Table of Contents


UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 10-Q
(Mark One)
☑
þ
QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
SECURITIES EXCHANGE ACT OF 1934
For the Quarterly Period Ended September 30, 2017March 31, 2024
or
☐
q
TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
SECURITIES EXCHANGE ACT OF 1934
For the Transition Period from _____________ to _____________
Commission File Number:  000-30111
Lexicon Pharmaceuticals, Inc.
(Exact Name of Registrant as Specified in its Charter)
Delaware76-0474169
Delaware76-0474169
(State or Other Jurisdiction of

Incorporation or Organization)
(I.R.S. Employer

Identification Number)

88002445 Technology Forest PlaceBlvd.
11th Floor
The Woodlands, Texas 77381
(Address of Principal Executive Offices and Zip Code)
(281) 863-3000
(Registrant’s Telephone Number, Including Area Code)
Securities registered pursuant to Section 12(b) of the Act:
Title of each classTrading Symbol(s)Name of each exchange on which registered
Common Stock, par value $0.001LXRXThe Nasdaq Global Select Market
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports) and (2) has been subject to such filing requirements for the past 90 days.
Yes☑No
YesþNo
Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).
Yes☑No
YesþNo
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company.  See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
Large accelerated filer     Accelerated filer þNon-accelerated filer   ☑       
Smaller reporting company    ☑      Emerging growth company
If an emerging growth company, indicate by check mark if the registration has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. q☐
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).
Yes☐No
YesNoþ☑


As of November 6, 2017, 105,587,794April 29, 2024, 246,236,753 shares of the registrant’s common stock, par value $0.001 per share, were outstanding.



Lexicon Pharmaceuticals, Inc.
 
Table of Contents
Page
32
3
Item 1.
3
Condensed Consolidated Balance Sheets - September 30, 2017March 31, 2024 (unaudited) and December 31, 2016
2023
3
Condensed Consolidated Statements of Comprehensive Loss (unaudited) - Three and Nine Months Ended September 30, 2017March 31, 2024 and 2016
2023
4
Condensed Consolidated Statements of Stockholders’ Equity (unaudited) - NineThree Months Ended September 30, 2017March 31, 2024 and 2016
2023
5
Condensed Consolidated Statements of Cash Flows (unaudited) - NineThree Months Ended September 30, 2017March 31, 2024 and 2016
2023
6
Notes to Condensed Consolidated Financial Statements (unaudited)
7
Item 2.
2114
Item 3.
2618
Item 4.
2618
2620
Item 1.
2720
Item 1A.
2720
Item 6.2.
22
Item 5.
23
Item 6.
24
25


The Lexicon name and logo and XERMELO®INPEFA® are registered trademarks of Lexicon Pharmaceuticals, Inc.
 
——————


Factors Affecting Forward Looking Statements
This quarterly report on Form 10-Q contains forward-looking statements. These statements relate to future events or our future financial performance. We have attempted to identify forward-looking statements by terminology including “anticipate,” “believe,” “can,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “should” or “will” or the negative of these terms or other comparable terminology. These statements are only predictions and involve known and unknown risks, uncertainties and other factors, including the risks outlined under “Part II, Item 1A. - Risk Factors” and in our annual report on Form 10-K for the year ended December 31, 2016,2023, that may cause our or our industry’s actual results, levels of activity, performance or achievements to be materially different from any future results, levels or activity, performance or achievements expressed or implied by these forward-looking statements.
Although we believe that the expectations reflected in the forward-looking statements are reasonable, future results, levels of activity, performance or achievements may vary materially from our expectations. We are not undertaking any duty to update any of the forward-looking statements after the date of this quarterly report on Form 10-Q to conform these statements to actual results, unless required by law.





2

Part I – Financial Information
 
Item 1.  Financial Statements
 
Lexicon Pharmaceuticals, Inc.


Condensed Consolidated Balance Sheets
(In thousands, except par value)value and share amounts)
 As of March 31,As of December 31,
 20242023
Assets(unaudited) 
Current assets:  
Cash and cash equivalents$96,494 $22,465 
Short-term investments259,104 147,561 
Accounts receivable, net1,526 1,010 
Inventory514 381 
Prepaid expenses and other current assets7,009 5,130 
Total current assets364,647 176,547 
Property and equipment, net of accumulated depreciation and amortization of $4,682 and $4,538, respectively1,843 1,987 
Goodwill44,543 44,543 
Operating lease right-of-use-assets5,358 5,524 
Other assets828 828 
Total assets$417,219 $229,429 
Liabilities and Stockholders’ Equity  
Current liabilities:  
Accounts payable$8,067 $14,389 
Accrued liabilities15,332 17,157 
Total current liabilities23,399 31,546 
Long-term debt, net99,874 99,508 
Long-term operating lease liabilities5,079 5,265 
Total liabilities128,352 136,319 
Commitments and contingencies (Note 6)
Stockholders’ Equity:  
Preferred stock, $0.01 par value; 5,000,000 shares authorized
Series A Convertible preferred stock, 2,304,147 and no shares issued, respectively23 — 
Common stock, $0.001 par value; 300,000,000 shares authorized; 247,764,761 and 245,792,668 shares issued, respectively248 245 
Additional paid-in capital2,108,497 1,862,558 
Accumulated deficit(1,815,236)(1,766,839)
Accumulated other comprehensive income/(loss)(50)31 
Treasury stock, at cost, 1,528,008 and 867,973 shares, respectively(4,615)(2,885)
Total stockholders’ equity288,867 93,110 
Total liabilities and stockholders’ equity$417,219 $229,429 

  As of September 30, As of December 31,
  2017 2016
Assets (unaudited)  
Current assets:    
Cash and cash equivalents $83,293
 $46,600
Short-term investments 113,524
 299,904
Accounts receivable, net of allowances of $4 10,597
 7,492
Inventory 2,149
 —
Prepaid expenses and other current assets 4,458
 3,878
Total current assets 214,021
 357,874
Property and equipment, net of accumulated depreciation and amortization of $58,794 and $59,875, respectively 18,167
 19,390
Goodwill 44,543
 44,543
Other intangible assets, net of accumulated amortization of $1,030 and $0, respectively 52,327
 53,357
Other assets 429
 461
Total assets $329,487
 $475,625
Liabilities and Equity    
Current liabilities:    
Accounts payable $52,628
 $52,877
Accrued liabilities 12,729
 32,114
Current portion of deferred revenue 48,738
 63,372
Current portion of long-term debt, net of deferred issuance costs 14,633
 16,280
Total current liabilities 128,728
 164,643
Deferred revenue, net of current portion 26,545
 48,934
Long-term debt, net of deferred issuance costs 85,512
 85,167
Deferred tax liabilities 10,023
 18,675
Other long-term liabilities 303
 805
Total liabilities 251,111
 318,224
Commitments and contingencies 
 
Equity:    
Preferred stock, $.01 par value; 5,000 shares authorized; no shares issued and outstanding —
 —
Common stock, $.001 par value; 225,000 shares authorized; 105,710 and 104,582 shares issued, respectively 106
 105
Additional paid-in capital 1,433,263
 1,411,222
Accumulated deficit (1,353,026) (1,250,363)
Accumulated other comprehensive loss (63) (195)
Treasury stock, at cost, 122 and 306 shares, respectively (1,904) (3,368)
Total equity 78,376
 157,401
Total liabilities and equity $329,487
 $475,625

The accompanying notes are an integral part of these condensed consolidated financial statements.



3

Lexicon Pharmaceuticals, Inc.


Condensed Consolidated Statements of Comprehensive Loss
(In thousands, except per share amounts)
(Unaudited)

 Three Months Ended March 31,
 20242023
Revenues:
Net product revenue$1,093 $— 
Royalties and other revenue37 24 
Total revenues1,130 24 
Operating expenses:
Cost of sales31 — 
Research and development, including stock-based compensation of $1,594 and $1,203, respectively14,372 12,026 
Selling, general and administrative, including stock-based compensation of $2,708 and $2,212, respectively32,060 19,140 
Total operating expenses46,463 31,166 
Loss from operations(45,333)(31,142)
Interest and other expense (4,948)(1,821)
Interest income and other, net1,884 1,029 
Net loss$(48,397)$(31,934)
Net loss per common share, basic and diluted$(0.20)$(0.17)
Shares used in computing net loss per common share, basic and diluted245,390 189,014 
Other comprehensive loss:
Unrealized (loss) gain on investments(81)265 
Comprehensive loss$(48,478)$(31,669)
  Three Months Ended September 30, Nine Months Ended September 30,
  2017 2016 2017 2016
Revenues:        
Net product revenue $5,830
 $—
 $10,443
 $—
Collaborative agreements 21,112
 27,686
 46,781
 60,181
Subscription and license fees  —
 31
 64
 119
Total revenues 26,942
 27,717
 57,288
 60,300
Operating expenses:        
Cost of sales (including finite-lived intangible asset amortization) 599
 —
 1,361
 —
Research and development, including stock-based compensation of $1,345, $1,051, $3,698 and $3,013, respectively 39,137
 52,533
 109,653
 137,751
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability —
 (2,146) 2,101
 (703)
Selling, general and administrative, including stock-based compensation of $1,235, $879, $3,516 and $2,709, respectively 16,724
 12,263
 50,069
 29,077
Total operating expenses 56,460
 62,650
 163,184
 166,125
Loss from operations  (29,518) (34,933) (105,896) (105,825)
Interest expense  (1,619) (1,646) (4,821) (4,933)
Interest and other income, net 415
 564
 1,393
 1,748
Net loss before taxes (30,722) (36,015) (109,324) (109,010)
Income tax benefit —
 —
 8,652
 —
Net loss $(30,722) $(36,015) $(100,672) $(109,010)
Net loss per common share, basic and diluted $(0.29) $(0.35) $(0.96) $(1.05)
Shares used in computing net loss per common share, basic and diluted   105,582
 103,885
 105,119
 103,799
         
Other comprehensive loss:        
Unrealized gain (loss) on investments 151
 (258) 132
 297
Comprehensive loss $(30,571) $(36,273) $(100,540) $(108,713)



The accompanying notes are an integral part of these condensed consolidated financial statements.



4

Lexicon Pharmaceuticals, Inc.


Condensed Consolidated Statements of Stockholders’ Equity
(In thousands)
(Unaudited)

Common StockPreferred StockAdditionalAccumulated Other
SharesPar ValueSharesPar ValuePaid-In CapitalAccumulated DeficitComprehensive Gain (Loss)Treasury StockTotal
Balance at December 31, 2022189,214 $189 — $— $1,709,144 $(1,589,720)$(428)$(2,061)$117,124 
Stock-based compensation— — — — 3,415 — — — 3,415 
Issuance of common stock under Equity Incentive Plans1,216 1 — — (1)— — — — 
Repurchase of common stock— — — — — — — (824)(824)
Net loss— — — — — (31,934)— — (31,934)
Unrealized gain (loss) on investments— — — — — — 265 — 265 
Balance at March 31, 2023190,430 $190 — $— $1,712,558 $(1,621,654)$(163)$(2,885)$88,046 


Common StockPreferred StockAdditionalAccumulated Other
SharesPar ValueSharesPar ValuePaid-In CapitalAccumulated DeficitComprehensive Gain (Loss)Treasury StockTotal
Balance at December 31, 2023245,793 $245 $— $— $1,862,558 $(1,766,839)$31 $(2,885)$93,110 
Stock-based compensation— — — — 4,302 — — — 4,302 
Issuance of preferred stock, net of fees— — 2,304 23 241,552 — — — 241,575 
Issuance of common stock under Equity Incentive Plans1,972 3 — — 85 — — — 88 
Repurchase of common stock— — — — — — — (1,730)(1,730)
Net loss— — — — — (48,397)— — (48,397)
Unrealized gain (loss) on investments— — — — — — (81)— (81)
Balance at March 31, 2024247,765 $248 2,304 $23 $2,108,497 $(1,815,236)$(50)$(4,615)$288,867 
  Common Stock Additional   Accumulated Other    
  Shares Par Value Paid-In Capital Accumulated Deficit Comprehensive Gain (Loss) Treasury Stock Total
Balance at December 31, 2015 103,860
 $104
 $1,397,646
 $(1,108,934) $(219) $(2,747) $285,850
Stock-based compensation —
 —
 5,722
 —
 —
 —
 5,722
Issuance of common stock under Equity Incentive Plans 463
 —
 2,943
 —
 —
 —
 2,943
Repurchase of common stock —
 —
 —
 —
 —
 (621) (621)
Net loss —
 —
 —
 (109,010) —
 —
 (109,010)
Unrealized gain on investments —
 —
 —
 —
 297
 —
 297
Balance at September 30, 2016 104,323
 $104
 $1,406,311
 $(1,217,944) $78
 $(3,368) $185,181
               
Balance at December 31, 2016 104,582
 $105
 $1,411,222
 $(1,250,363) $(195) $(3,368) $157,401
Cumulative effect of change in accounting principle —
 —
 1,991
 (1,991) —
 —
 —
Issuance of common stock to designees of Symphony Icon Holdings LLC 660
 —
 10,499
 —
 —
 —
 10,499
Stock-based compensation —
 —
 7,214
 —
 —
 —
 7,214
Issuance of common stock under Equity Incentive Plans 468
 1
 5,480
 —
 —
 —
 5,481
Issuance of treasury stock —
 —
 (3,143) —
 —
 3,143
 —
Repurchase of common stock —
 —
 —
 —
 —
 (1,679) (1,679)
Net loss —
 —
 —
 (100,672) —
 —
 (100,672)
Unrealized gain on investments —
 —
 —
 —
 132
 —
 132
Balance at September 30, 2017 105,710
 $106
 $1,433,263
 $(1,353,026) $(63) $(1,904) $78,376



The accompanying notes are an integral part of these condensed consolidated financial statements.

5


Lexicon Pharmaceuticals, Inc.
 
Condensed Consolidated Statements of Cash Flows
(In thousands)
(Unaudited)
Three Months Ended March 31,
20242023
Cash flows from operating activities:
Net loss$(48,397)$(31,934)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization144 112 
Stock-based compensation4,302 3,415 
Amortization of debt-related costs517 265 
Other non-cash adjustments(226)— 
Changes in operating assets and liabilities:
Increase in accounts receivable(516)(234)
Increase in inventories(133)— 
Increase in prepaid expenses and other current assets(1,879)(867)
Decrease in other long-term assets166 400 
Decrease in accounts payable and other liabilities(9,108)(2,770)
Net cash used in operating activities(55,130)(31,613)
Cash flows from investing activities:
Purchases of property and equipment— (248)
Purchases of investments(183,224)(28,864)
Maturities of investments73,000 41,205 
Net cash (used in) provided by investing activities(110,224)12,093 
Cash flows from financing activities:
Proceeds from issuance of common stock for equity incentive plans88 — 
Proceeds from issuance of preferred stock, net of fees241,425 — 
Repurchase of common stock for equity incentive plans(1,730)(824)
Other(400)— 
Net cash provided by (used in) financing activities239,383 (824)
Net increase (decrease) in cash and cash equivalents74,029 (20,344)
Cash and cash equivalents at beginning of period22,465 46,345 
Cash and cash equivalents at end of period$96,494 $26,001 
Supplemental disclosure of cash flow information:
Cash paid for interest$3,257 $1,556 
Supplemental disclosure of non-cash investing and financing activities:
Accrued financing costs$150 $— 
  Nine Months Ended September 30,
  2017 2016
Cash flows from operating activities:    
Net loss $(100,672) $(109,010)
Adjustments to reconcile consolidated net loss to net cash used in operating activities:    
Depreciation and amortization 2,475
 1,548
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability 2,101
 (703)
Stock-based compensation 7,214
 5,722
Amortization of debt issuance costs 412
 389
Deferred tax benefit (8,652) —
Loss on disposal of property and equipment 2
 12
Changes in operating assets and liabilities:    
(Increase) decrease in accounts receivable (3,105) 173
(Increase) in inventory (2,149) —
(Increase) decrease in prepaid expenses and other current assets (580) 7,694
(Increase) decrease in other assets 32
 (25)
Increase (decrease) in accounts payable and other liabilities (11,738) 18,705
Decrease in deferred revenue (37,023) (51,342)
Net cash used in operating activities (151,683) (126,837)
Cash flows from investing activities:    
Purchases of property and equipment (224) (83)
Purchases of investments (59,237) (336,649)
Maturities of investments 245,749
 298,525
Net cash provided by (used in) investing activities 186,288
 (38,207)
Cash flows from financing activities:    
Proceeds from issuance of common stock 5,481
 2,943
Repurchase of common stock (1,679) (621)
Repayment of debt borrowings (1,714) (1,495)
Net cash provided by financing activities 2,088
 827
Net increase (decrease) in cash and cash equivalents 36,693
 (164,217)
Cash and cash equivalents at beginning of period 46,600
 202,989
Cash and cash equivalents at end of period $83,293
 $38,772
     
Supplemental disclosure of cash flow information:    
Cash paid for interest $3,272
 $3,406
     
Supplemental disclosure of non-cash investing and financing activities:    
Common stock issued in satisfaction of Symphony Icon payment obligation $10,499
 $—
Unrealized gain on investments $132
 $297


The accompanying notes are an integral part of these condensed consolidated financial statements.



6



Lexicon Pharmaceuticals, Inc.


Notes to Condensed Consolidated Financial Statements
(Unaudited)


1.Summary of Significant Accounting Policies
 
Basis of Presentation:Presentation. The accompanying unaudited condensed consolidated financial statements of Lexicon Pharmaceuticals, Inc. (“Lexicon” or the “Company”) include the accounts of Lexicon and its wholly-owned subsidiaries. Intercompany transactions and balances are eliminated in consolidation. These unaudited condensed consolidated financial statements have been prepared in accordance with generally accepted accounting principles for interim financial information and pursuant to the rules and regulations of the Securities and Exchange Commission (“SEC”). Accordingly, they do not include all of the information and footnotes required by generally accepted accounting principles for complete financial statements.

In the opinion of management, all adjustments (consisting of normal recurring adjustments) considered necessary for a fair presentation have been included. Operating results for the nine-monththree month period ended September 30, 2017March 31, 2024 are not necessarily indicative of the results that may be expected for the year ended December 31, 2017.
The accompanying consolidated financial statements include the accounts of Lexicon and its wholly-owned subsidiaries. Intercompany transactions and balances are eliminated in consolidation.
2024. For further information, refer to the financial statements and footnotes thereto included in Lexicon’s annual report on Form 10-K for the year ended December 31, 2016,2023, as filed with the SEC. 

Use of Estimates:Estimates. The preparation of financial statements in conformity with U. S.U.S. generally accepted accounting principles (“GAAP”) requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the period. Actual results could differ from those estimates.
 
Significant Accounting Policies.There have been no significant changes to our summary of significant policies discussed in our annual report on Form 10-K for the year ended December 31, 2023.

Recent Accounting Pronouncements Issued But Not Yet Adopted. In November 2023, the FASB issued ASU 2023-07, Segment Reporting (Topic 280) – Improvements to Reportable Segment Disclosures, which is effective retrospectively for fiscal years beginning after December 15, 2023 and interim periods within fiscal years beginning after December 15, 2024. In December 2023, the FASB issued ASU 2023-09, Income Taxes (Topic 740) – Improvements to Income Tax Disclosures, which is effective prospectively for annual periods beginning after December 15, 2024. Early adoption is permitted for both standards. We do not expect these accounting pronouncements to have a material impact on our financial statements.

7

2.           Cash and Cash Equivalents and Short-Term Investments: Lexicon considers all highly-liquidInvestments

The fair value of cash and cash equivalents and investments with original maturities of three months or less to be cash equivalents.  As of September 30, 2017held at March 31, 2024 and December 31, 2016, short-term2023 are as follows:
 As of March 31, 2024
 Amortized CostGross Unrealized GainsGross Unrealized LossesEstimated Fair Value
 (in thousands)
Cash and cash equivalents$96,494 $— $— $96,494 
Securities maturing within one year:    
U.S. treasury securities245,145 9 (56)245,098 
Corporate debt securities14,008 3 (5)14,006 
Total short-term investments$259,153 $12 $(61)$259,104 
Total cash and cash equivalents and investments$355,647 $12 $(61)$355,598 
 As of December 31, 2023
 Amortized CostGross Unrealized GainsGross Unrealized LossesEstimated Fair Value
  (in thousands) 
Cash and cash equivalents$22,465 $— $— $22,465 
Securities maturing within one year:    
U.S. treasury securities141,577 31 (12)141,596 
Corporate debt securities5,954 11 — 5,965 
Total short-term investments$147,531 $42 $(12)$147,561 
Total cash and cash equivalents and investments$169,996 $42 $(12)$170,026 

As of March 31, 2024 and December 31, 2023, our investments consistin an unrealized loss position had an estimated fair value of $216.0 million and $58.5 million, respectively. There were no realized gains or losses during either of the three month periods ended March 31, 2024 and 2023.
3.            Fair Value Measurements
The Company uses various inputs in determining the fair value of its investments and measures these assets on a recurring basis. Assets and liabilities recorded at fair value in the condensed consolidated balance sheets are categorized by the level of objectivity associated with the inputs used to measure their fair value. The following levels are directly related to the amount of subjectivity associated with the inputs to fair valuation of these assets and liabilities:

•Level 1 - quoted prices in active markets for identical assets, which include U.S. treasury bills andsecurities
•Level 2 - other significant observable inputs (including quoted prices for similar investments, market corroborated inputs, etc.), which includes corporate debt securities
•Level 3 - significant unobservable inputs
8

The inputs or methodology used for valuing securities are not necessarily an indication of the credit risk associated with investing in those securities. The following tables provide the fair value measurements of applicable Company assets that are measured at fair value on a recurring basis according to the fair value levels defined above as of March 31, 2024 and December 31, 2023. There were no transfers between Level 1 and Level 2 during the periods presented.
 Assets at Fair Value as of March 31, 2024
 Level 1Level 2Level 3Total
(in thousands)
Cash and cash equivalents$96,494 $— $— $96,494 
Short-term investments245,098 14,006 — 259,104 
Total cash and cash equivalents and investments$341,592 $14,006 $— $355,598 
 Assets at Fair Value as of December 31, 2023
 Level 1Level 2Level 3Total
 (in thousands)
Cash and cash equivalents$22,465 $— $— $22,465 
Short-term investments141,596 5,965 — 147,561 
Total cash and cash equivalents and investments$164,061 $5,965 $— $170,026 

The carrying amount of cash and cash equivalents, prepaid expenses and other assets, accounts payable and accrued expenses are generally considered to be representative of their respective fair values because of the short-term nature of those instruments. The fair value of the Oxford Term Loans (see Note 5) is determined under Level 2 in the fair value hierarchy and approximates carrying value as the loans bear interest at a rate that approximates prevailing market rates for instruments with similar characteristics.

4. Supplemental Financial Information

The following tables show the Company’s short-term investmentsadditional balance sheet information as of March 31, 2024 and December 31, 2023:

As of March 31,As of December 31,
20242023
(in thousands)
Inventories:
Raw materials$— $— 
Work-in-progress84 100 
Finished goods430 281 
Inventory$514 $381 

As of March 31,As of December 31,
20242023
(in thousands)
Accrued Liabilities:
Accrued research and development services$3,688 $3,705 
Accrued compensation and benefits6,493 9,591 
Short-term lease liability1,291 1,291 
Other3,860 2,570 
Total accrued liabilities$15,332 $17,157 

9

5.          Debt Obligations
Oxford Term Loans Overview. Lexicon and one of its subsidiaries entered into a loan and security agreement with Oxford Finance LLC (“Oxford”) in March 2022 (as subsequently amended) that provides up to $150 million in borrowing capacity (the “Oxford Term Loans”).
The Oxford Term Loans are available in five tranches, each maturing in March 2027. The first two $25 million tranches totaling $50 million were funded in 2022 and the third $50 million tranche was funded in June 2023. The fourth $25 million tranche will be available for draw at Lexicon’s option upon the achievement of specified INPEFA net sales and until April 15, 2025. An unused fee will be due in the event Lexicon does not draw the full amount when available under the fourth tranche. The fifth $25 million tranche is available for draw at Lexicon’s option, subject to Oxford’s consent, at any time prior to the expiration of the interest-only period in March 2025 as described below.
As of March 31, 2024, the carrying value of the Oxford Term Loans on the condensed consolidated balance sheet was $99.9 million, reflecting an unamortized discount of $6.1 million to the face value of long-term debt related to debt issuance costs, the final payment exit fee, and the warrant fair value described below, which are being amortized into interest and other expense throughout the life of the term loan using the effective interest rate method. A final payment exit fee of $6.0 million equal to 6% of the amount funded under the Oxford Term Loans is due upon prepayment or maturity.
Oxford Warrants. Concurrent with the funding of each of the first three tranches, Lexicon granted Oxford warrants to purchase 420,673 shares of Lexicon’s common stock at an exercise price of $2.08 per share, 224,128 shares of Lexicon’s common stock at an exercise price of $1.95 per share and 183,824 shares of Lexicon’s common stock at an exercise price of $2.38 per share, respectively. Subject to and upon funding of the fourth tranche, Lexicon will grant Oxford a warrant to purchase shares of its common stock having a value equal to 1.75% of such tranche, as determined by reference to a 10-day average closing price of the shares, and having an exercise price equal to such average closing price. All warrants are exercisable for five years from their respective grant dates and feature a net cashless exercise provision. The Company allocated the proceeds from each term loan tranche to the corresponding warrant using the relative fair value method and used the Black-Scholes model to calculate the fair value of the warrants. These warrants reduced the carrying value of long-term debt and are classified as available-for-sale securitiesequity instruments in additional paid-in capital on the condensed consolidated balance sheet.
Interest and Principal Payments. Monthly interest-only payments are carried at fair value,due during an initial 36-month period from the original March 2022 borrowing date. The interest-only period will be followed by an amortization period extending through the maturity date. Payments of $34.8 million, $52.2 million, and $19.0 million, including debt principal and final exit fee payments, will be due during the fiscal years ended December 31, 2025, December 31, 2026 and December 31, 2027, respectively, with respect to all borrowed loan tranches as of March 31, 2024. Any prepayment of the Oxford Term Loans is subject to prepayment fees of up to 3% which decline over the three years following the funding date of each loan tranche. The Company has classified its debt as long-term based on quoted market pricesits intent and ability to refinance with the recent equity financing (see Note 8) if the Company is unable to meet the financial covenants within one year.
Prior to June 2023 the Oxford Term Loans bore interest at a floating rate equal to the 30-day U.S. Dollar LIBOR plus 7.90%, but not less than 8.01%, subject to additional interest if an event of default occurs and is continuing. Following the securities.  The Company views its available-for-sale securities as available for use in current operations regardless ofJune 2023 amendment to the stated maturity date ofloan and security agreement, the security.  Unrealized gains and losses on such securities are reported as a separate component of stockholders’ equity.  Net realized gains and losses,floating interest and dividends are included in interest income.  The cost of securities soldrate is currently based on the specific identification method.sum of (a) the 1-month CME Term Secured Overnight Financing Rate (SOFR), (b) 0.10%, and (c) 7.90% for the first and second tranches and 7.00% for the third and fourth tranches. As of March 31, 2024, the weighted average interest rate of the Oxford Term Loans was 12.9%. During the three months ended March 31, 2024, the Company recognized interest expense of $3.8 million, including $0.5 million in amortization of discount and related debt issuance costs.

Restrictive Provisions/Covenants. If an event of default occurs and is continuing, Oxford may declare all amounts outstanding under the loan and security agreement to be immediately due and payable. Additionally, Lexicon may prepay the Oxford Term Loans in whole at its option at any time.
Lexicon’s obligations under the Oxford Term Loans are secured by a first lien security interest in all of the assets of the Company and its subsidiaries. The loan and security agreement contains certain customary representations and warranties, affirmative and negative covenants and events of default applicable to Lexicon and its subsidiaries. The loan and security agreement includes a financial covenant which requires Lexicon to maintain a minimum cash and investments balance of $10 million until the achievement of specified INPEFA net sales. Upon funding of the fourth tranche, the minimum cash and investments balance will increase to $25 million. The loan and security agreement also includes a separate financial covenant
relating to net sales of INPEFA. In March 2024, this covenant was further amended and will be effective as of June 30, 2024. In addition to the financial covenants, additional covenants include those restricting dispositions, fundamental changes to its
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business, mergers or acquisitions, indebtedness, encumbrances, distributions, investments, transactions with affiliates and subordinated debt. The Company was in compliance with its debt covenants as of March 31, 2024.

6.            Commitments and Contingencies
 
Accounts Receivable:Operating Lease Obligations.  Lexicon’s operating leases include leases of office space in The Woodlands, Texas and Bridgewater, New Jersey and will expire in August 2025 and January 2034, respectively. Operating lease right-of-use assets and associated lease liabilities are recorded in the condensed consolidated balance sheet at the lease commencement date based on the present value of future lease payments to be made over the expected lease term. As the implicit rate is not determinable in its leases, Lexicon records trade accounts receivableuses its incremental borrowing rate based on the information available at the commencement date to determine the present value of lease payments. Lexicon does not apply this accounting to those leases with terms of twelve months or less.

As of March 31, 2024 and December 31, 2023, the right-of-use assets for the office space leases of $5.4 million and $5.5 million, respectively, are separately included in operating lease right-of-use-assets in the condensed consolidated balance sheet. Current liabilities relating to the leases were included in accrued liabilities in the condensed consolidated balance sheet (as further described in Note 4) and long-term operating lease liabilities are separately included in the condensed consolidated balance sheet.

During the three months ended March 31, 2024 and 2023, the Company incurred lease expense of $0.4 million. During the three months ended March 31, 2024 and 2023, the Company made cash payments for lease liabilities of $0.3 million and $0.1 million, respectively. As of March 31, 2024 and December 31, 2023, the weighted-average remaining lease terms were 8.9 years and 9 years, respectively, with weighted-average discount rates of 9.6%.

The following table reconciles the undiscounted cash flows of the operating lease liability to the recorded lease liability at March 31, 2024:

 (in thousands)
2024$1,036 
20251,220 
2026865 
2027881 
2028898 
Thereafter4,746 
Total undiscounted operating lease liability9,646 
Less: amount of lease payments representing interest(3,276)
Present value of future lease payments6,370 
Less: short-term operating lease liability(1,291)
Long-term operating lease liability$5,079 

Legal Proceedings.  Lexicon is from time to time party to claims and legal proceedings that arise in the normal course of its business related to the sale of productsand that it believes will not have, individually or services.   The allowance for doubtful accounts takes into consideration such factors as historical write-offs, the economic climate and other factors that could affect collectibility.  Write-offs are evaluated on a case by case basis.

Inventory: Inventories are determined at the lower of cost or market value with cost determined under the specific identification method and may consist of raw materials, work in process and finished goods. The Company began capitalizing inventory during the nine months ended September 30, 2017 once the U.S. Food and Drug Administration (“FDA”) approved XERMELO® (telotristat ethyl) as the related costs were expected to be recoverable through the commercialization of the product. Costs incurred prior to approval of XERMELO were recorded as research and development expense in the consolidated statementsaggregate, a material adverse effect on its results of comprehensive loss. As a result, cost of sales for approximately the next two years will reflect a lower average per unit cost of materials. Inventory consisted of the following as of September 30, 2017 (in thousands):operations, financial condition or liquidity.

7.Equity Incentive Awards
Raw materials $734
Work-in-process 41
Finished goods 1,374
Total inventory $2,149


Concentration of Credit Risk: Lexicon’s cash equivalents, investments and accounts receivable represent potential concentrations of credit risk. The Company attempts to minimize potential concentrations of risk in cash equivalents and investments by placing investments in high-quality financial instruments. The Company’s accounts receivable are unsecured and are concentrated in pharmaceutical and biotechnology companies located in Europe and the United States.Stock-Based Compensation.  The Company has not experienced any significant credit losses to date.  
Segment Information and Significant Customers: Lexicon operates in one business segment, which primarily focuses on the discovery, development and commercialization of pharmaceutical products for the treatment of human disease. Substantially all of the Company’s revenues have been derived from drug discovery alliances, target validation collaborations for the development and, in some cases, analysis of the physiological effects of genes altered in knockout mice, technology licenses, subscriptions to its databases, government grants and contracts, compound library sales and product sales.
Property and Equipment: Property and equipmentstockholder-approved equity incentive plans that is held and used is carried at cost and depreciated using the straight-line method over the estimated useful life of the assets which ranges from three to 40 years.  Maintenance, repairs and minor replacements are charged to expense as incurred.  Leasehold improvements are amortized over the shorter of the estimated useful life or the remaining lease term.  Significant renewals and betterments are capitalized.

Other Intangible Assets: Other intangible assets, net consist of in-process research and development acquired in business combinations, which are reported at fair value, less accumulated amortization. Intangible assets with finite lives are amortized using the straight-line method over their estimated useful lives. During the nine months ended September 30, 2017, intangible assets relating to XERMELO of $24.7 million were reclassified from indefinite-lived to finite-lived assets once the FDA approved XERMELO. The Company recorded $0.4 million and $1.0 million in amortization expense related to this asset, which is recorded as cost of sales in the accompanying consolidated statements of comprehensive loss for the three and nine months ended September 30, 2017, respectively.

During the nine months ended September 30, 2017, the Company’s valuation allowance for its deferred tax assets decreased by $8.7 million due to the reclassification of intangible assets relating to XERMELO from indefinite-lived to finite-lived assets, which resulted in the related deferred tax liability now being considered a source of taxable income. The Company recorded a $8.7 million deferred tax benefit with a corresponding reduction in its deferred tax liability in the nine months ended September 30, 2017 as a result of this reclassification.

Impairment of Long-Lived Assets:  Long-lived assets and certain identifiable intangible assets to be held and used are reviewed for impairment when events or changes in circumstances indicate that the carrying amount of such assets may not be recoverable. Recoverability of assets to be held and used is measured by comparison of the carrying amount of an asset to future net cash flows expected to be generated by the asset. If such assets are considered to be impaired, the impairment to be recognized is measured by the amount that the carrying amount of the assets exceeds the fair value of the assets. Assets to be disposed of are reported at the lower of the carrying amount or fair value less costs to sell. There was no impairment of long-lived assets in the nine months ended September 30, 2017 and 2016.

Indefinite lived intangible assets are also tested annually for impairment and whenever indicators of impairment are present. When performing the impairment assessment, the Company first assesses qualitative factors to determine whether it is necessary to recalculate the fair value of its intangible assets. If management believes, as a result of the qualitative assessment, that it is more likely than not that the fair value of the intangible assets is less than its carrying amount, the Company calculates the asset’s fair value. If the carrying value of the asset exceeds its fair value, then the intangible asset is written down to its fair value.

Goodwill Impairment:  Goodwill is not amortized, but is tested at least annually for impairment at the reporting unit level.  The Company has determined that the reporting unit is the single operating segment disclosed in its current financial statements. Impairment is the condition that exists when the carrying amount of goodwill exceeds its implied fair value.  The first step in the impairment process is to determine the fair value of the reporting unit and then compare it to the carrying value, including goodwill.  If the fair value exceeds the carrying value, no further action is required and no impairment loss is recognized.  Additional impairment assessments may be performed on an interim basis if the Company encounters events or changes in circumstances that would indicate that, more likely than not, the carrying value of goodwill has been impaired.  There was no impairment of goodwill in the nine months ended September 30, 2017 and 2016.

Revenue Recognition: Revenues are recognized when persuasive evidence of an arrangement exists, delivery has occurred or services have been rendered, the price is fixed or determinable and collectibility is reasonably assured.  

Product Revenues

Product revenues consist of U.S. sales of XERMELO and sales of bulk tablets of telotristat ethyl to Ipsen Pharma SAS (“Ipsen”). Product revenues are recognized once the Company meets all four revenue recognition criteria described above. In March 2017, Lexicon began shipping XERMELO to its customers in the U.S. The Company recognizes revenue for product sales of XERMELO at the time the product is received by its specialty pharmacy customers net of allowances for customer credits, including estimated rebates, chargebacks, discounts, returns, distribution service fees, and government rebates, such as Medicare Part D coverage gap reimbursements in the U.S. Product shipping and handling costs are included in cost of sales.

Customer Credits: The specialty pharmacies are offered various forms of consideration, including allowances, service fees and prompt payment discounts. Lexicon expects the specialty pharmacies will earn prompt payment discounts and, therefore, the Company deducts the full amount of these discounts from total product sales when revenues are recognized. Service fees are also deducted from product sales as they are earned.

Rebates: Allowances for rebates include mandated discounts under the Medicaid Drug Rebate Program. Rebate amounts are based upon contractual agreements or legal requirements with public sector (e.g. Medicaid) benefit providers. Rebates are amounts owed after the final dispensing of the product to a benefit plan participant and are based upon contractual agreements or legal requirements with public sector benefit providers. The allowance for rebates is based on statutory discount rates and expected utilization. The Company’s estimates for expected utilization of rebates are based in part on third party market research data, and data received from the specialty pharmacies. Rebates are generally invoiced and paid in arrears so that the accrual balance consists of an estimate of the amount expected to be incurred for the current quarter’s activity, plus an accrual balance for known prior quarter’s unpaid rebates. If actual future rebates vary from estimates, the Company may need to adjust prior period accruals, which would affect revenue in the period of adjustment.

Chargebacks: Chargebacks are discounts that occur when contracted customers purchase directly from a specialty pharmacy. Contracted customers, which currently consist primarily of Public Health Service institutions, non-profit clinics, and Federal government entities purchasing via the Federal Supply Schedule, generally purchase the product at a discounted price. The specialty pharmacy, in turn, charges back to Lexicon the difference between the price initially paid by the specialty pharmacy and the discounted price paid to the specialty pharmacy by the customer. The allowance for chargebacks is based on known sales to contracted customers.

Medicare Part D Coverage Gap: Medicare Part D prescription drug benefit mandates manufacturers to fund 50% of the Medicare Part D insurance coverage gap for prescription drugs sold to eligible patients. The Company’s estimates for the expected Medicare Part D coverage gap are based on data received from the specialty pharmacies. Funding of the coverage gap is generally invoiced and paid in arrears so that the accrual balance consists of an estimate of the amount expected to be incurred for the current quarter’s activity, plus an accrual balance for known prior quarters. If actual future funding varies from estimates, the Company may need to adjust prior period accruals, which would affect revenue in the period of adjustment.

Co-payment assistance: Patients who have commercial insurance and meet certain eligibility requirements may receive co-payment assistance. The Company accrues a liability for co-payment assistance based on actual program participation and estimates of program redemption using data provided by third-party administrators.

Collaborative Agreements

Revenues under collaborative agreements include both license revenue and contract research revenue. Activities under collaborative agreements are evaluated to determine if they represent a multiple element revenue agreement. The Company identifies the deliverables included within the agreement and evaluates which deliverables represent separate units of accounting. The Company accounts for those components as separate units of accounting if the following two criteria are met:

The delivered item or items have value to the customer on a stand-alone basis; and
If there is a general right of return relative to the delivered items, delivery or performance of the undelivered items is considered probable and within the Company’s control.


Factors considered in this determination include, among other things, whether any other vendors sell the items separately and if the licensee could use the delivered item for its intended purpose without the receipt of the remaining deliverables. If multiple deliverables included in an arrangement are separable into different units of accounting, the Company allocates the arrangement consideration to those units of accounting. The amount of allocable arrangement consideration is limited to amounts that are fixed or determinable. Arrangement consideration is allocated at the inception of the arrangement to the identified units of accounting based on their relative estimated selling price. Revenue is recognized for each unit of accounting when the appropriate revenue recognition criteria are met.

Future milestone payments that are contingent upon the achievement of a substantive milestone are recognized in their entirety in the period in which the milestone is achieved. A milestone is substantive if:

The consideration payable to the Company is commensurate with the Company’s performance necessary to achieve the milestone or the increase in value to the collaboration resulting from the Company’s performance;
Relates solely to the Company’s past performance; and
Is reasonable relative to all of the other deliverables and payments within the arrangement.

Commercial milestones will be accounted for as royalties and recorded as revenue upon achievement of the milestone, assuming all other revenue recognition criteria are met. Subscription and license fees are recognized as revenue uponpermit the grant of the technology license when performance is completestock options, restricted stock unit awards, and there is no continuing involvement. Royalty revenues are recognized as earned in accordance with the contract terms at the time the royalty amount is fixedother stock-based awards to employees, directors, and determinable based on information received from the sublicensees and at the time collectibility is reasonably assured.

Cost of Sales: Cost of sales consists of third-party manufacturing costs, freight and indirect overhead costs associated with sales of XERMELO. The Company began capitalizing inventory during the nine months ended September 30, 2017 once the FDA approved XERMELO as the related costs were expected to be recoverable through the commercializationconsultants of the product. Costs incurred priorCompany. Compensation expense related to approval of XERMELO have been recorded as research and development expense in the consolidated statements of comprehensive loss. As a result, cost of sales for approximately the next two years will reflect a lower average per unit cost of materials. Product shipping and handling costs are included in cost of sales. Cost of sales also includes the amortization of the in-process research and development intangible asset for XERMELO using the straight-line method over the estimated useful life of 14 years.

Research and Development Expenses: Research and development expenses consist of costs incurred for company-sponsored as well as collaborative research and development activities. These costs include direct and research-related overhead expenses and are expensed as incurred.  Technology license fees for technologies that are utilized in research and development and have no alternative future use are expensed when incurred. Substantial portions of the Company’s preclinical and clinical trials are performed by third-party laboratories, medical centers, contract research organizations and other vendors. For preclinical studies, the Company accrues expenses based upon estimated percentage of work completed and the contract milestones remaining. For clinical studies, expenses are accrued based upon the number of patients enrolled and the duration of the study. The Company monitors patient enrollment, the progress of clinical studies and related activities to the extent possible through internal reviews of data reported to the Company by the vendors and clinical site visits. The Company’s estimates depend on the timeliness and accuracy of the data provided by the vendors regarding the status of each program and total program spending. The Company periodically evaluates the estimates to determine if adjustments are necessary or appropriate based on information it receives.
Stock-Based Compensation:  The Company recognizes compensation expense in its consolidated statements of comprehensive loss for share-based payments, including stock options and restricted stock units issued to employees,(“RSUs”) is determined based on theirthe fair valuesvalue of the award on the date of the grant withand is recognized on a straight-line basis over the compensation expense recognized over thevesting period in which an employee is required to provide service in exchangeservice. Compensation expense of $4.3 million and $3.4 million for the stock award.  Stock-based compensationthree months ended March 31, 2024 and 2023, respectively, is recorded separately in research and development expense for awards without performance conditions is recognizedand selling, general, and administrative expense as noted on a straight-line basis. Stock-based compensation expense for awards with performance conditions is recognized over the period from the date the performance condition is determined to be probableCompany’s condensed consolidated statements of occurring through the time the applicable condition is met.  comprehensive loss.   
 
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The fair value of stock options is estimated at the date of grant using the Black-Scholes method.  The Black-Scholes option-pricing model requiresmethod requiring the input of subjective assumptions. Because the Company’s employee stock options have characteristics significantly different from those of traded options, and because changes in the subjective input assumptions can materially affect the fair value estimate, in management’s opinion, the existing models do not necessarily provide a reliable single measure of the fair value of its employee stock options. For purposes of determining the fair value of stock options, the Company segregates its options into two homogeneous groups, based on exercise and post-vesting employment termination behaviors, resulting in a change in thedifferent assumptions used for expected option lives and forfeitures.lives.  Historical data is used to estimate the expected option life for each group. Expected volatility is based

on the historical volatility in the Company’s stock price. The Company utilized the Black-Scholes valuation model for estimating the fair value of the stock compensation granted, with the following weighted-average assumptions were used for stock options granted in the ninethree months ended September 30, 2017March 31, 2024 and 2016:2023:
 Expected VolatilityRisk-free Interest RateExpected TermDividend
Rate
March 31, 2024    
Employees96 %4.3 %4— %
Officers and non-employee directors104 %4.2 %6— %
March 31, 2023
Employees112 %4.1 %4— %
Officers and non-employee directors98 %3.9 %6— %

  Expected Volatility Risk-free Interest Rate Expected Term 
Dividend
Rate
September 30, 2017:        
Employees 61% 1.7% 4 —%
Officers and non-employee directors 70% 2.2% 8 —%
September 30, 2016:        
Employees 63% 1.1% 4 —%
Officers and non-employee directors 83% 1.6% 8 —%

The following is a summary of stock option activity under Lexicon’s stock-based compensation plans for the ninethree months ended September 30, 2017:March 31, 2024:
 Stock OptionsWeighted Average Exercise Price
 (in thousands) 
Outstanding at December 31, 202318,705 $3.93 
Granted3,822 2.16 
Exercised(51)1.72 
Expired(148)12.04 
Forfeited(670)2.21 
Outstanding at March 31, 202421,658 3.62 
Exercisable at March 31, 20249,631 $5.03 

  Options Weighted Average Exercise Price
  (in thousands)  
Outstanding at December 31, 2016 4,834
 $11.24
Granted 847
 14.51
Exercised (458) 11.98
Expired (149) 26.59
Forfeited (82) 13.55
Outstanding at September 30, 2017 4,992
 11.23
Exercisable at September 30, 2017 2,896
 $11.06


During the nine months ended September 30, 2017, Lexicon also granted its employees annual restricted stock units. These restricted stock units vest in four annual installments. The following is a summary of restricted stock unitsunit activity under Lexicon’s stock-based compensation plans for the ninethree months ended September 30, 2017:March 31, 2024:
 RSU’sWeighted Average Grant Date
Fair Value
 (in thousands) 
Outstanding at December 31, 20235,015 $2.78 
Granted8,270 2.15 
Vested(1,921)3.12 
Forfeited(297)2.32 
Outstanding at March 31, 202411,067 $2.26 

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  Shares 
Weighted Average Grant Date
Fair Value
  (in thousands)  
Outstanding at December 31, 2016 875
 $8.13
Granted 418
 14.44
Vested (286) 8.78
Forfeited (38) 10.98
Outstanding at September 30, 2017 969
 $10.55

8.Other Capital Agreements
 
During the nine months ended September 30, 2017, Lexicon granted its non-employee directors 10,248 shares of restricted stock awards. The restricted stock awards had a weighted average grant date fair value of $15.61 per share and vested immediately.

Net Loss per Common Share: Net loss per common share is computed using the weighted average number of shares of common stock outstanding. Shares associated with convertible debt, stock options and restricted stock units are not included because they are antidilutive.


2.Recent Accounting Pronouncements
In May 2014, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) No. 2014-09, “Revenue from Contracts with Customers”, which amends FASB ASC Topic 606. ASU 2014-09 provides a single, comprehensive revenue recognition model for all contracts with customers. This standard contains principles for the determination of the measurement of revenue and the timing of when such revenue is recognized. Revenue recognition will reflect the transfer of goods or services to customers at an amount that is expected to be earned in exchange for those goods or services. In August 2015, the FASB issued ASU No. 2015-14, “Revenue from Contracts with Customers: Deferral of Effective Date”, which defers the effective date of ASU 2014-09 by one year. ASU 2014-09 is now effective for annual periods after December 15, 2017 including interim periods within that reporting period. Early application is permitted only for annual periods beginning after December 15, 2016, including interim periods within that reporting period. Management plans to adopt ASU 2014-09 using the modified retrospective method.
The Company does not expect that ASU 2014-09 will have a material impact on the recognition of revenue from product sales. Management is also currently evaluating the impact of the new standard on historical revenue recorded for its collaboration agreements. Specifically, the timing of recognition for certain contingent payments from the Company’s collaborators may be impacted by the adoption of the new revenue standard. ASU 2014-09 differs from the current accounting standard in many respects, such as in the accounting for variable consideration, including milestone payments or contingent payments, which are not dependent on the Company’s performance. Under the Company’s current accounting policy, Lexicon recognizes contingent or milestone payments as revenue in the period that the payment-triggering event occurs or is achieved. However, under the new revenue standard, it is possible to start to recognize contingent or milestone payments before the payment-triggering event is completely achieved, subject to management’s assessment of whether it is probable that a significant reversal in the amount of cumulative revenue recognized will not occur when the uncertainty associated with the variable consideration is subsequently resolved.
In January 2016, the FASB issued ASU No. 2016-01, “Recognition and Measurement of Financial Assets and Financial Liabilities.” ASU 2016-01 requires that most equity investments be measured at fair value, with subsequent changes in fair value recognized in net income. The pronouncement also impacts financial liabilities under the fair value option and the presentation and disclosure requirements for financial instruments. This pronouncement is effective for fiscal years, and interim periods within those years, beginning after December 15, 2017, and early adoption is not permitted. Management does not expect the adoption of this pronouncement to have a material impact on Lexicon’s consolidated financial statements.
In February 2016, the FASB issued ASU No. 2016-02, “Leases.” ASU 2016-02 requires companies that lease assets to recognize a right-of-use asset and a lease liability, initially measured at the present value of the lease payments, in its balance sheet. The pronouncement will also require additional disclosures about the amount, timing and uncertainty of cash flows arising from leases. This pronouncement is effective for fiscal years, and interim periods within those years, beginning after December 15, 2018, and early adoption is permitted. Management is currently evaluating the impact of this pronouncement on Lexicon’s consolidated financial statements.
InConvertible Preferred Stock. On March 2016, the FASB issued ASU No. 2016-09, “Stock Compensation,” which is intended to simplify several aspects of the accounting for share-based payment award transactions. The Company adopted this pronouncement effective January 1, 2017. Upon adoption, the Company recognized approximately $6.1 million of accumulated excess tax benefits as deferred tax assets that under the previous guidance could not be recognized until the benefits were realized through a reduction in cash taxes paid. This part of the guidance is applied using a modified retrospective method with a cumulative-effect adjustment to the accumulated deficit for the excess tax benefits not previously recognized. However, given the full valuation allowance placed on the additional $6.1 million of deferred tax assets, the recognition of this provision of ASU 2016-09 had no impact to the Company’s accumulated deficit as of January 1, 2017. Additionally, the Company recorded an adjustment to accumulated deficit of $2.0 million as a result of making an entity-wide accounting policy election to account for forfeitures of share-based payment awards as they occur instead of estimating the number of awards that are expected to vest.


3.Cash and Cash Equivalents and Investments
The fair value of cash and cash equivalents and investments held at September 30, 2017 and December 31, 2016 are as follows:
  As of September 30, 2017
  Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Estimated Fair Value
  (in thousands)
Cash and cash equivalents $83,293
 $—
 $—
 $83,293
Securities maturing within one year:        
U.S. treasury securities 90,533
 —
 (57) 90,476
Corporate debt securities 23,054
 —
 (6) 23,048
Total short-term investments $113,587
 $—
 $(63) $113,524
Total cash and cash equivalents and investments $196,880
 $—
 $(63) $196,817
         
  As of December 31, 2016
  Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Estimated Fair Value
    (in thousands)  
Cash and cash equivalents $46,600
 $—
 $—
 $46,600
Securities maturing within one year:        
U.S. treasury securities 227,911
 1
 (107) 227,805
Corporate debt securities 72,188
 1
 (90) 72,099
Total short-term investments $300,099
 $2
 $(197) $299,904
Total cash and cash equivalents and investments $346,699
 $2
 $(197) $346,504

There were $7,000 in realized losses for the nine months ended September 30, 2017, and no realized gains or losses for the nine months ended September 30, 2016. The cost of securities sold is based on the specific identification method.

4.Fair Value Measurements
The Company uses various inputs in determining the fair value of its investments and measures these assets on a recurring basis. Assets and liabilities recorded at fair value in the consolidated balance sheets are categorized by the level of objectivity associated with the inputs used to measure their fair value. The following levels are directly related to the amount of subjectivity associated with the inputs to fair valuation of these assets and liabilities:

Level 1 - quoted prices in active markets for identical investments, which include U.S. treasury securities
Level 2 - other significant observable inputs (including quoted prices for similar investments, market corroborated inputs, etc.), which includes corporate debt securities
Level 3 - significant unobservable inputs (including the Company’s own assumptions in determining the fair value of the Symphony Icon purchase consideration liability)

The inputs or methodology used for valuing securities are not necessarily an indication of the credit risk associated with investing in those securities. The following table provides the fair value measurements of applicable Company assets and liabilities that are measured at fair value on a recurring basis according to the fair value levels described above as of September 30, 2017 and December 31, 2016:

  Assets and Liabilities at Fair Value as of September 30, 2017
  Level 1 Level 2 Level 3 Total
  (in thousands)
Assets        
Cash and cash equivalents $83,293
 $—
 $—
 $83,293
Short-term investments 90,476
 23,048
 —
 113,524
Total cash and cash equivalents and investments $173,769
 $23,048
 $—
 $196,817
  Assets and Liabilities at Fair Value as of December 31, 2016
  Level 1 Level 2 Level 3 Total
  (in thousands)
Assets        
Cash and cash equivalents $45,093
 $1,507
 $—
 $46,600
Short-term investments 227,805
 72,099
 —
 299,904
Total cash and cash equivalents and investments $272,898
 $73,606
 $—
 $346,504
Liabilities        
Accrued liabilities $—
 $—
 $18,912
 $18,912
Total liabilities $—
 $—
 $18,912
 $18,912
The Company’s Level 3 liabilities, which consisted of the Symphony Icon purchase consideration liability, was estimated using a probability-based income approach utilizing an appropriate discount rate. Subsequent changes in the fair value of the Symphony Icon purchase consideration liability were recorded as an increase or decrease in Symphony Icon purchase liability expense in the accompanying consolidated statements of comprehensive loss. The following table summarizes the change in consolidated balance sheet carrying value associated with Level 3 liabilities for the nine months ended September 30, 2017 and 2016 (in thousands):
Balance at December 31, 2016 $18,912
Change in valuation of purchase consideration payable to former Symphony Icon stockholders 2,101
Payment of contingent payment obligation with common stock and cash (21,013)
Balance at September 30, 2017 $—
   
Balance at December 31, 2015 $22,815
Change in valuation of purchase consideration payable to former Symphony Icon stockholders (703)
Payment of contingent payment obligation with cash (3,200)
Balance at September 30, 2016 $18,912
The Company also has assets that under certain conditions are subject to measurement at fair value on a non-recurring basis. These assets include goodwill associated with the acquisitions of Coelacanth Corporation in 2001 and Symphony Icon in 2010 and intangible assets associated with the acquisition of Symphony Icon in 2010. See Note 6, Arrangements with Symphony Icon, Inc., for additional information. For these assets, measurement at fair value in periods subsequent to their initial recognition is applicable if one or more is determined to be impaired.

5.Debt Obligations
Convertible Debt. In November 2014, Lexicon completed an offering of $87.5 million in aggregate principal amount of its 5.25% Convertible Senior Notes due 2021 (the “Notes”). The conversion feature did not meet the criteria for bifurcation as required by generally accepted accounting principles and the entire principal amount was recorded as long-term debt on the Company’s consolidated balance sheets.

The Notes are governed by an indenture (the “Indenture”), dated as of November 26, 2014, between the Company and Wells Fargo Bank, N.A., as trustee. The Notes bear interest at a rate of 5.25% per year, payable semiannually in arrears on June 1 and December 1 of each year, beginning on June 1, 2015. The Notes mature on December 1, 2021. The Company may not redeem the Notes prior to the maturity date, and no sinking fund is provided for the Notes.
Holders of the Notes may convert their Notes at their option at any time prior to the close of business on the business day immediately preceding the maturity date. Upon conversion, the Company will deliver for each $1,000 principal amount of converted Notes a number of shares of its common stock equal to the conversion rate, as described in the Indenture. The conversion rate is initially 118.4553 shares of common stock per $1,000 principal amount of Notes (equivalent to an initial conversion price of $8.442 per share of common stock). The conversion rate is subject to adjustment in some events but will not be adjusted for any accrued and unpaid interest. In addition, following certain corporate events that occur prior to the maturity date, the Company will increase the conversion rate for a holder who elects to convert its Notes in connection with such a corporate event in certain circumstances.
If the Company undergoes a fundamental change, holders may require the Company to repurchase for cash all or any portion of their Notes at a fundamental change repurchase price equal to 100% of the principal amount of the Notes to be repurchased, plus accrued and unpaid interest to, but excluding, the fundamental change repurchase date.
In connection with the issuance of the Notes, the Company incurred $3.4 million of debt issuance costs, which offsets long-term debt on the consolidated balance sheets. The debt issuance costs are amortized as interest expense over the expected life of the Notes using the effective interest method. The Company determined the expected life of the debt was equal to the seven-year term of the Notes. As of September 30, 2017, the balance of unamortized debt issuance costs was $2.0 million.
The fair value of the Notes was $141.6 million as of September 30, 2017 and was determined using Level 2 inputs based on the indicative pricing published by certain investment banks or trading levels of the Notes, which are not listed on any securities exchange or quoted on an inter-dealer automated quotation system.
Mortgage Loan.  In April 2004, Lexicon obtained a $34.0 million mortgage on its facilities in The Woodlands, Texas.  The mortgage loan originally had a ten-year term with a 20-year amortization and a fixed interest rate of 8.23%. The mortgage was amended in September 2013 to extend the maturity date from April 2014 to April 2017, with the mortgage loan’s monthly payment amount and fixed interest rate each remaining unchanged. In April 2017, the mortgage was amended to extend the maturity date to April 2018, with the mortgage loan’s monthly payment amount and fixed interest rate each remaining unchanged.  The mortgage had a principal balance outstanding of $14.7 million as of September 30, 2017. This entire balance is recorded as current portion of long-term debt in the accompanying consolidated balance sheet as of September 30, 2017 as there is a balloon payment due in April 2018. The buildings and land that serve as collateral for the mortgage loan are included in property and equipment at $59.2 million and $2.7 million, respectively, before accumulated depreciation, as of September 30, 2017. The fair value of Lexicon’s mortgage loan approximates its carrying value.  The fair value of Lexicon’s mortgage loan was determined using Level 2 inputs using discounted cash flow analysis, based on the Company’s estimated current incremental borrowing rate.


6.Arrangements with Symphony Icon, Inc.
On June 15, 2007,11, 2024, Lexicon entered into a series of related agreements providing for the financing of the clinical development ofan agreement with certain of its drug candidates, including XERMELO, along with any other pharmaceutical compositions modulating the same targets as those drug candidates (the “Programs”). The agreements included a Novated and Restated Technology License Agreementaccredited investors pursuant to which the Company licensedagreed to Symphony Icon, a then wholly-owned subsidiary of Symphony Icon Holdings LLC (“Holdings”), the Company's intellectual property rights related to the Programs. Holdings contributed $45 million to Symphony Icon in order to fund the clinical development of the Programs.

Under a Share Purchase Agreement, dated June 15, 2007, between the Company and Holdings, the Company issued and sold to Holdings 1,092,946sell 2,304,147 shares of its commonSeries A Convertible Preferred Stock, par value $0.01 per share, in a private placement at a price of $108.50 per share. The Company received net proceeds of approximately $242 million, after deducting placement agent fees and offering expenses from the private placement offering. Each share of preferred stock on June 15, 2007 in exchange for $15 million and an exclusive purchase option (the “Purchase Option”) that gave the Company the right to acquire all of the equity of Symphony Icon, thereby allowing the Company to reacquire all of the Programs. On July 30, 2010, Lexicon enteredis convertible into an Amended and Restated Purchase Option Agreement (the “Purchase Option Agreement”) with Symphony Icon and Holdings and simultaneously exercised the Purchase Option, thereby reacquiring the Programs. Pursuant to the amended terms of the Purchase Option, Lexicon paid Holdings $10 million on July 30, 2010 and issued 1,891,07450 shares of common stock following the approvals listed below. An affiliate of Invus, L.P. elected to designees of Holdingsparticipate on July 30, 2012 in satisfaction of an additional $35 million base payment obligation.
Lexicon also agreed to make up to $45 million in additional contingent payments, which would consist of 50% of any consideration Lexicon receives pursuant to any licensing transaction (a “Licensing Transaction”) under which Lexicon grants a third party rights to commercialize XERMELO or other pharmaceutical compositions modulating the same targetterms as XERMELO (the “LG103 Programs”), subject to certain exceptions. The contingent payments would be due if and when Lexicon receives such consideration fromeach other purchaser on a Licensing Transaction. In the event Lexicon received regulatory approval in the United States for the marketing and sale of any product resulting from the LG103 Programs prior to entering into a Licensing Transaction for the commercialization of such product in the United States, in lieu of any contingent payment from such a Licensing Transaction, Lexicon would pay Holdings the sum of $15 million and the amount of certain expenses Lexicon incurred after its exercise of the Purchase Option which were attributable to the development of such product, reduced by up to 50% of such sum on account of any contingent payments paid prior to such United States regulatory approval attributable to any such Licensing Transaction outside of the United States with respect to such product. In the event Lexicon made any such payment upon United States regulatory approval, Lexicon would have no obligation to make subsequent contingent payments attributable to any such Licensing Transactions for the commercialization of such product outside the United States until the proceeds of such Licensing Transactions exceed 50% of the payment made as a result of such United States regulatory approval. The contingent payments were payable in cash or a combination of cash and common stock, in Lexicon’s discretion, provided that no more than 50% of any contingent payment would be paid in common stock. In December 2014, Lexicon paid $5.8 million in cash and issued 666,111 shares of common stock to designees of Holdings in satisfaction of a $11.5 million contingent payment obligation as a result of receiving an upfront payment pursuant to Lexicon’s license and collaboration agreement with Ipsen. In April 2015, Lexicon paid $0.75 million in cash to Holdings in satisfaction of its contingent payment obligation as a result of receiving an additional upfront payment from Ipsen in March 2015. In September 2016, Lexicon paid $3.2 million in cash to Holdings in satisfaction of its contingent payment obligation as a result of receiving a milestone payment from Ipsen in August 2016 (see Note 8, Collaboration and License Agreements).
In September 2016, Lexicon entered into an amendment (the “Amendment”) to the Purchase Option Agreement with Holdings and Symphony Icon pursuant to which Lexicon agreed to pay Holdings $21.0 million upon Lexicon’s receipt of regulatory approval in the United States for the marketing and sale of XERMELO, such buyout amount to be in lieu of any remaining payments which may be or become payable to Holdings under the Purchase Option Agreement. The buyout amount may be paid in cash or a combination of cash and common stock, in Lexicon’s discretion, provided that no more than 50% of any contingent payment will be paid in common stock. In March 2017, Lexicon paid $10.5 million in cash and issued 659,905 shares of common stock to designees of Holdings in satisfaction of its remaining contingent payment obligation as a result of receiving regulatory approval in the United States for the marketing and sale of XERMELO.
Lexicon accounted for the exercise of the Purchase Option and acquisition of Symphony Icon as a business combination. In connection with its acquisition of Symphony Icon, Lexicon paid $10.0 million in cash,pro rata basis and also agreed to pay Holdings additional base and contingent payments as discussed above. The fair valuevote at the Company’s 2024 annual meeting of stockholders in favor of the base and contingent consideration payments was $45.6 million and was estimated by applying a probability-based income approach utilizingapproval of an appropriate discount rate. This estimation was based on significant inputs that are not observable inamendment to the market, referredCompany’s certificate of incorporation increasing the total authorized common shares thereunder from 300,000,000 to as Level 3 inputs. Key assumptions include: (1) a discount rate of 14% for450,000,000 shares (the “New Charter”).

Following the base payments; (2) a discount rate of 18% for the contingent payments; and (3) a probability adjusted contingency. No discount rate was used in the valuationapproval of the contingent consideration liability as of December 31, 2016 asNew Charter by the expected buyout was short-term in nature. As programs progress,Company’s shareholders, the probability adjusted contingency was adjusted as necessary. Subsequent changes in the fair valueadoption of the Symphony Icon purchase consideration liability were recorded as increase or decrease in fair valueNew Charter by the Company’s board of Symphony Icon purchase liability expense in the accompanying consolidated statements of comprehensive loss. The fair value of the Symphony Icon purchase consideration liability increased by $2.1 million during the nine months ended September 30, 2017 and decreased by $0.7 million during the nine months ended September 30, 2016.


7.      Commitments and Contingencies
Operating Lease Obligations:  A Lexicon subsidiary leases office space in Basking Ridge, New Jersey under an operating lease agreement, the term of which began in June 2015 and terminates in December 2022. Rent expense is recognized on a straight-line basis over the lease term.  The maximum potential amount of future payments the Company could be required to make under this agreement is $3.3 million as of September 30, 2017. Additionally, Lexicon leases certain equipment under operating leases.
Legal Proceedings.  Lexicon is from time to time party to claims and legal proceedings that arise in the normal course of its business and that it believes will not have, individually or in the aggregate, a material adverse effect on its results of operations, financial condition or liquidity.
8.Collaboration and License Agreements
Lexicon has derived substantially all of its revenues from drug discovery and development collaborations, target validation collaborations for the development and, in some cases, analysis of the physiological effects of genes altered in knockout mice, product sales, government grants and contracts, technology licenses, subscriptions to its databases and compound library sales.
Sanofi. In November 2015, Lexicon entered into a Collaboration and License Agreement, which was subsequently amended in July 2017 (collectively, the “Sanofi Agreement”), with Sanofi for the worldwide development of Lexicon’s diabetes drug candidate sotagliflozin. In December 2016, Sanofi terminated its rights under the Sanofi Agreement with respect to Japan.
Under the Sanofi Agreement, Lexicon has granted Sanofi an exclusive, worldwide (excluding Japan), royalty-bearing right and license under its patent rights and know-how to develop, manufacture and commercialize sotagliflozin. Subject to specified exceptions, neither party may (a) perform clinical development activities relating to any other compound which inhibits sodium-glucose cotransporters type 1 or type 2 or (b) commercialize any such compounds in the United States, countries of the European Union and certain other specified countries, in each case during the royalty terms applicable in such countries. Among the specified exceptions is a right Lexicon retained to pursue the development of its LX2761 drug candidate, with respect to which Lexicon granted Sanofi certain rights of first negotiation specified in the Sanofi Agreement.
Under the Sanofi Agreement, Sanofi paid Lexicon an upfront payment of $300 million. In addition, Lexicon is eligible to receive from Sanofi (a) up to an aggregate of $110 million upon the achievement of four development milestones relating to the results of certain Phase 3 clinical trials of sotagliflozin in type 2 diabetes patients, (b) up to an aggregate of $220 million upon the achievement of four regulatory milestones relating to the first commercial sale following regulatory approval of sotagliflozin for type 1 and type 2 diabetes, respectively, in each of the United States and Europe, of which two milestones representing the substantial majority of such aggregate amount relate to type 2 diabetesdirectors, and the remaining two milestones relate to type 1 diabetes, (c) $100 million upon the achievement of a milestone based on the results of either of two outcomes studies in type 2 diabetes patients, the completion of which would likely occur after initial regulatory approval of sotagliflozin in type 2 diabetes,filing and (d) up to an aggregate of $990 million upon the achievement of six commercial milestones that will be achieved upon reaching specified levels of sales. The Company believes that each of the development and regulatory milestones under the Sanofi Agreement is substantive. Due to the uncertainty surrounding the achievement of the future development and regulatory milestones, these payments will not be recognized as revenue unless and until they are earned, as the Company is not able to reasonably predict if and when the milestones will be achieved. Commercial milestones, which are not encompassed within the definition of milestones under generally accepted accounting principles, will be accounted for as royalties and recorded as revenue upon achievement of the milestone, assuming all other revenue recognition criteria were met. Lexicon is also entitled to tiered, escalating royalties ranging from low double digit percentages to forty percent of net sales of sotagliflozin, based on indication and territory, with royalties for the higher band of such range attributable to net sales for type 1 diabetes in the United States, and subject in each case to customary royalty reduction provisions.
Lexicon will continue to be responsible for all clinical development activities relating to type 1 diabetes and has exercised an exclusive option to co-promote and have a significant role, in collaboration with Sanofi, in the commercialization of sotagliflozin for the treatment of type 1 diabetes in the United States. Under the terms of its exercised co-promotion option, Lexicon will fund forty percent of the commercialization costs relating to such co-promotion activities. Sanofi will be responsible for all clinical development and commercialization of sotagliflozin for the treatment of type 2 diabetes worldwide and will be solely responsible for the commercialization of sotagliflozin for the treatment of type 1 diabetes outside the United States. Lexicon will share in the funding of a portion of the planned type 2 diabetes development costs over the next three years, up to an aggregate of $100 million. Sanofi will book sales worldwide in all indications.

The parties are responsible for using commercially reasonable efforts to perform their development and commercialization obligations pursuant to mutually approved development and commercialization plans.
The parties’ activities under the Sanofi Agreement are governed by a joint steering committee and certain other governance committees which reflect equal or other appropriate representation from both parties. If the applicable governance committee is not able to make a decision by consensus and the parties are not able to resolve the issue through escalation to specified senior executive officers of the parties, then Sanofi will have final decision-making authority, subject to limitations specified in the Sanofi Agreement.
The Sanofi Agreement will expire upon the expiration of all applicable royalty terms for all licensed products in all countries. The royalty term for each licensed product in each country is the period commencing on the effective date of the Sanofi Agreement and ending on the latest of expiration of specified patent coverage, expiration of specified regulatory exclusivity and 10 years following the first commercial sale in the applicable country. Either party may terminate the Sanofi Agreement in the event of an uncured material breach by the other party. Prior to completion of the core development activities for type 2 diabetes specified in the development plan, Sanofi may terminate the Sanofi Agreement on a country-by-country and licensed product-by-licensed product basis, in the event of (a) notification of a material safety issue relating to the licensed product or the class of sodium-glucose cotransporters type 1 or type 2 inhibitors resulting in a recommendation or requirement that Lexicon or Sanofi cease development, (b) failure to achieve positive results with respect to certain clinical trial results, (c) the occurrence of specified fundamental adverse events or (d) the exploitation of the licensed product infringing third party intellectual property rights in specified major markets and Sanofi is unable to obtain a license to such third party intellectual property rights.
The Company considered the following deliverables with respect to the revenue recognition of the $300 million upfront payment:
• The exclusive worldwide license granted to Sanofi to develop and commercialize sotagliflozin;
• The development services Lexicon is performing for sotagliflozin relating to type 1 diabetes; and
• The funding Lexicon will provide for development relating to type 2 diabetes.
The Company determined that the license had stand-alone value because it is an exclusive license that gives Sanofi the right to develop and commercialize sotagliflozin or to sublicense its rights. In addition, sotagliflozin is currently in development and it is possible that Sanofi or another third party could conduct clinical trials without assistance from Lexicon. As a result, the Company considers the license and the development services under the Sanofi Agreement to be separate units of accounting. The Company recognized the portion of the consideration allocated to the license immediately because Lexicon delivered the license and earned the revenue at the inception of the arrangement. The Company is recognizing as revenue the amount allocated to the development services for type 1 diabetes and the obligation to provide funding for development services for type 2 diabetes over the period of time Lexicon performs services or provides funding, currently expected to be through 2020.
The Company determined that the initial allocable arrangement consideration was the $300 million upfront payment because it was the only payment that was fixed and determinable at the inception of the arrangement. There was considerable uncertainty at the date of the agreement as to whether Lexicon would earn milestone payments or royalty payments. As such, the Company did not include those payments in the allocable consideration. The Company allocated the allocable consideration based on the relative best estimate of selling price of each unit of accounting. The Company estimated the selling price of the license deliverable by applying a probability-based income approach utilizing an appropriate discount rate. The significant inputs the Company used to determine the projected income of the license included: exercising the option to co-promote, estimated future product sales, estimated cost of goods sold, estimated operating expenses, income taxes, and an appropriate discount rate. The Company estimated the selling price of the development services for type 1 diabetes by using internal estimates of the cost to hire third parties to perform the services over the expected period to perform the development. The Company estimated the obligation to provide funding for type 2 diabetes by using internal estimates of the expected cash flows and timing for $100 million in funding.
As a result of the allocation, the Company recognized $126.8 million of the $300 million upfront payment for the license in 2015. The Company is recognizing the $113.8 million allocated to the development services deliverable and the $59.4 million allocated to the funding deliverable over the estimated period of performance as the development and funding occurs. Revenue recognized under the Sanofi Agreement was $39.5 million and $52.7 million for the nine months ended September 30, 2017 and 2016, respectively.

Ipsen Pharma SAS. In October 2014, Lexicon entered into a License and Collaboration Agreement, which was subsequently amended in March 2015 (collectively, the “Ipsen Agreement”), with Ipsen for the development and commercialization of telotristat ethyl outside of the United States and Japan (the “Licensed Territory”).
Under the Ipsen Agreement, Lexicon granted Ipsen an exclusive, royalty-bearing right and license under its patent rights and know-how to commercialize telotristat ethyl in the Licensed Territory. Ipsen is responsible for using diligent efforts to commercialize telotristat ethyl in the Licensed Territory pursuant to a mutually approved commercialization plan. Subject to certain exceptions, Lexicon will be responsible for conducting clinical trials required to obtain regulatory approval for telotristat ethyl for carcinoid syndrome in the European Union, including those contemplated by a mutually approved initial development plan, and will have the first right to conduct most other clinical trials of telotristat ethyl. Lexicon is responsible for the costs of all clinical trials contemplated by the initial development plan. The costs of additional clinical trials will be allocated between the parties based on the nature of such clinical trials. Under the Ipsen Agreement, Ipsen has paid Lexicon an aggregate of $30.9 million through September 30, 2017, consisting of $24.5 million in upfront payments and a $6.4 million milestone payment in August 2016 upon the acceptance of the filing submittedNew Charter by Ipsenthe Secretary of State of Delaware, each share of preferred stock will automatically convert into 50 shares (subject to adjustments) of common stock, or approximately 115 million additional common shares in total. Our convertible preferred shares, as well as other potentially dilutive securities, are not included in the European Medicines Agency for telotristat ethylcalculation of diluted earnings per common share as an adjunct to somatostatin analog therapywe have reported a net loss for the long-term treatment of carcinoid syndrome. In September 2017, Ipsen received approval from the European Commission for the marketing of telotristat ethyl in all member states of the European Union, Norway and Iceland, thereby Lexicon earning a milestone payment, which was received in October 2017. In addition, Lexicon is eligible to receive from Ipsen (a) up to an aggregate of approximately $21 million upon the achievement of specified regulatory and commercial launch milestones and (b) up to an aggregate of €72 million upon the achievement of specified sales milestones. Due to the uncertainty surrounding the achievement of the future regulatory and sales milestones, these payments will not be recognized as revenue unless and until they are earned as the Company is not able to reasonably predict if and when the milestones will be achieved. Lexicon is also entitled to tiered, escalating royalties ranging from low twenties to mid-thirties percentages of net sales of telotristat ethyl in the Licensed Territory, subject to a credit for amounts previously paid to Lexicon by Ipsen for the manufacture and supply of such units of telotristat ethyl. Lexicon and Ipsen have entered into a commercial supply agreement pursuant to which Lexicon will supply Ipsen’s commercial requirements of telotristat ethyl, and Ipsen will pay an agreed upon transfer price for such commercial supply.
The Company considered the following deliverables with respect to the revenue recognition of the $24.5 million upfront payments:
The exclusive license granted to Ipsen to develop and commercialize telotristat ethyl in the Licensed Territory;
•The development services Lexicon is performing for telotristat ethyl;
The obligation to participate in committees which govern the development of telotristat ethyl until commercialization; and
•The obligation to supply commercial supply of telotristat ethyl, under a commercial supply agreement.

The Company determined that the license had stand-alone value because it is an exclusive license that gives Ipsen the right to develop and commercialize telotristat ethyl or to sublicense its rights. In addition, telotristat ethyl is currently in development and it is possible that Ipsen or another third party could conduct clinical trials without assistance from Lexicon. As a result, the Company considers the license and the development services under the Ipsen Agreement to be separate units of accounting. The Company recognized the portion of the consideration allocated to the license immediately because Lexicon delivered the license and earned the revenue at the inception of the arrangement. The Company is recognizing as revenue the amount allocated to the development services and the obligation to participate in committees over the period of time Lexicon performs services, currently expected to be complete by mid-2018.
Due to the inherent uncertainty in obtaining regulatory approval, the applicability of the commercial supply agreement is outside the control of Lexicon and Ipsen. Accordingly, the Company has determined the commercial supply agreement is a contingent deliverable at the onset of the Ipsen Agreement. As a result, the Company has determined the commercial supply agreement does not meet the definition of a deliverable that needs to be accounted for at the inception of the arrangement. The Company has also determined that there is no significant and incremental discount related to the commercial supply agreement that should be accounted for at the inception of the arrangement.
The Company determined that the initial allocable arrangement consideration was the $24.5 million upfront payments because they were the only payments that were fixed and determinable at the inception of the arrangement. There was considerable uncertainty at the date of the agreement as to whether Lexicon would earn milestone payments, royalty payments or payments for finished drug product. As such, the Company did not include those payments in the allocable consideration. The Company allocated the allocable consideration based on the relative best estimate of selling price of each unit of accounting. The Company estimated the selling price of the license deliverable by applying a probability-based income approach utilizing an appropriate discount rate. The significant inputs the Company used to determine the projected income of

the license included: estimated future product sales, estimated cost of goods sold, estimated operating expenses, income taxes, and an appropriate discount rate. The Company estimated the selling price of the development services by using internal estimates of the cost to hire third parties to perform the services over the expected period to perform the development. The Company estimated the selling price of the obligation to participate in committees by using internal estimates of the number of internal hours and salary and benefits costs to perform these services.
As a result of the allocation, the Company recognized $21.2 million of the $24.5 million upfront payments for the license in 2014, and an additional $1.4 million in 2015 upon entering into the amendment. The Company is recognizing the $1.7 million allocated to the development services deliverable over the estimated period of performance as development occurs, and is recognizing the $0.1 million allocated to the committee participation deliverable ratably over the estimated period of performance. Milestone payments that are contingent upon the achievement of a substantive milestone are recognized in their entirety in the period in which the milestone is achieved. The Company recognized the $5.1 million milestone payment earned in 2017 in the three and nine months ended September 30, 2017,March 31, 2024 and recognized the $6.4 million milestone payment earned in 2016 in the three2023, and nine months ended September 30, 2016. Revenue recognized under the Ipsen Agreement was $7.9 million and $6.8 million for the nine months ended September 30, 2017 and 2016, respectively. Revenue for the nine months ended September 30, 2017 includes $0.8 million from sales of bulk tablets of telotristat ethyl to Ipsen.their effect would be anti-dilutive.

13

Item 2.Management’s Discussion and Analysis of Financial Condition and Results of Operations
Item 2.  Management’s Discussion and Analysis of Financial Condition and Results of Operations
 
Overview
 
We are a biopharmaceutical company focused on the development and commercializationwith a mission of breakthrough treatments for human disease.pioneering medicines that transform patients’ lives. We are presently devoting most of our resources to the commercialization orof our approved drug and the research and development of our four most advanced drug programs:candidates:


•
We have obtained approval from the FDA to sell our first commercial product, XERMELO® (telotristat ethyl), an orally-delivered small molecule drug for the treatment of carcinoid syndrome diarrhea in combination with somatostatin analog, or SSA, therapy in adults inadequately controlled by SSA therapy. We have commenced sales and marketing of XERMELO, and it is now commercially available to patients in the United States. We have granted Ipsen Pharma SAS an exclusive, royalty-bearing right to commercialize XERMELO outside of the United States and Japan, and Ipsen has obtained approval from the European Commission to market XERMELO in the member states of the European Union, Norway and Iceland.
•We are developing sotagliflozin,commercializing INPEFA, an orally-delivered small molecule drug, candidate,in the United States to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visits in adults with heart failure or type 2 diabetes mellitus, chronic kidney disease, or CKD, and other cardiovascular risk factors.
We are separately pursuing regulatory approval of sotagliflozin as a treatment for type 1 diabetes. The U.S. Food and Drug Administration, or FDA, issued a complete response letter regarding our New Drug Application, or NDA, for sotagliflozin in type 2 diabetes.1 diabetes in March 2019, which we appealed. Following FDA feedback from recent discussions, we are now preparing to resubmit our NDA for patients with type 1 diabetes and CKD. We have reported positive top-line dataresults from two pivotalthree Phase 3 clinical trials of sotagliflozin in type 1 diabetes.

We are also developing sotagliflozin as a treatment for hypertrophic cardiomyopathy, or HCM, and are preparing to initiate a third Phase 3 clinical trial of sotagliflozin in type 1 diabetes patients. We have granted Sanofi an exclusive, worldwide (excluding Japan), royalty-bearing right to develop, manufacture and commercialize sotagliflozin, and Sanofi is presently conducting Phase 3 development of sotagliflozin in type 2 diabetes.HCM.
We are developing LX2761, an orally-delivered small molecule drug candidate, as a treatment for diabetes. We are presently conducting Phase 1 clinical development of LX2761. We have granted Sanofi certain rights of first negotiation with respect to the future development and commercialization of LX2761.
•We are developing LX9211, an orally-delivered small molecule drug candidate, as a treatment for neuropathic pain. We are presently conducting a Phase 12b clinical trial of LX9211 in diabetic peripheral neuropathic pain, or DPNP, and have received Fast Track designation from the FDA for development of LX9211 in that indication. We have reported positive results from a Phase 2 clinical trial of LX9211 in DPNP and top-line results from a separate Phase 2 clinical trial of LX9211 in post-herpetic neuralgia which also demonstrated evidence of effect.
•We are conducting preclinical development of LX9851, an orally-delivered small molecule drug candidate, as a treatment for obesity and tool for weight management.

•We are conducting preclinical research and development and preparing to conduct clinical development of LX9211.
Compounds from our most advanced drug programs, as well as compounds from a number of additional drug programs originating from our internal drug discovery efforts.

INPEFA, LX9851 and developmentcompounds from a number of additional drug programs that we have advanced into various stages of clinical and preclinical development, originated from our own internal drug discovery efforts. Theseefforts, and LX9211 originated from our collaborative neuroscience drug discovery efforts with Bristol-Myers Squibb. Our efforts were driven by a systematic, target biology-driven approach in which we used gene knockout technologies and an integrated platform of advanced medical technologies to systematically study the physiological and behavioral functions of almost 5,000 genes in mice and assessed the utility of the proteins encoded by the corresponding human genes as potential drug targets. We have identified and validated in living animals, or in vivo,, more than 100 targets with promising profiles for drug discovery.


We are workinghave worked both independently and through strategic collaborations and strategic alliances with third parties to capitalize on our drug target discoveries and drug discoveryresearch and development programs. We seek to retain exclusive or co-exclusive rights to the benefits of certain drug discoveryresearch and development programs by developing and commercializing drug candidates from those programs internally, particularly in the United States for indications treated by specialist physicians. We seek to collaborate with other pharmaceutical and biotechnology companies such as Ipsen and Sanofi, with respect to drug discovery or the research, development and commercialization of certain of our drug candidates, particularly with respect to commercialization in territories outside the United States or commercialization in the United States for indications treated by primary care physicians, or when the collaboration may otherwise provide us with access to expertise and resources that we do not possess internally or are complementary to our own.


We commercially launched XERMELO following regulatory approval in February 2017 for the treatment of carcinoid syndrome diarrhea in combination with SSA therapy in adults inadequately controlled by SSA therapy in the United States. Prior to the launch of XERMELO, wehave derived substantially all of our revenues from strategic collaborations and other research and development collaborations and technology licenses.licenses, as well as from commercial sales of our approved drug products. To date, we have generated a substantial portion of our revenues from a limited number of sources.


Our operating results and, in particular, our ability to generate additional revenues are dependent on many factors, including the success of our ability to successfully commercialize XERMELOcommercialization of INPEFA in the United States;States and the amount and timing of payments, if any, under our existing collaboration agreements with Sanofi, Ipsen and other entities;revenues generated from sales of INPEFA; the success of our ongoing preclinicalresearch and clinical development efforts and the ability to obtain necessary regulatory approvals;approvals of the drug candidates which are the subject of such efforts; our success in establishing new collaborations and licenses; the timinglicenses and willingnessour receipt of such new collaborators to commercialize products that would result

in milestone payments andmilestones, royalties and their success inother payments under such efforts;arrangements; and general and industry-specific economic conditions which may affect research, development and developmentcommercialization expenditures.


Future revenues from our commercialization of XERMELO are uncertain because they depend on a number of factors, including market acceptance of XERMELO, the success of our sales, marketing, medical affairs, distribution and other commercialization activities and the cost and availability of reimbursement for XERMELO.
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Future revenues from our existing collaborations are uncertain because they depend, to a large degree, on the achievement of milestones and payment of royalties we earn from any future products developed under the collaborations. Our ability to secure future revenue-generating agreements will depend upon our ability to address the needs of our potential future collaborators and licensees, and to negotiate agreements that we believe are in our long-term best interests.  We may determine, as we have with certain of our drug candidates, including XERMELOINPEFA in the United States and Japan,heart failure, that our interests are better served by retaining rights to our discoveries and advancing our therapeutic programs to a later stage, which could limit our near-term revenues and increase expenses.  Because of these and other factors, our operating results have fluctuated in the past and are likely to do so in the future, and we do not believe that period-to-period comparisons of our operating results are a good indication of our future performance.


Since our inception, we have incurred significant losses and, as of September 30, 2017,March 31, 2024, we had an accumulated deficit of $1.4$1.8 billion. Our losses have resulted principally from costs incurred in research and development, selling, general and administrative costs associated with our operations, and non-cash stock-based compensation expenses associated with stock options and restricted stock units granted to employees and consultants. Research and development expenses consist primarily of salaries and related personnel costs, external research costs related to our nonclinical and clinical efforts, material costs, facility costs, depreciation on property and equipment, and other expenses related to our drug discovery and development programs. Selling, general and administrative expenses consist primarily of salaries and related expenses for executive, sales and marketing, and administrative personnel, professional fees and other corporate expenses, including information technology, facilities costs and general legal activities. We expect to continue to incur significant research and development costs in connection with the continuing research and development of our drug candidates.candidates and significant selling, general and administrative expenses in connection with our commercial launch of INPEFA. As a result, we will need to generate significantly higher revenues to achieve profitability.
Critical Accounting Policies
The preparation of financial statements in conformity with generally accepted accounting principles requires us to make judgments, estimates and assumptions in the preparation of our condensed consolidated financial statements and accompanying notes.  Actual results could differ from those estimates.  We believe there have been no significant changes in our critical accounting policies as discussed in our Annual Report on Form 10-K for the year ended December 31, 2016.2023.
Recent Accounting Pronouncements
See Note 2, Recent Accounting Pronouncements, of the Notes to Consolidated Financial Statements (unaudited), for a discussion of the impact of the new accounting standards on our consolidated financial statements (unaudited).
Results of Operations
 
Revenues

Total revenues and dollar and percentage changes as compared to the corresponding periods in the prior year are as follows (dollar amounts are presented in millions):
  Three Months Ended September 30, Nine Months Ended September 30,
  2017 2016 2017 2016
Total revenues $26.9
 $27.7
 $57.3
 $60.3
Dollar decrease $(0.8)   $(3.0)  
Percentage decrease (3)%   (5)%  

Net product revenue – Net product revenue for the three and nine months ended September 30, 2017 was $5.8 million and $10.4 million, respectively, due to revenues recognized from the sale of XERMELO in the United States and sales of bulk tablets of telotristat ethyl to Ipsen. Product revenues are recorded net of estimated product returns, pricing discounts including rebates offered pursuant to mandatory federal and state government programs and chargebacks,

prompt pay discounts and distribution fees and co-pay assistance. Revenue recognition policies require estimates of the aforementioned sales allowances each period.
Collaborative agreements – Revenue from collaborative agreementsRevenues for the three months ended September 30, 2017 decreased 24% to $21.1 million, and for the nine months ended September 30, 2017 decreased 22% to $46.8March 31, 2024 were approximately $1.1 million primarily due tofrom product revenues recognized as a resultfrom sales of the timing of clinical trial activities under the collaboration and license agreement with Sanofi.
INPEFA following its regulatory approval in May 2023.

Cost of Sales

Cost of sales forduring the three and nine months ended September 30, 2017 was $0.6 millionMarch 31, 2024 consist of third-party manufacturing costs and $1.4 million, respectively.freight associated with sales of INPEFA. Prior to receiving regulatory approval on May 26, 2023, we had completed or begun the manufacturing of certain INPEFA raw materials. These raw materials were either received at “zero-cost” to us in conjunction with a terminated agreement in 2019 or recorded as research and development expense. Based on our expectations for future manufacturing costs, we estimate these amounts totaled approximately $39.0 million. We began capitalizing inventory during the nine months ended September 30, 2017 once the FDA approved XERMELOmanufactured subsequent to regulatory approval of INPEFA as the related costs were expected to be recoverable through the commercialization of the product. Costs incurred priorAt March 31, 2024, substantially all of the “zero-cost” INPEFA raw materials remains available to FDA approval were recorded as research and development expenses in the consolidated statements of comprehensive loss. Cost of sales consists of third-party manufacturing costs, freight and indirect overhead costs associated with sales of XERMELO.us. The pre-commercialization“zero-cost” inventory is expected to be soldconsumed over approximately the next two years. As athree years, which will result cost of sales for the next two years will reflectin a lower average per unit cost of materials. Costmaterials during that period; however, the time period over which this inventory is consumed will depend on a number of factors, including the amount of future INPEFA sales, foruse of this inventory in clinical development or other research activities, production lead times, and/or the three and nine months ended September 30, 2017 includes $0.4 million and $1.0 million, respectively,ability to utilize inventory prior to its expiration date. We estimate our cost of amortizationgoods sold as a percentage of intangible assets relatingnet product revenue will be less than 10% subsequent to XERMELO.the utilization of all of the remaining “zero-cost” inventory.



15

Research and Development Expenses
 
Research and development expenses and dollar and percentage changes as compared to the corresponding periods in the prior year are as follows (dollar amounts are presented in millions):
 Three Months Ended March 31,
 20242023
Total research and development expense$14.4 $12.0 
Dollar increase$2.4  
Percentage increase20 % 
  Three Months Ended September 30, Nine Months Ended September 30,
  2017 2016 2017 2016
Total research and development expense $39.1
 $52.5
 $109.7
 $137.8
Dollar decrease $(13.4)   $(28.1)  
Percentage decrease (26)%   (20)%  
Research and development expenses consist primarily of third-party and other services principally related to nonclinicalpreclinical and clinical development activities, salaries and other personnel-related expenses, facility and equipment costs, stock-based compensation expense, and facility and equipment costs.other costs each of which are described below. 

•Third-party and other services – Third-party and other services for the three months ended September 30, 2017 decreased 31% to $30.5 million, and for the nine months ended September 30, 2017 decreased 28% to $81.9 million as compared to the corresponding periods in 2016, primarily due to decreases in external clinical development costs relating to sotagliflozin. Third-party and other services relate principally to our clinical trial and related development activities, such as nonclinicalpreclinical and clinical studies and contract manufacturing.
Overall, third-party services for the three months ended March 31, 2024 increased 32% to $7.2 million as compared to the corresponding period in 2023 primarily related to increased external research and development costs.


•Personnel – Personnel costs for the three months ended September 30, 2017March 31, 2024 increased 10% to $5.1$4.2 million and for the nine months ended September 30, 2017 increased 24% to $17.2from $4.0 million as compared to the corresponding periodsperiod in 2016, primarily due to increases in personnel.2023. Salaries, bonuses, employee benefits, payroll taxes, recruiting and relocation costs are included in personnel costs.


•Stock-based compensation – Stock-based compensation expenseexpenses for the three months ended September 30, 2017March 31, 2024 increased 28%32% to $1.3 million, and for the nine months ended September 30, 2017 increased 23% to $3.7$1.6 million, as compared to the corresponding periodsperiod in 2016.
2023, due to increased headcount.


•Facilities, equipment, and other – Facilities, equipment, – and other costs relate primarily to rent, insurance, travel and training, and software licensing costs. Facilities, equipment, and equipmentother costs for the three months ended September 30, 2017 decreased 11% to $0.8March 31, 2024 and 2023 were $1.3 million and for the nine months ended September 30, 2017 decreased 8% to $2.3 million, as compared to the corresponding periods in 2016.

Other – Other costs for the three months ended September 30, 2017 decreased 4% to $1.4 million, and for the nine months ended September 30, 2017 increased 20% to $4.5 million, as compared to the corresponding periods in 2016.
respectively.

Increase (Decrease) in Fair Value of Symphony Icon Liability

The fair value of the Symphony Icon purchase liability increased by $2.1 million in the nine months ended September 30, 2017 and decreased by $2.1 million and $0.7 million in the three and nine months ended September 30, 2016, respectively (see Note 6, Arrangements with Symphony Icon, Inc., of the Notes to Consolidated Financial Statements (unaudited), for more information).


Selling, General and Administrative Expenses
 
Selling, general and administrative expenses and dollar and percentage changes as compared to the corresponding periods in the prior year are as follows (dollar amounts are presented in millions):
  Three Months Ended September 30, Nine Months Ended September 30,
  2017 2016 2017 2016
Total selling, general and administrative expense $16.7
 $12.3
 $50.1
 $29.1
Dollar increase $4.5
   $21.0
  
Percentage increase 36%   72%  
Three Months Ended March 31,
 20242023
Total selling, general and administrative expense$32.1 $19.1 
Dollar increase$13.0  
Percentage increase68 %
Selling, general and administrative expenses consist primarily of personnel costs to sell XERMELOsupport the commercialization of INPEFA and to support of our research and development activities, professional and consulting fees, stock-based compensation expense, and facilityfacilities, equipment, and equipment costs.other costs each of which are described further below.

•Personnel – Personnel costs for the three months ended September 30, 2017March 31, 2024 increased 90%113% to $7.1 million, and for the nine months ended September 30, 2017 increased 134% to $22.9$16.4 million, as compared to the corresponding periodsperiod in 2016,2023, primarily due to increaseshigher employee salaries and benefit costs as a result of increased headcount during 2024 in personnel, including increases in sales and marketing personnel, in connectionconjunction with the commercialization of XERMELO.INPEFA. Salaries, bonuses, employee benefits, payroll taxes, recruiting and relocation costs are included in personnel costs.


•Professional and consulting fees – Professional and consulting fees for the three months ended September 30, 2017 decreased 9%March 31, 2024 increased 37% to $5.8 million, and for the nine months ended September 30, 2017 increased 17% to $15.7$9.6 million, as compared to the corresponding periodsperiod in 2016,2023, primarily due to changes inhigher marketing and consulting costsprofessional fees in connectionconjunction with the commercialization of XERMELO.
INPEFA.


•Stock-based compensation – Stock-based compensation expenseexpenses for the three months ended September 30, 2017March 31, 2024 increased 41%22% to $1.2 million, and for the nine months ended September 30, 2017 increased 30% to $3.5$2.7 million, as compared to the corresponding periodsperiod in 2016, primarily2023 due to awards granted to salesincreased headcount.
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•Facilities, equipment, and marketing personnel.

Facilities and equipmentother – Facilities, equipment, and equipmentother costs for the three months ended September 30, 2017 increased 26% to $0.5March 31, 2024 and 2023 were $3.3 million and for$2.2 million, respectively. The increase of $1.1 million in these costs in 2024 was primarily due to travel in conjunction with the nine months ended September 30, 2017 increased 37% to $1.6commercialization of INPEFA.

Interest and Other Expense
Interest and Other Expense. Interest and other expense was $4.9 million as compared to the corresponding periods in 2016.
Other – Other costs forand $1.8 million, respectively, during the three months ended September 30, 2017 increased 136% to $2.1 million,March 31, 2024 and for the nine months ended September 30, 2017 increased 210% to $6.4 million, as compared to the corresponding periods in 2016,2023, primarily due to increasesthe borrowing of additional $50 million in travel and contributions to a foundation supporting carcinoid syndrome patients.
Oxford debt in June 2023.

Interest Expense and InterestIncome and Other, Income, Net
Interest Expense.Income and Other, Net. Interest expense for each ofincome and other, net increased to $1.9 million from $1.0 million during the three months ended September 30, 2017 and 2016 was $1.6 million and forMarch 31, 2024 from the nine months ended September 30, 2017 and 2016 was $4.8 million and $4.9 million, respectively.corresponding period in 2023.


Interest and Other Income, Net. Interest and other income, net for the three months ended September 30, 2017 and 2016 was $0.4 million and $0.6 million, respectively, and for the nine months ended September 30, 2017 and 2016 was $1.4 million and $1.7 million, respectively.


Income Tax Benefit

The income tax benefit for the nine months ended September 30, 2017 was $8.7 million. During the nine months ended September 30, 2017, the Company’s valuation allowance for its deferred tax assets decreased by $8.7 million due to the reclassification of intangible assets relating to XERMELO from indefinite-lived to finite-lived assets, which resulted in the related deferred tax liability now being considered a source of taxable income. The Company recorded a $8.7 million deferred tax benefit with a corresponding reduction in its deferred tax liability in the nine months ended September 30, 2017 as a result of this reclassification.
Consolidated Net Loss and Consolidated Net Loss per Common Share
Consolidated Net Lossloss and Consolidated Net Lossloss per Common Share. Consolidated netNet loss decreased to $30.7was $48.4 million, or $0.20 per share, in the three months ended September 30, 2017 from $36.0March 31, 2024 as compared to a net loss of $31.9 million, or $0.17 per share, in the corresponding period in 2016. Consolidated net loss per common share decreased to $0.29 in the three months ended September 30, 2017 from $0.35 in the corresponding period in 2016. Consolidated net loss decreased to $100.7 million in the nine months ended September 30, 2017 from $109.0 million in the corresponding period in 2016. Consolidated net loss per common share decreased to $0.96 in the nine months ended September 30, 2017 from $1.05 in the corresponding period in 2016.2023.
Our quarterly operating results have fluctuated in the past and are likely to do so in the future, and we believe that quarter-to-quarter comparisons of our operating results are not a good indication of our future performance.

Liquidity and Capital Resources
We have financed our operations from inception primarily through sales of common and preferred stock, contract and milestone payments to uswe received under our collaborations and strategic and other collaborations,licenses, target validation, database subscription and technology license agreements, product sales, government grants and contracts, and financing under debt, lease and lease arrangements. We have also financed certainother project financing arrangements, as well as from commercial sales of our researchapproved drug products.
In March 2022, we entered into a loan and development activitiessecurity agreement with Oxford that provides up to $150 million in borrowing capacity, available in five tranches, under which $100 million has been funded under the first three tranches. The fourth $25 million tranche is available for draw at our agreementsoption upon the achievement of specified INPEFA net sales and until April 25, 2025. The fifth $25 million tranche is available for draw at our option, subject to Oxford’s consent, at any time prior to the expiration of the 36-month interest-only payment period. The loan and security agreement includes a financial covenant relating to INPEFA net sales and a separate financial covenant which requires us to maintain a minimum cash and investments balance of $10 million until the achievement of specified INPEFA net sales. Upon funding of the fourth tranche, the minimum cash and investments balance will increase to $25 million.
In December 2023, we entered into an Open Market Sale AgreementSM with Symphony Icon, Inc. FromJefferies LLC pursuant to which we may offer and sell shares of our inceptioncommon stock having an aggregate sales price of up to $75 million from time to time through September 30, 2017,Jefferies as sales agent. As of March 31, 2024, the full amount is still available for issuance under this agreement.
On March 11, 2024, we hadentered into an agreement with certain accredited investors pursuant to which we agreed to sell 2,304,147 shares of our Series A Convertible Preferred Stock, at a price of $108.50 per share. We received net proceeds of $1.4 billionapproximately $242 million, after deducting placement agent fees and offering expenses from issuancesthe private placement offering. Each share of common and preferred stock will automatically convert into 50 shares of our common stock upon the filing and convertible debt. In addition, fromacceptance of an amendment to our inception through September 30, 2017, we received $809.0 million in cash payments from strategic and other collaborations, target validation, database subscription and technology license agreements, salescertificate of compound libraries and reagents, product sales, and government grants and contracts,incorporation by the Secretary of which $738.2 million had been recognized as revenues through September 30, 2017.State of Delaware increasing the number of authorized shares of our common stock to 450,000,000 shares. For additional information on the private placement offering, please refer to Note 8 of the Notes to the Condensed Consolidated Financial Statements.
As of September 30, 2017,March 31, 2024 and December 31, 2023, we had $196.8$355.6 million and $170.0 million in cash, cash equivalents and investments. As of December 31, 2016, we had $346.5 million in cash, cash equivalents and investments.short-term investments, respectively. We used cash of $151.7$55.1 million infrom operations in the ninethree months ended September 30, 2017. This consisted primarilyMarch 31, 2024, largely reflective of the consolidated net loss for the period of $100.7$48.4 million a net decrease in other operating liabilities net of assets of $54.6 million and the deferred tax benefit of $8.7 million, partially offset bywhich included non-cash charges of $7.2$4.7 million primarily related to stock-based compensation expense, $2.5 million related to depreciation and amortization expense and $2.1 million related to the increase in fair value of the Symphony Icon purchase liability.expense. Investing activities providedused cash of $186.3$110.2 million in the ninethree months ended September 30, 2017,March 31, 2024, primarily due to net maturitiespurchases of investments of $186.5 million.investments. Financing activities provided cash of $2.1$239.4 million, primarily from the issuance of common stocksale of $5.5 million, partially offset by cash used to repurchase common stock2,304,147 shares of $1.7 million and repay debt borrowingsour Series A Convertible Preferred Stock in a private placement at a price of $1.7 million.$108.50 per share.
Texas Institute for Genomic Medicine. In July 2005, we received an award from
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Other commitments. Upon the Texas Enterprise Fundregulatory approval of sotagliflozin for the creationtreatment of type 1 diabetes in a knockout mouse embryonic stem cell library containing 350,000 cell lines for the Texas Institute for Genomic Medicine, or TIGM, using our proprietary gene trapping technology, whichmajor market, we completed in 2007. We also equipped TIGM with the bioinformatics software required for the management and analysis of data relating to the library. The Texas Enterprise Fund made an additional award to the Texas A&M University System for the creation of facilities and infrastructure to house the library.
Under the terms of our award, we were responsible for the creation of a specified number of jobs beginning in 2012, reaching an aggregate of 1,616 new jobs in Texas by December 31, 2016. We maywill be required to repay the statemake certain royalty payments, totaling $4.5 million, in three equal annual installments of $1.5 million. Under our drug discovery alliance with Bristol-Myers Squibb, we will be required to make a portionmilestone payment of $5 million upon dosing of the award if we fail to meet those job obligations.We will receive credits against those job obligations based on funding received by TIGMfirst patient in a Phase 3 clinical trial of LX9211.
For a further discussion of our commitments and certain related parties from sources other than the State of Texas. We will also receive credits against those jobs obligations for any surplus jobs we created. Subject to these credits, the State may require us to repay $2,415 for each job we fell shortcontingencies see Note 6 of the number of jobsNotes to be created beginning in 2013. Our maximum aggregate exposure for such payments is approximately $14.2 million, including $10.3 million through 2017, without giving effect to any jobs created or credits to which we may be entitled.

Facilities. In April 2004, we obtained a $34.0 million mortgage on our facilities in The Woodlands, Texas. The mortgage loan originally had a ten-year term with a 20-year amortization and a fixed interest rate of 8.23%Condensed Consolidated Financial Statements. The mortgage was amended in September 2013 to extend the maturity date from April 2014 to April 2017, with the mortgage loan’s monthly payment amount and fixed interest rate each remaining unchanged.  In April 2017, the mortgage was amended to extend the maturity date to April 2018, with the mortgage loan’s monthly payment amount and fixed interest rate each remaining unchanged. The mortgage had a principal balance outstanding of $14.7 million as of September 30, 2017. The entire principal balance is recorded as current portion of long-term debt in the accompanying consolidated balance sheet as of September 30, 2017 as there is a balloon payment due in April 2018.
In March 2015, our subsidiary Lexicon Pharmaceuticals (New Jersey), Inc. leased a 25,000 square-foot office space in Basking Ridge, New Jersey. The term of the lease extends from June 1, 2015 through December 31, 2022, and provides for escalating yearly base rent payments starting at $482,000 and increasing to $646,000 in the final year of the lease.
Our future capital requirements will be substantial and will depend on many factors, including the market acceptance and commercial success of XERMELOour commercialization of INPEFA in the United StatesStates; the success of our commercial launch of sotagliflozin for patients with type 1 diabetes and CKD, if approved; the success of our ongoing research and development efforts and the revenues we generate from that approved product; Sanofi’s success in obtainingability to obtain necessary regulatory approvals of sotagliflozinthe drug candidates which are the subject of such efforts; our success in type 1 diabetes; the progressestablishing new collaborations and scopelicenses and our receipt of Sanofi’s development activities with respect to sotagliflozin in type 2 diabetes patients; the timing, progress and results of clinical trials of our other drug candidates; the amount and timing of payments, if any, under our existing collaboration agreements with Sanofi, Ipsenmilestones, royalties and other entities;payments under such arrangements; the amount and timing of our research, development and commercialization expenditures; the resources we devote to commercializing, developing and supporting our products and other factors. Our capital requirements will also be affected by any expenditures we make in connection with license agreements and acquisitions of and investments in complementary technologies and businesses.
We expect to continue to devote substantial capital resources to commercialize XERMELO; to support Sanofi’s efforts to seek regulatory approval in the United Statescommercialization of INPEFA for heart failure; the commercial launch of sotagliflozin infor patients with type 1 diabetes; todiabetes and CKD, if approved; the research and development of our clinical development efforts with respect to our other drug candidates; and for other general corporate activities. We believe that our current unrestricted cash and investment balances and cash andas well as future revenues we expect to derive from sales of XERMELO, strategic and other collaborations and other sources will be sufficient to fund our currently planned operations for at least the next 12 months.  During or aftermonths from the date of this period,report. In future periods, if cash on hand or generated by operations is insufficient to satisfy our liquidity requirements, we will need to obtain additional liquidity through future strategic and other collaborations or sell additional equity or debt securities or obtain additional credit arrangements. If we are unable to obtain adequate financing when needed, we may have to delay or reduce the scope of our commercialization efforts or one or more of our clinical trials and other research and development programs. Additional financing may not be available on terms acceptable to us or at all. The sale of additional equity or convertible debt securities may result in additional dilution to our stockholders.
From time to time, our board of directors may authorize us to repurchase shares of our common stock, repurchase, in cash or common stock, our outstanding Notes, or make a cash payment to holders of our Notes to induce a conversion of the notes pursuant to the terms of the Notes, in each case, in privately negotiated transactions, publicly announced programs or otherwise.stock. If and when our board of directors should determine to authorize any such action, it would be on terms and under market conditions that our board of directors determines are in the best interest of us and our stockholders. Any such actions could deplete significant amounts of our cash resources and/or result in additional dilution to our stockholders.


Disclosure about Market Risk
 
We are exposed to limited market and credit risk on our cash equivalents which have maturities of three months or less at the time of purchase. We had approximately $355.6 million in cash and cash equivalents and short-term investments as of March 31, 2024. We maintain a short-term investment portfolio which consists of U.S. Treasury bills and corporate debt securities that mature three to 12 months from the time of purchase, which we believe are subject to limited market and credit risk. We currently do not hedge interest rate exposure or hold any derivative financial instruments in our investment portfolio.
We had approximately $196.8 millionare subject to interest rate sensitivity on our outstanding Oxford Term Loans which bear interest at a floating rate equal to the 1-month CME Term SOFR rate. Interest on the Oxford Term Loans is payable in cash monthly and cash equivalents and short-term investments as of September 30, 2017. We believe that the working capital available to us will be sufficient to fund our operations for at least the next 12 months.term loans are fully matured by March 2027, unless earlier repaid in accordance with their terms.
We have operated primarily in the United States and substantially all sales to date have been made in U.S. dollars. Accordingly, we have not had any material exposure to foreign currency rate fluctuations.

Item 3.Quantitative and Qualitative Disclosures About Market Risk
Item 3.  Quantitative and Qualitative Disclosures About Market Risk
See “Disclosure about Market Risk” under “Item 2. Management’s Discussion and Analysisof Financial Condition and Results of Operations” for quantitative and qualitative disclosures about market risk.


Item 4.Controls and Procedures
Item 4.  Controls and Procedures
Our principal executive officer and principal financial officer have concluded that our disclosure controls and procedures (as defined in rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934) are effective to ensure that the information required to be disclosed by us in the reports we file under the Securities Exchange Act is gathered, analyzed and disclosed with adequate timeliness, accuracy and completeness, based on an evaluation of such controls and procedures as of
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the end of the period covered by this report.

During the nine months ended September 30, 2017, we implemented processes and internal controls to record net product revenue, cost of sales, and inventory as a result of the FDA approval and commercial launch of XERMELO. The implementation of these processes resulted in changes to internal control over financial reporting, which we believe were material. There were no other changes in our internal control over financial reporting during the ninethree months ended September 30, 2017 identified in connection with the evaluation required by Rule 13a-15(d) and 15d-15(d) of the Exchange ActMarch 31, 2024 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.


19

Part II -- Other Information 


Item 1.Legal Proceedings
Item 1.  Legal Proceedings
 
We are from time to time party to claims and legal proceedings that arise in the normal course of our business and that we believe will not have, individually or in the aggregate, a material adverse effect on our results of operations, financial condition or liquidity.



Item 1A.
Item 1A.  Risk Factors

The following risks and uncertainties are important factors that could cause actual results or events to differ materially from those indicated by forward-looking statements. The factors described below are not the only ones we face and additional risks and uncertainties not presently known to us or that we currently deem immaterial also may impair our business operations.
Risks Related to Our Need for Additional FinancingBusiness and Our Financial ResultsIndustry
•We will need additional capital in the future and, if it is unavailable, we will be forced to delay, reduce or eliminate our commercialization efforts or product development programs. If additional capital is not available on reasonable terms, we will be forced to obtain funds, if at all, by entering into financing agreements on unattractive terms.

We have a history of net losses, and we expect to continue to incur net losses and may not achieve or maintain profitability.

Our operating results have been and likely will continue to fluctuate, and we believe that period-to-period comparisons of our operating results are not a good indication of our future performance.

We have substantial indebtedness that may limit cash flow available to invest in the ongoing needs of our business.

We may not have the ability to raise the funds necessary to repurchase the notes evidencing our existing indebtedness upon a fundamental change, and our future debt may contain limitations on our ability to repurchase the notes.

Risks Related to the Commercialization or Development of XERMELO and Our Drug Candidates
We will depend heavily on the commercial success of XERMELOINPEFA in the United States.heart failure. If we do not achieve commercial success with XERMELO,INPEFA, our business will suffer significant adverse consequences.

•We depend heavily on our ability to obtain regulatory approval in the United States for sotagliflozin in patients with type 1 diabetes and CKD. If we fail to obtain such regulatory approval, our stock pricebusiness will likely decline.suffer significant adverse consequences.


•We depend heavily on our ability to successfully complete and obtain positive results from our ongoing PROGRESS Phase 2b clinical trial of LX9211 in DPNP. If we fail to successfully complete and obtain positive results from such clinical trial, or if the progress of such clinical trial is delayed beyond our expected timelines, our business will suffer significant adverse consequences.

•Clinical testing of our drug candidates in humans is an inherently risky and time-consuming process that may fail to demonstrate safety and efficacy, which could result in the delay, limitation or prevention of regulatory approval.


•Our drug candidates are subject to a lengthy and uncertain regulatory process that may not result in the necessary regulatory approvals, which could adversely affect our and our collaborators’ ability to commercialize products.


•The commercial success of XERMELO and any other products that we or our collaborators may develop will depend upon the degree of market acceptance among physicians, patients, health care payers private health insurers and the medical community.


•If we are unable to implement and maintain an effective and specialized sales force, marketing infrastructure and distribution capabilities, we will not be able to successfully commercialize XERMELOany products that we or our drug candidates successfully.collaborators may develop.


•If we are unable to obtainestablish adequate coverage and reimbursement from third-party payorspayers for XERMELO and any other products that we or our collaborators may develop, our revenues and prospects for profitability will suffer.


•We may not be able to manufacture products that we or our collaborators may develop in commercial quantities, which would impair our ability to commercialize such products.

•We and our collaborators are subject to extensive and rigorous ongoing regulation relating to XERMELO and any other approved products.products that we or our collaborators may develop.


•We are subject to certain healthcare laws, regulation and enforcement; our failure to comply with those laws could have a material adverse effect on our results of operations and financial condition.


•Current healthcare laws and regulations and future legislative or regulatory reforms to the healthcare system may negatively affect our revenues and prospects for profitability.


•Our competitors may develop products that make XERMELOimpair the value of any products that we or our collaborators’ other products obsolete.collaborators may develop.


•The outbreak of the novel coronavirus, or COVID-19, had an adverse impact on our business operations and clinical trials and another novel coronavirus could adversely affect our business in the future.

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Risks Related to Our Capital Requirements and Financial Results

•    We will need additional capital in the future and, if it is unavailable, we will be forced to delay, reduce or eliminate our research and development programs. If additional capital is not available on reasonable terms, we will be forced to obtain funds, if at all, by entering into financing agreements on unattractive terms.

•    We may not have sufficient capital to support Phase 3 development of LX9211 in DPNP and do not have sufficient capital to support Phase 3 development of LX9211 in neuropathic pain broadly. If we are unable to establish a strategic collaboration or other arrangement for that purpose, our capital needs will be ablesubstantially higher and we may be unable to manufactureobtain financing sufficient to fund Phase 3 development of LX9211 on acceptable terms, or at all, and may be required to forego or reduce the scope of any such Phase 3 development program.

•We have a history of net losses, and we expect to continue to incur net losses and may not achieve or maintain profitability.

•    Our operating results have fluctuated and likely will continue to fluctuate, and we believe that period-to-period comparisons of our drug candidatesoperating results are not a good indication of our future performance.

•We have substantial indebtedness that may limit cash flow available to invest in commercial quantities, which would prevent us from commercializingthe ongoing needs of our drug candidates.business.


•If we do not effectively manage our affirmative and restrictive covenants under the Oxford Term Loans, our financial condition and results of operations could be adversely affected.


Risks Related to Our Relationships with Third Parties


•    We depend on third-party manufacturers, including sole source suppliers,our ability to manufacture commercial quantities of XERMELO. We may not be able to maintain these relationships and could experience supply disruptions outside of our control.

We rely on a single third-party logistics provider and two independent specialty pharmacies for distribution of XERMELO in the United States, and their failure to distribute XERMELO effectively would adversely affect sales of XERMELO.

We are significantly dependent upon ourestablish collaborations with Ipsen, Sanofi and other pharmaceutical and biotechnology companies.companies for the development and commercialization of our other drug candidates. If we are unable to establish such collaborations, or if pharmaceutical products are not successfully and timely developed and commercialized under oursuch collaborations, our opportunities to generate revenues from milestones and royaltiesour other drug candidates will be greatly reduced.


•Conflicts with our collaborators could jeopardize the success of our collaborative agreements and harm our product development efforts.


•We rely on third parties to carry out drugour preclinical studies and clinical trials, which may harm or delay our research and development activities.efforts.


•We lack the capability to manufacture commercial supplies of INPEFA and any other products which gain regulatory approval and other materials for nonclinical studies, clinical trials or commercial salesour research and relydevelopment activities relating to our drug candidates. Our reliance on third parties to manufacture our drugs and drug candidates which may harm or delay our productresearch, development and commercialization efforts.


Risks Related to Our Intellectual Property

•    If we are unable to adequately protect our intellectual property, third parties may be able to use our products and technologies, which could adversely affect our ability to compete in the market.


•We may be involved in patent litigation and other disputes regarding intellectual property rights and may require licenses from third parties for our planned nonclinical and clinicalresearch, development and commercialization activities. We may not prevail in any such litigation or other dispute or be able to obtain required licenses.


We have not sought patent protection outside of the United States for some of•Data breaches and cyber-attacks could compromise our inventions,intellectual property or other sensitive information and some of our licensed patents only provide coverage in the United States. As a result, our international competitors could be granted foreign patent protection with respectcause significant damage to our discoveries.business, reputational harm and financial loss.


•We may be subject to damages resulting from claims that we, our employees or independent contractors have wrongfully used or disclosed alleged trade secrets of their former employers.


Risks Related to Our Employees Advisors and Facilities Operations

•    If we are unable to manage our growth, our business, financial condition, results of operations and prospects may be adversely affected.

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•The loss of key personnel or the inability to attract and retain additional personnel could impair our ability to operate and expand our operations.


Our collaborations with outside scientists may be subject to restriction and change.

Data breaches and cyber-attacks could compromise our intellectual property or other sensitive information and cause significant damage to our business and reputation.

Facility security breaches may disrupt our operations and harm our operating results.

•Our facilities are located near coastal zones, and the occurrence of a hurricane or other disaster could damage our facilities and equipment, which could harm our operations.operations.


Risks Related to Environmental and Product Liability
•    We have used hazardous chemicals and radioactive and biological materialssubstances in our business. Any claims relating to improper handling, storage or disposal of these materialssubstances could be time consuming and costly.


•Our business has a substantial risk of product liability and we face potential product liability exposure far in excess of our limited insurance coverage.

Risks Related to Our Common Stock
•    Invus, L.P., Invus C.V. and theirits affiliates own a controlling interest in our outstanding common stock and may have interests which conflict with those of our other stockholders.


Conversion of the notes evidencing our current indebtedness may dilute the ownership interest of our existing stockholders, including holders who had previously converted their notes, or may otherwise depress the price of our common stock.

•    Invus has additional rights under ourits stockholders’ agreement with Invus, L.P.relating to the membership of our board of directors and under our certificate of incorporation relating to preemptive and consent rights, which providesprovide Invus with substantial influence over certain significant corporate matters.


•Our stock price may be extremely volatile.


We may engage in future acquisitions, which may be expensive and time consuming and from which we may not realize anticipated benefits.

•Future issuances or sales of our common stock, or the perception that such issuances or sales may occur, may depress our stock price.


•If we are unable to meet Nasdaq continued listing requirements, Nasdaq may take action to delistsecurities or industry analysts do not publish research or publish inaccurate or unfavorable research about our common stock.business, our stock price and trading volume could decline.


For additional discussion of the risks and uncertainties that affect our business, see “Item 1A. Risk Factors” included in our annual report on Form 10-K for the year ended December 31, 20162023 as filed with the Securities and Exchange Commission.

Item 2. Unregistered Sales of Equity Securities and Use of Proceeds
The following table provides information about our purchases of shares of our common stock during the three months ended March 31, 2024:

PeriodTotal Number of Shares PurchasedAverage Price Paid Per ShareTotal Number of Shares Purchased as Part of Publicly Announced Plans or Programs
Maximum Number of Shares that May Yet be Purchased Under the Plans or Programs (3)
January 1-31, 2024—$— ——
February 1-29, 2024660,039(1)$2.62 (2)——
March 1-31, 2024—$— ——

(1)     Represents shares retained by us in satisfaction of the tax withholding obligations of recipients of restricted stock units granted in February 2021, February 2022 and February 2023 under our 2017 Equity Incentive Plan with respect to the vesting of such restricted stock units.

(2)    Represents the market price of our common stock on the date of vesting of such restricted stock units, calculated in accordance with the process for determination of fair market value under our 2017 Equity Incentive Plan.
(3)     In the future, we may grant additional equity securities under our 2017 Equity Incentive Plan for which the recipient's tax withholding obligations with respect to the grant or vesting of such securities may be satisfied by our retention of a portion of such securities. Further, for any such equity securities which are subject to vesting conditions, the number of equity securities which we may retain in satisfaction of the recipient's tax withholding obligations may be dependent on the continued employment of such
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recipient or other performance-based conditions. Accordingly, we cannot predict with any certainty either the total amount of equity securities or the approximate dollar value of such securities that we may purchase in future years.
Item 5. Other Information

Insider Trading Arrangements

During the three months ended March 31, 2024, none of our directors or executive officers adopted or terminated a “Rule 10b5-1 trading arrangement” or “non-Rule 10b5-1 trading arrangement,” as each term is defined in Item 408(a) of Regulation S-K.
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Item 6.
Item 6.  Exhibits


Exhibit No.Description
*†10.1—
Amendment No. 1 to Collaboration and License Agreement, dated July 1, 2017, with Sanofi-Aventis Deutschland GmbH
*31.1—
*31.2—
*32.1—
101.INS—XBRL Instance Document
101.SCH—XBRL Taxonomy Extension Schema Document
101.CAL—XBRL Taxonomy Extension Calculation Linkbase Document
101.DEF—XBRL Taxonomy Extension Definition Linkbase Document
101.LAB—XBRL Taxonomy Extension Label Linkbase Document
101.PRE—XBRL Taxonomy Extension Presentation Linkbase Document
104—
Cover Page Interactive Data File (embedded within the Inline XBRL document)
_____________________
*Filed herewith.
*Filed herewith.
†Confidential treatment has been requested for a portion of this exhibit.  The confidential portions of this exhibit have been omitted and filed separately with the Securities and Exchange Commission.



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Signatures
 

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

Lexicon Pharmaceuticals, Inc.
Date:November 8, 2017May 2, 2024By:/s/ Lonnel Coats
Lonnel Coats
President and Chief Executive Officer

Date:May 2, 2024By:
Date:November 8, 2017By:/s/ Jeffrey L. Wade
Jeffrey L. Wade
Executive Vice President Corporate and Administrative Affairs and Chief Financial Officer




Index to Exhibits

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Exhibit No.Description
*†10.1—Amendment No. 1 to Collaboration and License Agreement, dated July 1, 2017, with Sanofi-Aventis Deutschland GmbH
*31.1—Certification of Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
*31.2—Certification of Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
*32.1—Certification of Principal Executive and Principal Financial Officers Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
101.INS—XBRL Instance Document
101.SCH—XBRL Taxonomy Extension Schema Document
101.CAL—XBRL Taxonomy Extension Calculation Linkbase Document
101.DEF—XBRL Taxonomy Extension Definition Linkbase Document
101.LAB—XBRL Taxonomy Extension Label Linkbase Document
101.PRE—XBRL Taxonomy Extension Presentation Linkbase Document
_____________________
*Filed herewith.
†Confidential treatment has been requested for a portion of this exhibit.  The confidential portions of this exhibit have been omitted and filed separately with the Securities and Exchange Commission.



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