1

2

3

In this report, “Bio-Rad,” “we,” “us,” and “our” refer to Bio-Rad Laboratories, Inc. and its subsidiaries.  The accompanying unaudited condensed consolidated financial statements of Bio-Rad have been prepared in accordance with accounting principles generally accepted in the United States of America and reflect all adjustments which are, in the opinion of management, necessary to fairly state the results of the interim periods presented.  All such adjustments are of a normal recurring nature.  Results for the interim period are not necessarily indicative of the results for the entire year.  The condensed consolidated financial statements should be read in conjunction with the notes to the consolidated financial statements contained in our Annual Report for the year ended December 31, 2004.  Certain prior year items have been reclassified to conform to the current year
46;s presentation.

Restricted cash of $35.6$35.8 million represents deposits in a money market account that have been used as collateral to protect the surety company in connection with its execution of a surety bond in the amount of $37.2 million to stay the enforcement of the judgment in the legal matter described in Note 17.

Short-term investments consist of the following (in millions):

Short-term investments consist of securities with readily determinable fair market values and original maturities in excess of three months and are available for use in current operations or other activities such as capital expenditures or acquisitions.  Short-term investments in debt and equity securities are accounted for in accordance with Statement of Financial Accounting Standards (SFAS) No. 115, “Accounting for Certain Investments in Debt and Equity Securities.”  Management has classified these short-term investments as “Available for Sale”“Available-for-Sale” and as such, unrealized gains and losses are included as a separate component of accumulated other comprehensive income or (loss), net of any related tax effect.

6.

GOODWILL AND OTHER PURCHASED INTANGIBLE ASSETS4

In March

The principal components of inventories are as follows (in millions):

The principal components of property, plant and equipment are as follows (in millions):

Net capital expenditures include proceeds from the sale of property, plant and equipment of $3.3 million and $1.0 million for the nine months ended September 30, 2005 we purchased the rights to certain patents for $1.0 million.  These intangible assets are included in the Clinical Diagnostics segment.and 2004, respectively.

Other than goodwill, we have no intangible assets with indefinite lives.  Information regarding our identifiable purchased intangible assets is as follows (in millions):

5

Recorded intangible asset amortization expense for the three months ended JuneSeptember 30, 2005 and 2004 was $2.8$2.7 million and $0.8$1.8 million, respectively.  Recorded intangible asset amortization expense for the sixnine months ended JuneSeptember 30, 2005 and 2004 was $5.6$8.3 million and $2.2$3.9 million, respectively. Estimated intangible asset amortization expense (based on existing intangible assets) for the years ended December 31, 2006, 2007, 2008, 2009, and 2010 is $10.3 million, $10.0$9.9 million, $8.7

$8.6 million, $5.8$5.7 million and $2.4$2.3 million, respectively.

At JuneSeptember 30, 2005, we owned slightly less thanapproximately 25% of the outstanding voting shares of Sartorius AG (Sartorius), of Goettingen, Germany, a process technology supplier to the biotechnology, pharmaceutical, chemical and food and beverage industries.  The Sartorius family trust and Sartorius family members hold approximately 60%a controlling interest of the outstanding voting shares.  Bio-Rad does not have any representative or designee on Sartorius’ board of directors, nor does it have any other influence over the operating and financial policies of Sartorius.  Therefore, we account for this investment using the cost method.

On May 31, 2004, we sold a group of assets and transferred certain liabilities that comprise a substantial portion of our confocal microscopy product line to Carl Zeiss Jena GmbH.  As required by SFAS 144, “Accounting for the Impairment or Disposal of Long-Lived Assets,” with the disposition of this asset group, the sales and expenses related to this product line for current and prior periods have been reclassified as a separate line on the income statement titled “Discontinued Operations.”

6

Since the discontinued operations were sold in the second quarter of 2004, there were no sales or operating losses in the sixnine months ended JuneSeptember 30, 2005.  However, during the priorfirst quarter of 2005, we reached an agreement to settle the $6.7 million estimated lease commitment that comprised the most significant portion of the original shut-down provision.  We have revised our estimate based on that settlement agreement, and now require only required $1.6 million to exit the facility during 2005.  Consequently, in the first quarter of 2005, we recognized a $4.0 million gain on the revised disposition of the confocal microscopy product line, net of cash payments and reserve requirements.

The discontinued operations generated net sales of $3.9 millionzero and $6.3 million for the three months and sixnine months ended JuneSeptember 30, 2004, respectively.  The pre-tax operating losses attributable to the discontinued operations for the three months and sixnine months ended JuneSeptember 30, 2004 were $1.2 millionzero and $2.0 million, respectively.

6

Bio-Rad warrants certain equipment against defects in design, materials and workmanship, generally for one year.  Upon shipment of that equipment, we establish, as part of cost of goods sold, a provision for the expected cost of such warranty.

Components ofChanges in the product warranty liability included in other current liabilities and other long-term liabilities were as follows (in millions):

In June 2005, Bio-Rad entered into a new Credit Agreement, which amends and restates the Credit Agreement dated September 9, 2003, as amended December 8, 2004.  Borrowings are permitted up to a maximum of $150.0 million on a revolving basis and can be used to make acquisitions, for working capital and other general corporate purposes.  ThisUnder certain conditions, this Credit Agreement may be increased up to an additional $50 million and will mature on June 21, 2010.

In December 2004, Bio-Rad sold $200.0 million principal amount of Senior Subordinated Notes due 2014 (6.125% Notes).  The notes pay a fixed rate of interest of 6.125% per year.  Bio-Rad has the right to repurchase up to 35% of the 6.125% Notes any time prior to December 15, 2007 upon any sale of Bio-Rad’s common stock at a specified redemption price plus accrued and unpaid interest and certain other charges.  Furthermore, Bio-Rad has the option to redeem any or all of the 6.125% Notes at various declining redemption prices or at 100% of the principal amount plus the “applicable premium” (as defined by the indenture) along with accrued and unpaid interest and certain other charges depending on the date redeemed.  Bio-Rad’s obligations under the 6.125% Notes are not secured, rank equal to other senior subordinated notes and rank junior to all Bio-Rad’s existing and future senior debt.

7

In August 2003, Bio-Rad sold $225.0 million principal amount of Senior Subordinated Notes due 2013 (7.5% Notes).  The notes pay a fixed rate of interest of 7.5% per year.  Bio-Rad has the right to repurchase up to 35% of the 7.5% Notes any time prior to August 15, 2006 upon any sale of Bio-Rad’s common stock at a specified redemption price plus accrued and unpaid interest and certain other charges.  Furthermore, Bio-Rad has the option to redeem any or all of the 7.5% Notes at various declining redemption prices or at 100% of the principal amount plus the “applicable premium” (as defined by the indenture) along with accrued and unpaid interest and certain other charges depending on the date redeemed. Bio-Rad’s obligations under the 7.5% Notes are not secured, rank equal to other senior subordinated notes and rank junior to all ourBio-Rad’s existing and future senior debt.

7

We calculate basic earnings per share (EPS) and diluted EPS in accordance with SFAS No. 128, "Earnings Per Share."  Basic EPS is computed by dividing net income (loss) by the weighted average number of common shares outstanding for that period.  Diluted EPS takes into account the effect of dilutive instruments, such as stock options, and uses the average share price for the period in determining the number of common stock equivalents that are to be added to the weighted average number of shares outstanding.  Common stock equivalents are excluded from the diluted earnings per share calculation if the effect would be anti-dilutive.

Weighted average shares used for diluted earnings per share include the dilutive effect of outstanding options to purchase 590,000580,000 and 805,000718,000 shares of stock for the three months ended JuneSeptember 30, 2005 and 2004, respectively.  Options to purchase 603,000308,000 and 5,000305,000 shares of common stock were outstanding during the three months ended JuneSeptember 30, 2005 and 2004, respectively, but were excluded from the computation of diluted earnings per share because the exercise price of the options was greater than the average market price of the common shares.

Weighted average shares used for diluted earnings per share include the dilutive effect of outstanding options to purchase 618,000605,000 and 812,000780,000 shares of stock for the sixnine months ended JuneSeptember 30, 2005 and JuneSeptember 30, 2004, respectively.  There were 540,000272,000 and 4,0009,000 anti-dilutive options for the sixnine months ended JuneSeptember 30, 2005 and 2004, respectively.

In December 2004, the Financial Accounting Standards Board issued SFAS 123 (revised 2004), “Share-Based Payment.”  This statement requires all share-based payments to employees, including grants of employee stock options, to be recognized in the financial statements based on their fair values.  Currently, companies are required to calculate the estimated fair value of these share-based payments and can elect to either include the estimated cost in earnings or disclose the pro forma effect in the footnotes to their financial statements.  SFAS 123R replaces SFAS 123, “Accounting for Stock-Based Compensation,” and supersedes APB Opinion No. 25, “Accounting for Stock Issued to Employees.”  Upon adoption, the pro forma disclosures previously permitted under SFAS 123 will no longer be an alternative to financial statement recognition.  We are required to adopt SFAS 123R beginning Januar y 1, 2006.  We are currently evaluating the impact of adoption of this statement.

Stock Option Plans

Bio-Rad maintains incentive and non-qualified stock option plans for officers and certain other key employees.  Under the 2003 Stock Option Plan, options to purchase 307,822 shares and 306,990 shares were granted during the sixnine months ended JuneSeptember 30, 2005 and JuneSeptember 30, 2004, respectively.  No options have been issued to non-employees.

Bio-Rad applies the recognition and measurement principles of APB Opinion No. 25, "Accounting for Stock Issued to Employees," and related interpretations in accounting for those plans.  No stock-based employee compensation expense is reflected in net income as all options granted under those plans had an exercise price equal to or greater than the market value of the underlying common stock on the date of grant.

8

Had compensation cost for Bio-Rad's stock option and stock purchase plans been accounted for under SFAS No. 123, "Accounting for Stock-Based Compensation," Bio-Rad's pro forma net income and earnings per share would have been as follows (in millions, except per share data):

Employee Stock Purchase Plan

Bio-Rad has an employee stock purchase plan that provides that eligible employees may contribute up to 10% of their compensation up to $25,000 annually toward the quarterly purchase of shares of Bio-Rad’s Class A common stock.  The employees’ purchase price is 85% of the lesser of the fair market value of the stock on the first business day or the last business day of each calendar quarter.  No compensation expense is recorded in connection with the plan.  At JuneSeptember 30, 2005, Bio-Rad has authorized the sale of 2,390,000 shares of common stock under the plan.

Bio-Rad sold 21,33726,556 shares for $0.9$1.1 million and 14,72918,678 shares for $0.7$0.9 million under the plan to employees for the three months ended JuneSeptember 30, 2005 and 2004, respectively.  Bio-Rad sold 43,39969,955 shares for $1.9$3.0 million and 32,00250,680 shares for $1.5$2.3 million under the plan to employees for the sixnine months ended JuneSeptember 30, 2005 and 2004, respectively.  At JuneSeptember 30, 2005, 630,352 shares remain authorized shares under the plan remain at 656,908.plan.

In December 2004, the Financial Accounting Standards Board issued SFAS 123 (revised 2004), “Share-Based Payment.”  This statement requires all share-based payments to employees, including grants of employee stock options, to be recognized in the financial statements based on their fair values.  Currently, companies are required to calculate the estimated fair value of these share-based payments and can elect to either include the estimated cost in earnings or disclose the pro forma effect in the footnotes to their financial statements.  SFAS 123 (R) replaces SFAS 123, “Accounting for Stock-Based Compensation,” and supersedes APB Opinion No. 25, “Accounting for Stock Issued to Employees.”  Upon adoption, the pro forma disclosures previously permitted under SFAS 123 will no longer be an alternative to financial statement recognition.  We are required to adopt SFAS 123 (R) beginning January 1, 2006.  We are currently evaluating the impact of adoption of this statement.

9

Exchange gains and losses consist of foreign currency transaction gains and losses on intercompany net receivables and payables and the change in fair value of our forward foreign exchange contracts used to manage our foreign exchange risk.

9

Other (income) expense, net, includes the following components (in millions):

The sixnine months ended JuneSeptember 30, 2004 includes $2.4 million of expense for an other-than-temporary impairment of equity interest in Instrumentation Laboratory, S.p.A., which is accounted for using the cost method.  See Note 18 (Subsequent Events).

SFAS No. 130, "Reporting Comprehensive Income" requires disclosure of total non-stockholder changes in equity, which include unrealized gains and losses on securities classified as available-for-sale under SFAS No. 115, "Accounting for Certain Investments in Debt and Equity Securities," foreign currency translation adjustments accounted for under SFAS No. 52, "Foreign Currency Translation" and minimum pension liability adjustments made pursuant to SFAS No. 87, "Employers' Accounting for Pensions."

The components of Bio-Rad’s total comprehensive income were (in millions):

10

Information regarding industry segments for the three months ended JuneSeptember 30, 2005 and 2004 is as follows (in millions):

10

Information regarding industry segments for the sixnine months ended JuneSeptember 30, 2005 and 2004 is as follows (in millions):

Segment results are presented in the same manner as we present our operations internally to make operating decisions and assess performance.  Net corporate operating income (expense) consists of receipts and expenditures that are not the primary responsibility of segment operating management.  Interest expense is charged to segments based on the carrying amount of inventory and receivables employed by that segment.  The following reconciles total segment profit to consolidated income from continuing operations before taxes (in millions):

11

Applera Corporation (Applera) and Roche Molecular Systems (Roche) filed a patent infringement case against MJ Research, Inc. and John and Michael Finney in the U.S. District Court for the District of Connecticut in June 1998. On August 18, 2004, we acquired MJ Research through the acquisition of 100% of the stock of its parent company, MJ GeneWorks, Incorporated, from John and Michael Finney. The complaint alleges that MJ Research is infringing certain patents relating to Polymerase Chain Reaction (PCR) and instruments for performing PCR. In response to their claims, MJ Research filed counterclaims including, among others, allegations that Applera had licensed and enforced these patents through anticompetitive conduct in violation of federal and state antitrust laws. A trial on these matters commenced in March 2004.  The Court elected to hold the trial in two phases: a patent phase and an antitrust phase.

11

In the patent phase, which has concluded, the jury found that MJ Research infringed three U.S. patents related to PCR process technology and three U.S. patents related to thermal cycler instrument technology. The jury found the infringement of four of the six patents to be willful. MJ Research filed for Chapter 11 bankruptcy protection in the U.S. Bankruptcy Court for the District of Nevada on March 29, 2004, and later, the Bankruptcy Court granted MJ Research’s motion to dismiss the bankruptcy case, which became final in September 2004.

In April 2004, the jury awarded damages to Applera and Roche in the amount of $19.8 million. Applera and Roche sought an enhancement of damages, including legal fees, since several infringements were found to be willful. On March 30, 2005, the Court granted Applera’s and Roche’s motion for enhancement of damages and increased the damages awarded to $35.4 million in addition to awar dingawarding reasonable attorneys’ fees and costs in an amount yet to be determined by the Court. On March 31, 2005 the Court entered judgment in favor of Applera and Roche in that amount, subject to later amendment after it awards attorneys’ fees and costs. In connection with this ruling, in April we posted a surety bond in the amount of $37.2 million collateralized by the restricted cash of $35.6$35.8 million to stay the enforcement of the judgment pending appeal.  The bond amount will be amended to reflect attorneys’ fees or interest , as necessary.

Regarding the antitrust phase of the trial, the Court ruled against MJ Research on all of its patent misuse defenses and federal antitrust counterclaims and dismissed all of its counterclaims, including the state antitrust and unfair competition claims, based on those rulings.  The Court denied MJ Research’s motion for reconsideration of the Court’s ruling on patent misuse. On April 1, 2005, Applera moved the Court for entry of a permanent injunction on the asserted claims of the three U.S. patents related to thermal cycler instrument technology. On April 14, 2005, MJ Research and John and Michael Finney filed a notice of appeal to the United States Court of AppealAppeals for the Federal Circuit. In addition, they filed several post-judgment motions, including a motion for a new trial and a motion for judgment as a matter of law.  Applera has filed a motion to amend the judgment to include prejudgment interest i n thein t he amount of approximately $1.0 million. .  On May 13, 2005, Applera also moved the Court for joinder of Bio-Rad as an additional defendant in the case.  We are opposingopposed to the motion for joinder and the motion for entry of a permanent injunction.  In connection with these matters, we have established a $50.0 million litigation accrual.

On August 25, 2005, the Court denied MJ Research’s and Michael and John Finney’s motion for a new trial and their motion for judgment as a matter of law.  On August 29, 2005, the Court granted Applera’s motion to amend the judgment to include prejudgment interest in the amount of approximately $0.9 million.  On August 30, 2005, the Court granted Applera’s motion for entry of a permanent injunction but denied Applera’s motion for joinder of Bio-Rad as an additional defendant in the case.  The injunction ruling, among other things, enjoins MJ Research, Michael and John Finney and, among others, MJ Research’s successors (which includes Bio-Rad) from making, using, offering to sell, or selling in the U.S. any products that were found at trial to directly infringe certain claims of two of the three U.S. patents held by Applera relating to thermal cycler instrument technology.  The injunctio n further enjoins them from contributing to the infringement of these claims by selling, offering to sell, or importing into the U.S. any products found at trial to infringe and from inducing others to infringe certain claims of all three of the U.S. patents relating to thermal cycler instrument technology.  Bio-Rad has taken action to comply with and believes it is now fully complying with this injunction.

12

On August 30, 2005, Bio-Rad entered into what it believes was an enforceable settlement agreement with Applera and Roche to settle this and all other pending litigation among the parties.  On Friday, September 2, 2005, Bio-Rad issued a press release in response to Applera’s September 1, 2005 press release regarding the injunction, in which Bio-Rad stated its belief that the parties had reached a settlement.  

On September 8, 2005, Bio-Rad filed a motion with the Court to enforce the settlement agreement and for an award of attorneys’ fees and costs.  In addition, on September 30, 2005, Bio-Rad filed a motion to stay the injunction pending a favorable ruling on its motion to enforce the settlement agreement or, if that motion is not granted, a decision by the Court of Appeals for the Federal Circuit on the appeal of the judgment.  Applera and Roche are opposing these motions.  On September 12, 2005, Applera filed motion to hold MJ Research and Bio-Rad in contempt for allegedly violating the injunction.  MJ Research and Bio-Rad are opposing this motion.

Applera also filed four actions in the Regional Court of Düsseldorf, Germany during the period from August 2002 through September 2003 against MJ Research and others alleging infringement of four European patents relating to thermal cyclers. We are also a defendant in one of the actions.  The suit seeks actual damages, costs and expenses and injunctive relief. Three of the actions had a trial before the Düsseldorf court in April 2004. One of these actions has since been dismissed. In May 2004, the Düsseldorf court issued an adverse ruling against MJ Research and us, which included an injunction against us and MJ Research from selling any real-time PCR instruments and reagents in Germany. In December 2004, the European Patent Office revoked the patent and the injunctions against MJ Research and Bio-Rad were lifted, allowing MJ Research and us to resume sales of real-time PCR thermal cyclers and reagents. In another of th esethese actions, the Düsseldorf court rendered an adverse decision against MJ Research in April 2005. A decision on a separate action concerning Applera’s European patent relating to automated performance of PCR is pending.

We are also a defendant in an action in Japan which is similar to the action concerning the revoked European patent relating to real-time PCR. Applera commenced this action against us on May 7, 2002. The complaint alleges that we are infringing a Japanese patent which is a counterpart to the revoked European patent and seeks injunctive relief but not damages.  In November 2003, the Japanese court issued an adverse ruling against us which enjoined us from selling real-time PCR instruments and reagents in Japan. We appealed the decision and also filed a separate action in the Japanese Patent Office seeking revocation of the Japanese patent.  In March 2005, the Japanese Patent Office revoked the Japanese patent.

Bio-Rad and MJ Research are also defendants in an action in the U.S. District Court for the District of Connecticut which is similar to the action concerning the European real-time PCR patent. Applera commenced the action against us on November 9, 2004. The complaint alleges that we are infringing a U.S. patent which is a counterpart to the revoked European real-time PCR patent.  The complaint seeks damages and injunctive relief.

We are also party to various claims, legal actions and complaints arising in the ordinary course of business. We do not believe that any ultimate liability resulting from any of these lawsuits will have a material adverse effect on our results of operations, financial position or liquidity. However, we cannot give any assurance regarding the ultimate outcome of these lawsuits and their resolution could be material to our operating results for any particular period, depending upon the level of income for the period.

13

On July 26, 2005, BioSource International, Inc (BioSource) announced in a press release that it had entered into a definitive merger agreement under which Invitrogen Corporation will acquire BioSource for $12.50 per share in cash   At September 30, 2005, we owned 665,639 shares of the outstanding shares of BioSource.  In October 2005, we tendered our shares of BioSource to Invitrogen Corporation for $12.50 per share in cash and received cash of approximately $8.3 million.

At September 30, 2005, Bio-Rad owned 12,164,237 shares of Instrumentation Laboratory, S.p.A.  On October 6, 2005, we entered into an agreement to sell all the shares back to Instrumentation Laboratory, S.p.A.  In October, we received cash of approximately $12.0 million

A pre-tax gain on these transactions of approximately $11 million will be recorded in other income in the fourth quarter of 2005.

Item 2.

Management’s Discussion and Analysis of Results of Operations

and Financial Condition.

This discussion should be read in conjunction with the information contained in both our Consolidated Financial Statements for the year ended December 31, 2004 and this report for the quarter and sixnine months ended JuneSeptember 30, 2005.

Other than statements of historical fact, statements made in this report include forward looking statements, such as statements with respect to Bio-Rad’s future financial performance, operating results, plans and objectives that involve risk and uncertainties.  We have based these forward looking statements on our current expectations and projections about future events.  However, actual results may differ materially from those currently anticipated depending on a variety of risk factors including among other things: our ability to successfully develop and market new products; our reliance on and access to necessary intellectual property; our ability to service our debt; competition in and government regulation of the industries in which we operate; and the monetary policies of various countries.  We undertake no obligation to publicly update or revise any forward looking statements, whether as a result of new info rmation, future events, or otherwise.

Overview.  We are a multinational manufacturer and worldwide distributor of Life Sciencelife science research and Clinical Diagnosticsclinical diagnostics products.  Our business is organized into two primary segments, Life Science and Clinical Diagnostics, with the mission to provide scientists with specialized tools needed for biological research and clinical diagnostics.  We sell more than 8,000 products and services to a diverse client base comprised of scientific research, healthcare, industry, education and government customers worldwide. We manufacture and supply our customers with a range of reagents, apparatus and equipment to separate complex chemical and biological materials and to identify, analyze and purify components.  Because our customers require replication of results from experiments and tests, we estimate that approximately 70% of our revenues are recurring.  Approximately 37% of our secondthird quarter 2005 consolidated net s alessa les are from the United States and approximately 63% are international sales largely denominated in local currency with the majority of these sales in Euros, Yen and British Pound Sterling. As a result, our consolidated sales expressed in dollars benefit when the US dollar weakens and suffer when the dollar strengthens in relation to other currencies.  Currency fluctuations benefited our consolidated sales expressed in US dollars in the current quarter ended JuneSeptember 30, 2005 as well as in the prior year.

14

On a currency neutral basis, the diagnostic market is growing around 3% comprised of specialty areas experiencing significant growth offset by flat to declining growth in the routine testing market.  Pricing for routine diagnostic tests is impacted by government reimbursement schedules, particularly in the US, Japan, and Germany.

The overall average growth of the life science market is currently about 5% on a currency neutral basis.  Some spending on government sponsored research has slowed or is being deferred especially in the US and Japan.  Large capital instrumentation systems sales continue to lag the overall growth rate.  Reagent sales are rising faster than the average growth.  The market for BSE tests continues to be very dynamic as countries with established countriestesting programs consolidate testing sites and new competitors enter the market, resulting in competitive pricing pressures and lower average selling prices per test.  Growth in BSE will come only from new testing markets.  Current BSE testing levels are largely dependantdependent on government mandates to safeguard the respective country’s beef supply.

14

The following shows gross profit and expense items as a percentage of net sales:

Critical Accounting Policies

As previously disclosed in our Annual Report on Form 10-K for the year ended December 31, 2004, we have identified accounting for income taxes, valuation of long-lived and intangible assets and goodwill, valuation of inventories, allowance for doubtful accounts, litigation reserves, and warranty reserves as the accounting policies critical to the operations of Bio-Rad. For a full discussion of these policies, please refer to our Form 10-K for the period ended December 31, 2004.

15

Three Months Ended JuneSeptember 30, 2005 Compared to

Three Months Ended JuneSeptember 30, 2004

Corporate Results --– Sales, Margins and Expenses

Net sales (sales) in the secondthird quarter of 2005 rose 11.8%9.4% to $291.3$283.2 million from $260.5$258.8 million in the secondthird quarter of 2004. The positive impact to sales from a weakening US dollar represented $8.7$2.6 million. For Bio-Rad in total, on a currency neutral basis, secondthird quarter 2005 sales grew 8.5%8.4% compared to the secondthird quarter of 2004.  The Clinical Diagnostics segment sales grew by 7.5%8.7% before adjustment to a currency neutral basis, while the Life Science segment sales grew 16.9%.9.5% before currency adjustment.  On a currency neutral basis, Clinical Diagnostics segment sales growth was 4.1%7.5%, while Life Science segment sales grew 13.7%8.7%.  Each product group of the Clinical Diagnostics segment contributed to sales were driven by its quality control product line, blood virus, and diabetes products.growth.  Life Science segment sales experienced growth in the protein expression product lines due, in part, to the recent acquisition of MJ GeneWorks, Inc., and also in our amplification, electrophores iselectrophoresis reagent, multianalytemultianalyt e detection, core imaging and BioEducation products.  Sales declined for food science products in the very competitive BSE market, as average selling prices continuedeclined compared to decline and deliveries declined as the number of tenders awarded were lower in the current quarter.  Life Science segment sales for the second quarter of 2004 have been presented net of the confocal microscopy product line, which was recorded as discontinued operations in 2004.

15

prior period.

Consolidated gross margins were 55.1%55.4% for the secondthird quarter of 2005 compared to 57.4%55.2% for the secondthird quarter of 2004 and 56.0% for all of 2004.  Clinical Diagnostics segment gross margins improved by approximately 0.5%1.6% when compared to the secondthird quarter of 2004.  The improvements in 2005 reflect lower requirements for inventory provisions, offset by overall higher service costs and warehouse expenses.  Also included in 2004 and absent in 2005 was a freight refund to a hospital purchasing group.

Life Science segment margins declined by approximately 6%1.4% on lower average selling prices for the BSE test, increased amortization of intangibles from the acquisition of MJ GeneWorks, Inc., and increased inventory provisions for automated BSE equipment designatedwarranty expenses as the Company has increased its obligations for the North American market which is not performing a sufficient number of testsshort term to makeaccommodate its customers, while the equipment economically viable.MJ products covered by the injunction cannot be serviced and Bio-Rad products are being offered in the short term.

Selling, general and administrative expenses (SG&A) represented 35.8%36.3% of sales for the secondthird quarter of 2005 compared to 34.6%34.8% of sales for the secondthird quarter of 2004.  Both Clinical Diagnostics andSG&A core spending increased in line with sales growth after adjusting the prior period for increased bad debt reserves in Latin America which did not occur this period.  Life Science segments increased SG&A expense at a rate of growth in excess of sales.  Increased spending for the Life Science segment reflects additional litigation costs, amortization of intangibles from the MJ Research intangiblesacquisition, personnel expenses, thirdparty commissions and an increase in the provisionallowance for uncollectible receivables.doubtful accounts.

Product research and development expense, increased 11.6%after adjusting for purchased in process research and development associated with the MJ Research acquisition in 2004, rose from $26.6 million to $28.5 million in the second quarter 2005.  Both Life Science and$28.7 million.  Clinical Diagnostics segments increased expenditures with Clinical Diagnostics segment growing faster than sales growth andgrowth.  Life Science at a rate below sales growth.  Beginning in 2005, a Corporate sponsored external project was transferredspending remained constant compared to Life Science.  This amount was previously reported as a Corporate net operating expense not allocated to segments.the prior year.  Corporate presently has no R&Dresearch and development expense included in its 2005 costs not allocated to the segments.  Areas of development for the Life Science segment are proteomics, process chromatography, and food safety.  Diagnostic development efforts are focused on expanded tests for its BioplexBio-Plex 2200^TMtesting platform, as well as enhancements to existing product offerings in diabetes monitoring, blood virus diagnostics and cl inicalclinical microbiology.

16

Corporate Results – Other Items

Interest expense increased from the secondthird quarter 2004 by $3.1$3.2 million.  Average indebtedness increased from $234.8$237.2 million in the secondthird quarter of 2004 to $435.9$435.8 million in the secondthird quarter of 2005.  The interest increase reflects costs on the $200 million 6.125% Subordinated Debt placed in December 2004.

Exchange gains and losses consist of foreign currency transaction gains and losses on intercompany net receivables and payables and the change in fair value of our forward foreign exchange contracts used to manage our foreign exchange risk.  During the quarter, weexperienced incremental gains on foreign exchange from the unhedged portion ofgains on our Brazilian subsidiary’s net intercompany payables as the Brazilian Real strengthened appreciably against the Euro and US dollar.

Other income and expense for the secondthird quarter of 2005 increased compared to the secondthird quarter of 2004 as investment income, including interest, rose as we invested an incremental $200 million in short-term investments and cash equivalents – the proceeds of the December $200 million Subordinated Debt.  Also included in other income and expense are gains orand losses associated with the sale of surplus manufacturing or other productive assets.

16

Bio-Rad’s effective tax rate was 28%22% and 31% for the secondthird quarter of 2005 and 2004, respectively.  The reduction in tax rate resulted from an increase in the benefit of foreign organizational efficiencies.restructuring, an increase in the benefit for the reduction in the valuation allowance for foreign deferred tax assets, adjustments necessary to reflect actual tax liabilities and other miscellaneous items.

Our effective tax rate may be impacted in the future, either favorably or unfavorably, by many factors including but not limited to statutory tax rates, changes in existing laws or regulations, tax audits and settlements, and generation of tax credits.

On August 30, 2005, the Federal District Court in Connecticut granted a permanent injunction in our ongoing litigation with Applera and Roche.  Among other things, the injunction prevents us from selling the MJ Research line of thermal cycling products that we acquired in August 2004 in the United States.  However, Bio-Rad believes that a settlement agreement with Applera and Roche had been reached and Bio-Rad has made motions to the court asking that the settlement agreement be enforced and requesting a stay of the injunction during an appeal.  Although the timing and outcome of these motions are uncertain at this time, if the injunction continues in place throughout the fourth quarter, our Life Science segment could be negatively impacted with sales being reduced by as much as $10 to $15 million and pre-tax operating profit reduced by $8 to $10 million versus prior expectations.

17

Nine months Ended September 30, 2005 Compared to

Nine months Ended September 30, 2004

Corporate Results – Sales, Margins and Expenses

Net sales (sales) in the nine months ended 2005 rose 11.7% to $873.7 million from $782.1 million in the nine months ended 2004.  The positive impact to sales from a weakening US dollar represented $21.1 million. For Bio-Rad in total, on a currency neutral basis, sales grew 9.0% compared to the prior period.  Before adjustment to a currency neutral basis, the Clinical Diagnostics segment sales grew by 8.5% to $455.5 million and the Life Science segment sales grew 14.9% to $409.3 million.  On a currency neutral basis, the Clinical Diagnostics segment’s sales increased 5.6% and the Life Science segment’s sales grew 12.4%.  Each of the Clinical Diagnostic product lines has contributed to the segment’s overall sales growth.  Life Science segment sales growth is attributable to the MJ acquisition as well as established products including multiplex protein array technology, process chromatography and e lectrophoresis product lines.  Life Science segment sales declined for food science products as our BSE test faces competitive pricing pressure which has resulted in a lower average selling price, and a decline in the number of tests as some governments have relaxed their criteria for testing.

Consolidated gross margins were 55.4% for the nine months ended 2005 compared to 56.5% for the nine months ended 2004 and 56.0% for all of 2004.  The Life Science segment gross margin decline is primarily due to declining BSE sales and increased costs from amortization of intangibles associated with the MJ acquisition.  Diagnostic margins have improved on lower provisions for obsolete inventory from the prior period, and a reduction in factory overhead offset by higher service costs.

Selling, general and administrative expenses (SG&A) represented 35.1% of sales for the nine months ended 2005 compared to 34.2% of sales in the prior year period.  The Life Science segment has increased spending at a rate in excess of sales growth.  Clinical Diagnostics is increasing at the rate of sales growth.  Expenses contributing to this overall increase include personnel costs and legal fees, the amortization of recently acquired intangibles, consulting fees related to information technology infrastructure, and third party commissions.

Product research and development expense increased 9.9% to $84.0 million in the nine months ended 2005 compared to the same period in 2004 after excluding $14.6 million of expense for acquired in-process research and development in the same period of 2004 associated with our acquisitions of Hematronix and MJ Research.  The Clinical Diagnostics segment accounted for most of the increase in research and development expenditures while the Life Science segment showed modest growth.  Areas of development for the Life Science segment are proteomics, process chromatography and food safety and reagents across several core scientific methods.  Clinical Diagnostics segment development efforts were focused on assay development for the Bio-Plex 2200 ^TM platform and improvements to existing product offerings in blood virus, diabetes monitoring and clinical microbiology and offerings from its quality cont rol product line.

18

Corporate Results – Other Items

Interest expense for the nine months ended 2005 increased from the same period in the prior year by $9.4 million. This increase is the net effect of Bio-Rad increasing its average indebtedness from $236.5 million in the nine months ended 2004 to $435.9 million for the nine months ended 2005.  In December of 2004, we borrowed an additional $200 million of subordinated debt at 6.125%.

Exchange gains and losses consist of foreign currency transaction gains and losses on intercompany net receivables and payables and the change in fair value of our forward foreign exchange contracts used to manage our foreign exchange risk.  The exchange gains reported in the 2005 period reflect the strengthening of the Brazilian Real versus the US dollar and the Euro.  In late 2004, we stopped hedging the Real because of the expense, moving to an unhedged position for these intercompany receivables and payables.  Losses in 2004 included the cost of hedging the Brazilian Real.

Other income and expense for the nine months ended 2005 includes investment and interest income on our cash and cash equivalents, short-term and long-term investments, marketable securities and notes receivable.  During the nine months ended 2004, we recorded a $2.4 million write-down in an investee on whom we have no influence.

Bio-Rad’s effective tax rate on continuing operations was 24% and 30% for the nine months ended 2005 and 2004, respectively.  The reduction in tax rate resulted from an increase in the benefit for the foreign organizational restructuring, a benefit for reduction in the valuation allowance for foreign defined tax assets and other miscellaneous items.

Our effective tax rate may be impacted in the future, either favorably or unfavorably, by many factors including but not limited to statutory tax rates, changes in existing laws or regulations, tax audits and settlements, and generation of tax credits.

In May 2004, we sold our U.K. based confocal microscopy product line to Carl Zeiss Jena GmbH.  As required by SFAS 144, the sales and expenses related to this product line for current and prior periods have been reclassified to a separate line on the income statement titled “Discontinued Operations.”  The original gain on divestiture in 2004 was $3.4 million, net of tax.  Proceeds received were $19.8 million and costs included assets transferred less related liabilities, legal costs, a provision for leased facilities through August 2008 and minor severance and other costs.  During the first quarter of 2005, we recorded a gain of $4.0 million in discontinued operations as a result of the reduction of the provision for leased facilities.  Bio-Rad and the landlord reached an agreement whereby we will leaveleft the premises by the third quarter of 2005 and will havewere required to pay only a portion of the remaining lea selease costs and partial dilapidation charges.

Six Months Ended June 30, 2005 Compared to

Six Months Ended June 30, 2004

Corporate Results -- Sales, Margins and Expenses

Net sales (sales) in the first half of 2005 rose 12.8% to $590.5 million from $523.3 million in the first half of 2004.  The positive impact to sales from a weakening US dollar represented $18.5 million. For Bio-Rad in total, on a currency neutral basis, sales grew 9.3% compared to the prior period.  Before adjustment to a currency neutral basis, the Clinical Diagnostics segment sales grew by 8.4% to $307.2 million and the Life Science segment sales grew 17.7% to $277.2 million.  On a currency neutral basis, the Clinical Diagnostics segment’s sales increased 4.8% and the Life Science segment’s sales grew 14.3%.  The Clinical Diagnostic sales increase is principally due to its quality control, autoimmune testing and diabetes monitoring products.  Life Science segment sales growth is attributable to multiplex protein array technology, amplification reagents, and electrophoresis product lines.  Lif e Science segment sales declined for food science products as our BSE test faces significant competitive pricing pressure which has resulted in a lower average selling price.19

Consolidated gross margins were 55.4% for the first half of 2005 compared to 57.1% for the first half of 2004 and 56.0% for all of 2004.  Life Science segment gross margins excluding the BSE product line declined from the prior year.  This decline has been caused by a shift in sales mix to lower margin instruments with the acquisition of MJ Research and amortization of intangibles.  The gross margin for the BSE product line has declined, further affecting the Life Science segment due to lower overall average prices in a consolidating and competitive market.  Diagnostic margins have remained unchanged during the period.   With the continued global integration of MJ products into the Bio-Rad direct sales force, expiration of distributor agreements and reduction in overhead costs, Life Science segment margins should improve.

Selling, general and administrative expenses (SG&A) represented 34.5% of sales for the first half of 2005 compared to 33.9% of sales in the prior year period.  Both Life Science and Clinical Diagnostics segments have increased spending at a rate in excess of sales growth.  Expenses contributing to this overall increase include personnel costs, the amortization of acquired intangibles, financial compliance including external and internal audit fees, and consulting fees related to information technology infrastructure.

17

Product research and development expense increased 10.9% to $55.3 million in the first half of 2005 compared to the same period in 2004 excluding $0.9 million of expense for acquired in-process research and development in the first quarter of 2004 associated with our acquisition of Hematronix. Both Life Science and Clinical Diagnostics segments increased their research and development expenditures in absolute dollars.  Areas of development for the Life Science segment are proteomics, process chromatography and food safety and reagents across several core scientific methods.  Clinical Diagnostics segment development efforts were focused on completion and regulatory approval of the Bioplex^TM 2200 platform and diagnostic test panels for it and improvements to existing product offerings in blood virus, diabetes monitoring and clinical microbiology.

Corporate Results^ Other Items

Interest expense for the first half of 2005 increased from the same period in the prior year by $6.2 million. This increase is the net effect of Bio-Rad increasing its average indebtedness from $235.0 million in the first half of 2004 to $436 million for the first half of 2005.  In December of 2004, we borrowed an additional $200 million of subordinated debt at 6.125%.

Exchange gains and losses consist of foreign currency transaction gains and losses on intercompany net receivables and payables and the change in fair value of our forward foreign exchange contracts used to manage our foreign exchange risk.  The exchange gains reported in the 2005 period reflect the strengthening of the Brazilian Real versus the US dollar and the Euro.  In late 2004, we stopped hedging the Real because of the expense, moving to an unhedged position for these intercompany receivables and payables.  Losses in 2004 included the cost of hedging the Brazilian Real.

Other income and expense for the first half of 2005 includes investment and interest income on our cash and cash equivalents, short-term investments, marketable securities and notes receivable.  We also include in this category any gains or losses associated with the sale of any surplus manufacturing equipment or other productive assets.  During the first half of 2004, we recorded a $2.4 million write-down in an investee on whom we have no influence.

Bio-Rad’s effective tax rate on continuing operations was 25% and 29% for the first half of 2005 and 2004, respectively.  The reduction in tax rate resulted from foreign organizational efficiencies.

Financial Condition

As of JuneSeptember 30, 2005, we had available $252.1$244.0 million in cash and cash equivalents and $24.1$28.1 million under international lines of credit.  We also had $91.3$114.5 million of short-term investments.  Under the $150.0 million restated and amended Revolving Credit Facility we have $145.0$145.6 million available with $5.0$4.4 million reserved for standby letters of credit issued by our banks to guarantee our obligations to certain insurance companies.  Management believes that this availability, together with cash flow from operations, will be adequate to meet our current objectives for operations, research and development, capital additions for plant, equipment and systems and potential acquisitions.

18

Net cash provided by operations was $27.8$58.9 million and $47.5$72.1 million for the sixnine months ended JuneSeptember 30, 2005 and 2004, respectively.  This decline represents increased operating expenditures for SG&A and research and development including personnel costs, legal fees, auditing fees and other professional fees for information technology enhancements, advertisinginfrastructure, and promotion.third party commissions.  Additionally, we have increased our investment in inventory for new product introductions.introductions, and in anticipation of increased fourth quarter deliveries and customer acceptance where required.

At JuneSeptember 30, 2005, consolidated net accounts receivable were $243.4$244.5 million, a decrease of $17.9$16.8 million from December 31, 2004.  The decline in consolidated accounts receivable is attributable to lower sequential quarterly sales and a strengthening of the US dollar from December 31, 2004 to JuneSeptember 30, 2005.  This causes receivables from our customers denominated in their local currency to decline in terms of their US dollar value.

At JuneSeptember 30, 2005, consolidated net inventories increased $6.0$17.6 million from December 31, 2004.  We have increased inventories in connection with our protein and gene expression product lines in the Life Science segment.  Clinical Diagnostics segment increases are attributable to Bio-Plex 2200^TM equipment, a new diagnostic platform.platform and quality control product, which has scheduled fourth quarter deliveries in excess of its routine inventory build cycle.  The impact of a strengthened US dollar has caused an offsetting reduction in the value of inventory held in a foreign currency.

Net capital expenditures totaled $17.6$26.3 million for the sixnine months ended JuneSeptember 30, 2005 compared to $29.1$41.6 million for the same period of 2004.  Capital expenditures represent the addition and replacement of production machinery and research equipment, ongoing manufacturing and facility additions for compliance, information technology equipment and leasehold improvements. All periods include reagent rental equipment placed with Clinical Diagnostics segment customers who then contract to purchase our reagents for use on this equipment.

We continue to review possible acquisitions to expand both our Life Science and Clinical Diagnostics segments.  We routinely meet with the principals or brokers of the subject companies.  We are evaluating a number of acquisitions on a preliminary basis, but it is not certain that any of these transactions will advance beyond the preliminary stages to be completed.  On April 6,

20

At September 30, 2005, we submitted a proposal to the Board of Directors of BioSource International, Inc., a life sciences company, to acquire all of BioSource’s outstandingowned 665,639 shares for $8.50 per share in cash.  We currently own approximately 6.9% of the outstanding shares of BioSource.  On July 26, 2005, BioSource and Invitrogen announced in a press release that Invitrogen had agreed to buy BioSource for $12.50 per share in cash per share or $130 million.  AlthoughIn October 2005, Bio-Rad tendered its shares in BioSource and received cash of approximately $8.3 million.  Bio-Rad owned 12,164,237 shares of Instrumentation Laboratory, S.p.A. at September 30, 2005.  In October 2005, we have not made any further attemptsentered into an agreement to acquire BioSource, we are reviewingsell all our options.shares back to Instrumentation Laboratory S.p.A. and received cash of approximately $12.0 million.  A pre-tax gain on these transactions of approximately $11 million will be recorded in other income in the fourth quarter of 2005.

The Board of Directors has authorized the repurchase of up to $18.0 million of Bio-Rad's common stock over an indefinite period of time.  Through JuneSeptember 30, 2005, Bio-Rad has cumulatively repurchased 1,179,272 shares of Class A Common Stock and 60,000 shares of Class B Common Stock for a total of $14.7 million.  Our credit agreements restrict our ability to repurchase our stock. There were no share repurchases made during 2005 or 2004.  The repurchase was designed to both satisfy our obligations under the employee stock purchase and stock option plans and to improve shareholder value.

Item 3.

Quantitative and Qualitative Disclosures about Market Risk

During the sixnine months ended JuneSeptember 30, 2005, there have been no material changes from the disclosures about market risk provided in our Annual Report on Form 10-K for the year ended December 31, 2004.

19

Item 4.

Controls and Procedures

Bio-Rad maintains disclosure controls and procedures that are designed to ensure that information required to be disclosed in Bio-Rad’s Exchange Act reports is recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commission's rules and forms and that such information is accumulated and communicated to Bio-Rad’s management, including its Chief Executive Officer and Chief Financial Officer, as appropriate, to allow for timely decisions regarding required disclosure.  In designing and evaluating the disclosure controls and procedures, management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving the desired control objectives, and management is required to apply its judgment in evaluating the cost-benefit relationship of possible controls and procedures.  

As required by SEC Rule 13a-15(b), we carried out an evaluation, under the supervision and with the participation of our management, including the Chief Executive Officer and Chief Financial Officer, of the effectiveness of the design and operation of our disclosure controls and procedures as of the end of the quarter covered by this report.  Based on the foregoing,our Chief Executive Officer and Chief Financial Officer concluded that our disclosure controls and procedures were effective at the reasonable assurance level.

There has been no change in our internal controls over financial reporting during the most recent fiscal quarter that has materially affected, or is reasonably likely to materially affect, our internal controls over financial reporting.

21

PART II – OTHER INFORMATION

Item 1.

Legal Proceedings

See Note 17, “Legal Proceedings” in the Notes to Condensed Consolidated Financial Statements of Part 1, Item 1 of this Form 10-Q.

Item 4.6.

Submission of Matters to a Vote of Security Holders.Exhibits

At Bio-Rad's annual meeting of stockholders on April 26, 2005, the following individuals were reelected to the Board of Directors:(a)Exhibits

20

The following proposals were approved at our annual meeting:

The foregoing matters are described in detail on pages 5, 6, 19, 20, and 21 of Bio-Rad’s definitive Proxy Statement dated April 1, 2005, filed with the Securities and Exchange Commission and incorporated herein by reference.