Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15 (d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes  No 

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes  No 

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.:

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. 

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act.): Yes  No 

The number of shares outstanding of the registrant’s common stock on ~~July 29,~~October 28, 2022 was ~~55,491,199~~55,524,439.


	June 30,			December 31,			September 30,			December 31,
	2022			2021			2022			2021
ASSETS
Current assets:
Cash and cash equivalents	$	596,512		$	603,814		$	573,363		$	603,814
Accounts receivable, net of reserves of $1,279 and $1,417 at June 30, 2022 and December 31, 2021, respectively		121,050			117,420
Accounts receivable, net of reserves of $1,350 and $1,417 at September 30, 2022 and December 31, 2021, respectively								117,645			117,420
Inventories, net		239,117			184,494			242,695			184,494
Prepaid expenses and other current assets		19,316			25,949			19,530			25,949
Total current assets		975,995			931,677			953,233			931,677
Noncurrent assets:
Property, plant and equipment, net		168,370			124,964			174,255			124,964
Intangible assets, net		322,208			337,274			359,560			337,274
Goodwill		854,328			860,362			851,406			860,362
Deferred tax assets		1,907			1,903			1,756			1,903
Operating lease right of use assets		121,339			101,559			121,522			101,559
Other noncurrent assets		769			615			800			615
Total noncurrent assets		1,468,921			1,426,677			1,509,299			1,426,677
Total assets	$	2,444,916		$	2,358,354		$	2,462,532		$	2,358,354
LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
Accounts payable	$	40,379		$	36,203		$	25,251		$	36,203
Operating lease liability		11,692			8,303			13,156			8,303
Current contingent consideration		17,046			0			13,491			—
Accrued liabilities		70,693			75,498			74,633			75,498
Convertible Senior Notes, net		283,712			255,258			284,165			255,258
Total current liabilities		423,522			375,262			410,696			375,262
Noncurrent liabilities:
Deferred tax liabilities		23,651			33,480			23,413			33,480
Noncurrent operating lease liability		121,271			102,492			121,190			102,492
Noncurrent contingent consideration		67,897			94,238			69,143			94,238
Other noncurrent liabilities		3,211			2,815			2,981			2,815
Total noncurrent liabilities		216,030			233,025			216,727			233,025
Total liabilities		639,552			608,287			627,423			608,287
Commitments and contingencies (Note 9)
Stockholders' equity:
Preferred stock, $0.01 par value, 5,000,000 shares authorized, 0 shares issued or outstanding		0			0
Common stock, $0.01 par value; 80,000,000 shares authorized; 55,465,918 shares at June 30, 2022 and 55,321,457 shares at December 31, 2021 issued and outstanding		555			553
Preferred stock, $0.01 par value, 5,000,000 shares authorized, no shares issued or outstanding								—			—
Common stock, $0.01 par value; 80,000,000 shares authorized; 55,519,646 shares at September 30, 2022 and 55,321,457 shares at December 31, 2021 issued and outstanding								555			553
Additional paid-in capital		1,533,762			1,572,340			1,541,272			1,572,340
Accumulated other comprehensive loss		(37,091	)		(16,886	)		(55,261	)		(16,886	)
Accumulated earnings		308,138			194,060			348,543			194,060
Total stockholders’ equity		1,805,364			1,750,067			1,835,109			1,750,067
Total liabilities and stockholders’ equity	$	2,444,916		$	2,358,354		$	2,462,532		$	2,358,354

The accompanying notes are an integral part of these consolidated financial statements.


	Three Months Ended June 30,						Six Months Ended June 30,						Three Months Ended September 30,						Nine Months Ended September 30,
	2022			2021			2022			2021			2022			2021			2022			2021
Revenue:
Products	$	207,597		$	162,920		$	413,960		$	305,657		$	200,708		$	178,177		$	614,668		$	483,834
Royalty and other revenue		36			40			73			140			33			39			106			179
Total revenue		207,633			162,960			414,033			305,797			200,741			178,216			614,774			484,013
Costs and operating expenses:
Cost of product revenue		86,260			61,990			168,616			121,737			86,514			75,495			255,130			197,232
Research and development		10,440			8,389			22,595			16,001			10,228			9,154			32,823			25,155
Selling, general and administrative		54,649			44,341			108,949			83,436			53,643			48,373			162,592			131,809
Contingent consideration		(6,884	)		0			(9,295	)		0			(2,309	)		—			(11,604	)		—
Total costs and operating expenses		144,465			114,720			290,865			221,174			148,076			133,022			438,941			354,196
Income from operations		63,168			48,240			123,168			84,623			52,665			45,194			175,833			129,817
Other income (expenses):
Investment income		708			41			785			93			2,177			44			2,962			137
Interest expense		(271	)		(2,787	)		(563	)		(5,541	)		(329	)		(2,859	)		(892	)		(8,400	)
Amortization of debt issuance costs		(453	)		(357	)		(905	)		(709	)		(455	)		(361	)		(1,360	)		(1,070	)
Other expenses		(3,396	)		(779	)		(3,798	)		(1,003	)		(6,591	)		(786	)		(10,389	)		(1,789	)
Other expenses, net		(3,412	)		(3,882	)		(4,481	)		(7,160	)		(5,198	)		(3,962	)		(9,679	)		(11,122	)
Income before income taxes		59,756			44,358			118,687			77,463			47,467			41,232			166,154			118,695
Income tax provision		9,895			8,125			21,862			11,780			7,062			7,734			28,924			19,514
Net income	$	49,861		$	36,233		$	96,825		$	65,683		$	40,405		$	33,498		$	137,230		$	99,181
Earnings per share:
Basic	$	0.90		$	0.66		$	1.75		$	1.20		$	0.73		$	0.61		$	2.48		$	1.81
Diluted (Note 12)	$	0.88		$	0.64		$	1.68		$	1.16		$	0.71		$	0.58		$	2.39		$	1.74
Weighted average common shares outstanding:
Basic		55,444			54,931			55,399			54,868			55,498			55,015			55,432			54,918
Diluted (Note 12)		56,721			56,786			57,842			56,824			57,304			57,368			57,598			57,072

Net income	$	49,861		$	36,233		$	96,825		$	65,683		$	40,405		$	33,498		$	137,230		$	99,181
Other comprehensive income (loss):
Foreign currency translation adjustment		(15,517	)		3,125			(20,205	)		(6,454	)		(18,170	)		(5,550	)		(38,375	)		(12,004	)
Comprehensive income	$	34,344		$	39,358		$	76,620		$	59,229		$	22,235		$	27,948		$	98,855		$	87,177

The accompanying notes are an integral part of these consolidated financial statements.


	Six Months Ended June 30, 2022																	Nine Months Ended September 30, 2022
	Common Stock																	Common Stock
	Number of Shares			Par Value			Additional Paid-In Capital			Accumulated Other Comprehensive Loss			Retained Earnings		Total Stockholders' Equity			Number of Shares			Par Value			Additional Paid-In Capital			Accumulated Other Comprehensive Loss			Retained Earnings		Total Stockholders' Equity
Balance at December 31, 2021		55,321,457		$	553		$	1,572,340		$	(16,886	)	$	194,060	$	1,750,067			55,321,457		$	553		$	1,572,340		$	(16,886	)	$	194,060	$	1,750,067
Impact of the adoption of ASU 2020-06		—			—			(39,070	)		—			17,253		(21,817	)		—			—			(39,070	)		—			17,253		(21,817	)
Net income		—			—			—			—			96,825		96,825			—			—			—			—			137,230		137,230
Issuance of common stock for debt conversion		12			0			(5	)		—			—		(5	)		15			0			(5	)		—			—		(5	)
Exercise of stock options and vesting of stock units		222,727			3			460			—			—		463			281,839			3			2,781			—			—		2,784
Tax withholding on vesting of restricted stock units		(78,278	)		(1	)		(14,758	)		—			—		(14,759	)		(83,665	)		(1	)		(15,828	)		—			—		(15,829	)
Stock-based compensation expense		—			—			14,900			—			—		14,900			—			—			21,054			—			—		21,054
Translation adjustment		—			—			—			(20,205	)		—		(20,205	)		—			—			—			(38,375	)		—		(38,375	)
Other		—			—			(105	)		—			—		(105	)
Balance at June 30, 2022		55,465,918		$	555		$	1,533,762		$	(37,091	)	$	308,138	$	1,805,364
Balance at September 30, 2022																			55,519,646		$	555		$	1,541,272		$	(55,261	)	$	348,543	$	1,835,109


	Three Months Ended June 30, 2022																	Three Months Ended September 30, 2022
	Common Stock																	Common Stock
	Number of Shares			Par Value			Additional Paid-In Capital			Accumulated Other Comprehensive Loss			Retained Earnings		Total Stockholders' Equity			Number of Shares			Par Value			Additional Paid-In Capital			Accumulated Other Comprehensive Loss			Retained Earnings		Total Stockholders' Equity
Balance at March 31, 2022		55,429,046		$	554		$	1,529,144		$	(21,574	)	$	258,277	$	1,766,401
Balance at June 30, 2022																			55,465,918		$	555		$	1,533,762		$	(37,091	)	$	308,138	$	1,805,364
Net income		—			—			—			—			49,861		49,861			—			—			—			—			40,405		40,405
Issuance of common stock for debt conversion		4			(0	)		(3	)							(3	)		3			(0	)		(0	)		—			—		(0	)
Exercise of stock options and vesting of stock units		51,737			1			166			—			—		166			59,112			0			2,321			—			—		2,321
Tax withholding on vesting of restricted stock units		(14,869	)		(0	)		(2,448	)							(2,448	)		(5,387	)		(0	)		(1,070	)		—			—		(1,070	)
Stock-based compensation expense		—			—			6,985			—			—		6,985			—			—			6,154			—			—		6,154
Translation adjustment		—			—			—			(15,517	)		—		(15,517	)		—			—			—			(18,170	)		—		(18,170	)
Other		—			—			(82	)		—			—		(82	)		—			—			105			—			—		105
Balance at June 30, 2022		55,465,918		$	555		$	1,533,762		$	(37,091	)	$	308,138	$	1,805,364
Balance at September 30, 2022																			55,519,646		$	555		$	1,541,272		$	(55,261	)	$	348,543	$	1,835,109


	Six Months Ended June 30, 2021														Nine Months Ended September 30, 2021
	Common Stock														Common Stock
	Number of Shares		Par Value		Additional Paid-In Capital		Accumulated Other Comprehensive Income (Loss)			Retained Earnings		Total Stockholders' Equity			Number of Shares			Par Value			Additional Paid-In Capital			Accumulated Other Comprehensive Income (Loss)			Retained Earnings		Total Stockholders' Equity
Balance at December 31, 2020		54,760,837	$	548	$	1,460,748	$	2,085		$	65,769	$	1,529,150			54,760,837			548		$	1,460,748		$	2,085		$	65,769	$	1,529,150
Net income		—		—		—		—			65,683		65,683			—			—			—			—			99,181		99,181
Issuance of common stock for debt conversion		3		0		1		—			—		1			7			0			2			—			—		2
Exercise of stock options and vesting of stock units		208,641		2		858		—			—		860			257,387			2			1,989			—			—		1,991
Issuance of common stock pursuant to the acquisition of Avitide Inc.																271,096			3			77,573			—			—		77,576
Tax withholding on vesting of restricted stock units																(5,339	)		(0	)		(1,252	)		—			—		(1,252	)
Stock-based compensation expense		—		—		13,684		—			—		13,684			—			—			20,476			—			—		20,476
True-up of costs related to the December 2020 issuance of common stock		—		—		145		—			—		145			—			—			145			—			—		145
Translation adjustment		—		—		—		(6,454	)		—		(6,454	)		—			—			—			(12,004	)		—		(12,004	)
Balance at June 30, 2021		54,969,481	$	550	$	1,475,436	$	(4,369	)	$	131,452	$	1,603,069
Balance at September 30, 2021																55,283,988		$	553		$	1,559,681		$	(9,919	)	$	164,950	$	1,715,265

The accompanying notes are an integral part of these consolidated financial statements.


	Six Months Ended June 30,						Nine Months Ended September 30,
	2022			2021			2022			2021
Cash flows from operating activities:
Net income	$	96,825		$	65,683		$	137,230		$	99,181
Adjustments to reconcile net income to net cash provided by operating activities:
Inventory step-up amortization		0			1,598			—			1,868
Depreciation and amortization		23,933			17,420			36,605			27,430
Amortization of debt discount and issuance costs		905			5,690			1,360			8,592
Stock-based compensation expense		14,900			13,684			21,054			20,476
Deferred income taxes, net		738			5,266			1,722			6,071
Contingent consideration		(9,295	)		0			(11,604	)		—
Other		276			103			210			677
Changes in operating assets and liabilities, excluding impact of acquisitions:
Accounts receivable		(8,433	)		(31,940	)		(8,609	)		(51,927	)
Inventories		(58,106	)		(42,773	)		(64,308	)		(61,598	)
Prepaid expenses and other assets		2,402			(563	)		168			471
Operating lease right of use assets		(21,457	)		3,582			(22,033	)		(3,018	)
Other assets		(406	)		1,748			(298	)		728
Accounts payable		6,322			8,317			(10,124	)		8,968
Accrued expenses		(4,014	)		4,467			3,043			10,051
Operating lease liabilities		23,852			(3,713	)		26,157			3,042
Long-term liabilities		392			(1,655	)		(372	)		(1,616	)
Total cash provided by operating activities		68,834			46,913			110,201			69,396
Cash flows from investing activities:
Acquisitions, net of cash acquired		0			71			—			(120,979	)
Additions to capitalized software costs		(1,875	)		(2,191	)		(2,568	)		(2,945	)
Purchases of property, plant and equipment		(52,576	)		(24,078	)		(64,390	)		(34,969	)
Purchase of intellectual property								(45,000	)		—
Other investing activities		17			0			30			—
Total cash used in investing activities		(54,434	)		(26,198	)		(111,928	)		(158,893	)
Cash flows from financing activities:
Proceeds from exercise of stock options		463			860			2,784			1,991
Payment of tax withholding obligation on vesting of restricted stock		(14,759	)		0			(15,829	)		(1,252	)
Repayment of Convertible Senior Notes		(18	)		(8	)		(18	)		(9	)
Total cash (used in) provided by financing activities		(14,314	)		852			(13,063	)		730
Effect of exchange rate changes on cash, cash equivalents and restricted cash		(7,388	)		(4,532	)		(15,661	)		(7,427	)
Net (decrease) increase in cash, cash equivalents and restricted cash		(7,302	)		17,035
Net decrease in cash, cash equivalents and restricted cash								(30,451	)		(96,194	)
Cash, cash equivalents and restricted cash, beginning of period		603,814			717,292			603,814			717,292
Cash and cash equivalents, end of period	$	596,512		$	734,327		$	573,363		$	621,098
Supplemental disclosure of non-cash investing and financing activities:
Assets acquired under operating leases	$	21,739		$	28,605		$	25,705		$	32,518
Fair value of 271,096 shares of common stock issued for the acquisition of Avitide, Inc.							$	—		$	77,576
Fair value of earnouts related to acquisition of Avitide, Inc.							$	—		$	79,962

The accompanying notes are an integral part of these consolidated financial statements.

Fair Value Measurements

The Company uses various valuation approaches in determining the fair value of its assets and liabilities. The Company employs a hierarchy for inputs used in measuring fair value that maximizes the use of observable inputs and minimizes the use of unobservable inputs by requiring that observable inputs be used when available. Observable inputs are inputs that market participants would use in pricing the asset or liability based on market data obtained from sources independent of the Company. Unobservable inputs are inputs that reflect the Company’s assumptions about the inputs that market participants would use in pricing the asset or liability and are developed based on the best information available in the circumstances. The fair value hierarchy is broken down into three levels based on the source of inputs as follows:


Level 1 –	Valuations based on unadjusted quoted prices in active markets for identical assets or liabilities that the Company has the ability to access.

Level 2 –	Valuations based on quoted prices for similar assets or liabilities in active markets, quoted prices for identical or similar assets or liabilities in markets that are not active and models for which all significant inputs are observable, either directly or indirectly.

Level 3 –	Valuations based on inputs that are unobservable and significant to the overall fair value measurement.

The availability of observable inputs can vary among the various types of financial assets and liabilities. To the extent that the valuation is based on models or inputs that are less observable or unobservable in the market, the determination of fair value requires more judgment. In certain cases, the inputs used to measure fair value may fall into different levels of the fair value hierarchy. In such cases, for financial statement disclosure purposes, the level in the fair value hierarchy within which the fair value measurement is categorized is based on the lowest level input that is significant to the overall fair value measurement.

Fair Value Measured on a Recurring Basis

Financial assets and financial liabilities measured at fair value on a recurring basis consist of the following as of ~~June~~September 30, 2022 and December 31, 2021 (amounts in thousands):


	As of June 30, 2022								As of September 30, 2022
	Level 1		Level 2		Level 3		Total		Level 1		Level 2		Level 3		Total
Assets:
Money market accounts	$	389,374	$	—	$	—	$	389,374	$	408,923	$	—	$	—	$	408,923

Liabilities:
Short-term contingent consideration	$	—	$	—	$	17,046	$	17,046	$	—	$	—	$	13,491	$	13,491
Long-term contingent consideration	$	—	$	—	$	67,897	$	67,897	$	—	$	—	$	69,143	$	69,143

	As of December 31, 2021								As of December 31, 2021
	Level 1		Level 2		Level 3		Total		Level 1		Level 2		Level 3		Total
Assets:
Money market accounts	$	460,936	$	—	$	—	$	460,936	$	460,936	$	—	$	—	$	460,936

Liabilities:
Long-term contingent consideration	$	—	$	—	$	94,238	$	94,238	$	—	$	—	$	94,238	$	94,238

Cash and cash equivalents

As of ~~June~~September 30, 2022 and December 31, 2021, cash and cash equivalents on the Company's consolidated balance sheets included $~~389.4~~408.9 million and $460.9 million, respectively, in money market accounts. These funds are valued on a recurring basis using Level 1 inputs.

Contingent Consideration – Earnout

On September 20, 2021, the Company completed the acquisition of Avitide, Inc. ("Avitide") (the "Avitide Acquisition"), a privately-held affinity ligand discovery and development company headquartered in Lebanon, New Hampshire. The transaction consisted of upfront payments of $150.0 million, comprised of cash and the Company's common stock, and up to an additional $125.0 million (undiscounted) in contingent consideration for performance-based earnout payments made equally in cash and the Company's common stock over a three-year performance period beginning January 1, 2022 and ending December 31, 2024. See Note 3, "Acquisitions" below for additional information.

During 2022, ~~there was~~an increase in risk-free interest rates that are used to calculate the discount rate and a minor shift in revenue and volume projections, due to the expected timing of achievement over the three-year performance period ~~and an increase in risk-free interest rates that are used to calculate the discount rate, that~~ resulted in a material change in amounts reported as of ~~June~~September 30, 2022. A reconciliation of the change in the fair value of contingent consideration - earnout is included in the following table (amounts in thousands):

Balance as of December 31, 2021

$
94,238

Contingent consideration earnouts

(9,295
)
Balance as of June 30, 2022

$
84,943


Balance at December 31, 2021	$	94,238
Decrease in fair value of contingent consideration earnouts		(11,604	)
Balance at September 30, 2022	$	82,634

910

The recurring Level 3 fair value measurement of our contingent consideration earnout that we expect to be required to settle include the following significant unobservable inputs (amounts in thousands, except percent data):


Contingent Consideration Earnout	Fair Value as of June 30, 2022		Valuation Technique	Unobservable Input	Range	Weighted Average(1)	Fair Value as of September 30, 2022		Valuation Technique	Unobservable Input	Range	Weighted Average(1)
				Probability of						Probability of
Commercialization-based			Monte Carlo	Success	100%	100%			Monte Carlo	Success	100%	100%
payments	$	28,390	Simulation	Earnout Discount Rate	4.5%-5.8%	5.1%	$	28,441	Simulation	Earnout Discount Rate	5.4%-6.7%	6.0%

				Volatility	23.7%	23.7%				Volatility	23.7%	23.7%
Revenue and Volume-			Monte Carlo	Revenue & Volume					Monte Carlo	Revenue & Volume
based payments	$	56,553	Simulation	Discount Rate	7.4%	7.4%	$	54,193	Simulation	Discount Rate	7.7%	7.7%
				Earnout Discount Rate	4.5%-5.8%	5.1%				Earnout Discount Rate	5.4%-6.7%	6.0%

(1)

Unobservable inputs were weighted by the relative fair value of the contingent consideration liability.

The Company estimates the fair value of the contingent consideration earnouts at each subsequent reporting period using a Monte Carlo simulation. Changes in the projected performance of the acquired business could result in a higher or lower contingent consideration obligation in the future.

Fair Value Measured on a Nonrecurring Basis

During the three and ~~six~~nine months ended ~~June~~September 30, 2022, there were no re-measurements to the fair value of financial assets and liabilities that are measured at fair value on a nonrecurring basis.

Convertible Senior Notes

In July 2019, the Company issued $287.5 million aggregate principal amount of the 2019 Notes. Interest is payable semi-annually in arrears on January 15 and July 15 of each year. The 2019 Notes will mature on July 15, 2024, unless earlier converted or repurchased in accordance with their terms. At ~~June~~September 30, 2022 and December 31, 2021, the carrying value of the 2019 Notes was $~~283.7~~284.2 million and $255.3 million, respectively, net of unamortized discount and issuance costs, and the fair value of the 2019 Notes was $~~432.3~~494.6 million and $678.5 million, respectively. The fair value of the 2019 Notes is a Level 1 valuation and was determined based on the most recent trade activity of the 2019 Notes as of ~~June~~September 30, 2022. The 2019 Notes are discussed in more detail in Note 7, “Convertible Senior Notes” to this report.

Acquisitions

2021 Acquisitions

Bio-Flex Solutions L.L.C. and Newton T&M Corp.

On November 29, 2021, the Company entered into an Equity Purchase Agreement with BioFlex, NTM and each of Ralph Meola and Jason Nisler (the "Equity Purchase Agreement"), to acquire 100% of the outstanding securities of BioFlex and NTM (collectively, the “NTM Acquisition”). The transaction closed on December 16, 2021.

NTM, which is headquartered in Newton, New Jersey, is the parent company of BioFlex and focuses on manufacturing of products, while BioFlex, also headquartered in Newton, New Jersey, commercializes branded products to biotech customers. The NTM Acquisition complements and expands the Company's filtration offering paths as the industry migrates to single-use flow paths solutions for monoclonal antibody, vaccine and cell and gene therapy ("C&GT") applications, with a focus on single-use fluid management components, including single-use clamps, adapters, end caps and hose assemblies. The NTM Acquisition streamlines and increases control over many components in the Company's single-use supply chain which ultimately should drive reduced lead-times for Repligen customers in the coming years.

Consideration Transferred

The NTM Acquisition was accounted for as a purchase of businesses under ASC 805, “Business Combinations,” and the Company engaged a third-party valuation firm to assist with the valuation of the business acquired. Under the terms of the Equity Purchase Agreement, all outstanding shares of capital stock of BioFlex were acquired for consideration with a value totaling $31.6 million, which includes $3.0 million deposited into an escrow against which the Company may make claims for indemnification.

Under the acquisition method of accounting, the assets acquired and liabilities assumed of BioFlex were recorded as of the acquisition date, at their respective fair values, and consolidated with those of the Company. The fair value of the net assets acquired is estimated to be $4.6 million, the fair value of the intangible assets acquired is estimated to be $17.2 million and the residual goodwill is estimated to be $9.8 million. The estimated consideration and preliminary purchase price information has been prepared using a preliminary valuation. Acquisition-related costs are not included as a component of consideration transferred but are expensed in the periods in which costs are incurred. The Company has incurred $~~1.9~~2.5 million of transaction and integration costs associated with the NTM Acquisition from the date of acquisition to ~~June~~September 30, 2022, with $~~0.7~~0.6 million and $~~1.6~~2.2 million of transaction and integration costs incurred during the three and ~~six~~nine months ended ~~June~~September 30, 2022, respectively. The transaction costs are included in operating expenses in the consolidated statements of comprehensive income for the ~~periods~~three and nine months ended ~~June~~September 30, 2022.

The preparation of the valuation required the use of significant assumptions and estimates. Critical estimates included, but were not limited to, future expected cash flows, including projected revenues and expenses and the applicable discount rates. These estimates were based on assumptions that the Company believes to be reasonable. However, actual results may differ from these estimates.

Fair Value of Net Assets Acquired

The preliminary allocation of purchase price is based on the fair value of assets acquired and liabilities assumed as of the acquisition date, based on the preliminary valuation. As of ~~June~~September 30, 2022, the purchase accounting for this acquisition had not yet been finalized. As additional information becomes available, the Company may further revise its preliminary purchase price allocation during the remainder of the measurement period. Any such revisions or changes may have a material impact on our accounting treatment of the NTM Acquisition. The final allocation may include changes to deferred tax assets and other assets and liabilities.

The components and estimated allocation of the purchase price consist of the following (amounts in thousands):


Cash and cash equivalents	$	2,870
Accounts receivable		1,408
Inventory		741
Prepaid expenses and other current assets		126
Property and equipment		34
Operating lease right of use asset		1,034
Customer relationships		13,240
Developed technology		3,540
Trademark and tradename		310
Non-competition agreements		60
Goodwill		9,804
Long term deferred tax asset		111
Accounts payable		(224	)
Accrued liabilities		(450	)
Operating lease liability		(1,030	)
Operating lease liability, long-term		(3	)
Fair value of net assets acquired	$	31,571

During the ~~first half of~~nine months ended September 30, 2022, the Company recorded net working capital adjustments of approximately $0.4 million related to pre-acquisition liabilities, which are included in goodwill and accrued liabilities in the table above.

Acquired Goodwill

The goodwill of $9.8 million represents future economic benefits expected to arise from anticipated synergies from the integration of BioFlex and NTM into the Company. These synergies include ~~certain cost savings,~~ operating efficiencies and ~~other~~ strategic benefits projected to be achieved as a result of the NTM Acquisition. Substantially all of the goodwill recorded is expected to be deductible for income tax purposes.

Intangible Assets

The following table sets forth the components of the identified intangible assets associated with the NTM Acquisition and their estimated useful lives:


	~~Useful life~~	~~Fair Value~~
		~~(Amounts in thousands)~~

~~Customer relationships~~	~~10 years~~	$	~~13,240~~
~~Developed technology~~	~~11 years~~		~~3,540~~
~~Trademark and tradename~~	~~15 years~~		~~310~~
~~Non-competition agreements~~	~~3 years~~		60
		$	~~17,150~~


	Useful life	Fair Value
		(Amounts in thousands)

Customer relationships	10 years	$	13,240
Developed technology	11 years		3,540
Trademark and tradename	15 years		310
Non-competition agreements	3 years		60
		$	17,150

Avitide, Inc.

On September 16, 2021, the Company entered into an Agreement and Plan of Merger and Reorganization (“Avitide Merger Agreement”) with Avalon Merger Sub, Inc., a Delaware corporation and a wholly owned direct subsidiary of the Company, Avalon Merger Sub LLC, a Delaware limited liability company and a wholly owned direct subsidiary of the Company, Avitide, a Delaware corporation, and Shareholder Representative Services LLC, a Colorado limited liability company, solely in its capacity as the representative, agent and attorney-in-fact of Avitide's securityholders to purchase Avitide. The transaction closed on September 20, 2021 on the terms set forth in the Avitide Merger Agreement.

Avitide, which is headquartered in Lebanon, New Hampshire, offers diverse libraries and leading technology in affinity ligand discovery and development resulting in best-in-class ligand discovery and development lead-times. The acquisition gives the Company a new platform for affinity resin development, including C&GT, and advances and expands the Company’s proteins and chromatography franchise to address the unique purification needs of gene therapies and other emerging modalities.

Consideration Transferred

The Avitide Acquisition was accounted for as a purchase of a business under ASC 805, “Business Combinations,” and the Company engaged a third-party valuation firm to assist with the valuation of the business acquired. Under the terms of the Avitide Merger Agreement, all outstanding shares of capital stock of Avitide were cancelled and converted into the right to receive merger consideration with a value totaling up to $275.0 million, which consisted of upfront payments in aggregate of $150.0 million ($149.4 million, net of cash acquired) and up to an additional $125.0 million (undiscounted) in contingent consideration earnout payments if certain performance targets are achieved. Total consideration paid also included $0.8 million deposited into an escrow account against which the Company may make claims for indemnification. The Avitide Acquisition was funded through payment of $75.0 million in cash, the issuance of 271,096 unregistered shares of the Company’s common stock totaling $83.0 million and contingent consideration with a fair value of approximately $88.4 million.

Under the acquisition method of accounting, the assets acquired and liabilities assumed of Avitide were recorded as of the acquisition date, at their respective fair values, and consolidated with those of the Company. The fair value of the net assets acquired is ~~estimated to be~~ $2.1 million, the fair value of the intangible assets acquired is ~~estimated to be~~ $46.7 million and the residual goodwill is ~~estimated to be~~ $197.5 million. The estimated consideration and preliminary purchase price information has been prepared using a preliminary valuation. Acquisition-related costs are not included as a component of consideration transferred but are expensed in the periods in which costs are incurred. The Company has incurred $~~3.9~~4.7 million of transaction and integration costs associated with the Avitide Acquisition from the date of acquisition to ~~June~~September 30, 2022, with $~~0.7~~0.8 million and $~~1.3~~2.1 million of transaction and integration costs incurred during the three and ~~six~~nine months ended ~~June~~September 30, 2022, ~~respectively.~~respectively and $0.6 million of transaction and integration costs incurred in each of the three and nine months ended September 30, 2021. The transaction costs are included in operating expenses in the consolidated statements of comprehensive income for the ~~periods~~three and nine months ended ~~June~~September 30, ~~2022.~~2022 and 2021. During 2022, due to the change in market inputs used to prepare the valuation of the contingent

consideration obligation, the Company also recorded contingent consideration adjustments of ($~~6.9~~2.3) million and ($~~9.3~~11.6) million to the Company's consolidated statements of comprehensive income for the three and ~~six~~nine months ended ~~June~~September 30, 2022, respectively. See Note 2, "Fair Value Measurements" for more information.

Total consideration transferred is as follows (amounts in thousands):


Cash consideration	$	74,962
Equity consideration		82,968
Contingent consideration - earnout		88,373
Fair value of net assets acquired	$	246,303

Fair Value of Net Assets Acquired

The ~~preliminary~~ allocation of purchase price is based on the fair value of assets acquired and liabilities assumed as of the acquisition date, based on the ~~preliminary valuation. As~~final valuation of ~~June 30, 2022,~~Avitide. The Company has made appropriate adjustments to the ~~purchase accounting for this acquisition had not yet been finalized. As additional information becomes available, the Company may further revise its preliminary~~ purchase price allocation during the ~~remainder of the~~ measurement period, ~~(which will not exceed 12 months from~~which ended on September 20, 2021). Any such revisions or changes may have a material impact on our accounting treatment of the Avitide Acquisition. The final allocation may include changes to long-term deferred liabilities and goodwill. Upon conclusion of the measurement period or final determination of the values of assets acquired or liabilities assumed, whichever comes first, any subsequent adjustments will be recorded to our consolidated statement of comprehensive income.2022.

The components and ~~estimated~~final allocation of the purchase price consist of the following (amounts in thousands):


Cash and cash equivalents	$	572		$	572
Accounts receivable		228			228
Inventory		332			332
Prepaid expenses and other current assets		114			114
Property and equipment		1,862			1,862
Operating lease right of use asset		3,648			3,648
Customer relationships		24,580			24,580
Developed technology		20,650			20,650
Trademark and tradename		1,210			1,210
Non-competition agreements		210			210
Goodwill		197,461			197,476
Long term deferred tax asset		1,540			1,525
Accounts payable		(215	)		(215	)
Accrued liabilities		(2,183	)		(2,183	)
Operating lease liability		(698	)		(698	)
Operating lease liability, long-term		(2,950	)		(2,950	)
Other liabilities		(58	)		(58	)
Fair value of net assets acquired	$	246,303		$	246,303

Acquired Goodwill

The goodwill of $197.5 million represents future economic benefits expected to arise from anticipated synergies from the integration of Avitide. These synergies include ~~certain cost savings,~~ operating efficiencies and ~~other~~ strategic benefits projected to be achieved as a result of the Avitide Acquisition. Substantially all of the goodwill recorded is expected to be nondeductible for income tax purposes. ~~In June~~During the nine months ended September 30, 2022, the Company recorded ~~an adjustment~~adjustments to goodwill of $1.8 million related to a change in estimated tax benefits associated with the net operating loss carryforward filed on the Avitide pre-acquisition tax return. The offset to these adjustments are included in long term deferred tax asset in the table above.

Intangible Assets

The following table sets forth the components of the identified intangible assets associated with the Avitide Acquisition and their estimated useful lives:


	Useful life	Fair Value
		(Amounts in thousands)

Customer relationships	13 years	$	24,580
Developed technology	15 years		20,650
Trademark and tradename	18 years		1,210
Non-competition agreements	3 years		210
		$	46,650

Polymem S.A.

On June 22, 2021, the Company entered into a Stock Purchase Agreement with Polymem, a company organized under the laws of France, and Jean-Michel Espenan and Franc Saux, acting together jointly and severally as the representatives of the sellers pursuant to which the Company acquired all of the outstanding common stock of Polymem for $47.0 million. The transaction closed on July 1, 2021 (the “Polymem Acquisition”).

Polymem, which is headquartered in, Toulouse, France, is a manufacturer of hollow fiber membranes, membrane modules and systems for industrial and bioprocessing applications. Polymem products will complement and expand the Company’s portfolio of hollow fiber systems and consumables. The acquisition substantially increases Repligen’s membrane and module manufacturing capacity and establishes a world-class center of excellence in Europe to address the accelerating global demand for these innovative products.

Consideration Transferred

The Polymem Acquisition was accounted for as a purchase of a business under ASC 805, “Business Combinations,” and the Company engaged a third-party valuation firm to assist with the valuation of the business acquired. Payment for the transaction was denominated in Euros but is reflected here in U.S. dollars for presentation purposes based on an exchange rate of 0.8437 as of July 1, 2021, the date of acquisition. Total consideration paid was approximately $47.0 million, which included approximately $4.3 million deposited into an escrow account against which the Company may make claims for indemnification.

Under the acquisition method of accounting, the assets acquired and liabilities assumed of Polymem were recorded as of the acquisition date, at their respective fair values, and consolidated with those of the Company. The fair value of the net assets acquired is approximately $2.2 million, the fair value of the intangible assets acquired is approximately $9.1 million and the residual goodwill is approximately $35.7 million. Acquisition-related costs are not included as a component of consideration transferred but are expensed in the periods in which costs are incurred. The Company has incurred $~~6.3~~7.1 million of transaction and integration costs associated with the Polymem Acquisition from the date of acquisition to ~~June~~September 30, 2022, with $~~1.6~~0.8 million and $~~3.2~~4.0 million of transaction and integration costs incurred during the three and ~~six~~nine months ended ~~June~~September 30, 2022, ~~respectively.~~respectively and $1.9 million of transaction and integration costs incurred during the three and nine months ended September 30, 2021. The transaction costs are included in operating expenses in the consolidated statements of comprehensive income for the periods ended ~~June~~three and nine months ended September 30, ~~2022.~~2022 and 2021.

Fair Value of Net Assets Acquired

The allocation of purchase price is based on the fair value of assets acquired and liabilities assumed as of the acquisition date, based on the final valuation of Polymem. The Company has made appropriate adjustments to the purchase price allocation during the measurement period, which ended on July 1, 2022.

The components and final allocation of the purchase price consist of the following (amounts in thousands):


Cash and cash equivalents	$	353
Net working capital (excluding cash and inventory step-up)		414
Inventory step-up		543
Operating lease right of use assets		1,424
Property and equipment		3,145
Other assets		41
Developed technology		8,274
Trademark and tradenames		510
Non-compete agreements		312
Goodwill		35,680
Operating lease liability		(1,253	)
Long term deferred tax liability		(2,327	)
Other long-term liabilities		(143	)
Fair value of net assets acquired	$	46,973

Acquired Goodwill

The goodwill of approximately $35.7 million represents future economic benefits expected to arise from anticipated synergies from the integration of Polymem. These synergies include ~~certain cost savings,~~ operating efficiencies and ~~other~~ strategic benefits projected to be achieved as a result of the Polymem Acquisition. Substantially all of the goodwill recorded is expected to be nondeductible for income tax purposes.

Intangible Assets

The following table sets forth the components of the identified intangible assets associated with the Polymem Acquisition and their estimated useful lives:


	Useful life	Fair Value
		(Amounts in thousands)
Developed technology	13 years	$	8,274
Trademark and tradename	14 years		510
Non-competition agreements	5 years		312
		$	9,096

Revenue Recognition

The Company generates revenue from the sale of bioprocessing products, equipment devices and related consumables used with these equipment devices to customers in the life science and biopharmaceutical industries. Under ASC 606, “Revenue from Contracts with Customers,” revenue is recognized when, or as, obligations under the terms of a contract are satisfied, which occurs when control of the promised products or services is transferred to customers.

Disaggregation of Revenue

Revenues for the three and ~~six~~nine months ended ~~June~~September 30, 2022 and 2021 were as follows:


	Three Months Ended June 30,				Six Months Ended June 30,				Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021		2022		2021		2022		2021
	(Amounts in thousands)								(Amounts in thousands)
Product revenue	$	207,597	$	162,920	$	413,960	$	305,657	$	200,708	$	178,177	$	614,668	$	483,834
Royalty and other income		36		40		73		140		33		39		106		179
Total revenue	$	207,633	$	162,960	$	414,033	$	305,797	$	200,741	$	178,216	$	614,774	$	484,013

When disaggregating revenue, the Company considered all of the economic factors that may affect its revenues. Because substantially all of its revenues are from bioprocessing customers, there are no differences in the nature, timing and uncertainty of the Company’s revenues and cash flows from any of its product lines. However, given that the Company’s revenues are generated in different geographic regions, regulatory, economic and geopolitical factors within those regions could impact the nature, timing and uncertainty of the Company’s revenues and cash flows. In addition, a significant portion of the Company’s revenue is generated from a small number of customers; therefore, economic factors specific to these customers could impact the nature, timing and uncertainty of the Company’s revenues and cash flows.

Disaggregated revenue from contracts with customers by geographic region and revenue from significant customers can be found in Note 14, “Segment Reporting,” included in this report.

For more information regarding our product revenue, see Note 6, “Revenue Recognition” included in Part II, Item 8, “Financial Statements and Supplementary Data” to our Form 10-K.

Contract Balances from Contracts with Customers

The following table provides information about receivables and deferred revenue from contracts with customers as of ~~June~~September 30, 2022 (amounts in thousands):

June 30,

December 31,

2022

2021

Balances from contracts with customers only:

Accounts receivable

$
121,050

$
117,420

Deferred revenue (included in accrued liabilities in
the consolidated balance sheets)

$
22,161

$
14,848

Revenue recognized during periods presented relating to:

The beginning deferred revenue balance

$
11,215

$
13,708


	September 30,		December 31,
	2022		2021
Balances from contracts with customers only:
Accounts receivable	$	117,645	$	117,420
Deferred revenue (included in accrued liabilities in the consolidated balance sheets)	$	19,465	$	14,848
Revenue recognized during periods presented relating to:
The beginning deferred revenue balance	$	12,989	$	13,708

The timing of revenue recognition, billings and cash collections results in the accounts receivable and deferred revenue balances on the Company’s consolidated balance sheets.

A contract asset is created when the Company satisfies a performance obligation by transferring a promised good to the customer. Contract assets may represent conditional or unconditional rights to consideration. The right is conditional and recorded as a contract asset if the Company must first satisfy another performance obligation in the contract before it is entitled to payment from the customer. Contract assets are transferred to billed receivables once the right becomes unconditional. If the Company has the unconditional right to receive consideration from the customer, the contract asset is accounted for as a billed receivable and presented separately from other contract assets. A right is unconditional if nothing other than the passage of time is required before payment of that consideration is due.

When consideration is received, or such consideration is unconditionally due, from a customer prior to transferring goods or services to the customer under the terms of a contract, a contract liability is recorded. Contract liabilities are recognized as revenue after control of the products or services is transferred to the customer and all revenue recognition criteria have been met.

Goodwill and Intangible Assets

Goodwill

Goodwill represents the difference between the purchase price and the estimated fair value of identifiable assets acquired and liabilities assumed. Goodwill acquired in a business combination and determined to have an indefinite useful life is not amortized, but instead is tested for impairment at least annually in accordance with ASC 350, “Intangibles – Goodwill and Other”.

The following table represents the change in the carrying value of goodwill for the ~~six~~nine months ended ~~June~~September 30, 2022 (amounts in thousands):


Balance as of December 31, 2021	$	860,362
Balance at December 31, 2021				$	860,362
Measurement period adjustment - BioFlex		(376	)		(376	)
Measurement period adjustment - Avitide		(1,784	)		(1,768	)
Cumulative translation adjustment		(3,874	)		(6,812	)
Balance as of June 30, 2022	$	854,328
Balance at September 30, 2022				$	851,406

During each of the fourth quarters of 2021, 2020 and 2019, the Company completed its annual impairment assessments and concluded that goodwill was not impaired in any of those years. The Company has not identified any “triggering” events which indicate an impairment of goodwill in the three and ~~six~~nine months ended ~~June~~September 30, 2022.

Intangible Assets

Intangible assets with a definitive life are amortized over their useful lives using the straight-line method, and the amortization expense is recorded within cost of product revenue and selling, general and administrative expenses in the Company’s statements of comprehensive income. Intangible assets and their related useful lives are reviewed at least annually to determine if any adverse conditions existed that would indicate the carrying value of these assets may not be recoverable. More frequent impairment assessments are conducted if certain conditions exist, including a change in the competitive landscape, any internal decisions to pursue new or different technology strategies, a loss of a significant customer, or a significant change in the marketplace, including changes in the prices paid for the Company's products or changes in the size of the market for the Company’s products. An impairment results if the carrying value of the asset exceeds the estimated fair value of the asset. If the estimate of an intangible asset’s remaining useful life is changed, the remaining carrying amount of the intangible asset is

amortized prospectively over the revised remaining useful life. The Company continues to believe that its intangible assets are recoverable at ~~June~~September 30, 2022.

Indefinite-lived intangible assets are reviewed for impairment at least annually. There has been 0no impairment of the Company’s intangible assets for the periods presented.

Intangible assets, net consisted of the following at ~~June~~September 30, 2022:


	June 30, 2022									September 30, 2022
	Gross Carrying Value		Accumulated Amortization			Net Carrying Value		Weighted Average Useful Life (in years)		Gross Carrying Value		Accumulated Amortization			Net Carrying Value		Weighted Average Useful Life (in years)
	(Amounts in thousands)									(Amounts in thousands)
Finite-lived intangible assets:
Technology - developed(1)	$	145,304	$	(25,862	)	$	119,442		17	$	189,627	$	(27,864	)	$	161,763		16
Patents		240		(240	)		0		8		240		(240	)		—		8
Customer relationships		253,221		(58,709	)		194,512		15		251,482		(61,681	)		189,801		15
Trademarks		7,675		(1,096	)		6,579		19		7,658		(1,202	)		6,456		19
Other intangibles		2,801		(1,826	)		975		4		2,772		(1,932	)		840		4
Total finite-lived intangible assets		409,241		(87,733	)		321,508		16		451,779		(92,919	)		358,860		16
Indefinite-lived intangible asset:
Trademarks		700		—			700		—		700		—			700		—
Total intangible assets	$	409,941	$	(87,733	)	$	322,208			$	452,479	$	(92,919	)	$	359,560

17(1)

Includes an upfront payment paid to DRS Daylight Solutions, Inc. ("Daylight") in September 2022 to exclusively license and commercialize rights to use certain technology and intellectual property which Daylight owns. The expected useful life of this technology is 15 years, which is the term of the Agreement and the period the Company expects to be able to utilize the license and which the technology will contribute directly to cash flows. See Note 9, "Commitments and Contingencies" for more information on this transaction.

Intangible assets consisted of the following at December 31, 2021:


	December 31, 2021									December 31, 2021
	Gross Carrying Value		Accumulated Amortization			Net Carrying Value		Weighted Average Useful Life (in years)		Gross Carrying Value		Accumulated Amortization			Net Carrying Value		Weighted Average Useful Life (in years)
	(Amounts in thousands)									(Amounts in thousands)
Finite-lived intangible assets:
Technology - developed	$	146,097	$	(21,553	)	$	124,544		17	$	146,097	$	(21,553	)	$	124,544		17
Patents		240		(240	)		0		8		240		(240	)		—		8
Customer relationships		254,699		(50,719	)		203,980		15		254,699		(50,719	)		203,980		15
Trademarks		7,699		(877	)		6,822		19		7,699		(877	)		6,822		19
Other intangibles		2,839		(1,611	)		1,228		4		2,839		(1,611	)		1,228		4
Total finite-lived intangible assets		411,574		(75,000	)		336,574		16		411,574		(75,000	)		336,574		16
Indefinite-lived intangible asset:
Trademarks		700		—			700		—		700		—			700		—
Total intangible assets	$	412,274	$	(75,000	)	$	337,274			$	412,274	$	(75,000	)	$	337,274

Amortization expense for finite-lived intangible assets was $6.6 million and $~~5.2~~5.7 million for each of the three months ended ~~June~~September 30, 2022 and 2021, respectively, and $~~13.2~~19.8 million and $~~10.4~~16.1 million for each of the ~~six~~nine months ended ~~June~~September 30,

2022 and 2021, respectively. As of ~~June~~September 30, 2022, the Company expects to record the following amortization expense in future periods (amounts in thousands):


	Estimated		Estimated
	Amortization		Amortization
For the Years Ended December 31,	Expense		Expense
2022 (remaining six months)	$	13,182
2022 (remaining three months)			$	7,316
2023		26,246		29,145
2024		25,661		28,559
2025		25,322		28,220
2026		25,322		28,220
2027 and thereafter		205,775		237,400
Total	$	321,508	$	358,860

Consolidated Balance Sheet Detail

Inventories, net

Inventories, net consists of the following:

June 30,

December 31,

2022

2021

(Amounts in thousands)

Raw materials

$
141,673

$
123,321

Work-in-process

7,126

8,119

Finished products

90,318

53,054

Total inventories, net

$
239,117

$
184,494


	September 30,		December 31,
	2022		2021
	(Amounts in thousands)
Raw materials	$	146,799	$	123,321
Work-in-process		7,692		8,119
Finished products		88,204		53,054
Total inventories, net	$	242,695	$	184,494

Property, Plant and Equipment

Property, plant and equipment consist of the following:


	June 30,			December 31,			September 30,			December 31,
	2022			2021			2022			2021
	(Amounts in thousands)						(Amounts in thousands)
Land	$	876		$	1,023		$	823		$	1,023
Buildings		679			764			637			764
Leasehold improvements		54,786			52,505			86,301			52,505
Equipment		75,132			70,983			80,398			70,983
Furniture, fixtures and office equipment		10,333			9,137			7,960			9,137
Computer hardware and software		27,655			22,380			28,405			22,380
Construction in progress		77,807			38,446			53,448			38,446
Other		504			443			387			443
Total property, plant and equipment		247,772			195,681			258,359			195,681
Less - Accumulated depreciation		(79,402	)		(70,717	)		(84,104	)		(70,717	)
Total property, plant and equipment, net	$	168,370		$	124,964		$	174,255		$	124,964

Depreciation expenses totaled $~~5.5~~6.1 million and $~~3.8~~4.3 million for each of the three months ended ~~June~~September 30, 2022 and 2021, respectively, and $~~10.7~~16.8 million and $~~7.0~~11.3 million for each of the ~~six~~nine months ended ~~June~~September 30, 2022 and 2021, respectively.

Accrued Liabilities

Accrued liabilities consist of the following:


	June 30,		December 31,		September 30,		December 31,
	2022		2021		2022		2021
	(Amounts in thousands)				(Amounts in thousands)
Employee compensation	$	28,232	$	42,147	$	33,776	$	42,147
Deferred revenue		22,161		14,848		19,465		14,848
Income taxes payable		4,937		4,984		3,569		4,984
Other		15,363		13,519		17,823		13,519
Total accrued liabilities	$	70,693	$	75,498	$	74,633	$	75,498

Convertible Senior Notes

0.375% Convertible Senior Notes due 2024

On July 19, 2019, the Company issued $287.5 million aggregate principal pursuant to the 2019 Notes, which includes the underwriters’ exercise in full of an option to purchase an additional $37.5 million aggregate principal amount of 2019 Notes (the “Notes Offering”). The net proceeds of the Notes Offering, after deducting underwriting discounts and commissions and other related offering expenses payable by the Company, were approximately $278.5 million. The 2019 Notes are senior, unsecured obligations of the Company, and bear interest at a rate of 0.375% per year. Interest is payable semi-annually in arrears on January 15 and July 15 of each year, beginning on January 15, 2020. The 2019 Notes will mature on July 15, 2024, unless earlier repurchased or converted in accordance with their terms.

During the ~~second~~third quarter of 2022, the closing price of the Company’s common stock exceeded 130% of the conversion price of the 2019 Notes for more than 20 trading days of the last 30 consecutive trading days of the quarter. As a result, the 2019 Notes are convertible at the option of the holders of the 2019 Notes during the ~~third~~fourth quarter of 2022, the quarter immediately following the quarter when the conditions are met, as stated in the terms of the 2019 Notes. These conditions have been met each quarter since the third quarter of 2020. As a result, $~~24,000~~25,000 aggregate principal amount of the 2019 Notes have been converted by the note holders since the issuance of the 2019 Notes, including $~~13,000~~14,000 in ~~the first half of~~ 2022. The conversions resulted in the issuance of a nominal number of shares of the Company’s common stock to the note holders. The Company continues to classify the carrying value of the 2019 Notes as current liabilities on the Company’s consolidated balance ~~sheet~~sheets at ~~June~~September 30, 2022.

Prior to the adoption of ASU 2020-06, the Company accounted for the 2019 Notes as a liability and equity component where the carrying value of the liability component was valued based on a similar debt instrument. In accounting for the issuance of the

2019 Notes, the Company separated the 2019 Notes into liability and equity components. The carrying value of the liability component was calculated as the present value of its cash flows using a discount rate of 4.5% based on comparative convertible transactions for similar companies. The carrying value of the equity component representing the conversion option was determined by deducting the fair value of the liability component from the par value of the 2019 Notes as a whole. The excess of the principal amount of the liability component over its carrying value amount, referred to as the debt discount, was amortized to interest expense on our consolidated statements of comprehensive income over the five-year term of the 2019 Notes. The equity component was not re-measured as long as it continued to meet the conditions for equity classification. The equity component related to the 2019 Notes recorded at issuance was $52.1 million, which was recorded in additional paid-in capital on the Company's consolidated balance sheets.

In accounting for the transaction costs related to the issuance of the 2019 Notes, the Company allocated the total costs incurred to the liability and equity components of the 2019 Notes using the same proportions as the initial carrying value of the 2019 Notes. Transaction costs related to the liability component were $7.4 million and are amortized to interest expense using the effective interest method over the five-year term of the 2019 Notes. Transaction costs attributable to the equity component were $1.6 million and are netted with the equity component of the 2019 Notes in stockholders' equity of the Company's consolidated balance sheets. Additionally, the Company recorded a net deferred tax liability of $11.4 million.

Effective January 1, 2022, the Company adopted ASU 2020-06. After adoption, the Company now accounts for the 2019 Notes as a single liability measured at amortized cost. As the equity component is no longer required to be split into a separate component, the Company recorded a net adjustment for the initial $50.4 million that was allocated to additional paid-in capital and $22.9 million of life-to-date interest expense recorded as amortization of debt discount. Additionally, the net deferred tax liability recorded for the 2019 Notes was reversed. The principal amount of the liability over its carrying amount is amortized to interest expense over the five-year term of the 2019 Notes. Since the 2019 Notes are classified as a single liability, there is no debt discount required to be amortized for the three and ~~six~~nine months ended ~~June~~September 30, 2022.

The net carrying value of the liability component of the 2019 Notes is as follows:


	June 30,			December 31,
	2022			2021			September 30, 2022			December 31, 2021
	(Amounts in thousands)						(Amounts in thousands)
0.375% Convertible Senior Notes due 2024:
Principal amount	$	287,476		$	287,489		$	287,475		$	287,489
Unamortized debt discount		0			(28,220	)		—			(28,220	)
Unamortized debt issuance costs		(3,764	)		(4,011	)		(3,310	)		(4,011	)
Net carrying amount	$	283,712		$	255,258		$	284,165		$	255,258

The following table sets forth total interest expense recognized related to the 2019 Notes:


	Three Months Ended						Six Months Ended
	June 30,						June 30,						Three Months Ended September 30,						Nine Months Ended September 30,
	2022			2021			2022			2021			2022			2021			2022			2021
	(Amounts in thousands)												(Amounts in thousands)
Contractual interest expense	$	269		$	269		$	539		$	539		$	270		$	270		$	809		$	809
Amortization of debt issuance costs		453			357			905			709			455			361			1,360			1,070
Amortization of debt discount		0			2,508			0			4,986			—			2,540			—			7,526
Total	$	722		$	3,134		$	1,444		$	6,234		$	725		$	3,171		$	2,169		$	9,405
Effective interest rate of the liability component		1.0	%		5.1	%		1.0	%		5.1	%		1.0	%		5.1	%		1.0	%		5.1	%

At ~~June~~September 30, 2022 and December 31, 2021, the carrying value of the 2019 Notes was $~~283.7~~284.2 million and $255.3 million, respectively, net of unamortized discount, and the fair value of the 2019 Notes was $~~432.3~~494.6 million and $678.5 million, respectively. The fair value of the 2019 Notes was determined based on the most recent trade activity of the 2019 Notes at ~~June~~September 30, 2022 and December 31, 2021.

Stockholders’ Equity

Stock Option and Incentive Plans

Under the Company’s current 2018 Stock Option and Incentive Plan (the “2018 Plan”), the number of shares of the Company’s common stock that ~~are~~were reserved and available for issuance is 2,778,000, plus the number of shares of common stock that were available for issuance under the Company’s previous equity plans. The shares of common stock underlying any awards under the 2018 Plan and previous equity plans (together, the “Plans”) that are forfeited, canceled or otherwise terminated (other than by exercise) shall be added back to the shares of stock available for issuance under the 2018 Plan. At ~~June~~September 30, 2022, ~~1,948,381~~1,953,159 shares were available for future grants under the 2018 Plan.

Stock-Based Compensation

For each of the three months ended ~~June~~September 30, 2022 and 2021, the Company recorded stock-based compensation expense of $~~7.0~~6.2 million and $~~7.1~~6.8 million, respectively, for share-based awards granted under the Plans. For the ~~six~~nine months ended ~~June~~September 30, 2022 and 2021, the Company recorded stock-based compensation expense of $~~14.9~~21.1 million and $~~13.7~~20.5 million,

respectively. The following table presents stock-based compensation expense in the Company’s consolidated statements of comprehensive income:


	Three Months Ended June 30,				Six Months Ended June 30,				Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021		2022		2021		2022		2021
	(Amounts in thousands)								(Amounts in thousands)
Cost of product revenue	$	615	$	449	$	1,237	$	955	$	610	$	489	$	1,847	$	1,444
Research and development		622		795		1,421		1,511		534		698		1,955		2,209
Selling, general and administrative		5,748		5,899		12,242		11,218		5,010		5,605		17,252		16,823
Total stock-based compensation	$	6,985	$	7,143	$	14,900	$	13,684	$	6,154	$	6,792	$	21,054	$	20,476

The 2018 Plan allows for the granting of incentive and nonqualified options to purchase shares of common stock, restricted stock and other equity awards. Employee grants under the Plans generally vest over a three to five-year period, with 20%-33% vesting on the first anniversary of the date of grant and the remainder vesting in equal yearly installments thereafter.

Nonqualified options issued to non-employee directors under the Plans generally vest over one year. In the first quarter of 2018, to create a longer-term retention incentive, the Company’s Compensation Committee granted long-term incentive compensation awards to its Chief Executive Officer, which consisted of both stock options and restricted stock units (“RSUs”) that are subject to time-based vesting over nine years. Options granted under the Plans have a maximum term of ten years from the date of grant and generally, the exercise price of the stock options equals the fair market value of the Company’s common stock on the date of grant. At ~~June~~September 30, 2022, options to purchase ~~648,546~~603,939 shares and ~~551,029~~532,256 stock units were outstanding under the Plans.

Stock Options

The Company uses the Black-Scholes option pricing model to calculate the fair value of stock option awards on the grant date, and the Company uses the value of the common stock as of the grant date to value RSUs. The Company measures stock-based compensation costs for stock options at the grant date based on the estimated fair value of the award. The Company recognizes expense on awards with service-based vesting over the employee’s requisite service period on a straight-line basis. The Company recognizes stock-based compensation expense for options that are ultimately expected to vest, and accordingly, such compensation expense has been adjusted for estimated forfeitures.

Information regarding option activity for the ~~six~~nine months ended ~~June~~September 30, 2022 under the Plans is summarized below:


	Shares			Weighted average exercise price		Weighted- Average Remaining Contractual Term (in Years)		Aggregate Intrinsic Value (in Thousands)		Shares			Weighted average exercise price		Weighted- Average Remaining Contractual Term (in Years)		Aggregate Intrinsic Value (in Thousands)
Options outstanding at December 31, 2021		625,107		$	54.15		6.29	$	131,707		625,107		$	54.15		6.29	$	131,707
Granted		47,838		$	180.82						47,838		$	180.82
Exercised		(16,399	)	$	28.20						(61,006	)	$	45.64
Forfeited/expired/cancelled		(8,000	)	$	193.86						(8,000	)	$	193.86
Options outstanding at June 30, 2022		648,546		$	62.42		6.09	$	67,377
Options exercisable at June 30, 2022		381,399		$	46.21		5.49	$	44,750
Vested and expected to vest at June 30, 2022(1)		632,147					6.08	$	65,687
Options outstanding at September 30, 2022											603,939		$	63.19		5.89	$	75,626
Options exercisable at September 30, 2022											341,192		$	46.89		5.28	$	48,042
Vested and expected to vest at September 30, 2022(1)											589,320					5.88	$	73,832

(1)

Represents the number of vested options as of ~~June~~September 30, 2022 plus the number of unvested options expected to vest as of ~~June~~September 30, 2022 based on the unvested outstanding options at ~~June~~September 30, 2022 adjusted for estimated forfeiture rates of 8% for awards granted to non-executive level employees and 3% for awards granted to executive level employees.

The aggregate intrinsic value in the table above represents the total pre-tax intrinsic value (the difference between the closing price of the common stock on ~~June~~September 30, 2022, the last business day of the ~~second~~third quarter of 2022, of $~~162.40~~187.11 per share and the exercise price of each in-the-money option) that would have been received by the option holders had all option holders exercised their options on ~~June~~September 30, 2022. The aggregate intrinsic value of stock options exercised during the ~~six~~nine months ended ~~June~~September 30, 2022 and 2021 was $~~2.4~~9.8 million and $~~6.0~~14.5 million, respectively.

The weighted average grant date fair value of options granted during the ~~six~~nine months ended ~~June~~September 30, 2022 and 2021 was $76.64 and $~~86.96~~88.01, respectively. The total fair value of stock options that vested during the ~~six~~nine months ended ~~June~~September 30, 2022 and 2021 was $~~2.7~~3.1 million and $~~2.5~~2.6 million, respectively.

Stock Units

The fair value of stock units is calculated using the closing price of the Company’s common stock on the date of grant. The Company recognizes expense on awards with service-based vesting over the employee’s requisite service period on a straight-line basis. The Company recognizes expense on performance-based awards over the vesting period based on the probability that the performance metrics will be achieved. Information regarding stock unit activity, which includes activity for RSUs and performance stock units, for the ~~six~~nine months ended ~~June~~September 30, 2022 under the Plans is summarized below:


	Shares			Weighted- Average Remaining Contractual Term (in Years)		Aggregate Intrinsic Value (in Thousands)		Shares			Weighted- Average Remaining Contractual Term (in Years)		Aggregate Intrinsic Value (in Thousands)
Unvested at December 31, 2021		606,685			3.07	$	160,674		606,685			3.07	$	160,674
Awarded		144,845							159,117
Vested		(175,647	)						(190,152	)
Forfeited/expired/cancelled		(24,854	)						(43,394	)
Unvested at June 30, 2022		551,029			3.00	$	89,487
Vested and expected to vest at June 30, 2022(1)		535,061			2.63	$	86,894
Unvested at September 30, 2022									532,256			2.93	$	99,590
Vested and expected to vest at September 30, 2022(1)									516,326			2.48	$	96,610

(1)

Represents the number of vested stock units as of ~~June~~September 30, 2022 plus the number of unvested stock units expected to vest as of ~~June~~September 30, 2022 based on the unvested outstanding stock units at ~~June~~September 30, 2022 adjusted for estimated forfeiture rates of 8% for awards granted to non-executive level employees and 3% for awards granted to executive level employees.

The aggregate intrinsic value in the table above represents the total pre-tax intrinsic value (equal to the closing price of the common stock on ~~June~~September 30, 2022, the last business day of the ~~second~~third quarter of 2022, of $~~162.40~~187.11 per share, as stock units do not

have an exercise price) that would have been received by the stock unit holders had all holders exercised on ~~June~~September 30, 2022. The aggregate intrinsic value of stock units vested during the ~~six~~nine months ended ~~June~~September 30, 2022 and 2021 was $~~37.5~~40.4 million and $~~35.8~~39.2 million, respectively.

The weighted average grant date fair value of stock units granted during the ~~six~~nine months ended ~~June~~September 30, 2022 and 2021 was $~~191.09~~191.55 and $~~206.15~~211.34, respectively. The total fair value of stock units that vested during the ~~six~~nine months ended ~~June~~September 30, 2022 and 2021 was $~~17.9~~19.7 million and $~~9.6~~10.8 million, respectively.

As of ~~June~~September 30, 2022, there was $~~70.4~~63.9 million of total unrecognized compensation cost related to unvested share-based awards. This cost is expected to be recognized over a weighted average remaining requisite service period of ~~3.01~~2.93 years. The Company expects ~~1,790,901~~1,786,671 unvested options and stock units to vest over the next five years.

12.

Earnings Per Share

The Company reports earnings per share (“EPS”) in accordance with ASC 260, “Earnings Per Share,” which establishes standards for computing and presenting EPS. Basic EPS is computed by dividing net income available to common shareholders by the weighted average number of common shares outstanding during the period. Diluted EPS is computed by dividing net income available to common shareholders by the weighted-average number of common shares and dilutive common share equivalents then outstanding. Potential common share equivalents consist of RSUs, performance stock units and the incremental common shares issuable upon the exercise of stock options. In periods when the Company has a net loss, stock awards are excluded from the calculation of EPS as their inclusion would have an antidilutive effect.

A reconciliation of basic and diluted weighted average shares outstanding is as follows:


	Three Months Ended June 30,				Six Months Ended June 30,				Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021		2022		2021		2022		2021
	(Amounts in thousands, except per share data)								(Amounts in thousands, except per share data)
Numerator:
Net income	$	49,861	$	36,233	$	96,825	$	65,683	$	40,405	$	33,498	$	137,230	$	99,181
Effect of dilutive securities:
Charges associated with convertible debt instruments, net of tax		0		0		387		0		—		—		387		—
Numerator for diluted earnings per share - net income available to common stockholders after the effect of dilutive securities	$	49,861	$	36,233	$	97,212	$	65,683	$	40,405	$	33,498	$	137,617	$	99,181

Denominator:
Weighted average shares used in computing net income per share - basic		55,444		54,931		55,399		54,868		55,498		55,015		55,432		54,918
Effect of dilutive shares:
Options and stock units		598		843		661		903		673		919		663		913
Convertible Senior Notes		676		1,012		1,779		1,052		1,131		1,373		1,501		1,180
Dilutive effect of unvested performance stock units		3		0		3		0		2		61		2		61
Dilutive potential common shares		1,277		1,855		2,443		1,956		1,806		2,353		2,166		2,154
Denominator for diluted earnings per share - adjusted weighted average shares used in computing net income per share - diluted		56,721		56,786		57,842		56,824		57,304		57,368		57,598		57,072

Earnings per share:
Basic	$	0.90	$	0.66	$	1.75	$	1.20	$	0.73	$	0.61	$	2.48	$	1.81
Diluted	$	0.88	$	0.64	$	1.68	$	1.16	$	0.71	$	0.58	$	2.39	$	1.74

At ~~June~~September 30, 2022, there were outstanding options to purchase ~~648,546~~603,939 shares of the Company’s common stock at a weighted average exercise price of $~~62.42~~63.19 per share and ~~551,029~~532,256 shares of common stock issuable upon the vesting of stock units, which include RSUs and performance stock units. For the three and ~~six~~nine months ended ~~June~~September 30, 2022, ~~325,685~~112,179 shares and ~~306,400~~149,187 shares, respectively, of the Company’s common stock were excluded from the calculation of diluted EPS because the exercise prices of the stock options were greater than or equal to the average price of the common shares and were therefore anti-dilutive.

At ~~June~~September 30, 2021, there were outstanding options to purchase ~~682,913~~658,600 shares of the Company’s common stock at a weighted average exercise price of $5$~~1.71~~54.93 per share and ~~618,618~~619,761 shares of common stock issuable upon the vesting of stock units, which include RSUs and performance stock units. For the three and ~~six~~nine months ended ~~June~~September 30, 2021, ~~69,388~~44,912 shares and 63,770 shares of the Company’s common stock were excluded from the calculation of diluted EPS because the exercise prices of the stock options were greater than or equal to the average price of the common shares and were therefore anti-dilutive.

In July 2019, the Company issued $287.5 million aggregate principal amount of the 2019 Notes. As provided by the terms of the indenture underlying the 2019 Notes, prior to March 4, 2022, conversion of the 2019 Notes could have been settled in cash, shares of the Company’s common stock or a combination thereof, at the Company’s election. On March 4, 2022, we entered into the Second Supplemental Indenture for the 2019 Notes, which irrevocably elected to settle the conversion of the 2019 Notes using a

2425

combination of cash and shares of the Company’s common stock, settling the par value of the 2019 Notes in cash and any excess conversion premium in shares.

As provided by the terms of the Second Supplemental Indenture underlying the 2019 Notes, the Company irrevocably elected to settle the conversion obligation for the 2019 Notes in a combination of cash and shares of the Company's common stock. This means the Company will settle the par value of the 2019 Notes in cash and any excess conversion premium in shares. As mentioned in Note 7, "Convertible Senior Notes," the Company adopted ASU 2020-06 effective January 1, 2022. Under ASU 2020-06, the Company is required to reflect the dilutive effect of the convertible securities by application of the "if-converted" method, which means the denominator of the EPS calculation would include the total number of shares assuming the 2019 Notes had been fully converted at the beginning of the period. Prior to March 4, 2022, the Company had the choice to settle the conversion of the 2019 Notes in cash, stock or a combination of the two. Therefore, from January 1, 2022 (the date the Company adopted ASU 2020-06) to March 4, 2022, the Company included 3,474,429 shares in the denominator of the EPS calculation, applying the if converted method. Subsequent to March 4, 2022, after the Second Supplemental Indenture became effective, the Company irrevocably elected to settle the conversion obligation for the 2019 Notes in a combination of cash and shares of the Company's common stock, and from March 5, 2022 forward, only the excess premium will be settled with shares. Under the if-converted method of calculating dilutive shares, the Company was also required to exclude amortization of debt issuance costs and interest charges applicable to the convertible debt from the numerator of the dilutive EPS calculation for the period from January 1, 2022 to March 4, 2022, as if the interest on convertible debt was never recognized for that period. For the ~~six~~nine months ended ~~June~~September 30, 2022, the Company excluded interest charges of $0.4 million (net of tax) from the numerator.

Prior to the adoption of ASU 2020-06, the Company applied the provisions of ASC 260, “Earnings Per Share,” Subsection 10-45-44, to determine the diluted weighted average shares outstanding as it related to the conversion spread on its convertible notes. Accordingly, the par value of the 2019 Notes was not included in the calculation of diluted income per share, but the dilutive effect of the conversion premium was considered in the calculation of diluted net income per share using the treasury stock method. The dilutive impact of the 2019 Notes was based on the difference between the Company’s current period average stock price and the conversion price of the 2019 Notes, provided there was a premium. Pursuant to this accounting standard, there was no dilution from the accreted principal of the 2019 Notes. For the three and ~~six~~nine months ended ~~June~~September 30, 2022, the dilutive effect of the conversion premium included in the calculation of diluted earnings was ~~676,166~~1,130,530 shares and ~~1,779,041~~1,500,717 shares, respectively. For the three and ~~six~~nine months ended ~~June~~September 30, 2021, the dilutive effect of the conversion premium included in the calculation of diluted earnings was ~~1,011,993~~1,373,341 shares and ~~1,052,337~~1,180,425 shares, respectively.

14.

Segment Reporting

The Company views its operations, makes decisions regarding how to allocate resources and manages its business as 1one reportable segment and one reporting unit. As a result, the financial information disclosed herein represents all of the material financial information related to the Company.

The following table represents the Company’s total revenue by geographic area (based on the location of the customer):

2526


	Three Months Ended						Six Months Ended						Three Months Ended						Nine Months Ended
	June 30,						June 30,						September 30,						September 30,
	2022			2021			2022			2021			2022			2021			2022			2021
Revenue by customers' geographic locations:
North America		45	%		41	%		43	%		42	%		42	%		44	%		42	%		42	%
Europe		35	%		40	%		39	%		39	%		35	%		42	%		38	%		40	%
APAC/Other		20	%		19	%		18	%		19	%		23	%		14	%		20	%		18	%
Total revenue		100	%		100	%		100	%		100	%		100	%		100	%		100	%		100	%

Concentrations of Credit Risk and Significant Customers

Financial instruments that subject the Company to significant concentrations of credit risk primarily consist of cash and cash equivalents, marketable securities and accounts receivable. Per the Company’s investment policy, cash equivalents and marketable securities are invested in financial instruments with high credit ratings and credit exposure to any one issue, issuer (with the exception of U.S. Treasury obligations) and type of instrument is limited. At ~~June~~September 30, 2022 and December 31, 2021, the Company had no investments associated with foreign exchange contracts, options contracts or other foreign hedging arrangements.

Concentration of credit risk with respect to accounts receivable is limited to customers to whom the Company makes significant sales. While a reserve for the potential write-off of accounts receivable is maintained, the Company has not written off any significant accounts to date. To control credit risk, the Company performs regular credit evaluations of its customers’ financial condition.

Revenue from customers that represented 10% or more of the Company's total revenue for the periods presented in our consolidated statements of comprehensive income came from sales to Pfizer Inc. during the three months ended September 30, 2021 only, which generated $19.1 million, or 11% of the Company's total revenue for the period. There was 0no revenue from customers that represented 10% or more of the Company's total revenue for any of the ~~three and six months ended June 30, 2022 and 2021.~~other periods presented.

No accounts receivable balance from a specific customer represented 10% or more of the Company's total trade accounts receivable at ~~June~~September 30, 2022. Significant accounts receivable balances representing 10% or more of the Company’s total trade accounts receivable and royalties at December 31, 2021 came from our accounts receivable balance outstanding with Pfizer Inc., which was 14% of our total accounts receivable and other receivable balance.

ITEM 2. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

Repligen and its subsidiaries, collectively doing business as Repligen Corporation (“Repligen”, “we”, “our”, or the “Company”) is a global life sciences company that develops and commercializes highly innovative bioprocessing technologies and systems that increase efficiencies and flexibility in the process of manufacturing biological drugs.

As the overall market for biologics continues to grow and expand, our customers – primarily large biopharmaceutical companies and contract development and manufacturing organizations – face critical production cost, capacity, quality and time pressures. Built to address these concerns, our products are helping to set new standards for the way biologics are manufactured. We are committed to inspiring advances in bioprocessing as a trusted partner in the production of critical biologic drugs – including monoclonal antibodies (“mAb”), recombinant proteins, vaccines and cell and gene therapies ("C&GT") – that are improving human health worldwide. For more information regarding our business, products and acquisitions, see Part I, Item 1, “Business” included in our 2021 Annual Report on Form 10-K (“Form 10-K”), which was filed with the Securities and Exchange Commission (“SEC”) on February 17, 2022.

We currently operate as one bioprocessing business, with a comprehensive suite of products to serve both upstream and downstream processes in biological drug manufacturing. Building on over 40 years of industry expertise, we have developed a broad and diversified product portfolio that reflects our passion for innovation and the customer-first culture that drives our entire organization. We continue to capitalize on opportunities to maximize the value of our product platform through both organic growth initiatives (internal innovation and commercial leverage) and targeted acquisitions.

As a result of our global presence, a significant portion of our revenue and expenses is denominated in currencies other than the U.S. dollar. We are therefore subject to non-U.S. currency risks and non-U.S. exchange exposure. Exchange rates can be volatile and a substantial weakening or strengthening of foreign currencies against the U.S. dollar could increase or reduce our revenue and gross profit margin and impact the comparability of results from period to period.

We have experienced, and expect to continue to experience, cost inflation, primarily in raw materials, and other supply chain costs, as a result of global macroeconomic trends, including the conflict between Russia and Ukraine, government-mandated actions in response to the novel coronavirus pandemic ("COVID-19"), and labor shortages. Actions taken to mitigate supply chain disruptions and inflation, including price increases and productivity improvements, have generally been successful in offsetting the impact of these trends. In addition, decreasing demand for COVID-19 vaccination is driving a reduction in future demand of our products related to these vaccines. We expect that these trends will continue to impact our results for the remainder of 2022 and into 2023.

On September 19, 2022, we entered into a 15-year exclusive License Agreement ("Agreement") with DRS Daylight Solutions, Inc. ("Daylight"), giving us exclusive license and commercialization rights to use certain technology and intellectual property subject to conditions set forth in the Agreement. We agreed to pay Daylight (i) an initial, one-time, non-refundable, non-creditable upfront cash payment and (ii) quarterly royalty payments as defined in the Agreement.

On November 29, 2021, the Company entered into an Equity Purchase Agreement with Bio-Flex Solutions, L.L.C. ("BioFlex"), Newton T&M Corp. ("NTM") and each of Ralph Meola and Jason Nisler, to acquire 100% of the outstanding securities of BioFlex and NTM (collectively, the “NTM Acquisition”). The transaction closed on December 16, 2021.

NTM Acquisition complements and expands our filtration offering paths as the industry migrates to single-use flow paths solutions for mAb, vaccine and C&GT applications, with a focus on single-use fluid management components, including single-use clamps, adapters, end caps and hose assemblies. The NTM Acquisition streamlines and increases control over many components in our single-use supply chain which ultimately should drive reduced lead-times for our customers in the coming years.

On September 16, 2021, we entered into an Agreement and Plan of Merger and Reorganization (“Avitide Merger Agreement”) with Avalon Merger Sub, Inc., a Delaware corporation and a wholly owned direct subsidiary of the Company, Avalon Merger Sub LLC, a Delaware limited liability company and a wholly owned direct subsidiary, and Shareholder Representative Services LLC, a Colorado limited liability company, solely in its capacity as the representative, agent and attorney-in-fact of Avitide's securityholders to purchase Avitide. The transaction closed on September 20, 2021 on the terms set forth in the Avitide Merger Agreement.

Avitide, which is headquartered in Lebanon, New Hampshire, offers diverse libraries and leading technology in affinity ligand discovery and development, resulting in best-in-class ligand discovery and development lead-times. The acquisition gives us a new platform for affinity resin development, including C&GT, and advances and expands our proteins franchise to address the unique purification needs of gene therapies and other emerging modalities.

On June 22, 2021, we entered into a Stock Purchase Agreement with Polymem S.A. (“Polymem”), a company organized under the laws of France, and Jean-Michel Espenan and Franc Saux, acting together jointly and severally as the representatives of the sellers, which subsequently closed on July 1, 2021.

Polymem, which is headquartered in Toulouse, France, is a manufacturer of hollow fiber membranes, membrane modules and systems for industrial and bioprocessing applications. Polymem products will complement and expand Repligen’s portfolio of hollow fiber systems and consumables. The acquisition substantially increases our membrane and module manufacturing capacity and establishes a world-class center of excellence in Europe to address the accelerating global demand for these innovative products.

A “critical accounting policy” is one which is both important to the portrayal of our financial condition and results and requires management’s most difficult, subjective or complex judgments, often as a result of the need to make estimates about the effect of matters that are inherently uncertain. For a description of our critical accounting policies that affect our more significant judgments and estimates used in the preparation of our consolidated financial statements, refer to Management’s Discussion and Analysis of Financial Condition and Results of Operations and our significant accounting policies in Note 2, "Summary of Significant Accounting Policies",to the consolidated financial statements included in our Form 10-K.

The following discussion of the financial condition and results of operations should be read in conjunction with the accompanying consolidated financial statements and the related footnotes thereto.

Total revenue for the three and ~~six~~nine months ended ~~June~~September 30, 2022 and 2021 were as follows:

Since 2016, we have been increasingly focused on selling our products directly to customers in the pharmaceutical industry and to our contract manufacturers. These direct sales represented approximately ~~89%~~86% and ~~83%~~82% of our product revenue for each of the three months ended ~~June~~September 30, 2022 and 2021, respectively, and represented ~~88%~~87% and 82% of our product revenue for each of the ~~six~~nine months ended ~~June~~September 30, 2022 and 2021, respectively. ~~We expect that direct sales will continue to account for an increasing percentage of our product revenues, as the largest customer of our OEM products diversified its supply chain in 2020.~~ Sales of our bioprocessing products can be impacted by the timing of large-scale production orders and the regulatory approvals for such antibodies, which may result in significant quarterly fluctuations.

Revenues from our filtration franchise include the sales of our XCell ATF® systems and consumables; Spectrum filtration systems, including KrosFlo®; SIUS® filtration products and systems; the fluid management assemblies and components offered by Engineered Molding Technology LLC, Non-Metallic Solutions, Inc., ARTeSYN Biosolutions ~~Holdings~~ Ireland Limited ("ARTeSYN") and BioFlex, the latter of which was acquired on December 16, 2021; the hollow fiber membrane technology offered by Polymem, which we acquired on July 1, 2021; and our ARTeSYN filtration systems. Revenue from our chromatography products includes the sale of our OPUS pre-packed chromatography columns, ELISA test kits and chromatography systems from Spectrum and ARTeSYN. Revenue from proteins products includes the sale of our Protein A ligands and cell culture growth factors, and sales of affinity products, including adeno-associated virus resins offered by Avitide,

which we acquired on September 20, 2021. Revenue from our process analytics products includes the sale of our SoloVPE®, FlowVPE® and FlowVPX® systems, consumables and service. Other revenue primarily consists of sales of our operating room products to hospitals as well as freight revenue.

During the three and ~~six~~nine months ended ~~June~~September 30, 2022, product revenue increased by ~~$44.7~~$22.5 million, or ~~27.4%~~12.6% and ~~$108.3~~$130.8 million, or ~~35.4%~~27.0%, respectively, as compared to the same periods of 2021, with ~~exceptionally~~ robust demand for our filtration, chromatography and process analytics ~~products.~~products in mAb and C&GT manufacturing, which are not related to the manufacturing of COVID-19 vaccines. There is continued adoption of our products by key bioprocessing customers across all key product ~~lines. Since the second quarter of 2020,~~lines, though we ~~began to experience accelerated~~are seeing a deceleration in demand ~~across all of our franchises due to the critical needs of~~from customers ~~working~~focused on the novel coronavirus pandemic (“COVID-19”) vaccines. However, decreasing demand for vaccination is driving a reduction in future demand of our products from these customers and the recognition of future revenue related to COVID-19. In addition, we have recently seen an increased demand for C&GT and mAb manufacturing.manufacturing COVID-19 vaccinations. We also experienced an increase in revenue during the three and ~~six~~nine months ended ~~June~~September 30, 2022, compared to the same periods of 2021, due to our 2021 acquisitions of Polymem, Avitide and BioFlex, which were acquired in ~~the second half of~~July 2021, September 2021 and December 2021, respectively, and for which ~~there was no comparable amounts~~revenues related to these acquisitions were included in ~~the three and six months ended June 30, 2021.~~our results of operations from their respective date of acquisition.

Royalty revenues in the three and ~~six~~nine months ended ~~June~~September 30, 2022 and 2021 relate to royalties received from a third-party systems manufacturer associated with our OPUS PD chromatography columns. Royalty revenues are variable and are dependent on sales generated by our partner.

Total costs and operating expenses for the three and ~~six~~nine months ended ~~June~~September 30, 2022 and 2021 were comprised of the following:


	Three Months Ended June 30,					Increase/(Decrease)						Six Months Ended June 30,					Increase/(Decrease)						Three Months Ended September 30,					Increase/(Decrease)						Nine Months Ended September 30,					Increase/(Decrease)
	2022			2021		$ Change			% Change			2022			2021		$ Change			% Change			2022			2021		$ Change			% Change			2022			2021		$ Change			% Change
	(Amounts in thousands, except for percentage data)																						(Amounts in thousands, except for percentage data)
Cost of product revenue	$	86,260		$	61,990	$	24,270			39.2	%	$	168,616		$	121,737	$	46,879			38.5	%	$	86,514		$	75,495	$	11,019			14.6	%	$	255,130		$	197,232	$	57,898			29.4	%
Research and development		10,440			8,389		2,051			24.4	%		22,595			16,001		6,594			41.2	%		10,228			9,154		1,074			11.7	%		32,823			25,155		7,668			30.5	%
Selling, general and administrative		54,649			44,341		10,308			23.2	%		108,949			83,436		25,513			30.6	%		53,643			48,373		5,270			10.9	%		162,592			131,809		30,783			23.4	%
Contingent Consideration		(6,884	)		—		(6,884	)		(100.0	%)		(9,295	)		—		(9,295	)		(100.0	%)		(2,309	)		—		(2,309	)		(100.0	%)		(11,604	)		—		(11,604	)		(100.0	%)
Total costs and operating expenses	$	144,465		$	114,720	$	29,745			25.9	%	$	290,865		$	221,174	$	69,691			31.5	%	$	148,076		$	133,022	$	15,054			11.3	%	$	438,941		$	354,196	$	84,745			23.9	%

Cost of product revenue increased ~~39.2%~~14.6% and ~~38.5%~~29.4% in the three and ~~six~~nine months ended ~~June~~September 30, 2022, respectively, compared to the same periods of 2021, due primarily to the increase in product revenue mentioned above and costs associated with higher product volume. ~~In addition,~~Also, in order to support our growth and demand for our products, we continue to invest in our manufacturing infrastructure through an increase in headcount related to manufacturing and occupancy costs. In addition, we experienced cost inflation, primarily in raw materials as well as freight charges due to increased fuel costs and ~~import duties increased~~carrier market conditions, during the three and ~~six~~nine months ended ~~June~~September 30, 2022, compared to the same periods of ~~2021, due to increased fuel costs and carrier market conditions.~~2021. Our depreciation expense increased during the three and ~~six~~nine months ended ~~June~~September 30, 2022, as compared to the same periods of 2021, asdue to manufacturing equipment ~~was~~being placed into service ~~during the second half of 2021.~~throughout 2021 and 2022. In addition, cost of product revenue increased for the three ~~and six~~ months ended ~~June~~September 30, 2022 due to the ~~addition~~acquisitions of Avitide and BioFlex in September 2021 and December 2021, respectively, and for which expenses related to these acquisitions were included in our results of operations from their respective dates of acquisition. Cost of product revenue increased for the nine months ended September 30, 2022 due to the acquisitions of Polymem, Avitide and BioFlex ~~during~~in the second half of ~~2021 for which there were no comparable costs during the three and six months ended June 30,~~ 2021.

Gross margin was ~~58.5%~~56.9% and ~~62.0%~~57.6% in the three months ended ~~June~~September 30, 2022 and 2021, respectively. The reduction in gross margin in the three months ended ~~June~~September 30, 2022, as compared to the same period of 2021, is due primarily to the increase in manufacturing and employee-related costs from a rise in manufacturing headcount, an increase in occupancy costs due to added capacity, an increase in depreciation expense, and an increase in freight charges ~~and import duties mentioned above.~~from cost inflation.

Gross margin was ~~59.3%~~58.5% and ~~60.2%~~59.3% in the ~~six~~nine months ended ~~June~~September 30, 2022 and 2021, respectively. The reduction in gross margin in the ~~six~~nine months ended ~~June~~September 30, 2022, as compared to the same period of 2021, is due primarily to the increase in employee-related costs from a rise in manufacturing headcount, an increase in occupancy costs due to added capacity in 2021 and 2022 and an increase in depreciation expense, as mentioned above. The gross margin for the ~~six~~nine months ended ~~June~~September 30, 2021 also includes $1.6 million of amortization of inventory step-up associated with the ARTeSYN Acquisition in December 2020. Gross margins may fluctuate in future quarters based on actual production volume and product mix.

Research and development (“R&D”) expenses are related to bioprocessing products, which include personnel, supplies and other research expenses. Due to the ~~size of the Company and the~~ fact that these various programs share personnel and fixed costs, we do not track all of our expenses or allocate any fixed costs by program, and therefore, have not provided historical costs incurred by project.

R&D expenses increased ~~$2.1~~$1.1 million, or ~~24.4%~~11.7% and ~~$6.6~~$7.7 million, or ~~41.2%~~30.5%, during the three and ~~six~~nine months ended ~~June~~September 30, 2022, respectively, compared to the same periods of 2021. The increase during the periods is primarily due to increased spending on new product development, increased employee-related costs due to additional headcount, increased depreciation related to R&D assets that were put into service and ~~investments~~increased occupancy costs due to added capacity in ~~newly acquired businesses,~~2021 and 2022. In addition, the increase in R&D costs for ~~which there were no comparable costs in~~ the three and ~~six~~nine months ended ~~June~~September 30, ~~2021. The increase during~~2022, as compared to the same

periods ~~is also~~of 2021, was due to the costs related to our 2021 acquisitions, primarily Polymem and Avitide in ~~part to increased development project-related expenses~~July 2021 and ~~employee-related costs.~~September 2021, respectively.

R&D expense also includes payments made to expand our proteins product offering through our development agreement with Navigo Proteins GmbH (“Navigo”). Such expenses were ~~$0.7~~$0.3 million and ~~$1.1~~$1.4 million, respectively, for the three and ~~six~~nine months ended ~~June~~September 30, 2022, as compared to ~~$0.3~~$0.5 million and ~~$0.6~~$1.3 million, respectively for the same periods in 2021, in the form of milestone payments to Navigo.

We expect our R&D expenses for the remainder of 2022 to gradually increase ~~each quarter~~ to support new product development.

Selling, general and administrative (“SG&A”) expenses include the costs associated with selling our commercial products and costs required to support our marketing efforts, including legal, accounting, patent, shareholder services, amortization of intangible assets and other administrative functions.

During the three and ~~six~~nine months ended ~~June~~September 30, 2022, SG&A costs increased by ~~$10.3~~$5.3 million, or ~~23.2%~~10.9%, and ~~$25.5~~$30.8 million, or ~~30.6%~~23.4%, respectively, as compared to the same periods of 2021. The increases are partially due to the continued expansion of our customer-facing activities to drive sales of our bioprocessing products, and the continued buildout of our administrative infrastructure, primarily through increased headcount, to support expected future growth. In addition, SG&A costs increased for the three ~~and six~~ months ended ~~June~~September 30, 2022 due to the addition of Avitide and BioFlex in September 2021 and December 2021, respectively, for which the costs were not fully comparable in the three months ended September 30, 2021. SG&A costs increased for the nine months ended September 30, 2022 due to the addition of Polymem, Avitide and BioFlex during the second half of ~~2021, for which there~~2021. A full nine months of costs are ~~no comparable costs~~included in SG&A expenses in 2022 from these acquisitions, but only from the ~~three and six months ended June 30,~~date of acquisition in 2021.

Contingent consideration expense represents the change in fair value of the contingent consideration obligation included in current and noncurrent contingent consideration on the consolidated balance sheets as of the end of each period. Re-measurement of the contingent consideration obligation is done each quarter and the carrying value of the obligation is adjusted to the current fair value through our consolidated statements of comprehensive income. We recorded an adjustment to the fair value of the contingent consideration obligation for the three and ~~six~~nine months ended ~~June~~September 30, 2022 of ~~($6.9)~~$(2.3) million and ($~~9.3)~~11.6) million, respectively.


	Three Months Ended June 30,						Increase/(Decrease)						Six Months Ended June 30,						Increase/(Decrease)						Three Months Ended September 30,						Increase/(Decrease)						Nine Months Ended September 30,						Increase/(Decrease)
	2022			2021			$ Change			% Change			2022			2021			$ Change			% Change			2022			2021			$ Change			% Change			2022			2021			$ Change			% Change
	(Amounts in thousands, except for percentage data)																								(Amounts in thousands, except for percentage data)
Investment income	$	708		$	41		$	667			1626.8	%	$	785		$	93		$	692			744.1	%	$	2,177		$	44		$	2,133			4847.7	%	$	2,962		$	137		$	2,825			2062.0	%
Interest expense		(271	)		(2,787	)		2,516			(90.3	%)		(563	)		(5,541	)		4,978			(89.8	%)		(329	)		(2,859	)		2,530			(88.5	%)		(892	)		(8,400	)		7,508			(89.4	%)
Amortization of debt issuance costs		(453	)		(357	)		(96	)		26.9	%		(905	)		(709	)		(196	)		27.6	%		(455	)		(361	)		(94	)		26.0	%		(1,360	)		(1,070	)		(290	)		27.1	%
Other expenses		(3,396	)		(779	)		(2,617	)		335.9	%		(3,798	)		(1,003	)		(2,795	)		278.7	%		(6,591	)		(786	)		(5,805	)		738.5	%		(10,389	)		(1,789	)		(8,600	)		480.7	%
Total other expense, net	$	(3,412	)	$	(3,882	)	$	470			(12.1	%)	$	(4,481	)	$	(7,160	)	$	2,679			(37.4	%)	$	(5,198	)	$	(3,962	)	$	(1,236	)		31.2	%	$	(9,679	)	$	(11,122	)	$	1,443			(13.0	%)

Investment income includes income earned on invested cash balances. Our investment income increased by ~~$0.7~~$2.1 million for the three and ~~six~~nine months ended ~~June~~September 30, 2022, compared to the same periods of 2021 due to an increase in interest rates on average invested cash balances since ~~June~~September 30, 2021. We expect investment income to vary based on changes in the amount of funds invested and fluctuation of interest rates.

Interest expense in the three and ~~six~~nine months ended ~~June~~September 30, 2022 and 2021 is primarily from our 0.375% Convertible Senior Notes due 2024 (the “2019 Notes”), which were issued in July 2019. Interest expense for the three and ~~six~~nine months ended ~~June~~September 30, 2022 includes the contractual coupon interest on the 2019 Notes. For the three and ~~six~~nine months ended ~~June~~September 30, 2021, interest expense includes the amortization of the debt discount as well as the contractual coupon interest. As a result of our adoption of ASU 2020-06, "Debt - Debt with Conversion Other Options (Subtopic 470-20) and Derivatives and Hedging - Contracts in Entity's Own Equity (Subtopic 815-40)," effective January 1, 2022, the equity portion of the debt conversion feature recorded upon the issuance of the 2019 Notes, or the debt discount, was reversed along with the total amortization taken on that discount. Since there was no debt discount, no amortization was taken in the three and ~~six~~nine months ended ~~June~~September 30, 2022.

In accounting for the transaction costs related to the issuance of the 2019 Notes, the Company allocated the total costs incurred to the liability and equity components of the 2019 Notes based on their relative values. Transaction costs attributable to the liability component are amortized to amortization of debt issuance costs on the consolidated statements of comprehensive income. Amortization of debt issuance costs increased during the three and ~~six~~nine months ended ~~June~~September 30, 2022, as compared to the same periods of 2021. This is a result of the decrease in the balance of debt issuance costs that are being amortized. As these costs decrease, the carrying value of the debt increases and interest calculated based on the carrying value increases as well.

The change in other expenses, net during the three and ~~six~~nine months ended ~~June~~September 30, 2022, compared to the same periods of 2021, is primarily attributable to realized foreign currency losses related to transactions with customers and vendors.

Income tax provision for the three and ~~six~~nine months ended ~~June~~September 30, 2022 and 2021 was as follows:

For the three and ~~six~~nine months ended ~~June~~September 30, 2022, we recorded an income tax provision of ~~$9.9~~$7.1 million and ~~$21.9~~$28.9 million, respectively. The effective tax rate was ~~16.6%~~14.9% and ~~18.4%~~17.4% for the three and ~~six~~nine months ended ~~June~~September 30, 2022, respectively, and is based upon the estimated income for the year ending December 31, 2022 and the composition of income in different jurisdictions. The difference in effective tax rates between the periods was primarily due to higher ~~income before income taxes, lower~~benefits recognized on business tax credits and windfall benefits recognized on stock option exercises and the vesting of stock ~~units partially offset by lower U.S. taxation of foreign earnings.~~units. Our effective tax rate for the three and ~~six~~nine months ended ~~June~~September 30, 2022 was lower than the U.S. statutory rate of 21% primarily due to business tax credits, ~~and~~ windfall benefits on stock option exercises and the vesting of stock ~~units.~~units, and benefits from foreign-derived intangible income. For the three and ~~six~~nine months ended ~~June~~September 30, 2021, we recorded an income tax provision of ~~$8.1~~$7.7 million and ~~$11.8~~$19.5 million, respectively. The effective tax rate was ~~18.3%~~18.8% and ~~15.2%~~16.4% for the three and ~~six~~nine months ended ~~June~~September 30, 2021, respectively, and is based upon the estimated income for the year ending December 31, 2021 and the composition of income in different jurisdictions. Our effective tax rate for the three and ~~six~~nine months ended ~~June~~September 30, 2021 was lower than the U.S. statutory rate of 21% primarily due to business tax credits and windfall benefits on stock option exercise and the vesting of stock units.

On August 16, 2022, the United States enacted the Inflation Reduction Act of 2022 ("Inflation Reduction Act"), which, among other things, implements a 15% alternative minimum tax on global adjusted financial statement income of certain large corporations, a 1% excise tax on net stock repurchases and several tax incentives to promote clean energy and will become

effective beginning in 2023. We evaluated the provisions of the Inflation Reduction Act and we believe that as of September 30, 2022, no provision had a material effect on our consolidated financial position or results of operations.

We provide non-GAAP adjusted income from operations; adjusted net income; and adjusted EBITDA as supplemental measures to GAAP, measures regarding our operating performance. These financial measures exclude the items detailed below and, therefore, have not been calculated in accordance with GAAP. A detailed explanation and a reconciliation of each non-GAAP financial measure to its most comparable GAAP financial measure are provided below.

We include this financial information because we believe these measures provide a more accurate comparison of our financial results between periods and more accurately reflect how management reviews its financial results. We excluded the impact of certain acquisition-related items because we believe that the resulting charges do not accurately reflect the performance of our ongoing operations for the period in which such charges are incurred.

Non-GAAP adjusted income from operations is measured by taking income from operations as reported in accordance with GAAP and excluding inventory step-up charges, acquisition and integration costs, contingent consideration fair value adjustments, and intangible amortization booked through our consolidated statements of comprehensive income. The following is a reconciliation of income from operations in accordance with GAAP to non-GAAP adjusted income from operations for the three and ~~six~~nine months ended ~~June~~September 30, 2022 and 2021:


	Three Months Ended June 30,					Six Months Ended June 30,					Three Months Ended September 30,					Nine Months Ended September 30,
	2022			2021		2022			2021		2022			2021		2022			2021
	(Amounts in thousands)										(Amounts in thousands)
GAAP income from operations	$	63,168		$	48,240	$	123,168		$	84,623	$	52,665		$	45,194	$	175,833		$	129,817
Non-GAAP adjustments to income from operations:
Inventory step-up charges		—			—		—			1,598		—			270		—			1,868
Acquisition and integration costs		2,702			3,218		5,891			5,769		1,251			5,824		7,142			11,593
Contingent consideration		(6,884	)		—		(9,295	)		—		(2,309	)		—		(11,604	)		—
Intangible amortization		6,572			5,161		13,165			10,323		6,547			5,677		19,712			16,001
Non-GAAP adjusted income from operations	$	65,558		$	56,619	$	132,929		$	102,313	$	58,154		$	56,965	$	191,083		$	159,279

Non-GAAP adjusted net income and adjusted earnings per share is measured by taking net income as reported in accordance with GAAP and excluding acquisition and integration costs, intangible amortization, inventory step-up charges, loss on conversion of debt, non-cash interest expense, amortization of debt issuance costs, contingent consideration fair value adjustments and the tax effects of these items.

The following are reconciliations of net income and fully diluted earnings per share in accordance with

GAAP to non-GAAP adjusted net income and adjusted fully diluted earnings per share for the three and ~~six~~nine months ended ~~June~~September 30, 2022 and 2021:


	Three Months Ended June 30,												Three Months Ended September 30,
	2022						2021						2022						2021
				Fully Diluted						Fully Diluted						Fully Diluted						Fully Diluted
				Earnings per						Earnings per						Earnings per						Earnings per
	Amount			Share*			Amount			Share*			Amount			Share*			Amount			Share*
	(Amounts in thousands, except per share data)												(Amounts in thousands, except per share data)
GAAP net income	$	49,861		$	0.88		$	36,233		$	0.64		$	40,405		$	0.71		$	33,498		$	0.58
Non-GAAP adjustments to net income:
Inventory step-up charges		—			—			—			—			—			—			270			0.00
Acquisition and integration costs		2,702			0.05			3,218			0.06			1,512			0.03			5,824			0.10
Contingent consideration		(6,884	)		(0.12	)		—			—			(2,309	)		(0.04	)		—			—
Intangible amortization		6,572			0.12			5,161			0.09			6,547			0.11			5,677			0.10
Loss on conversion of debt		—			—			4			0.00			—			—			1			0.00
Amortization of debt issuance costs(1)		453			0.01			357			0.01			455			0.01			361			0.01
Non-cash interest expense(1)		—			—			2,505			0.04			—			—			2,541			0.04
Tax effect of non-GAAP charges		(1,317	)		(0.02	)		(2,615	)		(0.05	)		(2,241	)		(0.04	)		(3,467	)		(0.06	)
Non-GAAP adjusted net income	$	51,387		$	0.91		$	44,863		$	0.79		$	44,369		$	0.77		$	44,705		$	0.78


	Six Months Ended June 30,												Nine Months Ended September 30,
	2022						2021						2022						2021
				Fully Diluted						Fully Diluted						Fully Diluted						Fully Diluted
				Earnings per						Earnings per						Earnings per						Earnings per
	Amount			Share			Amount			Share			Amount			Share*			Amount			Share*
	(Amounts in thousands, except per share data)												(Amounts in thousands, except per share data)
GAAP net income	$	96,825		$	1.68		$	65,683		$	1.16		$	137,230		$	2.39		$	99,181		$	1.74
Non-GAAP adjustments to net income:
Inventory step-up charges		—			—			1,598			0.03			—			—			1,868			0.03
Acquisition and integration costs		5,891			0.10			5,769			0.10			7,403			0.13			11,593			0.20
Contingent consideration		(9,295	)		(0.16	)		—			—			(11,604	)		(0.20	)		—			—
Intangible amortization		13,165			0.23			10,323			0.18			19,712			0.34			16,001			0.28
Loss on conversion of debt		—			—			4			0.00			—			—			6			0.00
Amortization of debt issuance costs(1)		905			0.01			709			0.01			1,360			0.02			1,070			0.02
Non-cash interest expense		—			—			4,981			0.09			—			—			7,522			0.13
Tax effect of non-GAAP charges		(2,359	)		(0.04	)		(5,437	)		(0.10	)		(4,600	)		(0.08	)		(8,904	)		(0.16	)
Non-GAAP adjusted net income	$	105,132		$	1.82		$	83,630		$	1.47		$	149,501		$	2.61		$	128,337		$	2.25

Adjusted EBITDA is measured by taking net income as reported in accordance with GAAP, excluding investment income, interest expense, taxes, depreciation and amortization, acquisition and integration costs, inventory step-up charges, loss on conversion of debt and contingent consideration fair value adjustments booked through our consolidated statements of

comprehensive income. The following is a reconciliation of net income in accordance with GAAP to adjusted EBITDA for the three and ~~six~~nine months ended ~~June~~September 30, 2022 and 2021:


	Three Months Ended June 30,						Six Months Ended June 30,						Three Months Ended September 30,						Nine Months Ended September 30,
	2022			2021			2022			2021			2022			2021			2022			2021
	(Amounts in thousands)												(Amounts in thousands)
GAAP net income	$	49,861		$	36,233		$	96,825		$	65,683		$	40,405		$	33,498		$	137,230		$	99,181
Non-GAAP EBITDA adjustments to net income:
Investment income		(708	)		(41	)		(785	)		(93	)		(2,177	)		(44	)		(2,962	)		(137	)
Interest expense		271			282			563			560			329			318			892			878
Non-cash interest expense(1)		—			2,505			—			4,981			—			2,541			—			7,522
Amortization of debt issuance costs		453			357			905			709			455			361			1,360			1,070
Income tax provision		9,895			8,125			21,862			11,780			7,062			7,734			28,924			19,514
Depreciation		5,500			3,797			10,713			7,052			6,097			4,308			16,810			11,360
Intangible amortization		6,599			5,190			13,220			10,379			6,575			5,705			19,795			16,084
EBITDA	$	71,871		$	56,448		$	143,303		$	101,051		$	58,746		$	54,421		$	202,049		$	155,472
Other non-GAAP adjustments:
Inventory step-up charges		—			—			—			1,598			—			270			—			1,868
Acquisition and integration costs		2,702			3,218			5,891			5,769			1,512			5,824			7,403			11,593
Contingent consideration		(6,884	)		—			(9,295	)		—			(2,309	)		—			(11,604	)		—
Loss on conversion of debt		—			4			—			4			—			1			—			6
Adjusted EBITDA	$	67,689		$	59,670		$	139,899		$	108,422		$	57,949		$	60,516		$	197,848		$	168,939

We have financed our operations primarily through revenues derived from product sales, the issuance of the 2019 Notes in July 2019 and the issuance of common stock in our December 2020, July 2019 and May 2019 public offerings. Our revenue for the foreseeable future will primarily be limited to our bioprocessing product revenue.

At ~~June~~September 30, 2022, we had cash and cash equivalents of ~~$596.5~~$573.4 million compared to cash and cash equivalents of $603.8 million at December 31, 2021.

On September 19, 2022, we entered into the Agreement with Daylight, giving us exclusive license and commercialization rights to use certain technology and intellectual property subject to conditions set forth in the Agreement. We agreed to pay Daylight (i) an initial, one-time, non-refundable, non-creditable upfront cash payment as of September 30, 2022 and (ii) quarterly royalty payments as defined in the Agreement.

During the ~~second~~third quarter of 2022, the closing price of ~~the Company’s~~our common stock exceeded 130% of the conversion price of the 2019 Notes for more than 20 trading days of the last 30 consecutive trading days of the quarter. As a result, the 2019 Notes are convertible at the option of the holders of the 2019 Notes during the ~~third~~fourth quarter of 2022, the quarter immediately following the quarter when the conditions are met, as stated in the terms of the 2019 Notes. These conditions have been met each quarter since the fourth quarter of 2020. As a result, ~~$24,000~~$25,000 in aggregate principal amount of the 2019 Notes have been converted by the noteholders since the issuance of the 2019 Notes, including ~~$9,000~~$14,000 during ~~the second quarter of~~ 2022. The conversions resulted in the issuance of a nominal number of shares of ~~the Company’s~~our common stock to the noteholders. ~~The Company continues~~We continue to classify the carrying value of the 2019 Notes as current liabilities on ~~the Company’s~~our consolidated balance sheet at ~~June~~September 30, 2022.

For the ~~six~~nine months ended ~~June~~September 30, 2022, our operating activities provided cash of ~~$68.8~~$110.2 million reflecting net income of ~~$96.8~~$137.2 million and non-cash charges totaling ~~$31.5~~$49.3 million primarily related to depreciation, amortization, contingent consideration adjustments, deferred income taxes and stock-based compensation charges. An increase in accounts receivable consumed ~~$8.4~~$8.6 million of cash and was primarily driven by the ~~35.4%~~27.0% year-to-date increase in revenues. Additionally, we had an increase in inventory manufactured of ~~$58.1~~$64.3 million to support expected increases in future revenue. ~~A decrease in accrued liabilities of $4.0~~Accounts payable decreased $10.1 million ~~relates~~due to the ~~payout~~timing of ~~employee bonuses and a decrease in our estimated income tax provision during the first half of 2022.~~payments to vendors. Offsetting these uses of cash was a ~~$6.3~~$4.1 million net increase in operating lease liabilities due to new operating leases entered into during 2022 and a $3.0 million increase in ~~accounts payable which correlates~~accrued liabilities due to the increase in ~~inventory and is also a result of the timing of payments to vendors and a decrease in prepaid expenses driven by a decrease in prepaid~~expected costs, including corporate income taxes. The remaining cash ~~provided by~~used in operating activities resulted from ~~favorable~~unfavorable changes in various other working capital accounts.

For the ~~six~~nine months ended ~~June~~September 30, 2021, our operating activities provided cash of ~~$46.9~~$69.4 million reflecting net income of ~~$65.7~~$99.2 million and non-cash charges totaling ~~$43.8~~$65.1 million primarily related to depreciation, amortization, inventory step-up amortization, deferred income taxes, non-cash interest expense, amortization of debt discount and issuance costs and stock-based compensation charges. An increase in accounts receivable consumed ~~$31.9~~$52.0 million of cash and was primarily driven by the ~~87.0%~~87.9% year-to-date increase in revenues. ~~Additionally, we had an~~An increase in inventory manufactured of ~~$42.8~~$61.6 million ~~to support~~supports expected increases in future revenue. The increases in accounts receivable and inventory manufactured are offset by an increase in accounts payable of ~~$8.3~~$9.0 million, which was primarily due to increased inventory purchases to support customer orders, an increase in accrued liabilities of ~~$4.5~~$10.1 million, which was due to an increase in accruals for expected costs, and to a decrease in deferred revenue related to products shipped during the first half of 2021. The remaining cash used in operating activities resulted from unfavorable changes in various other working capital accounts.

Our investing activities consumed ~~$54.4~~$111.9 million of cash during the ~~six~~nine months ended ~~June~~September 30, 2022, ~~and $26.2 million of cash during the six months ended June 30, 2021,~~ mainly due to $67.0 million of capital expenditures in 2022 as we continue to increase our manufacturing capacity worldwide. Of these expenditures, ~~$1.9 million and $2.2~~$2.6 million represented capitalized costs related to our internal-use software for the ~~six~~nine months ended ~~June~~September 30, 2022. In addition, in September 2022, the Company paid a one-time, non-refundable, non-creditable upfront payment to Daylight as required under a License Agreement for the commercialization and ~~2021, respectively.~~sale of Culpeo® QCL-IR Liquid Analyzer.

Our investing activities consumed $158.9 million of cash during the nine months ended September 30, 2021. We used $121.0 million in cash (net of cash received) for the Polymem Acquisition and the Avitide Acquisition, in the aggregate. Capital expenditures consumed $37.9 million as we continue to increase our manufacturing capacity worldwide. Of these expenditures, $2.9 million represented capitalized costs related to our internal-use software.

Our financing activities consumed ~~$14.3~~$13.1 million of cash for the ~~six~~nine months ended ~~June~~September 30, 2022, which included cash disbursed in relation to shares withheld to cover employee income tax due upon the vesting and release of restricted stock units of ~~$14.8~~$15.8 million. This was partially offset by proceeds received from stock option exercises during the period of ~~$0.5~~$2.8 million.

Cash provided by financing activities of ~~$0.9~~$0.7 million for the ~~six~~nine months ended ~~June~~September 30, 2021 included proceeds from stock option exercises during the ~~period.~~period offset by cash disbursed in relation to shares withheld to cover employee income taxes due upon the vesting and release of restricted stock units. Proceeds from stock option exercises during the nine months ended September 30, 2021 were $2.0 million, offset by $1.3 million of cash disbursed to pay tax obligations on the vesting of restricted stock units.

Working capital decreased by ~~$3.9~~$13.9 million to ~~$552.5~~$542.5 million at ~~June~~September 30, 2022 from $556.4 million at December 31, 2021 due to the various changes noted above.

Our future capital requirements will depend on many factors, including the following:

Absent acquisitions of additional products, product candidates or intellectual property, we believe our current cash balances are adequate to meet our cash needs for at least the next 24 months from the date of this filing. We expect operating expenses for the rest of the year to increase as we continue to expand our bioprocessing business. We expect to incur continued spending related to the development and expansion of our bioprocessing product lines and expansion of our commercial capabilities for the foreseeable future. Our future capital requirements may include, but are not limited to, purchases of property, plant and equipment, the acquisition of additional bioprocessing products and technologies to complement our existing manufacturing capabilities and continued investment in our intellectual property portfolio.

We plan to continue to invest in our bioprocessing business and in key R&D activities associated with the development of new bioprocessing products. We actively evaluate various strategic transactions on an ongoing basis, including acquiring products, technologies or businesses that would complement our existing portfolio. We continue to seek to acquire such potential assets that may offer us the best opportunity to create value for our shareholders. In order to acquire such assets, we may need to seek additional financing to fund these investments. If our available cash balances and anticipated cash flow from operations are insufficient to satisfy our liquidity requirements, including because of any such acquisition-related financing needs or lower demand for our products, we may seek to sell common or preferred equity or convertible debt securities, enter into a credit facility or another form of third-party funding, or seek other debt funding. The sale of equity and convertible debt securities may result in dilution to our shareholders, and those securities may have rights senior to those of our common shares. If we raise additional funds through the issuance of preferred stock, convertible debt securities or other debt financing, these securities or other debt could contain covenants that would restrict our operations. Any other third-party funding arrangement could require us to relinquish valuable rights. We may require additional capital beyond our currently anticipated amounts. Additional capital may not be available on reasonable terms, if at all.

At December 31, 2021, the Company had federal net operating loss carryforwards of $46.2 million, state net operating loss carryforwards of $4.0 million and foreign net operating loss carryforwards of $6.1 million. Federal net operating loss carryforwards of $19.1 million will expire at various dates through 2037. The other $27.1 million of the federal net operating loss carryforwards have unlimited carryforward periods. The total state net operating loss carryforwards will expire at various dates through 2041, while the foreign net operating loss carryforwards do not expire. We had business tax credits carryforwards of $2.7 million available to reduce future federal and state income taxes, if any. The business tax credits carryforwards will continue to expire at various dates through December 2041. Net operating loss carryforwards and available tax credits are subject to review and possible adjustment by the Internal Revenue Service, state and foreign jurisdictions and may be limited in the event of certain changes in the ownership interest of significant shareholders.

Our assets are primarily monetary, consisting of cash, cash equivalents and marketable securities. Because of their liquidity, these assets are not directly affected by inflation. Since we intend to retain and continue to use our equipment, furniture and fixtures and leasehold improvements, we believe that the incremental inflation related to replacement costs of such items will not materially affect our operations. However, the rate of inflation affects our expenses, such as those for employee compensation and contract services, which could increase our level of expenses and the rate at which we use our resources.

This Quarterly Report on Form 10-Q contains forward-looking statements which are made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”). The forward-looking statements in this Quarterly Report on Form 10-Q do not constitute guarantees of future performance. Investors are cautioned that statements in this Quarterly Report on Form 10-Q which are not strictly historical statements, including, without limitation, express or implied statements or guidance regarding current or future financial performance and position, potential impairment of future earnings, management’s strategy, plans and objectives for future

operations or acquisitions, product development and sales, product candidate research, development and regulatory approval, SG&A expenditures, intellectual property, development and manufacturing plans, availability of materials and product and adequacy of capital resources, our financing plans and the projected continued impact of, and response to, COVID-19 constitute forward-looking statements. These forward-looking statements are based on current expectations, estimates, forecasts and projections about the industry and markets in which the Company operates, and management’s beliefs and assumptions. The Company undertakes no obligation to publicly update or revise the statements in light of future developments. In addition, other written and oral statements that constitute forward-looking statements may be made by the Company or on the Company’s behalf. Words such as “expect,” “seek,” “anticipate,” “intend,” “plan,” “believe,” “could,” “estimate,” “may,” “target,” “project,” or variations of such words and similar expressions are intended to identify forward-looking statements. Such forward-looking statements are subject to a number of risks and uncertainties that could cause actual results to differ materially from those anticipated, including, without limitation, risks associated with the following: the impact of COVID-19 on demand for our products and on our business or financial results; the success of current and future collaborative or supply relationships, including our agreements with Cytiva, MilliporeSigma and Purolite Life Sciences, an Ecolab Inc. company; our ability to successfully grow our bioprocessing business, including as a result of acquisitions, commercialization or partnership opportunities, and our ability to develop and commercialize products; our ability to obtain required regulatory approvals; our compliance with all U.S. Food and Drug Administration regulations, our ability to obtain, maintain and protect intellectual property rights for our products; the risk of litigation regarding our patent and other intellectual property rights; the risk of litigation with collaborative partners; our manufacturing capabilities and our dependence on third-party manufacturers and value-added resellers; the effect of COVID-19, including mitigation efforts and economic effects, on our business operations and the operations of our customers and suppliers; our ability to hire and retain skilled personnel; the market acceptance of our products, reduced demand for our products that adversely impacts our future revenues, cash flows, results of operations and financial condition; our ability to integrate Polymem, Avitide and BioFlex businesses successfully into our business and achieve the expected benefits of the acquisitions; our ability to compete with larger, better financed life sciences companies; our history of losses and expectation of incurring losses; our ability to generate future revenues; our ability to successfully integrate our recently acquired businesses; our ability to raise additional capital to fund potential acquisitions; our volatile stock price; and the effects of our anti-takeover provisions. Further information on potential risk factors that could affect our financial results are included in the filings made by us from time to time with the SEC including under the sections entitled “Risk Factors” in our Form 10-K.

We have historically held investments in commercial paper, U.S. Government and agency securities as well as corporate bonds and other debt securities. As a result, we have been exposed to potential loss from market risks that may occur as a result of changes in interest rates, changes in credit quality of the issuer or otherwise. We do not have any such investments as of June 30, 2022. As a result, a hypothetical 100 basis point increase in interest rates would have no effect on our cash position as of June 30, 2022.

We generally place our marketable security investments in high quality credit instruments, as specified in our investment policy guidelines. We believe that the conservative nature of our investments mitigates our interest rate exposure, and our investment policy limits the amount of our credit exposure to any one issue, issuer (with the exception of U.S. agency obligations) and type of instrument. We do not expect any material losses from our marketable security investments and therefore believe that our potential interest rate exposure is limited. As a result, a hypothetical 100 basis point increase in interest rates would have no effect on our cash position as of September 30, 2022.

The reporting currency of the Company is U.S. dollars, and the functional currency of each of our foreign subsidiaries is its respective local currency. Our foreign currency exposures include the Swedish krona, Euro, British pound, Chinese yuan, Japanese yen, Singapore dollar, South Korean won and Indian rupee; of these, the primary foreign currency exposures are the Swedish krona, Euro and British pound. Exchange gains or losses resulting from the translation between the transactional currency and the functional currency are included in net income. Fluctuations in exchange rates may adversely affect our results of operations, financial position and cash flows. We currently do not seek to hedge this exposure to fluctuations in exchange rates.

The Company’s management, with the participation of the principal executive officer and the principal financial officer, has evaluated the effectiveness of the Company’s disclosure controls and procedures (as defined in Rules 13a-15(e) or 15d-15(e) under the Exchange Act) as of the end of the period covered by this report. Based on such evaluation, the principal executive officer and principal financial officer have concluded that, as of the end of such period, the Company’s disclosure controls and procedures were effective at the reasonable assurance level.

There have been no changes in our internal control over financial reporting identified in connection with the evaluation required by paragraph (d) of Exchange Act Rule 13a-15 or Rule 15d-15 that occurred in the three months ended ~~June~~September 30, 2022 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

From time to time, we may be subject to legal proceedings and claims in the ordinary course of business. We are not currently aware of any such proceedings or claims that we believe will have, individually or in the aggregate, a material adverse effect on our business, financial condition or results of operations.

The matters discussed in this Quarterly Report on Form 10-Q include forward-looking statements that involve risks or uncertainties. These statements are neither promises nor guarantees, but are based on various assumptions by management regarding future circumstances, over many of which Repligen has little or no control. A number of important risks and uncertainties, including those identified under the caption “Risk Factors” in Part I, Item 1A of our Form 10-K for the period ended December 31, 2021 and in subsequent filings, could cause our actual results to differ materially from those in the forward-looking statements. There are no material changes to the risk factors described in our Form 10-K for the period ended December 31, 2021.

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.



Delaware	04-2729386
(State or Other Jurisdiction of Incorporation or Organization)	(I.R.S. Employer Identification No.)

41 Seyon Street, Bldg. 1, Suite 100 Waltham, MA	02453
(Address of Principal Executive Offices)	(Zip Code)


Title of each class	Trading Symbol(s)	Name of each exchange on which registered

Common Stock, par value $0.01 per share	RGEN	The Nasdaq Global Select Market


		PAGE
PART I -	FINANCIAL INFORMATION

Item 1.	Financial Statements (interim periods unaudited)

	Consolidated Balance Sheets as of ~~June~~September 30, 2022 and December 31, 2021	3

	Consolidated Statements of Comprehensive Income for the Three and ~~Six~~Nine Months Ended ~~June~~September 30, 2022 and 2021	4

	Consolidated Statements of Stockholders’ Equity for the Three and ~~Six~~Nine Months Ended ~~June~~September 30, 2022 and 2021	5

	Consolidated Statements of Cash Flows for the ~~Six~~Nine Months Ended ~~June~~September 30, 2022 and 2021	67

	Notes to Unaudited Consolidated Financial Statements	78

Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	2728

Item 3.	Quantitative and Qualitative Disclosures About Market Risk	3740

Item 4.	Controls and Procedures	3840

PART II -	OTHER INFORMATION

Item 1.	Legal Proceedings	3941

Item 1A.	Risk Factors	3941

Item 2.	Unregistered Sales of Equity Securities and Use of Proceeds	3941

Item 3.	Defaults Upon Senior Securities	3941

Item 4.	Mine Safety Disclosures	3941

Item 5.	Other Information	3941

Item 6.	Exhibits	4042

Signatures		4143


	QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934


	TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934



Large accelerated filer		Accelerated filer	
Non-accelerated filer		Smaller reporting company	
Emerging growth company	


	Three Months Ended June 30, 2021
	Common Stock
	Number of Shares		Par Value		Additional Paid-In Capital		Accumulated Other Comprehensive Loss			Retained Earnings		Total Stockholders' Equity
Balance at March 31, 2021		54,899,245	$	549	$	1,467,942	$	(7,494	)	$	95,219	$	1,556,216
Net income		—		—		—		—			36,233		36,233
Exercise of stock options and vesting of stock units		70,236		1		351		—			—		352
Stock-based compensation expense		—		—		7,143		—			—		7,143
Translation adjustment		—		—		—		3,125			—		3,125
Balance at June 30, 2021		54,969,481	$	550	$	1,475,436	$	(4,369	)	$	131,452	$	1,603,069


	Three Months Ended September 30, 2021
	Common Stock
	Number of Shares			Par Value			Additional Paid-In Capital			Accumulated Other Comprehensive Loss			Retained Earnings		Total Stockholders' Equity
Balance at June 30, 2021		54,969,481		$	550		$	1,475,436		$	(4,369	)	$	131,452	$	1,603,069
Net income		—			—			—			—			33,498		33,498
Issuance of common stock for debt conversion		4			0			1			—			—		1
Exercise of stock options and vesting of stock units		48,746			0			1,131			—			—		1,131
Issuance of common stock pursuant to the acquisition of Avitide Inc.		271,096			3			77,573			—			—		77,576
Tax withholding on vesting of restricted stock units		(5,339	)		(0	)		(1,252	)		—			—		(1,252	)
Stock-based compensation expense		—			—			6,792			—			—		6,792
Translation adjustment		—			—			—			(5,550	)		—		(5,550	)
Balance at September 30, 2021		55,283,988		$	553		$	1,559,681		$	(9,919	)	$	164,950	$	1,715,265


Balance as of December 31, 2021	$	94,238
Contingent consideration earnouts		(9,295	)
Balance as of June 30, 2022	$	84,943


	Foreign
	Currency
	Translation
	Adjustment

Balance at December 31, 2021	$	(16,886	)
Other comprehensive loss		(~~20,205~~38,375	)
Balance at ~~June~~September 30, 2022	$	(~~37,091~~55,261	)


Exhibit Number		Document Description

3.1		Restated Certificate of Incorporation, dated June 30, 1992 and amended September 17, 1999 (filed as Exhibit 3.1 to Repligen Corporation’s Quarterly Report on Form 10-Q for the quarter ended September 30, 1999 and incorporated herein by reference).

3.2		Certificate of Amendment to the Certificate of Incorporation of Repligen Corporation, effective as of May 16, 2014 (filed as Exhibit 3.1 to Repligen Corporation’s Current Report on Form 8-K filed on May 19, 2014 and incorporated herein by reference).

3.3		Third Amended and Restated Bylaws (filed as Exhibit 3.1 to Repligen Corporation’s Current Report on Form 8-K filed on January 28, 2021 ~~and incorporated herein by reference).~~

~~10.1~~		Repligen Corporation Amended and Restated Severance and Change in Control Plan, effective as of May 26, 2022 (filed as Exhibit 10.1 to Repligen Corporation's Current Report on Form 8-K filed on June 1, 2022 and incorporated herein by reference).

~~10.2~~		Third Amended and Restated Employment Agreement, dated as of May26, 2022, by and between Repligen Corporation and Tony J. Hunt (filed as Exhibit 10.2 to Repligen Corporation's Current Report on Form 8-K filed on June 1, 2022 and incorporated herein by reference).

~~10.3~~		~~Repligen Corporation Amended and Restated Non-Employee Directors' Compensation Policy (filed as Exhibit 10.3 to Repligen Corporation's Current Report on Form 8-K filed on June 1, 2022~~ and incorporated herein by reference).

31.1 +		Rule 13a-14(a)/15d-14(a) Certification.

31.2 +		Rule 13a-14(a)/15d-14(a) Certification.

32.1 *		Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.

101.INS+		XBRL Instance Document – the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document.

101.SCH+		Inline XBRL Taxonomy Extension Schema Document.

101.CAL+		Inline XBRL Taxonomy Extension Calculation Linkbase Document.

101.DEF+		Inline XBRL Taxonomy Extension Definition Linkbase Document.

101.LAB+		Inline XBRL Taxonomy Extension Label Linkbase Document.

101.PRE+		Inline XBRL Taxonomy Extension Presentation Linkbase Document.

104+		Cover Page Interactive Data File (formatted as Inline XBRL with applicable taxonomy extension information contained in Exhibits 101.*).



	REPLIGEN CORPORATION

Date: ~~August 2,~~November 1, 2022	By:	/S/ TONY J. HUNT
		Tony J. Hunt
		President and Chief Executive Officer
		(Principal executive officer)
		Repligen Corporation

Date: ~~August 2,~~November 1, 2022	By:	/S/ JON SNODGRES
		Jon Snodgres
		Chief Financial Officer
		(Principal financial officer)
		Repligen Corporation