executive Vice President, Research of Genentech in September 2003.2003 and Chief Scientific Officer in June 2008. Previously, he served as Senior Vice President, Research from March 2001 to September 2003. Prior to joining Genentech, he served as Professor of Molecular and Cellular Physiology and of Biological Sciences at Stanford University Medical Center from September 1982 to February 2001 and as an investigatorInvestigator at the Howard Hughes Medical Institute from September 1990 to February 2001. He received his first academic appointment to Stanford University in 1982. He was appointed to the esteemed position of professorProfessor of Molecular and Cellular Physiology in 1993 and as an investigatorInvestigator in the Howard Hughes Medical Institute in 1994.
Patrick Y. Yang, Ph.D. was appointed Executive Vice President, Product Operations of Genentech in December 2005. Previously, he served as Senior Vice President, Product Operations from January 2005 through December 2005 and Vice President, South San Francisco Manufacturing and Engineering from December 2003 to January 2005. Prior to joining Genentech, he worked for General Electric from 1980 to 1992 in manufacturing and technology and for Merck & Co. Inc. from 1992 to 2003 in manufacturing. At Merck, he held several executive positions including Vice President, Supply Chain Management from 2001 to 2003 and Vice President, Asia/Pacific Manufacturing Operations from 1997 to 2000.
Hal Barron, M.D., F.A.C.C. was named Senior Vice President, Development in February 2001. Previously, heJanuary 2004 and Chief Medical Officer in March 2004. He previously served as Vice President Regulatoryof Medical Affairs from February 1998May 2002 to February 2001, Vice President, Quality from April 1994 to February 1998,January 2004, and as Senior Director Quality Controlof Specialty BioTherapeutics from 19902001 to 19942002. Prior to that, he held positions as Associate Director and Director Quality Control from 1988 to 1990. Heof Cardiovascular Research. Dr. Barron joined Genentech as a clinical scientist in August 1984 from Armour Pharmaceutical, where he held various positions.1996.
PART II
See "Liquidity“Liquidity and Capital Resources — Resources—Cash Provided by or Used in Financing Activities"Activities” in "Management’s“Management’s Discussion and Analysis of Financial Condition and Results of Operations" ofOperations” in Part II, Item 7 of this Form 10-K,10-K; Note 1, “Description of Business — Business—Redemption of Our Special Common Stock,”Stock”; Note 8,10, “Relationship with Roche Holdings, Inc. and Related Party Transactions,”Transactions”; and Note 9,12, “Capital Stock,” in the Notes to Consolidated Financial Statements ofin Part II, Item 8 of this Form 10-K.
Stock Exchange Listing
Our Common Stock trades on the New York Stock Exchange under the symbol “DNA.” NoWe have not paid dividends have been paid on theour Common Stock. We currently intend to retain all future income for use in the operation of our business and for future stock repurchases and, therefore, do not anticipate paying anywe have no plans to pay cash dividends in the near future.at this time.
Common Stockholders
As of December 31, 2005,2008, there were approximately 2,3502,100 stockholders of record of our Common Stock, one of which is Cede & Co., a nominee for Depository Trust Company (or “DTC”)(DTC). All of the shares of Common Stock held by brokerage firms, banks and other financial institutions as nominees for beneficial owners are deposited into participant accounts at DTC, and are therefore considered to be held of record by Cede & Co. as one stockholder.
Stock Prices
Common Stock | |||||||||||||
2005 | 2004 | ||||||||||||
High | Low | High | Low | ||||||||||
| 4th Quarter | $ | 100.20 | $ | 79.87 | $ | 55.98 | $ | 41.00 | |||||
| 3rd Quarter | 94.99 | 79.71 | 56.61 | 43.00 | |||||||||
| 2nd Quarter | 84.10 | 54.68 | 68.25 | 50.11 | |||||||||
| 1st Quarter | 59.00 | 43.90 | 56.98 | 44.74 | |||||||||
Common Stock | ||||||||||||||||
2008 | 2007 | |||||||||||||||
High | Low | High | Low | |||||||||||||
| 4th Quarter | $ | 89.77 | $ | 69.17 | $ | 78.61 | $ | 65.35 | ||||||||
| 3rd Quarter | 99.14 | 75.01 | 80.57 | 71.43 | ||||||||||||
| 2nd Quarter | 82.00 | 66.80 | 83.65 | 72.31 | ||||||||||||
| 1st Quarter | 82.20 | 65.60 | 89.73 | 80.12 | ||||||||||||
Stock Repurchases
See "Liquidity“Liquidity and Capital Resources — Resources—Cash Provided by or Used in Financing Activities"Activities” in "Management’s“Management’s Discussion and Analysis of Financial Condition and Results of Operations" ofOperations” in Part II, Item 7 of this Form 10-K for information on our stock repurchases.
Performance Graph
Below is a graph showing the cumulative total return to our stockholders during the period from December 31, 2003 through December 31, 2008 in comparison to the cumulative return on the Standard & Poor’s 500 Index, the Standard & Poor’s 500 Pharmaceuticals Index, and the Standard & Poor’s 500 Biotechnology Index during that same period.(1) The results assume that $100 was invested on December 31, 2003.
| Base Period | Years Ending | |||||||||||||||||||||||
| December | December | December | December | December | December | |||||||||||||||||||
Company / Index | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | ||||||||||||||||||
| Genentech, Inc. | $ | 100 | $ | 116.36 | $ | 197.71 | $ | 173.41 | $ | 143.36 | $ | 177.21 | ||||||||||||
| S&P 500 Index | 100 | 110.88 | 116.33 | 134.70 | 142.10 | 89.53 | ||||||||||||||||||
| S&P 500 Pharmaceuticals Index | 100 | 92.57 | 89.46 | 103.64 | 108.47 | 88.73 | ||||||||||||||||||
| S&P 500 Biotechnology Index | 100 | 107.61 | 127.27 | 123.78 | 119.55 | 131.88 | ||||||||||||||||||
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| (1) | The total return on investment (the change in year-end stock price plus reinvested dividends) assumes $100 invested on December 31, 2003 in our Common Stock, the Standard & Poor’s 500 Index, the Standard & Poor’s 500 Pharmaceuticals Index and the Standard & Poor’s 500 Biotechnology Index. At December 31, 2008, the Standard & Poor’s 500 Pharmaceuticals Index comprised Abbott Laboratories; Allergan, Inc.; Bristol-Myers Squibb Company; Forest Laboratories, Inc.; Johnson & Johnson; King Pharmaceuticals, Inc.; Merck & Co., Inc.; Mylan Laboratories Inc.; Eli Lilly and Company; Pfizer Inc.; Schering-Plough Corporation; Watson Pharmaceuticals, Inc.; and Wyeth. At December 31, 2008, the Standard & Poor’s 500 Biotechnology Index comprised Amgen Inc.; Biogen Idec Inc.; Celgene Corporation; Cephalon, Inc.; Genzyme Corporation; and Gilead Sciences, Inc. |
| The information under “Performance Graph” is not deemed filed with the Securities and Exchange Commission and is not to be incorporated by reference in any filing of Genentech under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, whether made before or after the date of this 10-K and irrespective of any general incorporation language in those filings. | |
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Item 6. |
The following selected consolidated financial informationdata has been derived from theour audited consolidated financial statements. The information below is not necessarily indicative of the results of future operations and should be read in conjunction with Item 7, “Management’s Discussion and Analysis of Financial Condition and Results of Operations”Operations,” and Item 1A, “Risk Factors,” of this Form 10-K, and the consolidated financial statements and related notes thereto included in Item 8 of this Form 10-K, in order to fully understand factors that may affect the comparability of the information presented below.
SELECTED CONSOLIDATED FINANCIAL DATA
(inIn millions, except per share amounts)
2005 | 2004 | 2003 | 2002 | 2001 | 2008 | 2007 | 2006 | 2005 | 2004 | ||||||||||||||||||||||||||||||||||||||
| Total operating revenues | $ | 6,633.4 | $ | 4,621.2 | $ | 3,300.2 | $ | 2,583.7 | $ | 2,044.1 | |||||||||||||||||||||||||||||||||||||
| Total operating revenue | $ | 13,418 | $ | 11,724 | $ | 9,284 | $ | 6,633 | $ | 4,621 | |||||||||||||||||||||||||||||||||||||
| Product sales | 5,488.1 | 3,748.9 | 2,621.4 | 2,163.6 | 1,742.9 | 10,531 | 9,443 | 7,640 | 5,488 | 3,749 | |||||||||||||||||||||||||||||||||||||
| Royalties | 935.1 | 641.1 | 500.9 | 365.6 | 264.5 | 2,539 | 1,984 | 1,354 | 935 | 641 | |||||||||||||||||||||||||||||||||||||
| Contract revenue | 210.2 | 231.2 | 177.9 | 54.5 | 36.7 | 348 | 297 | 290 | 210 | 231 | |||||||||||||||||||||||||||||||||||||
| Income before cumulative effect of accounting changes | $ | 1,279.0 | $ | 784.8 | $ | 610.1 | $ | 63.8 | $ | 155.9 | |||||||||||||||||||||||||||||||||||||
| Cumulative effect of accounting changes, net of tax | - | - | (47.6 | )(6) | - | (5.6 | )(9) | ||||||||||||||||||||||||||||||||||||||||
Net income(1) | $ | 1,279.0 | (2) | $ | 784.8 | (5) | $ | 562.5 | (6) | $ | 63.8 | (8) | $ | 150.3 | (9) | ||||||||||||||||||||||||||||||||
| Net income | $ | 3,427 | (1) | $ | 2,769 | (1) | $ | 2,113 | (1) | $ | 1,279 | $ | 785 | ||||||||||||||||||||||||||||||||||
| Basic earnings per share | $ | 1.21 | $ | 0.74 | $ | 0.54 | $ | 0.06 | $ | 0.14 | $ | 3.25 | $ | 2.63 | $ | 2.01 | $ | 1.21 | $ | 0.74 | |||||||||||||||||||||||||||
| Diluted earnings per share | 1.18 | 0.73 | 0.53 | 0.06 | 0.14 | 3.21 | 2.59 | 1.97 | 1.18 | 0.73 | |||||||||||||||||||||||||||||||||||||
| Total assets | $ | 12,146.9 | $ | 9,403.4 | (4) | $ | 8,759.5 | (4) | $ | 6,775.5 | $ | 7,161.5 | $ | 21,787 | $ | 18,940 | $ | 14,842 | $ | 12,147 | $ | 9,403 | (2) | ||||||||||||||||||||||||
| Long-term debt | 2,083.0 | (3) | 412.3 | (4) | 412.3 | (4) | - | (7) | - | (7) | 2,329 | (2) | 2,402 | (2) | 2,204 | (2) | 2,083 | (2) | 412 | (2) | |||||||||||||||||||||||||||
| Stockholders’ equity | 7,469.6 | 6,782.2 | 6,520.3 | 5,338.9 | 5,919.8 | 15,671 | 11,905 | 9,478 | 7,470 | 6,782 | |||||||||||||||||||||||||||||||||||||
| We have not paid | |
| All per share amounts reflect the two-for-one stock split that was effected in 2004. | |
| (1) | Net income |
Long-term debt in 2008, 2007, 2006, and 2005 included $2 billion related to our debt issuance in July 2005, and | |
| Upon adoption of | |
Overview
The Company
Genentech is a leading biotechnology company that discovers, develops, manufactures, and commercializes biotherapeuticsmedicines for patients with significant unmet medical needs. We commercialize multiple biotechnology products and also receive royalties from companies that are licensed to market products based on our technology.
Major Developments in 20052008
We primarily earn revenue and income, and generate cash from product sales and royalty revenue. Our total operating revenuesrevenue in 2005 were $6.632008 was $13.42 billion, an increase of 44%14% from $4.62$11.72 billion in 2004.2007. Product sales in 2008 were $10.53 billion, an increase of 12% from $9.44 billion in 2007. Product sales represented 78% of our operating revenue in 2008 and 81% in 2007. Royalty revenue was $2.54 billion in 2008, an increase of 28% from $1.98 billion in 2007. Royalty revenue represented 19% of our operating revenue in 2008 and 17% in 2007. Our net income in 20052008 was $1.28$3.43 billion, an increase of 63%24% from $784.8 million$2.77 billion in 2004.2007.
On February 12, 2008, we announced positive datathat AVADO, Roche’s study evaluating two doses of Avastin in first-line metastatic breast cancer (BC), met its primary endpoint of prolonging progression-free survival (PFS). Both doses of Avastin in combination with chemotherapy showed statistically significant improvement in the time patients lived without their disease advancing compared to chemotherapy and placebo.
On February 22, 2008, we received accelerated approval from eight Phase III clinical trials and we, in certain instances with our collaborators OSI or Biogen Idec, submitted several filings to the U.S.U.S Food and Drug Administration (or “FDA”) including: (i)(FDA) to market Avastin for use in combination with 5-fluorouracil (or “5-FU”)-basedpaclitaxel chemotherapy for the treatment of patients with relapsed,who have not received prior chemotherapy for metastatic colorectal cancer; (ii) Rituxanhuman epidermal growth factor receptor 2 (HER2)-negative BC. As a condition of the accelerated approval, we are required to treat front-line intermediate grade or aggressive non-Hodgkin’s lymphoma (or “NHL”), which was approved bymake future submissions to the FDA, including the final study reports for two Phase III studies, AVADO and RIBBON I, which are studies of Avastin in first-line metastatic HER2-negative BC. Based on February 10, 2006; (iii) Rituxanthe FDA’s review of our future submissions, the FDA may decide to treat patients with active rheumatoid arthritis (or “RA”) who inadequately respondwithdraw or modify the accelerated approval, request additional post-marketing studies, or grant full approval.
On April 20, 2008, we announced an update to anti-tumor necrosis factor therapy; (iv) Tarceva for usethe previously reported Roche-sponsored international Phase III clinical study of Avastin (AVAiL) in combination with gemcitabine and cisplatin chemotherapy in patients with advanced, non-squamous, non-small cell lung cancer (NSCLC). The update confirmed the statistically significant improvement in the primary endpoint of PFS for the first-line treatmenttwo different doses of Avastin studied in the trial (15 mg/kg/every-three-weeks and 7.5 mg/kg/every-three-weeks) compared to chemotherapy alone. The study did not demonstrate a statistically significant prolongation of overall survival, a secondary endpoint, for either dose of Avastin in combination with gemcitabine and cisplatin chemotherapy compared to chemotherapy alone. Median survival of patients in all arms of the study exceeded one year, longer than previously reported survival times in this indication.
On November 3, 2008, we announced that we submitted a supplemental Biologic License Application (sBLA) to the FDA for Avastin as a therapy for patients with locally advanced, unresectable or metastatic pancreatic cancer, which was approvedpreviously treated glioblastoma. If accepted by the FDA, in November 2005; and (v) Lucentis (ranibizumab)the application would be considered for an accelerated approval that allows provisional approval of medicines for cancer or other life-threatening diseases based on preliminary evidence suggesting clinical benefit. We plan to treat neovascular wet form age-related macular degeneration (or “AMD”).
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On November 23, 2008, we announced that a Phase III study (RIBBON I) of Avastin, in combination with taxane, anthracycline-based or capecitabine chemotherapies for first-line treatment of metastatic HER2-negative BC, met its primary endpoint of increasing the time patients lived without their disease advancing, compared to the chemotherapies alone. The primary endpoint of PFS was assessed by the treating physicians in the study (investigator-assessed). The safety profile of Avastin was consistent with previous experience and no new safety signals were observed.
The National Surgical Adjuvant Breast and Bowel Project (NSABP) is sponsoring an ongoing Phase III study (NSABP C-08) of Avastin plus chemotherapy in patients with early-stage colon cancer. During 2008, we announced that the NSABP informed us that the trial would continue, based on recommendations from an independent data monitoring committee after planned interim analyses and that the final efficacy and safety results were expected to be available in 2009 rather than 2010 as was previously anticipated. We also announced that the interim analyses showed no new or unexpected safety events in the Avastin arm. On January 21, 2009, we announced that the NSABP informed us that the results of the study could be known and communicated as early as mid-April 2009. The exact timing of data availability will depend on the timing of disease progression events. If the required number of disease progression events as defined by the study’s statistical analytical plan has not occurred as of mid-April, then the NSABP will continue the study and we anticipate that the final results will most likely be known later in the second quarter of 2009.
Rituxan
On July 18, 2005,April 14, 2008, we completedand Biogen Idec announced that OLYMPUS, a private placementPhase II/III study of Rituxan for primary-progressive multiple sclerosis (PPMS), did not meet its primary endpoint as measured by the time to confirmed disease progression during the 96-week treatment period.
On April 29, 2008, we announced that the Phase II/III study of Rituxan for systemic lupus erythematosus (SLE, commonly called lupus) did not meet its primary endpoint, defined as the proportion of Rituxan treated patients who achieved a major clinical response or partial clinical response measured by British Isles Lupus Assessment Group, a lupus activity response index, compared to placebo at 52 weeks.
On October 6, 2008, we and Biogen Idec announced that a global Phase III study of Rituxan in combination with fludarabine and cyclophosphamide chemotherapy met its primary endpoint of improving PFS, as assessed by investigators, in patients with previously treated CD20-positive chronic lymphocytic leukemia (CLL) compared to chemotherapy alone. There were no new or unexpected safety signals reported in the study. An independent review of the primary endpoint is being conducted for United States (U.S.) regulatory purposes. Earlier in 2008, Roche announced that another Phase III study of Rituxan, CLL-8, showed that a similar treatment combination improved PFS in patients with CLL who had not previously received treatment.
On December 18, 2008 we and Biogen Idec announced that a Phase III clinical study of Rituxan (IMAGE) in patients with early rheumatoid arthritis (RA) who were not previously treated with methotrexate met its primary endpoint.
Other Products and Pipeline
On October 2, 2008, we announced that we issued a Dear Healthcare Provider letter to inform physicians of a case of progressive multifocal leukoencephalopathy (PML) in a 70-year-old patient who had received Raptiva for more than four years for treatment of chronic plaque psoriasis. The patient subsequently died. On October 16, 2008, revised prescribing information for Raptiva was approved by the FDA. A boxed warning was added that includes the recently reported case of PML and updated information on the risk of serious infections leading to hospitalizations and death in patients receiving Raptiva. The updated label also includes a warning about certain neurologic events as well as precautions regarding immunizations and pediatric use. A Dear Healthcare Provider letter was issued to communicate this updated prescribing information to physicians. On November 17, 2008, we announced that we issued a Dear Healthcare Provider letter to inform physicians of a second case of PML that resulted in the death of a
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73-year old patient who had received Raptiva for approximately four years for treatment of chronic plaque psoriasis. On February 10, 2009, a Dear Healthcare Provider letter was sent to physicians to inform them of a third case of PML in a 47-year-old patient who had received Raptiva for more than three years for the treatment of chronic plaque psoriasis. On February 19, 2009, our collaborator, Merck Serono, and separately the European Medicines Agency (EMEA), announced that the EMEA recommended the suspension of the marketing authorization for Raptiva from Merck Serono, and that the EMEA’s Committee for Medicinal Products for Human Use (CHMP) has concluded that the benefits of Raptiva no longer outweigh its risks because of safety concerns, including the occurrence of PML in patients taking the medicine. Also on February 19, 2009, the FDA issued a public health advisory regarding Raptiva, which provided warnings about PML and the use of Raptiva, and advised physicians to periodically re-evaluate patients treated with Raptiva and to consider other approved therapies to control patients’ psoriasis. Based on the medical information available for the PML cases, we believe that Raptiva increases the risk of PML and that prolonged exposure to Raptiva or older age may further increase this risk. We have submitted updated labeling to the FDA, and are working with the FDA to determine the appropriate next steps, which may include, among other things, significant restrictions in use of or suspension or withdrawal of regulatory approval for Raptiva.
On October 2, 2008, we announced that we entered into a collaboration agreement with Roche and GlycArt Biotechnology AG (wholly-owned by Roche) in September for the joint development and commercialization of GA101, a humanized anti-CD20 monoclonal antibody for the potential treatment of hematological malignancies and other oncology-related B-cell disorders such as non-Hodgkin’s lymphoma (NHL). GA101 is currently in Phase I/II clinical trials for CD20-positive B-cell malignancies, such as NHL and CLL. On October 28, 2008, Biogen Idec exercised their right under our collaboration agreement with them to opt in to this agreement and paid us an up-front fee as part of the opt-in.
On October 5, 2008, we and OSI Pharmaceuticals announced that a randomized Phase III study (BeTa Lung) evaluating Avastin in combination with Tarceva in patients with advanced NSCLC whose disease had progressed following debt instruments: $500.0platinum-based chemotherapy did not meet its primary endpoint of improving overall survival compared to Tarceva in combination with a placebo. However, there was evidence of clinical activity with improvements in the secondary endpoints of PFS and response rate when Avastin was added to Tarceva compared to Tarceva alone. No new or unexpected safety signals for either Avastin or Tarceva were observed in the study, and adverse events were consistent with those observed in previous NSCLC clinical trials evaluating the agents.
On November 6, 2008, we and OSI Pharmaceuticals announced that a global Phase III study (SATURN) met its primary endpoint and showed that Tarceva significantly extended the time that patients with advanced NSCLC lived without their cancer getting worse when given Tarceva immediately following initial treatment with platinum-based chemotherapy, compared to placebo. There were no new or unexpected safety signals in the study and adverse events were consistent with those observed in previous NSCLC clinical trials evaluating Tarceva.
On February 2, 2009, we announced that a Phase III study (ATLAS) of Tarceva in combination with Avastin as maintenance therapy following initial treatment with Avastin plus chemotherapy in advanced NSCLC met its primary endpoint. The study was stopped early on the recommendation of an independent data safety monitoring board after a pre-planned interim analysis showed that combining Tarceva and Avastin significantly extended the time patients lived without their disease advancing, as defined by PFS, compared to Avastin plus placebo. A preliminary safety analysis showed that adverse events were consistent with previous Avastin or Tarceva studies, as well as trials evaluating the two medicines together, and no new safety signals were observed.
Legal and Other Matters
On February 25, 2008, the U.S. Patent and Trademark Office (Patent Office) issued a final Patent Office action rejecting all 36 claims of the Cabilly patent. We filed our response to that final Patent Office action on June 6, 2008. On July 19, 2008, the Patent Office mailed an advisory action replying to our response and confirming the rejection of all claims of the Cabilly patent. We filed a notice of appeal challenging the rejection on August 22, 2008. Our opening appeal brief was filed on December 9, 2008. Subsequent to the filing of our appeal brief, the Patent Office continued the reexamination. On February 12 and 13, 2009, we filed further responses with the Patent Office that included our proposed amendments to three claims of the patent (claims 21, 27, and 32). The claims of the patent remain valid and enforceable throughout the reexamination and appeals processes.
On April 24, 2008, we announced that the California Supreme Court overturned the award of $200 million principalin punitive damages to the COH but upheld the award of $300 million in compensatory damages resulting from a contract dispute brought by COH. The punitive damages were part of a 2004 decision of the California Court of Appeal, which upheld a 2002 Los Angeles County Superior Court jury verdict awarding these amounts. We paid $476 million to COH in the second quarter of 2008, reflecting the amount of 4.40% Senior Notes due 2010, $1.0 billion principal amountcompensatory damages awarded, plus interest thereon from the date of 4.75% Senior Notes due 2015 and $500.0 million principal amountthe original decision in 2002. We recorded a favorable litigation settlement as a result of 5.25% Senior Notes due 2035. We received approximately $1.99 billion in net proceeds from this offering, after deducting selling and offering expenses.the California Supreme Court decision.
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On June 11, 2008, we announced that we settled the patent litigation with MedImmune involving the Cabilly patent. The settlement resolved disputed issues with respect to MedImmune’s marketed product Synagis® as well as a related product for which MedImmune is seeking regulatory approval. The settlement also permits MedImmune to obtain licenses for certain additional pipeline products under the Cabilly patent family.
Our Strategy and Goals
As announced in 2006, our business plan. We exceeded our most important goal of average annual non-GAAP EPS growth. We exceeded our goal of five significant products/indications in late stageobjectives for the years 2006 through 2010 include bringing at least 20 new molecules into clinical development, and have exceeded our goal of fivebringing at least 15 major new products or indications approved through 2005. We did not meetonto the market, becoming the number one U.S. oncology company in sales, and achieving certain financial growth measures. These objectives are reflected in our goal of $500 million in new revenue from alliances and/or acquisitions. We did not meet our non-GAAP net income as a percentage of total operating revenues goal, due primarily to the success of Rituxan, net of the associated profit split with Biogen Idec. Information on our 5x5 plan can be foundrevised Horizon 2010 strategy and goals summarized on our website at http://www.gene.com.www.gene.com/gene/about/corporate/growthstrategy.
Economic and Industry-wide Factors
Our goalsstrategy and objectivesgoals are challenged by economic and industry-wide factors that affect our business. Some of the most importantKey factors that affect our future growth are discussed below:below.
| Ÿ |
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| Ÿ | Our long-term business growth depends on our ability to continue to successfully develop and commercialize important novel therapeutics to treat unmet medical needs. We recognize that the successful development of pharmaceutical products is highly difficult and uncertain, and that it will be challenging for us to continue to discover and develop innovative treatments. Our business requires significant |
| Ÿ |
| Ÿ | As the Medicare and Medicaid programs are the largest payers for our products, rules related to the programs’ coverage and reimbursement continue to represent an important issue for our business. New regulations related to hospital and physician payment continue to be implemented annually. In addition, regulations implemented as a result of the Deficit Reduction Act of 2005, the Medicare, Medicaid, and State Children’s Health Insurance Program Extension Act of 2007, and the Medicare Improvements for Patients and Providers Act of 2008 will continue to affect the reimbursement for our products paid by Medicare, Medicaid, and other public payers. We consider these rules as we plan our business and as we work to present our point of view to legislators and payers. |
| Ÿ | Intellectual property protection of our products is crucial to our business. Loss of effective intellectual property protection |
| Manufacturing |
| Our ability to attract and retain highly qualified and talented people in all areas of the company, and our ability to maintain our unique culture, particularly in light of the Roche Tender Offer or any other tender offer or other proposal by Roche to acquire all of the outstanding shares of our Common Stock not owned by Roche, will be critical to our success over the long-term. |
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| Ÿ | Since September 2008, the financial markets have experienced high volatility and significant price declines, and the availability of credit has decreased significantly, making it more difficult for businesses to access capital. Various macroeconomic factors impacted by the financial markets could affect our business and the results of our operations. Macroeconomic factors could affect the ability of patients to pay for co-pay costs. Interest rates and the ability to access credit markets could affect the ability of our customers/distributors to purchase, pay for, and effectively distribute our products. Similarly, these macroeconomic factors could also affect the ability of our sole-source or single-source suppliers to remain in business or otherwise supply product; failure by any of them to remain a going concern could affect our ability to manufacture products. In addition, if inflation or other factors were to significantly increase our business costs, it may not be feasible to pass significant price increases on to our customers due to the process by which physician reimbursement for our products is calculated by the government. |
Critical Accounting Policies and the Use of Estimates
The accompanying discussion and analysis of our financial condition and results of operations are based uponon our consolidated financial statementsConsolidated Financial Statements and the related disclosures, which have been prepared in accordance with U.S. generally accepted accounting principles generally accepted in the United States (or “GAAP”)(GAAP). The preparation of these consolidated financial statementsConsolidated Financial Statements requires management to make estimates, assumptions, and judgments that affect the reported amounts in our consolidated financial statementsConsolidated Financial Statements and accompanying notes. These estimates form the basis for making judgments about the carrying values of assets and liabilities. We base our estimates and judgments on historical experience and on various other assumptions that we believe to be reasonable under the circumstances, and we have established internal controls related to the preparation of these estimates. Actual results and the timing of the results could differ materially from these estimates.
We believe the following policies to be critical to understanding our financial condition, results of operations, and our expectations for 20062009, because these policies require management to make significant estimates, assumptions, and judgments about matters that are inherently uncertain.
Product Sales Allowances
Revenue from U.S. product sales is recorded net of allowances and accruals for rebates, healthcare provider contractual chargebacks, prompt-pay sales discounts, product returns, and wholesaler inventory management allowances, all of which are established at the time of sale. Sales allowances and accruals are based on estimates of the amounts earned or to be claimed on the related sales. The amounts reflected in our Consolidated Statements of Income as product sales allowances have been relatively consistent at approximately seven to eight percent of gross sales. In order to prepare our Consolidated Financial Statements, we are required to make estimates regarding the amounts earned or to be claimed on the related product sales.
Definitions for product sales allowance types are as follows:
| Ÿ | Rebate allowances and accruals include both direct and indirect rebates. Direct rebates are contractual price adjustments payable to direct customers, mainly to wholesalers and specialty pharmacies that purchase products directly from us. Indirect rebates are contractual price adjustments payable to healthcare providers and organizations such as clinics, hospitals, pharmacies, Medicaid, and group purchasing organizations that do not purchase products directly from us. |
| Ÿ | Product returns allowances are established in accordance with our Product Returns Policy. Our returns policy allows product returns within the period beginning two months prior to and six months following product expiration. |
| Ÿ | Prompt-pay sales discounts are credits granted to wholesalers for remitting payment on their purchases within established cash payment incentive periods. |
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| Ÿ | Wholesaler inventory management allowances are credits granted to wholesalers for compliance with various contractually defined inventory management programs. These programs were created to align purchases with underlying demand for our products and to maintain consistent inventory levels, typically at two to three weeks of sales depending on the product. |
| Ÿ | Healthcare provider contractual chargebacks are the result of our contractual commitments to provide products to healthcare providers at specified prices or discounts. |
We believe that our estimates related to wholesaler inventory management payments are not material amounts, based on the historical levels of credits and allowances as a percentage of product sales. We believe that our estimates related to healthcare provider contractual chargebacks and prompt-pay sales discounts do not have a high degree of estimation complexity or uncertainty, as the related amounts are settled within a short period of time. We consider rebate allowances and accruals and product returns allowances to be the only estimations that involve material amounts and require a higher degree of subjectivity and judgment to account for the obligations. As a result of the uncertainties involved in estimating rebate allowances and accruals and product returns allowances, there is a possibility that materially different amounts could be reported under different conditions or using different assumptions.
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All of the aforementioned categories of allowances and accruals are evaluated quarterly and adjusted when trends or significant events indicate that a change in estimate is appropriate. Such changes in estimate could materially affect our results of operations or financial position; however, to date they have not been material. It is possible that we may need to adjust our estimates in future periods. Our Consolidated Balance Sheets reflect estimated product sales allowance reserves and accruals totaling $234 million and $176 million as of December 31, 2008 and 2007, respectively.
Royalties
For many of our agreements with licensees, we estimate royalty revenue and royalty receivables in the period that the royalties are earned, which is in advance of collection. Royalties from Roche, which are approximately 60% of our total royalty revenue, are reported using actual sales reports from Roche. Our royalty revenue and receivables from non-Roche licensees are determined based on communication with some licensees, historical information, forecasted sales trends, and our assessment of collectibility. As all of these factors represent an estimation process, there is inherent uncertainty and variability in our recorded royalty revenue. Differences between actual royalty revenue and estimated royalty revenue are adjusted for in the period in which they become known, typically the following quarter. Since 2006, the changes in estimates for our royalty revenue related to prior periods arising from this estimation process has not exceeded 1% of total annual royalty revenue. To further illustrate our sensitivity to the royalty estimation process, a 1% adjustment to total annual royalty revenue, which is at the upper end of the range of our historic experience, would result in an adjustment to our annual royalty revenue of approximately $25 million (or approximately $0.01 to $0.02 per share, net of any related royalty expenses).
For cases in which the collectibility of a royalty amount is not reasonably assured, royalty revenue is not recorded in advance of payment but is recognized as cash is received. In the case of a receivable related to previously recognized royalty revenue that is subsequently determined to be uncollectible, the receivable is reserved for by reversing the previously recorded royalty revenue in the period in which the circumstances that make collectibility doubtful are determined, and future royalties from the licensee are recognized on a cash basis until it is determined that collectibility is reasonably assured.
Royalties include royalty revenue from confidential licensing agreements related to our patents, including the Cabilly patent. The Cabilly patent, which expires in December 2018, relates to methods that we and others use to make certain legal proceedingsantibodies or antibody fragments, as discussedwell as cells and DNA used in those methods. The Cabilly patent is the subject of litigation and a Patent Office reexamination proceeding. See also Note 7,9, “Leases, Commitments, and Contingencies,” in the Notes to Consolidated Financial Statements ofin Part II, Item 8 of this Form 10-K.10-K for more information on our Cabilly patent litigation and reexamination.
Cabilly patent royalties are generally due 60 days after the end of the quarter in which they are earned. During the fourth quarter of 2008, we changed our process of recognizing royalty revenue from a number of our Cabilly licensees from an accrual basis to a cash basis based on our assessment of collectibility. As a result of this change, royalty revenue decreased approximately $80 million in the fourth quarter of 2008 compared to the third quarter of 2008. As of December 31, 2008, our Consolidated Balance Sheet included no Cabilly patent royalty accounts receivable, reflecting the fact that now all of our Cabilly patent royalties are recorded on a cash basis.
Income Taxes
Our income tax provision is computed using the liability method in accordance with Statement of Financial Accounting Standards (FAS) No. 109, “Accounting for Income Taxes.” Deferred tax assets and liabilities are determined based on the difference between the financial statement and tax basis of assets and liabilities using tax rates projected to be in effect for the year in which the differences are expected to reverse. Significant estimates are required in determining our provision for income taxes. Some of these estimates are based on interpretations of existing tax laws or regulations, or the findings or expected results from any tax examinations. Various internal and external factors may have favorable or unfavorable effects on our future effective income tax rate. These factors include, but are not limited to, changes in tax laws, regulations, and/or rates; the results of any tax examinations;
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changing interpretations of existing tax laws or regulations; changes in estimates of prior years’ items; past and future levels of R&D spending; acquisitions; changes in our corporate structure; and changes in overall levels of income before taxes—all of which may result in periodic revisions to our effective income tax rate. Uncertain tax positions are accounted for in accordance with Financial Accounting Standards Board (FASB) Interpretation No. 48, “Accounting for Uncertainty in Income Taxes” (FIN 48). We accrue tax-related interest and penalties related to uncertain tax positions, and include these items with income tax expense in the Consolidated Statements of Income.
Loss Contingencies
We are currently, and have been, involved in certain legal proceedings, including licensing and contract disputes, stockholder lawsuits, and other matters. See Note 9, “Leases, Commitments, and Contingencies,” in the Notes to Consolidated Financial Statements in Part II, Item 8 of this Form 10-K for more information on these matters. We assess the likelihood of any adverse judgments or outcomes tofor these legal matters as well as potential ranges of probable losses. Included in “litigation-relatedWe record an estimated loss as a charge to income if we determine that, based on information available at the time, the loss is probable and other long-term liabilities” in the accompanying consolidated balance sheet at December 31, 2005 is $676.1 million, which represents our estimateamount of loss can be reasonably estimated. If only a range of the costs forprobable loss can be reasonably estimated, we accrue a liability at the current resolutionlow end of these matters.that range. The nature of these matters is highly uncertain and subject to change; as a result, the amount of our liability for certain of these matters could exceed or be less than the amount of our current estimates, depending on the final outcome of these matters. An outcome of such matters different than previously estimatedthat differs from our current estimates could have a material effect on our financial position or our results of operations in any one quarter.
Further, the valuation of inventory requires us to estimate the market value of inventory that may expire prior to use based on our estimates of future demand for our products. If inventory costs exceed expected market value due to obsolescence or lack of demand, reserves are recorded for the difference between the cost and estimated market or recoverable value. These reserves are determined based on significant estimates, particularly estimated future demand for our products. Future product demand estimates are based on management’s best estimates, after evaluating numerous market conditions and product factors, including expected market penetration rates, competitive products entrants, intellectual property matters, the reimbursement environment, pricing, our distribution strategy as well as those of our distribution partners, efficacy and safety data from current and future clinical studies, and finalized regulatory actions with respect to product labeling and usage guidelines, among other factors.
Between October 2, 2008 and February 10, 2009, we issued three Dear Healthcare Provider letters to inform physicians of three cases of PML reported in Raptiva-treated patients. On February 19, 2009, the EMEA announced its recommendation to suspend the marketing authorization held by our collaborator, Merck Serono, for Raptiva in the European Union. The EMEA’s announcement is not expected to result in an impairment of the value of our Raptiva inventory. Also on February 19, 2009, the FDA issued a public health advisory regarding Raptiva, which provided warnings about PML and the amounts earneduse of Raptiva, and advised physicians to periodically re-evaluate patients treated with Raptiva and to consider other approved therapies to control patients’ psoriasis. We are currently in discussions with the FDA regarding potential label changes and restrictions for the use of Raptiva that could potentially have a materially adverse effect on demand for the product in the U.S. Our discussions with the FDA have not been finalized and we cannot yet reliably estimate the effect of any resultant changes on future demand for Raptiva in the U.S. As of December 31, 2008, we held approximately $130 million of Raptiva work-in-process and finished goods inventory. If future FDA actions or other events or decisions lead to a substantial decrease in expected demand for Raptiva in the U.S., we could experience a material reduction in the market value of our Raptiva inventory and be claimedrequired to write-down a portion, or all, of that inventory. For example, if our current discussions with the FDA result in significant new regulatory requirements that affect how physicians prescribe Raptiva or other labeling restrictions that would individually or collectively reduce demand for and use of the product to a substantial extent, we believe that such actions would result in the vast majority of our Raptiva inventory value being impaired.
Employee Stock-Based Compensation
Under the provisions of FAS No. 123(R), “Share-Based Payment” (FAS 123R), employee stock-based compensation is estimated at the date of grant based on the related product sales.employee stock award’s fair value using the Black-Scholes option-pricing model and is recognized as
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expense ratably over the requisite service period in a manner similar to other forms of compensation paid to employees. The Black-Scholes option-pricing model requires the use of certain subjective assumptions. The most significant of these assumptions are our estimated obligations to wholesalers and third parties (clinics, hospitals and pharmacies), respectively. These rebates and accruals result from performance-based offers that are primarily based on attaining contractually specified sales volumes and growth. As a result, the calculationestimates of the accrual for these rebates requiresexpected volatility of the market price of our stock and the expected term of the award. Due to the redemption of our Special Common Stock in June 1999 (Redemption) by Roche Holdings, Inc. (RHI), there is limited historical information available to support our estimate of certain assumptions required to value our stock options as an option grant cycle lasts ten years. When establishing an estimate of the customer’sexpected term of an award, we consider the vesting period for the award, our recent historical experience of employee stock option exercises (including post-vesting forfeitures), the expected volatility, and a comparison to relevant peer group data. As required under GAAP, we review our valuation assumptions at each grant date, and, as a result, our valuation assumptions used to value employee stock-based awards granted in future periods may change. See Note 3, “Retention Plans and Employee Stock-Based Compensation,” in the Notes to Consolidated Financial Statements in Part II, Item 8 of this Form 10-K for more information.
Results of Operations
(In millions, except per share amounts)
Annual Percentage Change | ||||||||||||||||||||
2008 | 2007 | 2006 | 2008/2007 | 2007/2006 | ||||||||||||||||
| Product sales | $ | 10,531 | $ | 9,443 | $ | 7,640 | 12 | % | 24 | % | ||||||||||
| Royalties | 2,539 | 1,984 | 1,354 | 28 | 47 | |||||||||||||||
| Contract revenue | 348 | 297 | 290 | 17 | 2 | |||||||||||||||
| Total operating revenue | 13,418 | 11,724 | 9,284 | 14 | 26 | |||||||||||||||
| Cost of sales | 1,744 | 1,571 | 1,181 | 11 | 33 | |||||||||||||||
| Research and development | 2,800 | 2,446 | 1,773 | 14 | 38 | |||||||||||||||
| Marketing, general and administrative | 2,405 | 2,256 | 2,014 | 7 | 12 | |||||||||||||||
| Collaboration profit sharing | 1,228 | 1,080 | 1,005 | 14 | 7 | |||||||||||||||
| Write-off of in-process research and development related to acquisition | – | 77 | – | (100 | ) | – | ||||||||||||||
| Gain on acquisition | – | (121 | ) | – | (100 | ) | – | |||||||||||||
| Recurring amortization charges related to redemption and acquisition | 172 | 132 | 105 | 30 | 26 | |||||||||||||||
| Special items: litigation-related | (260 | ) | 54 | 54 | (581 | ) | 0 | |||||||||||||
| Total costs and expenses | 8,089 | 7,495 | 6,132 | 8 | 22 | |||||||||||||||
| Operating income | 5,329 | 4,229 | 3,152 | 26 | 34 | |||||||||||||||
| Other income (expense): | ||||||||||||||||||||
| Interest and other income, net | 184 | 273 | 325 | (33 | ) | (16 | ) | |||||||||||||
| Interest expense | (82 | ) | (76 | ) | (74 | ) | 8 | 3 | ||||||||||||
| Total other income, net | 102 | 197 | 251 | (48 | ) | (22 | ) | |||||||||||||
| Income before taxes | 5,431 | 4,426 | 3,403 | 23 | 30 | |||||||||||||||
| Income tax provision | 2,004 | 1,657 | 1,290 | 21 | 28 | |||||||||||||||
| Net income | $ | 3,427 | $ | 2,769 | $ | 2,113 | 24 | 31 | ||||||||||||
| Earnings per share: | ||||||||||||||||||||
| Basic | $ | 3.25 | $ | 2.63 | $ | 2.01 | 24 | 31 | ||||||||||||
| Diluted | $ | 3.21 | $ | 2.59 | $ | 1.97 | 24 | 31 | ||||||||||||
| Cost of sales as a % of product sales | 17 | % | 17 | % | 15 | % | ||||||||||||||
| Research and development as a % of total operating revenue | 21 | 21 | 19 | |||||||||||||||||
| Marketing, general and administrative as a % of total operating revenue | 18 | 19 | 22 | |||||||||||||||||
| Pretax operating margin | 40 | 36 | 34 | |||||||||||||||||
| Net income as a % of total operating revenue | 26 | 24 | 23 | |||||||||||||||||
| Effective income tax rate | 37 | 37 | 38 | |||||||||||||||||
________________________
Percentages in this table and throughout our discussion and analysis of financial condition and results of operations may reflect rounding adjustments.
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Total Operating Revenue
Total operating revenue increased 14% to $13,418 million in 2008 and increased 26% to $11,724 million in 2007. These increases were primarily due to higher product sales and royalty revenue, and are further discussed below.
Total Product Sales
(In millions)
Annual Percentage Change | ||||||||||||||||||||
| Product Sales | 2008 | 2007 | 2006 | 2008/2007 | 2007/2006 | |||||||||||||||
| Net U.S. product sales | ||||||||||||||||||||
| Avastin | $ | 2,686 | $ | 2,296 | $ | 1,746 | 17 | % | 32 | % | ||||||||||
| Rituxan | 2,587 | 2,285 | 2,071 | 13 | 10 | |||||||||||||||
| Herceptin | 1,382 | 1,287 | 1,234 | 7 | 4 | |||||||||||||||
| Lucentis | 875 | 815 | 380 | 7 | 114 | |||||||||||||||
| Xolair | 517 | 472 | 425 | 10 | 11 | |||||||||||||||
| Tarceva | 457 | 417 | 402 | 10 | 4 | |||||||||||||||
| Nutropin products | 358 | 371 | 378 | (4 | ) | (2 | ) | |||||||||||||
| Thrombolytics | 275 | 268 | 243 | 3 | 10 | |||||||||||||||
| Pulmozyme | 257 | 223 | 199 | 15 | 12 | |||||||||||||||
| Raptiva | 108 | 107 | 90 | 1 | 19 | |||||||||||||||
| Total net U.S. product sales | 9,503 | 8,540 | 7,169 | 11 | 19 | |||||||||||||||
| Net product sales to collaborators | 1,028 | 903 | 471 | 14 | 92 | |||||||||||||||
| Total net product sales | $ | 10,531 | $ | 9,443 | $ | 7,640 | 12 | 24 | ||||||||||||
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| The totals shown above may not appear to sum due to rounding. |
Total net product sales increased 12% to $10,531 million in 2008 and increased 24% to $9,443 million in 2007. Net U.S. sales increased 11% to $9,503 million in 2008 and increased 19% to $8,540 million in 2007. These increases in U.S. sales were due to higher sales across almost all products, in particular higher sales of our oncology products and sales resulting from the approval of Lucentis on June 30, 2006. Increased U.S. sales volume accounted for 74%, or approximately $710 million, of the increase in U.S. net product sales in 2008, and 83%, or approximately $1,100 million in 2007. Changes in net U.S. sales prices across the majority of products in the portfolio accounted for most of the remainder of the increases in U.S. net product sales in 2008 and 2007.
References below to market adoption and penetration, as well as patient share, are derived from our analyses of market tracking studies and surveys that we undertake with physicians. We consider these tracking studies and surveys indicative of trends and information with respect to the usage and buying patterns of the end-users of our products, and as indicative of the purchasing patterns of our wholesaler customers. We use statistical analyses and management judgment to interpret the data that we obtain, and as such, the adoption, penetration, and patient share data presented herein represent management’s best estimates. In general, we have rounded our percentage estimates to the nearest 5% due to inherent margins of error that exist due to limitations in sample size and the resulting applicable contractual rebate rate(s)timeliness in receiving and analyzing this data. We may modify our market study methodology in response to changes in the marketplace and how we manage the business. If we have such a change, we will provide comparative prior period data using the new methodology, if it is available.
Avastin
Net U.S. sales of Avastin increased 17% to $2,686 million in 2008 and 32% to $2,296 million in 2007. Net U.S. sales in 2008 excluded net revenue of $5 million that was deferred in connection with our Avastin Patient Assistance Program, and net U.S. sales in 2007 included the net recognition of $7 million of previously deferred revenue related to the program. The increase in sales in 2008 was primarily due to increased use of Avastin for first-line treatment of metastatic BC, which received accelerated approval from the FDA on February 22, 2008, as well as from increased use in metastatic NSCLC. The increase in sales in 2007 was primarily a result of increased use of Avastin in first-line metastatic NSCLC, and in metastatic BC, an unapproved use of Avastin during 2007.
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Among the approximately 50% to 60% of patients in first-line metastatic lung cancer who are eligible for Avastin therapy, we estimate that penetration in the fourth quarter of 2008 was approximately 65%, which is in-line with penetration throughout the year, but an increase relative to in the fourth quarter of 2007. Use of the standard dose, defined as at least 5 mg/kg/weekly-equivalent, during the fourth quarter of 2008 was approximately 75%, in-line with the third quarter of 2008. The labeled dose of Avastin in lung cancer is 15 mg/kg, administered intravenously every three weeks. On April 20, 2008, we announced an update to the previously reported Roche-sponsored international Phase III clinical study of Avastin (AVAiL) in combination with gemcitabine and cisplatin chemotherapy in patients with advanced, non-squamous, NSCLC. The update confirmed the statistically significant improvement in the primary endpoint of PFS for the two different doses of Avastin studied in the trial (15 mg/kg/every-three-weeks and 7.5 mg/kg/every-three-weeks) compared to chemotherapy alone. The study did not demonstrate a statistically significant prolongation of overall survival, a secondary endpoint, for either dose in combination with gemcitabine and cisplatin chemotherapy compared to chemotherapy alone. Median survival of patients in all arms of the study exceeded one year, longer than previously reported survival times in this indication.
In first-line metastatic BC patients, we estimate Avastin penetration in the fourth quarter of 2008 was approximately 40%, which is consistent with the prior quarter. With respect to dose, the percentage of metastatic BC patients receiving the standard dose of Avastin, defined as 5 mg/kg/weekly-equivalent, was in-line with that seen in previous quarters. The U.S. labeled dose of Avastin in metastatic BC is 10 mg/kg, administered intravenously every two weeks. On November 23, 2008, we announced that the RIBBON I study of Avastin in combination with taxane, anthracycline-based or capecitabine chemotherapies for first-line treatment of metastatic HER2-negative BC met its primary endpoint of increasing the time that patients lived without their disease advancing, compared to chemotherapies alone. Data from RIBBON I along with data from AVADO, the Roche-sponsored, placebo-controlled Phase III trial, which evaluated two dose levels of Avastin, a 7.5 mg/kg/every-three-weeks dose and a 15 mg/kg/every-three-week dose, in combination with docetaxel chemotherapy, will be submitted to the FDA by mid-2009, and are required for the FDA under the conditions of the accelerated approval we received on February 22, 2008. These data will be reviewed by the FDA and may affect the Avastin approval in BC.
In both first-line and second-line metastatic colorectal cancer (CRC), penetration in the fourth quarter of 2008 was in-line with the third quarter of 2008 and the fourth quarter of 2007.
On September 30, 2008, we announced that we submitted an sBLA to the FDA for Avastin as potential treatment for patients with advanced renal cell carcinoma.
On November 3, 2008, we announced that we submitted an sBLA to the FDA for Avastin as a potential treatment for patients with previously treated glioblastoma. If accepted by the FDA, the application would be considered for an accelerated approval that allows provisional approval of medicines for cancer or other life-threatening diseases based on preliminary evidence suggesting clinical benefit. We plan to initiate a global Phase III study in patients with newly diagnosed glioblastoma multiforme in the first half of 2009 that will evaluate Avastin with standard of care chemotherapy and radiation.
The NSABP is sponsoring an ongoing Phase III study (NSABP C-08) of Avastin plus chemotherapy in patients with early-stage colon cancer. During 2008, we announced that the NSABP informed us that the trial would continue, based on recommendations from an independent data monitoring committee after planned interim analyses and that the final efficacy and safety results were expected to be earnedavailable in 2009 rather than 2010 as was previously anticipated. We also announced that the interim analyses showed no new or unexpected safety events in the Avastin arm. On January 21, 2009, we announced that the NSABP informed us that the results of the study could be known and communicated as early as mid-April 2009. The exact timing of data availability will depend on the timing of disease progression events. If the required number of disease progression events as defined by the study’s statistical analytical plan has not occurred as of mid-April, then the NSABP will continue the study and we anticipate that the final results will most likely be known later in the second quarter of 2009.
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Rituxan
Net U.S. sales of Rituxan increased 13% to $2,587 million in 2008 and 10% to $2,285 million in 2007. Sales growth in 2008 and 2007 resulted from increased use of Rituxan in the oncology setting and in the RA setting, and from price increases in both years.
In the oncology setting, the increases were due to the use of Rituxan following chemotherapy in indolent NHL, including areas of unapproved use, and CLL, an unapproved use. We estimate that Rituxan’s overall adoption rate in the combined markets of NHL and CLL was approximately 85% for the fourth quarter of 2008, an increase compared to the fourth quarter of 2007.
Primary drivers of growth in the RA setting in 2008 were increased new patient starts and increased total numbers of prescribers to an estimated 80% of targeted rheumatologists. It remains difficult to precisely determine the sales split between Rituxan use in oncology and immunology settings since many treatment centers treat both types of patients, but we estimate that sales in the immunology setting represented approximately 11% to 13% of total Rituxan sales for 2008 compared to our revised estimate of approximately 8% to 10% of total Rituxan sales for 2007.
In January 2008, results from Rituxan Phase III SUNRISE trial met its primary endpoint. This study was a controlled retreatment study for patients with RA who have had an inadequate response to previous treatment with one or more tumor necrosis factor (TNF) antagonist therapies. A preliminary review of the safety data revealed no new safety signals.
On January 24, 2008 we announced that the SERENE Phase III clinical study of Rituxan in patients who have not been previously treated with a biologic met its primary endpoint of a significantly greater proportion of Rituxan-treated patients achieving an American College of Rheumatology (ACR) 20 response at week 24, compared to placebo. In this study, patients who received a single treatment course of two infusions of either 500 milligrams or 1,000 milligrams of Rituxan in combination with a stable dose of methotrexate displayed a statistically significant improvement in ACR20 scores compared to patients who received placebo in combination with methotrexate. Although the study was not designed to compare the Rituxan doses, treatment efficacy appears to be similar between both Rituxan doses.
On January 25, 2008, the FDA approved our sBLA to expand the label for Rituxan to include slowing the progression of structural damage in adult patients with moderate-to-severe RA who have failed TNF antagonist therapies.
On April 14, 2008, we and Biogen Idec announced that OLYMPUS, a Phase II/III study of Rituxan for PPMS, did not meet its primary endpoint as measured by the time to confirmed disease progression during the 96-week treatment period.
On April 29, 2008, we announced that the Phase II/III study of Rituxan for SLE did not meet its primary endpoint defined as the proportion of Rituxan treated patients who achieved a major clinical response or partial clinical response measured by British Isles Lupus Assessment Group, a lupus activity response index, compared to placebo at 52 weeks.
On October 6, 2008, we and Biogen Idec announced that a global Phase III study of Rituxan in combination with fludarabine and cyclophosphamide chemotherapy met its primary endpoint of improving PFS, as assessed by investigators, in patients with previously treated CD20-positive CLL compared to chemotherapy alone. There were no new or unexpected safety signals reported in the study. An independent review of the primary endpoint is being conducted for U.S. regulatory purposes. Earlier in 2008, Roche announced that another Phase III study of Rituxan, CLL-8, showed that a similar treatment combination improved PFS in patients with CLL who had not previously received treatment.
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On December 18, 2008, we announced that the IMAGE trial, a Phase III study in patients with early RA who have not been previously treated with methotrexate, met its primary endpoint. Patients in the study received two infusions of either 500 milligrams or 1,000 milligrams of Rituxan or placebo in combination of methotrexate. At 52 weeks, patients in the 1,000 milligrams treatment group met the primary endpoint of prevention of progression of structural damage. The safety data was consistent with previous studies and preliminary analysis did not reveal any new or unexpected safety signals.
Herceptin
Net U.S. sales of Herceptin increased 7% to $1,382 million in 2008 and 4% to $1,287 million in 2007. The sales growth in 2008 and 2007 was primarily due to price increases that occurred from 2006 through 2008, and increased use of Herceptin in the treatment of early-stage HER2-positive BC. We estimate that Herceptin’s penetration in the adjuvant setting was approximately 75% for the fourth quarter of 2008, which was in-line with the fourth quarter of 2007. In first-line HER2-positive metastatic BC patients, we estimate that Herceptin’s penetration was approximately 75% for the fourth quarter of 2008, which was also in-line with the fourth quarter of 2007.
On January 18, 2008, the FDA expanded the Herceptin label, based on the HERA study, for the treatment of patients with early-stage HER2-positive BC to include treatment for patients with node-negative BC.
On May 29, 2008, the FDA expanded the Herceptin label, based on the BCIRG 006 study, for the treatment of patients with early-stage HER2-positive BC to include Herceptin given with docetaxel and carboplatin. Herceptin also may now be administered for one year in an every-three-week dosing schedule, instead of weekly.
Lucentis
Lucentis was approved by the FDA for the treatment of neovascular (wet) age-related macular degeneration (AMD) on June 30, 2006. Net U.S. sales of Lucentis increased 7% to $875 million in 2008 and 114% to $815 million in 2007. The primary drivers of growth in 2008 were increased dosing and an improving market environment. Our most recent market research on dosing has shown an increase in the number of Lucentis injections in the patients’ first and second year of treatment. We believe that approximately 40% of newly diagnosed patients with wet AMD were treated with Lucentis during the fourth quarter of 2008, which remained broadly stable throughout 2008, and decreased from approximately 50% in the fourth quarter of 2007. We believe that key factors affecting Lucentis sales in 2008 and 2007 were the continued unapproved use of Avastin and reimbursement concerns from retinal specialists. Lucentis received a permanent J-code classification from the Centers for Medicare and Medicaid Services in January 2008, which we believe addressed some of the reimbursement concerns. The launch of improved patient access programs in March 2008, a revised promotional campaign, and enhanced distribution options for Lucentis that began in May 2008 also contributed to the sales growth in 2008. In October 2007 we announced that we planned to no longer allow compounding pharmacies the ability to purchase Avastin directly from wholesale distributors, and this change in distribution was made effective on January 1, 2008. However, physicians can purchase Avastin from authorized distributors and ship to the destination of the physicians’ choice.
Although sales increased in 2008, the AMD market remains challenging with the continued unapproved use of Avastin and reimbursement concerns of retinal specialists. We expect these factors to persist and limit Lucentis share growth.
In December, 2008, we issued a Dear Healthcare Provider letter to inform prescribing physicians that multiple cases of intraocular adverse events, including serious intraocular inflammatory reactions, following injection with Avastin had been reported in Canada. A single lot of Avastin which was distributed in Canada and 11 other countries outside the U.S. accounted for 25 of the 36 cases. We and Roche confirmed that the Avastin production lot had passed all quality inspections for its approved intravenous use in oncology.
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Xolair
Net U.S. sales of Xolair increased 10% to $517 million in 2008 and 11% to $472 million in 2007. Sales growth in 2008 and 2007 was driven by increased penetration in the asthma market and, to a lesser extent, price increases effective between 2006 and 2008. Increased sales in 2008 were consistent with our efforts to increase adoption of the National Heart, Lung, and Blood Institute asthma guidelines, which recommend that physicians consider Xolair as a standard part of therapy. At the FDA’s request, we and Novartis Pharma AG and affiliates (Novartis), our co-promotion collaborator, updated the Xolair product label in June 2007 with a boxed warning regarding the risk of anaphylaxis in patients receiving Xolair. As part of our continuing discussions with the FDA, on January 29, 2009, the FDA requested that we, as the BLA holder, submit a draft Risk Evaluation and Mitigation Strategy.
In the fourth quarter of 2008, we submitted an sBLA for Xolair to extend our current asthma indication to include children six years and older.
Tarceva
Net U.S. sales of Tarceva increased 10% to $457 million in 2008 and 4% to $417 million in 2007. The sales growth in 2008 was primarily due to price increases in 2008 and 2007 and slightly lower return reserve requirements compared to 2007. We estimate that Tarceva’s penetration in second-line NSCLC was approximately 25% for the fourth quarter of 2008, which was in-line with the fourth quarter of 2007. In the first-line pancreatic cancer setting, we estimate that Tarceva’s penetration was approximately 40% in 2008, which was also in-line compared to the fourth quarter of 2007.
Sales in 2007 were positively affected by price increases during 2007 and 2006. These increases, however, were partially offset by higher product returns and return reserve requirements in the second and third quarters of 2007 and by modest decreases in volume in 2007.
On October 5, 2008, we and OSI Pharmaceuticals announced that a randomized Phase III study (BeTa Lung) evaluating Avastin in combination with Tarceva in patients with advanced NSCLC whose disease had progressed following platinum-based chemotherapy did not meet its primary endpoint of improving overall survival compared to Tarceva in combination with a placebo. However, there was evidence of clinical activity with improvements in the secondary endpoints of PFS and response rate when Avastin was added to Tarceva compared to Tarceva alone. No new or unexpected safety signals for either Avastin or Tarceva were observed in the study, and adverse events were consistent with those observed in previous NSCLC clinical trials evaluating the agents.
On November 6, 2008, we and OSI Pharmaceuticals announced that a global Phase III study (SATURN) met its primary endpoint and showed Tarceva significantly extended the time patients with advanced NSCLC lived without their cancer getting worse when given immediately following initial treatment with platinum-based chemotherapy, compared to placebo. There were no new or unexpected safety signals in the study and adverse events were consistent with those observed in previous NSCLC clinical trials evaluating Tarceva. We and OSI Pharmaceuticals will discuss a potential U.S. filing based on SATURN with the FDA in 2009.
On February 2, 2009, we announced that a Phase III study (ATLAS) of Tarceva in combination with Avastin as maintenance therapy following initial treatment with Avastin plus chemotherapy in advanced NSCLC met its primary endpoint. The study was stopped early on the recommendation of an independent data safety monitoring board after a pre-planned interim analysis showed that combining Tarceva and Avastin significantly extended the time patients lived without their disease advancing, as defined by PFS, compared to Avastin plus placebo. A preliminary safety analysis showed that adverse events were consistent with previous Avastin or Tarceva studies, as well as trials evaluating the two medicines together, and no new safety signals were observed.
Nutropin Products
Combined net U.S. sales of our Nutropin products decreased 4% to $358 million in 2008 and decreased 2% to $371 million in 2007.
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Thrombolytics
Combined net U.S. sales of our three thrombolytics products—Activase, Cathflo Activase, and TNKase—increased 3% to $275 million in 2008 and 10% to $268 million in 2007.
Pulmozyme
Net U.S. sales of Pulmozyme increased 15% to $257 million in 2008 and 12% to $223 million in 2007.
Raptiva
Net U.S. sales of Raptiva increased 1% to $108 million in 2008 and increased 19% to $107 million in 2007.
On October 2, 2008, we announced that we issued a Dear Healthcare Provider letter to inform physicians of a case of PML in a 70-year-old patient who had received Raptiva for more than four years for treatment of chronic plaque psoriasis. The patient subsequently died. On October 16, 2008, revised prescribing information for Raptiva was approved by the FDA. A boxed warning was added that includes the recently reported case of PML and updated information on the risk of serious infections leading to hospitalizations and death in patients receiving Raptiva. The updated label also includes a warning about certain neurologic events as well as precautions regarding immunizations and pediatric use. A Dear Healthcare Provider letter was issued to communicate this updated prescribing information to physicians. On November 17, 2008, we announced that we issued a Dear Healthcare Provider letter to inform physicians of a second case of PML that resulted in the death of a 73-year old patient who had received Raptiva for approximately four years for treatment of chronic plaque psoriasis. On February 10, 2009, a Dear Healthcare Provider letter was sent to physicians to inform them of a third case of PML in a 47-year-old patient who had received Raptiva for more than three years for the treatment of chronic plaque psoriasis. On February 19, 2009, our collaborator, Merck Serono, and separately the EMEA, announced that the EMEA recommended the suspension of the marketing authorization for Raptiva from Merck Serono, and that the EMEA’s CHMP has concluded that the benefits of Raptiva no longer outweigh its risks because of safety concerns, including the occurrence of PML in patients taking the medicine. Also on February 19, 2009, the FDA issued a public health advisory regarding Raptiva, which provided warnings about PML and the use of Raptiva, and advised physicians to periodically re-evaluate patients treated with Raptiva and to consider other approved therapies to control patients’ psoriasis. We believe that Raptiva increases the risk of PML and that prolonged exposure to Raptiva or older age may further increase this risk. It is likely that this new safety information will affect usage patterns of Raptiva and we will likely see a reduction in demand in the future. We have submitted updated labeling to the FDA, and are working with the FDA to determine the appropriate next steps, which may include, among other things, significant restrictions in the use of or suspension or withdrawal of regulatory approval for Raptiva.
Sales to Collaborators
Product sales to collaborators, which were for non-U.S. markets, increased 14% to $1,028 million in 2008 and 92% to $903 million in 2007. The increase in 2008 was primarily due to increased sales of Avastin, Rituxan, and Herceptin to Roche. The increase in 2007 was primarily due to more favorable Herceptin pricing terms that were part of the supply agreement with Roche signed in the third quarter of 2006 and increased sales volume of Avastin and Herceptin. The favorable Roche Herceptin pricing terms concluded at the end of 2008.
For 2009, we expect sales to collaborators to decrease mainly due to lower volume and the conclusion of the favorable Roche Herceptin pricing terms, but the timing and amount of these sales can vary based on the production and order plan and other contractual issues.
Royalties
Royalty revenue increased 28% to $2,539 million in 2008 and 47% to $1,984 million in 2007. The increases were due to higher sales by Roche of Herceptin, Avastin, and Rituxan (which is marketed as MabThera® in most countries outside of the U.S.) in 2008 and 2007, and higher sales by various other licensees, including increased sales by Novartis of Lucentis. The increase in 2007 was also due to an acceleration of royalties during 2007, as discussed below. Approximately $115 million of the increase in 2008 was due to net foreign-exchange-related benefits from the weaker U.S. dollar during the year compared to 2007. Of the overall royalties recognized, royalty revenue from Roche represented 61% in 2008 and 2007 and 62% in 2006.
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In June 2007, we entered into a transaction with an existing licensee to license from it the right to co-develop and commercialize certain molecules. In exchange, we released the licensee from its obligation to make certain royalty payments to us that would have otherwise been owed between January 2007 and June 2010, and that period may be extended contingent upon certain events as defined in the agreement. We estimate that the fair value of the royalty revenue owed to us over the three-and-a-half-year period, less any amount recognized in the first quarter of 2007, was approximately $65 million, and this amount was recognized as royalty revenue in the second quarter of 2007. We also recognized a similar amount as R&D expense for the purchase of the new license, and thus the net earnings per share (EPS) effect of entering into this new collaboration was not significant in 2007.
Royalties include royalty revenue from confidential licensing agreements related to our patents, including the Cabilly patent. The Cabilly patent expires in December 2018, but is the subject of litigation and a Patent Office reexamination proceeding. During the fourth quarter of 2008, we changed our process of recognizing royalty revenue from a number of our Cabilly licensees from an accrual basis to a cash basis. As a result of this change, royalty revenue decreased approximately $80 million in the fourth quarter of 2008 compared to the third quarter of 2008. The contributions related to the Cabilly patent were as follows (in millions, except per share amounts):
2008 | 2007 | |||||||
| Royalty revenue | $ | 298 | $ | 256 | ||||
| COH’s share of royalty revenue | $ | 61 | $ | 50 | ||||
Net of tax effect of our Cabilly licensing agreements on diluted EPS(1) | $ | 0.14 | $ | 0.12 | ||||
______________________
| (1) | In addition, we record royalty expense in our COS for Cabilly-related payments to COH based on our U.S. product sales. Including the effect of these COS royalties, the net of tax effect of the Cabilly patent on diluted EPS was $0.09 and $0.08 in 2008 and 2007, respectively. |
See also Note 9, “Leases, Commitments, and Contingencies,” in the Notes to Consolidated Financial Statements in Part II, Item 8 of this Form 10-K for more information on our Cabilly patent reexamination and the Centocor, Inc. (a wholly-owned subsidiary of Johnson & Johnson) lawsuit related to the Cabilly patent.
Cash flows from royalty income include revenue denominated in foreign currencies. We currently enter into foreign currency option contracts (options) and forwards to hedge a portion of these foreign currency cash flows. These options and forwards are due to expire in 2009 and 2010. See also Note 2, “Summary of Significant Accounting Policies,” and Note 4, “Investment Securities and Financial Instruments—Derivative Financial Instruments,” in the Notes to Consolidated Financial Statements in Part II, Item 8 of this Form 10-K.
Royalties are difficult to forecast because of the number of products involved, ongoing licensing and intellectual property disputes, and the volatility of foreign currency exchange rates. In 2009, we have the particular uncertainties associated with recent U.S. dollar volatility and the unknown effect of the current macroeconomic environment on our licensees’ product sales. Roche’s royalty rate for Rituxan will decrease during 2009 in a number of countries that make up a significant portion of European sales, which will cause a reduction in our 2009 royalties in the range of $125 million to $150 million, offset by a corresponding decrease in our marketing, general and administrative (MG&A) expenses based on a decrease in the royalty expense that we will pay Biogen Idec.
Contract Revenue
Contract revenue increased 17% to $348 million in 2008, and increased 2% to $297 million in 2007. The increase in 2008 was mainly due to reimbursements from Roche related to R&D efforts, recognition of a portion of the previously deferred opt-in payment received from Roche related to our trastuzumab drug conjugate products, and new product opt-ins from Roche. Contract revenue in 2008 also included our share of European profits related to Xolair and manufacturing service payments related to Xolair, which Novartis pays us as a result of our acquisition of Tanox in 2007. However, these increases were partially offset by lower reimbursements from Roche related to R&D efforts on Avastin and the receipt of a milestone payment from Novartis in 2007 for European Union approval of
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Lucentis for the treatment of patients with AMD. Included in contract revenue in 2008 was $227 million of R&D expense reimbursements that were received from certain collaborators. Included in contract revenue in 2007 was $196 million of R&D expense reimbursements that were received from certain collaborators. The increase in 2007 was primarily due to the previously mentioned Lucentis milestone payment from Novartis, higher reimbursements from Biogen Idec related to R&D efforts on ocrelizumab, and recognition of previously deferred revenue from an opt-in payment from Roche on Rituxan. See “Related Party Transactions” below for more information on contract revenue from Roche.
Contract revenue varies each quarter and is dependent on a number of factors, including the timing and level of reimbursements from ongoing development efforts, milestone and opt-in payments received, changes in the relationships we have with our partners, and new contract arrangements.
Cost of Sales
Cost of sales (COS) as a percentage of net product sales was 17% in 2008 and 2007, and 15% in 2006. COS in 2008 included approximately $90 million in charges related to unexpected failed lots, delays from manufacturing start-up campaigns at one of our facilities, and excess capacity. COS in 2008 also included employee stock-based compensation expense of $82 million.
The increase in COS as a percentage of sales in 2007 was due to the recognition of employee stock-based compensation expense of $71 million, related to products sold for which employee stock-based compensation expense was previously capitalized as part of inventory costs in 2006, and a higher volume of lower margin sales to collaborators. COS in 2007 included a non-recurring charge of approximately $53 million, resulting from our decision to cancel and buy out a future manufacturing obligation. However, COS as a percentage of product sales in 2007 was favorably affected by increased U.S. sales of our higher margin products, primarily Avastin, Lucentis, Rituxan, and Herceptin, and the effects of a price increase on sales of Herceptin to Roche, which started in the third quarter of 2006 and concluded at the end of 2008.
Research and Development
Research and development (R&D) expenses increased 14% in 2008 and 38% in 2007 to $2,800 million and $2,446 million, respectively. R&D expense as a percentage of total operating revenue was 21% in 2008 and 2007, and 19% in 2006.
The increase in 2008 was primarily due to (i) increased development expenses, resulting from increased spending on clinical programs, mainly related to our GDC 0449 (Hedgehog Pathway Inhibitor) program, immunology programs, our drug conjugate products and other programs, including those related to collaboration arrangements entered into in 2007, and early-stage projects, (ii) expenses related to the retention plans approved by the Special Committee in 2008 of $66 million, and (iii) increased research costs, mainly due to increased internal personnel and related expenses. R&D expense in 2008 also included $105 million of in-licensing expense related to our new collaboration entered into with Roche and GlycArt for GA101.
The increase in 2007 was due to (i) increased development expenses resulting from increased activity across our entire product portfolio, increased spending on clinical programs, early stage projects and higher clinical manufacturing expenses in support of our clinical trials, (ii) increased research expenses, mainly due to increased internal personnel and related expenses, and (iii) increased in-licensing expense due to new collaborations with Abbott for the global research, development, and commercialization of two of Abbott’s investigational anti-cancer, small molecule compounds: ABT-263 and ABT-869; Seattle Genetics, Inc. for the development and commercialization of a humanized monoclonal antibody clinical trials for multiple myeloma, CLL, NHL, and diffuse large B-cell lymphoma; BioInvent to co-develop and commercialize a monoclonal antibody for the potential treatment of cardiovascular disease; and Altus related to a subcutaneously administered, once-per-week formulation of human growth hormone. The collaboration with Altus was terminated in 2007.
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Marketing, General and Administrative
Overall marketing, general and administrative (MG&A) expenses increased 7% to $2,405 million in 2008 and 12% to $2,256 million in 2007. MG&A as a percentage of total operating revenue was 18% in 2008, 19% in 2007 and 22% in 2006. The decline in this ratio primarily reflects the increase in operating revenue and our efforts to manage our infrastructure and support costs.
The increase in 2008 expense relative to 2007 was primarily due to: (i) expenses related to retention plans approved by the Special Committee of $69 million, (ii) an increase in royalty expense of $67 million, primarily to Biogen Idec resulting from higher sales of Rituxan by Roche, and (iii) legal and advisory fees incurred on behalf of the Special Committee and by the company in connection with the Roche Proposal. These increases were partially offset by lower property and equipment write-offs compared to 2007.
The increase in 2007 expense relative to 2006 was primarily due to: (i) an increase in royalty expense, primarily to Biogen Idec resulting from higher sales of Rituxan by Roche, (ii) increases resulting from ongoing marketing efforts with established products, primarily Herceptin, and newly launched products, including Rituxan for RA and Lucentis, (iii) increases in charitable contributions related to increased donations to independent public charities that provide co-pay assistance to eligible patients, (iv) an increase related to post-acquisition costs for Tanox, and (v) an increase related to property and equipment write-offs.
Collaboration Profit Sharing
Collaboration profit sharing expenses increased 14% to $1,228 million in 2008 and 7% to $1,080 million in 2007 primarily due to higher sales of Rituxan as well as higher U.S. sales of Tarceva and Xolair. The increase in 2007 was partially offset by a decrease in profit sharing expense related to Xolair operations outside the U.S.
The following table summarizes the amounts resulting from the respective profit sharing collaborations, for the periods presented (in millions):
Annual Percentage Change | ||||||||||||||||||||
2008 | 2007 | 2006 | 2008/2007 | 2007/2006 | ||||||||||||||||
| U.S. Rituxan profit sharing expense | $ | 848 | $ | 730 | $ | 672 | 16 | % | 9 | % | ||||||||||
| U.S. Tarceva profit sharing expense | 191 | 165 | 146 | 16 | 13 | |||||||||||||||
| Xolair profit sharing expense | 189 | 185 | 187 | 2 | (1 | ) | ||||||||||||||
| Total collaboration profit sharing expense | $ | 1,228 | $ | 1,080 | $ | 1,005 | 14 | 7 | ||||||||||||
We and Novartis share the U.S. and European operating profits for Xolair according to prescribed profit sharing percentages. Generally, we evaluate whether we are a net recipient or payer of funds on an annual basis in our cost and profit sharing arrangements. Net amounts received on an annual basis under such arrangements are classified as contract revenue, and net amounts paid on an annual basis are classified as collaboration profit sharing expense. With respect to the U.S. operating results, for the full years 2008, 2007 and 2006 we were a net payer to Novartis. As a result, for 2008, 2007, and 2006 the portion of the U.S. operating results that we owed to Novartis was recorded as collaboration profit sharing expense. With respect to the European operating results, for the full year of 2008, we were a net recipient from Novartis and for the full years in 2007 and 2006 we were a net payer to Novartis. As a result, for 2008, the portion of the European operating results that Novartis owed us was recorded as contract revenue. For the same periods in 2007 and 2006, however, our portion of the European operating results was recorded as collaboration profit sharing expense. Effective with our 2007 acquisition of Tanox, Novartis also makes additional profit sharing payments to us on U.S. sales of Xolair, which reduces our profit sharing expense.
Currently, our most significant collaboration profit sharing agreement is with Biogen Idec, with whom we co-promote Rituxan in the U.S. Under the collaboration agreement, Biogen Idec granted us a worldwide license to develop, commercialize, and market Rituxan in multiple indications. In exchange for these worldwide rights, Biogen Idec has co-promotion rights in the U.S. and a contractual period. Ifarrangement under which we share a portion of the pretax
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U.S. co-promotion profits of Rituxan, and we pay royalty expense based on sales of Rituxan by collaborators. In June 2003, we amended and restated the collaboration agreement with Biogen Idec to include the development and commercialization of one or more anti-CD20 antibodies targeting B-cell disorders, in addition to Rituxan, for a broad range of indications. In October 2008, Biogen Idec exercised their right under this agreement to opt in to our collaboration agreement with Roche and GlycArt for the joint development and commercialization of GA101.
Under the amended and restated collaboration agreement, our share of the current pretax U.S. co-promotion profit sharing formula is approximately 60% of operating profits, and Biogen Idec’s share is approximately 40% of operating profits. For each calendar year or portion thereof following the approval date of the first new anti-CD20 product, after a period of transition, our share of the pretax U.S. co-promotion profits will change to approximately 70% of operating profits, and Biogen Idec’s share will be approximately 30% of operating profits.
Collaboration profit sharing expense, exclusive of R&D expenses, related to Biogen Idec for the years ended December 31, 2008, 2007, and 2006, consisted of the following commercial activity (in millions):
Annual Percentage Change | ||||||||||||||||||||
2008 | 2007 | 2006 | 2008/2007 | 2007/2006 | ||||||||||||||||
| Product sales, net | $ | 2,587 | $ | 2,285 | $ | 2,071 | 13 | % | 10 | % | ||||||||||
| Combined commercial costs and expenses | 579 | 552 | 489 | 5 | 13 | |||||||||||||||
| Combined co-promotion profits | $ | 2,008 | $ | 1,733 | $ | 1,582 | 16 | 10 | ||||||||||||
| Amount due to Biogen Idec for their share of co-promotion profits–included in collaboration profit sharing expense | $ | 848 | $ | 730 | $ | 672 | 16 | 9 | ||||||||||||
In addition to Biogen Idec’s share of the combined co-promotion profits for Rituxan, collaboration profit sharing expense includes the quarterly settlement of Biogen Idec’s portion of the combined commercial costs. Since we and Biogen Idec each individually incur commercial costs related to Rituxan, and the spending mix between the parties can vary, collaboration profit sharing expense as a percentage of sales can also vary accordingly.
Total revenue and expenses related to our collaboration with Biogen Idec included the following (in millions):
Annual Percentage Change | ||||||||||||||||||||
2008 | 2007 | 2006 | 2008/2007 | 2007/2006 | ||||||||||||||||
| Contract revenue from Biogen Idec (R&D reimbursement) | $ | 122 | $ | 108 | $ | 79 | 13 | % | 37 | % | ||||||||||
| Co-promotion profit sharing expense | $ | 848 | $ | 730 | $ | 672 | 16 | 9 | ||||||||||||
| Royalty expense on sales of Rituxan outside the U.S. and other patent costs–included in MG&A expense | $ | 294 | $ | 247 | $ | 175 | 19 | 41 | ||||||||||||
Contract revenue from Biogen Idec primarily reflects the net reimbursement to us for development and post-marketing costs we incurred on joint development projects less amounts owed to Biogen Idec on their development efforts on these projects.
Write-off of In-process Research and Development Related to Acquisition
In connection with the acquisition of Tanox in the third quarter of 2007, we recorded a $77 million charge for in-process research and development. This charge primarily represents acquired R&D for label extensions for Xolair that have not yet been approved by the FDA and require significant further development. We expect to continue further developing these label extensions until a decision is made to file for a label extension or to discontinue development efforts. We expect these development efforts to be completed from 2009 to 2013, if they are not abandoned sooner.
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Gain on Acquisition
The acquisition of Tanox is considered to include the settlement of our 1996 license arrangement of certain intellectual property and rights thereon from Tanox. Under EITF 04-1, a business combination between parties with a preexisting relationship should be evaluated to determine if a settlement of that preexisting relationship exists. We measured the amount that the license arrangement is favorable, from our perspective, by comparing it to estimated pricing for current market transactions for intellectual property rights similar to Tanox’s intellectual property rights related to Xolair. In connection with the settlement of this license arrangement, we recorded a gain of $121 million on a pretax basis, in accordance with EITF 04-1.
Recurring Charges Related to Redemption and Acquisition
On June 30, 1999, RHI exercised its option to cause us to redeem all of our Special Common Stock held by stockholders other than RHI. The Redemption was reflected as the purchase of a business, which under GAAP required push-down accounting to reflect in our financial statements the amounts paid for our stock in excess of our net book value (see Note 1, “Description of Business—Redemption of Our Special Common Stock,” in the Notes to Consolidated Financial Statements in Part II, Item 8 of this Form 10-K).
In the third quarter of 2007, we acquired Tanox. In connection with the acquisition, we recorded approximately $814 million of intangible assets, representing developed product technology and core technology, which are being amortized over 12 years.
We recorded recurring charges related to the amortization of intangibles associated with the Redemption and push-down accounting and our 2007 acquisition of Tanox. These charges were $172 million in 2008, $132 million in 2007, and $105 million in 2006.
Special Items: Litigation-Related
The California Supreme Court heard our appeal on the COH matter on February 5, 2008, and on April 24, 2008 overturned the award of $200 million in punitive damages to COH but upheld the award of $300 million in compensatory damages. As a result of the California Supreme Court decision, we reversed a $300 million net litigation accrual related to the punitive damages and accrued interest, which we recorded as “Special items: litigation related” in our Consolidated Statements of Income for 2008. In 2007 and 2006, we recorded accrued interest and bond costs on both the compensatory and punitive damages totaling $54 million. We and COH have had discussions, but have not reached agreement, regarding additional royalties and other amounts owed by us to COH under the 1976 agreement for third-party product sales and settlement of a third-party patent litigation that occurred after the 2002 judgment. We recorded additional costs of $40 million in 2008 as “Special items: litigation-related” based on our estimate of a customer’s buying patterns is incorrect, we may need to adjust our estimatesrange of liability in future periods. In 2005,connection with the majorityresolution of these rebates relatedissues. See Note 9, “Leases, Commitments, and Contingencies,” in the Notes to Consolidated Financial Statements in Part II, Item 8 of this Form 10-K for further information regarding our non-oncology products.litigation.
Operating income increased 26% to our estimates$5,329 million in 2008 and increased 34% to $4,229 million in 2007. Our operating income as a percentage of product sales allowances that were material to our consolidated financial statements. However, it is possible that we may need to adjust our estimatesoperating revenue (pretax operating margin) was 40% in future periods. As of December 31, 2005, our consolidated balance sheet reflected product sales allowance reserves2008, 36% in 2007, and accruals34% in 2006.
Other Income (Expense)
Annual Percentage Change | ||||||||||||||||||||
2008 | 2007 | 2006 | 2008/2007 | 2007/2006 | ||||||||||||||||
| Gains on sales of biotechnology equity securities, net | $ | 109 | $ | 22 | $ | 93 | 395 | % | (76 | ) % | ||||||||||
| Write-downs of biotechnology debt and equity securities | (16 | ) | (20 | ) | (4 | ) | (20 | ) | 400 | |||||||||||
| Interest income | ||||||||||||||||||||
| Investment income | 157 | 300 | 230 | (48 | ) | 30 | ||||||||||||||
| Impairment charges | (67 | ) | (30 | ) | – | 123 | – | |||||||||||||
| Interest expense | (82 | ) | (76 | ) | (74 | ) | 8 | 3 | ||||||||||||
| Other miscellaneous income | 1 | 1 | 6 | 0 | (83 | ) | ||||||||||||||
| Total other income, net | $ | 102 | $ | 197 | $ | 251 | (48 | ) | (22 | ) | ||||||||||
For 2007, gains on sales of biotechnology equity securities, net, were lower compared to 2006, mainly due to 2006 gains on sales of approximately $79 million related to Amgen’s acquisition of Abgenix, Pfizer’s acquisition of Rinat, Stiefel Laboratories’ acquisition of Connetics Corporation, and AstraZeneca’s acquisition of Cambridge Antibody Technology. Investment income in 2007 was higher compared to 2006 due to higher average cash balances, partially offset by lower yields.
Income Tax Provision
The effective income tax expense is basedrate was 37% in 2008 and 2007, and 38% in 2006. The effective income tax rate in 2008 included a settlement with the Internal Revenue Services (IRS) for an item related to prior years. The effective income tax rate in 2007 was lower than in 2006, primarily due to the increase in the domestic manufacturing deduction.
We adopted the provisions of FIN 48 on income before taxes and is computed usingJanuary 1, 2007. Implementation of FIN 48 did not result in any adjustment to our Consolidated Statements of Income or a cumulative adjustment to retained earnings. As a result of the liability method. Deferredimplementation of FIN 48, we reclassified $147 million of unrecognized tax assets andbenefits from current liabilities are determined based on the difference between the financial statement and tax basis of assets and liabilities using enacted tax rates in effect for the year in which the differences are expected to reverse. Significant estimates are required in determining our provision for income taxes. Some of these estimates are based on interpretations of existing tax laws or regulations. long-term liabilities.
Various internal and external factors may have favorable or unfavorable effects on our future effective income tax rate. These factors include, but are not limited to, changes in tax laws, regulations and/or rates, the results of any tax examinations, changing interpretations of existing tax laws or regulations, changes in estimates of prior years’ items, future levels of R&D spending, and changes in overall levels of income before taxes. During 2005, we recorded various adjustments to our tax provision based on changes in one or more of the factors noted above.
Annual Percent Change | ||||||||||||||||
2005 | 2004 | 2003 | 2005/2004 | 2004/2003 | ||||||||||||
| Product sales | $ | 5,488.1 | $ | 3,748.9 | $ | 2,621.4 | 46 | % | 43 | % | ||||||
| Royalties | 935.1 | 641.1 | 500.9 | 46 | 28 | |||||||||||
| Contract revenue | 210.2 | 231.2 | 177.9 | (9 | ) | 30 | ||||||||||
| Total operating revenues | 6,633.4 | 4,621.2 | 3,300.2 | 44 | 40 | |||||||||||
| Cost of sales | 1,011.1 | 672.5 | 480.1 | �� | 50 | 40 | ||||||||||
| Research and development | 1,261.8 | 947.5 | 722.0 | 33 | 31 | |||||||||||
| Marketing, general and administrative | 1,435.0 | 1,088.2 | 794.8 | 32 | 37 | |||||||||||
| Collaboration profit sharing | 823.1 | 593.6 | 457.5 | 39 | 30 | |||||||||||
| Recurring charges related to redemption | 122.7 | 145.5 | 154.3 | (16 | ) | (6 | ) | |||||||||
| Special items: litigation-related | 57.8 | 37.1 | (113.1 | ) | 56 | * | ||||||||||
| Total costs and expenses | 4,711.5 | 3,484.4 | 2,495.6 | 35 | 40 | |||||||||||
| Operating income | 1,921.9 | 1,136.8 | 804.6 | 69 | 41 | |||||||||||
| Other income (expense): | ||||||||||||||||
| Interest and other income (expense), net | 140.9 | 90.0 | 95.7 | 57 | (6 | ) | ||||||||||
| Interest expense | (49.9 | ) | (7.4 | ) | (2.9 | ) | 574 | 155 | ||||||||
| Total other income, net | 91.0 | 82.6 | 92.8 | 10 | (11 | ) | ||||||||||
| Income before taxes and cumulative effect of accounting change | 2,012.9 | 1,219.4 | 897.4 | 65 | 36 | |||||||||||
| Income tax provision | 733.9 | 434.6 | 287.3 | 69 | 51 | |||||||||||
| Income before cumulative effect of accounting change | 1,279.0 | 784.8 | 610.1 | 63 | 29 | |||||||||||
| Cumulative effect of accounting change, net of tax | - | - | (47.6 | ) | - | * | ||||||||||
| Net income | $ | 1,279.0 | $ | 784.8 | $ | 562.5 | 63 | 40 | ||||||||
| Earnings per share: | ||||||||||||||||
| Basic: | ||||||||||||||||
| Earnings before cumulative effect of accounting change | $ | 1.21 | $ | 0.74 | $ | 0.59 | 64 | 25 | ||||||||
| Cumulative effect of accounting change, net of tax | - | - | (0.05 | ) | - | * | ||||||||||
| Net earnings per share | $ | 1.21 | $ | 0.74 | $ | 0.54 | 64 | 37 | ||||||||
| Diluted: | ||||||||||||||||
| Earnings before cumulative effect of accounting change | $ | 1.18 | $ | 0.73 | $ | 0.58 | 62 | 26 | ||||||||
| Cumulative effect of accounting change, net of tax | - | - | (0.05 | ) | - | * | ||||||||||
| Net earnings per share | $ | 1.18 | $ | 0.73 | $ | 0.53 | 62 | % | 38 | % | ||||||
| Pretax operating margin | 29 | % | 25 | % | 24 | % | ||||||||||
| COS as a % of product sales | 18 | 18 | 18 | |||||||||||||
| R&D as a % of operating revenues | 19 | 21 | 22 | |||||||||||||
| MG&A as a % of operating revenues | 22 | 24 | 24 | |||||||||||||
| NI as a % of operating revenues | 19 | 17 | 17 | |||||||||||||
Annual Percent Change | ||||||||||||||||
Product Sales | 2005 | 2004 | 2003 | 2005/2004 | 2004/2003 | |||||||||||
| Net U.S. Product Sales | ||||||||||||||||
| Rituxan | $ | 1,831.4 | $ | 1,574.0 | $ | 1,360.2 | 16 | % | 16 | % | ||||||
| Avastin | 1,132.9 | 544.6 | - | 108 | - | |||||||||||
| Herceptin | 747.2 | 479.0 | 406.0 | 56 | 18 | |||||||||||
| Tarceva | 274.9 | 13.3 | - | * | - | |||||||||||
| Xolair | 320.6 | 187.6 | 25.1 | 71 | 647 | |||||||||||
| Raptiva | 79.2 | 52.4 | 1.4 | 51 | * | |||||||||||
| Nutropin products | 370.5 | 348.8 | 319.5 | 6 | 9 | |||||||||||
| Thrombolytics | 218.5 | 194.4 | 181.7 | 12 | 7 | |||||||||||
| Pulmozyme | 186.5 | 157.1 | 143.7 | 19 | 9 | |||||||||||
| Total U.S. product sales | 5,161.7 | 3,551.2 | 2,437.6 | 45 | 46 | |||||||||||
| Net product sales to collaborators | 326.4 | 197.7 | 183.8 | 65 | 8 | |||||||||||
| Total product sales | $ | 5,488.1 | $ | 3,748.9 | $ | 2,621.4 | 46 | 43 | ||||||||
Annual Percent Change | ||||||||||||||||
Research and Development | 2005 | 2004 | 2003 | 2005/2004 | 2004/2003 | |||||||||||
| Product development | $ | 763.0 | $ | 540.7 | $ | 445.6 | 41 | % | 21 | % | ||||||
| Post-marketing | 172.2 | 127.5 | 81.0 | 35 | 57 | |||||||||||
| Total development | 935.2 | 668.2 | 526.6 | 40 | 27 | |||||||||||
| Research | 234.9 | 217.7 | 152.4 | 8 | 43 | |||||||||||
| In-licensing | 91.7 | 61.6 | 43.0 | 49 | 43 | |||||||||||
| Total | $ | 1,261.8 | $ | 947.5 | $ | 722.0 | 33 | 31 | ||||||||
Annual Percent Change | ||||||||||||||||
2005 | 2004 | 2003 | 2005/2004 | 2004/2003 | ||||||||||||
(in millions) | ||||||||||||||||
| Gains on sales of biotechnology equity securities and other | $ | 9.1 | $ | 11.9 | $ | 21.1 | (24 | )% | (44 | )% | ||||||
| Losses on biotechnology debt, equity securities and other | (10.1 | ) | (12.4 | ) | (3.8 | ) | (19 | ) | 226 | |||||||
| Interest income | 141.9 | 90.5 | 78.4 | 57 | 15 | |||||||||||
| Interest expense | (49.9 | ) | (7.4 | ) | (2.9 | ) | 574 | 155 | ||||||||
| Total other income, net | $ | 91.0 | $ | 82.6 | $ | 92.8 | 10 | (11 | ) | |||||||
Relationship with Roche
As a result of the June 1999 redemption of our Special Common Stock (“the Redemption”)Redemption and subsequent public offerings, we amended our certificate of incorporation and bylaws, amended our licensing and marketing agreement with F. Hoffmann-La Roche Ltd (or “Hoffmann-La Roche”)Holding AG and affiliates (Roche), an affiliate of Roche, and entered into or amended certain agreements with Roche,RHI, which are discussed below:below.
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Affiliation Arrangements
Our boardBoard of directorsDirectors consists of three RocheRHI directors, three independent directors nominated by a nominating committee currently controlled by Roche,RHI, and one Genentech employee. However, under our bylaws, RocheRHI has the right to obtain proportional representation on our boardBoard at any time. We believe Roche intends to continue to allow our current management to conduct our business and operations as we have done in the past. However, we cannot ensure that Roche will not implement a new business plan in the future.
Except as follows, the affiliation arrangements do not limit Roche’sRHI’s ability to buy or sell our Common Stock. If RocheRHI and its affiliates sell their majority ownership of shares of our Common Stock to a successor, RocheRHI has
agreed that it will cause the successor to agree to purchase all shares of our Common Stock not held by RocheRHI as follows:
| with consideration, if that consideration is composed entirely of either cash or equity traded on a U.S. national securities exchange, in the same form and amounts per share as received by |
| in all other cases, with consideration that has a value per share not less than the weighted-average value per share received by |
If RocheRHI owns more than 90% of our Common Stock for more than two months, RocheRHI has agreed that it will, as soon as reasonably practicable, effect a merger of Genentech with RocheRHI or an affiliate of Roche.RHI in compliance with the terms of the Affiliation Agreement.
| the merger or sale must be authorized by the favorable vote of a majority of |
| in the event such a favorable vote is not obtained, the value of the consideration to be received by |
| any acquisition, sale, or other disposal of all or a portion of our business representing 10% or more of our assets, net income, or |
| any issuance of capital stock except under certain circumstances; or |
| any repurchase or redemption of our capital stock other than a redemption required by the terms of any security and purchases made at fair market value in connection with any deferred compensation plans. |
Licensing Agreements Related to Genentech Products
We have a July 1999 amended and restated licensing and marketing agreement with Hoffmann-La Roche and its affiliates granting them an option to license, use, and sell our products in non-U.S. markets. The major provisions of that agreement include the following:
| Ÿ |
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| Ÿ | Roche’s options expire on October 25, 2015 except that Roche maintains: (1) a Phase II |
| Ÿ |
| Ÿ |
| Ÿ |
| Ÿ |
| Ÿ | For certain products for which Genentech is paying a royalty to Biogen Idec, including Rituxan, Roche shall pay Genentech a royalty of 20% on sales of such product in Roche’s licensed territory. Once Genentech is no longer obligated to pay a royalty to Biogen Idec on sales of such products in each country, Roche shall then pay Genentech a royalty on sales of 10% on the first $75 million on its aggregate sales of that product and thereafter a royalty of 8% on its aggregate sales of that product in excess of $75 million until the later in each country of the expiration of our last relevant patent or 25 years from the first commercial introduction of that product. During the fourth quarter of 2008, our obligation to pay a royalty to Biogen Idec on sales of Rituxan ended in certain countries. The shift from the 20% royalty on Rituxan to the lower 8% to 10% royalty rate will occur in certain countries during 2009 and beyond. |
We have further amended this licensing and marketing agreement with Hoffmann-La Roche to delete or add certain Genentech products under Hoffman-La Roche’s commercialization and marketing rights for Canada.
We also have a July 1998 licensing and marketing agreement relatingrelated to anti-HER2 antibodies (Herceptin(including Herceptin and Omnitarg)pertuzumab) with Hoffmann-La Roche, providing them with exclusive marketing rights outside of the U.S. Under the agreement, Hoffmann-La Roche funds one-half of the global development costs incurred in connection with developing new indicationsanti-HER2
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antibody products under the agreement. Either Genentech or Hoffmann-La Roche has the right to “opt-out” of developing an additional indication for a product and would not share the costs or benefits of the additional indication, but could “opt-back-in” beforewithin 30 days of the other party’s decision to file for approval of the indication by paying twice what would have been owed for development of the indication if no opt-out had occurred. Hoffmann-La Roche has also agreed to make royalty payments of 20% on aggregate net sales of a product sales outside the U.S. up to $500.0$500 million in each calendar year and 22.5% on such sales in excess of $500.0$500 million in each calendar year. In December 2007, Roche opted-in to our trastuzumab drug conjugate products under terms similar to those of the existing anti-HER2 agreement (see also “Related Party Transactions” below).
Licensing Agreements Related to Roche Products
We have entered into certain licensing agreements with Roche and its affiliates that grant us licenses to develop and commercialize products discovered by Roche and its affiliates.
In May 2008, Roche acquired Piramed Limited (Piramed), a privately held entity based in the United Kingdom. Prior to the Roche acquisition of Piramed, we had entered into a licensing agreement with Piramed related to molecules targeting the PI3 kinase pathway. As a result of Roche’s acquisition of Piramed, we now are party to this agreement with Roche and Piramed. Under the terms of the agreement Genentech could make future milestone and royalty payments to Roche. Roche retains the option to acquire rights to develop and commercialize certain products outside of the United States at the end of Phase II in exchange for an opt-in fee, royalties and a potential share of future development costs.
In June 2008, we entered into a licensing agreement with Roche under which we obtained rights to a preclinical small-molecule drug development program. The future R&D costs incurred under the agreement and any profit and loss from global commercialization are to be shared equally with Roche.
In September 2008, we entered into a collaboration agreement with Roche and GlycArt for the joint development and commercialization of GA101, a humanized anti-CD20 monoclonal antibody for the potential treatment of hematological malignancies and other oncology-related B-cell disorders such as NHL. The future global R&D costs incurred under the agreement are to be shared equally with Roche. We received commercialization rights in the U.S. and have the right to manufacture our own commercial requirements for the U.S. In October 2008, Biogen Idec exercised the right under our collaboration agreement with them to opt in to this agreement.
Research Collaboration Agreement
We have an April 2004 research collaboration agreement with Hoffmann-La Roche that outlines the process by which Hoffmann-La Roche and Genentech may agree to conduct and share in the costs of joint research on certain molecules, other than with regard to anti-HER2 antibodies as described above.molecules. The agreement further outlines how development and commercialization efforts will be coordinated with respect to select molecules, including the financial provisions for a number of different development and commercialization scenarios undertaken by either or both parties.
Manufacturing Agreements
We signed two product supply agreements with Roche in July 2006, each of which was amended in November 2007. The Umbrella Manufacturing Supply Agreement (Umbrella Agreement) supersedes our existing product supply agreements with Roche. The Short-Term Supply Agreement (Short-Term Agreement) supplements the terms of the Umbrella Agreement. Under the Short-Term Agreement, Roche has agreed to purchase specified amounts of Herceptin, Avastin and Rituxan through 2008. Under the Umbrella Agreement, Roche has agreed to purchase specified amounts of Herceptin and Avastin through 2012 and, on a perpetual basis, either party may order other collaboration products from the other party, including Herceptin and Avastin after 2012, pursuant to certain forecast terms. The Umbrella Agreement also provides that either party may terminate its obligation to purchase and/or supply Avastin and/or Herceptin with six years notice on or after December 31, 2007. To date, we have not provided to or received from Roche such notice of termination.
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In July 2008, we signed an agreement with Chugai Pharmaceutical Co., Ltd., a Japan-based entity and part of Roche, under which we agreed to manufacture Actemra, a product of Chugai, at our Vacaville, California facility. After an initial term of five years, the agreement may be terminated subject to certain terms and conditions under the contract.
Tax Sharing Agreement
We have a tax sharing agreement with Roche that pertainsRHI. If we and RHI elect to thefile a combined state and local tax returnsreturn in whichcertain states where we are consolidated or combined with Roche. We calculatemay be eligible, our tax liability or refund with RocheRHI for these state and localsuch jurisdictions as if we werewill be calculated on a stand-alone entity.basis.
We issue additional shares of Common Stock in connection with our stock option and stock purchase plans, and we may issue additional shares for other purposes. Our affiliation agreementAffiliation Agreement with RocheRHI provides, among other things, that we establish a stock repurchase program designedwith respect to maintain Roche’s percentage ownership interest inany issuance of our Common Stock. The affiliation agreement provides thatStock in the future, we will repurchase a sufficient number of shares pursuant to this programso that immediately after such that, with respect to any issuance, of Common Stock by Genentech in the future, the percentage of Genentechour Common Stock owned by Roche immediately after such issuanceRHI will be no lower than Roche’s lowest percentage ownership of Genentech Common Stock at any time after the offering of Common Stock occurring in July 1999 and prior to the time of such issuance, except that Genentech may issue shares up to an amount that would cause Roche’s lowest percentage ownership to be no more than 2% below the “Minimum Percentage.”Percentage” (subject to certain conditions). The Minimum Percentage equals the lowest number of shares of Genentech Common Stock owned by RocheRHI since the July 1999 offering (to be adjusted in the future for dispositions of shares of Genentech Common Stock by RocheRHI as well as for stock splits or stock combinations) divided by 1,018,388,704 (to be adjusted in the future for stock splits or stock combinations), which is the number of shares of Genentech Common Stock outstanding at the time of the July 1999 offering, as adjusted for the two-for-one splits of Genentech Common Stock in November 1999, October 2000 and May 2004.stock splits. We have repurchased shares of our Common Stock insince 2001 through 2005 (see discussion below in Liquidity“Liquidity and Capital Resources). As long as Roche’s percentage ownership is greater than 50%, prior to issuing any shares, the affiliation agreement provides that we will repurchase a sufficient number of shares of our Common Stock such that, immediately after our issuance of shares, Roche’s percentage ownership will be greater than 50%Resources”). The affiliation agreementAffiliation Agreement also provides that, upon Roche’sRHI’s request, we will repurchase shares of our Common Stock to increase Roche’sRHI’s ownership to the Minimum Percentage. In addition, RocheRHI will have a continuing option to buy stock from us at prevailing market prices to maintain its percentage ownership interest. Roche publicly offered zero-coupon notes in January 2000 which were exchangeable for Genentech Common Stock held by Roche. Roche called these notes in March 2004. Through April 5, 2004, the expiration date for investors to tender these notes, a total of 25,999,324 shares were issued in exchange for the notes, thereby reducing Roche’s ownership of Genentech Common Stock to 587,189,380 shares. At December 31, 2005, Roche’s ownership percentage was 55.7%. The Minimum Percentage at December 31, 2005 was 57.7% and, underUnder the terms of the affiliation agreement, Roche’sAffiliation Agreement, RHI’s Minimum Percentage is 57.7% and RHI’s ownership percentage is to be no lower than 55.7%. At December 31, 2008, RHI’s ownership percentage was 55.8%.
The Roche Proposal and the Roche Tender Offer
We announced on July 21, 2008 that we received the Roche Proposal and on July 24, 2008 we announced that the Special Committee was formed to review and consider the terms and conditions of the Roche Proposal, any business combination with Roche or any offer by Roche to acquire our securities, negotiate as appropriate, and, in the Special Committee’s discretion, recommend or not recommend the acceptance of the Roche Proposal by the minority shareholders. On August 13, 2008, we announced that the Special Committee had unanimously concluded that the Roche Proposal substantially undervalues the company, but that the Special Committee would consider a proposal that recognizes the value of the company and reflects the significant benefits that would accrue to Roche as a result of full ownership. On January 30, 2009, Roche announced that it intended to commence a tender offer which would replace the Roche Proposal that was announced on July 21, 2008. On January 30, 2009, in response to the announcement by Roche, the Special Committee urged shareholders to take no action with respect to the announcement by Roche and that the Special Committee will announce a formal position within 10 business days following the commencement of such a tender offer by Roche. On February 9, 2009, Roche commenced the Roche Tender Offer. The Roche Tender Offer is conditional upon, among other things, (i) a non-waivable condition that holders of at least a majority of the outstanding publicly-held Genentech shares tender their shares in the Roche Tender Offer and (ii) a condition, which may be waived by Roche in its sole discretion, that Roche has obtained sufficient financing to purchase all outstanding publicly-held Genentech shares and all Genentech shares issuable upon exercise of outstanding options and to pay related fees and expenses. The Roche Tender Offer includes other conditions as identified in Roche’s Schedule TO that was filed with the SEC on February 9, 2009. Also on February 9, 2009, the Special Committee urged shareholders to take no action with respect to the Roche Tender Offer. The Special Committee also announced that it intended to take a formal position within 10 business days of the commencement of the Roche Tender Offer, and will explain in detail its reasons for that position by filing a Statement on Schedule 14D-9 with the SEC.
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Roche Proposal-Related Costs
On August 18, 2008, we announced that the Special Committee adopted two retention plans that were implemented in lieu of our 2008 annual stock option grant and two severance plans that were adopted in addition to our existing severance plans. See Note 3, “Retention Plans and Employee Stock-Based Compensation,” in the Notes to Consolidated Financial Statements in Part II, Item 8 of this Form 10-K for more information on the retention plans. In addition, the Special Committee and the company have incurred and will continue to incur third-party legal and advisory costs in connection with the Roche Proposal and the Roche Tender Offer that are included in the “Marketing, general and administrative” expenses line of our Consolidated Statements of Income.
The cost of the retention plans adopted by the Special Committee on August 18, 2008 is estimated to be approximately $375 million payable in cash. The cash amount is approximately equal to the value of the stock options that would have been granted in our 2008 option grant program, calculated with the methodology used in our financial statements to value our options (Black-Scholes) and applying a discount rate. The discount rate reflects the earlier payment dates of the retention bonus relative to the vesting schedule that would have applied to the planned option grants. The timing of the payments related to these plans will depend on the outcome of the Roche Tender Offer or any other tender offer or other proposal by Roche to acquire all of the outstanding shares of our Common Stock not owned by Roche. If a merger of Genentech with Roche or an affiliate of Roche has not occurred on or before June 30, 2009, we will pay the retention bonus at that time, in accordance with the terms of the plans. We are currently recognizing the retention plan costs in our financial statements ratably over the period from August 18, 2008 to June 30, 2009. If a merger of Genentech with Roche or an affiliate of Roche has occurred on or before June 30, 2009, the timing of the payments and the recognition of the expense will depend upon the terms of the merger. During 2008, total costs for the retention plans were $162 million, of which $135 million was recognized as expense and $27 million was capitalized into inventory, which will be recognized as COS as products manufactured after the initiation of the retention plans are estimated to be sold.
In addition, the Special Committee and the company retained attorneys and third-party advisors in connection with the Roche Proposal and the Roche Tender Offer. The amount and timing of the payment of the third-party legal and advisory costs also depends on the resolution of matters relating to the Roche Proposal and the Roche Tender Offer. Third-party legal and advisory costs incurred in 2008 were $18 million.
The retention plan and third-party legal and advisory costs were as follows (in millions):
2008 | ||||
Retention plan costs(1) | ||||
| Research and development | $ | 66 | ||
| Marketing, general and administrative | 69 | |||
| Total retention plan costs | 135 | |||
| Third-party legal and advisory costs incurred by us on behalf of the Special Committee | 14 | |||
| Other third-party legal and advisory costs | 4 | |||
| Total retention plan costs and legal and advisory costs | 153 | |||
| Tax effect related to Roche Proposal-related costs | (60 | ) | ||
| Roche Proposal-related costs, net of tax | $ | 93 | ||
| Effect on earnings per share: | ||||
| Basic | $ | 0.09 | ||
| Diluted | $ | 0.09 | ||
_______________________
| (1) | In 2008, an additional $27 million of retention plan costs were capitalized into inventory, which will be recognized as COS as products that were manufactured after the initiation of the retention plans are estimated to be sold. |
Related Party Transactions
We enter into transactions with our related parties, Roche and other Roche affiliates (including Hoffmann-La Roche) and Novartis, under existing agreements in the ordinary course of business.Novartis. The accounting policies that we apply to our transactions with our related parties are consistent with those applied in transactions with independent third-partiesthird parties.
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In our royalty and supply arrangements with related parties, we believe that all related party agreements are negotiatedthe principal, as defined under EITF Issue No. 99-19, “Reporting Revenue Gross as a Principal versus Net as an Agent” (EITF 99-19), because we bear the manufacturing risk, general inventory risk, and the risk to defend our intellectual property. For circumstances in which we are the principal in the transaction, we record the transaction on an arm’s-lengtha gross basis in accordance with EITF 99-19. Otherwise, our transactions are recorded on a net basis.
Under the July 1999 amended and restated licensing and commercialization agreement, Roche has the right to opt in to development programs that we undertake on our products at certain pre-defined stages of development. Previously, Roche also had the right to develop certain products under the July 1998 licensing and commercialization agreement related to anti-HER2 antibodies (including Herceptin, pertuzumab, and trastuzumab-DM1). When Roche opts in to a program, we generally record the opt-in payments that we receive as deferred revenue, which we recognize over the expected development periods or product life, as appropriate. During 2008, we received approximately $110 million from Roche related to opt-ins to various programs, most of which was recorded as deferred revenue. As of December 31, 2008, the amounts in short-term and long-term deferred revenue related to opt-in payments received from Roche were $57 million and $214 million, respectively. In 2008, 2007, and 2006, we recognized $76 million, $40 million, and $27 million, respectively, as contract revenue related to opt-in payments previously received from Roche.
In February 2008, Roche acquired Ventana Medical Systems, Inc., and as a result of the acquisition, Ventana is considered a related party. We have engaged in transactions with Ventana prior to and since the acquisition.
In June 2003, Hoffmann-LaMay 2008, Roche exercised its optionacquired Piramed. Prior to license from us the rights to market Avastin for all countries outsideRoche acquisition of the U.S. under its existingPiramed, we had entered into a licensing agreement with us. AsPiramed related to molecules targeting the PI3 kinase pathway.
In June 2008, we entered into a licensing agreement with Roche under which we obtained rights to a preclinical small-molecule drug development program. We recorded $35 million in R&D expense in the second quarter of 2008 related to this agreement. The future R&D costs incurred under the agreement and any profit and loss from global commercialization will be shared equally with Roche.
In July 2008, we signed an agreement with Chugai Pharmaceutical Co., Ltd., a Japan-based entity and part of its opt-in, Hoffmann-La Roche, paid us approximately $188.0 million andunder which we agreed to pay 75%manufacture Actemra, a product of subsequent Avastin global development costs unless Hoffmann-LaChugai, at our Vacaville, California facility. After an initial term of five years, the agreement may be terminated subject to certain terms and conditions under the contract.
In August 2008, we entered into a Companion Diagnostics Master Agreement with Roche specifically opts out ofMolecular Systems (RMS) under which we have the development of certain other indications.We will receive royaltiesability to work with RMS to develop companion diagnostics based on net sales of Avastin in countries outside of the U.S. Hoffmann-La Roche received approval for Avastin in Israel in September 2004, in Switzerland in December 2004 and from the European Union in January 2005 for the treatment of patients with previously untreated metastatic cancer of the colon or rectum.RMS’ polymerase chain reaction platform technology.
In September 2003, Hoffmann-La2008, we entered into a collaboration agreement with Roche exercised its option to license from usand GlycArt for the rights to marketjoint development and commercialization of GA101, a humanized anti-CD20 monoclonal antibody that bindsfor the potential treatment of hematological malignancies and other oncology-related B-cell disorders such as NHL. We recorded $105 million in R&D expense in 2008 related to CD20,this collaboration. The future global R&D costs incurred under the agreement will be shared equally with Roche. We received commercialization rights in the U.S. and have the right to manufacture our own commercial requirements for all countries outsidethe U.S. In October 2008, Biogen Idec exercised the right under our collaboration agreement with them to opt in to this agreement and paid us an up-front fee of $32 million as part of the U.S. (other than territory previously committed to others) underopt-in, which we will recognize ratably as contract revenue over the existing licensing agreement. As part of its opt-in, Hoffmann-La Roche paid us $8.4 million and agreed to pay 50% of subsequent globalfuture development costs related to the humanized anti-CD20 antibody unless Roche opts out of the development of certain indications. We will receive royalties on the humanized anti-CD20 antibody in countries outside of the U.S.period.
We recognized royalty revenue based on 22.5% of net sales of Herceptin made by Hoffmann-La Roche outside of the U.S. exceeding $500.0 million in 2005 and 2004, and milestone-related royalty revenue of $20.0 million in 2003currently have no commercialized products subject to profit sharing arrangements with Roche.
2008 | 2007 | 2006 | ||||||||||
| Product sales to Roche | $ | 868 | $ | 768 | $ | 359 | ||||||
| Royalties earned from Roche | $ | 1,544 | $ | 1,206 | $ | 846 | ||||||
| Contract revenue from Roche | $ | 138 | $ | 95 | $ | 125 | ||||||
| Cost of sales on product sales to Roche | $ | 472 | $ | 422 | $ | 268 | ||||||
| R&D expenses incurred on joint development projects with Roche | $ | 336 | $ | 259 | $ | 213 | ||||||
| In-licensing expenses to Roche | $ | 145 | – | – | ||||||||
Novartis
We have an agreement with Novartis Ophthalmics (now merged intoPharma AG (a wholly-owned subsidiary of Novartis AG) under which Novartis OphthalmicsPharma AG has the exclusive right to develop and market Lucentis outside of the U.S. and Canada for indications related to diseases or disorders of the eye. As part of this agreement, in 2003, Novartis Ophthalmics paid an upfront milestone and R&D reimbursement fee of $46.6 million and the parties will share the cost of certain of our ongoing Phase III and related development expenses. We are not responsibleexpenses for any portion of the development and commercialization costs incurred by Novartis for the trials for which it is solely responsible outside of the U.S. and Canada, but we may receive additional payments for Novartis’ achievement of certain clinical development and product approval milestones outside of that region. In addition, we will receive royalties on net sales of Lucentis products, which we will manufacture and supply to Novartis, outside of the U.S. and Canada.Lucentis.
Under our existing arrangements with Novartis, we recognized the following amounts (in millions):
2008 | 2007 | 2006 | ||||||||||
| Product sales to Novartis | $ | 12 | $ | 10 | $ | 5 | ||||||
| Royalties earned from Novartis | $ | 241 | $ | 95 | $ | 3 | ||||||
| Contract revenue from Novartis | $ | 60 | $ | 70 | $ | 40 | ||||||
| Cost of sales on product sales to Novartis | $ | 9 | $ | 10 | $ | 4 | ||||||
| R&D expenses incurred on joint development projects with Novartis | $ | 43 | $ | 43 | $ | 38 | ||||||
| Collaboration profit sharing expense to Novartis | $ | 189 | $ | 185 | $ | 187 | ||||||
Contract revenue in 2007 included a $30 million milestone payment from Novartis for European Union approval of Lucentis for the treatment of neovascular (wet) AMD.
Certain R&D expenses are partially reimbursable to us by Novartis. The amounts that Novartis owes us, net of amounts reimbursable to Novartis by us on those projects, are recorded as contract revenue. Conversely, R&D expenses may include the net settlement of amounts we owe Novartis for R&D expenses that Novartis incurred on joint development projects, less amounts reimbursable to us by Novartis on these projects.
See Note 11, “Acquisition of Tanox, Inc.,” in Part II, Item 8 of this Form 10-K for information on Novartis’ share of the proceeds resulting from our acquisition of Tanox.
Financial Assets and Liabilities
On January 1, 2008, we adopted FAS No. 157, “Fair Value Measurements” (FAS 157), which established a framework for measuring fair value in GAAP and clarified the definition of fair value within that framework. FAS 157 also established a fair value hierarchy that prioritizes the use inputs used in valuation techniques into the following three levels:
Level 1—quoted prices in active markets for identical assets and liabilities
Level 2—observable inputs other than quoted prices in active markets for identical assets and liabilities
Level 3—unobservable inputs
A substantial majority of our financial instruments are Level 1 and Level 2 assets. As of December 31, 2008, the fair value of our Level 1 assets was $3.9 billion consisting primarily of cash, money market instruments, U.S. Treasury securities and marketable equity securities in biotechnology companies with which we have collaboration agreements. Included in this amount were gross unrecognized gains and losses of approximately $257 million and $1 million respectively, primarily related to marketable equity securities.
Our Level 2 assets include corporate bonds, commercial paper, government and agency securities, municipal bonds, asset-backed securities, preferred securities, and other derivatives. As of December 31, 2008, the fair value of our Level 2 assets was $5.6 billion, consisting primarily of corporate bonds, commercial paper, government and agency securities, municipal bonds and bonds denominated in foreign currencies but hedged to U.S. dollars. During 2008, we significantly reduced or eliminated our holdings in investments with a higher risk profile such as commodities, non-investment grade debt, preferred and asset-backed securities. Asset-backed securities and preferred securities represented about 1% of the total value of Level 2 assets as of December 31, 2008. Included in our Level 2 assets were gross unrecognized losses of approximately $45 million primarily related to corporate bonds offset by approximately $45 million of gross unrecognized gains primarily related to government-backed securities. In addition, the fair value of our Level 2 assets included approximately $45 million in gross unrecognized gains related to foreign currency derivative contracts that are held to hedge forecasted foreign-currency-denominated royalty
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revenue and interest rate swaps used to hedge interest rate movements that impact the fair value of our Senior Notes. In 2008, the U.S. Treasury announced actions that significantly reduced the value of U.S. government agency preferred securities, which we hold as investments. As a result, we recorded an impairment charge of $46 million during 2008.
As of December 31, 2008, our Level 3 assets consisted of student loan auction-rate securities and the preferred securities of an insolvent company. As of December 31, 2008, we held $145 million of investments, which were measured using unobservable (Level 3) inputs, representing about 2% of the total fair value of our investment portfolio. Student loan auction-rate securities of $145 million were valued based on broker-provided valuation models, which approximate fair value. In addition our Level 3 assets included preferred securities in a financial institution that declared bankruptcy during 2008. We recorded an impairment charge of $21 million during 2008 to fully impair these preferred securities, because we do not expect to recover the value of these assets during the bankruptcy proceedings. We also transferred the preferred securities to Level 3 assets from Level 2 assets.
The following table sets forth the fair value of our financial assets and liabilities reported on a recurring basis, including those pledged as collateral, or restricted (in millions).
December 31, 2008 | December 31, 2007 | |||||||||||||||
Assets | Liabilities | Assets | Liabilities | |||||||||||||
| Cash and cash equivalents | $ | 4,533 | $ | – | $ | 2,514 | $ | – | ||||||||
| Restricted cash | – | – | 788 | – | ||||||||||||
| Short-term investments | 1,665 | – | 1,461 | – | ||||||||||||
| Long-term marketable debt securities | 3,060 | – | 1,674 | – | ||||||||||||
| Total fixed income investment portfolio | 9,258 | – | 6,437 | – | ||||||||||||
| Long-term marketable equity securities | 287 | – | 416 | – | ||||||||||||
| Total derivative financial instruments | 83 | 31 | 30 | 19 | ||||||||||||
| Total | $ | 9,628 | $ | 31 | $ | 6,883 | $ | 19 | ||||||||
Liquidity and Capital Resources
Liquidity and Capital Resources | 2005 | 2004 | 2003 | |||||||
| December 31: | (in millions) | |||||||||
| Unrestricted cash, cash equivalents, short-term investments and long-term marketable debt and equity securities | $ | 3,813.9 | $ | 2,780.4 | $ | 2,934.7 | ||||
| Net receivable — equity hedge instruments | 73.3 | 21.3 | 121.9 | |||||||
| Total unrestricted cash, cash equivalents, short-term investments, long-term marketable debt and equity securities, and equity hedge instruments | $ | 3,887.2 | $ | 2,801.7 | $ | 3,056.6 | ||||
| Working capital | $ | 2,758.9 | $ | 2,187.3 | $ | 1,888.8 | ||||
| Current ratio | 2.7:1 | 2.8:1 | 3.2:1 | |||||||
Year Ended December 31: | ||||||||||
| Cash provided by (used in): | ||||||||||
| Operating activities | $ | 2,363.9 | $ | 1,194.8 | $ | 1,242.1 | ||||
| Investing activities | (1,776.1 | ) | (450.5 | ) | (1,403.6 | ) | ||||
| Financing activities | 367.5 | (846.3 | ) | 325.5 | ||||||
| Capital expenditures (included in investing activities above) | (1,399.8 | ) | (649.9 | ) | (322.0 | ) | ||||
| (In millions) | 2008 | 2007 | 2006 | |||||||||
| December 31: | ||||||||||||
| Unrestricted cash, cash equivalents, short-term investments and long-term marketable debt and equity securities | $ | 9,545 | $ | 6,065 | $ | 4,325 | ||||||
| Net receivable—equity hedge instruments | 40 | 24 | 50 | |||||||||
| Total unrestricted cash, cash equivalents, short-term investments, long-term marketable debt and equity securities, and equity hedge instruments | $ | 9,585 | $ | 6,089 | $ | 4,375 | ||||||
| Working capital | $ | 6,978 | $ | 4,835 | $ | 3,547 | ||||||
| Current ratio | 3.3:1 | 2.2:1 | 2.6:1 | |||||||||
| Year ended December 31: | ||||||||||||
| Cash provided by (used in): | ||||||||||||
| Operating activities | $ | 3,955 | $ | 3,230 | $ | 2,138 | ||||||
| Investing activities | (1,667 | ) | (1,865 | ) | (1,681 | ) | ||||||
| Financing activities | (269 | ) | (101 | ) | (432 | ) | ||||||
| Capital expenditures (included in investing activities above) | (751 | ) | (977 | ) | (1,214 | ) | ||||||
Total unrestricted cash, cash equivalents, short-term investments, and long-term marketable securities, including the estimated fair value of the related equity hedge instruments, were approximately $3.9$9.6 billion at December 31, 2005,2008, an increase of approximately $1.1$3.5 billion, or 39%57%, from December 31, 2004.2007. This increase primarily reflects cash generated from operations, increases from stock option exercises, and proceeds from our July 2005 debt issuance;the release of restricted cash and investments as a result of the COH litigation settlement; partially offset by repurchasescash used for the repurchase of our Common Stock, cash used for capital expenditures, including repaymentthe COH litigation settlement payment, and a financing payment related to the construction of our lease commitment, purchases of marketable securities, and repayment of our long-term debt and noncontrolling interest obligation under a synthetic lease.manufacturing facility in
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Singapore. To mitigate the risk of market value fluctuations, certainone of our biotechnology equity securities areis hedged with zero-cost collars and forward contracts, which are carried at estimated fair value. See Note 2, “Summary of Significant Accounting Policies — Policies—Comprehensive Income,” in the Notes to the Consolidated Financial Statements ofin Part II, Item 8 of this Form 10-K for further information regarding activity in our marketable investment portfolio and derivative instruments.
Cash Provided by Operating Activities
Cash provided by operating activities is primarily driven by increases in our net income. However, operating cash flows differ from net income as a result of non-cash charges or differences in the timing of cash flows and earnings recognition. Significant components of cash provided by operating activities are as follows:
Inventories decreased $209 million in 2008, as more products were sold than produced during the year. The decrease in inventories was due in part to failed lots and delays in start-up campaigns that we experienced during 2008.
Receivables and other assets increased $132 million in 2008. Accounts receivable—product sales” was $554.5sales increased $192 million at December 31, 2005, a decreaseprimarily due to timing of $44.6 million from December 31, 2004.sales to Roche in the fourth quarter of 2008. The average collection period of our “accounts receivable — accounts receivable—product sales”sales as measured in days sales outstanding (or “DSO”)(DSO) was 3736 days as of December 31, 2005, 582008, 33 days as of December 31, 2004,2007, and
Cash Used in Investing Activities
Cash used in investing activities was primarily relatedue to purchases, sales and maturities of investments and capital expenditures. Capital expenditures were $1.4$751 million during 2008, excluding the $200 million construction financing payment made during the year, compared to $1.0 billion during 2005 compared2007 and $1.2 billion during 2006. During 2008, capital expenditures were related to $649.9 million during 2004construction of our fill/finish facility in Hillsboro, Oregon, our E. coli production facility in Singapore, our second manufacturing facility in Vacaville, California, and $322.0 million during 2003. Capitalour research support facility in Dixon, California; leasehold improvements for newly constructed buildings on our South San Francisco, California campus; and purchases of equipment and information systems. During 2007, capital expenditures in 2005 included the purchase of the Oceanside plant for $408.1 million in cash plus $9.3 million in closing costs, $291.0 million inwere related to ongoing construction of our second manufacturing facility in Vacaville, California, $160.0 million repayment ofleasehold improvements for newly constructed buildings on our synthetic lease obligation on a research facility in South San Francisco California,campus, construction of our fill/finish facility in Hillsboro, and purchases of equipment and information systems. In addition, we acquired Tanox during 2007, for $833 million, net,
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which represents the purchase price of $925 million, plus $8 million in transaction costs, less approximately $100 million of Tanox’s cash and cash equivalents that we acquired. Capital expenditures in 2006 included ongoing construction for the Vacaville facility; validation costs at our manufacturing facility in Oceanside, California; the purchase of land,a second facility in Oceanside; the purchase of equipment and information systems,systems; and ongoing construction costs inexpenditures to support of our manufacturing and corporate infrastructure needs. We expect to incur additional capital costs at the Oceanside plant over the next 15 months, primarily for modifications and start-up and validation costs.
We anticipate that the amount of our 2009 capital expenditures for 2006 will be approximately $1.5billion, primarily driven by manufacturing expansion, in particular ramp-up of our ongoing construction of our second manufacturing facility in Vacaville, and for projects related to existing facilities, increases in office space, and land purchases.$600 million.
Cash Provided by or Used in Financing Activities
Cash provided by or used in financing activities is also related toincludes activity under our stock repurchase program andprogram. our employee stock plans.plans, our commercial paper program, and construction financing payments. We used cash for stock repurchases of $2.0 billion during 2005, $1.35 billion during 2004 and $201.3received $680 million in 2003 pursuant to our stock repurchase program approved by our Board of Directors. We
In 2007, we issued $600 million in unsecured commercial paper notes payable for funding general corporate purposes. In September 2008, we stopped issuing commercial paper due to cash requirements for capital expenditures, share repurchases under our stock repurchasethe state of the credit markets at that time and the resulting increase in the interest rates at which we sold commercial paper. We fully paid the remaining commercial paper notes payable by October 2008. In December 2008, in response to favorable changes in the credit markets, we recommenced this funding program and other usesissued $500 million of working capital. We believe our existing unrestricted funds, together with funds provided by operations and our debt issuance in July 2005 will be sufficient to meet our foreseeable future operating cash requirements. Our adoption of FAS 123R on January 1, 2006 is not expected to affect our cash position because the related transactions are non-cash in nature. See “Our affiliation agreement with Roche Holdings, Inc. could adversely affect our cash position” above in Part I, Item 1A “Risk Factors” of this Form 10-K for factors that could negatively affect our cash position.commercial paper notes payable.
Under a stock repurchase program approved by our Board of Directors in December 2003 and most recently extended in September 2004 and June 2005,April 2008, we are authorized to repurchase up to 80,000,000150 million shares of our Common Stock for an aggregate priceamount of up to $4.0$10.0 billion through June 30, 2006.2009. In this program, as in previous stock repurchase programs, purchases may be made in the open market or in privately negotiated transactions from time to time at management’s discretion. We also may engage in transactions in other Genentech securities in conjunction with the repurchase program, including certain derivative securities. Assecurities, although as of December 31, 2005,2008, we havehad not engaged in any such transactions. We intend to use the repurchased stock to offset dilution caused by the issuance of shares in connection with our employee stock plans.purchase plan. However, significant option exercises and stock purchases by employees could result in further dilution, and limitations in our ability to enter into new share repurchase arrangements could negatively affect our ability to offset dilution. Although there are currently no specific plans for the shares that may be purchased under the program, our goals for the program are (i)are: (1) to address provisions of our Affiliation Agreement with RHI related to maintaining RHI’s minimum ownership percentage, (2) to make prudent investments of our cash resources; (ii)resources, and (3) to allow for an effective mechanism to provide stock for our employee stock plans; and (iii) to address provisions of our affiliation agreement with Roche relating to maintaining Roche’s minimum ownership percentage.purchase plans. See above in “Relationship with Roche” above for more information on Roche’sRHI’s minimum ownership percentage. Under a previous stock repurchase program approved by our Board of Directors, we were authorized to repurchase up to $1.0 billion of our Common Stock through the period ended June 30, 2003.
We have enteredenter into Rule 10b5-1 trading plans to repurchase shares in the open market during those periods each quarter when trading in our stock is restricted under our insider trading policy. The trading plans cover approximately 2.3
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Under our current stock repurchase program, we repurchased nine million shares for $780 million in 2008. In addition, in November 2007, we entered into a prepaid share repurchase arrangement with an investment bank pursuant to which we delivered $300 million to the investment bank. The prepaid amount was reflected as a reduction of our stockholders’ equity as of December 31, 2007. There was no effect on EPS for the year ended December 31, 2007 as a result of entering into this arrangement. Under this arrangement, the investment bank delivered approximately four million shares to us on March 31, 2008. Under the stock repurchase program we repurchased 13 million shares for $1.0 billion in 2007, and the current plan is effective through June 30,12 million shares for $1.0 billion in 2006.
TOTAL | 2005 | 2004 | 2003 | 2002 and prior | |||||||||||||||||||||||||||
Shares | Amounts | Shares | Amounts | Shares | Amounts | Shares | Amounts | Shares | Amounts | ||||||||||||||||||||||
| Repurchase program expired June 30, 2003 | 47.6 | $ | 893.7 | - | $ | - | - | $ | - | 10.9 | $ | 195.3 | 36.7 | $ | 698.4 | ||||||||||||||||
| Repurchase program expiring June 30, 2006 | 49.8 | 3,373.6 | 24.1 | 2,015.9 | 25.6 | 1,351.7 | 0.1 | 6.0 | - | - | |||||||||||||||||||||
| Total repurchases | 97.4 | $ | 4,267.3 | 24.1 | $ | 2,015.9 | 25.6 | $ | 1,351.7 | 11.0 | $ | 201.3 | 36.7 | $ | 698.4 | ||||||||||||||||
Our shares repurchased during 2005the following months of 2008 were as follows (shares in millions):
Total Number of Shares Purchased in 2005 | Average Price Paid per Share | Total Number of Shares Purchased as Part of Publicly Announced Plans or Programs | Maximum Number of Shares that May Yet Be Purchased Under the Plans or Programs | ||||||||||
| January 1-31, 2005 | 1.4 | $ | 49.01 | ||||||||||
| February 1-28, 2005 | 1.3 | 47.16 | |||||||||||
| March 1-31, 2005 | 0.5 | 48.94 | |||||||||||
| April 1-30, 2005 | 0.1 | 56.86 | |||||||||||
| July 1-31, 2005 | 1.3 | 88.61 | |||||||||||
| August 1-31, 2005 | 9.2 | 88.63 | |||||||||||
| October 1 - 31, 2005 | 5.1 | 85.00 | |||||||||||
| November 1 - 30, 2005 | 4.6 | 94.37 | |||||||||||
| December 1 - 31, 2005 | 0.6 | 95.71 | |||||||||||
| Total | 24.1 | $ | 83.62 | 49.8 | 30.2 | ||||||||
Total Number of Shares Purchased | Average Price Paid per Share | |||||||
| March 1–31 | 4.2 | $ | 72.00 | |||||
| April 1–30 | 0.9 | 74.76 | ||||||
| May 1–31 | 1.5 | 68.77 | ||||||
| June 1–30 | 1.2 | 73.68 | ||||||
| September 1–30 | 5.5 | 90.24 | ||||||
| October 1–31 | 0.3 | 80.80 | ||||||
| Total | 13.6 | $ | 79.62 | |||||
As of December 31, 2008, 89 million shares have been purchased under our stock repurchase program for $6.5 billion, and a maximum of 61 million additional shares for amounts totaling up to $3.5 billion may be purchased under the program through June 30, 2009.
The par value method of accounting is used for Common Stockcommon stock repurchases. The excess of the cost of shares acquired over the par value is allocated to additional paid-in capital based on anwith the amounts in excess of the estimated averageoriginal sales price per issued share with the excess amounts charged to accumulated deficit.retained earnings (accumulated deficit).
We have certain contractual arrangements that create potential risk for us and are not recognized in our Consolidated Balance Sheets. Discussed below are off-balance sheet arrangements that have or are reasonably likely to have a material current or future effect on our financial condition, changes in financial condition, revenue or expenses, results of operations, liquidity, capital expenditures, or capital resources.
We lease various real properties under operating leases that generally require us to pay taxes, insurance, maintenance, and minimum lease payments. Some of our leases have options to renew.
In December 2004,October 2007, we entered into a Master Leasefive-year, $1 billion revolving credit facility with various financial institutions. The credit facility is expected to be used for general corporate and working capital purposes, including providing support for our commercial paper program. Of the $1 billion commitment, $50 million was committed by an institution that is currently undergoing bankruptcy proceedings, and therefore we do not expect to rely on this portion of the commitment. As of December 31, 2008, we did not have any borrowings under the credit facility.
Our Affiliation Agreement with Slough SSF, LLC forRHI provides, among other things, that with respect to any issuance of our Common Stock in the leasefuture, we will repurchase a sufficient number of property adjacent toshares so that immediately after such issuance, the percentage of our South San Francisco campus. The propertyCommon Stock owned by RHI will be developedno lower than 2% below the Minimum Percentage (subject to certain conditions). See “RHI’s Ability to Maintain Percentage Ownership Interest in Our Stock” in “Related Party” transactions for further discussion of our obligation to maintain RHI’s Minimum Percentage.
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In November 2006, we entered into eight buildings and two parking structures. The leasea series of the property will take place in two phases pursuantagreements with Lonza Group Ltd, including a supply agreement to separate lease agreements for each building as contemplatedpurchase product produced by the Master Lease Agreement. Phase I building leases will begin throughout 2006 and Phase II building leases will begin in 2007 and continue through 2008.Lonza at their Singapore manufacturing facility, which is currently under construction. For accounting purposes, due to the nature of the supply agreement and our involvement with the construction of the buildings, subject to the Master Lease Agreement, we are considered to be the owner of the assets during the construction period, through the lease commencement date, even though the funds to construct the building shell and some infrastructure costs are paid by the lessor.Lonza. As such, through the end of 2005,during 2008 and 2007, we have capitalized $93.6$107 million of construction costsand $141 million, respectively, in property, plant and equipment,construction-in-progress and have also recognized a corresponding amount as a construction financing obligation in “long-term“Long-term debt” in the accompanying consolidated balance sheets.Consolidated Balance Sheets. We expect atalso entered into a loan agreement with Lonza to advance $290 million to Lonza for the timeconstruction of this facility and $9 million for a related land lease option. In November 2008, the facility reached mechanical completion, ofand we advanced Lonza $200 million pursuant to the project, if all the buildings and infrastructure were completed by the lessor, our construction asset and related obligation will be in excess of $365.0 million, excluding costs related to leasehold improvements. Our aggregate lease payments as contemplated by the Master Lease Agreement through 2020 will be approximately $543.7 million.
loan agreement. See Note 7,9, “Leases, Commitments, and Contingencies,” in the Notes to Consolidated Financial Statements in Part II, Item 8 of this Form 10-K for further discussion of the agreements.
See also Note 9, “Leases, Commitments, and Contingencies,” in the Notes to Consolidated Financial Statements in Part II, Item 8 of this Form 10-K.
Contractual Obligations
In the table below, we set forth our enforceable and legally binding obligations and future commitments, andas well as obligations related to all contracts that we are likely to continue, regardless of the fact that they were cancelable as of December 31, 2005.2008. Some of the figures that we include in this table are based on management’s estimate and assumptions about these obligations, including their duration, the possibility of renewal, anticipated actions by third parties, and other factors. Because these estimates and assumptions are necessarily subjective, the obligations we will actually pay in future periods may vary from those reflected in the table.
Payments due by period (in millions) | ||||||||||||||||
Contractual Obligations | Total | Less than 1 year | 1 to 3 years | 3 to 5 years | More than 5 years | |||||||||||
Operating lease obligations and other(1) | $ | 181.2 | $ | 19.6 | $ | 41.3 | $ | 38.3 | $ | 82.0 | ||||||
Slough(2) | 543.7 | 8.9 | 50.0 | 71.9 | 412.9 | |||||||||||
Purchase obligations(3) | 1,590.4 | 937.9 | 491.9 | 132.5 | 28.1 | |||||||||||
Long-term debt(4) | 2,000.0 | - | - | 500.0 | 1,500.0 | |||||||||||
Litigation-related and other long-term liabilities(5) | 714.3 | 0.2 | 695.1 | 11.2 | 7.8 | |||||||||||
| Total | $ | 5,029.6 | $ | 966.6 | $ | 1,278.3 | $ | 753.9 | $ | 2,030.8 | ||||||
Payments Due by Period (in millions) | ||||||||||||||||||||
| Contractual Obligations | Total | 2009 | 2010 and 2011 | 2012 and 2013 | 2014 and Beyond | |||||||||||||||
Operating lease and lease-related obligations(1) | $ | 257 | $ | 36 | $ | 70 | $ | 60 | $ | 91 | ||||||||||
HCP(2) (Financing lease) | 491 | 36 | 76 | 81 | 298 | |||||||||||||||
Lonza(3) (Singapore facility agreement) | 215 | – | 90 | 125 | – | |||||||||||||||
Purchase obligations(4) | 1,057 | 702 | 279 | 76 | – | |||||||||||||||
Long-term debt(5) | 2,000 | – | 500 | – | 1,500 | |||||||||||||||
Deferred tax liabilities(6) | 46 | 46 | – | – | – | |||||||||||||||
Other long-term liabilities(7) | 31 | 2 | 4 | 5 | 20 | |||||||||||||||
Interest expense on long-term debt(8) | 1,022 | 85 | 151 | 148 | 638 | |||||||||||||||
| Total | $ | 5,119 | $ | 907 | $ | 1,170 | $ | 495 | $ | 2,547 | ||||||||||
________________________
| (1) | Operating lease obligations include Owner Association Fees on buildings that we own. |
| (2) | See further |
| (3) | Included in “2010 and 2011” is a manufacturing milestone payment. We also entered into a loan agreement, subject to certain mutually acceptable conditions of securitization, with Lonza to advance up to $290 million to Lonza for the construction of their Singapore facility, and $9 million for a related land lease option, of which $225 million was advanced as of December 31, 2008. If we exercise our option to purchase the facility, any outstanding advances may be offset against the purchase price. If we do not exercise our purchase option, the advances will be offset against supply purchases. The supply purchases presented in the table above have been offset by the advances made to Lonza as of December 31, 2008. See further discussion of the agreements with Lonza above in “Off-Balance Sheet Arrangements” and in Note 9, “Leases, Commitments, and Contingencies,” in the Notes to Consolidated Financial Statements in Part II, Item 8 of this Form 10-K. |
| (4) | Purchase obligations include commitments related to capital expenditures, clinical development, |
| (5) | |
| (6) | Amount represents the current portion of our tax obligations and |
| (7) | Other long-term liabilities |
| (8) | Interest expense includes the effects of an interest rate swap agreement. See also, Note 4 “Investment Securities and |
| Excludes | |
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In addition to the above, we have committed to make potential future “milestone”milestone payments to third-partiesthird parties as well as fund certain development, manufacturing and commercialization efforts as part of in-licensing and joint product development programs. PaymentsMilestone payments under these agreements generally become due and payable only upon achievement of certain developmental, regulatory, and/or commercial milestones. Because the achievement of these milestones is generally neither probable nor reasonably estimable, such contingencies have not been recorded on our consolidated balance sheet.
Stock Options
Option Program Description
Our employee stock option program is a broad-based, long-term retention program that is intended to attract and retain talented employees and to align stockholder and employee interests. Our program primarily consists of our amended and restated 1999 Stock2004 Equity Incentive Plan (the “Plan”)Plan), a broad-based plan under which stock options, arerestricted stock, stock appreciation rights, and performance shares and units may be granted to employees, directors, and other service providers. Substantially all of our employees participate in our stock option program. In the past, we granted options under our amended and restated 1999 Stock Plan, 1996 Stock Option/Stock Incentive Plan, our amended and restated 1994 Stock Option Plan, and our amended and restated 1990 Stock Option/Stock Incentive Plan. Although we no longer grant options under these plans, exercisable options granted under almost all of these plans are still outstanding. In addition,
On August 18, 2008, the Special Committee adopted two retention plans that were implemented in lieu of our stockholders approved our 2004 Equity Incentive Plan under2008 annual stock option grant, which stock options, restricted stock, stock appreciation rights and performance shares and units may be granted totypically occurs in September. The plans cover substantially all of our employees, directorsincluding our named executive officers. See “Relationship with Roche Holdings, Inc.” for more information about the Roche Proposal, and consultants insee “Liquidity and Capital Resources” for more information about the future.retention plans.
General Option Information
Summary of Option Activity
(Shares in thousands)millions)
Options Outstanding | ||||||||||
Shares Available for Grant | Number of Shares | Weighted Average Exercise Price | ||||||||
December 31, 2003 | 40,732 | 96,126 | $ | 25.18 | ||||||
| Grants | (20,967 | ) | 20,967 | 53.04 | ||||||
| Exercises | - | (21,484 | ) | 20.81 | ||||||
| Cancellations | 1,843 | (1,843 | ) | 29.92 | ||||||
Additional shares reserved(1) | 80,000 | - | - | |||||||
December 31, 2004 | 101,608 | 93,766 | $ | 32.32 | ||||||
| Grants | (19,675 | ) | 19,675 | 84.01 | ||||||
| Exercises | - | (28,823 | ) | 25.88 | ||||||
| Cancellations | 1,814 | (1,814 | ) | 42.16 | ||||||
December 31, 2005 | 83,747 | 82,804 | $ | 46.64 | ||||||
Options Outstanding | ||||||||||||
Shares Available for Grant | Number of Shares | Weighted Average Exercise Price | ||||||||||
| December 31, 2006 | 70 | 88 | $ | 54.53 | ||||||||
| Grants | (18 | ) | 18 | 79.40 | ||||||||
| Exercises | – | (10 | ) | 32.76 | ||||||||
| Cancellations | 4 | (4 | ) | 76.45 | ||||||||
| December 31, 2007 | 56 | 92 | 60.94 | |||||||||
| Grants | (1 | ) | 1 | 79.23 | ||||||||
| Exercises | – | (13 | ) | 44.83 | ||||||||
| Cancellations | 3 | (3 | ) | 80.52 | ||||||||
| December 31, 2008 | 58 | 77 | $ | 63.06 | ||||||||
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In-the-Money and Out-of-the-Money Option Information
(Shares in thousands)millions)
Exercisable | Unexercisable | Total | |||||||||||||||||
As of December 31, 2005 | Shares | Wtd. Avg. Exercise Price | Shares | Wtd. Avg. Exercise Price | Shares | Wtd. Avg. Exercise Price | |||||||||||||
| In-the-Money | 37,451 | $ | 29.39 | 44,878 | $ | 60.51 | 82,329 | $ | 46.36 | ||||||||||
Out-of-the-Money(1) | - | - | 475 | 95.02 | 475 | 95.02 | |||||||||||||
| Total Options Outstanding | 37,451 | 45,353 | 82,804 | ||||||||||||||||
Exercisable | Unexercisable | Total | ||||||||||||||||||||||
| As of December 31, 2008 | Shares | Wtd. Avg. Exercise Price | Shares | Wtd. Avg. Exercise Price | Shares | Wtd. Avg. Exercise Price | ||||||||||||||||||
| In-the-money | 45 | $ | 49.01 | 18 | $ | 79.01 | 63 | $ | 57.59 | |||||||||||||||
Out-of-the-money(1) | 11 | 86.28 | 3 | 86.67 | 14 | 86.37 | ||||||||||||||||||
| Total options outstanding | 56 | 21 | 77 | |||||||||||||||||||||
________________________
| (1) | Out-of-the-money options are those options with an exercise price equal to or greater than the fair market value of Genentech Common Stock, which was |
Distribution and Dilutive Effect of Options
Employee and Executive Officer Option Grants
2005* | 2004* | 2003* | ||||||
| Net grants during the year as % of outstanding shares | 1.70 | % | 1.83 | % | 1.69 | % | ||
| Grants to Executive Officers during the period as % of outstanding shares | 0.18 | % | 0.25 | % | 0.24 | % | ||
| Grants to Executive Officers during the year as % of total options granted | 9.44 | % | 12.29 | % | 11.16 | % | ||
2008(1) | 2007(1) | 2006(1) | ||||||||||
| Grants, net of forfeitures, during the year as % of outstanding shares | (0.20 | ) % | 1.36 | % | 1.43 | % | ||||||
| Grants to Executive Officers during the period as % of outstanding shares | – | % | 0.13 | % | 0.14 | % | ||||||
| Grants to Executive Officers during the year as % of total options granted | – | % | 7.41 | % | 8.60 | % | ||||||
________________________
| Executive officers as of December 31 for the years presented. |
Equity Compensation Plan Information
Our stockholders have approved all of our equity compensation plans under which options are outstanding.
******
This report contains forward-looking statements regarding our Horizon 2010 strategy of bringing new molecules into clinical development, bringing major new products or indications onto the completionmarket, becoming the number one U.S. oncology company in sales, and achieving certain financial growth measures; the initiation of phasesa clinical study for Avastin; the availability and timing of data for clinical studies for Avastin; Avastin regulatory approvalfilings; a Tarceva sNDA submission; share repurchases; the cost of development projects; coststhe retention plans in response to the Roche proposal to acquire all of the outstanding shares of our Common Stock not owned by Roche; label extensions for compliance with environmental laws; construction,Xolair; Raptiva inventory impairment; qualification and licensure of our new Vacaville plant; manufacturing of Avastin bulk drug substance at andfacility, licensure of our manufacturingHillsboro facility in Oceanside, California; manufacturingand Lonza’s and our Singapore facilities, and completion of Herceptin at and licensure of Wyeth’s production facility in Andover, Massachusetts; licensure of yield improvements and processesconstruction for our Dixon facility; liability with respect to COH; liability with respect to Lonza; the production of Rituxan and Avastin; the conditionadequacy of our existing manufacturing facilities and our abilitycapital resources to meet long-term manufacturing needs;growth; the effectstiming of the Medicare Prescription Drug Improvement and Modernization Act on our revenues; our abilitySpecial Committee’s formal position with respect to deliver sustainable growth; growth from the use in potential new but unapproved uses of Avastin; Herceptin sales growth; Tarceva’s share of the oral EGFR class;Roche Tender Offer; sales to collaborators; Tarceva, Rituxancontractual obligations; tax obligations and Xolair product sales; royalty and contract revenues; cost of sales as a percentage of net product sales; research and development costs and R&D as a percentage of operating revenue; marketing, general and administrative expenses and MG&A as a percentage of operating revenue; operating margin; interest income; annualour effective income tax rate; capital expenditures; lease payments; and the effect of recent accounting pronouncements on our ability to meet our foreseeable operating cash requirements.financial statements.
These forward-looking statements involve risks and uncertainties, and the cautionary statements set forth below and those contained in “Risk Factors” in this Annual Report on Form 10-K identify important factors that could cause actual results to differ materially from those predicted in any such forward-looking statements. Such factors include, but are not limited to, difficulty in enrolling patients in clinical trials; the need for additional data, data analysis or clinical studies; BLA preparation and decision making; FDA actions or delays; failure to comply with environmental laws; difficulties or delays in obtaining licensure of manufacturing facilities, beginning or continuing production at manufacturing facilities, or obtaining licensure of yield improvement processes; decreases in third-party reimbursement rates; failure to successfully develop biotherapeutics and obtain or maintain, or changes to, FDA or other regulatory approval for our products; competition; litigation;approval; difficulty in obtaining materials from suppliers; unexpected safety, efficacy or manufacturing issues failurefor us or our contract/collaborator manufacturers; increased capital expenditures including greater than expected construction and validation costs; product withdrawals or suspensions; competition; efficacy data concerning any of our products which shows or is perceived to show similar or improved treatment benefit at a lower dose or shorter duration of therapy; pricing decisions by us or our competitors; our ability to protect our proprietary rights; failurethe outcome of, and expenses associated with, litigation or legal settlements; increased R&D, MG&A, stock-based compensation, environmental and other expenses, inventory write-offs, and increased COS; variations in collaborator sales and expenses; fluctuations in contract revenues and royalties; our indebtedness and ability to attract and retain skilled personnel;pay our indebtedness; actions by Roche that are adverse to our interests; increased research and development, marketing, and general and administrative costs; a decreasedevelopments regarding the Roche Tender Offer; decreases in interestthird party reimbursement rates; an increasethe ability of wholesalers to effectively distribute our effectiveproducts; greater than expected income tax rate; and inability to pay our indebtedness.changes in accounting or tax laws or the application or interpretation of such laws. We disclaim and do not undertake any obligation to update or revise any forward-looking statementsstatement in this Annual Report on Form 10-K.10-K.
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We are exposed to market risk, including changes to interest rates, foreign currency exchange rates and equity investment prices. To reduce the volatility relatingrelated to these exposures, we enter into various derivative hedging transactions pursuant to our investment and risk management policies and procedures. We do not useenter into derivatives for speculative purposes.
The estimated exposures discussed below are intended to measure the maximum amount that we could lose from adverse market movements in interest rates, foreign currency exchange rates, and equity investment prices, given a specified confidence level, over a given period of time. Loss is defined in the value at riskvalue-at-risk (VAR) estimation as fair market value loss. The exposures to interest rate, foreign currency exchange rateOur VAR model utilizes historical simulation of daily market data over the past three years and equity investment pricecalculates market data changes are calculated based on proprietary modeling techniques from a Monte Carlo simulation value at risk model using a 21-trading days21-trading-day holding period andto estimate expected loss in fair value at a 95% confidence level. The value atVAR model is not intended to represent actual losses but is used as a risk model assumes non-linear financial returns and generates potential paths variousestimation tool. The calculated VAR is intended to measure the amount that we could lose from adverse market prices could take and tracks the hypothetical performance of a portfolio under each scenario to approximate its financial return. The value at risk model takes into account correlations and diversification across market factors, includingmovements in interest rates, foreign currenciescurrency exchange rates, and equity prices. Hedge instrumentsinvestment prices, given a specified confidence level, over a given period of time. However, our VAR calculations are modeled as positions onnot designed to fully factor in all potential future volatility because the actual underlying securities. No proxies were used. Market volatilities and correlationscalculations are based on a one-year historical time-series asresults that may not be predictive of December 31, 2005 and December 31, 2004.future results.
Actual future gains and losses associated with our investment portfolio and derivative positions may differ materially from the VAR analyses performed due to the inherent limitations associated with predicting the timing and amount of changes to interest rates, foreign currency exchanges rates, and equity investment prices, as well as our actual exposures and positions.
Interest Rate Risk
Our material interest-bearing assets, or interest-bearing portfolio, consisted of cash, cash equivalents, restricted cash and investments, short-term investments, marketable debt securities, long-term investments and interest-bearing forward contracts. The balance of our interest-bearing portfolio, including restricted and unrestricted cash and investments, was $4,169.5$9,258 million, or 42% of total assets, at December 31, 2008; and $6,437 million, or 34% of total assets, at December 31, 2005 and $2,926.3 million of 31% of total assets at December 31, 2004.2007. Interest income related to this portfolio was $141.9$90 million in 20052008 and $90.5$270 million in 2004.2007. Our interest income is sensitive to changes in the general level of interest rates, primarily U.S. interest rates. In this regard, changes in U.S. interest rates affect the interest-bearing portfolio. To mitigate the effect of fluctuations in U.S. interest rates, for a portioncredit ratings of our portfolio, we enter into swap transactions that involveinvestments, and market liquidity for the receiptdifferent types of fixed rateinterest-bearing assets.
Our short-term borrowings include unsecured commercial paper notes payable of $500 million at December 31, 2008 and $600 million at December 31. 2007. These notes are not redeemable prior to maturity or subject to voluntary prepayment, and were issued on a discount basis. At December 31, 2008 and 2007, outstanding commercial paper notes carried an effective interest yield of 0.8% and the payment of floating rate interest without the exchange4.46%, respectively.
Our long-term debt is made up of the underlying principal.
Based on our overall interest rate exposure, includingwhich includes the net effect of our interest rate exposures on our interest-bearing assets, our Senior Notes, derivativesNote debt instruments, and other interest rate sensitive instruments,our commercial paper, using a near-term change in interest rates, within21-trading-day holding period with a 95% confidence level, based on historical interest rate movements could result in athe potential loss in estimated fair value of our interest rate sensitiverate-sensitive instruments of $34.0was $22 million at December 31, 20052008 and $7.4$20 million at December 31, 2004. The increase in 2005 is primarily the result2007. A significant portion of the July 2005 debt issuance.potential loss in estimated fair value at both December 31, 2008 and 2007 was attributed to the longer duration of our Senior Notes.
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Foreign Currency Exchange and Foreign Economic Conditions Risk
We receive royalty revenuesrevenue from licensees selling products in countries throughout the world. As a result, our financial results could be significantly affected by factors such as changes in foreign currency exchange rates or weak economic conditions in the foreign markets in which our licensed products are sold. WeOur exposure to foreign exchange rates is most significant relative to the Swiss Franc, though we are also exposed to changes in exchange rates elsewhere in Europe, Asia (primarily Japan), and Canada. Our exposure to foreign exchange rates primarily exists with the Swiss Franc. When the dollar strengthens against the currencies in these countries, the dollar value of foreign-currency denominatedforeign-currency-denominated revenue decreases; when the dollar weakens, the dollar value of the foreign-currency denominated revenuesforeign-currency-denominated revenue increases. Accordingly, changes in exchange rates, and in particular a strengthening of the dollar, may adversely affect our royalty revenuesrevenue as expressed in dollars. Expenses arising from our foreign manufacturing facility as well as non-dollar expenses incurred in our collaborations are offsetting exchange rate exposures on these royalties. Currently, our foreignforeign-currency-denominated royalty revenues exceed our foreignforeign-currency-denominated expenses. In addition, as part of our overall investment strategy, a portion of our investment portfolio is primarily in non-dollarnon-U.S. dollar denominated investments. As a result, we are exposed to changes in the exchange rates of the countriescurrencies in which these non-dollar denominatednon-U.S. dollar investments are made.denominated.
To mitigate our net foreign exchange exposure, our policy allows us to hedge certain of our anticipated royalty revenuesrevenue by purchasing option orentering into forward contracts or options, including collars, with oneone- to five yearfive-year expiration dates and amounts of currency
that are based on up to 90% of forecasted future revenuesrevenue so that the potential adverse effect of movements in currency exchange rates on the non-dollar denominated revenuesrevenue will be at least partly offset by an associated increase in the value of the option or forward. As of December 31, 2005,2008, these options and forwards are due to expire in 2006 through 2008. To hedge the non-dollar expenses arising from our foreign manufacturing facility, we enter into forward contracts to lock in the dollar value of a portion of these anticipated expenses.2009 and 2010.
Based on our overall currency rate exposure, at December 31, 2005, including derivative and other foreign currency sensitive instruments,using a near-term change in currency rates within21-trading-day holding period with a 95% confidence level, based on historical currency rate movements could result in athe potential loss in the estimated fair value of our foreign currency sensitivecurrency-sensitive instruments of $18.1was $69 million at December 31, 20052008 and $16.5$40 million at December 31, 2004.2007. Because we use foreign currency instruments to hedge anticipated future cash flows, losses incurred on those instruments are generally offset by increases in the fair value of the underlying future cash flows that they were intended to hedge.
Equity Security Risks
As part of our strategic alliance efforts, we have invested and may, in certain circumstances, invest in publicly traded equity instruments of biotechnology companies. Our biotechnology equity investment portfolio totaled $379.4$287 million, or 3%1% of total assets, at December 31, 20052008 and $536.2$416 million, or 6%2% of total assets, at December 31, 2004.2007. The decrease during 2008 was mainly due to sales of securities and lower market valuations. Impairment charges on our biotechnology equity investments were $16 million in 2008 and $20 million in 2007. These investments are subject to fluctuations from market value changes in stock prices. To mitigate the risk of market value fluctuation, our policy allows us to hedge certain equity securities are hedged with zero-cost collars andby entering into forward contracts. A zero-cost collar is a purchased putor option and a written call option in which the cost of the purchased put and the proceeds of the written call offset each other; therefore, there is no initial cost or cash outflow for these instruments at the time of purchase. The purchased put protects us from a decline in the market value of the security below a certain minimum level (the put “strike” level), while the call effectively limits our potential to benefit from an increase in the market value of the security above a certain maximum level (the call “strike” level). A forward contract is a derivative instrument where we lock-in the termination price we receive from the sale of stock based on a pre-determined spot price. The forward contract protects us from a decline in the market value of the security below the spot price and limits our potential benefit from an increase in the market value of the security above the spot price. Throughout the life of the contract, we receive interest income based on the notional amount and a floating-rate index. In addition, as part of our strategic alliance efforts, we hold convertible preferred stock, including dividend-bearing convertible preferred stock, and have made interest-bearing loans that are convertible into the equity securities of the debtor or repaid in cash.contracts. Depending on market conditions, we may determine that in future periods certain of our other unhedged equity security investments are impaired, which would result in additional write-downs of those equity security investments.
Based on our overall exposure to fluctuations from market value changes in marketable equity prices, using a near-term change in equity prices within21-trading-day holding period with a 95% confidence level, based on historic volatilities could result in athe potential loss in estimated fair value of our equity securities portfolio of $19.5was $17 million at December 31, 20052008 and $20.6$27 million at December 31, 2004.2007.
Also, as part of our strategic alliance efforts, we invest in privately held biotechnology companies, some of which are in the start-up stage. These investments are primarily carried at cost, which were $32 million at December 31, 2008 and $31 million at December 31, 2007, and are recorded in “Other long-term assets” in the Consolidated Balance Sheets. Our determination of investment values in private companies is based on the fundamentals of the businesses, including, among other factors, the nature and success of their R&D efforts.
Counterparty Credit Risks
Report of Independent Registered Public Accounting Firm
The Board of Directors and Stockholders of Genentech, Inc.
We have audited the accompanying consolidated balance sheets of Genentech, Inc. as of December 31, 20052008 and 2004,2007, and the related consolidated statements of income, stockholders’ equity and cash flows for each of the three years in the period ended December 31, 2005.2008. Our audits also included the financial statement schedule listed in the Index at Item 15(a). These financial statements and schedule are the responsibility of Genentech, Inc.’s management. Our responsibility is to express an opinion on these financial statements and schedule based on our audits.
We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.
In our opinion, the financial statements referred to above present fairly, in all material respects, the consolidated financial position of Genentech, Inc. at December 31, 20052008 and 2004,2007, and the consolidated results of its operations and its cash flows for each of the three years in the period ended December 31, 2005,2008, in conformity with U.S. generally accepted accounting principles. Also, in our opinion, the related financial statement schedule, when considered in relation to the basic financial statements taken as a whole, presents fairly in all material respects the information set forth therein.
We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the effectiveness of Genentech, Inc.’s internal control over financial reporting as of December 31, 2005,2008, based on criteria established in Internal Control — Control—Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission and our report dated February 10, 20064, 2009 expressed an unqualified opinion thereon.
| /s/ Ernst & Young LLP |
Palo Alto, California
February 10, 20064, 2009,
except for the first paragraph of Note 3
and the thirteenth paragraph of Note 10,
as to which the date is
February 9, 2009
CONSOLIDATED STATEMENTS OF INCOME
(in thousands,In millions, except per share amounts)
Year Ended December 31, | ||||||||||
2005 | 2004 | 2003 | ||||||||
Revenues | ||||||||||
Product sales (including amounts from related parties: 2005-$183,664; 2004-$112,065; 2003-$108,078) | $ | 5,488,058 | $ | 3,748,879 | $ | 2,621,490 | ||||
Royalties (including amounts from a related party: 2005-$485,357; 2004-$338,733; 2003-$245,623) | 935,112 | 641,119 | 500,903 | |||||||
Contract revenue (including amounts from related parties: 2005-$115,067; 2004-$121,261; 2003-$90,692) | 210,202 | 231,159 | 177,934 | |||||||
Total operating revenues | 6,633,372 | 4,621,157 | 3,300,327 | |||||||
Costs and expenses | ||||||||||
Cost of sales (including amounts for related parties: 2005-$171,200; 2004-$96,091; 2003-$90,657) | 1,011,069 | 672,526 | 480,123 | |||||||
Research and development (including amounts for related parties: 2005-$203,942; 2004-$171,979; 2003-$102,234) (including contract related: 2005-$110,918; 2004-$131,636; 2003-$95,473) | 1,261,824 | 947,513 | 721,970 | |||||||
| Marketing, general and administrative | 1,435,025 | 1,088,111 | 794,845 | |||||||
Collaboration profit sharing (including amounts for a related party: 2005-$136,353; 2004-$75,090; 2003-$9,898) | 823,083 | 593,616 | 457,457 | |||||||
| Recurring charges related to redemption | 122,746 | 145,485 | 154,344 | |||||||
| Special items: litigation-related | 57,774 | 37,087 | (113,127 | ) | ||||||
Total costs and expenses | 4,711,521 | 3,484,338 | 2,495,612 | |||||||
| Operating income | 1,921,851 | 1,136,819 | 804,715 | |||||||
| Other income (expense): | ||||||||||
| Interest and other income (expense), net | 140,927 | 89,997 | 95,728 | |||||||
| Interest expense | (49,929 | ) | (7,400 | ) | (2,937 | ) | ||||
| Total other income, net | 90,998 | 82,597 | 92,791 | |||||||
| Income before taxes and cumulative effect of accounting change | 2,012,849 | 1,219,416 | 897,506 | |||||||
| Income tax provision | 733,858 | 434,600 | 287,324 | |||||||
| Income before cumulative effect of accounting change | 1,278,991 | 784,816 | 610,182 | |||||||
| Cumulative effect of accounting change (net of tax: 2003-$31,770) | - | - | (47,655 | ) | ||||||
Net income | $ | 1,278,991 | $ | 784,816 | $ | 562,527 | ||||
Earnings per share | ||||||||||
Basic | ||||||||||
| Earnings before cumulative effect of accounting change | $ | 1.21 | $ | 0.74 | $ | 0.59 | ||||
| Cumulative effect of accounting change (net of tax: 2003-$0.03) | - | - | (0.05 | ) | ||||||
| Net earnings per share | $ | 1.21 | $ | 0.74 | $ | 0.54 | ||||
Diluted | ||||||||||
| Earnings before cumulative effect of accounting change | $ | 1.18 | $ | 0.73 | $ | 0.58 | ||||
| Cumulative effect of accounting change (net of tax: 2003-$0.03) | - | - | (0.05 | ) | ||||||
| Net earnings per share | $ | 1.18 | $ | 0.73 | $ | 0.53 | ||||
| Shares used to compute basic earnings per share | 1,054,952 | 1,055,165 | 1,034,480 | |||||||
| Shares used to compute diluted earnings per share | 1,080,949 | 1,079,209 | 1,057,619 | |||||||
Year Ended December 31, | ||||||||||||
2008 | 2007 | 2006 | ||||||||||
| Revenue | ||||||||||||
Product sales (including amounts from related parties: 2008-$880; 2007-$778; 2006-$364) | $ | 10,531 | $ | 9,443 | $ | 7,640 | ||||||
Royalties (including amounts from related parties: 2008-$1,785; 2007-$1,301; 2006-$849) | 2,539 | 1,984 | 1,354 | |||||||||
Contract revenue (including amounts from related parties: 2008-$198; 2007-$165; 2006-$165) | 348 | 297 | 290 | |||||||||
| Total operating revenue | 13,418 | 11,724 | 9,284 | |||||||||
| Costs and expenses | ||||||||||||
Cost of sales (including amounts for related parties: 2008-$481; 2007-$432; 2006-$272) | 1,744 | 1,571 | 1,181 | |||||||||
Research and development (including amounts from programs where related parties share costs: 2008-$379; 2007-$302; 2006-$251) (including amounts for which reimbursement was recorded as contract revenue: 2008-$227; 2007-$196; 2006-$185) | 2,800 | 2,446 | 1,773 | |||||||||
| Marketing, general and administrative | 2,405 | 2,256 | 2,014 | |||||||||
Collaboration profit sharing (including related party amounts: 2008-$189; 2007-$185; 2006-$187) | 1,228 | 1,080 | 1,005 | |||||||||
| Write-off of in-process research and development related to acquisition | – | 77 | – | |||||||||
| Gain on acquisition | – | (121 | ) | – | ||||||||
| Recurring amortization charges related to redemption and acquisition | 172 | 132 | 105 | |||||||||
| Special items: litigation-related | (260 | ) | 54 | 54 | ||||||||
| Total costs and expenses | 8,089 | 7,495 | 6,132 | |||||||||
| Operating income | 5,329 | 4,229 | 3,152 | |||||||||
| Other income (expense): | ||||||||||||
| Interest and other income, net | 184 | 273 | 325 | |||||||||
| Interest expense | (82 | ) | (76 | ) | (74 | ) | ||||||
| Total other income, net | 102 | 197 | 251 | |||||||||
| Income before taxes | 5,431 | 4,426 | 3,403 | |||||||||
| Income tax provision | 2,004 | 1,657 | 1,290 | |||||||||
| Net income | $ | 3,427 | $ | 2,769 | $ | 2,113 | ||||||
| Earnings per share | ||||||||||||
| Basic | $ | 3.25 | $ | 2.63 | $ | 2.01 | ||||||
| Diluted | $ | 3.21 | $ | 2.59 | $ | 1.97 | ||||||
| Shares used to compute basic earnings per share | 1,053 | 1,053 | 1,053 | |||||||||
| Shares used to compute diluted earnings per share | 1,067 | 1,069 | 1,073 | |||||||||
See Notes to Consolidated Financial Statements.
CONSOLIDATED STATEMENTS OF CASH FLOWS
(in thousands)In millions)
Year Ended December 31, | ||||||||||
2005 | 2004 | 2003 | ||||||||
Cash flows from operating activities | ||||||||||
| Net income | $ | 1,278,991 | $ | 784,816 | $ | 562,527 | ||||
| Adjustments to reconcile net income to net cash provided by operating activities: | ||||||||||
| Cumulative effect of accounting change, net of tax | - | - | 47,655 | |||||||
| Depreciation and amortization | 370,166 | 353,221 | 295,449 | |||||||
| Deferred income taxes | (109,695 | ) | (73,585 | ) | (149,001 | ) | ||||
| Deferred revenue | (49,375 | ) | (14,927 | ) | 239,145 | |||||
| Litigation-related liabilities | 51,424 | 34,722 | 56,113 | |||||||
| Tax benefit from employee stock options | 632,300 | 329,470 | 264,981 | |||||||
| Gain on sales of securities available-for-sale and other | (11,606 | ) | (13,577 | ) | (23,069 | ) | ||||
| Loss on sales of securities available-for-sale | 3,164 | 1,839 | 3,137 | |||||||
| Write-down of securities available-for-sale and other | 10,044 | 12,340 | 3,795 | |||||||
| Loss on fixed asset dispositions | 9,650 | 5,115 | 10,760 | |||||||
| Changes in assets and liabilities: | ||||||||||
| Receivables and other current assets | (129,118 | ) | (363,805 | ) | (146,892 | ) | ||||
| Inventories | (112,172 | ) | (120,703 | ) | (93,264 | ) | ||||
| Investments in trading securities | (17,409 | ) | (75,695 | ) | (33,825 | ) | ||||
| Accounts payable, other accrued liabilities, and other long-term liabilities | 437,549 | 335,542 | 204,610 | |||||||
Net cash provided by operating activities | 2,363,913 | 1,194,773 | 1,242,121 | |||||||
Cash flows from investing activities | ||||||||||
| Purchases of securities available-for-sale | (999,596 | ) | (889,732 | ) | (1,755,934 | ) | ||||
| Proceeds from sales and maturities of securities available-for-sale | 721,678 | 1,149,113 | 739,867 | |||||||
| Purchases of nonmarketable equity securities | (2,601 | ) | (6,661 | ) | (4,286 | ) | ||||
| Capital expenditures | (1,399,824 | ) | (649,858 | ) | (321,955 | ) | ||||
| Change in other assets | (42,716 | ) | (57,955 | ) | (61,307 | ) | ||||
| Transfer (to) from restricted cash, net | (53,000 | ) | 4,600 | - | ||||||
Net cash used in investing activities | (1,776,059 | ) | (450,493 | ) | (1,403,615 | ) | ||||
Cash flows from financing activities | ||||||||||
| Stock issuances | 820,493 | 505,374 | 526,861 | |||||||
| Stock repurchases | (2,015,912 | ) | (1,351,683 | ) | (201,345 | ) | ||||
| Repayment of long-term debt and noncontrolling interest | (425,000 | ) | - | - | ||||||
| Proceeds from issuance of long-term debt | 1,987,953 | - | - | |||||||
Net cash provided by (used in) financing activities | 367,534 | (846,309 | ) | 325,516 | ||||||
| Net increase (decrease) in cash and cash equivalents | 955,388 | (102,029 | ) | 164,022 | ||||||
| Cash and cash equivalents at beginning of year | 270,123 | 372,152 | 208,130 | |||||||
Cash and cash equivalents at end of year | $ | 1,225,511 | $ | 270,123 | $ | 372,152 | ||||
Supplemental cash flow data | ||||||||||
| Cash paid during the year for: | ||||||||||
| Interest | $ | 9,727 | $ | 6,626 | $ | 2,223 | ||||
| Income taxes | 311,571 | 131,611 | 167,761 | |||||||
| Non-cash investing and financing activities | ||||||||||
| Capitalization of construction in progress related to financing lease transaction | 93,559 | - | - | |||||||
| Exchange of XOMA note receivable for a prepaid royalty and other long-term asset | 29,205 | - | - | |||||||
| Stock received as consideration for outstanding loans | - | - | 29,600 | |||||||
Year Ended December 31, | ||||||||||||
2008 | 2007 | 2006 | ||||||||||
| Cash flows from operating activities | ||||||||||||
| Net income | $ | 3,427 | $ | 2,769 | $ | 2,113 | ||||||
| Adjustments to reconcile net income to net cash provided by operating activities: | ||||||||||||
| Depreciation and amortization | 592 | 492 | 407 | |||||||||
| Employee stock-based compensation | 399 | 403 | 309 | |||||||||
| Excess tax benefit from stock-based compensation arrangements | (140 | ) | (193 | ) | (179 | ) | ||||||
| Acquired in-process research and development | – | 77 | – | |||||||||
| Gain on acquisition | – | (121 | ) | – | ||||||||
| Deferred income taxes | 90 | (234 | ) | (112 | ) | |||||||
| Deferred revenue | 41 | (68 | ) | (3 | ) | |||||||
| Litigation-related special items | (260 | ) | 51 | 51 | ||||||||
| Gain on sales of securities available-for-sale and other | (124 | ) | (27 | ) | (94 | ) | ||||||
| Loss on sales and write-downs of securities available-for-sale and other | 149 | 58 | 5 | |||||||||
| Loss on fixed asset dispositions | 26 | 32 | 23 | |||||||||
| Changes in assets and liabilities: | ||||||||||||
| Receivables and other assets | (132 | ) | 38 | (628 | ) | |||||||
| Inventories | 209 | (310 | ) | (408 | ) | |||||||
| Investments in trading securities | 82 | (360 | ) | (29 | ) | |||||||
| Accounts payable, other accrued liabilities, and other long-term liabilities | 72 | 623 | 683 | |||||||||
| Accrued litigation | (476 | ) | – | – | ||||||||
| Net cash provided by operating activities | 3,955 | 3,230 | 2,138 | |||||||||
| Cash flows from investing activities | ||||||||||||
| Purchases of securities available-for-sale | (2,980 | ) | (1,152 | ) | (1,036 | ) | ||||||
| Proceeds from sales of securities available-for-sale | 1,770 | 651 | 256 | |||||||||
| Proceeds from maturities of securities available-for-sale | 279 | 486 | 357 | |||||||||
| Capital expenditures | (751 | ) | (977 | ) | (1,214 | ) | ||||||
| Change in other intangible and long-term assets | 15 | (40 | ) | 9 | ||||||||
| Acquisition and related costs, net | – | (833 | ) | – | ||||||||
| Transfer to restricted cash, net | – | – | (53 | ) | ||||||||
| Net cash used in investing activities | (1,667 | ) | (1,865 | ) | (1,681 | ) | ||||||
| Cash flows from financing activities | ||||||||||||
| Stock issuances | 680 | 452 | 385 | |||||||||
| Stock repurchases and prepaid share repurchase deposits | (780 | ) | (1,345 | ) | (996 | ) | ||||||
| Excess tax benefit from stock-based compensation arrangements | 140 | 193 | 179 | |||||||||
| Proceeds from (maturities of) commercial paper, net | (99 | ) | 599 | – | ||||||||
| Construction financing and other related payments | (210 | ) | – | – | ||||||||
| Net cash used in financing activities | (269 | ) | (101 | ) | (432 | ) | ||||||
| Net increase in cash and cash equivalents | 2,019 | 1,264 | 25 | |||||||||
| Cash and cash equivalents at beginning of year | 2,514 | 1,250 | 1,225 | |||||||||
| Cash and cash equivalents at end of year | $ | 4,533 | $ | 2,514 | $ | 1,250 | ||||||
| Supplemental cash flow data | ||||||||||||
| Cash paid during the year for: | ||||||||||||
| Interest | $ | 74 | $ | 60 | $ | 68 | ||||||
| Income taxes | 1,779 | 1,673 | 1,038 | |||||||||
| Non-cash investing and financing activities | ||||||||||||
| Capitalization of construction in progress related to financing lease transactions | 117 | 203 | 128 | |||||||||
| Sale of subsidiary in exchange for note receivable | – | – | 135 | |||||||||
| Transfer of restricted cash to short-term investments | 788 | – | – | |||||||||
| Transfer of trading securities to available-for-sale | 122 | – | – | |||||||||
See Notes to Consolidated Financial Statements.
CONSOLIDATED BALANCE SHEETS
(in thousands,In millions, except par value and shares)value)
December 31, | |||||||
2005 | 2004 | ||||||
Assets | |||||||
| Current assets | |||||||
| Cash and cash equivalents | $ | 1,225,511 | $ | 270,123 | |||
| Short-term investments | 1,139,650 | 1,394,982 | |||||
Accounts receivable - product sales (net of allowances: 2005-$83,262; 2004-$59,366; including amounts from related parties: 2005-$3,603; 2004-$11,237) | 554,455 | 599,052 | |||||
Accounts receivable - royalties (including amounts from related party: 2005-$173,193; 2004-$119,080) | 296,664 | 217,482 | |||||
Accounts receivable - other (net of allowances: 2005-$582; 2004-$2,191; including amounts from related parties: 2005-$131,874; 2004-$68,594) | 232,297 | 143,421 | |||||
| Inventories | 702,515 | 590,343 | |||||
| Deferred tax assets | 166,561 | 148,370 | |||||
| Prepaid expenses and other current assets | 101,126 | 61,567 | |||||
| Total current assets | 4,418,779 | 3,425,340 | |||||
| Long-term marketable debt and equity securities | 1,448,731 | 1,115,327 | |||||
| Property, plant and equipment, net | 3,349,352 | 2,091,404 | |||||
| Goodwill | 1,315,019 | 1,315,019 | |||||
| Other intangible assets | 573,779 | 668,391 | |||||
| Restricted cash and investments | 735,000 | 682,000 | |||||
| Deferred tax assets | 145,910 | 20,341 | |||||
| Other long-term assets | 160,309 | 85,573 | |||||
Total assets | $ | 12,146,879 | $ | 9,403,395 | |||
Liabilities and stockholders’ equity | |||||||
| Current liabilities | |||||||
Accounts payable (including amounts to related parties: 2005-$1,379; 2004-$0) | $ | 338,978 | $ | 104,832 | |||
| Deferred revenue | 44,327 | 45,989 | |||||
Other accrued liabilities (including amounts to related parties: 2005-$131,774; 2004-$108,416) | 1,276,527 | 1,087,209 | |||||
| Total current liabilities | 1,659,832 | 1,238,030 | |||||
| Long-term debt | 2,083,024 | 412,250 | |||||
| Deferred revenue | 220,093 | 267,805 | |||||
| Litigation-related and other long-term liabilities | 714,346 | 703,120 | |||||
| Total liabilities | 4,677,295 | 2,621,205 | |||||
| Commitments and contingencies (Note 7) | |||||||
| Stockholders’ equity | |||||||
| Preferred stock, $0.02 par value; authorized: 100,000,000 shares; none issued | - | - | |||||
Common Stock, $0.02 par value; authorized: 3,000,000,000 shares; outstanding: 2005-1,053,712,934 shares; 2004-1,047,126,660 shares | 21,074 | 20,943 | |||||
| Additional paid-in capital | 9,262,679 | 8,002,754 | |||||
| Accumulated other comprehensive income | 253,422 | 290,948 | |||||
| Accumulated deficit, since June 30, 1999 | (2,067,591 | ) | (1,532,455 | ) | |||
| Total stockholders’ equity | 7,469,584 | 6,782,190 | |||||
Total liabilities and stockholders’ equity | $ | 12,146,879 | $ | 9,403,395 | |||
December 31, | ||||||||
2008 | 2007 | |||||||
| Assets | ||||||||
| Current assets | ||||||||
| Cash and cash equivalents | $ | 4,533 | $ | 2,514 | ||||
| Short-term investments | 1,665 | 1,461 | ||||||
| Restricted cash and investments | – | 788 | ||||||
Accounts receivable—product sales (net of allowances: 2008-$157; 2007-$116; including amounts from related parties: 2008-$203; 2007-$2) | 1,039 | 847 | ||||||
Accounts receivable—royalties (including amounts from related parties: 2008-$564; 2007-$463) | 680 | 620 | ||||||
Accounts receivable—other (including amounts from related parties: 2008-$122; 2007-$233) | 222 | 299 | ||||||
| Inventories | 1,299 | 1,493 | ||||||
| Deferred tax assets | 500 | 614 | ||||||
| Prepaid expenses and other current assets | 135 | 117 | ||||||
| Total current assets | 10,073 | 8,753 | ||||||
| Long-term marketable debt and equity securities | 3,347 | 2,090 | ||||||
| Property, plant and equipment, net | 5,404 | 4,986 | ||||||
| Goodwill | 1,590 | 1,577 | ||||||
| Other intangible assets | 1,008 | 1,168 | ||||||
| Other long-term assets | 365 | 366 | ||||||
| Total assets | $ | 21,787 | $ | 18,940 | ||||
| Liabilities and stockholders’ equity | ||||||||
| Current liabilities | ||||||||
Accounts payable (including amounts to related parties: 2008-$23; 2007-$2) | 228 | $ | 420 | |||||
| Commercial paper | 500 | 599 | ||||||
Deferred revenue (including amounts from related parties: 2008-$81; 2007-$63) | 88 | 73 | ||||||
| Accrued litigation | – | 776 | ||||||
Other accrued liabilities (including amounts to related parties: 2008-$180; 2007-$230) | 2,279 | 2,050 | ||||||
| Total current liabilities | 3,095 | 3,918 | ||||||
| Long-term debt | 2,329 | 2,402 | ||||||
Deferred revenue (including amounts from related parties: 2008-$380; 2007-$384) | 444 | 418 | ||||||
| Other long-term liabilities | 248 | 297 | ||||||
| Total liabilities | 6,116 | 7,035 | ||||||
| Commitments and contingencies (Note 9) | ||||||||
| Stockholders’ equity | ||||||||
| Preferred stock, $0.02 par value; authorized: 100 shares; none issued | – | – | ||||||
Common Stock, $0.02 par value; authorized: 3,000 shares; outstanding: 2008-1,053 shares; 2007-1,052 shares | 21 | 21 | ||||||
| Additional paid-in capital | 12,044 | 10,695 | ||||||
| Accumulated other comprehensive income | 124 | 197 | ||||||
| Retained earnings, since June 30, 1999 | 3,482 | 992 | ||||||
| Total stockholders’ equity | 15,671 | 11,905 | ||||||
| Total liabilities and stockholders’ equity | $ | 21,787 | $ | 18,940 | ||||
See Notes to Consolidated Financial Statements.
CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY
(in thousands)
Common Stock | |||||||||||||||||||
Shares | Amounts | Additional Paid-in Capital | Accumulated Deficit | Accumulated Other Comprehensive Income | Total | ||||||||||||||
Balance December 31, 2002 | 1,025,620 | $ | 20,512 | $ | 6,639,824 | $ | (1,590,094 | ) | $ | 268,642 | $ | 5,338,884 | |||||||
| Comprehensive income | |||||||||||||||||||
| Net income | - | - | - | 562,527 | - | 562,527 | |||||||||||||
| Changes in unrealized gain on securities available-for-sale, net of tax | - | - | - | - | 29,249 | 29,249 | |||||||||||||
| Changes in fair value of cash flow hedges, net of tax | - | - | - | - | (858 | ) | (858 | ) | |||||||||||
| Comprehensive income | 590,918 | ||||||||||||||||||
| Issuance of stock upon exercise of options | 32,078 | 640 | 487,588 | - | - | 488,228 | |||||||||||||
| Income tax benefits realized from employee stock option exercises | - | - | 264,980 | - | - | 264,980 | |||||||||||||
| Issuance of stock under employee stock plan | 2,796 | 56 | 38,577 | - | - | 38,633 | |||||||||||||
| Repurchase of Common Stock | (11,010 | ) | (218 | ) | (71,553 | ) | (129,574 | ) | - | (201,345 | ) | ||||||||
Balance December 31, 2003 | 1,049,484 | 20,990 | 7,359,416 | (1,157,141 | ) | 297,033 | 6,520,298 | ||||||||||||
| Comprehensive income | |||||||||||||||||||
| Net income | - | - | - | 784,816 | - | 784,816 | |||||||||||||
| Changes in unrealized gain on securities available-for-sale, net of tax | - | - | - | - | 10,789 | 10,789 | |||||||||||||
| Changes in fair value of cash flow hedges, net of tax | - | - | - | - | (16,874 | ) | (16,874 | ) | |||||||||||
| Comprehensive income | 778,731 | ||||||||||||||||||
| Issuance of stock upon exercise of options | 21,484 | 430 | 446,084 | - | �� | - | 446,514 | ||||||||||||
| Income tax benefits realized from employee stock option exercises | - | - | 329,470 | - | - | 329,470 | |||||||||||||
| Issuance of stock under employee stock plan | 1,717 | 34 | 58,826 | - | - | 58,860 | |||||||||||||
| Repurchase of Common Stock | (25,558 | ) | (511 | ) | (191,042 | ) | (1,160,130 | ) | - | (1,351,683 | ) | ||||||||
Balance December 31, 2004 | 1,047,127 | 20,943 | 8,002,754 | (1,532,455 | ) | 290,948 | 6,782,190 | ||||||||||||
| Comprehensive income | |||||||||||||||||||
| Net income | - | - | - | 1,278,991 | - | 1,278,991 | |||||||||||||
| Changes in unrealized loss on securities available-for-sale, net of tax | - | - | - | - | (75,359 | ) | (75,359 | ) | |||||||||||
| Changes in fair value of cash flow hedges, net of tax | - | - | - | - | 37,833 | 37,833 | |||||||||||||
| Comprehensive income | 1,241,465 | ||||||||||||||||||
| Issuance of stock upon exercise of options | 28,823 | 576 | 745,223 | - | - | 745,799 | |||||||||||||
| Income tax benefits realized from employee stock option exercises | - | - | 641,348 | - | - | 641,348 | |||||||||||||
| Issuance of stock under employee stock plan | 1,872 | 37 | 74,657 | - | - | 74,694 | |||||||||||||
| Repurchase of Common Stock | (24,109 | ) | (482 | ) | (201,303 | ) | (1,814,127 | ) | - | (2,015,912 | ) | ||||||||
Balance December 31, 2005 | 1,053,713 | $ | 21,074 | $ | 9,262,679 | $ | (2,067,591 | ) | $ | 253,422 | $ | 7,469,584 | |||||||
| Retained | Accumulated | |||||||||||||||||||||||
| Additional | Earnings | Other | ||||||||||||||||||||||
Common Stock | Paid-in | (Accumulated | Comprehensive | |||||||||||||||||||||
Shares | Amounts | Capital | Deficit) | Income | Total | |||||||||||||||||||
| Balance December 31, 2005 | 1,054 | $ | 21 | $ | 9,263 | $ | (2,067 | ) | $ | 253 | $ | 7,470 | ||||||||||||
| Comprehensive income | ||||||||||||||||||||||||
| Net income | – | – | – | 2,113 | – | 2,113 | ||||||||||||||||||
| Decrease in unrealized gain on securities available-for-sale, net of tax | – | – | – | – | (16 | ) | (16 | ) | ||||||||||||||||
| Changes in fair value of cash flow hedges, net of tax | – | – | – | – | (27 | ) | (27 | ) | ||||||||||||||||
| Change in post-retirement benefit obligation, net of tax | – | – | – | – | (6 | ) | (6 | ) | ||||||||||||||||
| Comprehensive income | 2,064 | |||||||||||||||||||||||
| Issuance of stock upon exercise of options | 9 | – | 288 | – | – | 288 | ||||||||||||||||||
| Income tax benefits realized from employee stock option exercises | – | – | 179 | – | – | 179 | ||||||||||||||||||
| Issuance of stock under employee stock purchase plan | 2 | – | 97 | – | – | 97 | ||||||||||||||||||
| Stock-based compensation expense | – | – | 376 | – | – | 376 | ||||||||||||||||||
| Repurchase of Common Stock | (12 | ) | – | (112 | ) | (884 | ) | – | (996 | ) | ||||||||||||||
| Balance December 31, 2006 | 1,053 | 21 | 10,091 | (838 | ) | 204 | 9,478 | |||||||||||||||||
| Comprehensive income | ||||||||||||||||||||||||
| Net income | – | – | – | 2,769 | – | 2,769 | ||||||||||||||||||
| Increase in unrealized gain on securities available-for-sale, net of tax | – | – | – | – | 5 | 5 | ||||||||||||||||||
| Changes in fair value of cash flow hedges, net of tax | – | – | – | – | (10 | ) | (10 | ) | ||||||||||||||||
| Change in post-retirement benefit obligation, net of tax | – | – | – | – | (2 | ) | (2 | ) | ||||||||||||||||
| Comprehensive income | 2,762 | |||||||||||||||||||||||
| Issuance of stock upon exercise of options | 10 | – | 340 | – | – | 340 | ||||||||||||||||||
| Income tax benefits realized from employee stock option exercises | – | – | 177 | – | – | 177 | ||||||||||||||||||
| Issuance of stock under employee stock purchase plan | 2 | – | 112 | – | – | 112 | ||||||||||||||||||
| Stock-based compensation expense | – | – | 407 | – | – | 407 | ||||||||||||||||||
| Cumulative effect of change in accounting principle | – | – | – | (26 | ) | – | (26 | ) | ||||||||||||||||
| Repurchase of Common Stock | (13 | ) | – | (132 | ) | (913 | ) | – | (1,045 | ) | ||||||||||||||
| Prepaid repurchase of Common Stock | – | – | (300 | ) | – | – | (300 | ) | ||||||||||||||||
| Balance December 31, 2007 | 1,052 | 21 | 10,695 | 992 | 197 | 11,905 | ||||||||||||||||||
| Comprehensive income | ||||||||||||||||||||||||
| Net income | – | – | – | 3,427 | – | 3,427 | ||||||||||||||||||
| Decrease in unrealized gain on securities available-for-sale, net of tax | – | – | – | – | (79 | ) | (79 | ) | ||||||||||||||||
| Changes in fair value of cash flow hedges, net of tax | – | – | – | – | 5 | 5 | ||||||||||||||||||
| Change in post-retirement benefit obligation, net of tax | – | – | – | – | 1 | 1 | ||||||||||||||||||
| Comprehensive income | 3,354 | |||||||||||||||||||||||
| Issuance of stock upon exercise of options | 13 | – | 572 | – | – | 572 | ||||||||||||||||||
| Income tax benefits realized from employee stock option exercises | – | – | 124 | – | – | 124 | ||||||||||||||||||
| Issuance of stock under employee stock purchase plan | 2 | – | 108 | – | – | 108 | ||||||||||||||||||
| Stock-based compensation expense | – | – | 388 | – | – | 388 | ||||||||||||||||||
| Repurchase of Common Stock and settlement of prepaid stock repurchase agreement | (14 | ) | – | 157 | (937 | ) | – | (780 | ) | |||||||||||||||
| Balance December 31, 2008 | 1,053 | $ | 21 | $ | 12,044 | $ | 3,482 | $ | 124 | $ | 15,671 | |||||||||||||
See Notes to Consolidated Financial Statements.
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
In this Annual Report, “Genentech,” “we,” “us”“us,” and “our” refer to Genentech, Inc. “Common Stock” refers to Genentech’s Common Stock, par value $0.02 per share, “Special Common Stock” refers to Genentech’s callable putable Common Stock,common stock, par value $0.02 per share, all of which was redeemed by Roche Holdings, Inc. (or “Roche”)(RHI) on June 30, 1999 (or “the Redemption”)(the Redemption).
Note 1. | DESCRIPTION OF BUSINESS |
Genentech is a leading biotechnology company that discovers, develops, manufactures and commercializes biotherapeuticsmedicines for patients with significant unmet medical needs. We commercialize multiple biotechnology products and also receive royalties from companies that haveare licensed to market products based on our technology.
Redemption of Our Special Common Stock
On June 30, 1999, RocheRHI exercised its option to cause us to redeem all of our Special Common Stock held by stockholders other than Roche.RHI. The Redemption was reflected as a purchase of a business, which under U.S. generally accepted accounting principlesGAAP required push-down accounting to reflect in our financial statements the amounts paid for our stock in excess of our net book value. As a result, we were required to push down the effect of the Redemption and Roche’s 1990 through 1997 purchases of our Common and Special Common Stock into our consolidated financial statements at the date of the Redemption. In 1990 and 1991 through 1997 Roche purchased 60% and 5%, respectively, of the outstanding stock of Genentech. In June 1999, we redeemed all of our Special Common Stock held by stockholders other than Roche resulting in Roche owning 100% of our Common Stock. The push-down effect of Roche’s aggregate purchase price and the Redemption price in our consolidated balance sheet as of June 30, 1999 was allocated based on Roche’s ownership percentages as if the purchases occurred at the original purchase dates for the 1990 and 1991 through 1997 purchases, and at June 30, 1999 for the Redemption. Management of Genentech determined the values of tangible and intangible assets, including in-process research and development used in allocating the purchase prices. The aggregate purchase price for the acquisition of all of Genentech’s outstanding shares, including Roche’sRHI’s estimated transaction costs of $10.0$10 million, was $6,604.9 million, consisting of approximately $2,843.5 million for the 1990 and 1991 through 1997 purchases and approximately $3,761.4 million for the Redemption.$6,605 million.
Note 2. | SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES |
Principles of Consolidation
The consolidated financial statements include the accounts of Genentech and all wholly ownedof our wholly-owned subsidiaries. Genentech also consolidated a variable interest entity in which Genentech was the primary beneficiary pursuant to Financial Accounting Standards Board (or “FASB”) Interpretation No. 46 (or “FIN 46”) “Consolidation of Variable Interest Entities,” as amended, and recorded a noncontrolling interest in “litigation-related and other long-term liabilities,” which has been reflected in the accompanying consolidated balance sheet at December 31, 2004. As discussed below in Note 7, “Leases, Commitments and Contingencies,” in August 2005, we paid $425.0 million to extinguish the debt and the noncontrolling interest related to a synthetic lease obligation on our manufacturing plant in Vacaville, California. Material intercompany accounts and transactions have been eliminated.
Use of Estimates and Reclassifications
The preparation of financial statements in conformity with GAAP requires management to make judgments, assumptions, and estimates that affect the amounts reported in our consolidated financial statements and accompanying notes. Actual results could differ materially from those estimates.
In January 2003,December 2007, the FASB issued FIN 46, and in December 2003 issued FIN 46R, a revision to Interpretation 46, “Consolidation of Variable Interest Entities,” which requires a variable interest entity (or “VIE”) to be consolidated by a company if that company absorbs a majority of the VIE’s expected losses, receives a majority of the entity’s expected residual returns, or both, as a result of ownership, contractual or other financial interest in the VIE.
In December 2007, the FASB issued EITF 07-1, “Accounting for Collaborative Agreements” (EITF 07-1). EITF 07-1 provides guidance regarding financial statement presentation and disclosure of collaborative arrangements, which includes arrangements entered into regarding development and commercialization of products. It requires certain transactions between collaborators to be recorded in the income statement on either a gross or net basis when certain characteristics exist in the collaborative relationship. EITF 07-1 became effective for us on January 1, 2009. The adoption of EITF 07-1 will not have an effect on our financial condition or our net income. However, the adoption of EITF 07-1 may have an effect on the presentation of collaborative arrangements in our income statements and could result in compensation expensethe reporting of lower amounts of contract revenues, R&D expenses, and profit sharing expense.
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In February 2008, the FASB issued Statement of Financial Position (FSP) No. 157-2, which delays the effective date of FAS 157 for non-financial assets and non-financial liabilities, except for items that will reduce diluted net income per share by approximately $0.15are recognized or disclosed at fair value on a recurring basis (items that are remeasured at least annually). The FSP deferred the effective date of FAS 157 for non-financial assets and non-financial liabilities until our fiscal year beginning on January 1, 2009. We do not expect the adoption of FAS 157 for non-financial assets and non-financial liabilities to $0.17 per share for 2006. However,have a material effect on our estimate of future stock-based compensation expense is affected by our stock price, the number of stock-based awards our board of directors may grant in 2006, as well as a number of complex and subjective valuation assumptions and the related tax effect. These valuation assumptions include, but are not limited to, the volatility of our stock price and employee stock option exercise behaviors.consolidated financial statements.
In March 2008, the FASB issued FAS No. 161, “Disclosures about Derivative Instruments and Hedging Activities, an amendment of FASB Statement No. 133” (FAS 161). FAS 161 requires us to provide greater transparency about how and why we use derivative instruments, how the instruments and related hedged items are accounted for under FAS No. 133, “Accounting for Derivative Instruments and Hedging Activities” (FAS 133), and how the instruments and related hedged items affect our financial position, results of operations, and cash flows. FAS 161 became effective for us on January 1, 2009. We do not expect the adoption of FAS 161 to have an effect on our financial condition or results of operations, but we will be required to expand our disclosure regarding our derivative instruments.
Revenue Recognition
We recognize revenue from the sale of our products, royalties earned, and contract arrangements. Our revenue arrangements with multiple elements are divided into separate units of accounting if certain criteria are met, including whether the delivered element has stand-alone value to the customer and whether there is objective and reliable evidence of the fair value of the undelivered items. The consideration we receive is allocated among the separate units based on their respective fair values, and the applicable revenue recognition criteria are applied to each of the separate units. Advance payments received in excess of amounts earned are classified as deferred revenue until earned.
We recognize revenue from product sales when there is persuasive evidence that an arrangement exists, title passes, the price is fixed and determinable, and collectibility is reasonably assured. Allowances are established for estimated rebates, healthcare provider contractual chargebacks, prompt-pay sales discounts, product returns, and wholesaler and distributor inventory management allowances. In our domestic commercial collaboration agreements, we have primary responsibility for U.S. product sales commercialization efforts, including selling and marketing, customer service, order entry, distribution, shipping and billing. We record net product sales and related production and selling costs in our income statement line items on a gross basis, since we have the manufacturing risk and/or inventory risk, and credit risk, and meet the criteria as a principal under EITF 99-19.
We recognize revenue from royalties based on licensees’ sales of our products or products using our technologies. Royalties are recognized as earned in accordance with the contract terms when royalties from licensees can be reasonably estimated and collectibility is reasonably assured. If the collectibility of a royalty amount is not reasonably assured, royalties are recognized as revenue when the cash is received. For the majorityapproximately half of our royalty revenues,revenue, estimates are made using historical and forecasted sales trends and used as a basis to record amounts in advance of amounts collected.
Contract Revenue
Contract revenue generally includes up-front and continuing licensing fees, manufacturing fees, milestone payments and net reimbursements from collaborators on development, post-marketing and commercial costs. Nonrefundable up-front fees, including product opt-ins, for which no further performance obligations exist, are recognized as revenue on the earlier of when payments are received or collection is reasonably assured. Fees associated with substantive milestones, which are contingent upon future events for which there is reasonable uncertainty as to their achievement at the time the agreement was entered into, are recognized as revenue when these milestones, as defined in the contract, are achieved.
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Certain of our revenue arrangements contain multiple deliverables. For those contract arrangements with multiple deliverables that were entered into prior to the effective date of July 1, 2003 for EITF 00-21, “Revenue Arrangements with Multiple Deliverables” (EITF 00-21), our accounting policy on contract revenue is as follows:
| Nonrefundable |
| ratably over the development period if development risk is significant, or |
| ratably over the manufacturing period or estimated product useful life if development risk has been substantially eliminated. |
For those contract arrangements with multiple deliverables that were entered into subsequent to the effective date of July 1, 2003 for EITF 00-21, our accounting policy is as follows:
| Ÿ |
| Ÿ | Rebate allowances and accruals comprise both direct and indirect rebates. Direct rebates are contractual price adjustments payable to wholesalers and specialty pharmacies that purchase products directly from us. Indirect rebates are contractual price adjustments payable to healthcare providers and organizations, such as payers, clinics, hospitals, pharmacies, and group purchasing organizations that do not purchase products directly from us. Both types of allowances are based on definitive contractual agreements or legal requirements (such as Medicaid) related to the dispensing of the product by a pharmacy, clinic, or hospital to a benefit plan participant. Rebate accruals are recorded in the same period that the related revenue is recognized, resulting in a reduction to product sales revenue and the recognition of a contra asset (if due to a wholesaler or specialty pharmacy) or a liability (if due to a third party, such as a healthcare provider) as appropriate, which are included in accounts receivable allowances or other accrued liabilities, respectively. Rebates are estimated using historical and other data, including patient usage, customer buying patterns, applicable contractual rebate rates, and contract performance by the benefit providers. Rebate estimates are evaluated quarterly and may require adjustments to better align our estimates with actual results. As part of this evaluation, we review changes to federal legislation, changes to rebate contracts, changes in the level of discounts, and changes in product sales trends. Although rebates are accrued at the time of sale, rebates are typically paid out, on average, up to six months after the sale. |
| Ÿ | Healthcare provider contractual chargebacks are the result of contractual commitments by us to provide products to healthcare providers at specified prices or discounts. These contracted healthcare providers include (i) hospitals that service a disproportionately high share of economically indigent and Medicaid patients for which they receive little or no reimbursement (i.e., Disproportionate Share Hospitals), (ii) government-owned hospitals that receive discounts, and (iii) hospitals that have contract pricing for certain products, usually through a group purchasing agreement. Chargebacks occur when a contracted healthcare provider purchases our products through an intermediary wholesaler at fixed contract prices that are lower than the list prices we charge the wholesalers. The wholesaler, in turn, charges us back for the difference between the price initially paid by the wholesaler and the contract price paid to the wholesaler by the healthcare providers. Chargebacks are accrued at the time of sale and are estimated based on historical trends, which closely approximate actual results as we generally issue credits within a few weeks of the time of sale. |
| Ÿ | Prompt-pay sales discounts are credits granted to wholesalers for remitting payment on their purchases within contractually defined cash repayment incentive periods. The contractually defined cash repayment periods are generally 30 days; however, for newly launched products, we have offered and we may offer in the future, extended payment terms to wholesalers. In connection with the launch of Lucentis, we have offered, and continue to offer, an extended payment terms program to certain wholesalers. Based upon our experience that it is rare that a wholesaler does not comply with the contractual terms to earn the prompt-pay sales discount, we accrue 100 percent of the prompt-pay sales discounts at the time of original sale. |
| Ÿ | Wholesaler and distributor inventory management allowances are credits granted to wholesalers and distributors for compliance with various contractually defined inventory management programs. These programs provide monetary incentives in the form of a credit for wholesalers and distributors to maintain consistent inventory levels at approximately two to three weeks of sales depending on the product. These wholesaler inventory management credits are calculated based on quarterly product purchases multiplied by a factor to determine the maximum possible credit for a product for the preceding quarter. Adjustments to reduce the maximum credit are made if the wholesaler does not meet and/or comply with the contractually defined metrics. These metrics include data timeliness, completeness and accuracy and deviations outside of the contracted inventory days on hand for each product. The maximum credits are accrued at the time of sale, and are typically granted to wholesaler accounts within 90 days after the sale. |
| Ÿ | Product return allowances are established in accordance with our returns policy, which allows buyers to return our products within two months prior to and six months following product expiration. Most of our products are sold to our wholesalers with at least six months of dating prior to expiration. As part of our estimation process, we calculate historical return data on a production lot basis. Historical rates of return are determined by product and are adjusted for known or expected changes in the marketplace specific to each product. In addition, we review expiration dates to determine the remaining shelf life of each product not yet returned. Although product return allowances are accrued at the time of sale, the majority of returns take place up to two years after the sale. |
Allowances against receivable balances primarily relate to product returns, wholesaler chargebacks,wholesaler-related direct rebates, prompt-pay sales discounts, and bad debts,wholesaler inventory management allowances, and are recorded in the same period that the related revenue is recognized, resulting in a reduction toin product sales revenue and the reporting of product sales receivable net of allowances. We estimate these allowances based primarily on analyses of existingAccruals related to indirect rebates and contractual obligationschargebacks for healthcare providers are recognized in the same period that the related revenue is recognized, resulting in a reduction in product sales revenue, and eligible discounts, historical trends and experience, and changes in financial conditions of our customers.are recorded as other accrued liabilities.
Commercial Collaboration Profit SharingAccounting
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the customer, we have general inventory risk prior to the customer placing an order or upon customer return, and we are exposed to customer credit risk. We record net product sales and related production and selling costs for our domestic collaborations in our Consolidated Statements of Income on a gross basis since we are the principal in the sales transaction as defined under EITF 99-19. The collaboration profit sharing expense line in our Consolidated Statements of Income includes the profit sharing results with Biogen Idec on Rituxan, with Novartis Pharma AG on Xolair, and with OSI Pharmaceuticals on Tarceva.
We have a European commercial collaboration profit sharing agreement with Novartis Pharma AG on Xolair. We do not record the net product sales and related production and selling costs for our European collaboration in our Consolidated Statements of Income on a gross basis since we do not meet the criteria as a principal under EITF 99-19, and instead record our net share of the European collaboration profits as contract revenue (or collaboration losses as collaboration profit sharing expense). See also Note 8,10, “Relationship with Roche Holdings, Inc. and Related Party Transactions,” below regarding Novartis relatedNovartis-related collaboration costcosts and profit sharing expenses.
Research and Development Expenses
Research and development (or "R&D")(R&D) expenses include salaries, benefits, and other headcount related costs,costs; clinical trial and related clinical manufacturing costs,costs; contract and other outside service fees,fees; employee stock-based compensation expense; and facilities and overhead costs. R&D expenses consist of independent R&D costs and costs associated with collaborative R&D and in-licensing arrangements. In addition, we acquire R&D services from other companies and fund research institutions under agreements whichthat we can generally terminate at will. R&D expenses also include post-marketing activities such as Phase IV and investigator-sponsored trials and product registries. R&D costs, including upfrontup-front fees and milestones paid to collaborators, are expensed as incurred.incurred, if the underlying technology and/or intellectual property rights acquired are determined not to have an alternative future use. The costs of the acquisition of technology isare capitalized if it hasthey have alternative future uses in other research and developmentR&D projects or otherwise. R&D collaborations resulting in a net payment of development and post-marketing costs to our collaborators are recognized as R&D expense as the related costs are incurred.
Royalty Expenses
Royalty expenses and milestones directly related to product sales are classified in cost of sales.COS. Other royalty expenses, relatingrelated to royalty revenue, are classified in MG&A expenses and totaled $182.3$379 million in 2005, $174.02008, $312 million in 2004,2007, and $114.3$221 million in 2003.2006.
Advertising Expenses
We expense the costs of advertising, which also includesinclude promotional expenses, as incurred. Advertising expenses were $344.6$371 million in 2005, $257.42008, $400 million in 2004,2007, and $197.8$439 million in 2003.
2006.
Research and Development Arrangements
To gain access to potential new products and technologies and to utilize other companies to help develop our potential new products, we establish strategic alliances with various companies. These strategic alliances often include the acquisition of marketable and nonmarketable equity investments or debt of companies developing technologies that complement or fall outside of our research focus and include companies having the potential to generate new products through technology licensing and/or investments. Potential future payments may be due to certain collaborators achieving certain benchmarks as defined in the collaborative agreements. We also entered into product-specific collaborations to acquire development and marketing rights for products. See Note 7,9, “Leases, Commitments, and Contingencies,” and Note 8,10, “Relationship with Roche Holdings, Inc. and Related Party Transactions,” below for a discussion of our more significant collaborations.
Cash and Cash Equivalents
We consider all highly liquid available-for-sale debt securities purchased with an original maturity of three months or less to be cash equivalents.
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Inventories
Inventories are stated at the lower of cost or market.market value. Cost is determined using a weighted-average approach.approach, assuming full absorption of direct and indirect manufacturing costs, based on normal product capacity utilization assumptions. Excess or idle capacity costs, resulting from utilization below a plant’s normal capacity, are recognized as COS in the period in which they are incurred. If inventory costs exceed expected market value due to obsolescence or lack ofinsufficient forecasted demand, reserves are recorded for the difference between the cost and the estimated market value. These reserves are determined based on significant estimates. Inventories consist ofmay include currently marketed products products manufactured under contract and product candidatesa new process or at facilities awaiting regulatory approval whichlicensure. These inventories are capitalized based on management’sif, in our judgment, at the time of probable near term commercialization.manufacture near-term regulatory licensure is reasonably assured. In addition, inventories include employee stock-based compensation expenses capitalized under FAS 123R and capitalized costs related to the retention plans approved in August 2008.
Investments in Marketable and Nonmarketable Securities
We investhold investments in short-term and long-term marketable securities, consisting primarily of corporate notes,bonds, commercial paper, government agencies, preferred stock, asset-backedand agency securities, municipal bonds and municipal bonds.bonds denominated in foreign currencies but hedged to U.S. dollars. As part of our strategic alliance efforts, we may also invest in equity securities, dividend bearingdividend-bearing convertible preferred stock, and interest-bearing debt of other biotechnology companies. AllWe record these investments under the cost method of our equity investments representaccounting, as we hold less than a 10%20% ownership position in the investee company. Marketable equity and debt securities are accounted for as available-for-sale investments as described below. Nonmarketable equity securities are carried at cost, less any write-downs for impairment. We periodically monitor the liquidity and financing activitiesall of the respective issuers to determine if impairment write downs to our nonmarketable equity securities are necessary.these collaborator companies.
We classify marketable equity and debt securities into one of two categories: available-for-sale or trading. Trading securities are bought, held, and sold with the objective of generating returns from market movements.returns. We have established maximum amounts of our total investment portfolio that can be included in our trading portfolio, the majority of which is managed by investment management firms that operate within investment policy guidelines that we provide. Trading securities are classified as short-term investments and are carried at estimated fair market value. Unrealized holding gains and losses on trading securities are included in "interest“Interest and other income, (expense), net". Securitiesnet.” Debt securities and marketable equity securities not classified as trading are considered available-for-sale. These securities are carried at estimated fair value (see Note 3,4, “Investment Securities and Financial Instruments,” below) with unrealized gains and losses included in accumulated other comprehensive income in stockholders’ equity. Unrealized losses are charged against “Interest and other income, net” when a decline in fair value is determined to be other-than-temporary. We review several factors to determine whether a loss is other-than-temporary. These factors include but are not limited to: (i) the extent to which the fair value is less than cost and the cause for the fair value decline, (ii) the financial condition and near-term prospects of the issuer, (iii) the length of time a security is in an unrealized loss position and (iv) our ability to hold the security for a period of time sufficient to allow for any anticipated recovery in fair value. Available-for-sale equity securities and available-for-sale debt securities with remaining maturities of greater than one year are classified as long-term. If the estimated fair value of a security is below its carrying value, we evaluate whether we have the intent and ability to retain our investment for a period of
Nonmarketable equity securities are carried at cost, less any write-downs for impairment. We periodically monitor the liquidity and financing activities and R&D progress of the respective issuers to determine if impairment write-downs to our nonmarketable equity securities are necessary.
Derivative Instruments
We use derivatives to manage our market exposure to fluctuations in foreign currencies, U.S. interest rates and marketable equity investments. We record all derivatives on the balance sheet at estimated fair value. For derivative instruments that are designated and qualify as a fair value hedge (i.e., hedging the exposure to changes in the
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estimated fair value of an asset or a liability or an identified portion thereof that is attributable to a particular risk), the gain or loss on the derivative instrument, as well as the offsetting loss or gain on the hedged item attributable to the hedged risk, is recognized in current earnings during the period of the change in estimated fair values. For derivative instruments that are designated and qualify as a cash flow hedge (i.e., hedging the exposure to variability in expected future cash flows that is attributable to a particular risk), the effective portion of the gain or loss on the derivative instrument is reported as a component of other comprehensive income and reclassified into earnings in the same period or periods during which the hedged transaction affects earnings. The gain or loss on the derivative instruments in excess of the cumulative change in the present value of future cash flows of the hedged transaction, if any, is recognized in current earnings during the period of change. We do not use derivative instruments for speculative purposes. See Note 3,4, “Investment Securities and Financial Instruments — Instruments—Derivative Financial Instruments”Instruments,” below for further information on our accounting for derivatives.
Property, Plant and Equipment
The costs of buildings and equipment are depreciated using the straight-line method over the estimated useful lives of the assets, but not more than:
Useful Lives | |
| Buildings | 25 years |
| Certain manufacturing equipment | 15 years |
| Other equipment | 3 to 8 years |
| Leasehold improvements |
Depreciation expense on biologics manufacturing facilities constructed or purchased begins once production activities have commenced at the facility, which is generally at the point at which qualification lots are being successfully produced. The costspoint at which depreciation is commenced best represents the point at which the asset is ready for its intended use, and generally precedes FDA licensure of repairs and maintenance are expensed as incurred and were $117.1 million in 2005, $93.3million in 2004, and $65.6 million in 2003.the facility.
FDA validation costs are capitalized as part of the effort required to acquire and construct long-lived assets, including readying them for their intended use, and are amortized over the estimated useful life of the asset or the term of the lease, whichever is shorter, and charged to cost of sales.COS. These costs are included in “other“Other long-term assets” in the accompanying consolidated balance sheets.Consolidated Balance Sheets.
Goodwill and Other Intangible Assets
Goodwill represents the difference between the purchase price and the estimated fair value of the net assets acquired when accounted for by the purchase method of accounting and arises from Roche’sRHI’s purchases of our Special Common Stock and push-down accounting (refer to the “Redemption of Our Special Common Stock” notein Note 1 above). as well as from our acquisition of Tanox in 2007. In accordance with FAS 142, “Goodwill“Goodwill and Intangible Assets” (FAS 142), we do not amortize goodwill. Also in accordance with FAS 142, we perform an annual impairment test of goodwill every September at the Companycompany level, which is
the sole reporting unit, and have found no impairment. We will continue to evaluate our goodwill for impairment annually and whenever events and changes in circumstances suggest that the carrying amount may not be recoverable.
We amortize intangible assets with definite lives on a straight-line basis over their estimated useful lives, ranging from five to 15 years, and review for impairment on a quarterly basis and when events or changes in circumstances indicate that the carrying amount of such assets may not be recoverable. We capitalize costs of patents and patent applications related to products and processes of significant importance to us and amortize these on a straight-line basis over their estimated useful lives of approximately 12 years.
Restricted Cash and Investments
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amounts are reflected in the consolidated balance sheetsConsolidated Balance Sheet in “restricted“Restricted cash and investments” at December 31, 2005investments.” As a result of the April 24, 2008 California Supreme Court decision, we paid $476 million to COH in the second quarter of 2008, reflecting the amount of compensatory damages awarded plus interest thereon from the date of the original decision, June 10, 2002. During the third quarter of 2008, the court completed certain administrative procedures to dismiss the case. As a result, the restrictions were lifted from the restricted cash and 2004. investments accounts, which consisted of available-for-sale investments, and the funds became available for use in our operations. See Note 9, “Leases, Commitments, and Contingencies,” for further discussion of the COH litigation.
Impairment of Long-Lived Assets
Long-lived assets and certain identifiable intangible assets to be held and used are reviewed for impairment when events or changes in circumstances indicate that the carrying amount of such assets may not be recoverable. Determination of recoverability is based on an estimate of undiscounted future cash flows resulting from the use of the asset and its eventual disposition. In the event that such cash flows are not expected to be sufficient to recover the carrying amount of the assets, the assets are written down to their estimated fair values. Long-lived assets and certain identifiable intangible assets to be disposed of are reported at the lower of carrying amount or fair value less cost to sell.
Sabbatical Leave Benefits
On January 1, 2007, we adopted EITF Issue No. 06-2, “Accounting for Sabbatical Leave and Other Similar Benefits Pursuant to FASB Statement No. 43, Accounting for Compensated Absences” (EITF 06-2). Prior to the adoption of EITF 06-2, we recorded a liability for a sabbatical leave when the employee vested in the benefit, which was only at the end of a six-year service period. Under EITF 06-2, we accrue an estimated liability for a sabbatical leave over the requisite six-year service period, as the employee’s services are rendered. Upon our adoption of EITF 06-2, we recorded an adjustment to retained earnings of $26 million, net of tax, as a cumulative effect of a change in accounting principle.
Accounting for Employee Stock-Based Compensation
We will adoptaccount for share-based payment under FAS 123R, aswhich requires the recognition of January 1, 2006. Through December 31, 2005, we have followed APB 25 to account for employee stock options. Under APB 25, the intrinsic value method of accounting, no compensation expense, is recognized because the exercise price of our employee stock options equals the market price of the underlying stock on the date of grant. We apply FAS 123using a fair-value based method, for disclosure purposes only, and recognize compensation expense on a straight-line basis over the vesting period of the award.
2005 | 2004 | 2003 | ||||||||
| Net income as reported | $ | 1,278,991 | $ | 784,816 | $ | 562,527 | ||||
| Deduct: Total stock-based employee compensation expense determined under the fair value based method for all awards, net of related tax effects | 174,597 | 190,375 | 172,045 | |||||||
| Pro forma net income | $ | 1,104,394 | $ | 594,441 | $ | 390,482 | ||||
| Earnings per share: | ||||||||||
| Basic-as reported | $ | 1.21 | $ | 0.74 | $ | 0.54 | ||||
| Basic-pro forma | $ | 1.05 | $ | 0.56 | $ | 0.38 | ||||
| Diluted-as reported | $ | 1.18 | $ | 0.73 | $ | 0.53 | ||||
| Diluted-pro forma | $ | 1.02 | $ | 0.54 | $ | 0.38 | ||||
2005 | 2004 | 2003 | ||||||||
| Risk-free interest rate | 4.2 | % | 3.4 | % | 2.8 | % | ||||
| Dividend yield | 0 | % | 0 | % | 0 | % | ||||
| Expected volatility | 29.3 | % | 33.3 | % | 44.7 | % | ||||
| Expected term (years) | 4.2 | 4.3 | 5.0 | |||||||
401(k) Plan and Other Postretirement Benefits
Our 401(k) Plan (or “the Plan”)(the 401(k) Plan) covers substantially all of our employees. For 2003 and earlier, we matchedWe match a portion of employee contributions, up to a maximum of 4%5% of each employee’s eligible compensation. This match increased to 5% in 2004. The match is effective December 31 of each year and is fully vested when made. Also beginning in 2004,funded concurrently with a participant’s semi-monthly contribution to the 401(k) Plan. Additionally, we contributed annually contribute to every employee’s account 1%2% of his or her eligible compensation, regardless of whether or not the employee actively participates actively in the 401(k) Plan. We provided $45.5recorded expense of $91 million in 2005, $34.12008, $85 million in 2004,2007, and $15.9$68 million in 20032006 for our contributions under the Plan.
In addition, we provide certain postretirement benefits, primarily healthcare related, to employees who meet certain eligibility criteria. In accordance with FAS No. 158, “Employers’ Accounting for Defined Benefit Pension and Other Postretirement Plans–an amendment of FASB Statements No. 87, 88, 106, and 132(R)” (FAS 158), we recognize the funded status of our postretirement benefit plan in the statement of financial position. As of December 31, 20052008 and 2004, the accrued2007, our postretirement benefit costs and theplan was not funded. The accumulated postretirement benefit obligation relatedas of December 31, 2008 and 2007 was $30 million and $27 million, respectively, which was primarily included in “Other long-term liabilities” in the Consolidated Balance Sheets.
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Stock Repurchases
The par value method of accounting is used for our common stock repurchases. The excess of the cost of shares acquired over the par value is allocated to these postretirement benefits were not material.additional paid-in capital with the amounts in excess of the estimated original sales price charged to retained earnings.
Income Taxes
Our income tax provision is based on pretax financial accounting income computed underusing the liability method.method in accordance with FAS No. 109, “Accounting for Income Taxes”. Deferred tax assets and liabilities are determined based on the difference between the financial statement and tax basis of assets and liabilities using enacted tax rates in effect for the year in which the differences are expected to reverse. Significant estimates are required in determining our provisions for income taxes. Some of these estimates are based on interpretations of existing tax laws or regulations. We believe that our estimates are reasonable and that our reserves for income tax relatedtax-related uncertainties are adequate. Various internal and external factors may have favorable or unfavorable effects on our future effective income tax rate. These factors include, but are not limited to, changes in tax laws, regulations, and/or rates,rates; the results of any tax examinations; changing interpretations of existing tax laws or regulations,regulations; changes in estimates of prior years’ items,items; past and future levels of R&D spending,spending; acquisitions; changes in our corporate structure; and changes in overall levels of income before tax.
Effective with the consummation of the second public offering of our Common Stock by RocheRHI on October 26, 1999, we ceased to be a member of the consolidated federal income tax group (and certain consolidated or combined state and local income tax groups) of which RocheRHI is the common parent. Accordingly, our tax sharing agreement with RocheRHI now pertains only to the state and local tax returns in which we are consolidated or combined with Roche.RHI. We will continue to calculate our tax liability or refund with RocheRHI for these state and local jurisdictions as if we were a stand-alone entity.
On January 1, 2007, we adopted the provisions of FIN 48. Implementation of FIN 48 did not result in a cumulative adjustment to retained earnings. The total amount of unrecognized tax benefits as of the date of adoption was $147 million. Of this total, $112 million represents the amount of unrecognized tax benefits that, if recognized, would favorably affect our effective income tax rate in any future period. See Note 13, “Income Taxes,” for further discussion of FIN 48.
Earnings Per Share
Basic earnings per share (EPS) are computed based on the weighted-average number of shares of our Common Stock outstanding. Diluted earnings per share areEPS is computed based on the weighted-average number of shares of our Common Stock and other dilutive securities.
The following is a reconciliation of the numerators and denominators of the basic and diluted earnings per shareEPS computations (in thousands)millions):
2005 | 2004 | 2003 | ||||||||
Numerator: | ||||||||||
| Net income | $ | 1,278,991 | $ | 784,816 | $ | 562,527 | ||||
Denominator: | ||||||||||
| Weighted-average shares outstanding used to compute basic earnings per share | 1,054,952 | 1,055,165 | 1,034,480 | |||||||
| Effect of dilutive stock options | 25,997 | 24,044 | 23,139 | |||||||
| Weighted-average shares outstanding and dilutive securities used to compute diluted earnings per share | 1,080,949 | 1,079,209 | 1,057,619 | |||||||
2008 | 2007 | 2006 | ||||||||||
| Numerator: | ||||||||||||
| Net income | $ | 3,427 | $ | 2,769 | $ | 2,113 | ||||||
| Denominator: | ||||||||||||
| Weighted-average shares outstanding used to compute basic EPS | 1,053 | 1,053 | 1,053 | |||||||||
| Effect of dilutive stock options | 14 | 16 | 20 | |||||||||
| Weighted-average shares outstanding and dilutive securities used to compute diluted EPS | 1,067 | 1,069 | 1,073 | |||||||||
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2005 | 2004 | ||
| Number of shares | 18.3 | 19.3 | |
| Range of exercise price | $81.15 - $98.80 | $52.00 - $59.61 |
Comprehensive Income
Comprehensive income is comprised ofcomprises net income and other comprehensive income (or “OCI”)(OCI). OCI includes certain changes in stockholders’ equity that are excluded from net income. Specifically, we include in OCI changes in the estimated fair value of derivatives designated as effective cash flow hedges, and unrealized gains and losses on our available-for-sale securities.securities, and gains or losses and prior service costs or credits that arise during the period but are not recognized as components of net periodic benefit cost. Comprehensive income for the years ended December 31, 2005, 20042008, 2007, and 20032006 has been reflected in the consolidated statementsConsolidated Statements of stockholders’ equity.Stockholders’ Equity.
The components of accumulated other comprehensive income, net of taxes, at December 31, 20052008 and 20042007 were as follows (in millions):
2005 | 2004 | ||||||
| Net unrealized gains on securities available-for-sale | $ | 229.8 | $ | 305.1 | |||
| Net unrealized gains (losses) on cash flow hedges | 23.6 | (14.2 | ) | ||||
| Accumulated other comprehensive income | $ | 253.4 | $ | 290.9 | |||
2008 | 2007 | |||||||
| Net unrealized gains on securities available-for-sale | $ | 140 | $ | 219 | ||||
| Net unrealized losses on cash flow hedges | (9 | ) | (14 | ) | ||||
| Change in post-retirement benefit obligation | (7 | ) | (8 | ) | ||||
| Accumulated other comprehensive income | $ | 124 | $ | 197 | ||||
The activity in OCI related to our available-for-sale securities and cash flow hedges werewas as follows (in millions):
2005 | 2004 | 2003 | ||||||||
| (Decrease) increase in unrealized gains on securities available-for-sale (net of tax: 2005-$(49.1); 2004-$6.7; 2003-$25.9) | $ | (73.6 | ) | $ | 10.0 | $ | 38.9 | |||
| Reclassification adjustment for net (gains) losses on securities available-for-sale included in net income (net of tax: 2005-$(1.1); 2004-$0.5; 2003-($6.5)) | (1.7 | ) | 0.8 | (9.7 | ) | |||||
| Increase (decrease) in unrealized gains on cash flow hedges (net of tax: 2005-$32.3; 2004-($13.8), 2003-($2.4)) | 48.4 | (20.7 | ) | (3.6 | ) | |||||
| Reclassification adjustment for net (gains) losses on cash flow hedges included in net income (net of tax: 2005-$(7.0); 2004-$2.6, 2003-$1.8) | (10.6 | ) | 3.8 | 2.7 | ||||||
| Other comprehensive (loss) income | $ | (37.5 | ) | $ | (6.1 | ) | $ | 28.3 | ||
2008 | 2007 | 2006 | ||||||||||
| Decrease in unrealized gains on securities available-for-sale (net of tax: 2008-$(59); 2007-$(7); 2006-$(11)) | $ | (83 | ) | $ | (10 | ) | $ | (13 | ) | |||
| Reclassification adjustment for net losses (gains) on securities available-for-sale included in net income (net of tax: 2008-$3; 2007-$10; 2006-$(2)) | 4 | 15 | (3 | ) | ||||||||
| Decrease in unrealized gains on cash flow hedges (net of tax: 2008-$(17); 2007-$(8); 2006-$(12)) | (26 | ) | (12 | ) | (18 | ) | ||||||
| Reclassification adjustment for net losses (gains) on cash flow hedges included in net income (net of tax: 2008-$20; 2007-$2; 2006-$(6)) | 31 | 2 | (9 | ) | ||||||||
| Change in post-retirement benefit obligation (net of tax: 2008-$0; 2007-$(1); 2006-$(4)) | 1 | (2 | ) | (6 | ) | |||||||
| Other comprehensive loss | $ | (73 | ) | $ | (7 | ) | $ | (49 | ) | |||
Note 3. | RETENTION PLANS AND EMPLOYEE STOCK-BASED COMPENSATION |
Retention Plan Costs
On July 21, 2008, we announced that we received an unsolicited proposal from Roche to acquire all of the outstanding shares of our Common Stock not owned by Roche at a price of $89 in cash per share (the Roche Proposal). On February 9, 2009, Roche commenced the Roche Tender Offer which replaced the Roche Proposal that was announced on July 21, 2008. See also Note 10, “Relationship with Roche Holdings, Inc. and Related Party Transactions,” for more information on the Roche Proposal and the Roche Tender Offer. On August 18, 2008, we announced that the Special Committee approved the implementation of two retention plans that together cover substantially all employees of the company. The plans are estimated to cost approximately $375 million, payable in cash, and were implemented in lieu of our 2008 annual stock option grant. The timing of the payments related to these plans will depend on the outcome of the Roche Tender Offer or any other tender offer or other proposal by Roche to acquire all of the outstanding shares of our Common Stock not owned by Roche. If a merger of Genentech
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with Roche or an affiliate of Roche has not occurred on or before June 30, 2009, we will pay the retention bonus at that time in accordance with the terms of the plans. We are currently recognizing the retention plan costs in our financial statements ratably over the period from August 18, 2008 to June 30, 2009. If a merger of Genentech with Roche or an affiliate of Roche has occurred on or before June 30, 2009, the timing of the payments and the recognition of the expense will depend on the terms of the merger.
Retention plan costs were as follows (in millions, except per share data):
2008 | ||||
| Research and development | $ | 66 | ||
| Marketing, general and administrative | 69 | |||
| Total retention plan costs | $ | 135 | ||
In 2008, an additional $27 million of retention plan costs were capitalized into inventory, which will be recognized as COS as products that were manufactured after the initiation of the retention plans are estimated to be sold.
Employee Stock Plans
Our ESPP was adopted in 1991 and amended thereafter. The ESPP allows eligible employees to purchase Common Stock at 85% of the lower of the fair market value of the Common Stock on the grant date or the fair market value on the purchase date. The offering period under the ESPP is currently 15 months, and the purchase price is established during each new offering period. Purchases are limited to 15% of each employee’s eligible compensation and subject to certain IRS restrictions. In general, all of our regular full-time employees are eligible to participate in the ESPP. Of the 62,400,000 shares of Common Stock reserved for issuance under the ESPP, 50,501,542 shares have been issued as of December 31, 2008.
We currently grant options under the Genentech, Inc. 2004 Equity Incentive Plan, which allows for the granting of non-qualified stock options, incentive stock options and stock appreciation rights, restricted stock, performance units or performance shares to our employees, directors and consultants. Incentive stock options may only be granted to employees under this plan. Generally, stock options granted to employees have a maximum term of 10 years, and vest over a four year period from the date of grant; 25% vest at the end of one year, and 75% vest monthly over the remaining three years. We may grant options with different vesting terms from time to time. Unless an employee’s termination of service is due to retirement, disability, or death, upon termination of service, any unexercised vested options will be forfeited at the end of three months or the expiration of the option, whichever is earlier.
Stock-Based Compensation Expense under FAS 123R
Employee stock-based compensation expense was calculated based on awards ultimately expected to vest and has been reduced for estimated forfeitures. FAS 123R requires forfeitures to be estimated at the time of grant and revised, if necessary, in subsequent periods if actual forfeitures differ from those estimates.
Employee stock-based compensation expense recognized under FAS 123R was as follows (in millions, except per share data):
2008 | 2007 | 2006 | ||||||||||
| Cost of sales | $ | 82 | $ | 71 | $ | – | ||||||
| Research and development | 152 | 153 | 140 | |||||||||
| Marketing, general and administrative | 165 | 179 | 169 | |||||||||
| Total employee stock-based compensation expense | 399 | 403 | 309 | |||||||||
| Tax benefit related to employee stock-based compensation expense | (137 | ) | (143 | ) | (127 | ) | ||||||
| Net effect on net income | $ | 262 | $ | 260 | $ | 182 | ||||||
Substantially all of the products sold during 2006 were manufactured in previous periods when we did not include employee stock-based compensation expense in our production costs.
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The following pro forma net income and EPS were determined as if we had accounted for employee stock-based compensation expense for our employee stock plans under the fair value method prescribed by FAS 123 prior to 2006 and had capitalized certain costs into inventory manufactured in those prior periods, with the resulting effect on COS for 2006 when previously manufactured products were sold. (In millions, except per share data):
2006 | ||||
| Net income as reported | $ | 2,113 | ||
| Deduct: Total employee stock-based compensation expense includable in cost of sales, net of related tax effects | (34 | ) | ||
| Pro forma net income | $ | 2,079 | ||
| Earnings per share: | ||||
| Basic—as reported | $ | 2.01 | ||
| Basic—pro forma | $ | 1.97 | ||
| Diluted—as reported | $ | 1.97 | ||
| Diluted—pro forma | $ | 1.94 | ||
As of December 31, 2008, total compensation cost related to unvested stock options not yet recognized was $499 million, which is expected to be allocated to expense and production costs over a weighted-average period of 26 months.
Valuation Assumptions
The employee stock-based compensation expense recognized under FAS 123R and presented in the pro forma disclosure required under FAS 123 was determined using the Black-Scholes option valuation model. Option valuation models require the input of subjective assumptions and these assumptions can vary over time. The weighted-average assumptions used are as follows:
2008 | 2007 | 2006 | ||||||||||
| Risk-free interest rate | 2.8 | % | 4.3 | % | 4.6 | % | ||||||
| Dividend yield | 0.0 | % | 0.0 | % | 0.0 | % | ||||||
| Expected volatility | 24.1 | % | 25.1 | % | 27.2 | % | ||||||
| Expected term (years) | 5.0 | 5.0 | 4.6 | |||||||||
Due to the redemption of our Special Common Stock in June 1999 by RHI, there is limited historical information available to support our estimate of certain assumptions required to value our employee stock options as an option grant cycle lasts ten years. In developing our estimate of expected term, we have assumed that our recent historical stock option exercise experience is a relevant indicator of future exercise patterns. We base our determination of expected volatility predominantly on the implied volatility of our traded options with consideration of our historical volatilities and the volatilities of comparable companies.
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Stock Option Activity
The following is a summary of option activity (shares in millions):
Options Outstanding | ||||||||||||
Shares Available for Grant | Number of Shares | Weighted-Average Exercise Price | ||||||||||
| December 31, 2005 | 84 | 83 | $ | 46.64 | ||||||||
| Grants | (17 | ) | 17 | 79.85 | ||||||||
| Exercises | – | (9 | ) | 30.42 | ||||||||
| Cancellations | 3 | (3 | ) | 62.09 | ||||||||
| December 31, 2006 | 70 | 88 | 54.53 | |||||||||
| Grants | (18 | ) | 18 | 79.40 | ||||||||
| Exercises | – | (10 | ) | 32.76 | ||||||||
| Cancellations | 4 | (4 | ) | 76.45 | ||||||||
| December 31, 2007 | 56 | 92 | 60.94 | |||||||||
| Grants | (1 | ) | 1 | 79.23 | ||||||||
| Exercises | – | (13 | ) | 44.83 | ||||||||
| Cancellations | 3 | (3 | ) | 80.52 | ||||||||
| December 31, 2008 | 58 | 77 | $ | 63.06 | ||||||||
The intrinsic value of options exercised during 2008, 2007, and 2006 was $514 million, $501 million, and $500 million, respectively. The estimated fair value of shares vested during 2008, 2007, and 2006, was $388 million, $407 million, and $376 million, respectively. The weighted-average estimated fair value of stock options granted during 2008, 2007, and 2006 was $21.19, $24.40, and $24.95 per option, respectively, based on the assumptions in the Black-Scholes valuation model discussed above.
The following table summarizes outstanding and exercisable options at December 31, 2008 (in millions, except exercise price data):
Options Outstanding | Options Exercisable | |||||||||||||||||||||||||
Range of Exercise Prices | Number of Shares Outstanding | Weighted-Average Remaining Contractual Life (in years) | Weighted-Average Exercise Price | Number of Shares Exercisable | Weighted-Average Remaining Contractual Life (in years) | Weighted-Average Exercise Price | ||||||||||||||||||||
| $6.27 - $8.89 | 0.2 | 6.39 | $ | 6.81 | 0.2 | 6.39 | $ | 6.81 | ||||||||||||||||||
| $10.00 - $14.35 | 6.2 | 2.85 | $ | 13.68 | 6.2 | 2.85 | $ | 13.68 | ||||||||||||||||||
| $15.04 - $22.39 | 4.5 | 2.35 | $ | 20.89 | 4.5 | 2.35 | $ | 20.89 | ||||||||||||||||||
| $22.88 - $33.00 | 0.1 | 2.52 | $ | 26.08 | 0.1 | 2.52 | $ | 26.08 | ||||||||||||||||||
| $35.63 - $53.23 | 20.3 | 4.76 | $ | 47.11 | 20.3 | 4.76 | $ | 47.11 | ||||||||||||||||||
| $53.95 - $75.90 | 2.0 | 7.85 | $ | 68.03 | 0.9 | 6.56 | $ | 63.31 | ||||||||||||||||||
| $75.99 - $82.79 | 29.4 | 8.21 | $ | 79.48 | 12.6 | 8.06 | $ | 79.49 | ||||||||||||||||||
| $83.02 - $98.80 | 14.7 | 6.82 | $ | 86.38 | 11.2 | 6.77 | $ | 86.28 | ||||||||||||||||||
| 77.4 | 56.0 | |||||||||||||||||||||||||
At December 31, 2008, the aggregate intrinsic value of the outstanding options was $1,588 million, and the aggregate intrinsic value of the exercisable options was $1,518 million.
Stock Repurchase Program
Under a stock repurchase program approved by our Board of Directors in December 2003 and most recently extended in April 2008, we are authorized to repurchase up to 150 million shares of our Common Stock for an aggregate amount of up to $10.0 billion through June 30, 2009. During 2008, we repurchased approximately nine
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million shares at an aggregate cost of $780 million. In addition, approximately four million shares were delivered to us on March 31, 2008 in connection with a $300 million prepaid share repurchase arrangement that we entered into with an investment bank in November 2007. Since the program’s inception, we have repurchased approximately 89 million shares at a total price of $6.5 billion. We intend to use the repurchased stock to offset dilution caused by the issuance of shares in connection with our employee stock plans and also to maintain RHI’s minimum percentage ownership interest in our stock. See Note 10, “Relationship with Roche Holdings, Inc. and Related Party Transactions,” for further discussion about RHI’s minimum percentage ownership interest in our stock. See also Note 12, “Capital Stock,” for further discussion of our stock repurchase program.
| Note 4. | INVESTMENT SECURITIES AND FINANCIAL INSTRUMENTS |
Investment Securities
Securities classified as trading and available-for-sale at December 31, 20052008 and 20042007 are summarized below (in thousands)millions). Estimated fair value is based on quoted market prices for thesethe same or similar investments.
December 31, 2005 | Amortized Cost | Gross Unrealized Gains | Gross Unrealized Losses | Estimated Fair Value | |||||||||
| TOTAL TRADING SECURITIES | $ | 614,620 | $ | 11,439 | $ | (13,605 | ) | $ | 612,454 | ||||
| SECURITIES AVAILABLE-FOR-SALE | |||||||||||||
| Equity securities | $ | (2,670 | ) | $ | 380,761 | $ | (3,280 | ) | $ | 374,811 | |||
| Preferred stock | 200,800 | 8,098 | (2,534 | ) | 206,364 | ||||||||
| Debt securities maturing: | |||||||||||||
| within 1 year | 1,616,114 | 238 | (1,152 | ) | 1,615,200 | ||||||||
| between 1-5 years | 1,194,628 | 4,283 | (3,857 | ) | 1,195,054 | ||||||||
| between 5-10 years | 466,874 | 7,083 | (5,224 | ) | 468,733 | ||||||||
| TOTAL SECURITIES AVAILABLE-FOR-SALE | $ | 3,475,746 | $ | 400,463 | $ | (16,047 | ) | $ | 3,860,162 | ||||
| December 31, 2008 | Amortized Cost | Gross Unrealized Gains | Gross Unrealized Losses | Estimated Fair Value | ||||||||||||
| Total trading securities | $ | 889 | $ | 13 | $ | (105 | ) | $ | 797 | |||||||
| Securities available-for-sale: | ||||||||||||||||
| Equity securities | $ | 31 | $ | 257 | $ | (1 | ) | $ | 287 | |||||||
| Preferred stock | 30 | – | (7 | ) | 23 | |||||||||||
| Debt securities maturing: | ||||||||||||||||
| within 1 year | 3,118 | 1 | (5 | ) | 3,114 | |||||||||||
| between 1-5 years | 2,437 | 32 | (26 | ) | 2,443 | |||||||||||
| between 5-10 years | 632 | 20 | (35 | ) | 617 | |||||||||||
| Total securities available-for-sale | $ | 6,248 | $ | 310 | $ | (74 | ) | $ | 6,484 | |||||||
December 31, 2004 | Amortized Cost | Gross Unrealized Gains | Gross Unrealized Losses | Estimated Fair Value | |||||||||
| TOTAL TRADING SECURITIES | $ | 574,907 | $ | 31,261 | $ | (11,123 | ) | $ | 595,045 | ||||
| SECURITIES AVAILABLE-FOR-SALE | |||||||||||||
| Equity securities | $ | 57,993 | $ | 478,226 | $ | (64 | ) | $ | 536,155 | ||||
| Preferred stock | 185,223 | 13,223 | (1,906 | ) | 196,540 | ||||||||
| Debt securities | 1,889,878 | 26,142 | (5,617 | ) | 1,910,403 | ||||||||
| TOTAL SECURITIES AVAILABLE-FOR-SALE | $ | 2,133,094 | $ | 517,591 | $ | (7,587 | ) | $ | 2,643,098 | ||||
| December 31, 2007 | Amortized Cost | Gross Unrealized Gains | Gross Unrealized Losses | Estimated Fair Value | ||||||||||||
| Total trading securities | $ | 984 | $ | 30 | $ | (13 | ) | $ | 1,001 | |||||||
| Securities available-for-sale: | ||||||||||||||||
| Equity securities | $ | 33 | $ | 389 | $ | (6 | ) | $ | 416 | |||||||
| Preferred stock | 162 | 1 | (24 | ) | 139 | |||||||||||
| Debt securities maturing: | ||||||||||||||||
| within 1 year | 1,171 | – | (1 | ) | 1,170 | |||||||||||
| between 1-5 years | 1,886 | 15 | (11 | ) | 1,890 | |||||||||||
| between 5-10 years | 521 | 12 | (3 | ) | 530 | |||||||||||
| Total securities available-for-sale | $ | 3,773 | $ | 417 | $ | (45 | ) | $ | 4,145 | |||||||
The gain or loss on derivative instruments designated as fair value hedges, as well as the offsetting loss or gain on the corresponding hedged marketable equity investment, is recognized currently in earnings. As a result, the cost basis of our equity securities in the table above includes adjustments related to gains and losses on fair value hedges.
Unrealized loss positions for which other-than-temporary impairments have not been recognized at December 31, 20052008 and 2004, is2007 are summarized below (in thousands)millions):
Less Than 12 Months | 12 Months or Greater | Total | |||||||||||||||||
| December 31, 2005 | Fair Value | Unrealized Losses | Fair Value | Unrealized Losses | Fair Value | Unrealized Losses | |||||||||||||
| Equity securities | $ | 6,525 | $ | (3,280 | ) | $ | - | $ | - | $ | 6,525 | $ | (3,280 | ) | |||||
| Preferred stock | 33,773 | (619 | ) | 40,577 | (1,915 | ) | 74,350 | (2,534 | ) | ||||||||||
| Debt securities | 846,469 | (4,703 | ) | 221,118 | (5,530 | ) | 1,067,587 | (10,233 | ) | ||||||||||
| Total | $ | 886,767 | $ | (8,602 | ) | $ | 261,695 | $ | (7,445 | ) | $ | 1,148,462 | $ | (16,047 | ) | ||||
Less Than 12 Months | 12 Months or Greater | Total | ||||||||||||||||||||||
| December 31, 2008 | Fair Value | Unrealized Losses | Fair Value | Unrealized Losses | Fair Value | Unrealized Losses | ||||||||||||||||||
| Equity securities | $ | 4 | $ | (1 | ) | $ | – | $ | – | $ | 4 | $ | (1 | ) | ||||||||||
| Preferred stock | 1 | (2 | ) | 14 | (5 | ) | 15 | (7 | ) | |||||||||||||||
| Debt securities | 1,164 | (39 | ) | 422 | (27 | ) | 1,586 | (66 | ) | |||||||||||||||
| Total | $ | 1,169 | $ | (42 | ) | $ | 436 | $ | (32 | ) | $ | 1,605 | $ | (74 | ) | |||||||||
Less Than 12 Months | 12 Months or Greater | Total | |||||||||||||||||
| December 31, 2004 | Fair Value | Unrealized Losses | Fair Value | Unrealized Losses | Fair Value | Unrealized Losses | |||||||||||||
| Equity securities | $ | 286 | $ | (64 | ) | $ | - | $ | - | $ | 286 | $ | (64 | ) | |||||
| Preferred stock | 27,582 | (1,478 | ) | 11,427 | (428 | ) | 39,009 | (1,906 | ) | ||||||||||
| Debt securities | 603,736 | (3,816 | ) | 78,983 | (1,801 | ) | 682,719 | (5,617 | ) | ||||||||||
| Total | $ | 631,604 | $ | (5,358 | ) | $ | 90,410 | $ | (2,229 | ) | $ | 722,014 | $ | (7,587 | ) | ||||
Less Than 12 Months | 12 Months or Greater | Total | ||||||||||||||||||||||
| December 31, 2007 | Fair Value | Unrealized Losses | Fair Value | Unrealized Losses | Fair Value | Unrealized Losses | ||||||||||||||||||
| Equity securities | $ | 20 | $ | (6 | ) | $ | – | $ | – | $ | 20 | $ | (6 | ) | ||||||||||
| Preferred stock | 86 | (18 | ) | 24 | (6 | ) | 110 | (24 | ) | |||||||||||||||
| Debt securities | 1,004 | (12 | ) | 182 | (3 | ) | 1,186 | (15 | ) | |||||||||||||||
| Total | $ | 1,110 | $ | (36 | ) | $ | 206 | $ | (9 | ) | $ | 1,316 | $ | (45 | ) | |||||||||
Unrealized losses in the portfolio relate to investment-grade preferred securitiesstock and various debt securities portfolios were related to various securities, including corporate bonds, U.S. government agency bonds, municipal bonds corporate bonds,and asset-backed securities, and U.S. government agency bonds.investment-grade preferred securities. For these securities, the unrealized losses are primarily due to increasesthe increase in overall interest rates.rates including fixed income credit spreads. Because we have the ability and intent to hold these investments until a forecasted recovery of fair value, which may be maturity or call date, we do not consider these investments to be other-than-temporarily impaired as of December 31, 2005.2008. See Note 2, “Summary of Significant Accounting Policies — Policies—Investments in Marketable and Nonmarketable Securities,” for further discussion of the criteria used to determine impairment of our equity and fixed income securities.
The carrying amount, which approximates fair value, of all cash, cash equivalents and investment securities held at December 31, 20052008 and 20042007 (see sections "Cash“Cash and Cash Equivalents"Equivalents” and "Investments“Investments in Marketable and Nonmarketable Securities"Securities” in Note 2, "Summary“Summary of Significant Accounting Policies"Policies”) is summarized below (in thousands)millions):
Security | 2005 | 2004 | |||||
| Cash | $ | 75,762 | $ | 207,776 | |||
| Cash equivalents | 1,149,749 | 62,347 | |||||
| Total cash and cash equivalents | $ | 1,225,511 | $ | 270,123 | |||
| Trading securities | $ | 612,454 | $ | 595,045 | |||
| Securities available-for-sale maturing within one year | 320,832 | 603,397 | |||||
| Preferred stock | 206,364 | 196,540 | |||||
| Total short-term investments | $ | 1,139,650 | $ | 1,394,982 | |||
| Securities available-for-sale maturing after one year | $ | 1,073,920 | $ | 579,172 | |||
| Equity securities | 374,811 | 536,155 | |||||
| Total long-term marketable debt and equity securities | $ | 1,448,731 | $ | 1,115,327 | |||
| Cash | $ | 514 | $ | 2,268 | |||
| Securities available-for-sale maturing within one year | 144,619 | 212,368 | |||||
| Securities available-for-sale maturing between 1-10 years | 589,867 | 467,364 | |||||
| Total restricted cash and investments | $ | 735,000 | $ | 682,000 | |||
| Security | 2008 | 2007 | ||||||
| Cash | $ | 2,264 | $ | 1,706 | ||||
| Cash equivalents | 2,269 | 808 | ||||||
| Total cash and cash equivalents | $ | 4,533 | $ | 2,514 | ||||
| Trading securities | $ | 797 | $ | 1,001 | ||||
| Securities available-for-sale maturing within one year | 845 | 321 | ||||||
| Preferred stock | 23 | 139 | ||||||
| Total short-term investments | $ | 1,665 | $ | 1,461 | ||||
| Securities available-for-sale maturing after one year | $ | 3,060 | $ | 1,674 | ||||
| Equity securities | 287 | 416 | ||||||
| Total long-term marketable debt and equity securities | $ | 3,347 | $ | 2,090 | ||||
| Cash | $ | – | $ | 1 | ||||
| Securities available-for-sale maturing within one year | – | 41 | ||||||
| Securities available-for-sale maturing between 1-10 years | – | 746 | ||||||
| Total restricted cash and investments | $ | – | $ | 788 | ||||
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In 2005,2008, proceeds from the sales and maturities of available-for-sale securities totaled $721.7 million; gross$2.0 billion. Gross realized gains totaled $5.9$118 million and gross realized losses totaled $3.1$63 million. In 2004,2007, proceeds from the sales and maturities of available-for-sale securities totaled $1,149.1 million; gross$1.1 billion, of which $300 million was reinvested in our trading securities. Gross realized gains totaled $12.6$26 million and gross realized losses totaled $1.8$8 million. In 2003,2006, proceeds from the sales and maturities of available-for-sale securities totaled $739.9 million;$613 million and gross realized gains totaled $20.6 million and gross realized losses totaled $3.1$61 million.
Net change in unrealized holding (losses) gains on trading securities included in net income totaled ($22.3)$(109) million in 2005, ($17.9)2008, $15 million in 2004,2007, and $18.9$5 million in 2003.2006.
The marketable debt securities that we hold are issued by a diversified selection of corporate and financial institutions with strong credit ratings. Our investment policy limits the amount of credit exposure with any one institution. Other than asset-backed and mortgage-backed securities, these debt securities are generally not collateralized. In 2005, 2004,2008, we recorded a $67 million impairment charge on certain U.S. government agency and 2003,financial institution securities. In 2007, we recorded a $30 million impairment charge to reduce the carrying value of a fixed income investment. In 2006, there were no charges for credit impairment on marketable debt securities.
Our nonmarketable investment securities were $29.4 million at December 31, 2005 and $34.1 million at December 31, 2004, and were based uponon cost less write-downs for impairments, which approximates fair value. Our nonmarketable investment securities were $32 million at December 31, 2008 and $31 million at December 31, 2007, and are classified as other“Other long-term assetsassets” on our consolidated balance sheets.Consolidated Balance Sheets.
Derivative Financial Instruments
Foreign Currency Instruments
We have an established foreign currency hedging program to protect against currency risks, primarily driven by forecasted foreign currency denominatedforeign-currency-denominated royalties from licensees’ product sales over a five yearfive-year period. Other foreign currency exposures include collaboration development expenses. We hedge portions of our forecasted foreign currency revenuesrevenue with optionforward contracts or forward contracts.options, including collars. When the dollar strengthens significantly against the foreign currencies, the decline in value of future foreign currency revenuesrevenue or expenses is offset by gains or losses, respectively, in the value of the option or forward contracts designated as hedges. Conversely, when the dollar weakens, the increase in the value of future foreign currency revenuesrevenue or expenses is offset by losses or gains, respectively, in the value of the forward contracts. In accordance with FAS 133, hedges related to anticipated transactions are designated and documented at the hedge’s inception as cash flow hedges and evaluated for hedge effectiveness at least quarterly.
During the years ended December 31, 2005, 2004,2008, 2007, and 2003,2006, we had no material amounts of ineffectiveness with respect to our foreign currency hedging instruments. Gains and losses related to option and forward contracts that hedge future cash flows are recorded against the hedged revenues or expensesclassified in the consolidated statementssame manner as the underlying hedged transaction in the Consolidated Statements of income.Income.
At December 31, 2005,2008, net gainslosses on derivative instruments expected to be reclassified from accumulated other comprehensive income to earnings during the next twelve12 months due to the receipt of the related net revenuesrevenue denominated in foreign currencies were $21.7$33 million.
Interest Rate Swaps
In July 2005, we entered into a series of interest-rateinterest rate swap agreements with a total notional value of $500.0$500 million to protect the 4.40% Senior Notes due 2010 against changes in estimated fair value due to changes in U.S. interest rates. In these swaps, we pay a floating rate and receive a fixed rate that matches the coupon rate of the 5 yearfive-year Notes due in 2010. See also Note 6, “Long-Term Debt”8, “Debt” below.
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Equity Instruments
Our marketable equity securities portfolio consists primarily of investments in biotechnology companies whose risk of market fluctuations is greater than the stock market in general. To manage a portion of this risk, we enter into derivative instruments such as zero-cost collar instruments and equity forward contracts to hedge equity securities against changes in market value. We have zero-cost collars that expire in 2006 through 2007 and may require settlement in equity securities. A zero-cost collar is a purchased put option and a written call option on a specific equity security such that the cost of the purchased put and the proceeds of the written call offset each other; therefore, there is no initial cost or cash outflow for these instruments. At December 31, 2005, ourOur zero-cost collars were designated and qualified as cash flow hedges.expired in 2007.
As part of our fair value hedging strategy, we have also entered into equity forward contracts that mature in 2006 through 2008.2009. An equity forward is a derivative instrument wherein which we pay the counterparty the total return of the
security above the current spot price and receive interest income on the notional amount for the term of the equity forward. A forward contract is a derivative instrument wherein which we lock-inlock in the termination price that we receive from the sale of stock based on a pre-determined spot price. The forward contract protects us from a decline in the market value of the security below the spot price and limits our potential benefit from an increase in the market value of the security above the spot price. Throughout the life of the contract, we receive interest income based on the notional amount and a floating-rate index.
During the years ended December 31, 2005, 2004,2008, 2007, and 2003,2006, we had no material amounts of ineffectiveness with respect to our zero-cost collarequity hedging instruments. Gains and losses related to zero-cost collar instruments that hedge future cash flows are recorded against the gains or losses from the sale of the underlying hedged marketable equity investment in the consolidated statementsConsolidated Statements of income.
As part of our hedging transactions, we have entered, and may in the future enter, into security lending agreements with our counterparties. For an equity forward contract, in exchange for lending the hedged shares to the counterparty, we receive additional interest income throughout the life of the agreement based on the notional amount and a floating-rate index. For an equity collar, the benefit is embedded in the call strike price. The total estimated fair value of the securities lent under these agreements was $137.6$167 million at December 31, 20052008 and $196.4$161 million at December 31, 2004.2007.
Estimated Fair Value
The estimated fair value of the foreign exchange put optionoptions and forwardforwards was based on the forward exchange rates as of December 31, 20052008 and 2004.2007. The estimated fair value of the equity forward contracts and zero-cost collar instruments was determined based on the closing market prices of the underlying securities at each year-end. The estimated fair value of our interest rate swap agreements was based on forward interest rates as of December 31, 2005.at each year-end and does not include accrued interest. The table below summarizes the estimated fair value, which is also the carrying value, of our financial instruments at December 31, 20052008 and 2004 2007 (in thousands)millions):
2005 | 2004 | ||||||
| Assets: | |||||||
| Foreign exchange forward contracts | $ | 4,823 | $ | - | |||
| Foreign exchange put options | 38,159 | 616 | |||||
| Equity forwards | 57,975 | 12,501 | |||||
| Equity collars | 15,332 | 21,796 | |||||
| Interest rate swap agreements | 9,604 | - | |||||
| Liabilities: | |||||||
| Foreign exchange forwards contracts | - | 39,105 | |||||
| Equity forwards | - | 12,961 | |||||
2008 | 2007 | |||||||
| Assets: | ||||||||
| Foreign exchange options | $ | 20 | $ | – | ||||
| Equity forwards | 40 | 24 | ||||||
| Interest rate swap agreements | 23 | 6 | ||||||
| Liabilities: | ||||||||
| Foreign exchange options | 31 | 14 | ||||||
| Foreign exchange forward contracts | – | 5 | ||||||
The financial instruments that we hold are entered into with a diversified selection of institutions with strong credit ratings, which minimizes the risk of loss due to nonpayment from the counterparty.institutions. Credit exposure is limited to the unrealized gains on our contracts. We have not experienced any material losses due to credit impairment of our financial instruments.
| Note 5. | FAIR VALUE MEASUREMENTS |
On January 1, 2008, we adopted FAS 157, which established a framework for measuring fair value under GAAP and clarified the definition of fair value within that framework. FAS 157 also established a fair value hierarchy that prioritizes the inputs used in valuation techniques into the following three levels:
Level 1—quoted prices in active markets for identical assets and liabilities
Level 2—observable inputs other than quoted prices in active markets for identical assets and liabilities
Level 3—unobservable inputs
A substantial majority of our financial instruments are Level 1 and Level 2 assets.
The following table sets forth the fair value of our financial assets and liabilities measured on a recurring basis, including those that are pledged as collateral or are restricted. Assets and liabilities are measured on a recurring basis if they are remeasured at least annually.
December 31, 2008 | December 31, 2007 | |||||||||||||||
| (In millions) | Assets | Liabilities | Assets | Liabilities | ||||||||||||
| Cash and cash equivalents | $ | 4,533 | $ | – | $ | 2,514 | $ | – | ||||||||
| Restricted cash | – | – | 788 | – | ||||||||||||
| Short-term investments | 1,665 | – | 1,461 | – | ||||||||||||
| Long-term marketable debt securities | 3,060 | – | 1,674 | – | ||||||||||||
| Total fixed income investment portfolio | 9,258 | – | 6,437 | – | ||||||||||||
| Long-term marketable equity securities | 287 | – | 416 | – | ||||||||||||
| Total derivative financial instruments | 83 | 31 | 30 | 19 | ||||||||||||
| Total | $ | 9,628 | $ | 31 | $ | 6,883 | $ | 19 | ||||||||
The following table sets forth the fair value of our financial assets and liabilities, allocated into Level 1, Level 2, and Level 3 that were measured on a recurring basis as of December 31, 2008 (in millions).
Level 1 | Level 2 | Level 3 | Total | |||||||||||||
| Assets | ||||||||||||||||
| Cash and cash equivalents | $ | 2,876 | $ | 1,657 | $ | – | $ | 4,533 | ||||||||
| Trading securities | 170 | 627 | – | 797 | ||||||||||||
| Securities available-for-sale | 515 | 3,268 | 145 | 3,928 | ||||||||||||
| Equity securities | 287 | – | – | 287 | ||||||||||||
| Derivative financial instruments | 40 | 43 | – | 83 | ||||||||||||
| Total | $ | 3,888 | $ | 5,595 | $ | 145 | $ | 9,628 | ||||||||
| Liabilities | ||||||||||||||||
Derivative financial instruments(1) | $ | – | $ | 31 | $ | – | $ | 31 | ||||||||
________________________
| (1) | Our Level 2 liabilities consisted of derivative financial instruments including currency forward contracts and currency option contracts. |
As of December 31, 2008, the fair value of our Level 1 assets was $3.9 billion, consisting primarily of cash, money market instruments, U.S. Treasury securities and marketable equity securities in biotechnology companies with which we have collaboration agreements. Included in this amount were gross unrecognized gains and losses of approximately $257 million and $1 million, respectively, primarily related to marketable equity securities.
As of December 31, 2008, the fair value of our Level 2 assets was $5.6 billion consisting primarily of corporate bonds, commercial paper, government and agency securities, municipal bonds and bonds denominated in foreign currencies but hedged to U.S. dollars. During 2008, we significantly reduced or eliminated our holdings in
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investments with a higher risk-profile such as commodities, non-investment grade debt, preferred and asset-backed securities. Asset-backed securities and preferred securities represented about 1% of the total value of Level 2 assets as of December 31, 2008. Included in our Level 2 assets were gross unrecognized losses of approximately $45 million primarily related to corporate bonds offset by approximately $45 million of gross unrecognized gains primarily related to government-backed securities. In addition, the fair value of our Level 2 assets included approximately $45 million in gross unrecognized gains related to foreign currency derivative contracts which are held to hedge forecasted foreign-currency-denominated royalty revenue and interest rate swaps used to hedge interest rate movements that impact the fair value of our Senior Notes. In 2008, the U.S. Treasury announced actions that significantly reduced the value of U.S. government agency preferred securities that we hold as investments. As a result, we recorded an impairment charge of $46 million during 2008.
As of December 31, 2008, our Level 3 assets consisted of student loan auction-rate securities and the preferred securities of an insolvent company. As of December 31, 2008, we held $145 million of investments, which were measured using unobservable (Level 3) inputs, representing about 2% of the total fair value investment portfolio. Student loan auction-rate securities of $145 million were valued based on broker-provided valuation models, which approximate fair value. In addition, our Level 3 assets included preferred securities in a financial institution that declared bankruptcy during 2008. We recorded an impairment charge of $21 million during 2008 to fully impair these preferred securities, because we do not expect to recover the value of these assets during the bankruptcy proceedings. We also transferred the preferred securities to Level 3 assets from Level 2 assets.
The following table sets forth a summary of the changes in the fair value of our Level 3 financial assets, which were measured at fair value on a recurring basis as December 31, 2008 (in millions).
December 31, 2008 | ||||||||||||
Structured Investment Vehicle Securities | Auction-Rate Securities | Preferred Securities | ||||||||||
| Beginning balance December 31, 2007 | $ | 7 | $ | – | $ | – | ||||||
| Transfer into Level 3 | – | 174 | 21 | |||||||||
| Impairment charges | – | – | (21 | ) | ||||||||
Unrealized losses(1) | (1 | ) | (26 | ) | – | |||||||
| Purchases, issuances, settlement | (6 | ) | (3 | ) | – | |||||||
| Ending balance | $ | – | $ | 145 | $ | – | ||||||
________________________
| (1) | The unrealized losses of $27 million in 2008 were included in OCI as of December 31, 2008. |
Note 6. | CONSOLIDATED FINANCIAL STATEMENT DETAIL |
Inventories
Inventories at December 31 are summarized below (in thousands)millions):
2005 | 2004 | ||||||
| Raw materials and supplies | $ | 78,618 | $ | 57,072 | |||
| Work in process | 438,270 | 436,329 | |||||
| Finished goods | 185,627 | 96,942 | |||||
| Total | $ | 702,515 | 590,343 | ||||
2008 | 2007 | |||||||
| Raw materials and supplies | $ | 122 | $ | 119 | ||||
| Work-in-process | 937 | 1,062 | ||||||
| Finished goods | 240 | 312 | ||||||
| Total | $ | 1,299 | $ | 1,493 | ||||
The carrying value of inventory which is neton our Consolidated Balance Sheets as of reserves of $8.3 million. The Lucentis inventory was included in work in process at December 31, 2005.2008 and 2007 included employee stock-based compensation costs of $61 million and $72 million, respectively. The carrying value of inventory on our Consolidated Balance Sheets as of December 31, 2008 also included retention plan costs of $27 million.
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Property, Plant and Equipment
Property, plant and equipment balances at December 31 are summarized below (in thousands)millions):
2005 | 2004 | ||||||
| At cost: | |||||||
| Land | $ | 376,316 | $ | 314,351 | |||
| Land improvements | 43,364 | 13,960 | |||||
| Buildings | 1,398,601 | 1,055,327 | |||||
| Equipment | 1,613,832 | 1,353,694 | |||||
| Leasehold improvements | 60,345 | 22,601 | |||||
| Construction-in-progress | 964,478 | 319,670 | |||||
| 4,456,936 | 3,079,603 | ||||||
| Less: accumulated depreciation and amortization | 1,107,584 | 988,199 | |||||
| Net property, plant and equipment | $ | 3,349,352 | $ | 2,091,404 | |||
2008 | 2007 | |||||||
| At cost: | ||||||||
| Land | $ | 418 | $ | 418 | ||||
| Land improvements | 50 | 48 | ||||||
| Buildings | 2,949 | 1,914 | ||||||
| Equipment | 2,803 | 2,318 | ||||||
| Leasehold improvements | 410 | 285 | ||||||
| Construction-in-progress | 834 | 1,675 | ||||||
| 7,464 | 6,658 | |||||||
| Less: accumulated depreciation and amortization | 2,060 | 1,672 | ||||||
| Net property, plant and equipment | $ | 5,404 | $ | 4,986 | ||||
Depreciation expense was $225.8$393 million in 2005, $171.22008, $334 million in 2004,2007, and $124.7$279 million in 2003.2006.
Other Accrued Liabilities
Other accrued liabilities at December 31 arewere as follows (in thousands)millions):
2005 | 2004 | ||||||
| Accrued compensation | $ | 253,292 | $ | 181,047 | |||
| Accrued royalties | 161,152 | 141,942 | |||||
Accrued clinical and other studies (including to related parties: 2005-$76,838; 2004-$59,067) | 221,423 | 154,492 | |||||
| Accrued marketing and promotion costs | 160,655 | 126,303 | |||||
| Taxes payable | 61,579 | 151,406 | |||||
Accrued collaborations (including to a related party: 2005-$42,242; 2004-$23,481) | 227,561 | 198,567 | |||||
Other (including to related parties: 2005-$12,694; 2004-$25,868) | 190,865 | 133,452 | |||||
| Total other accrued liabilities | $ | 1,276,527 | $ | 1,087,209 | |||
2008 | 2007 | |||||||
| Accrued compensation | $ | 634 | $ | 450 | ||||
| Accrued royalties | 283 | 270 | ||||||
Accrued clinical and other studies (including to related parties: 2008-$94; 2007-$106) | 303 | 357 | ||||||
| Accrued marketing and promotion costs | 175 | 181 | ||||||
| Taxes payable | 180 | 173 | ||||||
Accrued collaborations (including to a related party: 2008-$57; 2007-$50) | 313 | 267 | ||||||
Other (including to related parties: 2008-$29; 2007-$74) | 391 | 352 | ||||||
| Total other accrued liabilities | $ | 2,279 | $ | 2,050 | ||||
Interest and other income (expense), net at December 31 are as follows:Other Income, Net
2005 | 2004 | 2003 | ||||||||
(in millions) | ||||||||||
| Gains on sales of biotechnology equity securities and other | $ | 9.1 | $ | 11.9 | $ | 21.1 | ||||
| Write-downs of biotechnology debt, equity securities and other | (10.1 | ) | (12.4 | ) | (3.8 | ) | ||||
| Interest income | 141.9 | 90.5 | 78.4 | |||||||
| Total interest and other income (expense), net | $ | 140.9 | $ | 90.0 | $ | 95.7 | ||||
2008 | 2007 | 2006 | ||||||||||
| Gains on sales of biotechnology equity securities, net | $ | 109 | $ | 22 | $ | 93 | ||||||
| Write-downs of biotechnology debt and equity securities | (16 | ) | (20 | ) | (4 | ) | ||||||
| Interest income | ||||||||||||
| Investment income | 157 | 300 | 230 | |||||||||
| Impairment charges | (67 | ) | (30 | ) | – | |||||||
| Other miscellaneous income | 1 | 1 | 6 | |||||||||
| Total interest and other income, net | $ | 184 | $ | 273 | $ | 325 | ||||||
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Investment income and gains on sales of biotechnology equity securities, net were partially offset in 2008 by impairment charges of $67 million for preferred securities and in 2007 by a $30 million write-down of a fixed-income investment. Gains on sales of biotechnology equity securities included $30 million related to the sale of a biotechnology equity investment and $13 million in 2008 and $79 million in 2006 in gains that were recognized upon the acquisition of companies in which we owned equity securities.
Note 7. | OTHER INTANGIBLE ASSETS |
The components of our other intangible assets, including those arising from the Redemption and push-down accounting and our acquisition of Tanox at December 31, arewere as follows (in millions):
2005 | 2004 | ||||||||||||||||||
Gross Carrying Amount | Accumulated Amortization | Net Carrying Amount | Gross Carrying Amount | Accumulated Amortization | Net Carrying Amount | ||||||||||||||
| Developed product technology | $ | 1,194.1 | $ | 925.7 | $ | 268.4 | $ | 1,194.1 | $ | 847.7 | $ | 346.4 | |||||||
| Core technology | 443.5 | 372.1 | 71.4 | 443.5 | 351.0 | 92.5 | |||||||||||||
| Developed science technology | 467.5 | 467.5 | - | 467.5 | 452.9 | 14.6 | |||||||||||||
| Tradenames | 144.0 | 83.7 | 60.3 | 144.0 | 74.7 | 69.3 | |||||||||||||
| Patents | 166.9 | 64.6 | 102.3 | 138.0 | 53.2 | 84.8 | |||||||||||||
| Other intangible assets | 122.2 | 50.8 | 71.4 | 101.3 | 40.5 | 60.8 | |||||||||||||
| Total | $ | 2,538.2 | $ | 1,964.4 | $ | 573.8 | $ | 2,488.4 | $ | 1,820.0 | $ | 668.4 | |||||||
2008 | 2007 | ||||||||||||||||||||||||
Weighted Average Useful Life | Gross Carrying Amount | Accumulated Amortization | Net Carrying Amount | Gross Carrying Amount | Accumulated Amortization | Net Carrying Amount | |||||||||||||||||||
| Developed product technology | 12 years | $ | 1,974 | $ | 1,248 | $ | 726 | $ | 1,974 | $ | 1,106 | $ | 868 | ||||||||||||
| Core technology | 12 years | 478 | 437 | 41 | 478 | 414 | 64 | ||||||||||||||||||
| Trade names | 12 years | 144 | 105 | 39 | 144 | 98 | 46 | ||||||||||||||||||
| Patents and other intangible assets | 12 years | 370 | 168 | 202 | 331 | 141 | 190 | ||||||||||||||||||
| Total | $ | 2,966 | $ | 1,958 | $ | 1,008 | $ | 2,927 | $ | 1,759 | $ | 1,168 | |||||||||||||
Amortization expense of our other intangible assets iswas as follows (in millions):
2005 | 2004 | 2003 | ||||||||
| Acquisition-related intangible assets amortization | $ | 122.7 | $ | 145.5 | $ | 154.3 | ||||
| Patents amortization | 11.4 | 8.7 | 8.3 | |||||||
| Other intangible assets amortization | 10.3 | 27.8 | 8.1 | |||||||
| Total amortization expense | $ | 144.4 | $ | 182.0 | $ | 170.7 | ||||
2008 | 2007 | 2006 | ||||||||||
| Acquisition-related intangible assets amortization | $ | 172 | $ | 132 | $ | 105 | ||||||
| Patents and other intangible assets amortization | 27 | 26 | 23 | |||||||||
| Total amortization expense | $ | 199 | $ | 158 | $ | 128 | ||||||
The expected future annual amortization expense of our other intangible assets is as follows (in millions):
For the Year Ending December 31, | ||||
| 2006 | $ | 127.4 | ||
| 2007 | 126.1 | |||
| 2008 | 124.2 | |||
| 2009 | 75.2 | |||
| 2010 | 25.8 | |||
| Thereafter | 95.1 | |||
| Total expected future annual amortization | $ | 573.8 | ||
| For the Year Ending December 31, | ||||
| 2009 | $ | 152 | ||
| 2010 | 102 | |||
| 2011 | 101 | |||
| 2012 | 100 | |||
| 2013 | 98 | |||
| Thereafter | 455 | |||
| Total expected future annual amortization | $ | 1,008 | ||
Note 8. |
Commercial Paper Program
In October 2007, we issued $600 million in unsecured commercial paper notes payable for funding general corporate purposes. These notes are not redeemable prior to maturity or subject to voluntary prepayment, and are issued on a discount basis. We stopped issuing commercial paper in September 2008 in response to unfavorable changes in the credit markets, and our commercial paper obligations were fully paid by October 2008. In December 2008, we recommenced this funding program and issued $500 million of commercial paper in response to favorable changes in those markets. At December 31, 2008 and 2007, outstanding commercial paper notes carried an effective interest yield of 0.8% and 4.46%, respectively. Interest expense related to the commercial paper program was $13 million in 2008 and $5 million in 2007.
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Long-Term Debt
On July 18, 2005, we completed a private placement of the following debt instruments: $500.0$500 million principal amount of 4.40% Senior Notes due 2010, $1.0 billion principal amount of 4.75% Senior Notes due 2015 and $500.0$500 million principal amount of 5.25% Senior Notes due 2035 (collectively, the “Notes”)Notes). Interest on each series of the Notes is payable on January 15 and July 15 of each year, beginning on January 15, 2006. Net proceeds resulting from issuance of the Notes, after debt discount and issuance costs, were approximately $1.99 billion. The Notes contain certain restrictive covenants on incurring property liens and entering into sale and lease-back transactions, all of which we were in compliance with at December 31, 2005.2008. Interest expense related to the debt issuance, net of amounts capitalized of $1.7$39 million in 2008 and $41 million in 2007, was $41.3$54 million in 2008 and $60 million for 2005.2007. As of December 31, 2005,2008, the future minimum principal payments under the Notes are as follows (in millions):
| 2010 | $ | 500.0 | ||
| Thereafter | 1,500.0 | |||
| Total | $ | 2,000.0 |
| 2010 | $ | 500 | ||
| 2011 | – | |||
| Thereafter | 1,500 | |||
| Total | $ | 2,000 |
At December 31, 2005,2008 and 2007, the carrying value of the Notes was $2.0 billion, and the estimated fair value was $1.95 billion. At December 31, 2004, the carrying value, which approximates fair value, of the long-term debt related to the synthetic lease obligation on our Vacaville, California manufacturing facility, which we consolidated under the provisions of FIN 46R, was $412.3 million.$1.86 billion and $1.94 billion, respectively. The fair value of debt was estimated based on the then current rates offered to us for debt instruments with the same remaining maturities.
In July 2005, we entered into a series of interest rate swap agreements, related to debt maturing in 2010. See “Derivative Financial Instruments” in Note 4, “Investment Securities and Financial Instruments” for further discussion of the interest rate swaps.Long-term debt at December 31, 2008 and 2007 included $306 million and $399 million, respectively, in construction in progress financing obligations related to our agreements with HCP and Lonza. Long-term debt as of December 31, 2008, was reduced by a $200 million financing payment related to the construction of a manufacturing facility in Singapore. See Note 9, “Leases, Commitments, and Contingencies,” for further discussion of the Lonza agreements and HCP Master Lease Agreement.
Note 9. | LEASES, COMMITMENTS, AND CONTINGENCIES |
Leases
We lease various real properties under operating leases that generally require us to pay taxes, insurance, maintenance and minimum lease payments.
In December 2004, we entered into a Master Lease Agreement with Slough SSF, LLC, which was subsequently acquired by HCP, for the lease of property adjacent to our South San Francisco campus. The property will bewas developed into eight buildings and two parking structures. The lease of the property will take place in two phases pursuant to separate lease agreements for each building as contemplated by the Master Lease Agreement. Phase I building leases will begin throughout 2006 and Phase II building leases will begin in 2007 and continue through 2008. For accounting purposes, due to the nature of our involvement with the construction of the buildings subject to the Master Lease Agreement, we are considered to be the owner of the assets duringassets. Construction of these buildings was completed in 2008, and as of December 31, 2008, all of the construction period through the lease commencement date, even though the funds to construct the building shell and some infrastructure costs are paid by the lessor.buildings had been placed in service. As such, through the end of 2005,December 31, 2008, we havehad capitalized $93.6$298 million of construction costs, including capitalized interest, in property, plant and equipment, andequipment. In addition, we separately capitalized $311 million of leasehold improvements that we had installed at the property. We have also recognized a corresponding amount$274 million as a construction financing obligation, which is primarily included in “long-term“Long-term debt” in the accompanying consolidated balance sheets. We expect atConsolidated Balance Sheets. Concurrent with the time of completioncommencement of the project, if allrental period, during the buildings and infrastructure were completed bythird quarter of 2006, we began repayment of the lessor, our construction asset and related obligation will befinancing obligation. Included in excess of $365.0 million, excluding costs related to leasehold improvements. Our aggregatethese lease payments as contemplated by the Master Lease Agreement through 2020 will be approximately $543.7 million.is interest expense of $15 million in 2008 and $10 million in 2007.
Future minimum lease payments under all leases, exclusive of the residual value guarantees and executory costs at December 31, 2005,2008 are as follows (in millions). These minimum lease payments were computed based on interest rates current at that time, which are subject to fluctuations in certain market-based interest rates:time:
2006 | 2007 | 2008 | 2009 | 2010 | Thereafter | Total | ||||||||||||||||
| Operating leases | $ | 19.5 | $ | 20.3 | $ | 20.8 | $ | 20.0 | $ | 18.0 | $ | 82.0 | $ | 180.6 | ||||||||
| Slough leases | 8.8 | 18.9 | 31.1 | 35.4 | 36.6 | 412.9 | 543.7 | |||||||||||||||
| Total | $ | 28.3 | $ | 39.2 | $ | 51.9 | $ | 55.4 | $ | 54.6 | $ | 494.9 | $ | 724.3 | ||||||||
2009 | 2010 | 2011 | 2012 | 2013 | Thereafter | Total | ||||||||||||||||||||||
| Operating leases | $ | 27 | $ | 27 | $ | 25 | $ | 21 | $ | 21 | $ | 69 | $ | 190 | ||||||||||||||
| HCP leases | 36 | 37 | 39 | 40 | 41 | 298 | 491 | |||||||||||||||||||||
| Total | $ | 63 | $ | 64 | $ | 64 | $ | 61 | $ | 62 | $ | 367 | $ | 681 | ||||||||||||||
Rental expenses for our operating leases were $18.9$41 million in 2005, $12.32008, $37 million in 20042007, and $9.1$33 million in 2003.2006.
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Commitments
In December 2006, Lonza purchased all of the outstanding shares of Genentech España, our wholly-owned subsidiary, including the FDA-licensed Porriño facility, which is currently dedicated to the production of Avastin. We also entered into a supply agreement with Lonza for the manufacture of certain of our products at Lonza’s facility under construction in Singapore, which is currently expected to receive FDA licensure in 2010. We are committed to funding the pre-commissioning production qualification costs at that facility, and, upon FDA licensure, we are committed to purchasing 100 percent of products successfully manufactured at that facility for a period of three years after commissioning of the facility. The total estimated cost of these pre- and post-commissioning commitments is approximately $440 million, the majority of which will be paid in 2009 through 2012. We also received an exclusive option to purchase the Lonza Singapore facility during the period from 2007 up to one year after FDA licensure for a purchase price of $290 million. Regardless of whether the purchase option is exercised, we will be obligated to make a milestone payment of approximately $70 million if certain performance milestones are met in connection with the construction of the facility. As of December 31, 2008, we had not exercised our option to purchase.
In addition, we entered into a loan agreement with Lonza to advance up to $290 million to Lonza for the construction of the Singapore facility, subject to certain mutually acceptable conditions of securitization, and approximately $9 million for a related land lease option. In November 2008, the facility reached mechanical completion, and we advanced Lonza $200 million pursuant to the loan agreement. If we exercise our option to purchase the facility, any outstanding advances may be offset against the purchase price. If we do not exercise our purchase option, the advances will be offset against supply purchases.
In September 2004, we entered into a non-exclusive, long-term manufacturing agreement for the production of Herceptin bulk product with Wyeth Pharmaceuticals, a division of Wyeth (or “Wyeth”)(Wyeth). Under this agreement, Wyeth will manufacture Herceptin bulk drug substanceproduct for us for approximately $251 million through 2009 at their production facility in Andover, Massachusetts. We anticipate thatAs of December 31, 2008, our remaining purchase obligation to Wyeth will receivewas $84 million. In the third quarter of 2006, the FDA licensure and begin commercial productionapproved the manufacture of Herceptin bulk drug substance by the end of 2006.product at Wyeth’s facility.
Contingencies
We are a party to various legal proceedings, including patent infringement litigation andlitigations, licensing and contract disputes, and other matters.
On October 4, 2004, we received a subpoena from the United States (or “U.S.”)U.S. Department of Justice requesting documents related to the promotion of Rituxan, a prescription treatment now approved for the treatment of relapsed or refractory, low-grade or follicular, CD20 positive, B-cell non-Hodgkin’s lymphoma.five indications. We are cooperating with the associated investigation. Through counsel we are having discussions with government representatives about the status of their investigation which we haveand Genentech’s views on this matter, including potential resolution. Previously, the investigation had been advised is both civilcriminal and criminalcivil in nature. TheWe were informed in August 2008 by the criminal prosecutor who handled this matter that the government has informed us that it expectshad decided to call Genentech employeesdecline to appear before a grand juryprosecute the company criminally in connection with this investigation. The outcome of thiscivil matter cannot be determined at this time.
We and the City of Hope National Medical Center (or “COH”)COH are parties to a 1976 agreement relatingrelated to work conducted by two COH employees, Arthur Riggs and Keiichi Itakura, and patents that resulted from that work whichthat are referred to as the “Riggs/Itakura Patents.” Since that time,Subsequently, we have entered into license agreements with various companies to make,manufacture, use, and sell the products covered by the Riggs/Itakura Patents. On August 13, 1999, the COH filed a complaint against us in the Superior Court in Los Angeles County, California, alleging that we owe royalties to the COH in connection with these license agreements,
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as well as product license agreements that involve the grant of licenses under the Riggs/Itakura Patents. On June 10, 2002, a jury voted to award the COH approximately $300 million in compensatory damages. On June 24, 2002, a jury voted to award the COH an additional $200 million in punitive damages. Such amounts were accrued as an expense in the second quarter of 2002 and were included2002. Included within current liabilities in “Accrued litigation” in the accompanying consolidated balance sheets in “litigation-related and other long-term liabilities”Consolidated Balance Sheet at December 31, 2005 and December 31, 2004.2007 was $776 million, which represented our estimate of the costs for the resolution of the COH matter as of that reporting date. We filed a notice of appeal of the verdict and damages awards with the California Court of Appeal. On October 21, 2004,Appeal, and in subsequent proceedings the California Court of Appeal affirmed the verdict and damages awards in all respects. On November 22, 2004,Following the Californiadecision of the Court of Appeal, modified its opinion without changing the verdict and denied Genentech’s request for rehearing. On November 24, 2004, we filed a petition seeking review by the California Supreme Court. On February 2, 2005,Court which was granted, and on April 24, 2008 the California Supreme Court granted that petition. Theoverturned the award of $200 million in punitive damages to COH but upheld the award of $300 million in compensatory damages. We paid $476 million to COH in the second quarter of 2008, reflecting the amount of cash paid, if any, orcompensatory damages awarded plus interest thereon from the timing of such payment in connection with the COH matter will depend on the outcomedate of the California Supreme Court’s review of the matter; however, it may take longer than one year to further resolve the matter.original decision, June 10, 2002.
On April 11, 2003, MedImmune, Inc. (or “MedImmune”) filed a lawsuit against Genentech, COH, and Celltech R & D Ltd. in the U.S. District Court for the Central District of California (Los Angeles). The lawsuit relatesrelated to U.S. Patent No. 6,331,415 (or “the ‘415 patent” or “Cabilly patent”)(the Cabilly patent) that we co-own with COH and under which MedImmune and other companies have been licensed and are payinghave paid royalties to us.us under these licenses. The lawsuit includesincluded claims for violation of antitrust,anti-trust, patent, and unfair competition laws. MedImmune is seeking to havesought a ruling that the ‘415Cabilly patent declaredwas invalid and/or unenforceable, a determination that MedImmune doesdid not owe royalties under the ‘415Cabilly patent on sales of its Synagis®Synagis® antibody product, an injunction to prevent us from enforcing the ‘415Cabilly patent, an award of actual and exemplary damages, and other relief. On January 14, 2004 (amending a December 23, 2003 Order),June 11, 2008, we announced that we settled this litigation with MedImmune. Pursuant to the settlement agreement, the U.S. District Court granted summary judgment in our favor ondismissed all of MedImmune’s antitrust and unfair competition claims. MedImmune sought to amend its complaint to reallege certainthe claims for antitrust and unfair competition. On February 19, 2004, the Court denied this motion in its entirety and final judgment was entered in favor of Genentech and Celltech and against MedImmune on March 15, 2004 on all antitrust and unfair competition claims. MedImmune filed a notice of appeal of this judgment with the U.S. Court of Appeals for the Federal Circuit. Concurrently,us in the District Courtlawsuit. The litigation we filed a motion to dismiss all remaining claims in the case. On April 23, 2004, the District Court granted our motionhas been fully resolved and dismissed, all remaining claims. Final judgment was enteredand the settlement did not have a material effect on our operating results in our favor on May 3, 2004, thus concluding proceedings in the District Court. On October 18, 2005, the U.S. Court of Appeals for the Federal Circuit affirmed the judgment of the District Court in all respects. MedImmune filed a petition for a writ of certiorari with the United States Supreme Court on November 22, 2005 and we filed our response on December 27, 2005. No decision on the petition has been issued.2008.
On May 13, 2005, a request was filed by a third party for reexamination of the ‘415 or Cabilly patent. The request sought reexamination on the basis of non-statutory double patenting over U.S. Patent No. 4,816,567. On July 7, 2005, the U.S. Patent Office ordered reexamination of the ‘415Cabilly patent. On September 13, 2005, the Patent Office issuedmailed an initial “non-final”non-final Patent Office action rejecting theall 36 claims of the ‘415Cabilly patent. This action is a routine and expected next step in the reexamination procedure. We filed our response to the Patent Office action on November 25, 2005. TheOn December 23, 2005, a second request for reexamination of the Cabilly patent was filed by another third party, and on January 23, 2006, the Patent Office has not yet actedgranted that request. On June 6, 2006, the two reexaminations were merged into one proceeding. On August 16, 2006, the Patent Office mailed a non-final Patent Office action in the merged proceeding rejecting all the claims of the Cabilly patent based on this response.issues raised in the two reexamination requests. We filed our response to the Patent Office action on October 30, 2006. On February 16, 2007, the Patent Office mailed a final Patent Office action rejecting all the claims of the Cabilly patent. We responded to the final Patent Office action on May 21, 2007 and requested continued reexamination. On May 31, 2007, the Patent Office granted the request for continued reexamination, and in doing so withdrew the finality of the February 2007 Patent Office action and agreed to treat our May 21, 2007 filing as a response to a first Patent Office action. On February 25, 2008, the Patent Office mailed a final Patent Office action rejecting all the claims of the
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Cabilly patent. We filed our response to that final Patent Office action on June 6, 2008. On July 19, 2008, the Patent Office mailed an advisory action replying to our response and confirming the rejection of all claims of the Cabilly patent. We filed a notice of appeal challenging the rejection on August 22, 2008. Our opening appeal brief was filed on December 9, 2008. Subsequent to the filing of our appeal brief, the Patent Office continued the reexamination. The reexamination process is ongoing. The ‘415Cabilly patent, which expires in 2018, relates to methods that we and others use to make certain antibodies or antibody fragments, as well as cells and DNAdeoxyribonucleic acid (DNA) used in these methods. We have licensed the ‘415Cabilly patent to other companies and derive significant royalties from those licenses. The claims of the ‘415Cabilly patent remain valid and enforceable throughout the reexamination process.and appeals processes. The outcome of this matter cannot be determined at this time.
In 2006, we made development decisions involving our humanized anti-CD20 program, and our collaborator, Biogen Idec, disagreed with certain of our development decisions related to humanized anti-CD20 products. Under our 2003 collaboration agreement with Biogen Idec, we believe that we are permitted to proceed with further trials of certain humanized anti-CD20 antibodies, but Biogen Idec disagreed with our position. The disputed issues have been submitted to arbitration. Resolution of the arbitration could require that both parties agree to certain development decisions before moving forward with humanized anti-CD20 antibody clinical trials (and possibly clinical trials of other collaboration products, including Rituxan), in which case we may have to alter or cancel planned clinical trials in order to obtain Biogen Idec’s approval. Each party is also seeking monetary damages from the other. The arbitrators held hearings on this matter, and we expect a final decision from the arbitrators by no later than July 2009. The outcome of this matter cannot be determined at this time.
On December 23, 2005,June 28, 2003, Mr. Ubaldo Bao Martinez filed a second requestlawsuit against the Porriño Town Council and Genentech España S.L. in the Contentious Administrative Court Number One of Pontevedra, Spain. The lawsuit challenges the Town Council’s decision to grant licenses to Genentech España S.L. for reexaminationthe construction and operation of a warehouse and biopharmaceutical manufacturing facility in Porriño, Spain. On January 16, 2008, the Administrative Court ruled in favor of Mr. Bao on one of the ‘415 patent was filed by another third party.claims in the lawsuit and ordered the closing and demolition of the facility, subject to certain further legal proceedings. On January 23, 2006, the Patent office granted the reexamination request. The Patent Office has not yet acted on this request. Because the second request for reexaminationFebruary 12, 2008, we and the above-described reexamination proceedingTown Council filed appeals of the Administrative Court decision at the High Court in Galicia, Spain. In addition, through legal counsel in Spain we are ongoing,cooperating with Lonza to pursue additional licenses and permits for the finalfacility. We sold the assets of Genentech España S.L., including the Porriño facility, to Lonza in December 2006, and Lonza has operated the facility since that time. Under the terms of that sale, we retained control of the defense of this lawsuit and agreed to indemnify Lonza against certain contractually defined liabilities up to a specified limit, which is currently estimated to be approximately $100 million. The outcome of this matter and our indemnification obligation to Lonza, if any, cannot be determined at this time.
On May 30, 2008, Centocor, Inc. filed a patent lawsuit against Genentech and COH in the U.S. District Court for the Central District of California. The lawsuit relates to the Cabilly patent that we co-own with COH and under which Centocor and other companies have been licensed and have paid royalties to us under these licenses. The lawsuit seeks a declaratory judgment of patent invalidity and unenforceability with regard to the Cabilly patent and of patent non-infringement with regard to Centocor’s marketed product ReoPro® (Abciximab) and its unapproved product CNTO 1275 (Ustekinumab). Centocor originally sought to recover the royalties that it has paid to Genentech for ReoPro® and the monies it alleges that Celltech has paid to Genentech for Remicade® (infliximab), a product marketed by Centocor (a wholly-owned subsidiary of Johnson & Johnson) under an agreement between Centocor and Celltech, but Centocor withdrew those claims in connection with its first amended complaint filed on September 3, 2008. Genentech answered the complaint on September 19, 2008 and also filed counterclaims against Centocor alleging that four Centocor products infringe certain Genentech patents. Genentech filed an amendment to those counterclaims on October 10, 2008 and Centocor answered these counterclaims on November 26, 2008. The outcome of this matter cannot be determined at this time.
On May 8, June 11, August 8, and September 29 of 2008, Genentech was named as a defendant, along with InterMune, Inc. and its former chief executive officer, W. Scott Harkonen, in four originally separate class-action complaints filed in the U.S. District Court for the Northern District of California on behalf of plaintiffs who allegedly paid part or all of the purchase price for Actimmune® for the treatment of idiopathic pulmonary fibrosis. Actimmune® is an interferon-gamma product that was licensed by Genentech to Connectics Corporation and was subsequently assigned to InterMune. InterMune currently sells Actimmune® in the U.S. The complaints are related in part to royalties that we received in connection with the Actimmune® product. The May 8, June 11, and August 8
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complaints have been consolidated into a single amended complaint that claims and seeks damages for violations of federal racketeering laws, unfair competition laws, and consumer protection laws, and for unjust enrichment. The September 29 complaint includes six claims, but only names Genentech as a defendant in one claim for damages for unjust enrichment. Genentech’s motion to dismiss both complaints was heard on February 2, 2009. The outcome of these matters cannot be determined at this time.
Subsequent to the Roche Proposal, more than thirty shareholder lawsuits have been filed against Genentech and/or the members of its Board of Directors, and various Roche entities, including RHI, Roche Holding AG, and Roche Holding Ltd. The lawsuits are currently pending in various state courts, including the Delaware Court of Chancery and San Mateo County Superior Court, as well as in the United States District Court for the Northern District of California. The lawsuits generally assert class-action claims for breach of fiduciary duty and aiding and abetting breaches of fiduciary duty based in part on allegations that, in connection with Roche’s offer to purchase the remaining shares, some or all of the defendants failed to properly value Genentech, failed to solicit other potential acquirers, and are engaged in improper self-dealing. Several of the suits also seek the invalidation, in whole or in part, of the Affiliation Agreement, and an order deeming Articles 8 and 9 of the company’s Amended and Restated Certificate of Incorporation invalid or inapplicable to a potential transaction with Roche. The outcome of these matters cannot be determined at this time.
On October 27, 2008, Genentech and Biogen Idec Inc. filed a complaint against Sanofi-Aventis Deutschland GmbH (Sanofi), Sanofi-Aventis U.S. LLC, and Sanofi-Aventis U.S. Inc. in the Northern District of California, seeking a declaratory judgment that certain Genentech products, including Rituxan (which is co-marketed with Biogen Idec) do not infringe Sanofi’s U.S. Patents 5,849,522 (‘522 patent) and 6,218,140 (‘140 patent) and a declaratory judgment that the ‘522 and ‘140 patents are invalid. Also on October 27, 2008, Sanofi filed suit against Genentech and Biogen Idec in the Eastern District of Texas, Lufkin Division, claiming that Rituxan and at least eight other Genentech products infringe the ‘522 and ‘140 patents. Sanofi is seeking preliminary and permanent injunctions, compensatory and exemplary damages, and other relief. Genentech and Biogen Idec filed a motion to transfer this matter to the Northern District of California on January 22, 2009. In addition, on October 24, 2008, Hoechst GmbH filed with the ICC International Court of Arbitration (Paris) a request for arbitration with Genentech, relating to a terminated agreement between Hoechst’s predecessor and Genentech that pertained to the above-referenced patents and related patents outside the U.S. Hoechst is seeking payment of royalties on sales of Genentech products, damages for breach of contract, and other relief. Genentech intends to defend itself vigorously. The outcome of these matters cannot be determined at this time.
Note 10. | RELATIONSHIP WITH ROCHE HOLDINGS, INC. AND RELATED PARTY TRANSACTIONS |
Licensing Agreements Related to Genentech Products
We have a July 1999 amended and restated licensing and marketing agreement with F. Hoffmann-La Roche (or “Hoffman-La Roche”) and its affiliates granting them an option to license, use, and sell our products in non-U.S. markets. The major provisions of that agreement include the following:
| Ÿ | Roche may exercise its option to license our products upon the occurrence of any of the following: (1) the filing of the first IND for a product; (2) the date by which Genentech has clinical trial data and other information sufficient to enable the first Phase III trial in the U.S. (Phase II Completion) for a product; or (3) provided Roche has paid a fee of $10 million (Option Extension Fee) within a certain time following its decision not to exercise the option in (2) above, the date by which the first Phase III Trial for a product is completed and the results are known, available, analyzed and, in Genentech’s reasonable judgment, enable a U.S. BLA/NDA filing; |
| Ÿ | Roche’s options expire on October 25, 2015 except that Roche maintains: (1) a Phase II Completion option for those products for which Genentech has filed an IND prior to October 25, 2015, but which have not reached Phase II Completion; and (2) an option at Phase III completion for those products for which Roche had paid the Option Extension Fee at the Phase II Completion prior to October 25, 2015; |
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| Ÿ | If Roche exercises its option to license a product, it has agreed to reimburse Genentech for development costs as follows: (1) if exercise occurs upon the filing of an IND, Roche will pay 50% of development costs incurred prior to the filing and 50% of development costs subsequently incurred; (2) if exercise occurs at the completion of the first Phase II trial, Roche will pay 50% of development costs incurred through completion of the trial, 75% of development costs subsequently incurred for the initial indication, and 50% of subsequent development costs for new indications, formulations or dosing schedules; (3) if the exercise occurs at the completion of a Phase III trial, Roche will pay 50% of development costs incurred through completion of Phase II, 75% of development costs incurred through completion of Phase III, and 75% of development costs subsequently incurred; and half of the Option Extension Fee paid by Roche to preserve its right to exercise its option at the completion of a Phase III trial will be credited against the total development costs payable to Genentech upon the exercise of the option; and (4) each of Genentech and Roche have the right to “opt-out” of sharing development costs for an additional indication for a product for which Roche exercised its option, but could “opt-back-in” within 30 days of the other party’s decision to file for approval of the indication by paying twice what they would have owed for development of the indication if they had not opted out; |
| Ÿ | We agreed, in general, to manufacture for and supply to Roche its clinical requirements of our products at cost, and its commercial requirements at cost plus a margin of 20%; however, Roche will have the right to manufacture our products under certain circumstances; |
| Ÿ | Roche has agreed to pay, for each product for which Roche exercises its licensing option upon the filing of an IND or completion of the first Phase II trial, a royalty of 12.5% on the first $100 million on its aggregate sales of that product and thereafter a royalty of 15% on its aggregate sales of that product in excess of $100 million until the later in each country of the expiration of our last relevant patent or 25 years from the first commercial introduction of that product; |
| Ÿ | Roche will pay, for each product for which Roche exercises its licensing option after completion of a Phase III trial, a royalty of 15% on its sales of that product until the later in each country of the expiration of our last relevant patent or 25 years from the first commercial introduction of that product; however, the second half of the Option Extension Fee paid by Roche related to a product will be credited against royalties payable to us in the first calendar year of sales by Roche in which aggregate sales of that product exceed $100 million; and |
| Ÿ | For certain products for which Genentech is paying a royalty to Biogen Idec, including Rituxan, Roche shall pay Genentech a royalty of 20% on sales of such product in Roche’s licensed territory. Once Genentech is no longer obligated to pay a royalty to Biogen Idec on sales of such products in each country, Roche shall then pay Genentech a royalty on sales of 10% on the first $75 million on its aggregate sales of that product and thereafter a royalty of 8% on its aggregate sales of that product in excess of $75 million until the later in each country of the expiration of our last relevant patent or 25 years from the first commercial introduction of that product. During the fourth quarter of 2008, our obligation to pay a royalty to Biogen Idec on sales of Rituxan ended in certain countries. The shift from the 20% royalty on Rituxan to the lower 8% to 10% royalty rate will occur in certain countries during 2009 and beyond. |
We have further amended this licensing and marketing agreement with Roche to delete or add certain Genentech products under Roche’s commercialization and marketing rights for Canada.
We also have a July 1998 licensing and marketing agreement relatingrelated to anti-HER2 antibodies (Herceptin(including Herceptin and Omnitarg)pertuzumab) with Hoffmann-La Roche, providing them with exclusive marketing rights outside of the U.S. Under the agreement, Hoffmann-La Roche funds one-half of the global development costs incurred in connection with developing new indicationsanti-HER2 antibody products under the agreement. Either Genentech or Hoffmann-La Roche has the right to “opt-out” of developing an additional indication for a product and would not share the costs or benefits of the additional indication, but could “opt-back-in” beforewithin 30 days of the other party’s decision to file for approval of the indication by paying twice what would have been owed for development of the indication if no opt-out had occurred. Hoffmann-La Roche has also agreed to make royalty
payments of 20% on aggregate net sales of a product sales outside the U.S. up to $500.0$500 million in each calendar
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year and 22.5% on such sales in excess of $500.0$500 million in each calendar year. In December 2007, Roche opted-in to our trastuzumab drug conjugate products under terms similar to those of the existing anti-HER2 agreement (see also “Related Party Transactions” below).
Licensing Agreements Related to Roche Products
We have entered into certain licensing agreements with Roche and its affiliates that grant us licenses to develop and commercialize products discovered by Roche and its affiliates.
In April 2004,June 2008, we entered into a licensing agreement with Roche under which we obtained rights to a preclinical small-molecule drug development program. The future R&D costs incurred under the agreement and any profit and loss from global commercialization are to be shared equally with Roche.
In September 2008, we entered into a collaboration agreement with Roche and GlycArt for the joint development and commercialization of GA101, a humanized anti-CD20 monoclonal antibody for the potential treatment of hematological malignancies and other oncology-related B-cell disorders such as NHL. The future global R&D costs incurred under the agreement are to be shared equally with Roche. We received commercialization rights in the U.S. and have the right to manufacture our own commercial requirements for the U.S. In October 2008, Biogen Idec exercised the right under our collaboration agreement with them to opt in to this agreement.
Research Collaboration Agreement
We have an April 2004 research collaboration agreement with Hoffmann-La Roche that outlines the process by which Hoffmann-La Roche and Genentech may agree to conduct and share in the costs of joint research on certain molecules, other than with regard to anti-HER2 antibodies as described above.molecules. The agreement further outlines how development and commercialization efforts will be coordinated with respect to select molecules, including the financial provisions for a number of different development and commercialization scenarios undertaken by either or both parties.
Manufacturing Agreements
We signed two product supply agreements with Roche in July 2006, each of which was amended in November 2007. The Umbrella Manufacturing Supply Agreement (Umbrella Agreement) supersedes our existing product supply agreements with Roche. The Short-Term Supply Agreement (Short-Term Agreement) supplements the terms of the Umbrella Agreement. Under the Short-Term Agreement, Roche has agreed to purchase specified amounts of Herceptin, Avastin and Rituxan through 2008. Under the Umbrella Agreement, Roche has agreed to purchase specified amounts of Herceptin and Avastin through 2012 and, on a perpetual basis, either party may order other collaboration products from the other party, including Herceptin and Avastin after 2012, pursuant to certain forecast terms. The Umbrella Agreement also provides that either party may terminate its obligation to purchase and/or supply Avastin and/or Herceptin with six years notice on or after December 31, 2007. To date, we have not provided to or received from Roche such notice of termination.
In July 2008, we signed an agreement with Chugai Pharmaceutical Co., Ltd., a Japan-based entity and part of Roche, under which we agreed to manufacture Actemra, a product of Chugai, at our Vacaville, California facility. After an initial term of five years, the agreement may be terminated subject to certain terms and conditions under the contract.
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Tax Sharing Agreement
We have a tax sharing agreement with Roche that pertainsRHI. If we and RHI elect to thefile a combined state and local tax returnsreturn in whichcertain states where we are consolidated or combined with Roche. We calculatemay be eligible, our tax liability or refund with RocheRHI for these state and localsuch jurisdictions as if we werewill be calculated on a stand-alone entity.basis.
We issue additional shares of Common Stock in connection with our stock option and stock purchase plans, and we may issue additional shares for other purposes. Our affiliation agreementAffiliation Agreement with RocheRHI provides, among other things, that we establish a stock repurchase program designedwith respect to maintain Roche’s percentage ownership interest inany issuance of our Common Stock. The affiliation agreement provides thatStock in the future, we will repurchase a sufficient number of shares pursuant to this programso that immediately after such that, with respect to any issuance, of Common Stock by Genentech in the future, the percentage of Genentechour Common Stock owned by Roche immediately after such issuanceRHI will be no lower than Roche’s lowest percentage ownership of Genentech Common Stock at any time after the offering of Common Stock occurring in July 1999 and prior to the time of such issuance, except that Genentech may issue shares up to an amount that would cause Roche’s lowest percentage ownership to be no more than 2% below the “Minimum Percentage.”Percentage” (subject to certain conditions). The Minimum Percentage equals the lowest number of shares of Genentech Common Stock owned by RocheRHI since the July 1999 offering (to be adjusted in the future for dispositions of shares of Genentech Common Stock by RocheRHI as well as for stock splits or stock combinations) divided by 1,018,388,704 (to be adjusted in the future for stock splits or stock combinations), which is the number of shares of Genentech Common Stock outstanding at the time of the July 1999 offering, as adjusted for the two-for-one splits of Genentech Common Stock in November 1999, October 2000 and May 2004.stock splits. We have repurchased shares of our Common Stock insince 2001 through 2005 (see discussion above in Liquidity“Liquidity and Capital Resources). As long as Roche’s percentage ownership is greater than 50%, prior to issuing any shares, the affiliation agreement provides that we will repurchase a sufficient number of shares of our Common Stock such that, immediately after our issuance of shares, Roche’s percentage ownership will be greater than 50%Resources”). The affiliation agreementAffiliation Agreement also provides that, upon Roche’sRHI’s request, we will repurchase shares of our Common Stock to increase Roche’sRHI’s ownership to the Minimum Percentage. In addition, RocheRHI will have a continuing option to buy stock from us at prevailing market prices to maintain its percentage ownership interest. Roche publicly offered zero-coupon notes in January 2000 which were exchangeable for Genentech Common Stock held by Roche. Roche called these notes in March 2004. Through April 5, 2004, the expiration date for investors to tender these notes, a total of 25,999,324 shares were issued in exchange for the notes, thereby reducing Roche’s ownership of Genentech Common Stock to 587,189,380 shares. At December 31, 2005, Roche’s ownership percentage was 55.7%. The Minimum Percentage at December 31, 2005 was 57.7% and, underUnder the terms of the affiliation agreement, Roche’sAffiliation Agreement, RHI’s Minimum Percentage is 57.7% and RHI’s ownership percentage is to be no lower than 55.7%. At December 31, 2008, RHI’s ownership percentage was 55.8%.
The Roche Proposal and the Roche Tender Offer
We announced on July 21, 2008 that we received the Roche Proposal and on July 24, 2008 we announced that the Special Committee was formed to review and consider the terms and conditions of the Roche Proposal, any business combination with Roche or any offer by Roche to acquire our securities, negotiate as appropriate, and, in the Special Committee’s discretion, recommend or not recommend the acceptance of the Roche Proposal by the minority shareholders. On August 13, 2008, we announced that the Special Committee had unanimously concluded that the Roche Proposal substantially undervalues the company, but that the Special Committee would consider a proposal that recognizes the value of the company and reflects the significant benefits that would accrue to Roche as a result of full ownership. On January 30, 2009, Roche announced that it intended to commence a tender offer which would replace the Roche Proposal that was announced on July 21, 2008. On January 30, 2009, in response to the announcement by Roche, the Special Committee urged shareholders to take no action with respect to the announcement by Roche and that the Special Committee will announce a formal position within 10 business days following the commencement of such a tender offer by Roche. On February 9, 2009, Roche commenced the Roche Tender Offer. The Roche Tender Offer is conditional upon, among other things, (i) a non-waivable condition that holders of at least a majority of the outstanding publicly-held Genentech shares tender their shares in the Roche Tender Offer and (ii) a condition, which may be waived by Roche in its sole discretion, that Roche has obtained sufficient financing to purchase all outstanding publicly-held Genentech shares and all Genentech shares issuable upon exercise of outstanding options and to pay related fees and expenses. Also on February 9, 2009, the Special Committee urged shareholders to take no action with respect to the Roche Tender Offer. The Special Committee also announced that it intended to take a formal position within 10 business days of the commencement of the Roche Tender Offer, and will explain in detail its reasons for that position by filing a Statement on Schedule 14D-9 with the SEC.
On August 18, 2008, we also announced that the Special Committee adopted two retention plans that were implemented in lieu of our 2008 annual stock option grant and two severance plans that were adopted in addition to our existing severance plans. See Note 3, “Retention Plans and Employee Stock-Based Compensation,” for more information on the retention plans. In addition, the Special Committee and the company have incurred and will continue to incur third-party legal and advisory costs in connection with the Roche Proposal and the Roche Tender Offer that are included in the “Marketing, general and administrative” expenses line of our Consolidated Statements of Income.
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The retention plan and third-party legal and advisory costs were as follows (in millions):
2008 | ||||
Retention plan costs(1) | ||||
| Research and development | $ | 66 | ||
| Marketing, general and administrative | 69 | |||
| Total retention plan costs | 135 | |||
| Third-party legal and advisory costs incurred by us on behalf of the Special Committee | 14 | |||
| Other third-party legal and advisory costs | 4 | |||
| Total retention plan costs and legal and advisory costs | $ | 153 | ||
_______________________
| (1) | In 2008, an additional $27 million of retention plan costs were capitalized into inventory, which will be recognized as COS as products that were manufactured after the initiation of the retention plans are estimated to be sold. |
Related Party Transactions
We enter into transactions with our related parties, Roche and other Roche affiliates (including Hoffmann-La Roche) and Novartis, under existing agreements in the ordinary course of business.Novartis. The accounting policies that we apply to our transactions with our related parties are consistent with those applied in transactions with independent third-parties.third parties.
In our royalty and supply arrangements with related parties, we are the principal, as defined under EITF 99-19, because we bear the manufacturing risk, general inventory risk, and the risk to defend our intellectual property. For circumstances in which we are the principal in the transaction, we record the transaction on a gross basis in accordance with EITF 99-19. Otherwise our transactions are recorded on a net basis.
Roche
Under the July 1999 amended and restated licensing and commercialization agreement, Roche has the right to opt in to development programs that we undertake on our products at certain pre-defined stages of development. Previously, Roche also had the right to develop certain products under the July 1998 licensing and commercialization agreement related to anti-HER2 antibodies (including Herceptin, pertuzumab, and trastuzumab-DM1). When Roche opts in to a program, we generally record the opt-in payments that we receive as deferred revenue, which we recognize over the expected development periods or product life, as appropriate. During 2008, we received approximately $110 million from Roche related to opt-ins to various programs, most of which was recorded as deferred revenue. As of December 31, 2008, the amounts in short-term and long-term deferred revenue related to opt-in payments received from Roche were $57 million and $214 million, respectively. In 2008, 2007, and 2006, we recognized $76 million, $40 million, and $27 million, respectively, as contract revenue related to opt-in payments previously received from Roche.
In February 2008, Roche acquired Ventana, and as a result of the acquisition, Ventana is considered a related party. We have engaged in transactions with Ventana prior to and since the acquisition.
In May 2008, Roche acquired Piramed. Prior to the Roche acquisition of Piramed, we had entered into a licensing agreement with Piramed related to molecules targeting the PI3 kinase pathway.
In June 2008, we entered into a licensing agreement with Roche under which we obtained rights to a preclinical small-molecule drug development program. We recorded $35 million in R&D expense in the second quarter of 2008 related to this agreement. The future R&D costs incurred under the agreement and any profit and loss from global commercialization will be shared equally with Roche.
In July 2008, we signed an agreement with Chugai Pharmaceutical Co., Ltd., a Japan-based entity and part of Roche, under which we agreed to manufacture Actemra, a product of Chugai, at our Vacaville, California facility. After an initial term of five years, the agreement may be terminated subject to certain terms and conditions under the contract.
In June 2003, Hoffmann-La Roche exercised its optionAugust 2008, we entered into a Companion Diagnostics Master Agreement with RMS under which we have the ability to license from us the rightswork with RMS to market Avastin for all countries outside of the U.S. under its existing licensing agreement with us. As part of its opt-in, Hoffmann-La Roche paid us approximately $188.0 million and will pay 75% of subsequent Avastin global development costs unless Hoffmann-La Roche specifically opts out of the development of certain other indications.We will receive royaltiesdevelop companion diagnostics based on net sales of Avastin in countries outside of the U.S. Hoffmann-La Roche received approval for Avastin in Israel in September 2004, in Switzerland in December 2004 and from the European Union in January 2005 for the treatment of patients with previously untreated metastatic cancer of the colon or rectum.RMS’ polymerase chain reaction platform technology.
In September 2003, Hoffmann-La2008, we entered into a collaboration agreement with Roche exercised its option to license from usand GlycArt for the rights to marketjoint development and commercialization of GA101, a humanized anti-CD20 monoclonal antibody that bindsfor the potential treatment of hematological malignancies and other oncology-related B-cell disorders such as NHL. We recorded $105 million in R&D expense in 2008 related to CD20,this collaboration. The future global R&D costs incurred under the agreement will be shared equally with Roche. We received commercialization rights in the U.S. and have the right to manufacture our own commercial requirements for all countries outsidethe U.S. In October 2008, Biogen Idec exercised the right under our collaboration agreement with them to opt in to this agreement and paid us an up-front fee of $32 million as part of the U.S. (other than territory previously committedopt-in, which we will recognize ratably as contract revenue over the future development period.
We currently have no commercialized products subject to others) under the existing licensing agreement. As part of its opt-in, Hoffmann-La Roche paid us $8.4 million and agreed to pay 50% of subsequent global development costs related to the humanized anti-CD20 antibody unless Roche opts out of the development of certain indications. We will receive royalties on the humanized anti-CD20 antibody in countries outside of the U.S.profit sharing arrangements with Roche.
2008 | 2007 | 2006 | ||||||||||
| Product sales to Roche | $ | 868 | $ | 768 | $ | 359 | ||||||
| Royalties earned from Roche | $ | 1,544 | $ | 1,206 | $ | 846 | ||||||
| Contract revenue from Roche | $ | 138 | $ | 95 | $ | 125 | ||||||
| Cost of sales on product sales to Roche | $ | 472 | $ | 422 | $ | 268 | ||||||
| R&D expenses incurred on joint development projects with Roche | $ | 336 | $ | 259 | $ | 213 | ||||||
| In-licensing expenses to Roche | $ | 145 | – | – | ||||||||
Based on information available to us at the time of filing this Form 10-K, we believe that the Novartis Group holds approximately 33.3% of the outstanding voting shares of Roche Holding Ltd.Roche. As a result of this ownership, the Novartis Group is deemed to have an indirect beneficial ownership interest under FAS 57, “Related Party Disclosures” of more than 10% of Genentech’sour voting stock.
We have an agreement with Novartis Ophthalmics (now merged intoPharma AG (a wholly-owned subsidiary of Novartis AG) under which Novartis OphthalmicsPharma AG has the exclusive right to develop and market Lucentis outside of the U.S. and Canada for indications related to diseases or disorders of the eye. As part of this agreement, in 2003, Novartis Ophthalmics paid an upfront milestone and R&D reimbursement fee of $46.6 million and the parties will share the cost of certain of Genentech’sour ongoing Phase III and related development expenses. Genentech is not responsibleexpenses for any portion of the development and commercialization costs incurred by Novartis for the trials for which it is solely responsible outside of the U.S. and Canada, but we may receive additional payments for Novartis’ achievement of certain clinical development and product approval milestones outside of that region. In addition, we will receive royalties on net sales of Lucentis products, which we will manufacture and supply to Novartis, outside of the U.S. and Canada.Lucentis.
Under our existing arrangements with Novartis, we recognized the following amounts (in millions):
2008 | 2007 | 2006 | ||||||||||
| Product sales to Novartis | $ | 12 | $ | 10 | $ | 5 | ||||||
| Royalties earned from Novartis | $ | 241 | $ | 95 | $ | 3 | ||||||
| Contract revenue from Novartis | $ | 60 | $ | 70 | $ | 40 | ||||||
| Cost of sales on product sales to Novartis | $ | 9 | $ | 10 | $ | 4 | ||||||
| R&D expenses incurred on joint development projects with Novartis | $ | 43 | $ | 43 | $ | 38 | ||||||
| Collaboration profit sharing expense to Novartis | $ | 189 | $ | 185 | $ | 187 | ||||||
Contract revenue in 2007 included a $30 million milestone payment from Novartis relatedfor European Union approval of Lucentis for the treatment of neovascular (wet) AMD.
Certain R&D expenses are partially reimbursable to manufacturing, commercial and ongoing development activities, was $49.9 million in 2005, $48.6 million in 2004, and $24.2 million in 2003. Revenue fromus by Novartis. The amounts that Novartis relatedowes us, net of amounts reimbursable to product sales was not material in 2005 or in prior years. COS was $16.9 million in 2005, which included a one-time payment in the second quarter of 2005 related to our release from future manufacturing obligations. COS was not material in 2004 and 2003.Novartis by us on those projects, are recorded as contract revenue. Conversely, R&D expenses may include the net settlement of amounts relatedwe owe Novartis for R&D expenses that Novartis incurred on joint development projects, less amounts reimbursable to us by Novartis of $44.8 million in 2005, $44.3 million in 2004, and $22.7 million in 2003. Collaboration profit sharing expenses were $136.4million in 2005, $75.1 million in 2004, and $9.9 million in 2003.on these projects.
See Note 11, “Acquisition of Tanox, Inc.,” for information on Novartis’ share of the proceeds resulting from our acquisition of Tanox.
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Note 11. |
On August 2, 2007, we completed our acquisition of 100% of the outstanding shares of Tanox, a biotechnology company specializing in the discovery and development of biotherapeutics based on monoclonal antibody technology, for $925 million in cash, plus $8 million in transaction costs. The purchase price allocation is as follows:
| (In millions) | ||||
| Assets | ||||
| Cash | $ | 100 | ||
| Investments | 102 | |||
| Working capital and other, net | 54 | |||
| In-process research and development | 77 | |||
| Developed product technology | 780 | |||
| Core technology | 34 | |||
| Goodwill | 261 | |||
| Deferred revenue | (185 | ) | ||
| Deferred tax liability, net | (217 | ) | ||
| Total acquisition consideration and gain | $ | 1,006 | ||
| Consideration and gain | ||||
| Consideration | $ | 925 | ||
| Transaction costs | 8 | |||
| Gain on settlement of preexisting relationship, net of tax | 73 | |||
| $ | 1,006 | |||
In the third quarter of 2008, we adjusted the purchase price allocation by recording a net increase to goodwill of $13 million, due to revised estimates of certain restructuring liabilities and related deferred tax assets.
In accordance with FAS No. 141, “Business Combinations” (FAS 141), assets and liabilities acquired were valued at their fair values at the date of acquisition. We recorded deferred revenue associated with Tanox’s intellectual property license with Novartis related to Xolair of $185 million, which will be recognized as additional royalty revenue over the duration of the estimated remaining patent lives of approximately 12 years.
In connection with our acquisition of Tanox, we terminated certain officers and employees of Tanox. The total amount of the severance packages offered to these officers and employees was approximately $4 million.
We recorded a $77 million charge for in-process research and development. This charge primarily represents acquired R&D for label extensions for Xolair that have not yet been approved by the FDA and require significant further development.
Under FAS 141, acquired identifiable intangible assets are measured and recognized apart from goodwill, even if it would not be practical to sell or exchange the acquired intangible assets and any related license agreements apart from one another. In our accounting for our acquisition of Tanox’s developed product technology and core technology in accordance with FAS 142, the fair value assigned to those intangible assets was based on valuations using a present value technique referred to as the income approach, with estimates and assumptions determined by management, including valuing Tanox’s intellectual property and rights thereon at assumed current fair values, which, for developed product technology, were in excess of existing contractual rates. The developed product technology that we valued is related to intellectual property and rights thereon primarily related to the Xolair molecule. The core technology asset that we valued represents the value of Tanox’s intellectual property and rights thereon expected to be leveraged in the design and development of future products and indications. The developed product technology and core technology, which totaled $814 million, are being amortized over 12 years. The excess of purchase price over tangible assets, identifiable intangible assets, and assumed liabilities represents goodwill.
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The intangible assets and goodwill acquired are not deductible for income tax purposes. As a result, we recorded a net deferred tax liability of $262 million, based on the tax effect of the amount of the acquired intangible assets other than goodwill with no tax basis. We also recorded a net deferred tax asset of $45 million, primarily related to net operating loss carryforwards acquired in the transaction.
Under EITF 04-1, a business combination between parties with a preexisting relationship should be evaluated to determine if a settlement of a preexisting relationship exists. The acquisition of Tanox is considered to include the settlement of our 1996 license of certain intellectual property and rights thereon from Tanox. We measured the amount that the preexisting license arrangement is favorable, from our perspective, by comparing it to estimated pricing for current market transactions for intellectual property rights similar to Tanox’s intellectual property rights related to Xolair. In connection with the settlement of this license arrangement, we recorded a gain of $121 million, or $73 million net of tax, in accordance with EITF 04-1.
We understand that on August 2, 2007, Novartis owned approximately 14% of the outstanding shares of Tanox, representing approximately $127 million of the total cash paid to acquire the outstanding shares of Tanox.
Assuming that the Tanox acquisition was consummated as of January 1, 2006, pro forma consolidated financial results of the company for the year ended December 31, 2007 and 2006 would not have been materially different from the amounts reported.
| Note 12. | CAPITAL STOCK |
Common Stock and Special Common Stock
On June 30, 1999, we redeemed all of our outstanding Special Common Stock held by stockholders other than Roche.RHI. Subsequently, in July and October 1999, and March 2000, RocheRHI consummated public offerings of our Common Stock. On January 19, 2000, RocheRHI completed an offering of zero-coupon notes that were exchanged prior to the April 5, 2004 expiration for an aggregate of approximately 26.026 million shares of our Common Stock held by Roche.RHI. See “RedemptionNote 1, “Description of Business—Redemption of Our Special Common Stock” and Note 10, “Relationship with Roche” notesRoche Holdings, Inc. and Related Party Transactions,” above for a discussion of ourthe Redemption and the related transactions.
Stock Repurchase Program
Under a stock repurchase program approved by our Board of Directors in December 5, 2003 and most recently extended in September 2004 and June 2005, Genentech isApril 2008, we are authorized to repurchase up to 80,000,000150 million shares of our Common Stock for an aggregate price of up to $4.0$10.0 billion through June 30, 2006.2009. In this program, as in previous stock repurchase programs, purchases may be made in the open market or in privately negotiated transactions from time to time at management’s discretion. GenentechWe also may engage in transactions in other Genentech securities in conjunction with the repurchase program, including certain derivative securities. Genentech intendssecurities, although as of December 31, 2008, we had not engaged in any such transactions. We intend to use the repurchased stock to offset dilution caused by the issuance of shares in connection with Genentech’sour employee stock plans. However, significant option exercises and stock purchases by employees could result in further dilution, and limitations in our ability to enter into new share repurchase arrangements could negatively affect our ability to offset dilution. Although there are currently no specific plans for the shares that may be purchased under the program, our goals for the program are (i) to address provisions of our Affiliation Agreement with RHI related to maintaining RHI’s minimum ownership percentage (see Note 10, “Relationship with Roche Holdings, Inc. and Related Party Transactions” above), (ii) to make prudent investments of our cash resources; (ii)resources, and (iii) to allow for an effective mechanism to provide stock for our employee stock plans; and (iii) to address provisions of our affiliation agreement with Roche relating to maintaining Roche’s minimum ownership percentage (see above in Note 8, “Relationship with Roche and Related Party Transactions”). Under a previous stock repurchase program approved by our Board of Directors, we were authorized to repurchase up to $1.0 billion of our Common Stock through the period ended June 30, 2003.plans.
We have enteredenter into Rule 10b5-1 trading plans to repurchase shares in the open market during those periods each quarter when trading in our stock is restricted under our insider trading policy. The trading plans cover approximately 2.3 million shares and the current plan is effective through June 30, 2006.
In November 2007, we entered into a prepaid share repurchase arrangement with an investment bank pursuant to which we delivered $300 million to the investment bank. The prepaid amount has been reflected as a reduction of Genentech are eligible to participate in the 1991 Plan. Of the 46.4 million shares of Common Stock reserved for issuance under the 1991 Plan, 45.1 million shares have been issuedour stockholders’ equity as of December 31, 2005. During 2005,2007. Under this arrangement, the investment bank delivered approximately 7,800 eligible employees participated in the 1991 Plan.four million shares to us on March 31, 2008.
Shares (in thousands) | Weighted-Average Exercise Price | ||||||
| Options outstanding at December 31, 2002 | 110,838 | $ | 19.19 | ||||
| Grants | 21,780 | 40.55 | |||||
| Exercises | (32,078 | ) | 34.14 | ||||
| Cancellations | (4,414 | ) | 23.80 | ||||
| Options outstanding at December 31, 2003 | 96,126 | 25.18 | |||||
| Grants | 20,967 | 53.04 | |||||
| Exercises | (21,484 | ) | 20.81 | ||||
| Cancellations | (1,843 | ) | 29.92 | ||||
| Options outstanding at December 31, 2004 | 93,766 | 32.32 | |||||
| Grants | 19,675 | 84.01 | |||||
| Exercises | (28,823 | ) | 25.88 | ||||
| Cancellations | (1,814 | ) | 42.16 | ||||
| Options outstanding at December 31, 2005 | 82,804 | $ | 46.64 | ||||
As of December 31, 2005 | ||||||||||||||||
Options Outstanding | Options Exercisable | |||||||||||||||
Range of Exercise Prices | Number Outstanding (in thousands) | Weighted-Average Years Remaining Contractual Life | Weighted-Average Exercise Price | Number Exercisable (in thousands) | Weighted-Average Exercise Price | |||||||||||
| $6.27 - $8.89 | 567 | 5.29 | $ | 7.64 | 567 | $ | 7.64 | |||||||||
| $10.00 - $14.35 | 14,358 | 5.96 | $ | 13.75 | 10,581 | $ | 13.56 | |||||||||
| $15.04 - $22.39 | 9,444 | 5.35 | $ | 20.82 | 9,067 | $ | 20.94 | |||||||||
| $22.88 - $33.00 | 343 | 5.34 | $ | 27.51 | 336 | $ | 27.56 | |||||||||
| $35.63 - $53.23 | 38,266 | 7.79 | $ | 46.78 | 16,561 | $ | 44.36 | |||||||||
| $53.95 - $75.90 | 1,575 | 8.78 | $ | 59.39 | 336 | $ | 56.13 | |||||||||
| $81.15 - $98.80 | 18,251 | 9.73 | $ | 86.03 | 3 | $ | 85.83 | |||||||||
| 82,804 | 37,451 | |||||||||||||||
Note 13. | INCOME TAXES |
The income tax provision consistsconsisted of the following amounts (in thousands)millions):
2005 | 2004 | 2003 | ||||||||
| Current: | ||||||||||
| Federal | $ | 723,191 | $ | 444,317 | $ | 389,354 | ||||
| State | 120,362 | 63,868 | 46,971 | |||||||
| Total current | 843,553 | 508,185 | 436,325 | |||||||
| Deferred: | ||||||||||
| Federal | (84,672 | ) | (50,179 | ) | (133,085 | ) | ||||
| State | (25,023 | ) | (23,406 | ) | (15,916 | ) | ||||
| Total deferred | (109,695 | ) | (73,585 | ) | (149,001 | ) | ||||
| Total income tax provision | $ | 733,858 | 434,600 | 287,324 | ||||||
2008 | 2007 | 2006 | ||||||||||
| Current: | ||||||||||||
| Federal | $ | 1,744 | $ | 1,729 | $ | 1,306 | ||||||
| State | 170 | 162 | 96 | |||||||||
| Total current | 1,914 | 1,891 | 1,402 | |||||||||
| Deferred: | ||||||||||||
| Federal | 84 | (251 | ) | (155 | ) | |||||||
| State | 6 | 17 | 43 | |||||||||
| Total deferred | 90 | (234 | ) | (112 | ) | |||||||
| Total income tax provision | $ | 2,004 | $ | 1,657 | $ | 1,290 | ||||||
Tax benefits of $641.3$140 million in 2005, $329.52008, $177 million in 2004,2007, and $265.0$179 million in 20032006 are related to employee stock options and stock purchase plans. These amounts reduced current income taxes payable and deferred income taxes and were credited to stockholders’ equity.
A reconciliation between our incomeeffective tax provisionrate and the amount computed by multiplying income before taxes by the U.S. statutory tax rate follows (in thousands):follows:
2005 | 2004 | 2003 | ||||||||
| Tax at U.S. statutory rate of 35% | $ | 704,497 | $ | 426,795 | $ | 314,127 | ||||
| Research and other credits | (29,885 | ) | (43,736 | ) | (23,531 | ) | ||||
| Prior years’ items | (14,364 | ) | - | (34,819 | ) | |||||
| Export sales benefit | (7,875 | ) | (6,181 | ) | (10,325 | ) | ||||
| State taxes | 100,000 | 60,484 | 44,842 | |||||||
| Deduction for qualified production activities | (15,610 | ) | - | - | ||||||
| Tax-exempt investment income | (5,618 | ) | (3,718 | ) | (3,680 | ) | ||||
| Other | 2,713 | 956 | 710 | |||||||
| Income tax provision | $ | 733,858 | $ | 434,600 | $ | 287,324 | ||||
2008 | 2007 | 2006 | ||||||||||
| Tax at U.S. statutory rate | 35.0 | % | 35.0 | % | 35.0 | % | ||||||
| Research and other credits | (1.7 | ) | (2.1 | ) | (2.3 | ) | ||||||
| In-process research and development | – | 0.6 | – | |||||||||
| Prior years’ items | 0.3 | – | 0.9 | |||||||||
| Export sales benefit | – | – | (0.3 | ) | ||||||||
| State taxes | 3.9 | 4.8 | 5.0 | |||||||||
| Deduction for qualified production activities | (1.2 | ) | (1.2 | ) | (0.7 | ) | ||||||
| Tax-exempt investment income | (0.1 | ) | (0.2 | ) | (0.2 | ) | ||||||
| Other | 0.7 | 0.5 | 0.5 | |||||||||
| Effective tax rate | 36.9 | % | 37.4 | % | 37.9 | % | ||||||
Prior years’ items in 20052008 include $39.0 millionIRS audit adjustments related to research credits and foreign royalty income. Prior years’ items in additional2006 related to a decrease in research credits resulting from new income tax regulations issued by the U.S. Department of Treasury during 2005, partially offset by other changes in estimates of prior years’ research credits. Prior years’ items in 2003 include additional research credits resulting from the settlement of IRS examinations in 2003. Other prior years’ items relate principally to changes in estimates resulting from events in 2003 that provided greater certainty as to the expected outcome of prior years’ matters.2006.
The components of deferred taxes consistconsisted of the following at December 31 (in thousands)millions):
2005 | 2004 | ||||||
| Deferred tax liabilities: | |||||||
| Depreciation | $ | (188,713 | ) | $ | (223,034 | ) | |
| Unrealized gain on securities available-for-sale | (172,212 | ) | (197,229 | ) | |||
| Intangibles - Roche transaction | (160,068 | ) | (209,167 | ) | |||
| Other intangible assets | (40,948 | ) | (33,923 | ) | |||
| Other | (10,876 | ) | (14,621 | ) | |||
| Total deferred tax liabilities | (572,817 | ) | (677,974 | ) | |||
| Deferred tax assets: | |||||||
| Capitalized R&D costs | 18,682 | 24,447 | |||||
| Federal credit carryforwards | - | 22,953 | |||||
| Expenses not currently deductible | 430,977 | 370,704 | |||||
| Deferred revenue | 105,768 | 125,506 | |||||
| Investment basis difference | 208,810 | 205,636 | |||||
| State credit carryforwards | 114,279 | 93,710 | |||||
| Other | 6,772 | 3,729 | |||||
| Total deferred tax assets | 885,288 | 846,685 | |||||
| Total net deferred tax assets | $ | 312,471 | $ | 168,711 | |||
2008 | 2007 | |||||||
| Deferred tax liabilities: | ||||||||
| Depreciation | $ | (241 | ) | $ | (147 | ) | ||
| Unrealized gain on securities available-for-sale | (84 | ) | (136 | ) | ||||
| Intangibles—Roche transaction | (34 | ) | (75 | ) | ||||
| Other intangible assets | (325 | ) | (361 | ) | ||||
| Other | (33 | ) | (14 | ) | ||||
| Total deferred tax liabilities | (717 | ) | (733 | ) | ||||
| Deferred tax assets: | ||||||||
| Capitalized R&D costs | 8 | 11 | ||||||
| State income taxes | 51 | – | ||||||
| Employee stock-based compensation costs | 291 | 217 | ||||||
| Expenses not currently deductible | 419 | 598 | ||||||
| Deferred revenue | 208 | 195 | ||||||
| Investment basis difference | 217 | 204 | ||||||
| Net operating loss carryforwards | 13 | 33 | ||||||
| Other | – | 5 | ||||||
| Total deferred tax assets | 1,207 | 1,263 | ||||||
| Total net deferred tax assets | $ | 490 | $ | 530 | ||||
We file income tax credit carryforwardsreturns in the U.S. federal jurisdiction and various state and local and foreign jurisdictions. With few exceptions, we are no longer subject to U.S. federal, state and local, or foreign income tax examinations by tax authorities for the years before 2002. The IRS has concluded the examination of $114.0our U.S. income tax returns for 2002 through 2004. We have agreed to certain adjustments related to R&D credits and foreign licensing income for which all related tax and interest was paid to the IRS in the fourth quarter of 2008. We will appeal one proposed adjustment related to R&D credits in the first quarter of 2009. The IRS may also adjust R&D credits for 2002 through 2004 for the flow-through effects of the IRS’ separate examinations of Roche’s R&D credits. The IRS is scheduled to begin the examination of our U.S. income tax returns for 2005 through 2007 in the first quarter of 2009. Our income tax filings are also currently under examination by several state jurisdictions and one foreign jurisdiction. As of December 31, 2008, no material adjustments had been proposed. We believe that we have adequately provided for reasonably foreseeable outcomes related to tax audits, appeals, and flow-through effects of changes in Roche’s R&D credits and that any settlements will not have material adverse effects on our consolidated financial position or results of operations. However, there can be no assurances as to possible outcomes.
We adopted the provisions of FIN 48 on January 1, 2007. As a result of the implementation of FIN 48, we reclassified $147 million have no expiration date.of unrecognized tax benefits from current liabilities to long-term liabilities as of December 31, 2006. A reconciliation of the beginning and ending amount of unrecognized tax benefits is as follows (in millions):
2008 | 2007 | |||||||
| Balance at beginning of year | $ | 153 | $ | 147 | ||||
| Additions based on tax positions related to the current year | 9 | 1 | ||||||
| Additions for tax positions of prior years | 62 | 5 | ||||||
| Reductions for tax positions of prior years | (13 | ) | – | |||||
| Settlements | (75 | ) | – | |||||
| Balance at end of year | $ | 136 | $ | 153 | ||||
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The total amount of unrecognized tax benefits that, if recognized, would favorably affect our effective income tax rate in a future period was $116 million as of December 31, 2008 and $127 million as of December 31, 2007. We accrue tax-related interest and penalties and include such expenses with income tax expense in the Consolidated Statements of Income. We recognized approximately $14 million and $8 million in tax-related interest expense and penalties during 2008 and 2007, respectively, and had approximately $22 million and $18 million of tax-related interest and penalties accrued at December 31, 2008 and 2007, respectively. Interest amounts are net of tax benefit.
Note 14. | SEGMENT, SIGNIFICANT CUSTOMER AND GEOGRAPHIC INFORMATION |
Our chief operating decision-makers (or “CODMs”)(CODMs) are comprised of our executive management and boardwith the oversight of directors.our Board of Directors. Our CODMs review our operating results and operating plans, and make resource allocation decisions on a company-wide or aggregate basis. Accordingly, we operate as one segment.
Information about our product sales, major customers, and material foreign sources of revenuesrevenue is as follows (in millions):
Product Sales | 2005 | 2004 | 2003 | |||||||
| Net U.S. Product Sales | ||||||||||
| Rituxan | $ | 1,831.4 | $ | 1,574.0 | $ | 1,360.2 | ||||
| Avastin | 1,132.9 | 544.6 | - | |||||||
| Herceptin | 747.2 | 479.0 | 406.0 | |||||||
| Tarceva | 274.9 | 13.3 | - | |||||||
| Xolair | 320.6 | 187.6 | 25.1 | |||||||
| Raptiva | 79.2 | 52.4 | 1.4 | |||||||
| Nutropin products | 370.5 | 348.8 | 319.5 | |||||||
| Thrombolytics | 218.5 | 194.4 | 181.7 | |||||||
| Pulmozyme | 186.5 | 157.1 | 143.7 | |||||||
| Total U.S. product sales | 5,161.7 | 3,551.2 | 2,437.6 | |||||||
| Net product sales to collaborators | 326.4 | 197.7 | 183.8 | |||||||
| Total product sales | $ | 5,488.1 | $ | 3,748.9 | $ | 2,621.4 | ||||
| Product Sales | 2008 | 2007 | 2006 | |||||||||
| Net U.S. Product Sales | ||||||||||||
| Avastin | $ | 2,686 | $ | 2,296 | $ | 1,746 | ||||||
| Rituxan | 2,587 | 2,285 | 2,071 | |||||||||
| Herceptin | 1,382 | 1,287 | 1,234 | |||||||||
| Lucentis | 875 | 815 | 380 | |||||||||
| Xolair | 517 | 472 | 425 | |||||||||
| Tarceva | 457 | 417 | 402 | |||||||||
| Nutropin products | 358 | 371 | 378 | |||||||||
| Thrombolytics | 275 | 268 | 243 | |||||||||
| Pulmozyme | 257 | 223 | 199 | |||||||||
| Raptiva | 108 | 107 | 90 | |||||||||
| Total net U.S. product sales | $ | 9,503 | 8,540 | 7,169 | ||||||||
| Net Product Sales to Collaborators | ||||||||||||
| Avastin | $ | 222 | $ | 157 | $ | 107 | ||||||
| Rituxan | 264 | 230 | 181 | |||||||||
| Herceptin | 437 | 417 | 96 | |||||||||
| Lucentis | 12 | 10 | 1 | |||||||||
| Xolair | – | – | 4 | |||||||||
| Nutropin products | 17 | 12 | 8 | |||||||||
| Thrombolytics | 11 | 20 | 16 | |||||||||
| Pulmozyme | 48 | 43 | 45 | |||||||||
| Raptiva | 17 | 12 | 14 | |||||||||
| Total net product sales to collaborators | 1,028 | 903 | 471 | |||||||||
| Total net product sales | $ | 10,531 | $ | 9,443 | $ | 7,640 | ||||||
________________________
The totals shown above may not appear to sum due to rounding.
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Three of our major customers, customers—AmerisourceBergen Corp.,Corporation, McKesson Corporation, and Cardinal Health, Inc. and McKesson Corp.—which are all national wholesale distributors of all of our major product lines, each contributed 10% or more of our total operating revenuesU.S. product sales in each of the last three years. AmerisourceBergen Corp., a national wholesale distributor of all of our major products lines, represented 36%years, as presented in 2005, 25% in 2004 and 23% in 2003 of our total net U.S. product sales. Cardinal Health, Inc., a national wholesale distributor of all our major product lines, represented 23% in 2005, 17% in 2004 and 18% in 2003 of our total net U.S. product sales. McKesson Corp., a national wholesale distributor of all of our major product lines, represented 23% in 2005, 17% in 2004 and 18% inthe following table.
2008 | 2007 | 2006 | ||||||||||
| AmerisourceBergen Corporation | 49 | % | 55 | % | 50 | % | ||||||
| McKesson Corporation | 23 | % | 17 | % | 17 | % | ||||||
| Cardinal Health, Inc. | 14 | % | 13 | % | 18 | % | ||||||
We currently sell primarily to distributors and health carehealthcare companies throughout the U.S. under an extension of trade credit terms based on an assessment of each customers’ financial condition. Trade credit terms are generally offered without collateral and may include a discount for prompt paymentprompt-payment for specific customers. To manage our credit exposure, we perform ongoing evaluations of our customers’ financial condition and also participate in third partythird-party contracts to significantly reduce the risk of financial loss. In 2005, 20042008, 2007, and 2003,2006, we did not record any material additions to, or losses against, our allowance for bad debts.
Net foreign revenues by country wererevenue, consisting of sales to collaborators, royalty revenue, and contract revenue, was as follows (in millions):
2005 | 2004 | 2003 | ||||||||
| Europe: | ||||||||||
| Switzerland | $ | 319.7 | $ | 234.9 | $ | 210.3 | ||||
| Germany | 79.2 | 47.5 | 33.0 | |||||||
| France | 55.9 | 35.1 | 21.0 | |||||||
| Italy | 34.9 | 22.6 | 15.4 | |||||||
| Great Britain | 33.6 | 23.4 | 13.7 | |||||||
| Spain | 28.0 | 17.6 | 11.3 | |||||||
| Others | 73.3 | 51.1 | 24.6 | |||||||
| Japan | 117.2 | 91.7 | 95.0 | |||||||
| Canada | 39.5 | 27.9 | 22.5 | |||||||
| Others | 90.6 | 44.4 | 30.6 | |||||||
| Total net foreign revenues | $ | 871.9 | $ | 596.2 | $ | 477.4 | ||||
2008 | 2007 | 2006 | ||||||||||
| Switzerland | $ | 1,129 | $ | 983 | $ | 561 | ||||||
| Other foreign countries | 2,241 | 1,327 | 885 | |||||||||
| Total net foreign revenue | $ | 3,370 | $ | 2,310 | $ | 1,446 | ||||||
Net property, plant and equipment by country was as follows (in millions):
2008 | 2007 | 2006 | ||||||||||
| United States | $ | 4,959 | $ | 4,753 | $ | 4,153 | ||||||
| Singapore | 442 | 233 | 20 | |||||||||
| United Kingdom | 3 | – | – | |||||||||
| Total property, plant, and equipment, net | $ | 5,404 | $ | 4,986 | $ | 4,173 | ||||||
QUARTERLY FINANCIAL DATA (UNAUDITED)(unaudited)
(in thousands,In millions, except per share amounts)
2005 Quarter Ended | |||||||||||||
December 31 | September 30 | June 30 | March 31 | ||||||||||
| Total operating revenues | $ | 1,893,095 | $ | 1,751,822 | $ | 1,526,879 | $ | 1,461,578 | |||||
| Product sales | 1,576,964 | 1,450,979 | 1,274,115 | 1,186,002 | |||||||||
Gross margin from product sales(3) | 1,332,050 | 1,214,829 | 999,883 | 930,228 | |||||||||
Net income(1) | 339,239 | 359,413 | 296,166 | 284,174 | |||||||||
| Earnings per share: | |||||||||||||
| Basic | 0.32 | 0.34 | 0.28 | 0.27 | |||||||||
| Diluted | 0.31 | 0.33 | 0.27 | 0.27 | |||||||||
2008 Quarter Ended(1) | ||||||||||||||||
December 31 | September 30 | June 30 | March 31 | |||||||||||||
| Total operating revenue | $ | 3,707 | $ | 3,412 | $ | 3,236 | $ | 3,063 | ||||||||
| Product sales | 2,981 | 2,634 | 2,536 | 2,379 | ||||||||||||
| Gross margin from product sales | 2,478 | 2,225 | 2,095 | 1,990 | ||||||||||||
| Net income | 931 | 731 | 782 | 983 | ||||||||||||
| Earnings per share: | ||||||||||||||||
| Basic | 0.88 | 0.69 | 0.74 | 0.93 | ||||||||||||
| Diluted | 0.87 | 0.68 | 0.73 | 0.92 | ||||||||||||
2004 Quarter Ended | 2007 Quarter Ended(1) | ||||||||||||||||||||||||||||
December 31 | September 30 | June 30 | March 31 | December 31 | September 30 | June 30 | March 31 | ||||||||||||||||||||||
| Total operating revenues | $ | 1,315,300 | $ | 1,202,644 | $ | 1,128,078 | $ | 975,135 | |||||||||||||||||||||
| Total operating revenue | $ | 2,970 | $ | 2,908 | $ | 3,004 | $ | 2,843 | |||||||||||||||||||||
| Product sales | 1,066,302 | 1,005,511 | 913,366 | 763,700 | 2,349 | 2,321 | 2,443 | 2,329 | |||||||||||||||||||||
| Gross margin from product sales | 860,929 | 839,521 | 726,683 | 649,220 | 2,005 | 1,915 | 2,014 | 1,937 | |||||||||||||||||||||
Net income | 206,584 | 230,874 | 170,771 | 176,587 | 632 | 685 | 747 | 706 | |||||||||||||||||||||
| Earnings per share: | |||||||||||||||||||||||||||||
| Basic | 0.20 | 0.22 | 0.16 | 0.17 | 0.60 | 0.65 | 0.71 | 0.67 | |||||||||||||||||||||
| Diluted | 0.19 | 0.21 | 0.16 | 0.16 | 0.59 | 0.64 | 0.70 | 0.66 | |||||||||||||||||||||
| (1) | |
| 9. | CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE |
Not applicable.
| 9A. | CONTROLS AND PROCEDURES |
(a) Evaluation of Disclosure Controls and Procedures: The Company’sOur principal executive and financial officers reviewed and evaluated the Company’sour disclosure controls and procedures (as defined in Exchange Act Rule 13a-15(e)) as of the end of the period covered by this Form 10-K. Based on that evaluation, the Company’sour principal executive and financial officers concluded that the Company’sour disclosure controls and procedures are effective in timely providing them with material information relatingrelated to the Company,Genentech, as required to be disclosed in the reports the Company fileswe file under the Exchange Act.
(b) Management’s Annual Report on Internal Control Over Financial Reporting: The Company’sOur management is responsible for establishing and maintaining adequate internal control over the Company’sour financial reporting. Management assessed the effectiveness of the Company’sour internal control over financial reporting as of December 31, 2005.2008. In making this assessment, management used the criteria set forth by the Committee of Sponsoring Organizations of the Treadway Commission (or “COSO”)(COSO) in Internal Control-Integrated Framework. Based on the assessment using those criteria, management concluded that, as of December 31, 2005,2008, our internal control over financial reporting was effective. The Company’sOur independent registered public accountants, Ernst & Young LLP, audited the consolidated financial statements included in this Annual Report on Form 10-K and have issued an audit report on management’s assessment of our internal control over financial reporting as well as on the effectiveness of
Report of Independent Registered Public Accounting Firm
The Board of Directors and Stockholders of Genentech, Inc.
We have audited management’s assessment, included in the accompanying Management’s Annual Report on Internal Control Over Financial Reporting, that Genentech, Inc. maintained effective’s internal control over financial reporting as of December 31, 2005,2008, based on criteria established in Internal Control—Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (the COSO criteria). Genentech, Inc.’s management is responsible for maintaining effective internal control over financial reporting and for its assessment of the effectiveness of internal control over financial reporting.reporting included in the accompanying Management’s Annual Report on Internal Control Over Financial Reporting. Our responsibility is to express an opinion on management’s assessment and an opinion on the effectiveness of Genentech, Inc.’scompany’s internal control over financial reporting based on our audit.
We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects. Our audit included obtaining an understanding of internal control over financial reporting, evaluating management’s assessment, testing and evaluating the design and operating effectiveness of internal control, and performing such other procedures as we considered necessary in the circumstances. We believe that our audit provides a reasonable basis for our opinion.
A company’s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the company’s assets that could have a material effect on the financial statements.
Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.
In our opinion, management’s assessment that Genentech, Inc. maintained effective internal control over financial reporting as of December 31, 2005, is fairly stated, in all material respects, based on the COSO criteria. Also, in our opinion, Genentech, Inc. maintained, in all material respects, effective internal control over financial reporting as of December 31, 2005,2008, based on the COSO criteria.
We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the consolidated balance sheets of Genentech, Inc. as of December 31, 20052008 and 2004,2007, and the related consolidated statements of income, stockholders’ equity and cash flows for each of the three years in the period ended December 31, 20052008 and our report dated February 4, 2009 (except for the first paragraph of Note 3 and the thirteenth paragraph of Note 10, 2006as to which the date is February 9, 2009) expressed an unqualified opinion thereon.
| /s/ Ernst & Young LLP |
Palo Alto, California
February 10, 20064, 2009
| Item 9B. | OTHER INFORMATION |
Not applicable.
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PART III
| Item 10. | AND CORPORATE GOVERNANCE |
(a) The sections labeled “Nominees for Directors,” “Board Committees and Meetings,” “Audit Committee Matters,” “Corporate Governance”Governance,” and “Section 16(a) Beneficial Ownership Reporting Compliance” of our Proxy Statement in connection with the 20062009 Annual Meeting of Stockholders are incorporated herein by reference.
(b) Information concerning our Executive Officersexecutive officers is set forth in Part I of this Form 10-K.
Item 11. |
The sections labeled “2008 Director Compensation,” “Compensation of Directors,Discussion and Analysis,” “Compensation of Named Executive Officers,” “Summary of Compensation,” “Summary Compensation Table for 2008,” “Stock Option Grants and Exercises,“Grants of Plan Based Awards in 2008,” “Outstanding Equity Awards at Fiscal Year End,” “Option Grants in Last Fiscal Year,Exercises and Stock Vested,” “Aggregated Option Exercises in Last Fiscal Year“Non-Qualified Deferred Compensation for 2008,” and FY-End Option Values,” “Loans and Other Compensation,” “Compensation Committee Interlocks and Insider Participation” of our Proxy Statement in connection with the 20062009 Annual Meeting of Stockholders are incorporated herein by reference.
Item 12. |
The sections labeled “Relationship with Roche,” “Equity Compensation Plans”Plan Information” and “Beneficial Ownership of Principal Stockholders, Directors and Management” of our Proxy Statement in connection with the 20062009 Annual Meeting of Stockholders are incorporated herein by reference.
Item 13. | AND DIRECTOR INDEPENDENCE |
The sections labeled “Relationship with Roche,” “Loans and Other Compensation” and “Certain Relationships and Related Person Transactions” and “Director Independence” of our Proxy Statement in connection with the 20062009 Annual Meeting of Stockholders is incorporated herein by reference.
The section labeled “Audit Committee Matters” and “Principal Accounting Fees and Services” of our Proxy Statement in connection with the 20062009 Annual Meeting of Stockholders is incorporated herein by reference.
(a) The following documents are included as part of this Annual Report on Form 10-K.
1. Index to Financial Statements
Report of Independent Registered Public Accounting Firm
Consolidated Statements of Income for the years ended December 31, 2005, 20042008, 2007, and 20032006
Consolidated Statements of Cash Flows for the years ended December 31, 2005, 20042008, 2007, and 20032006
Consolidated Balance Sheets at December 31, 20052008 and 20042007
Consolidated Statements of Stockholders’ Equity for the year ended December 31, 2005, 20042008, 2007, and 20032006
Notes to Consolidated Financial Statements
Quarterly Financial Data (unaudited)
2. Financial Statement Schedule
The following schedule is filed as part of this Form 10-K:
Schedule II- II–Valuation and Qualifying Accounts for the years ended December 31, 2005, 20042008, 2007, and 2003.2006.
All other schedules are omitted as the information required is inapplicable or the information is presented in the consolidated financial statements or the related notes.
3. Exhibits
The documents set forth below are filed herewith or incorporated by reference to the location indicated.
Exhibit No. | Description | Location | |
3.1 | Amended and Restated Certificate of Incorporation | Filed as an exhibit to our Current Report on Form 8-K filed with the U. S. Securities and Exchange Commission (Commission) on July 28, 1999 and incorporated herein by reference. | |
3.2 | Certificate of Amendment of Amended and Restated Certificate of Incorporation | Filed as an exhibit to our Annual Report on Form 10-K for the year ended December 31, 2000filed with the Commission and incorporated herein by reference. | |
3.3 | Certificate of Amendment of Amended and Restated Certificate of Incorporation | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended June 30, 2001 filed with the Commission and incorporated herein by reference. | |
3.4 | Certificate of Third Amendment of Amended and Restated Certificate of Incorporation | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended June 30, 2004 filed with the Commission and incorporated herein by reference. | |
3.5 | Bylaws | Filed as an exhibit to our Annual Report on Form 10-K for the year ended December 31, 2005 filed with the Commission and incorporated herein by reference. |
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| 4.1 | Indenture, dated as of July 18, 2005, between the Company and Bank of New York, as trustee | Filed on a Current Report on Form 8-K with the Commission on July 19, 2005 and incorporated herein by reference. |
Officers’ Certificate of Genentech, Inc. dated July 18, 2005, including forms of the Company’s 4.40% Senior Notes due 2010, 4.75 Senior Notes due 2015 and 5.25% Senior Notes due 2035 | Filed on a Current Report on Form 8-K with the Commission on July 19, 2005 and incorporated herein by reference. | |
| 4.3 | Form of | Filed on a Current Report on Form 8-K with the Commission on July 19, 2005 and incorporated herein by reference. |
| 4.4 | Form of 4.75% Senior Note due 2015 | Filed on a Current Report on Form 8-K with the Commission on July 19, 2005 and incorporated herein by reference. |
| 4.5 | Form of 5.25% Senior Note due 2035 | Filed on a Current Report on Form 8-K with the Commission on July 19, 2005 and incorporated herein by reference. |
| 10.1 | Form of Affiliation Agreement, dated as of July 22, 1999, between Genentech and Roche Holdings, Inc. | Filed as an exhibit to Amendment No. 3 to our Registration Statement (No. 333-80601) on Form S-3 filed with the Commission on July 16, 1999 and incorporated herein by reference. |
Filed as an exhibit to our Annual Report on Form 10-K for the year ended December 31, 1999 filed with the Commission and incorporated herein by reference. | ||
| 10.3 | Form of Amended and Restated Agreement, restated as of July 1, 1999, between Genentech and F. Hoffmann-La Roche Ltd regarding Commercialization of Genentech’s Products outside the United States | Filed as an exhibit to Amendment No. 3 to our Registration Statement (No. 333-80601) on Form S-3 filed with the Commission on July 16, 1999 and incorporated herein by reference. |
Amendment | ||
Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended June 30, 2004 filed with the Commission and incorporated herein by reference. | ||
| 10.5 | Amendment dated June 26, 2000, to Amended and Restated Agreement between Genentech and F. Hoffmann-La Roche Ltd regarding Commercialization of Genentech’s Products outside the United States | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended June 30, 2004 filed with the Commission and incorporated herein by reference. |
| 10.6 | Third Amendment dated April 30, 2004, to Amended and Restated Agreement between Genentech and F. Hoffmann-La Roche Ltd regarding Commercialization of Genentech’s Products outside the United States | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended June 30, 2004 filed with the Commission and incorporated herein by reference. |
| 10.7 | Form of Tax Sharing Agreement, dated as of July 22, 1999, between Genentech, Inc. and Roche Holdings, Inc. | Filed as an exhibit to Amendment No. 3 to our Registration Statement (No. 333-80601) on Form S-3 filed with the Commission on July 16, 1999 and incorporated herein by reference. |
Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended June 30, 2004 filed with the Commission and incorporated herein by reference. | ||
Genentech, Inc. Tax Reduction Investment Plan, as amended and restated | Filed herewith |
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| 10.10 | ||
Genentech, Inc. 1990 Stock Option/Stock Incentive Plan, as amended effective October 16, 1996 † | Filed as an exhibit to our Registration Statement (No. 333-83157) on Form S-8 filed with the Commission on July 19, 1999 and incorporated herein by reference. |
10.11 | Genentech, Inc. 1994 Stock Option Plan, as amended effective October 16, 1996 † | Filed as an exhibit to our Registration Statement (No. 333-83157) on Form S-8 filed with the Commission on July 19, 1999 and incorporated herein by reference. | |
10.12 | |||
Genentech, Inc. 1999 Stock Plan, as amended and restated as of February 13, 2003 † | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended March 31, 2003 filed with the Commission and incorporated herein by reference. | ||
Genentech, Inc. 1999 Stock Plan, Form of Stock Option Agreement † | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended September 30, 2004 filed with the Commission and incorporated herein by reference. | ||
Genentech, Inc. 1999 Stock Plan, Form of Stock Option Agreement (Director Version)† | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended September 30, 2004 filed with the Commission and incorporated herein by reference. | ||
Genentech, Inc. 2004 Equity Incentive Plan † | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended March 31, 2004 filed with the Commission and incorporated herein by reference. | ||
Form of Genentech, Inc. | Filed as an exhibit to our Annual Report on Form 10-K for the year ended December 31, | ||
Form of Genentech, Inc. 2004 Equity Incentive Plan Nonqualified Stock Option Grant Agreement (Director Version) † | Filed on a Current Report on Form 8-K with the Commission on September 26, 2006, and incorporated herein by reference. | ||
| 10.18 | Genentech, Inc. Supplemental Plan † | Filed on a Current Report on Form 8-K with the Commission on February 24, 2005 and incorporated herein by reference. | |
10.19 | Amendment No. 1 to the Genentech, Inc. Supplemental Plan | Filed herewith | |
| 10.20 | Amendment No. 2 to the Genentech, Inc. Supplemental Plan | Filed herewith | |
| 10.21 | Amendment No. 3 to the Genentech, Inc. Supplemental Plan | Filed herewith | |
| 10.22 | Genentech, Inc. 1991 Employee Stock Plan, as amended | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended June 30, 2008, filed with the Commission on August 5, 2008, and incorporated herein by reference. | |
| 10.23 | Bonus | Incorporated by reference to the description under “Bonus Program” in the Current Report on Form 8-K filed with the Commission on February 19, 2009. | |
Form of Indemnification Agreement for Directors and Officers † | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended March 31, 2005 filed with the Commission and incorporated herein by reference. | ||
Filed on a Current Report on Form 8-K with the Commission on August | |||
| Filed on a Current Report on Form 8-K with the Commission on August 21, 2008, and | |||
Master Lease Agreement dated as of November 1, 2004, between Genentech and Slough SSF, LLC | Filed as an exhibit to our Annual Report on Form 10-K for the year ended December 31, 2004 filed with the Commission and incorporated herein by reference. |
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Filed as an exhibit to our Annual Report on Form 10-K for the year ended December 31, 2006 filed with the Commission and incorporated herein by reference. | ||
| 10.29 | Second Amendment to Master Lease Agreement between Genentech and HCP SSF, LLC (formerly Slough SSF, LLC) dated April 8, 2008 | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended June 30, |
Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended | ||
Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended | ||
| 10.32 | Agreement and Plan of Merger by and among Genentech, Inc., Green Acquisition Corporation and Tanox, Inc., dated as of November 9, 2006 | Filed as an exhibit to our Annual Report on Form 10-K for the year ended December 31, |