Table of Contents
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549 
FORM 10-Q
QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the quarterly period ended June 30, 2021March 31, 2022
OR
TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the transition period from                     to                     .
Commission File Number: 001-36042
 PRECIGEN, INC.
(Exact name of registrant as specified in its charter)
Virginia 26-0084895
(State or other jurisdiction of
incorporation or organization)
 (I.R.S. Employer
Identification Number)
20374 Seneca Meadows Parkway 
Germantown,Maryland 20876
(Address of principal executive offices) (Zip Code)
(301) 556-9900
(Registrant's telephone number, including area code) 
N/A
(Former name, former address and former fiscal year, if changed since last report) 
Securities registered pursuant to Section 12(b) of the Exchange Act:
Title of each class Trading Symbol(s) Name of each exchange on which registered
Common Stock, no par value PGEN Nasdaq Global Select Market
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes      No  
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).    Yes      No  
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer  Accelerated filer 
Non-accelerated filer  Smaller reporting company 
Emerging growth company
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.    
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).    Yes      No  
As of July 31, 2021, 206,643,428April 30, 2022, 207,693,277 shares of common stock, no par value per share, were issued and outstanding.


Table of Contents
PRECIGEN, INC.
FORM 10-Q
TABLE OF CONTENTS
 
Item No.Item No. PageItem No. Page
1.1.1.
2.2.2.
3.3.3.
4.4.4.
1.1.1.
1A.1A.1A.
2.2.2.
3.3.3.
4.4.4.
5.5.5.
6.6.6.
Intrexon®, Trans Ova Genetics®, Progentus®, UltraCAR-T®, RheoSwitch®, UltraVector®, RTS®, and RheoSwitch Therapeutic System® are our and/or our affiliates' registered trademarks in the United States and ActoBiotics™, GenVec™, Precigen™, AdenoVerse™, ActoBio Therapeutics™, UltraPorator™, AttSite™, and Precigen Therapeutics™ are our and/or our affiliates' common law trademarks in the United States. This Quarterly Report on Form 10-Q, or Quarterly Report, and the information incorporated herein by reference contain references to trademarks, service marks, and trade names owned by us or other companies. Solely for convenience, trademarks, service marks, and trade names referred to in this Quarterly Report and the information incorporated herein, including logos, artwork, and other visual displays, may appear without the ® or ™ symbols, but such references are not intended to indicate, in any way, that we will not assert, to the fullest extent under applicable law, our rights or the rights of the applicable licensor to these trademarks, service marks, and trade names. We do not intend our use or display of other companies' trade names, service marks, or trademarks to imply a relationship with, or endorsement or sponsorship of us by, any other companies. Other trademarks, trade names, and service marks appearing in this Quarterly Report are the property of their respective owners. Unless the context requires otherwise, references in this Quarterly Report to "Precigen", "we", "us", and "our" refer to Precigen, Inc.
2

Table of Contents

Special Note Regarding Forward-Looking Statements
This Quarterly Report contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, which statements involve substantial risks and uncertainties. All statements, other than statements of historical facts, included in this Quarterly Report, including statements regarding our strategy; future events, including their outcome or timing; future operations; future financial position; future revenue; projected costs; prospects; plans; objectives of management; and expected market growth, are forward-looking statements. The words "aim", "anticipate", "assume", "believe", "continue", "could", "due", "estimate", "expect", "intend", "may", "plan", "positioned", "potential", "predict", "project", "seek", "should", "target", "will", "would", and the negatives of these terms or similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. These statements may relate to, among other things: (i) the impact of the COVID-19 pandemic on our clinical trials, businesses, operating results, cash flows, and/or financial condition; (ii) the timeliness of regulatory approvals; (iii) our strategy and overall approach to our business model, our efforts to realign our business, and our ability to exercise more control and ownership over the development process and commercialization path; (iv) our ability to successfully enter new markets or develop additional product candidates, including the expected timing and results of investigational studies and preclinical and clinical trials, including any delays or potential delays as a result of the COVID-19 pandemic, whether with our collaborators or independently; (v) our ability to consistently manufacture our product candidates on a timely basis or to establish agreements with third-party manufacturers; (vi) our ability to successfully enter into optimal strategic relationships with our subsidiaries and operating companies that we may form in the future; (vii) our ability to hold or generate significant operating capital, including through partnering, asset sales, and operating cost reductions; (viii) actual or anticipated variations in our operating results; (ix) actual or anticipated fluctuations in competitors' or collaborators' operating results or changes in their respective growth rates; (x) our cash position; (xi) market conditions in our industry; (xii) the volatility of our stock price; (xiii) the ability, and the ability of our collaborators, to protect our intellectual property and other proprietary rights and technologies; (xiv) our ability, and the ability of our collaborators, to adapt to changes in laws or regulations or policies, including federal, state, and local government responses to the COVID-19 pandemic; (xv) outcomes of pending and future litigation; (xvi) the rate and degree of market acceptance of any products developed by us, our subsidiaries, collaborations, or joint ventures, or JVs, and competition from existing technologies and products or new technologies and products that may emerge; (xvii) our ability to retain and recruit key personnel; (xviii) expectations related to the use of proceeds from public offerings and other financing efforts; (xix) estimates regarding expenses, future revenue, capital requirements, and needs for additional financing; and (xx) the effects, duration, and severity of the ongoing COVID-19 pandemic and the actions we and others have taken or may take in response.
Forward-looking statements are based on our beliefs, assumptions, and expectations of our future performance, and may also concern our expectations relating to our subsidiaries and other affiliates. We caution you that the foregoing list may not contain all of the forward-looking statements made in this Quarterly Report.
We may not actually achieve the plans, intentions, or expectations disclosed in our forward-looking statements, and you should not place undue reliance on our forward-looking statements. Actual results or events could differ materially from the plans, intentions, and expectations disclosed in the forward-looking statements we make. We have included important factors in the cautionary statements included in this Quarterly Report, particularly in Part II, Item 1A, "Risk Factors," that could cause actual results or events to differ materially from the forward-looking statements that we make. Our forward-looking statements do not reflect the potential impact of any future acquisitions, mergers, dispositions, JVs, or investments that we may make.
You should read this Quarterly Report, the documents that we reference in this Quarterly Report, our Annual Report on Form 10-K for the year ended December 31, 2020,2021, the other reports we have filed with the Securities and Exchange Commission, or SEC, and the documents that we have filed as exhibits to our filings with the SEC completely and with the understanding that our actual future results may be materially different from what we expect. We do not assume any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.
3

Table of Contents
PART I. FINANCIAL INFORMATION
Item 1. Condensed Consolidated Financial Statements
Precigen, Inc. and Subsidiaries
Condensed Consolidated Balance Sheets
(Unaudited)
(Amounts in thousands, except share data)(Amounts in thousands, except share data)June 30,
2021
December 31,
2020
(Amounts in thousands, except share data)March 31,
2022
December 31,
2021
AssetsAssetsAssets
Current assetsCurrent assetsCurrent assets
Cash and cash equivalentsCash and cash equivalents$36,412 $51,792 Cash and cash equivalents$40,321 $42,920 
Short-term investmentsShort-term investments78,694 48,325 Short-term investments71,821 72,240 
ReceivablesReceivablesReceivables
Trade, less allowance for credit losses of $4,986 and $4,825 as of June 30, 2021 and December 31, 2020, respectively26,016 16,487 
Related parties, less allowance for credit losses of $1,509 as of June 30, 2021 and December 31, 202022 19 
Notes3,689 
Trade, less allowance for credit losses of $4,631 and $4,288 as of March 31, 2022 and December 31, 2021, respectivelyTrade, less allowance for credit losses of $4,631 and $4,288 as of March 31, 2022 and December 31, 2021, respectively24,308 20,832 
Related parties, less allowance for credit losses of $1,509 as of March 31, 2022 and December 31, 2021Related parties, less allowance for credit losses of $1,509 as of March 31, 2022 and December 31, 202115 73 
OtherOther633 232 Other543 566 
InventoryInventory11,413 11,359 Inventory12,730 13,261 
Prepaid expenses and otherPrepaid expenses and other3,484 7,192 Prepaid expenses and other5,199 6,736 
Current assets held for sale or abandonment11 9,853 
Total current assetsTotal current assets156,685 148,948 Total current assets154,937 156,628 
Long-term investmentsLong-term investments85,269 Long-term investments29,914 48,562 
Property, plant and equipment, netProperty, plant and equipment, net32,745 34,924 Property, plant and equipment, net33,583 34,315 
Intangible assets, netIntangible assets, net59,942 65,396 Intangible assets, net51,427 54,115 
GoodwillGoodwill54,273 54,363 Goodwill53,613 54,148 
Right-of-use assetsRight-of-use assets12,327 9,353 Right-of-use assets10,963 10,900 
Other assetsOther assets1,332 1,603 Other assets1,131 1,188 
Total assetsTotal assets$402,573 $314,587 Total assets$335,568 $359,856 
The accompanying notes are an integral part of these condensed consolidated financial statements.
4

Table of Contents
Precigen, Inc. and Subsidiaries
Condensed Consolidated Balance Sheets
(Unaudited) 
(Amounts in thousands, except share data)(Amounts in thousands, except share data)June 30,
2021
December 31,
2020
(Amounts in thousands, except share data)March 31,
2022
December 31,
2021
Liabilities and Shareholders' EquityLiabilities and Shareholders' EquityLiabilities and Shareholders' Equity
Current liabilitiesCurrent liabilitiesCurrent liabilities
Accounts payableAccounts payable$4,937 $4,598 Accounts payable$4,415 $5,405 
Accrued compensation and benefitsAccrued compensation and benefits7,766 8,097 Accrued compensation and benefits6,052 11,223 
Other accrued liabilitiesOther accrued liabilities10,473 9,549 Other accrued liabilities10,494 11,595 
Deferred revenueDeferred revenue3,276 2,800 Deferred revenue2,669 4,442 
Current portion of long-term debtCurrent portion of long-term debt356 360 Current portion of long-term debt355 402 
Current portion of lease liabilitiesCurrent portion of lease liabilities1,937 2,657 Current portion of lease liabilities1,590 1,551 
Related party payablesRelated party payables22 19 Related party payables26 27 
Current liabilities held for sale or abandonment102 14,047 
Total current liabilitiesTotal current liabilities28,869 42,127 Total current liabilities25,601 34,645 
Long-term debt, net of current portionLong-term debt, net of current portion176,922 171,522 Long-term debt, net of current portion201,112 182,749 
Deferred revenue, net of current portion, including $21,205 from related parties as of June 30, 2021 and December 31, 202023,023 23,023 
Deferred revenue, net of current portion, including $21,205 from related parties as of March 31, 2022 and December 31, 2021Deferred revenue, net of current portion, including $21,205 from related parties as of March 31, 2022 and December 31, 202123,023 23,023 
Lease liabilities, net of current portionLease liabilities, net of current portion11,821 7,744 Lease liabilities, net of current portion9,508 9,502 
Deferred tax liabilitiesDeferred tax liabilities2,692 2,897 Deferred tax liabilities2,438 2,539 
Other long-term liabilitiesOther long-term liabilities50 100 Other long-term liabilities50 50 
Total liabilitiesTotal liabilities243,377 247,413 Total liabilities261,732 252,508 
Commitments and contingencies (Note 16)Commitments and contingencies (Note 16)00Commitments and contingencies (Note 16)00
Shareholders' equityShareholders' equityShareholders' equity
Common stock, 0 par value, 400,000,000 shares authorized as of June 30, 2021 and December 31, 2020; 206,580,928 shares and 187,663,207 shares issued and outstanding as of June 30, 2021 and December 31, 2020, respectively
Common stock, no par value, 400,000,000 shares authorized as of March 31, 2022 and December 31, 2021; 207,693,277 shares and 206,739,874 shares issued and outstanding as of March 31, 2022 and December 31, 2021, respectivelyCommon stock, no par value, 400,000,000 shares authorized as of March 31, 2022 and December 31, 2021; 207,693,277 shares and 206,739,874 shares issued and outstanding as of March 31, 2022 and December 31, 2021, respectively— — 
Additional paid-in capitalAdditional paid-in capital2,017,413 1,886,567 Additional paid-in capital1,991,670 2,022,701 
Accumulated deficitAccumulated deficit(1,860,758)(1,823,390)Accumulated deficit(1,916,135)(1,915,556)
Accumulated other comprehensive income2,541 3,997 
Accumulated other comprehensive (loss) incomeAccumulated other comprehensive (loss) income(1,699)203 
Total shareholders' equityTotal shareholders' equity159,196 67,174 Total shareholders' equity73,836 107,348 
Total liabilities and shareholders' equityTotal liabilities and shareholders' equity$402,573 $314,587 Total liabilities and shareholders' equity$335,568 $359,856 
The accompanying notes are an integral part of these condensed consolidated financial statements.
5

Table of Contents
Precigen, Inc. and Subsidiaries
Condensed Consolidated Statements of Operations
(Unaudited)

(Amounts in thousands, except share and per share data)(Amounts in thousands, except share and per share data)Three Months Ended 
 June 30,
Six Months Ended 
 June 30,
(Amounts in thousands, except share and per share data)Three Months Ended 
 March 31,
202120202021202020222021
RevenuesRevenuesRevenues
Collaboration and licensing revenues, including $0 and $32 from related parties during the three months ended June 30, 2021 and 2020, respectively, and $0 and $230 during the six months ended June 30, 2021 and 2020, respectively$301 $4,315 $367 $15,036 
Collaboration and licensing revenuesCollaboration and licensing revenues$— $66 
Product revenuesProduct revenues8,335 8,540 14,716 13,501 Product revenues8,724 6,381 
Service revenuesService revenues24,803 17,381 42,734 31,327 Service revenues23,209 17,931 
Other revenuesOther revenues141 188 274 398 Other revenues88 133 
Total revenuesTotal revenues33,580 30,424 58,091 60,262 Total revenues32,021 24,511 
Operating ExpensesOperating ExpensesOperating Expenses
Cost of productsCost of products6,135 8,141 11,709 14,230 Cost of products7,510 5,574 
Cost of servicesCost of services8,898 6,770 16,300 14,306 Cost of services9,589 7,402 
Research and developmentResearch and development13,681 9,474 24,202 20,801 Research and development12,760 10,521 
Selling, general and administrativeSelling, general and administrative19,997 17,869 38,699 39,355 Selling, general and administrative19,576 18,702 
Impairment of goodwillImpairment of goodwill482 — 
Impairment of other noncurrent assets543 543 
Total operating expensesTotal operating expenses49,254 42,254 91,453 88,692 Total operating expenses49,917 42,199 
Operating lossOperating loss(15,674)(11,830)(33,362)(28,430)Operating loss(17,896)(17,688)
Other Expense, NetOther Expense, NetOther Expense, Net
Interest expenseInterest expense(4,667)(4,592)(9,206)(9,184)Interest expense(2,069)(4,539)
Interest incomeInterest income410 773 802 1,446 Interest income434 392 
Other income (expense), netOther income (expense), net(192)71 (250)135 Other income (expense), net223 (58)
Total other expense, netTotal other expense, net(4,449)(3,748)(8,654)(7,603)Total other expense, net(1,412)(4,205)
Equity in net loss of affiliatesEquity in net loss of affiliates(251)(3)(602)Equity in net loss of affiliates(1)(3)
Loss from continuing operations before income taxesLoss from continuing operations before income taxes(20,123)(15,829)(42,019)(36,635)Loss from continuing operations before income taxes(19,309)(21,896)
Income tax benefitIncome tax benefit60 120 112 80 Income tax benefit58 52 
Loss from continuing operationsLoss from continuing operations(20,063)(15,709)(41,907)(36,555)Loss from continuing operations(19,251)(21,844)
Income (loss) from discontinued operations, net of income taxes13 (27,645)4,539 (62,797)
Income from discontinued operations, net of income taxesIncome from discontinued operations, net of income taxes— 4,526 
Net lossNet loss$(20,050)$(43,354)$(37,368)$(99,352)Net loss$(19,251)$(17,318)
Net Loss per ShareNet Loss per ShareNet Loss per Share
Net loss from continuing operations per share, basic and dilutedNet loss from continuing operations per share, basic and diluted$(0.10)$(0.10)$(0.21)$(0.23)Net loss from continuing operations per share, basic and diluted$(0.10)$(0.11)
Net income (loss) from discontinued operations per share, basic and diluted(0.16)0.02 (0.38)
Net income from discontinued operations per share, basic and dilutedNet income from discontinued operations per share, basic and diluted— 0.02 
Net loss per share, basic and dilutedNet loss per share, basic and diluted$(0.10)$(0.26)$(0.19)$(0.61)Net loss per share, basic and diluted$(0.10)$(0.09)
Weighted average shares outstanding, basic and dilutedWeighted average shares outstanding, basic and diluted199,021,587 164,065,087 196,275,820 162,201,915 Weighted average shares outstanding, basic and diluted199,629,218 193,499,546 
The accompanying notes are an integral part of these condensed consolidated financial statements.
6

Table of Contents
Precigen, Inc. and Subsidiaries
Condensed Consolidated Statements of Comprehensive Loss
(Unaudited)
 
 Three Months Ended 
 June 30,
Six Months Ended 
 June 30,
(Amounts in thousands)2021202020212020
Net loss$(20,050)$(43,354)$(37,368)$(99,352)
Other comprehensive income (loss):
Unrealized gain (loss) on investments(37)(300)(85)272 
Income (loss) on foreign currency translation adjustments832 1,004 (1,371)(411)
Release of cumulative foreign currency translation adjustments to loss from discontinued operations26,957 
Comprehensive loss$(19,255)$(42,650)$(38,824)$(72,534)
 Three Months Ended 
 March 31,
(Amounts in thousands)20222021
Net loss$(19,251)$(17,318)
Other comprehensive loss:
Unrealized loss on investments(802)(48)
Loss on foreign currency translation adjustments(1,100)(2,203)
Comprehensive loss$(21,153)$(19,569)
The accompanying notes are an integral part of these condensed consolidated financial statements.
7

Table of Contents
Precigen, Inc. and Subsidiaries
Condensed Consolidated Statements of Shareholders' Equity
(Unaudited)
 
(Amounts in thousands, except share data)(Amounts in thousands, except share data)Common StockAdditional
Paid-in
Capital
Accumulated
Other
Comprehensive
Income
Accumulated
Deficit
Total
Shareholders'
Equity
(Amounts in thousands, except share data)Common StockAdditional
Paid-in
Capital
Accumulated
Other
Comprehensive
Income (Loss)
Accumulated
Deficit
Total
Shareholders'
Equity
SharesAmount(Amounts in thousands, except share data)SharesAmountAdditional
Paid-in
Capital
Balances at March 31, 2021206,414,135 $$2,013,757 $1,746 $(1,840,708)$174,795 
Balances at December 31, 2021Balances at December 31, 2021206,739,874 $— $2,022,701 $203 $(1,915,556)$107,348 
Cumulative effect of adoption of ASU 2020-06Cumulative effect of adoption of ASU 2020-06— — (36,868)— 18,672 (18,196)
Stock-based compensation expenseStock-based compensation expense— — 3,557 — — 3,557 Stock-based compensation expense— — 3,562 — — 3,562 
Shares issued upon vesting of restricted stock units and for exercises of stock optionsShares issued upon vesting of restricted stock units and for exercises of stock options166,793 — 99 — — 99 Shares issued upon vesting of restricted stock units and for exercises of stock options354,089 — — — 
Shares issued for accrued compensationShares issued for accrued compensation315,327 — 1,698 — — 1,698 
Shares issued as payment for servicesShares issued as payment for services283,987 — 576 — — 576 
Net lossNet loss— — — — (20,050)(20,050)Net loss— — — — (19,251)(19,251)
Other comprehensive income— — — 795 — 795 
Balances at June 30, 2021206,580,928 $$2,017,413 $2,541 $(1,860,758)$159,196 
Other comprehensive lossOther comprehensive loss— — — (1,902)— (1,902)
Balances at March 31, 2022Balances at March 31, 2022207,693,277 $— $1,991,670 $(1,699)$(1,916,135)$73,836 
(Amounts in thousands, except share data)(Amounts in thousands, except share data)Common StockAdditional
Paid-in
Capital
Accumulated
Other
Comprehensive
Loss
Accumulated
Deficit
Total
Shareholders'
Equity
(Amounts in thousands, except share data)Common StockAdditional
Paid-in
Capital
Accumulated
Other
Comprehensive
Income (Loss)
Accumulated
Deficit
Total
Shareholders'
Equity
SharesAmount(Amounts in thousands, except share data)SharesAmountAdditional
Paid-in
Capital
Balances at March 31, 2020170,656,834 $$1,797,450 $(1,354)$(1,708,867)$87,229 
Balances at December 31, 2020Balances at December 31, 2020187,663,207 $— $1,886,567 $3,997 $(1,823,390)$67,174 
Stock-based compensation expenseStock-based compensation expense— — 4,897 — — 4,897 Stock-based compensation expense— — 5,415 — — 5,415 
Shares issued upon vesting of restricted stock units and for exercises of stock optionsShares issued upon vesting of restricted stock units and for exercises of stock options171,682 — 66 — — 66 Shares issued upon vesting of restricted stock units and for exercises of stock options1,426,157 — 153 — — 153 
Shares issued for accrued compensation1,457,416 — — — — 
Shares issued as payment for servicesShares issued as payment for services74,771 — 577 — — 577 
Shares issued in public offerings, net of issuance costsShares issued in public offerings, net of issuance costs17,250,000 — 121,045 — — 121,045 
Net lossNet loss— — — — (43,354)(43,354)Net loss— — — — (17,318)(17,318)
Other comprehensive income— — — 704 — 704 
Balances at June 30, 2020172,285,932 $$1,802,413 $(650)$(1,752,221)$49,542 
Other comprehensive lossOther comprehensive loss— — — (2,251)— (2,251)
Balances at March 31, 2021Balances at March 31, 2021206,414,135 $— $2,013,757 $1,746 $(1,840,708)$174,795 
The accompanying notes are an integral part of these condensed consolidated financial statements.

8

Table of Contents
Precigen, Inc. and Subsidiaries
Condensed Consolidated Statements of Shareholders' Equity
(Unaudited)
(Amounts in thousands, except share data)Common StockAdditional
Paid-in
Capital
Accumulated
Other
Comprehensive
Income
Accumulated
Deficit
Total
Shareholders'
Equity
SharesAmount
Balances at December 31, 2020187,663,207 $$1,886,567 $3,997 $(1,823,390)$67,174 
Stock-based compensation expense— — 8,972 — — 8,972 
Shares issued upon vesting of restricted stock units and for exercises of stock options1,592,950 — 252 — — 252 
Shares issued as payment for services74,771 — 577 — — 577 
Shares issued in public offering, net of issuance costs17,250,000 — 121,045 — — 121,045 
Net loss— — — — (37,368)(37,368)
Other comprehensive loss— — — (1,456)— (1,456)
Balances at June 30, 2021206,580,928 $$2,017,413 $2,541 $(1,860,758)$159,196 
(Amounts in thousands, except share data)Common StockAdditional
Paid-in
Capital
Accumulated
Other
Comprehensive
Loss
Accumulated
Deficit
Total
Shareholders'
Equity
SharesAmount
Balances at December 31, 2019163,274,880 $$1,752,048 $(27,468)$(1,652,869)$71,711 
Stock-based compensation expense— — 9,269 — — 9,269 
Shares issued upon vesting of restricted stock units and for exercises of stock options840,468 — 66 — — 66 
Shares issued for accrued compensation1,805,405 — 5,100 — — 5,100 
Shares issued as payment for services392,483 — 930 — — 930 
Shares issued in private placement5,972,696 — 35,000 — — 35,000 
Net loss— — — — (99,352)(99,352)
Release of cumulative translation adjustments to loss from discontinued operations— — — 26,957 — 26,957 
Other comprehensive loss— — — (139)— (139)
Balances at June 30, 2020172,285,932 $$1,802,413 $(650)$(1,752,221)$49,542 
The accompanying notes are an integral part of these condensed consolidated financial statements.

9

Table of Contents
Precigen, Inc. and Subsidiaries
Condensed Consolidated Statements of Cash Flows
(Unaudited)
Six Months Ended 
 June 30,
Three Months Ended 
 March 31,
(Amounts in thousands)(Amounts in thousands)20212020(Amounts in thousands)20222021
Cash flows from operating activitiesCash flows from operating activitiesCash flows from operating activities
Net lossNet loss$(37,368)$(99,352)Net loss$(19,251)$(17,318)
Adjustments to reconcile net loss to net cash used in operating activities:Adjustments to reconcile net loss to net cash used in operating activities:Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortizationDepreciation and amortization7,043 9,593 Depreciation and amortization3,292 3,523 
(Gain) loss on disposals of assets, net(229)991 
Loss (gain) on disposals of assets, netLoss (gain) on disposals of assets, net125 (343)
Impairment of goodwillImpairment of goodwill9,635 Impairment of goodwill482 — 
Impairment of other noncurrent assets543 12,406 
Gain on sale of discontinued operations(672)
Loss on release of cumulative foreign currency translation adjustments to loss from discontinued operations26,957 
Unrealized depreciation on equity securities106 
Amortization of premiums (discounts) on investments, net498 (500)
Amortization of premiums on investments, netAmortization of premiums on investments, net265 57 
Equity in net loss of affiliatesEquity in net loss of affiliates640 Equity in net loss of affiliates
Stock-based compensation expenseStock-based compensation expense8,972 9,269 Stock-based compensation expense3,562 5,415 
Shares issued as payment for servicesShares issued as payment for services577 930 Shares issued as payment for services576 577 
Provision for credit lossesProvision for credit losses645 679 Provision for credit losses334 162 
Accretion of debt discount and amortization of deferred financing costsAccretion of debt discount and amortization of deferred financing costs5,630 5,101 Accretion of debt discount and amortization of deferred financing costs284 2,751 
Deferred income taxesDeferred income taxes(119)(136)Deferred income taxes(58)(56)
Noncash gain on termination of operating leasesNoncash gain on termination of operating leases— (4,602)
Other noncash itemsOther noncash items(4,601)(112)Other noncash items— 
Changes in operating assets and liabilities:Changes in operating assets and liabilities:Changes in operating assets and liabilities:
Receivables:Receivables:Receivables:
TradeTrade(10,581)(3,679)Trade(3,696)(4,949)
Related partiesRelated parties(3)(17)Related parties58 
OtherOther(403)1,725 Other21 (279)
InventoryInventory(54)3,125 Inventory531 721 
Prepaid expenses and otherPrepaid expenses and other3,794 3,261 Prepaid expenses and other1,571 844 
Other assetsOther assets205 Other assets42 95 
Accounts payableAccounts payable522 (1,955)Accounts payable(588)(189)
Accrued compensation and benefitsAccrued compensation and benefits(627)(1,440)Accrued compensation and benefits(3,462)(1,893)
Other accrued liabilitiesOther accrued liabilities813 (3,034)Other accrued liabilities(1,086)(2,216)
Deferred revenueDeferred revenue482 (15,007)Deferred revenue(1,767)1,054 
Lease liabilitiesLease liabilities145 (188)Lease liabilities(18)218 
Related party payablesRelated party payables123 Related party payables(1)33 
Other long-term liabilities(50)
Net cash used in operating activitiesNet cash used in operating activities(24,160)(41,548)Net cash used in operating activities(18,783)(16,384)
The accompanying notes are an integral part of these condensed consolidated financial statements.
109

Table of Contents
Precigen, Inc. and Subsidiaries
Condensed Consolidated Statements of Cash Flows
(Unaudited)

Six Months Ended 
 June 30,
Three Months Ended 
 March 31,
(Amounts in thousands)(Amounts in thousands)20212020(Amounts in thousands)20222021
Cash flows from investing activitiesCash flows from investing activitiesCash flows from investing activities
Purchases of investmentsPurchases of investments$(174,221)$(133,260)Purchases of investments$— $(174,221)
Sales and maturities of investmentsSales and maturities of investments58,000 57,000 Sales and maturities of investments18,000 40,500 
Purchases of property, plant and equipmentPurchases of property, plant and equipment(2,208)(5,034)Purchases of property, plant and equipment(1,579)(1,014)
Proceeds from sale of assetsProceeds from sale of assets2,258 1,526 Proceeds from sale of assets147 1,944 
Proceeds from sale of discontinued operations, net of cash sold64,240 
Proceeds from repayment of notes receivableProceeds from repayment of notes receivable3,689 2,942 Proceeds from repayment of notes receivable— 3,689 
Net cash used in investing activities(112,482)(12,586)
Net cash provided by (used in) investing activitiesNet cash provided by (used in) investing activities16,568 (129,102)
Cash flows from financing activitiesCash flows from financing activitiesCash flows from financing activities
Proceeds from issuance of shares, net of issuance costsProceeds from issuance of shares, net of issuance costs121,045 35,000 Proceeds from issuance of shares, net of issuance costs— 121,045 
Advances from lines of credit10,005 
Repayments of advances from lines of credit(11,927)
Payments of long-term debtPayments of long-term debt(234)(253)Payments of long-term debt(164)(116)
Proceeds from stock option exercisesProceeds from stock option exercises252 66 Proceeds from stock option exercises111 
Net cash provided by financing activities121,063 32,891 
Net cash (used in) provided by financing activitiesNet cash (used in) provided by financing activities(163)121,040 
Effect of exchange rate changes on cash, cash equivalents, and restricted cashEffect of exchange rate changes on cash, cash equivalents, and restricted cash184 (59)Effect of exchange rate changes on cash, cash equivalents, and restricted cash(230)(11)
Net decrease in cash, cash equivalents, and restricted cashNet decrease in cash, cash equivalents, and restricted cash(15,395)(21,302)Net decrease in cash, cash equivalents, and restricted cash(2,608)(24,457)
Cash, cash equivalents, and restricted cashCash, cash equivalents, and restricted cashCash, cash equivalents, and restricted cash
Beginning of periodBeginning of period52,250 68,434 Beginning of period43,343 52,250 
End of periodEnd of period$36,855 $47,132 End of period$40,735 $27,793 
Supplemental disclosure of cash flow informationSupplemental disclosure of cash flow informationSupplemental disclosure of cash flow information
Cash paid during the period for interestCash paid during the period for interest$3,578 $3,612 Cash paid during the period for interest$3,535 $3,539 
Cash paid during the period for income taxesCash paid during the period for income taxes40 Cash paid during the period for income taxes— 
Significant noncash activitiesSignificant noncash activitiesSignificant noncash activities
Accrued compensation paid in equity awardsAccrued compensation paid in equity awards$$5,100 Accrued compensation paid in equity awards$1,698 $— 
Purchases of property and equipment included in accounts payable and other accrued liabilitiesPurchases of property and equipment included in accounts payable and other accrued liabilities201 259 Purchases of property and equipment included in accounts payable and other accrued liabilities251 255 
Proceeds from sale of assets included in accounts receivableProceeds from sale of assets included in accounts receivable99 Proceeds from sale of assets included in accounts receivable132 23 
The following table provides a reconciliation of the cash, cash equivalents, and restricted cash balances as of June 30, 2021March 31, 2022 and December 31, 20202021 as shown above:
June 30,
2021
December 31,
2020
March 31,
2022
December 31,
2021
Cash and cash equivalentsCash and cash equivalents$36,412 $51,792 Cash and cash equivalents$40,321 $42,920 
Restricted cash included in other assetsRestricted cash included in other assets443 458 Restricted cash included in other assets414 423 
Cash, cash equivalents, and restricted cashCash, cash equivalents, and restricted cash$36,855 $52,250 Cash, cash equivalents, and restricted cash$40,735 $43,343 
The accompanying notes are an integral part of these condensed consolidated financial statements.
1110

Table of Contents
Precigen, Inc. and Subsidiaries
Notes to the Condensed Consolidated Financial Statements
(Unaudited)
(Amounts in thousands, except share and per share data)
1. Organization
Precigen, Inc. ("Precigen"), a Virginia corporation, is a synthetic biology company with an increasing focus on its discovery and clinical stage activities to advance the next generation of gene and cellular therapies to target the most urgent and intractable challenges in immuno-oncology, autoimmune disorders, and infectious diseases. Precigen operates through the following subsidiaries:
PGEN Therapeutics, Inc. ("PGEN Therapeutics") is a dedicated discovery and clinical stage biopharmaceutical company advancing the next generation of gene and cell therapies using precision technology to target urgent and intractable diseases in immuno-oncology, autoimmune disorders, and infectious diseases. PGEN Therapeutics is a wholly owned subsidiary of Precigen with primary operations in Maryland.
Precigen ActoBio, Inc. ("ActoBio") is pioneering a proprietary class of microbe-based biopharmaceuticals that enable expression and local delivery of disease-modifying therapeutics and is a wholly owned subsidiary of Precigen with primary operations in Belgium.
Exemplar Genetics, LLC, doing business as Precigen Exemplar ("Exemplar"), is committed to enabling the study of life-threatening human diseases through the development of MiniSwine Yucatan miniature pig research models and services, as well as enabling the production of cells and organs in its genetically engineered swine for regenerative medicine applications and is a wholly owned subsidiary of Precigen with primary operations in Iowa.
Trans Ova Genetics, L.C., including its wholly owned subsidiary Progentus, L.C., are providers of reproductive technologies, including services and products sold to cattle breeders and other producers and are hereinafter collectively referred to as "Trans Ova." Trans Ova is a wholly owned subsidiary with primary operations in California, Iowa, Maryland, Missouri, Texas, Washington, and Wisconsin.
Effective October 1, 2019, Precigen transferred substantially all of its proprietary methane bioconversion platform ("MBP") assets to a wholly owned subsidiary, MBP Titan LLC ("MBP Titan"). MBP Titan's proprietary technology is designed to convert natural gas into more valuable and usable energy and chemical products through novel, highly engineered bacteria that utilize specific energy feedstocks. Prior to October 1, 2019, the operation transferred to MBP Titan was an operating division within Precigen. Beginning in the second quarter of 2020, the Company suspended MBP Titan's operations and began the process to wind down MBP Titan's activities and had substantially completed the wind down by December 31, 2020, with the final disposition of certain property and equipment and the facility operating lease occurring in January 2021. With the exception of certain assets and obligations with which the Company has a continuing involvement after the wind down, MBP Titan has been presented as discontinued operations for all periods presented. See Note 3 for further discussion.
On January 31, 2020, Precigen completed the sale of the majority of its non-healthcare assets and operations to an affiliate of Third Security, LLC ("Third Security"), a related party, which are presented as discontinued operations for the six months ended June 30, 2020. See Notes 3 and 13 for further discussion.
Precigen and its consolidated subsidiaries are hereinafter referred to as the "Company."
2. Summary of Significant Accounting Policies
Basis of Presentation
The accompanying interim condensed consolidated financial statements are unaudited and have been prepared in accordance with accounting principles generally accepted in the United States of America ("U.S. GAAP"). Certain information and footnote disclosures normally included in the Company's annual financial statements have been condensed or omitted. These interim condensed consolidated financial statements, in the opinion of management, reflect all normal recurring adjustments necessary for fair statement of the Company's financial position as of June 30, 2021March 31, 2022 and results of operations and cash flows for the interim periods ended June 30, 2021March 31, 2022 and 2020.2021. The year-end condensed consolidated balance sheet data was derived from the Company's audited financial statements but does not include all disclosures required by U.S. GAAP. These interim financial results are not necessarily indicative of the results to be expected for the year ending December 31, 2021,2022, or for any other future annual or interim period. The accompanying interim unaudited condensed consolidated financial statements should be read in
12

Table of Contents
conjunction with the audited consolidated financial statements and related notes thereto included in the Company's Annual Report on Form 10-K for the year ended December 31, 2020.2021.
11

Table of Contents
The accompanying condensed consolidated financial statements reflect the operations of Precigen and its subsidiaries. All intercompany accounts and transactions have been eliminated.
Liquidity
Management believes that existing liquid assets as of June 30, 2021March 31, 2022 will allow the Company to continue its operations for at least a year from the issuance date of these condensed consolidated financial statements. These condensed consolidated financial statements are presented in United States dollars. The Company is subject to a number of risks similar to those of other companies conducting high-risk, early-stage research and development of therapeutic product candidates. Principal among these risks are dependence on key individuals and intellectual property, competition from other products and companies, and the technical risks associated with the successful research, development, and clinical manufacturing of its and its collaborators' therapeutic product candidates. Additionally, the accompanying condensed consolidated financial statements have been prepared on a going concern basis, which contemplates the realization of assets and the satisfaction of liabilities in the normal course of business. During the sixthree months ended June 30, 2021,March 31, 2022, the Company incurred a net loss of $37,368$19,251 and, as of June 30, 2021,March 31, 2022, had an accumulated deficit of $1,860,758.$1,916,135. Management expects operating losses and negative cash flows to continue for the foreseeable future and, as a result, the Company will require additional capital to fund its operations and execute its business plan. In the absence of a significant source of recurring revenue, the Company's long-term success is dependent upon its ability to continue to raise additional capital in order to fund ongoing research and development reduce uses(which could occur through debt or equity issuances, sales or partnerships of cash for operating and investing activities for non-healthcare functions,non-core assets, corroborations or licensing of core or non-core assets, or other transactions), adequately satisfy or renegotiate long-term debt obligations, obtain regulatory approval of its therapeutic product candidates, successfully commercialize its therapeutic product candidates, generate revenue, meet its obligations and, ultimately, attain profitable operations.
Risks and Uncertainties
COVID-19 has had and continues to have an extensive impact on the global health and economic environments.
Commencing in the second half of March 2020, the Company's healthcare business began to experience delays to certain of its clinical trials as a result of COVID-19. For example, starting in March 2020, the Company temporarily suspended the last cohort of the Phase 1b/2a clinical trial for AG019 as a proactive measure to protect the welfare and safety of patients, caregivers, clinical site staff, its employees, and contractors. The temporary suspension of the AG019 trial was voluntary and was not related to any patient safety issues in the study. The voluntary suspension of the AG019 trial was lifted in June 2020, and recruitment in the study resumed. Additionally, from April to May 2020, enrollment of new patients in the Company's PRGN-3005 Phase 1 trial was temporarily suspended due to a mandated hold on certain early and late-stage clinical trials at the Fred Hutchinson Cancer Research Center in Seattle that was instituted in light of the COVID-19 pandemic. The temporary suspension of the PRGN-3005 trial was not related to safety issues in the studies, and in May 2020, recruitment resumed in the PRGN-3005 Phase 1 trial. Furthermore, there is uncertainty regarding the duration and severity of the ongoing pandemic, and the Company could experience further delays or other pandemic-related events that may adversely impact the Company's clinical as well as preclinical pipeline candidates in the future.
The Company is closely monitoring the impact of COVID-19 on these and otherall aspects of its business, including Trans Ova and Exemplar.businesses. Given the dynamic nature of these circumstances, the full impact of the COVID-19 pandemic on the Company's ongoing business, results of operations, and overall financial performance in future periods cannot be reasonably estimated at this time, and it could have a material adverse effect on the Company's results of operations, cash flows, and financial position, including resulting impairments to goodwill and long-lived assets and additional credit losses.
See Note 3 for further discussion of the impact of COVID-19 on MBP Titan.
Equity Method Investments
The Company accounts for its investments in each of its joint ventures ("JVs") and accounted for its investments in start-up entities backed by the Harvest Intrexon Enterprise Fund I, LP ("Harvest"), all of which are related parties, using the equity method of accounting based upon relative ownership interest. See additional discussion related to certain of the Company's JVs in Note 4 and additional discussion related to certain of the Harvest start-up entities in Note 16.
13

Table of Contents
4.
Variable Interest Entities
As of June 30, 2021March 31, 2022 and December 31, 2020,2021, the Company determined that its JVs were variable interest entities ("VIEs"). The Company was not the primary beneficiary for these entities since it did not have the power to direct the activities that most significantly impact the economic performance of the VIEs. As of June 30, 2021March 31, 2022 and December 31, 2020,2021, the Company had 0no risk of loss related to the identified VIEs. See Note 4 for discussion of the Company's future funding commitments for its significant JVs.
Net Loss per Share
Basic net loss per share is calculated by dividing net loss attributable to common shareholders by the weighted average shares outstanding during the period, without consideration of common stock equivalents. Diluted net loss per share is calculated by adjusting weighted average shares outstanding for the dilutive effect of common stock equivalents outstanding for the period, using the treasury-stock method. For purposes of the diluted net loss per share calculation, shares to be issued pursuant to convertible debt, stock options, RSUs, and warrants are considered to be common stock equivalents but are excluded from the
12

Table of Contents
calculation of diluted net loss per share because their effect would be anti-dilutive and, therefore, basic and diluted net loss per share were the same for all periods presented.
The following potentially dilutive securities as of March 31, 2022 and 2021, have been excluded from the above computations of diluted weighted average shares outstanding for the three months then ended as they would have been anti-dilutive:
March 31,
20222021
Convertible debt11,732,440 11,732,440 
Options16,034,553 11,451,614 
Restricted stock units1,185,205 790,364 
Warrants121,888 133,264 
Total29,074,086 24,107,682 
Segment Information
The Company's chief operating decision maker ("CODM") regularly reviews disaggregated financial information for various operating segments. Starting in the first quarter of 2021, the financial information regularly reviewed by the CODM was revised and the operating segments, which were determined to be operating and reportable segments, were (i) Biopharmaceuticals, (ii) Exemplar, and (iii) Trans Ova. The Biopharmaceuticals reportable segment is primarily comprised of the Company's legal entities of PGEN Therapeutics and ActoBio, as well asActoBio. All of Precigen's consolidated subsidiaries and operating divisions that did not meet the Company's majority-owned subsidiary Triple-Gene LLCquantitative thresholds to report separately are combined and its partnered program with Castle Creek Biosciences, Inc. ("Castle Creek"), represent the Biopharmaceuticals reportable segment as these businesses share resources and the CODM manages these operations asreported in a group.single category, All Other. See Note 1 for a description of PGEN Therapeutics, ActoBio, Exemplar, and Trans Ova. Corporate expenses, which are not allocated to the segments and are managed at a consolidated level, include costs associated with general and administrative functions, including the Company's finance, accounting, legal, human resources, information technology, corporate communication, and investor relations functions. Corporate expenses exclude interest expense, depreciation and amortization, gain or loss on disposals of assets, stock-based compensation expense, loss on settlement agreement, and equity in net loss of affiliates. As a result ofaffiliates and include unrealized and realized gains and losses on the revision of the reportable segments, the Company has restated its historical segment presentation to conform to the revised segment determination.Company's securities portfolio as well as dividend income. See Note 1918 for further discussion of the Company's segments.
Use of Estimates
The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenues and expenses during the reporting periods. Actual results could differ from those estimates.
Recently Adopted Accounting Pronouncements
In December 2019,August 2020, the Financial Accounting Standards Board ("FASB") issued Accounting Standards Update ("ASU") 2019-12, Income Taxes (Topic 740): Simplifying the Accounting for Income Taxes ("ASU 2019-12"). The provisions of ASU 2019-12 are intended to simplify various aspects related to accounting for income taxes by removing certain exceptions to the general principles in Accounting Standards Codification ("ASC") Topic 740 and clarifying certain aspects of the current guidance to promote consistency among reporting entities. The Company adopted this standard effective January 1, 2021, and there was no material impact to the accompanying consolidated financial statements.
Recently Issued Accounting Pronouncements
In August 2020, the FASB issued ASU 2020-06, Debt—Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging—Contracts in Entity's Own Equity (Subtopic 815-40)—Accounting for Convertible Instruments and Contracts in an Entity's Own Equity ("ASU 2020-06"). The provisions ofUnder ASU 2020-06, simplify accountingthe embedded conversion features are no longer separated from the host contract for convertible instruments by removing major separation modelswith conversion features that are not required to be accounted for as derivatives under current U.S. GAAP.Topic 815, or that do not result in substantial premiums accounted for as paid-in capital. Consequently, morea convertible debt instrumentsinstrument will be reportedaccounted for as a single liability instrument withmeasured at its amortized cost, as long as no separate accountingother features require bifurcation and recognition as derivatives. The new guidance also requires the if-converted method to be applied for embedded conversion features.all convertible instruments.
We adopted ASU 2020-06 removes certain settlement conditions that are required for equity contractson January 1, 2022 using the modified retrospective transition method, which resulted in an increase to qualify for the derivative scope exception, which will permit more equity contractsour reported long-term debt outstanding, net of current portion, of $18,196, a decrease to qualify for the exception.our additional paid-in capital of $36,868, and a corresponding cumulative-effect reduction to our opening accumulated deficit of $18,672. The adoption of ASU 2020-06 also simplifies the diluted net income per share calculation in certain areas. The amendments in ASU 2020-06 are effective for annual periods beginning after December 15, 2021, and is effective for the Companyexpected to reduce non-cash interest expense related to existing convertible debt outstanding by approximately $11,800 for the year ending December 31, 2022.2022, and did not have an impact on our consolidated cash flows. The Company is currently evaluating the impactuse of the new standardif-converted method did not have an impact on its consolidated financial statements.our overall earnings per share calculation.
1413

Table of Contents
Recently Issued Accounting Pronouncements Not Yet Adopted
There are no accounting standards which have not yet been adopted that are expected to have a significant impact on our financial statements and related disclosures.
3. Discontinued Operations
Where applicable, the notes to the accompanying condensed consolidated financial statements have been updated to reflect information pertaining to the Company's continuing operations based on the discontinued operations summarized below.
MBP Titan
As a result of market uncertainty driven by the COVID-19 pandemic and the state of the energy sector raising significant challenges for the strategic alternatives pursued by MBP Titan, beginning in the second quarter of 2020 and throughout the remainder of 2020, the Company suspended MBP Titan's operations, preserved certain of MBP Titan's intellectual property, terminated all of its personnel, and undertook steps to dispose of its other assets and obligations. The wind down of MBP Titan's activities was substantially completed by December 31, 2020, with the final disposition of certain property and equipment and the facility operating lease occurring in January 2021. This discontinuation of operations represented the continuation of a strategic shift to becoming a primarily healthcare company advancing technologies and products that address complex healthcare challenges that the Company commenced as part of the Transactions defined and discussed below.in 2020. The assets, liabilities, and expenses related to the discontinued operations of MBP Titan are reclassified and presented as discontinued operations in the accompanying condensed consolidated financial statements for all periods.
The January 2021 sale of property and equipment resulted in a gain on disposal of assets of $464, which is included in income from discontinued operations in the accompanying condensed consolidated statement of operations for the sixthree months ended June 30,March 31, 2021. In January 2021, the Company executed termination and recapture agreements with the landlord of the leased facility used in MBP Titan's operations, thereby relieving the Company of all of its obligations related to the facility that were originally due to expire in July 2025. This lease termination resulted in a gain of $4,602, which is also included in income from discontinued operations in the accompanying condensed consolidated statement of operations for the sixthree months ended June 30,March 31, 2021.
After the wind down of MBP Titan, certain assets and contractual obligations which were previously managed by MBP Titan continue to be managed at the Precigen corporate level. These remaining assets and contractual obligations include the Company's equity interest in and collaboration agreements with Intrexon Energy Partners, LLC ("Intrexon Energy Partners"), and Intrexon Energy Partners II, LLC ("Intrexon Energy Partners II"), including the associated deferred revenue remaining under each collaboration agreement (Notes 4 and 5), as well as the associated intellectual property developed by MBP Titan to date. These assets, liabilities, and related historical revenue and equity losses are included in the Company's operating results from continuing operations in the accompanying condensed consolidated financial statements for all periods presented as a result of the Company's continuing involvement.
The carrying values of the major classes of assets and liabilities included in assets and liabilities held for sale or abandonmentThere were no discontinued operations related to MBP Titan as of June 30, 2021 and Decemberfor the three months ended March 31, 2020, are as follows:
June 30,
2021
December 31,
2020
Assets
Property, plant and equipment, net$$586 
Right-of-use assets9,131 
Other assets11 136 
Total assets held for sale or abandonment$11 $9,853 
Liabilities
Lease liabilities, current$$1,890 
Other current liabilities102 619 
Lease liabilities, net of current portion11,538 
Total liabilities held for sale or abandonment$102 $14,047 
15

Table of Contents
2022. The following table presents the financial results of discontinued operations related to MBP Titan:
Three Months Ended 
 June 30,
Six Months Ended 
 June 30,
2021202020212020
Operating (gains) expenses (1)$(13)$27,645 $(4,539)$36,741 
Operating income (loss)13 (27,645)4,539 (36,741)
Income (loss) before income taxes13 (27,645)4,539 (36,741)
Income (loss) from discontinued operations$13 $(27,645)$4,539 $(36,741)
(1)Includes a goodwill impairment charge of $9,635 and an impairment charge on property, plant and equipment and right-of-use assets of $12,406 inTitan for the three and six months ended June 30, 2020 in conjunction with the suspensionMarch 31, 2021:
Three Months Ended 
 March 31,
2021
Operating gains$4,526 
Operating income4,526 
Income before income taxes4,526 
Income from discontinued operations$4,526 

14

Table of MBP Titan's operations discussed above.Contents
The following table presents the significant noncash items, purchases of property, plant and equipment, and proceeds from sales of assets for the discontinued operations related to MBP Titan for the three months ended March 31, 2021 that are included in the accompanying condensed consolidated statements of cash flows.
Six Months Ended 
 June 30,
20212020
Adjustments to reconcile net loss to net cash used in operating activities
Depreciation and amortization$$2,015 
Impairment of goodwill9,635 
Impairment of other noncurrent assets12,406 
(Gain) loss on disposals of assets, net(464)13 
Stock-based compensation expense(6)
Gain on lease termination (1)(4,602)
Cash flows from investing activities
Purchases of property, plant and equipment(88)
Proceeds from sales of assets1,083 
(1)Included in other noncash items on the accompanying condensed consolidated statement of cash flows.
Transactions with TS Biotechnology Holdings, LLC and Darling Ingredients, Inc.
On January 1, 2020, the Company and TS Biotechnology Holdings, LLC ("TS Biotechnology"), a related party and an entity managed by Third Security, entered into a Stock and Asset Purchase Agreement pursuant to which the Company agreed to sell a majority of the Company's non-healthcare assets and operations to TS Biotechnology for $53,000 and certain contingent payment rights (the "TS Biotechnology Sale"). The TS Biotechnology Sale closed on January 31, 2020. The assets and operations sold in the TS Biotechnology Sale included the following wholly owned subsidiaries, as well as certain equity securities that were directly related to the subsidiaries sold:
Intrexon Produce Holdings, Inc., the parent company of two companies focused on the development and sale of non-browning apples, Okanagan Specialty Fruits, Inc. and Fruit Orchard Holdings, Inc.;
Intrexon UK Holdings, Inc., the parent company of Oxitec Limited and its subsidiaries, which focused on biological insect solutions;
ILH Holdings, Inc., a company focused on the production of certain fine chemicals focused primarily on microbial production of therapeutic compounds; and
Blue Marble AgBio LLC which was formed in January 2020 and included certain agriculture biotechnology assets and operations that were previously an operating division within Precigen.
16

Table of Contents
Additionally, on January 2, 2020, the Company sold its equity interest in EnviroFlight, LLC ("EnviroFlight"), a JV with Darling Ingredients, Inc. ("Darling"), and related intellectual property rights to Darling for $12,200 (the "EnviroFlight Sale"). Unless referenced separately, the TS Biotechnology Sale and the EnviroFlight Sale are collectively referred to as the "Transactions".
The Transactions were approved by the Company's independent members of the board of directors in December 2019. The Transactions represented a strategic shift of the Company towards the Company becoming a primarily healthcare company advancing technologies and products that address complex healthcare challenges. The operations related to the Transactions are reclassified and presented as discontinued operations in the accompanying condensed consolidated financial statements for all periods.
Upon the closing of the TS Biotechnology Sale in January 2020, the cumulative foreign currency translation losses totaling $26,957 were released to earnings and included in loss from discontinued operations. See further discussion below.
The following table presents the financial results of discontinued operations related to the Transactions for the six months ended June 30, 2020. There were 0 discontinued operations related to the Transactions for the three months ended June 30, 2020.
 Six Months Ended June 30, 2020
 TS Biotechnology SaleEnviroFlight SaleTotal
Revenues (1)$1,294 $$1,294 
Operating expenses896 896 
Operating income398 398 
Gain on sale of discontinued operations633 39 672 
Loss on release of cumulative foreign currency translation adjustment(26,957)(26,957)
Other expense, net(129)(129)
Equity in net loss of affiliates— (38)(38)
Income (loss) before income taxes(26,055)(26,054)
Income tax expense(2)(2)
Income (loss) from discontinued operations$(26,057)$$(26,056)
(1)Includes revenue recognized from related parties of $436.
The following table presents the significant noncash items and purchases of property, plant and equipment for the discontinued operations related to the Transactions that are included in the accompanying condensed consolidated statement of cash flows.
SixThree Months Ended 
 June 30, 2020March 31,
2021
Adjustments to reconcile net loss to net cash used in operating activities
Gain on saledisposals of discontinued operationsassets, net$(672)(464)
LossNoncash gain on releasetermination of cumulative foreign currency translation adjustmentleases26,957 (4,602)
Unrealized depreciation on equity securities106 
Equity in net loss of EnviroFlight38 
Stock-based compensation expense(1,346)
Cash flows from investing activities
Purchases of property, plant and equipment(382)
Also see Note 13 below.
17

Table of Contents
Equity Method Investments
The Company accounted for its investment in EnviroFlight using the equity method of accounting.
Summarized financial data for EnviroFlight is shown in the following table for the period in which the Company held the equity method investment.
Six Months Ended 
 June 30, 2020
Revenues$16 Proceeds from sales of assets
Operating expenses92 
Operating loss(76)
Net loss$(76)1,083 
Out-of-Period Adjustment
During the six months ended June 30, 2020, the Company recorded an out-of-period adjustment of $26,572 to loss from discontinued operations which relates to the effect of cumulative foreign translation losses associated with the entities sold in the TS Biotechnology Sale. This charge, which is entirely noncash, should have been recorded in the year ended December 31, 2019 as an additional impairment charge included in loss from discontinued operations. There was no impact to net loss from continuing operations, cash and short-term investments, cash flows, or Segment Adjusted EBITDA. The error also had no impact on the cash consideration received upon closing of the TS Biotechnology Sale nor the representations and warranties made by the Company in the transaction. The Company evaluated the effects of this out-of-period adjustment, both qualitatively and quantitatively, and concluded that this adjustment was not material to the Company's results of operations for the six months ended June 30, 2020.
4. Investments in Joint Ventures
Intrexon Energy Partners
In March 2014, the Company and certain investors (the "IEP Investors"), including an affiliate of Third Security, LLC ("Third Security"), entered into a Limited Liability Company Agreement that governs the affairs and conduct of business of Intrexon Energy Partners, a JV formed to optimize and scale-up the Company's MBP technology for the production of certain fuels and lubricants. The Company also entered into an exclusive channel collaboration ("ECC") with Intrexon Energy Partners providing exclusive rights to the Company's technology for the use in bioconversion for the production of certain fuels and lubricants, as a result of which the Company received a technology access fee of $25,000 while retaining a 50% membership interest in Intrexon Energy Partners. The IEP Investors made initial capital contributions, totaling $25,000 in the aggregate, in exchange for pro rata membership interests in Intrexon Energy Partners totaling 50%. In addition, Precigen has committed to make capital contributions of up to $25,000, and the IEP Investors, as a group and pro rata in accordance with their respective membership interests in Intrexon Energy Partners, have committed to make additional capital contributions of up to $25,000, at the request of Intrexon Energy Partners' board of managers (the "Intrexon Energy Partners Board") and subject to certain limitations. As of June 30, 2021,March 31, 2022, the Company's remaining commitment was $4,225. Intrexon Energy Partners is governed by the Intrexon Energy Partners Board, which has 5 members. NaN members of the Intrexon Energy Partners Board are designated by the Company and 3 members are designated by a majority of the IEP Investors. The Company and the IEP Investors have the right, but not the obligation, to make additional capital contributions above the initial limits when and if solicited by the Intrexon Energy Partners Board.
The Company's investment in Intrexon Energy Partners was $(428)$(429) and $(425)$(428) as of June 30, 2021March 31, 2022 and December 31, 2020,2021, respectively, and is included in other accrued liabilities in the accompanying condensed consolidated balance sheets, which represents the Company's equity in losses for contractually committed contributions to Intrexon Energy Partners.
See Note 3 and 16 for additional discussion regarding the Company's investment in Intrexon Energy Partners.
Intrexon Energy Partners II
In December 2015, the Company and certain investors (the "IEPII Investors"), including Harvest, entered into a Limited Liability Company Agreement that governs the affairs and conduct of business of Intrexon Energy Partners II, a JV formed to
18

Table of Contents
utilize the Company's MBP technology for the production of 1,4-butanediol, an industrial chemical used to manufacture spandex, polyurethane, plastics, and polyester. The Company also entered into an ECC with Intrexon Energy Partners II that provides exclusive rights to the Company's technology for use in the field, as a result of which the Company received a technology access fee of $18,000 while retaining a 50% membership interest in Intrexon Energy Partners II. The IEPII Investors made initial capital contributions, totaling $18,000 in the aggregate, in exchange for pro rata membership interests in Intrexon Energy Partners II totaling 50%. In December 2015, the owners of Intrexon Energy Partners II made a capital contribution of $4,000, half of which was paid by the Company. Precigen has committed to make additional capital contributions of up to $10,000, and the IEPII Investors, as a group and pro rata in accordance with their respective membership interests in Intrexon Energy Partners II, have committed to make additional capital contributions of up to $10,000, at the request of Intrexon Energy Partners II's board of managers (the "Intrexon Energy Partners II Board") and subject to certain limitations. As of June 30, 2021,March 31, 2022, the Company's remaining commitment was $10,000. Intrexon Energy Partners II is governed by the Intrexon Energy Partners II Board, which has 5
15

Table of Contents
members. NaN member of the Intrexon Energy Partners II Board is designated by the Company and 4 members are designated by a majority of the IEPII Investors. The Company and the IEPII Investors have the right, but not the obligation, to make additional capital contributions above the initial limits when and if solicited by the Intrexon Energy Partners II Board.
The Company's investment in Intrexon Energy Partners II was $(435) as of June 30, 2021March 31, 2022 and December 31, 2020,2021, and is included in other accrued liabilities in the accompanying condensed consolidated balance sheets, which represents the Company's equity in losses for contractually committed contributions to Intrexon Energy Partners II.
See Notes 3 and 16 for additional discussion regarding the Company's investment in Intrexon Energy Partners II.
5. Collaboration and Licensing Revenue
Historically, the Company has derived collaboration and licensing revenue through agreements with counterparties for the development and commercialization of products enabled by the Company's technology platforms. These collaborations and licensing agreements may provide for multiple promises to be satisfied by the Company and typically include a license to the Company's technology platforms, participation in collaboration committees, and performance of certain research and development services. Based on the nature of the promises in the Company's collaboration and licensing agreements, the Company typically combines most of its promises into a single performance obligation because the promises are highly interrelated and not individually distinct. Options to acquire additional services are considered to determine if they constitute material rights. At contract inception, the transaction price is typically the upfront payment received and is allocated to the performance obligations. The Company has determined the transaction price should be recognized as revenue based on its measure of progress under the agreement primarily based on inputs necessary to fulfill the performance obligation.
The Company recognizes the reimbursement payments received for research and development efforts in the period when the services are performed, in connection with the single performance obligation discussed above. The reimbursements relate specifically to the Company's efforts to provide services, and the reimbursements are consistent with what the Company would typically charge other collaborators for similar services. The Company assesses the uncertainty of when and if any milestones will be achieved to determine whether the milestone is included in the transaction price. The Company then assesses whether the revenue is constrained based on whether it is probable that a significant reversal of revenue would not occur when the uncertainty is resolved. Royalties, including sales-based milestones, received under the agreements will be recognized as revenue when sales have occurred because the Company applies the sales- or usage-based royalties recognition exception provided for under ASC Topic 606. The Company determined the application of this exception is appropriate because at the time the royalties are generated, the technology license granted in the agreement is the predominant item to which the royalties relate.
The Company determines whether collaborations and licensing agreements are individually significant for disclosure based on a number of factors, including total revenue recorded by the Company pursuant to collaboration and licensing agreements, collaborators or licensees with equity method investments, or other qualitative factors. Collaboration and licensing revenues generated from consolidated subsidiaries are eliminated in consolidation.
19

Table of Contents
The following table summarizes the amounts recorded as revenue in the condensed consolidated statements of operations for each significant counterparty to a collaboration or licensing agreement for the three and six months ended June 30, 2021March 31, 2022 and 2020.2021.
Three Months Ended 
 June 30,
Six Months Ended 
 June 30,
Three Months Ended 
 March 31,
202120202021202020222021
ZIOPHARM Oncology, Inc.$$$$100 
Oragenics, Inc.32 230 
Castle Creek Biosciences, Inc.Castle Creek Biosciences, Inc.294 4,210 353 14,573 Castle Creek Biosciences, Inc.$— $59 
OtherOther73 14 133 Other— 
Total (1)Total (1)$301 $4,315 $367 $15,036 Total (1)$— $66 
(1)Collaboration and licensing revenues include the recognition of $292$0 and $4,057$66 for the three months ended June 30,March 31, 2022 and 2021, and 2020, respectively, and $358 and $14,441 for the six months ended June 30, 2021 and 2020, respectively, associated with upfront and milestone payments which were previously deferred.
There have been no significant changes to the agreements with our collaborators and licensees in the sixthree months ended June 30, 2021.March 31, 2022.
16

Table of Contents
Deferred Revenue
Deferred revenue primarily consists of upfront and milestone consideration received for the Company's collaboration and licensing agreements. Deferred revenue consisted of the following:
June 30,
2021
December 31,
2020
Collaboration and licensing agreements$23,062 $23,420 
Prepaid product and service revenues3,097 2,126 
Other140 277 
Total$26,299 $25,823 
Current portion of deferred revenue$3,276 $2,800 
Long-term portion of deferred revenue23,023 23,023 
Total$26,299 $25,823 
Revenue is recognized under collaboration and licensing agreements as services are performed. Certain of theThe arrangements classified as long-term (of which $21,205 is related to agreements with Intrexon Energy Partners L.L.C. and Intrexon Energy Partners II, L.L.C.) are not active while the other party evaluatesrespective counterparties evaluate the status of the project and its desired future development activities. The following table summarizesactivities since the remaining balanceCompany cannot reasonably estimate the amount of deferredservice to be performed over the next year.
Deferred revenue associated with upfront and milestone payments for each significant counterparty to a collaboration or licensing agreement asconsisted of June 30, 2021 and December 31, 2020, as well as the estimated remaining performance period as of June 30, 2021.following:
Average Remaining Performance Period (Years)June 30,
2021
December 31,
2020
Intrexon Energy Partners, LLC2.7$8,362 $8,362 
Intrexon Energy Partners II, LLC3.412,843 12,843 
Castle Creek Biosciences, Inc.0.535 379 
Other1.81,822 1,836 
Total$23,062 $23,420 
March 31,
2022
December 31,
2021
Collaboration and licensing agreements$23,023 $23,023 
Prepaid product and service revenues2,511 4,229 
Other158 213 
Total$25,692 $27,465 
Current portion of deferred revenue$2,669 $4,442 
Long-term portion of deferred revenue23,023 23,023 
Total$25,692 $27,465 
20

Table of Contents
0
6. Short-term and Long-term Investments
The Company's investments are classified as available-for-sale. The following table summarizes the amortized cost, gross unrealized gains and losses, and fair value of available-for-sale investments as of June 30, 2021:March 31, 2022:
Amortized
Cost
Gross
Unrealized
Gains
Gross
Unrealized
Losses
Aggregate
Fair Value
Amortized
Cost
Gross
Unrealized
Gains
Gross
Unrealized
Losses
Aggregate
Fair Value
U.S. government debt securitiesU.S. government debt securities$163,770 $$(72)$163,698 U.S. government debt securities$102,771 $— $(1,133)$101,638 
Certificates of depositCertificates of deposit265 265 Certificates of deposit97 — — 97 
TotalTotal$164,035 $$(72)$163,963 Total$102,868 $— $(1,133)$101,735 
The following table summarizes the amortized cost, gross unrealized gains and losses, and fair value of available-for-sale investments as of December 31, 2020:2021:
Amortized
Cost
Gross
Unrealized
Gains
Gross
Unrealized
Losses
Aggregate
Fair Value
Amortized
Cost
Gross
Unrealized
Gains
Gross
Unrealized
Losses
Aggregate
Fair Value
U.S. government debt securitiesU.S. government debt securities$48,048 $14 $(1)$48,061 U.S. government debt securities$121,036 $— $(331)$120,705 
Certificates of depositCertificates of deposit264 264 Certificates of deposit97 — — 97 
TotalTotal$48,312 $14 $(1)$48,325 Total$121,133 $— $(331)$120,802 
The estimated fair value of available-for-sale investments classified by their contractual maturities as of June 30, 2021March 31, 2022 was:
Due within one year$78,69471,821 
After one year through threetwo years85,26929,914 
Total$163,963101,735 
Changes in market interest rates and bond yields cause certain investments to fall below their cost basis, resulting in unrealized losses on investments. The unrealized lossesWe do not intend to sell these investments and nor is it more likely than not that the Company will be required to sell these investments, prior to maturity or recovery of the Company's debt security investments are not significant asamortized cost.
17

Table of June 30, 2021.Contents
7. Fair Value Measurements
The carrying amount of cash and cash equivalents, receivables, accounts payable, accrued compensation and benefits, other accrued liabilities, and related party payables approximate fair value due to the short maturity of these instruments.
Assets
The following table presents the placement in the fair value hierarchy of financial assets that are measured at fair value on a recurring basis as of June 30, 2021:March 31, 2022:
Quoted Prices in Active Markets
(Level 1)
Significant Other Observable Inputs
(Level 2)
Significant Unobservable Inputs
(Level 3)
June 30,
2021
Assets
U.S. government debt securities$$163,698 $$163,698 
Other265 265 
Total$$163,963 $$163,963 
21

Table of Contents
Quoted Prices in Active Markets
(Level 1)
Significant Other Observable Inputs
(Level 2)
Significant Unobservable Inputs
(Level 3)
March 31,
2022
Assets
U.S. government debt securities$— $101,638 $— $101,638 
Certificates of deposit— 97 — 97 
Total$— $101,735 $— $101,735 
The following table presents the placement in the fair value hierarchy of financial assets that are measured at fair value on a recurring basis as of December 31, 2020:2021:
Quoted Prices in Active Markets
(Level 1)
Significant Other Observable Inputs
(Level 2)
Significant Unobservable Inputs
(Level 3)
December 31,
2020
Quoted Prices in Active Markets
(Level 1)
Significant Other Observable Inputs
(Level 2)
Significant Unobservable Inputs
(Level 3)
December 31,
2021
AssetsAssetsAssets
U.S. government debt securitiesU.S. government debt securities$$48,061 $$48,061 U.S. government debt securities$— $120,705 $— $120,705 
Other264 264 
Certificates of depositCertificates of deposit— 97 — 97 
TotalTotal$$48,325 $$48,325 Total$— $120,802 $— $120,802 
The method used to estimate the fair value of the Level 2 short-term and long-term debt investments in the tables above is based on professional pricing sources for identical or comparable instruments, rather than direct observations of quoted prices in active markets.
Liabilities
The carrying values of the Company's long-term debt, excluding the 3.50% convertible senior notes due 2023 (the "Convertible Notes"), approximates fair value due to the length of time to maturity and/or the existence of interest rates that approximate prevailing market rates.
The calculated fair value of the Convertible Notes (Note 11) was approximately $173,000$164,000 and $165,000$160,000 as of June 30, 2021March 31, 2022 and December 31, 2020,2021, respectively, and is based on the recent third-party trades of the instrument as of the balance sheet date. The fair value of the Convertible Notes is classified as Level 2 within the fair value hierarchy as there is not an active market for the Convertible Notes, however, third-party trades of the instrument are considered observable inputs. The Convertible Notes are reflected on the accompanying condensed consolidated balance sheets at amortized cost, which was $173,777$198,362 and $168,147$179,882 as of June 30, 2021March 31, 2022 and December 31, 2020, respectively.2021, respectively (see Note 2 regarding adoption of ASU 2020-06 on January 1, 2022).
18


8. Inventory
Inventory consists of the following:
June 30,
2021
December 31,
2020
March 31,
2022
December 31,
2021
Supplies, embryos and other production materialsSupplies, embryos and other production materials$2,098 $2,060 Supplies, embryos and other production materials$2,931 $2,588 
Work in processWork in process2,624 2,348 Work in process2,539 2,564 
LivestockLivestock5,640 5,047 Livestock5,918 6,310 
FeedFeed1,051 1,904 Feed1,342 1,799 
Total inventoryTotal inventory$11,413 $11,359 Total inventory$12,730 $13,261 
22

Table of Contents
9. Property, Plant and Equipment, Net
Property, plant and equipment consist of the following:
June 30,
2021
December 31,
2020
March 31,
2022
December 31,
2021
Land and land improvementsLand and land improvements$9,844 $9,844 Land and land improvements$11,118 $11,118 
Buildings and building improvementsBuildings and building improvements12,088 12,088 Buildings and building improvements12,903 12,896 
Furniture and fixturesFurniture and fixtures1,232 1,228 Furniture and fixtures1,193 1,162 
EquipmentEquipment32,069 31,150 Equipment34,304 33,584 
Leasehold improvementsLeasehold improvements6,445 6,260 Leasehold improvements4,822 4,822 
Breeding stockBreeding stock1,001 868 Breeding stock953 1,000 
Computer hardware and softwareComputer hardware and software5,747 5,684 Computer hardware and software5,169 5,131 
Construction and other assets in progressConstruction and other assets in progress2,186 2,754 Construction and other assets in progress3,596 3,824 
70,612 69,876 74,058 73,537 
Less: Accumulated depreciation and amortizationLess: Accumulated depreciation and amortization(37,867)(34,952)Less: Accumulated depreciation and amortization(40,475)(39,222)
Property, plant and equipment, netProperty, plant and equipment, net$32,745 $34,924 Property, plant and equipment, net$33,583 $34,315 
Depreciation expense was $1,593$1,483 and $1,896$1,593 for the three months ended June 30,March 31, 2022 and 2021, and 2020, respectively, and $3,186 and $3,816 for the six months ended June 30, 2021 and 2020, respectively.
10. Goodwill and Intangible Assets, Net
The changes in the carrying amount of goodwill for the sixthree months ended June 30, 2021March 31, 2022 were as follows:
Balance at December 31, 20202021$54,36354,148 
Impairment(482)
Foreign currency translation adjustments(90)(53)
Balance at June 30, 2021March 31, 2022$54,27353,613 
The Company recorded $482 of goodwill impairment related to the total goodwill assigned to 1 reporting unit within the biopharmaceutical segment during the first quarter of 2022.
The Company had $44,125 and $43,643 of cumulative impairment losses as of June 30, 2021March 31, 2022 and December 31, 2020.2021, respectively.
19

Table of Contents
Intangible assets consist of the following as of June 30, 2021:March 31, 2022:
Gross Carrying AmountAccumulated AmortizationNetGross Carrying AmountAccumulated AmortizationNet
Patents, developed technologies and know-howPatents, developed technologies and know-how$94,600 $(36,746)$57,854 Patents, developed technologies and know-how$90,000 $(39,595)$50,405 
Customer relationshipsCustomer relationships10,850 (9,796)1,054 Customer relationships10,850 (10,480)370 
TrademarksTrademarks5,900 (4,866)1,034 Trademarks5,900 (5,248)652 
TotalTotal$111,350 $(51,408)$59,942 Total$106,750 $(55,323)$51,427 
Intangible assets consist of the following as of December 31, 2020:2021:
Gross Carrying AmountAccumulated AmortizationNet
Patents, developed technologies and know-how$96,927 $(34,412)$62,515 
Customer relationships10,850 (9,340)1,510 
Trademarks5,900 (4,529)1,371 
Total$113,677 $(48,281)$65,396 
23

Table of Contents
Gross Carrying AmountAccumulated AmortizationNet
Patents, developed technologies and know-how$91,373 $(38,630)$52,743 
Customer relationships10,850 (10,252)598 
Trademarks5,900 (5,126)774 
Total$108,123 $(54,008)$54,115 
Amortization expense was $1,928$1,809 and $1,883$1,930 for the three months ended June 30,March 31, 2022 and 2021, and 2020, respectively, and $3,857 and $3,762 for the six months ended June 30, 2021 and 2020, respectively.
11. Lines of Credit and Long-Term Debt
Lines of Credit
Trans Ova hashad a $5,000 revolving line of credit with First National Bank of Omaha that maturesmatured on April 1, 2022. The line of credit bearsbore interest at the greater of the U.S. Prime Rate or 3.00%, and the actual rate was 3.25%3.50% as of June 30, 2021.March 31, 2022. As of June 30,March 31, 2022 and December 31, 2021, there was 0no outstanding balance. The amount available under the line of credit iswas based on eligible accounts receivable and inventory up to the maximum principal amount and was $5,000 as of June 30, 2021. The line of credit is collateralized by certain of Trans Ova's assets and contains certain restricted covenants that include maintaining minimum tangible net worth and working capital and maximum allowable annual capital expenditures.March 31, 2022.
Exemplar has a $700 revolving line of credit with American State Bank that matures on October 31, 2021.2022. As of June 30, 2021,March 31, 2022, the line of credit bore interest at a stated rate of 4.00% per annum,annum. As of March 31, 2022 and December 31, 2021, there was 0no outstanding balance.
Long-Term Debt
Long-term debt consists of the following:
June 30,
2021
December 31,
2020
March 31,
2022
December 31,
2021
Convertible debt(1)Convertible debt(1)$173,777 $168,147 Convertible debt(1)$198,362 $179,882 
Notes payableNotes payable3,438 3,655 Notes payable3,105 3,217 
OtherOther63 80 Other— 52 
Long-term debtLong-term debt177,278 171,882 Long-term debt201,467 183,151 
Less current portionLess current portion356 360 Less current portion355 402 
Long-term debt, less current portionLong-term debt, less current portion$176,922 $171,522 Long-term debt, less current portion$201,112 $182,749 
20


(1)See Note 2 regarding adoption of ASU 2020-06 as of January 1, 2022.
Convertible Debt
Precigen Convertible Notes
In July 2018, Precigen completed a registered underwritten public offering of $200,000 aggregate principal amount of Convertible Notes and issued the Convertible Notes under an indenture (the "Base Indenture") between Precigen and The Bank of New York Mellon Trust Company, N.A., as trustee, as supplemented by the First Supplemental Indenture (together with the Base Indenture, the "Indenture"). Precigen received net proceeds of $193,958 after deducting underwriting discounts and offering expenses of $6,042.
The Convertible Notes are senior unsecured obligations of Precigen and bear interest at a rate of 3.50% per year, payable semiannually in arrears on January 1 and July 1 of each year beginning on January 1, 2019. The Convertible Notes mature on July 1, 2023 and are repayable in cash, unless earlier repurchased or converted. Upon conversion by the holders, the Convertible Notes are convertible into cash, shares of Precigen's common stock or a combination of cash and shares, at Precigen's election. The initial conversion rate of the Convertible Notes is 58.6622 shares of Precigen common stock per $1,000 principal amount of Convertible Notes (equivalent to an initial conversion price of approximately $17.05 per share of common stock). The conversion rate is subject to adjustment upon the occurrence of certain events, but will not be adjusted for any accrued and unpaid interest. In addition, following certain corporate events that occur prior to the maturity date as defined in the Indenture, Precigen will increase the conversion rate for a holder who elects to convert its Convertible Notes in connection with such a corporate event in certain circumstances. Prior to April 1, 2023, the holders may convert the Convertible Notes at their option only upon the satisfaction of the following circumstances:
During any calendar quarter commencing after the calendar quarter ended on September 30, 2018, if the last reported sales price of Precigen's common stock for at least 20 trading days (whether or not consecutive) during the last 30 consecutive trading days of the immediately preceding calendar quarter is greater than or equal to 130% of the conversion price on each applicable trading day;
24


During the 5 business day period after any 5 consecutive trading day period in which the trading price, as defined in the Indenture, for the Convertible Notes is less than 98% of the product of the last reported sales price of Precigen's common stock and the conversion rate for the Convertible Notes on each such trading day; or
Upon the occurrence of specified corporate events as defined in the Indenture.
None of the above events allowing for conversion prior to April 1, 2023 occurred during the three months ended June 30, 2021.March 31, 2022. On or after April 1, 2023 until June 30, 2023, holders may convert their Convertible Notes at any time. Precigen may not redeem the Convertible Notes prior to the maturity date.
If Precigen undergoes a fundamental change, as defined in the Indenture, holders of the Convertible Notes may require Precigen to repurchase for cash all or any portion of their Convertible Notes at a fundamental change repurchase price equal to 100% of the principal amount of the Convertible Notes to be repurchased, plus accrued and unpaid interest to, but excluding, the fundamental change repurchase date. The Indenture contains customary events of default, as defined in the agreement, and, if any of the events occur, could require repayment of a portion or all of the Convertible Notes, including accrued and unpaid interest. Additionally, the Indenture provides that Precigen shall not consolidate with or merge with or into, or sell, convey, transfer or lease all or substantially all of its properties and assets to, another entity, unless (i) the surviving entity is organized under the laws of the United States and such entity expressly assumes all of Precigen's obligations under the Convertible Notes and the Indenture; and (ii) immediately after such transaction, no default or event of default has occurred and is continuing under the Indenture.
The net proceeds received from the issuance of the Convertible Notes were initially allocated between long-term debt, the liability component, in the amount of $143,723, and additional paid-in capital, the equity component, in the amount of $50,235. Additional paid-in capital was further reduced by $13,367 of deferred taxes resulting from the difference between the carrying amount and the tax basis of the Convertible Notes that is created by the equity component, which also resulted in deferred tax benefit recognized from the reversal of valuation allowances on the then current year domestic operating losses in the same amount.

As described in Note 2, the Company adopted ASU 2020-06 on January 1, 2022. Pursuant to ASU 2020-06, the equity components of the Convertible Notes separated from the debt components as required under the cash conversion model is required to be recombined into the Convertible Notes as a single instrument upon the adoption of ASU 2020-06. The
21


Convertible Notes shall be accounted for as if the conversion option had not been separated. As the Company elected the modified retrospective approach, the difference between the accounting under the cash conversion model and new model after the adoption of ASU 2020-06 (i.e., the single debt instrument with no separation) was recorded as an adjustment on the adoption date (i.e., January 1, 2022) through accumulated deficit. Tax accounting consequences of the adoption also required the reversal of the previously reported deferred tax benefit on the date of adoption.

Adoption of ASU 2020-06 resulted in an increase to long-term debt outstanding, net of current portion, of $18,196, a decrease to additional paid-in capital of $36,868, and a decrease to accumulated deficit of $18,672. Interest expense recognized on the convertible notes in future periods will be reduced as a result of accounting for the convertible debt instrument as a single liability measured at its amortized cost.

As of June 30, 2021,March 31, 2022, the outstanding principal balance on the Convertible Notes was $200,000 and the carrying value of long-term debt was $173,777.$198,362. The effective interest rate on the Convertible Notes, including amortization of the long-term debt discount and debt issuance costs, is 11.02%4.25%. As of June 30, 2021,March 31, 2022, the unamortized long-term debt discount and debt issuance costs totaled $26,223.$1,638.
The components of interest expense related to the Convertible Notes were as follows:
Three Months Ended 
 June 30,
Six Months Ended 
 June 30,
Three Months Ended 
 March 31,
2021202020212020 20222021
Cash interest expenseCash interest expense$1,750 $1,750 $3,500 $3,500 Cash interest expense$1,750 $1,750 
Non-cash interest expenseNon-cash interest expense2,879 2,585 5,630 5,101 Non-cash interest expense284 2,751 
Total interest expenseTotal interest expense$4,629 $4,335 $9,130 $8,601 Total interest expense$2,034 $4,501 
Accrued interest of $3,500$1,750 is included in other accrued liabilities on the accompanying condensed consolidated balance sheet as of June 30, 2021.
ActoBio Convertible Notes
In September 2018, ActoBio issued $30,000 of convertible promissory notes (the "ActoBio Notes") to a related party in conjunction with an asset acquisition with Harvest. The ActoBio Notes, which accrued interest at 3.0% compounded annually ("accrued PIK interest"), matured in September 2020. The Company issued 6,293,402 shares of Precigen common stock upon conversion of the outstanding principal balance and accrued PIK interest at maturity. Interest expense was $234 and $469 for the three and six months ended June 30, 2020, respectively.
Precigen and PGEN Therapeutics Convertible Note
In December 2018, in conjunction with the Securities Purchase, Assignment and Assumption Agreement with Ares Trading S.A. ("Ares Trading"), Precigen and PGEN Therapeutics jointly and severally issued a $25,000 convertible note (the "Merck Note") to Ares Trading in exchange for cash. In October 2020, pursuant to the terms of the Merck Note, Ares Trading voluntarily elected to convert the entire $25,000 outstanding into 6,758,400 shares of Precigen common stock.
25


March 31, 2022.
Notes Payable
Trans Ova has a note payable to American State Bank that matures in April 2033 and had an outstanding principal balance of $3,438$3,105 as of June 30, 2021.March 31, 2022. Trans Ova pays monthly installments of $39, which includes interest at 3.95%. The note payable is collateralized by certain of Trans Ova's real estate and non-real estate assets.
Future Maturities
Future maturities of long-term debt as of June 30, 2021March 31, 2022 are as follows:
2021$181 
20222022399 2022$265 
20232023200,362 2023200,365 
20242024376 2024380 
20252025392 2025395 
20262026407 2026411 
20272027428 
ThereafterThereafter1,384 Thereafter861 
TotalTotal$203,501 Total$203,105 
12. Income Taxes
Tax provisions for interim periods are calculated using an estimate of actual taxable income or loss for the respective period, rather than estimating the Company's annual effective income tax rate, as the Company is currently unable to reliably estimate its income for the full year. The Company has U.S. taxable loss of approximately $17,100$5,300 and $27,700$40,400 for the three months ended June 30,March 31, 2022 and 2021, and 2020, respectively, and $57,500 and $107,000 for the six months ended June 30, 2021 and 2020, respectively. The following table presents the components of income tax benefit from continuing operations.
 Three Months Ended 
 June 30,
Six Months Ended 
 June 30,
 2021202020212020
Current foreign income tax expense from continuing operations$$16 $$56 
Deferred income tax benefit from continuing operations(63)(136)(119)(136)
Total income tax benefit from continuing operations$(60)$(120)$(112)$(80)
22


 Three Months Ended 
 March 31,
 20222021
Current foreign income tax expense from continuing operations$— $
Deferred income tax benefit from continuing operations(58)(56)
Total income tax benefit from continuing operations$(58)$(52)
The Company's net deferred tax assets, excluding certain deferred tax liabilities totaling $2,692,$2,438, are offset by a valuation allowance due to the Company's history of net losses combined with an inability to confirm recovery of the tax benefits of the Company's losses and other net deferred tax assets. In assessing the realizability of deferred tax assets, management considers whether it is more likely than not that some portion or all of the deferred tax assets will not be realized. The ultimate realization of deferred tax assets is dependent upon the generation of future taxable income during the periods in which those temporary differences become deductible. Management considers the scheduled reversal of deferred tax liabilities, projected future taxable income and tax planning strategies in making this assessment.
As of June 30, 2021,March 31, 2022, the Company hashad net operating loss carryforwards for U.S. federal income tax purposes of approximately $813,700$861,000 available to offset future taxable income, including approximately $561,000$609,000 generated after 2017, U.S. capital loss carryforwards of approximately $211,500,$212,500, and federal and state research and development tax credits of approximately $10,500,$11,300, prior to consideration of annual limitations that may be imposed under Section 382 of the Internal Revenue Code of 1986, as amended. Net operating loss carryforwards generated prior to 2018 will beginhave begun to expire in 2022, and capital loss carryforwards will expire if unutilized beginning in 2024. As of June 30, 2021,March 31, 2022, the Company's foreign subsidiaries have foreign loss carryforwards of approximately $79,100,$74,200, most of which do not expire.
26


13. Shareholders' Equity
Issuances of Precigen Common Stock
In January 2021, the Company closed a public offering of 17,250,000 shares of its common stock, resulting in net proceeds of $121,045, after deducting underwriting discounts and $568 of capitalized offering expenses.
Concurrent with entering into the TS Biotechnology Sale on January 1, 2020, the Company also entered into a subscription agreement with TS Biotechnology pursuant to which TS Biotechnology purchased 5,972,696 shares of the Company's common stock for $35,000 on January 31, 2020.
See NotesNote 11 and 17 for discussion regarding additional issuancesconversion features of Precigen common stock.the convertible notes.
Share Lending Agreement
Concurrently with the offering of the Convertible Notes (Note 11), Precigen entered into a share lending agreement (the "Share Lending Agreement") with J.P. Morgan Securities LLC (the "Share Borrower") pursuant to which Precigen loaned and delivered 7,479,431 shares of its common stock (the "Borrowed Shares") to the Share Borrower. The Share Lending Agreement will terminate, and the Borrowed Shares will be returned to Precigen within five business days of such termination, upon (i) termination by the Share Borrower or (ii) the earliest to occur of (a) October 1, 2023 and (b) the date, if any, on which the Share Lending Agreement is either mutually terminated or terminated by one party upon a default by the other party. The Share Borrower maintains collateral in the form of cash or certain permitted non-cash collateral with a market value at least equal to the market value of the Borrowed Shares as security for the obligation of the Share Borrower to return the Borrowed Shares when required by the terms above. The Borrowed Shares were offered and sold to the public at a price of $13.37 per share under a registered offering (the "Borrowed Shares Offering"). Precigen did not receive any proceeds from the sale of the Borrowed Shares to the public or any lending fees from the Share Lending Agreement. The Share Borrower or its affiliates received all the proceeds from the sale of the Borrowed Shares to the public. Affiliates of Third Security purchased all of the shares of common stock in the Borrowed Shares Offering.
The Share Lending Agreement was entered into at fair value and met the requirements for equity classification. Therefore, the value is netted against the issuance of the Borrowed Shares in additional paid-in capital. Additionally, the Borrowed Shares are not included in the denominator for loss per share attributable to Precigen shareholders unless the Share Borrower defaults on the Share Lending Agreement.
23


Components of Accumulated Other Comprehensive (Loss) Income
The components of accumulated other comprehensive (loss) income are as follows:
June 30,
2021
December 31,
2020
Unrealized gain (loss) on investments$(72)$13 
Income on foreign currency translation adjustments2,613 3,984 
Total accumulated other comprehensive income$2,541 $3,997 
March 31,
2022
December 31,
2021
Unrealized loss on investments$(1,133)$(331)
Income (loss) on foreign currency translation adjustments(566)534 
Total accumulated other comprehensive (loss) income$(1,699)$203 
27


14. Share-Based Payments
The Company measures the fair value of stock options and restricted stock units ("RSUs") issued to employees and nonemployees as of the grant date for recognition of stock-based compensation expense. Stock-based compensation expense for employees and nonemployees is recognized over the requisite service period, which is typically the vesting period. Stock-based compensation costs included in the condensed consolidated statements of operations are presented below:
Three Months Ended 
 June 30,
Six Months Ended 
 June 30,
Three Months Ended 
 March 31,
202120202021202020222021
Cost of productsCost of products$$$15 $Cost of products$$
Cost of servicesCost of services34 35 99 64 Cost of services31 65 
Research and developmentResearch and development587 413 1,625 948 Research and development548 1,038 
Selling, general and administrativeSelling, general and administrative2,930 4,531 7,233 9,603 Selling, general and administrative2,975 4,303 
Discontinued operations(84)(1,352)
TotalTotal$3,557 $4,897 $8,972 $9,269 Total$3,562 $5,415 
Precigen Stock Option Plans
In April 2008, Precigen adopted the 2008 Equity Incentive Plan (the "2008 Plan") for employees and nonemployees pursuant to which Precigen's board of directors granted share-based awards, including stock options, to officers, key employees and nonemployees. Upon the effectiveness of the 2013 Omnibus Incentive Plan (the "2013 Plan"), 0no new awards may be granted under the 2008 Plan. As of June 30, 2021,March 31, 2022, there were 157,69514,843 stock options outstanding under the 2008 Plan.
Precigen adopted the 2013 Plan for employees and nonemployees pursuant to which Precigen's board of directors may grant share-based awards, including stock options and shares of common stock, to employees, officers, consultants, advisors, and nonemployee directors. The 2013 Plan became effective in August 2013, and as of June 30, 2021,March 31, 2022, there were 27,000,000 shares authorized for issuance under the 2013 Plan, of which 11,436,37414,121,502 stock options and 338,454569,445 RSUs were outstanding and 5,614,3262,085,537 shares were available for grant. In April 2022, Precigen's board of directors approved, subject to shareholder approval at Precigen's annual meeting in June 2022, an increase of 10,000,000 shares of common stock to be reserved for issuance under the 2013 Plan.
In April 2019, Precigen adopted the 2019 Incentive Plan for Non-Employee Service Providers (the "2019 Plan"), which became effective upon shareholder approval in June 2019. The 2019 Plan permits the grant of share-based awards, including stock options, restricted stock awards, and RSUs, to non-employee service providers, including board members. As of June 30, 2021,March 31, 2022, there were 5,000,000 shares authorized for issuance under the 2019 Plan, of which 1,066,3181,898,208 stock options and 215,692615,760 RSUs were outstanding and 1,974,662243,025 shares were available for grant. In April 2022, Precigen's board of directors approved, subject to shareholder approval at Precigen's annual meeting in June 2022, an increase of 7,000,000 shares of common stock to be reserved for issuance under the 2019 Plan.
2824


Stock option activity was as follows:
Number of SharesWeighted Average Exercise PriceWeighted Average Remaining Contractual Term (Years)Number of SharesWeighted Average Exercise PriceWeighted Average Remaining Contractual Term (Years)
Balances at December 31, 202011,255,896 $15.53 7.25
Balances at December 31, 2021Balances at December 31, 202112,260,187 $14.06 6.79
GrantedGranted1,766,320 8.06 Granted4,009,390 2.27 
ExercisedExercised(47,508)(5.30)Exercised(375)2.28 
ForfeitedForfeited(164,202)(6.16)Forfeited(210,613)5.63 
ExpiredExpired(150,119)(29.97)Expired(24,036)11.85 
Balances at June 30, 202112,660,387 14.47 7.03
Exercisable at June 30, 20217,457,512 17.06 5.75
Balances at March 31, 2022Balances at March 31, 202216,034,553 11.22 7.31
Exercisable at March 31, 2022Exercisable at March 31, 20228,937,195 14.85 5.99
RSU activity was as follows:
Number of Restricted Stock UnitsWeighted Average Grant Date Fair ValueWeighted Average Remaining Contractual Term (Years)Number of Restricted Stock UnitsWeighted Average Grant Date Fair ValueWeighted Average Remaining Contractual Term (Years)
Balances at December 31, 20201,727,712 $6.11 0.42
Balances at December 31, 2021Balances at December 31, 2021468,481 $8.47 0.33
GrantedGranted462,019 7.87 Granted1,387,831 2.12 
VestedVested(1,545,442)(5.68)Vested(669,041)5.71 
ForfeitedForfeited(90,143)(8.80)Forfeited(2,066)7.26 
Balances at June 30, 2021554,146 8.36 0.74
Balances at March 31, 2022Balances at March 31, 20221,185,205 2.60 0.59
Precigen currently uses authorized and unissued shares to satisfy share award exercises.
The Company's Executive Chairman ("Executive Chairman"), who previously served as an employee and executive officer until September 24, 2020, received a base salary of $200 per month through March 31, 2020, payable in fully-vested shares of Precigen common stock with such shares subject to a three-year lock-up on resale. In September 2020, the Company's board of directors, upon the recommendation of the compensation committee of the board, approved a new compensation arrangement for the Executive Chairman consisting of (i) an annual retainer of $100 payable in cash or, at the Executive Chairman's election, shares of Precigen common stock; (ii) an annual grant of fully vested stock options having a grant date fair value of $250; and (iii) an annual grant of RSUs having a grant date fair value of $250 vesting over one year. The new compensation arrangement began in calendar year 2021 and was prorated for the nine months of 2020 not covered by the Executive Chairman's previous compensation arrangement discussed above. Expense associated with the arrangements above is included in selling, general, and administrative expenses in the Company's condensed consolidated statements of operations and totaled $109$433 and $0$400 for the three months ended June 30, 2021March 31, 2022 and 2020, respectively, and $509 and $454 for the six months ended June 30, 2021 and 2020, respectively.2021.
15. Operating Leases
The Company leases certain facilities and equipment under operating leases. Leases with a lease term of twelve months or less are considered short-term leases and are not recorded on the balance sheet, and expense for these leases is recognized over the term of the lease. All other leases have remaining terms of one to nine years, some of which may include options to extend the lease and some of which may include options to terminate the lease within one year. The Company uses judgment to determine whether it is reasonably possible to extend the lease beyond the initial term or terminate before the initial term ends and the length of the possible extension or early termination. The leases are renewable at the option of the Company and do not contain residual value guarantees, covenants, or other restrictions.
2925


The components of lease costs were as follows:
Three Months Ended 
 June 30,
Six Months Ended 
 June 30,
Three Months Ended 
 March 31,
202120202021202020222021
Operating lease costsOperating lease costs$829 $897 $1,668 $1,798 Operating lease costs$729 $839 
Short-term lease costsShort-term lease costs441 415 947 852 Short-term lease costs463 506 
Variable lease costsVariable lease costs234 225 464 449 Variable lease costs117 230 
Lease costsLease costs$1,504 $1,537 $3,079 $3,099 Lease costs$1,309 $1,575 
As of June 30, 2021,March 31, 2022, maturities of lease liabilities, excluding short-term and variable leases, for continuing operations were as follows:
2021$1,600 
202220223,433 2022$2,117 
202320232,972 20232,519 
202420243,033 20242,528 
202520252,306 20252,259 
202620261,808 20261,778 
202720271,345 
ThereafterThereafter4,638 Thereafter3,292 
TotalTotal19,790 Total15,838 
Present value adjustmentPresent value adjustment(6,032)Present value adjustment(4,740)
TotalTotal$13,758 Total$11,098 
Current portion of operating lease liabilitiesCurrent portion of operating lease liabilities$1,937 Current portion of operating lease liabilities$1,590 
Long-term portion of operating lease liabilitiesLong-term portion of operating lease liabilities11,821 Long-term portion of operating lease liabilities9,508 
TotalTotal$13,758 Total$11,098 
Other information related to operating leases in continuing operations was as follows:
June 30,
2021
December 31,
2020
March 31,
2022
December 31,
2021
Weighted average remaining lease term (years)Weighted average remaining lease term (years)6.504.21Weighted average remaining lease term (years)6.306.65
Weighted average discount rateWeighted average discount rate10.96 %10.27 %Weighted average discount rate10.99 %10.99 %
Six Months Ended 
 June 30,
Three Months Ended 
 March 31,
2021202020222021
Supplemental disclosure of cash flow informationSupplemental disclosure of cash flow informationSupplemental disclosure of cash flow information
Cash paid for operating lease liabilitiesCash paid for operating lease liabilities$1,955 $2,000 Cash paid for operating lease liabilities$744 $1,005 
Operating lease right-of-use assets obtained in exchange for new lease liabilities (includes new leases or modifications of existing leases)Operating lease right-of-use assets obtained in exchange for new lease liabilities (includes new leases or modifications of existing leases)4,868 90 Operating lease right-of-use assets obtained in exchange for new lease liabilities (includes new leases or modifications of existing leases)556 55 
16. Commitments and Contingencies
Contingencies
On December 1, 2020, Trans Ova settled 1 of 2 patent infringement lawsuits brought by XY, LLC ("XY"). The lawsuit, originally filed in 2012, was tried and appealed between 2016 and 2020. On December 1, 2020, the parties reached a settlement resolving all remaining disputes. As part of that settlement, Trans Ova remitted to XY a settlement payment, which, in addition to all the other monies Trans Ova had previously paid XY, constituted full payment and satisfaction of the judgment, including pre-judgment interest, post-judgment interest, costs, and all past, current and future royalty obligations under the judgment. In exchange, XY released and forever discharged Trans Ova from all obligations arising out of the judgment.
3026

Table of Contents
AXY filed a second patent infringement lawsuit brought on by XY was filed in December 2016.2016, alleging infringement of 7 additional patents. Two of those patents were later invalidated in different proceedings and dismissed from the lawsuit. A third patent was settled out of the case in April 2022. There are thus currently 54 patents remaining at issue in the case. Of these, one patent expired on May 9, 2021, and another expires on May 21, 2022. As for the last two patents, Trans Ova has stopped practicing the technologies claimed therein. The Company expects thea trial to occur sometime in January 2022.
2023. While this patent infringement lawsuitTrans Ova is pending,confident in its claims and defenses, litigation is uncertain and there is a possibility that the Trans Ova is found liable and ordered to pay damages for past infringement. In the interim, Trans Ova shall continue to utilizeoperate its business otherwise unaffected by the technology consistent with the determinations of the court proceedings. Nonetheless, these disputes remain subject to a number of uncertainties, including the outcome of district court and appellate proceedings, the possibility of further claims by XY, and the impact of these matters on Trans Ova's ability to utilize the technology. Trans Ova and the Company could elect to enter into a settlement agreement in order to avoid the further costs and uncertainties of litigation.
In September 2020, the Company reached a final settlement with the Securities and Exchange Commission ("SEC") with respect to an investigation concerning the Company's disclosures regarding its MBP program in the first three quarters of 2017. Under the terms of the settlement, the Company, without admitting or denying the allegations of the SEC, consented to the entry of an administrative order requiring that the Company: (i) cease and desist from committing or causing any violations and future violations under Section 13(a) of the Securities Exchange Act of 1934, as amended, and Rules 13a-11 and 12b-20 promulgated thereunder; and (ii) pay a $2,500 civil money penalty to the SEC.SEC (which was paid in September 2020).
In October 2020, several purported shareholder class action lawsuits were filed in the U.S.United States District Court for the Northern District of California on behalf of certain purchasers of the Company's common stock. The complaints name as defendants the Company and certain of its current and former officers. The plaintiff'splaintiffs' claims track the allegations in the SEC's administrative order described above but challenge disclosures about the MBP program through September 2020, i.e., the date of the SEC administrative order. The plaintiffs seek compensatory damages, interest, and an award of reasonable attorney'sattorneys' fees and costs. In April 2021, the court granted an order consolidating the claims and appointed a lead plaintiff and lead counsel in the case, captioned Abailla v. Precigen, Inc., F/K/A Intrexon Corp., et al. In May 2021, the lead plaintiff filed an amended complaint. The defendants moved to dismiss that complaint. In September 2021, the court issued an order mooting the defendants' motion to dismiss in light of the lead plaintiff's stated intent to file a second amended complaint in response to the motion to dismiss. On September 27, 2021, the lead plaintiff filed a second amended complaint. On April 7, 2022, at a hearing on the Company’s motion, the Court indicated that the second amended complaint would be dismissed with leave to amend. Plaintiffs’ counsel indicated a new complaint would be filed. The defendants intend to move to dismiss that complaint.
In December 2020, a derivative shareholder action, captioned Edward D. Wright, derivatively on behalf of Precigen, Inc. F/K/A Intrexon Corp. v. Alvarez et al, was filed in the Circuit Court for Fairfax County in Virginia on behalf of Precigen, Inc. asserting similar claims under state law against Precigen's current directors and certain officers. The plaintiff seeks damages, forfeiture of benefits received by defendants, and an award of reasonable attorneys' fees and costs. The case was stayed by an order entered on June 14, 2021. On September 24, 2021, an individual shareholder filed a lawsuit in the Circuit Court for Henrico County styled Kent v. Precigen, Inc., Case CL21-6349. The Kent action demands inspection of certain books and records of the Company pursuant to Virginia statutory and common law. On April 1, 2022, the court denied the demurrer and referred the matter to a hearing on the merits. The Company is evaluating how best to proceed.
The Company intends to defend the lawsuits vigorously; however, there can be no assurances regarding the ultimate outcome of these lawsuits.
On July 10, 2020, the Company received a notice of arbitration from Harvest pursuant to the Collaboration Investment Opportunity Agreement dated March 13, 2015. In December 2020, the Company entered into an agreement with Harvest to resolve matters related to the parties' contractual and equity relationships and to settle all claims made in connection with the notice of arbitration noted above. Pursuant to the settlement agreement, the Company issued 2,117,264 shares of its common stock to Harvest valued at $18,103 in consideration of (i) the termination of the ECC agreements with Thrive Agrobiotics, Inc., Exotech Bio, Inc., and AD Skincare, Inc., which the Company had $6,993 of deferred revenue remaining related to these ECCs prior to the settlement agreement; (ii) the return of the Company's ownership interest in these Harvest start-up entities that had a total value of $326 prior to the settlement agreement; (iii) the commitment of Harvest to take reasonable commercial efforts to transfer to the Company its membership interests in Intrexon Energy Partners II; and (iv) mutual irrevocable and unconditional releases of claims. The Company wrote off the investment balances and netted the deferred revenue balances associated with the eliminated service obligation against the consideration paid. Outstanding receivables from these Harvest start-up entities related to research and development services performed by the Company under the ECC agreements, which had been fully reserved in 2019, were also forgiven as part of the settlement agreement and written off by the Company. Following the settlement agreement, these Harvest start-up entities are no longer related parties.
The Company has previously entered into strategic collaborations, including ECCs and JVs, to fund and develop products enabled by its technologies. These relationships involve complex interests, and the Company's interests may diverge with those of its collaborators, which can occur as a result of operations under those collaborations, business or technological developments, or as the Company transitions away from, or terminates, certain strategic collaborations. The Company has had, and has, disagreements and disputes with certain collaborators and JV partners, including the IEP Investors and the IEPII Investors. While the Company believes it is entitled to payment for work performed per its collaborations and JVs, consistent with its policy for accounting for accounts receivable, in 2019, the Company has fully reserved the amount of any disputed accounts receivable that remained outstandingoutstanding.
On December 29, 2021, the Company received a letter from a group of investors in each of Intrexon Energy Partners and Intrexon Energy Partners II, purporting to refer certain issues to arbitration pursuant to the arbitration provisions of the Amended and Restated Limited Liability Company Agreements of Intrexon Energy Partners and Intrexon Energy Partners II (the “Arbitration Matters”). On January 25, 2022, the Company filed a petition in the Court of Chancery for the State of Delaware seeking to enjoin the arbitration proceeding. In March 2022, the Court of Chancery for the State of Delaware determined that arbitration should proceed. The structure of the arbitration requires each party to propose terms for resolution of each matter and the arbitration panel will be required to award one of the two proposals for each matter without compromise. The Company has proposed terms that the Company would acquire the membership interests of the IEP Investors in exchange of $5,000, and the membership interests of the IEPII Investors in exchange of $2,000. The investor group has proposed terms that the Company would acquire the membership interests of each individual investor in exchange of $34,000 for the membership interests of the IEP Investors and $12,000 for the membership interests of the IEPII Investors, representing the purchase price of their original investments, as well as, in addition, accrued interest from the date of their original investments, which approximates $18,000 for the IEP Investors and $6,000 for the IEPII Investors. The Company expects the arbitration will
27

Table of Contents
be concluded in the second quarter of 2022. While the Company believes the investor groups’ claims are without merit, there can be no assurance that the panel will award the Company’s proposal and will not award the investors’ proposal with respect to either of the Arbitration Matters. In addition, as disclosed in Note 5, as of June 30, 2021. TheseMarch 31, 2022, the Company has a deferred revenue liability of $21,205 related to consideration previously received from Intrexon Energy Partners and Intrexon Energy Partners II that will be re-evaluated upon conclusion of the Arbitration Matters.
Such disagreements and disputes result in management distraction and may result in further litigation, arbitration, unfavorable settlements, or concessions by the Company, or adverse regulatory action, any of which could harm the Company's business or operations.
In the course of its business, the Company is involved in litigation or legal matters, including governmental investigations. Such matters are subject to many uncertainties and outcomes are not predictable with assurance. The Company accrues liabilities for such matters when it is probable that future expenditures will be made and such expenditures can be reasonably estimated. As
31

Table of Contents
of June 30, 2021,March 31, 2022, the Company does not believe that any such matters, individually or in the aggregate, will have a material adverse effect on the Company's business, financial condition, results of operations, or cash flows.
17. Related Party Transactions
Third Security and Affiliates
The Company's Executive Chairman is also the Senior Managing Director and Chairman of Third Security and owns 100% of the equity interests of Third Security. The Company hashad an agreement with Third Security under which the Company reimbursesreimbursed Third Security for certain tax-related services performed by Third Security as requested by the Company. The Company also reimburses Third Security for certain out-of-pocket expenses incurred on the Company's behalf. The agreement with Third Security expired on December 31, 2021. As the Company evaluates its alternatives, it continues to utilize these services on a limited basis under the terms of the original agreement. The total expenses incurred by the Company under these arrangements were $5$26 and $38$41 for the three months ended June 30,March 31, 2022 and 2021, and 2020, respectively, and $46 and $76 for the six months ended June 30, 2021 and 2020, respectively.
See also Note 14 regarding compensation arrangements between the Company and its Executive Chairman.
TheThrough November 2021, the Company also subleasessubleased certain administrative offices to Third Security. The significant terms of the lease mirrormirrored the terms of the Company's lease with the landlord, and the Company recorded sublease income of $21 and $24$20 for the three months ended June 30, 2021 and 2020, respectively, and $41 and $46 for the six months ended June 30, 2021 and 2020, respectively.March 31, 2021.
See Notes 1, 3, and 13 regarding additional transactions with affiliates of Third Security.
Transactions with ECC Parties
Collaborators in which the Company holds more than a de minimis equity interest, including interests received as upfront or milestone payments through collaborations, are considered related parties. The Company held Series A Convertible Preferred Stock (the "Convertible Preferred Shares"), a convertible note, common shares of Castle Creek, and warrants to purchase shares of Castle Creek common stock previously acquired through collaborations and other transactions. As a result of the acquisition of Castle Creek by Castle Creek Pharmaceutical Holdings, Inc. ("Castle Creek Pharmaceutical") in December 2019, the Company received $1,280 in December 2019 for its shares of Castle Creek common stock and received a total of $3,311 in January 2020 for the Convertible Preferred Shares and the convertible note, including accrued interest thereon. Subsequent to the acquisition by Castle Creek Pharmaceutical, Castle Creek is no longer a related party.
18. Net Loss per Share
The following table presents the computation of basic and diluted net income (loss) per share:
 Three Months Ended 
 June 30,
Six Months Ended 
 June 30,
 2021202020212020
Historical net loss per share:
Numerator:
Net loss from continuing operations$(20,063)$(15,709)$(41,907)$(36,555)
Net income (loss) from discontinued operations13 (27,645)4,539 (62,797)
Net loss$(20,050)$(43,354)$(37,368)$(99,352)
Denominator:
Weighted average shares outstanding, basic and diluted199,021,587 164,065,087 196,275,820 162,201,915 
Net loss per share:
Net loss from continuing operations per share, basic and diluted$(0.10)$(0.10)$(0.21)$(0.23)
Net income (loss) from discontinued operations per share, basic and diluted(0.16)0.02 (0.38)
Net loss per share, basic and diluted$(0.10)$(0.26)$(0.19)$(0.61)
32

Table of Contents
The following potentially dilutive securities as of June 30, 2021 and 2020, have been excluded from the above computations of diluted weighted average shares outstanding for the three and six months then ended as they would have been anti-dilutive:
June 30,
20212020
Convertible debt11,732,440 24,750,914 
Options12,660,387 11,383,039 
Restricted stock units554,146 1,897,181 
Warrants121,888 133,264 
Total25,068,861 38,164,398 
19. Segments
The Company's CODM assesses the operating performance of and allocates resources for several operating segments using Segment Adjusted EBITDA.EBITDA as a basis. Management believes this financial metric is a key indicator of operating results since it excludes noncash revenues and expenses that are not reflective of the underlying business performance of an individual enterprise. The Company defines Segment Adjusted EBITDA as net income (loss) before (i) interest expense, (ii) income tax expense or benefit, (iii) depreciation and amortization, (iv) stock-based compensation expense, (v) loss on settlement agreements where noncash consideration is paid, (vi) adjustments for accrued bonuses paid in equity awards, (vii) gain or loss on disposals of assets, (viii) loss on impairment of goodwill and other noncurrent assets, (ix) equity in net loss of affiliates, and (x) recognition of previously deferred revenue associated with upfront and milestone payments as well as cash outflows from capital expenditures and investments in affiliates, but includes proceeds from the sale of assets in the period sold. During the six months ended June 30, 2021, the Company modified the definition of Segment Adjusted EBITDA to exclude the gain or loss on disposals of assets and include proceeds from the sale of assets in the period sold. Segment Adjusted EBITDA for the three and six months ended June 30, 2020 was restated to reflect this change.
Because the Company uses Segment Adjusted EBITDA as its primary measure of segment performance, it has included this measure in its discussion of segment operating results. The Company has also disclosed revenues from external customers and intersegment revenues for each reportable segment. Corporate expenses are not allocated to the segments and are managed at a consolidated level. The CODM does not use total assets by segment to evaluate segment performance or allocate resources, and accordingly, these amounts are not required to be disclosed. The Company's segment presentation excludes amounts related to the businesses included in the Transactions and the operations of MBP Titan which are reported as discontinued operations (Note 3).
For the three and six months ended June 30, 2021,March 31, 2022, the Company's reportable segments were (i) Biopharmaceuticals, (ii) Exemplar, and (iii) Trans Ova. These identified reportable segments met the quantitative thresholds to be reported separately for the sixthree months ended June 30, 2021.March 31, 2022. See Note 2 for a description of Biopharmaceuticals. See Note 1 for a description of Exemplar and Trans Ova.
3328

Table of Contents
Segment Adjusted EBITDA by reportable segment was as follows:
Three Months Ended 
 June 30,
Six Months Ended 
 June 30,
Three Months Ended 
 March 31,
202120202021202020222021
BiopharmaceuticalsBiopharmaceuticals$(12,540)$(7,323)$(21,394)$(17,345)Biopharmaceuticals$(11,620)$(8,854)
ExemplarExemplar1,889 607 3,695 857 Exemplar3,558 1,806 
Trans OvaTrans Ova12,012 8,125 18,433 7,668 Trans Ova5,397 6,421 
Segment Adjusted EBITDA for reportable segmentsSegment Adjusted EBITDA for reportable segments$1,361 $1,409 $734 $(8,820)Segment Adjusted EBITDA for reportable segments$(2,665)$(627)
The table below reconciles Segment Adjusted EBITDA for reportable segments to consolidated net loss from continuing operations before income taxes:
Three Months Ended 
 June 30,
Six Months Ended 
 June 30,
Three Months Ended 
 March 31,
202120202021202020222021
Segment Adjusted EBITDA for reportable segmentsSegment Adjusted EBITDA for reportable segments$1,361 $1,409 $734 $(8,820)Segment Adjusted EBITDA for reportable segments$(2,665)$(627)
Remove cash paid for capital expenditures, net of proceeds from sale of assets, and cash paid for investments in affiliatesRemove cash paid for capital expenditures, net of proceeds from sale of assets, and cash paid for investments in affiliates801 1,026 1,398 3,151 Remove cash paid for capital expenditures, net of proceeds from sale of assets, and cash paid for investments in affiliates1,314 597 
Add recognition of previously deferred revenue associated with upfront and milestone paymentsAdd recognition of previously deferred revenue associated with upfront and milestone payments379 5,573 686 18,046 Add recognition of previously deferred revenue associated with upfront and milestone payments1,446 307 
Other expenses:Other expenses:Other expenses:
Interest expenseInterest expense(4,667)(4,592)(9,206)(9,184)Interest expense(2,069)(4,539)
Depreciation and amortizationDepreciation and amortization(3,520)(3,779)(7,043)(7,578)Depreciation and amortization(3,292)(3,523)
Loss on disposals of assetsLoss on disposals of assets(114)(761)(235)(978)Loss on disposals of assets(125)(121)
Impairment lossesImpairment losses(543)(543)Impairment losses(482)— 
Stock-based compensation expenseStock-based compensation expense(3,557)(4,981)(8,972)(10,621)Stock-based compensation expense(3,562)(5,415)
Adjustment related to accrued bonuses paid in equity awardsAdjustment related to accrued bonuses paid in equity awards2,833 Adjustment related to accrued bonuses paid in equity awards1,698 — 
Equity in net loss of affiliatesEquity in net loss of affiliates(251)(3)(602)Equity in net loss of affiliates(1)(3)
OtherOther(7)(14)12 Other— (7)
Unallocated corporate costsUnallocated corporate costs(10,052)(7,812)(18,246)(18,650)Unallocated corporate costs(10,060)(8,194)
EliminationsEliminations(204)(1,664)(575)(4,244)Eliminations(1,511)(371)
Consolidated net loss from continuing operations before income taxesConsolidated net loss from continuing operations before income taxes$(20,123)$(15,829)$(42,019)$(36,635)Consolidated net loss from continuing operations before income taxes$(19,309)$(21,896)
Revenues by reportable segment were as follows:
Three Months Ended June 30, 2021Three Months Ended March 31, 2022
BiopharmaceuticalsExemplarTrans OvaTotalBiopharmaceuticalsExemplarTrans OvaTotal
Revenues from external customersRevenues from external customers$416 $3,399 $29,765 $33,580 Revenues from external customers$84 $5,429 $26,508 $32,021 
Intersegment revenuesIntersegment revenues87 91 178 Intersegment revenues1,446 — 147 1,593 
Total segment revenuesTotal segment revenues$503 $3,399 $29,856 $33,758 Total segment revenues$1,530 $5,429 $26,655 $33,614 
Three Months Ended June 30, 2020Three Months Ended March 31, 2021
BiopharmaceuticalsExemplarTrans OvaTotalBiopharmaceuticalsExemplarTrans OvaTotal
Revenues from external customersRevenues from external customers$4,460 $2,105 $23,845 $30,410 Revenues from external customers$178 $3,257 $21,076 $24,511 
Intersegment revenuesIntersegment revenues1,513 90 1,603 Intersegment revenues241 — 107 348 
Total segment revenuesTotal segment revenues$5,973 $2,105 $23,935 $32,013 Total segment revenues$419 $3,257 $21,183 $24,859 
3429

Table of Contents
Six Months Ended June 30, 2021
BiopharmaceuticalsExemplarTrans OvaTotal
Revenues from external customers$594 $6,656 $50,841 $58,091 
Intersegment revenues328 198 526 
Total segment revenues$922 $6,656 $51,039 $58,617 
Six Months Ended June 30, 2020
BiopharmaceuticalsExemplarTrans OvaTotal
Revenues from external customers$15,322 $4,256 $40,630 $60,208 
Intersegment revenues3,602 199 3,801 
Total segment revenues$18,924 $4,256 $40,829 $64,009 

The table below reconciles total segment revenues from reportable segments to total consolidated revenues:
Three Months Ended 
 June 30,
Six Months Ended 
 June 30,
Three Months Ended 
 March 31,
202120202021202020222021
Total segment revenues from reportable segmentsTotal segment revenues from reportable segments$33,758 $32,013 $58,617 $64,009 Total segment revenues from reportable segments$33,614 $24,859 
Other revenues13 54 
Elimination of intersegment revenuesElimination of intersegment revenues(178)(1,602)(526)(3,801)Elimination of intersegment revenues(1,593)(348)
Total consolidated revenuesTotal consolidated revenues$33,580 $30,424 $58,091 $60,262 Total consolidated revenues$32,021 $24,511 

For the three months ended March 31, 2022 and 2021,13.0% and 8.4%, respectively, of total consolidated revenue was attributable to one customer in the Exemplar segment.
As of June 30, 2021March 31, 2022 and December 31, 2020,2021, the Company had $5,260$4,148 and $5,908,$4,463, respectively, of long-lived assets in foreign countries. The Company recognized revenues derived in foreign countries totaling $251$205 and $122$99 for the three months ended June 30,March 31, 2022 and 2021, and 2020, respectively, and $350 and $363 for the six months ended June 30, 2021 and 2020, respectively.
3530

Table of Contents
Item 2. Management's Discussion and Analysis of Financial Condition and Results of Operations
The following "Management's Discussion and Analysis of Financial Condition and Results of Operations" should be read in conjunction with the unaudited financial information and the notes thereto included in this Quarterly Report on Form 10-Q, or Quarterly Report, and our Annual Report on Form 10-K for the year ended December 31, 2020,2021, or Annual Report.
The following discussion contains forward-looking statements that reflect our plans, estimates, expectations, and beliefs. Our actual results could differ materially from those discussed in the forward-looking statements and you are cautioned not to place undue reliance on forward-looking statements. Factors that could cause or contribute to these differences include those discussed below and elsewhere in this Quarterly Report, particularly in "Special Note Regarding Forward-Looking Statements" and "Risk Factors." The forward-looking statements included in this Quarterly Report are made only as of the date hereof.
Overview

We are a dedicated discovery and clinical-stage biopharmaceutical company advancing the next generation of gene and cell therapies with the overall goal of improving outcomes for patients with significant unmet medical needs. We are leveraging our proprietary technology platforms to develop product candidates designed to target urgent and intractable diseases in our core therapeutic areas of immuno-oncology, autoimmune disorders, and infectious diseases. We have developed an extensive pipeline of therapies across multiple indications within these core focus areas.

We believe that our array of technology platforms uniquely positions us among other biotechnology companies to advance precision medicine. Precision medicine is the practice of therapeutic product development that takes into account specific genetic variations within populations impacted by a disease to design targeted therapies to improve outcomes for a disease or patient population. Our proprietary and complementary technology platforms provide a strong foundation to realize the core promise of precision medicine by supporting our efforts to construct powerful gene programs to drive efficacy, deliver these programs through viral, non-viral, and microbe-based approaches to drive lower costs, and control gene expression to drive safety. Our therapeutic platforms, including UltraCAR-T, AdenoVerse immunotherapy, and ActoBiotics, are designed to allow us to precisely control the level and physiological location of gene expression and modify biological molecules to control the function and output of living cells to treat underlying disease conditions.

We are actively advancing our lead clinical programs, including: PRGN-3005 and PRGN-3006, which are built on our UltraCAR-T platform; and PRGN-2009 and PRGN-2012, which are based on our AdenoVerse immunotherapy platform; and AG019, which is built on our ActoBiotics platform. In addition, we have completed a Phase 11b/2a study of INXN-4001, a non-viral triple-effector plasmid DNA,AG019, which is built on our UltraVectorActoBiotics platform. We also have a robust pipeline of preclinical programs that we are pursuing in order to drive long-term value creation.

We have developed a proprietary electroporation device, UltraPorator, designed to further streamline and ensure the rapid and cost-effective manufacturing of UltraCAR-T therapies. In October 2020, we announced that UltraPorator has received U.S. Food and Drug Administration, or FDA, clearance for manufacturing UltraCAR-T cells in clinical trials, and insince November 2020, we announced that we have begunbeen dosing patients with UltraCAR-T cells manufactured with UltraPorator in our PRGN-3005 and PRGN-3006 clinical trials.

We exercise discipline in our portfolio management by systematically evaluating data from our preclinical programs in order to make rapid "go" and "no go" decisions. Through this process, we believe we can more effectively allocate resources to programs that we believe show the most promise and advance such programs to clinical trials.
Our Healthcare Business

Our healthcare business focuses on human therapeutics and developing research models and services for healthcare research applications. Our Biopharmaceuticals segment includes our wholly owned subsidiaries PGEN Therapeutics, Inc., or PGEN Therapeutics, and Precigen ActoBio, Inc., or ActoBio, and our majority ownership interest in Triple-Gene LLC, doing business as Precigen Triple-Gene, or Triple-Gene, as well as royalty interests in therapeutics and therapeutic platforms from companies not controlled by us. Exemplar Genetics LLC, doing business as Precigen Exemplar, or Exemplar, is a wholly owned subsidiary which is focused on developing research models and services for healthcare research applications.
36

Table of Contents
Biopharmaceuticals
PGEN Therapeutics
PGEN Therapeutics is a dedicated discovery and clinical stage biopharmaceutical company advancing the next generation of gene and cell therapies using precision technology to target urgent and intractable diseases in immuno-oncology, autoimmune
31

Table of Contents
disorders and infectious diseases. PGEN Therapeutics operates as an innovation engine, progressing a preclinical and clinical pipeline of well-differentiated therapies toward clinical proof-of-concept and commercialization.

PGEN Therapeutics is developing therapies primarily built on our UltraCAR-T therapeutics platform and our "off-the-shelf" AdenoVerse immunotherapy platform. Through our UltraCAR-T therapeutics platform, we are able to precision-engineer UltraCAR-T cells to produce a homogeneous cell product that simultaneously expresses antigen-specific chimeric antigen receptor, or CAR, kill switch, and our proprietary membrane-bound interleukin-15, or mbIL15, genes in any genetically modified UltraCAR-T cell. Our decentralized and rapid proprietary manufacturing process allows us to manufacture UltraCAR-T cells overnight at a medical center's current good manufacturing practices facility, or cGMP, and reinfuse the patient the following day after gene transfer. This process improves upon current approaches to CAR-T manufacturing, which require extensive ex vivo expansion following viral vector transduction to achieve clinically relevant cell numbers that we believe can result in the exhaustion of CAR-T cells prior to their administration, limiting their potential for persistence in patients. We have developed a proprietary electroporation device, UltraPorator, designed to further streamline and ensure the rapid and cost-effective manufacturing of UltraCAR-T therapies. The UltraPorator system includes proprietary hardware and software solutions and potentially represents major advancements over current electroporation devices by significantly reducing the processing time and contamination risk. UltraPorator is intended to be a viable scale-up and commercialization solution for decentralized UltraCAR-T manufacturing. Our AdenoVerse immunotherapy platform utilizes a library of proprietary adenovectors for the efficient gene delivery of therapeutic effectors, immunomodulators, and vaccine antigens. We have established proprietary manufacturing cell lines and production methodologies from our AdenoVerse immunotherapy platform, which we believe are easily scalable for commercial supply. We believe that our proprietary gorilla adenovectors, part of the AdenoVerse technology, have superior performance characteristics as compared to current competition, including standard human adenovirus serotype 5, rare human adenovirus types and other non-human primate adenovirus types.

The most advanced programs within PGEN Therapeutics are as follows:

PRGN-3005 is a first-in-class, investigational autologous CAR-T therapy that utilizes our UltraCAR-T platform to simultaneously express a CAR targeting the unshed portion of the Mucin 16 antigen, mbIL15, and kill switch genes. PRGN-3005 is currently being evaluated in a Phase 1/1b clinical trial for the treatment of advanced, recurrent platinum-resistant ovarian cancer,, fallopian tube, or primary peritoneal cancer. AIn January 2022, we announced the completion of enrollment in the dose escalation phase of both IP and IV arms without lymphodepletion in the intraperitoneal (IP) armongoing Phase 1 clinical trial. We have received FDA clearance to incorporate lymphodepletion at Dose Level 3 of the PRGN-3005 Phase 1 trial is ongoing, and an expansion phase is planned at the maximum tolerated dose, or MTD. A dose escalation phase of the intravenous (IV) arm of the PRGN-3005 trial is ongoing concurrently with the IPIV arm.

PRGN-3006 is a first-in-class, investigational autologous CAR-T therapy that utilizes our UltraCAR-T platform to express a CAR to target CD33 (Siglec-3), mbIL15 and akill switch genes.gene. PRGN-3006 is currently being evaluated in an investigator-initiateda Phase 1/1b clinical trial for the treatment of relapsed or refractory, or r/r, acute myeloid leukemia, or AML, higher-riskhigh-risk myelodysplastic syndromes, or MDS, and chronic myelomonocytic leukemia, or CMML. AIn January 2022, we announced the completion of enrollment in the dose escalation phase of each ofin both the non-lymphodepletion and the lymphodepletion armscohorts of this Phase 1 trialtrial. An expansion phase is ongoing concurrently. The dose escalation phase of each arm is planned to be followed by an expansion phase at the MTD. On April 4, 2022, we announced that PRGN-3006 was granted Fast Track designation in patients with r/r AML by the FDA. Previously PRGN-3006 was granted Orphan Drug designation for the treatment ofDesignation in patients with AML by the FDA.

PRGN-3007 is a first-in-class, investigational autologous CAR-T therapy that utilizes the next generation UltraCAR-T platform to express a CAR to target ROR1, mbIL15, kill switch, and a novel mechanism for the intrinsic blockade of the programmed death 1, or PD-1, gene expression. PRGN-3007 has received FDA clearance to initiate a Phase 1/1b clinical trial for patients with advanced receptor tyrosine kinase-like orphan receptor 1-positive, or ROR1+, hematological (Arm 1) and solid tumors (Arm 2). The target patient population for Arm 1 includes relapsed or refractory CLL, relapsed or refractory MCL, relapsed or refractory B-ALL, and relapsed or refractory DLBCL. The target patient population for Arm 2 includes locally advanced unresectable or metastatic histologically confirmed TNBC. The study will enroll in two parts: an initial 3+3 dose escalation in each arm followed by a dose expansion at the maximum tolerated dose. Arm 1 and Arm 2 will enroll in parallel.

PRGN-2009 is a first-in-class, "off-the-shelf" investigational immunotherapy designed to activate the immune system to recognize and target human papillomavirus-positive, or HPV+, solid tumors. PRGN-2009 leverages our UltraVector and AdenoVerse platforms to optimize HPV type 16 and HPV type 18, antigen design for delivery via a proprietary gorilla adenovector with a large genetic payload capacity and the ability for repeat administrations. PRGN-2009 is in a Phase 1/2 clinical trial as a monotherapy or in combination with bintrafusp alfa, or M7824, an investigational bifunctional fusion protein, for patients with HPV-associated cancers in collaboration with the National Cancer Institute, or NCI, pursuant to a cooperative research and development arrangement, or CRADA.

PRGN-2012 is a first-in-class, investigational "off-the-shelf" AdenoVerse immunotherapy for the treatment of recurrent respiratory papillomatosis, or RRP. PRGN-2012 is an innovative therapeutic vaccine with optimized antigen design that uses our gorilla adenovector technology, part of our proprietary AdenoVerse platform, to elicit immune responses directed against
32

Table of Contents
cells infected with HPV type 6 and HPV type 11. PRGN-2012 is in a Phase 11/2 clinical trial for adult patients with RRP. PRGN-2012 is being developed in collaboration with the Center for Cancer Research at the NCI pursuant to a CRADA. PRGN-2012 washas been granted Orphan Drug designation for treatment of RRP by the FDA.
37

Table of
Contents
In addition to our clinical programs, PGEN Therapeutics has a robust pipeline of preclinical programs in our core therapeutic areas of immune-oncology, infectious diseases, and autoimmune disorders that we are pursuing in order to drive long-term value creation. Our pipeline includes a number of product candidates, including UltraCAR-T therapeutics for various cancers, and "off-the-shelf" AdenoVerse immunotherapy for infectious disease, and a multifunctional therapeutic for solid tumors.platforms. We expect to continue development of various preclinical programs to identify product candidates for evaluation in clinical trials.
Precigen ActoBio, Inc.

ActoBio is pioneering a proprietary class of microbe-based biopharmaceuticals that enable expression and local delivery of disease-modifying therapeutics. We refer to these microbe-based biopharmaceuticals as ActoBiotics. Our ActoBiotics platform is a unique delivery platform precisely tailored for specific disease modification with the potential for superior efficacy and safety. ActoBiotics combine the advantages of highly selective protein-based therapeutic agents with local delivery by the well-characterized and food-grade bacterium Lactococcus lactis, or L. lactis. ActoBiotics can be delivered orally in a capsule, through an oral rinse, or in a topical solution. We believe ActoBiotics have the potential to provide superior safety and efficacy via the sustained release of appropriate quantities of select therapeutic agents as compared to injectable biologics, while reducing the side effects commonly attributed to systemic delivery and corresponding peaks in concentration.ActoBiotics work via genetically modified bacteria that deliver proteins and peptides at mucosal sites, rather than the insertion of one or more genes into a human cell by means of a virus or other delivery mechanism. By foregoing this insertion, ActoBiotics allow "gene therapy" without the need for cell transformation.

ActoBio's most advanced internal pipeline candidate, AG019, is a first-in-class disease modifying antigen-specific, investigational immunotherapy for the prevention, delay, or reversal of type 1 diabetes mellitus, or T1D. AG019 is an easy-to-take capsule formulation of ActoBiotics engineered to deliver the autoantigen human proinsulin, or PINS,hPINS, and the tolerance-enhancing cytokine human interleukin-10 to the mucosal lining of gastro-intestinal tissues in patients with T1D. AG019 is currently inWe have completed a Phase 1b/2a clinical trial of AG019 for the treatment of early-onset T1D. The Phase 1b portion of the study evaluatesevaluated the safety and tolerability of AG019 monotherapy administered as a single dose and repeated daily doses in adult and adolescent patients. The Phase 2a double-blind portion of the study investigatesinvestigated the safety and tolerability of AG019 in combination with teplizumab, or PRV-031. Enrollment and dosing in the Phase 1b and Phase 2a portions of the study are complete. The primary endpoint of assessing safety and tolerability in both the Phase 1b AG019 monotherapy and the Phase 2a AG019 combination armstherapy has been met. AG019 was well-tolerated when administered to adults and adolescents either as monotherapy or in combination with teplizumab. A single 8-week treatment cycle of the study was met. No dose-related adverse eventsoral AG019 as a monotherapy and in combination with teplizumab showed stabilization or serious adverse events were reported in either portionincrease of this trial. Interim data presented showed an encouraging trend in C-peptide levels a biomarker for T1D disease progression, at six months after AG019 monotherapy treatment initiation. Furthermore, AG019 monotherapy induced antigen-specific tolerance in conjunction withduring the reduction of disease-specific T cell responses sixfirst 6 months post treatment initiation. Data from the Phase 2a portion showed that the combination was well-tolerated and the preliminary data at six months after treatment initiation showed an encouraging trend in C-peptide levels compared to baseline levels. The combination of AG019 and teplizumab showed the induction of antigen-specific tolerance in conjunction with reduction of disease-specific T cell responses at six months post treatment initiation.recent-onset T1D.
Precigen Triple-Gene

Triple-Gene is a clinical stage gene therapy company focused on developing advanced treatments for complex cardiovascular diseases. Triple-Gene's approach is to develop a holistic treatment for heart failure through improvements in angiogenesis, calcium homeostasis-associated cellular energetics, reductions in inflammatory signals, and the activation/recruitment of stem cells to support heart remodeling. Triple-Gene's most advanced candidate, INXN-4001, a non-viral triple-effector plasmid based on our UltraVector platform designed for constitutive expression of human S100A1, SDF-1a, and VEGF-165,VEGF-165. INXN-4001 is engineered to address multiple pathways of heart failure. Utilizing a single plasmid comprising all three genes, instead of each individual gene on separately delivered plasmids, INXN-4001 can control for delivery and ensure expression of the three genes in all transfected cells. A

We have completed a first-in-human, open label Phase 1 trialstudy designed to evaluate the safety of retrograde coronary sinus infusion, or RCSI, of INXN-4001 in outpatient left ventricular assist device, or LVAD, recipients has been completed. Six-month follow-up data demonstrated that the studyrecipients.The Phase 1 trial met the primary endpoints to evaluate safety and feasibility for INXN-4001.
Partnered Program

We have partnered with Castle Creek Biosciences, Inc., or Castle Creek, to advance product candidates D-Fi (debcoemagene autoficel), formerly designated FCX-007, for the treatment of recessive dystrophic epidermolysis bullosa, or RDEB, and FCX-013 for the treatment of localized scleroderma. In October 2020, Castle Creek announced the dosing of the first patient in the ongoing Phase 3 trial of D-Fi and the dosing of the first patient in the ongoing Phase 1/2 trial of FCX-013. The FDA has granted Orphan Drug designation to D-Fi for the treatment of Dystrophic Epidermolysis Bullosa, which includes RDEB. In addition, D-Fi has been granted Rare Pediatric Disease designation, Fast Track designation, and Regenerative Medicine Advanced Therapy designation by the FDA for treatment of RDEB. The FDA has granted Orphan Drug designation to
33

Table of Contents
FCX-013 for the treatment of localized scleroderma. In addition, FCX-013 has been granted Rare Pediatric Disease designation and Fast Track designation for the treatment of moderate to severe localized scleroderma. Pursuant to the collaboration, we licensed our technology platforms to Castle Creek for use in certain specified fields, and in exchange, we received and were
38

Table of Contents
entitled to certain access fees, milestone payments, royalties, and sublicensing fees related to the development and commercialization of product candidates. In March 2020, we and Castle Creek terminated the original collaboration agreement by mutual agreement, with the parties agreeing that FCX-007 and FCX-013 would be treated as "Retained Products" under the terms of the original agreement. Castle Creek retains a license to continue to develop and commercialize the Retained Products within the field of use for so long as Castle Creek continues to pursue such development and commercialization, and we are also entitled to certain royalties with respect to the Retained Products. We are also required to perform certain drug product manufacturing activities related to the Retained Products.
Precigen Exemplar

Exemplar is committed to enabling the study of life-threatening human diseases through the development of MiniSwine Yucatan miniature pig research models and services, as well as enabling the production of cells and organs in its genetically engineered swine for regenerative medicine applications. Historically, researchers have lacked animal models that faithfully represent human diseases. As a result, a sizeable barrier has blocked progress in the discovery of human disease mechanisms; novel diagnostics, procedures, devices, prevention strategies and therapeutics; and the ability to predict in humans the efficacy of those next-generation procedures, devices, and therapeutics. Exemplar's MiniSwine models are genetically engineered to exhibit a wide variety of human disease states, which provides a more accurate platform to test the efficacy of new medications and devices.
Our Non-Healthcare Business
At June 30, 2021,March 31, 2022, our only non-healthcare business is our established bovine genetics company, Trans Ova Genetics, L.C., or Trans Ova.
Trans Ova

Trans Ova is internationally recognized as a provider of industry-leading bovine reproductive technologies. Trans Ova offers bovine embryo transfer technologies, in addition to other advanced reproductive technologies, including in vitro fertilization, or IVF, sexed-semen, genetic preservation, and cloning. Through extensive research programs and applied science, Trans Ova has developed and implemented new technologies that, we believe, have helped to move the science of bovine genetic improvement forward. We continueare evaluating strategic alternatives to evaluatedetermine the optimal means to utilize these technology assets and Trans Ova's broad customer base and deep industry knowledge to maximize the value of the business.business for our shareholders, including a potential sale of the business, the development of collaborations with third parties, and other strategic opportunities.
COVID-19 Impact
COVID-19 has had and continues to have an extensive impact on the global health and economic environments.
The health and safety of our employees is of the utmost importance. Our essential employees are practicing appropriate safety measures, including social distancing and use of personal protective equipment. These efforts have permitted us to continue to advance our programs, with the ultimate goal of benefiting patients.
Commencing in the second half of March 2020, our healthcare business began to experience delays to certain of our clinical trials as a result of COVID-19. For example, starting in March 2020, we temporarily suspended the last cohort of the Phase 1b/2a clinical trial for AG019 as a proactive measure to protect the welfare and safety of patients, caregivers, clinical site staff, our employees, and contractors. The temporary suspension of the AG019 trial was voluntary and was not related to any patient safety issues in the study. The voluntary suspension of the AG019 trial was lifted in June 2020, and recruitment in the study resumed. Additionally, from April to May 2020, enrollment of new patients in our PRGN-3005 Phase 1 trial was temporarily suspended due to a mandated hold on certain early and late-stage clinical trials at the Fred Hutchinson Cancer Research Center in Seattle that was instituted in light of the COVID-19 pandemic. Recruitment resumed in the PRGN-3005 trial in May 2020. Although these suspensions did not result in significant overall delay,Furthermore, there is uncertainty regarding the duration and severity of the ongoing pandemic, and we could experience further delays of other pandemic-related events that may adversely impact our clinical as well as preclinical pipeline candidates in the future.
Notwithstanding the foregoing, as the COVID-19 pandemic continues to evolve, we may experience additional delays to our clinical trials, including related to enrollment, site closures, reduced availability of key personnel, or our ability to receive the necessary approvals from the FDA or other regulatory agencies to advance our programs.
We are also closely monitoring the impact of COVID-19 on otherall aspects of our business. While Trans Ova and Exemplar have not experienced any significant impacts as a result of COVID-19 at this time, we are unable to reliably quantify or estimate what the future impacts may be.
39

Table of Contents
businesses. Given the dynamic nature of these circumstances, the full impact of the COVID-19 pandemic on our ongoing business, results of operations, and overall financial performance cannot be reasonably estimated at this time.

The health and safety of our employees is of the utmost importance. We have implemented safety measures in our facilities for the well-being of our employees and visitors. These measures have permitted us to continue to advance our programs, with the ultimate goal of benefiting patients.

For more information regarding the risks associated with COVID-19 and its impact on our business, see "Risk Factors" in Part II - Item 1A.
34

Table of Contents
Discontinued Operations
Historically, we developed technology platforms for application across a variety of diverse end markets, including health, food, energy, and the environment. In January 2020, we announced that we were increasing our focus on our healthcare opportunities, which reflected our most advanced platforms, and in connection therewith, we divested a number of our non-healthcare assets (referred to collectively as the Transactions) and changed our name to Precigen, Inc.
In 2020, as a result of market uncertainty driven by the COVID-19 pandemic and the state of the energy sector raising significant challenges for the strategic alternatives pursued by MBP Titan, LLC, or MBP Titan, our methane bioconversion business, we suspended MBP Titan's operations, preserved certain of MBP Titan's intellectual property, terminated all of its personnel, and undertook steps to dispose of its other assets and obligations. The wind down of MBP Titan's activities was substantially complete by December 31, 2020, with the final disposition of certain property and equipment and the facility operating lease occurring in January 2021. This discontinuation of operations represented the continuation of a strategic shift that we commenced in early 2020 to becoming a primarily healthcare company advancing technologies and products that address complex healthcare challenges. After the wind down of MBP Titan, certain assets and contractual obligations which were originally related to MBP Titan continue to be managed at the Precigen corporate level. These remaining assets and contractual obligations include our equity interests in and collaboration agreements with Intrexon Energy Partners, LLC, or Intrexon Energy Partners, and Intrexon Energy Partners II, LLC, or Intrexon Energy Partners II, including the associated deferred revenue remaining under each collaboration agreement, as well as the associated intellectual property.
See also "Notes to the Condensed Consolidated Financial Statements (Unaudited) - Note 3" appearing elsewhere in this Quarterly Report for additional discussion of our discontinued operations.
See "Notes to the Condensed Consolidated Financial Statements (Unaudited) - Note 4" appearing elsewhere in this Quarterly Report for a discussion of Intrexon Energy Partners and Intrexon Energy Partners II.
Segments
As of June 30, 2021,March 31, 2022, our reportable segments were (i) Biopharmaceuticals, (ii) Exemplar, and (iii) Trans Ova. These identified reportable segments met the quantitative thresholds to be reported separately for the sixthree months ended June 30, 2021.March 31, 2022.
Corporate expenses, which are not allocated to the segments and are managed at a consolidated level, include costs associated with general and administrative functions, including our finance, accounting, legal, human resources, information technology, corporate communication, and investor relations functions. Corporate expenses exclude interest expense, depreciation and amortization, gain or loss on disposals of assets, stock-based compensation expense, loss on settlement agreement, and equity in net loss of affiliates. See "Notes to the Condensed Consolidated Financial Statements (Unaudited) - Note 19"18" appearing elsewhere in this Quarterly Report for a discussion of our reportable segments and Segment Adjusted EBITDA.
Financial overview
We have incurred significant losses since our inception. We anticipate that we may continue to incur significant losses for the foreseeable future, and we may never achieve or maintain profitability. Our historical collaboration and licensing revenues were generated under a business model from which we have gradually transitioned, and we do not expect to expend significant resources servicing our historical collaborations in the future. We may enter into strategic transactions for individual platforms or programs in the future from which we may generate new collaboration and licensing revenues. We continue to generate product and service revenues through our Trans Ova and Exemplar subsidiaries, and in the sixthree months ended June 30, 2021,March 31, 2022, both of these subsidiaries generated positive Segment Adjusted EBITDA. Products currently in our clinical pipeline will require regulatory approval and/or commercial scale-up before they may commence significant product sales and operating profits.
As we continue our efforts to focus our business and generate additional capital, we may be willing to enter into transactions involving one or more of our operating segments and reporting units for which we have goodwill and intangible assets. These efforts could result in us identifying impairment indicators or recording impairment charges in future periods. In addition, market changes and changes in judgements, assumptions, and estimates that we have made in assessing the fair value of goodwill could cause us to consider some portion or all of certain assets to become impaired.
4035

Table of Contents
Sources of revenue
Historically, we have derived our collaboration and licensing revenues through agreements with counterparties for the development and commercialization of products enabled by our technologies. Generally, the terms of these collaborations provide that we receive some or all of the following: (i) technology access fees upon signing; (ii) reimbursements of costs incurred by us for our research and development and/or manufacturing efforts related to specific applications provided for in the collaboration; (iii) milestone payments upon the achievement of specified development, regulatory and commercial activities; and (iv) royalties on sales of products arising from the collaboration.
Our technology access fees and milestone payments may be in the form of cash or securities of the collaborator. Our collaborations contain multiple arrangements, and we typically defer revenues from the technology access fees and milestone payments received and recognize such revenues in the future over the anticipated performance period. We are also entitled to sublicensing revenues in those situations where our collaborators choose to license our technologies to other parties.
As we continue to shift our focus on our healthcare business, we have and may continue to mutually terminate collaboration agreements or repurchase rights to the exclusive fields from collaborators, relieving us of any further performance obligations under the agreement. Upon such circumstances or when we determine no further performance obligations are required of us under an agreement, we may recognize any remaining deferred revenue as either collaboration revenue or as a reduction of operating expense, depending on the circumstances. See "Notes to the Condensed Consolidated Financial Statements (Unaudited) - Note 5" appearing elsewhere in the Quarterly Report for a discussion of changes to our significant collaborations.
We generate product and service revenues primarily through sales of products or services that are created from technologies developed or owned by us. Our primary current revenues arise from Trans Ova and include sales of advanced reproductive technologies, including our bovine embryo transfer and IVF processes and from genetic preservation and sexed semen processes, and applications of such processes to other livestock, as well as sales of livestock and embryos produced using these processes and used in production. Exemplar also generates product and service revenues through the development and sale of genetically engineered miniature swine models. We recognize revenue when control of the promised product is transferred to the customer or when the promised service is completed.
In future periods, in connection with our focus on healthcare, our revenues will primarily depend on our ability to advance and create our own programs and the extent to which we bring products enabled by our technologies to market. Other than for collaboration revenues recognized upon cancellation or modification of an existing collaboration or for revenues generated pursuant to future strategic transactions for any of our existing platforms or programs, we expect our collaboration revenues will continue to decrease in the near term. Our revenues will also depend upon our ability to maintain or improve the volume and pricing of Trans Ova's and Exemplar's current product and service offerings and to develop and scale up production of new offerings from the various technologies of our subsidiaries. As we focus on our healthcare business, we anticipate that our expenses will increase substantially if, and as, we continue to advance the preclinical and clinical development of our existing product candidates and our research programs. We expect a significant period of time could pass before commercialization of our various product candidates or before the achievement of contractual milestones and the realization of royalties on product candidates commercialized under our collaborations and revenues sufficient to achieve profitability. Accordingly, there can be no assurance as to the timing, magnitude, and predictability of revenues to which we might be entitled.
Cost of products and services
Cost of products and services includes primarily labor and related costs, drugs and supplies used primarily in Trans Ova's embryo transfer and IVF processes, livestock and feed used in production, and facility charges, including rent and depreciation. Fluctuations in the price of livestock and feed have not had a significant impact on our operating margins and no derivative financial instruments are used to mitigate the price risk.
Research and development expenses
We recognize research and development expenses as they are incurred. Our research and development expenses consist primarily of:
salaries and benefits, including stock-based compensation expense, for personnel in research and development functions;
fees paid to consultants and contract research organizations who perform research on our behalf and under our direction;
4136

Table of Contents
costs related to laboratory supplies used in our research and development efforts and acquiring, developing, and manufacturing preclinical study and clinical trial materials;
costs related to certain in-licensed technology rights or reacquired in-process research and development;
amortization of patents and related technologies acquired in mergers and acquisitions; and
facility-related expenses, which include direct depreciation costs and unallocated expenses for rent and maintenance of facilities and other operating costs.
Our research and development expenses are generally incurred by our reportable segments and primarily relate to either costs incurred to expand or otherwise improve our technologies or the costs incurred to develop our own products and services. Our Biopharmaceuticals segment is progressing preclinical and clinical programs that target urgent and intractable diseases in our core therapeutic areas of immuno-oncology, autoimmune disorders, and infectious diseases, including PRGN-3005, PRGN-3006, AG019,PRGN-2009, PRGN-2012, and INXN-4001.AG019. Exemplar's research and development activities relate to new and improved pig research models. Trans Ova's research and development activities support new and improved product and service offerings for its customers. The following table summarizes our research and development expenses incurred by reportable segment and reconciles those expenses to research and development expenses on the condensed consolidated statements of operations for the three and six months ended June 30, 2021March 31, 2022 and 2020.2021.
Three Months Ended 
 June 30,
Six Months Ended 
 June 30,
Three Months Ended 
 March 31,
2021202020212020 20222021
BiopharmaceuticalsBiopharmaceuticals$13,121 $8,897 $23,184 $19,538 Biopharmaceuticals$11,718 $10,063 
ExemplarExemplar63 161 137 351 Exemplar83 74 
Trans OvaTrans Ova502 454 887 1,094 Trans Ova961 385 
Total research and development expenses from reportable segmentsTotal research and development expenses from reportable segments13,686 9,512 24,208 20,983 Total research and development expenses from reportable segments12,762 10,522 
Other research and development expenses— (32)— (173)
EliminationsEliminations(5)(6)(6)(9)Eliminations(2)(1)
Total consolidated research and development expensesTotal consolidated research and development expenses$13,681 $9,474 $24,202 $20,801 Total consolidated research and development expenses$12,760 $10,521 
The amount of research and development expenses may be impacted by, among other things, the number and nature of our own proprietary programs, and the number and size of programs we may support on behalf of collaboration agreements. We expect that our research and development expenses will increase as we continue to develop our own proprietary programs, including progression of these programs into preclinical and clinical stages. We believe these increases will likely include increased costs paid to consultants and contract research organizations and increased costs related to laboratory supplies.
Research and development expenses may also increase as a result of in-licensing of technologies or ongoing research and development operations that we might assume through mergers and acquisitions.
Selling, general and administrative expenses
Selling, general and administrative, or SG&A, expenses consist primarily of salaries and related costs, including stock-based compensation expense, for employees in executive, operational, finance, information technology, legal, and corporate communications functions. Other significant SG&A expenses include rent and utilities, insurance, accounting, and legal services (including the cost of settling any claims and lawsuits), and expenses associated with obtaining and maintaining our intellectual property.
SG&A expenses may fluctuate in the future depending on the scaling of our corporate functions required to support our corporate initiatives and the outcomes of legal claims and assessments against us.
Other income (expense), net
Interest expense is expected to increase in future periods due to the noncash amortization of the long-term debt discount and debt issuance costs related to the 3.50% convertible senior notes due 2023 issued in July 2018.
42

Table of Contents
Interest income consists of interest earned on our cash and cash equivalents and short-term and long-term investments and may fluctuate based on amounts invested and current interest rates.
37

Table of Contents
Interest expense decreased in the current period, and is expected to decrease in future periods upon the adoption of a new accounting standard effective January 1, 2022, which simplified the accounting for the Convertible Notes. See "Notes to the Condensed Consolidated Financial Statements (Unaudited) - Note 2" appearing elsewhere in this Quarterly Report for further discussion.
Equity in net income (loss) of affiliates
Equity in net income or loss of affiliates is our pro-rata share of our equity method investments' operating results, adjusted for accretion of basis difference. We account for investments in our joint ventures, or JVs using the equity method of accounting since we have the ability to exercise significant influence, but not control, over the operating activities of these entities. We previously accounted for our investments in start-up entities backed by the Harvest Intrexon Enterprise Fund I, LP, or Harvest, using the equity method of accounting. In December 2020, we entered into an agreement with Harvest to resolve matters related to the parties' contractual and equity relationships and our remaining equity interests in start-up entities backed by Harvest were terminated.
Segment performance
We use Segment Adjusted EBITDA as our primary measure of segment performance. We define Segment Adjusted EBITDA as net income (loss) before (i) interest expense, (ii) income tax expense or benefit, (iii) depreciation and amortization, (iv) stock-based compensation expense, (v) loss on settlement agreements where noncash consideration is paid, (vi) adjustments for accrued bonuses paid in equity awards, (vii) gain or loss on disposals of assets, (viii) loss on impairment of goodwill and other noncurrent assets, (ix) equity in net loss of affiliates, and (x) recognition of previously deferred revenue associated with upfront and milestone payments as well as cash outflows from capital expenditures and investments in affiliates, but includes proceeds from the sale of assets in the period sold. Corporate expenses are not allocated to the segments and are managed at a consolidated level. See "Notes to the Condensed Consolidated Financial Statements (Unaudited) - Note 19"18" appearing elsewhere in this Quarterly Report for further discussion of Segment Adjusted EBITDA.
4338

Table of Contents
Results of operations
Comparison of the three months ended June 30, 2021March 31, 2022 and the three months ended June 30, 2020March 31, 2021
The following table summarizes our results of operations for the three months ended June 30,March 31, 2022 and 2021, and 2020, together with the changes in those items in dollars and as a percentage:
Three Months Ended 
 June 30,
Dollar
Change
Percent
Change
Three Months Ended 
 March 31,
Dollar
Change
Percent
Change
20212020 20222021
(In thousands)  (In thousands) 
RevenuesRevenuesRevenues
Collaboration and licensing revenues (1)Collaboration and licensing revenues (1)$301 $4,315 $(4,014)(93.0)%Collaboration and licensing revenues (1)$— $66 $(66)(100.0)%
Product revenuesProduct revenues8,335 8,540 (205)(2.4)%Product revenues8,724 6,381 2,343 36.7 %
Service revenuesService revenues24,803 17,381 7,422 42.7 %Service revenues23,209 17,931 5,278 29.4 %
Other revenuesOther revenues141 188 (47)(25.0)%Other revenues88 133 (45)(33.8)%
Total revenuesTotal revenues33,580 30,424 3,156 10.4 %Total revenues32,021 24,511 7,510 30.6 %
Operating expensesOperating expensesOperating expenses
Cost of productsCost of products6,135 8,141 (2,006)(24.6)%Cost of products7,510 5,574 1,936 34.7 %
Cost of servicesCost of services8,898 6,770 2,128 31.4 %Cost of services9,589 7,402 2,187 29.5 %
Research and developmentResearch and development13,681 9,474 4,207 44.4 %Research and development12,760 10,521 2,239 21.3 %
Selling, general and administrativeSelling, general and administrative19,997 17,869 2,128 11.9 %Selling, general and administrative19,576 18,702 874 4.7 %
Impairment of goodwillImpairment of goodwill482 — 482 N/A
Impairment of other noncurrent assets543 — 543 N/A
Total operating expensesTotal operating expenses49,254 42,254 7,000 16.6 %Total operating expenses49,917 42,199 7,718 18.3 %
Operating lossOperating loss(15,674)(11,830)(3,844)32.5 %Operating loss(17,896)(17,688)(208)1.2 %
Total other expense, netTotal other expense, net(4,449)(3,748)(701)18.7 %Total other expense, net(1,412)(4,205)2,793 (66.4)%
Equity in loss of affiliates— (251)251 (100.0)%
Equity in net loss of affiliatesEquity in net loss of affiliates(1)(3)(66.7)%
Loss from continuing operations before income taxesLoss from continuing operations before income taxes(20,123)(15,829)(4,294)27.1 %Loss from continuing operations before income taxes(19,309)(21,896)2,587 (11.8)%
Income tax benefitIncome tax benefit60 120 (60)(50.0)%Income tax benefit58 52 11.5 %
Loss from continuing operationsLoss from continuing operations(20,063)(15,709)(4,354)27.7 %Loss from continuing operations(19,251)(21,844)2,593 (11.9)%
Income (loss) from discontinued operations, net of income taxes (2)13 (27,645)27,658 100.0 %
Income from discontinued operations, net of income taxes (1)Income from discontinued operations, net of income taxes (1)— 4,526 (4,526)(100.0)%
Net lossNet loss$(20,050)$(43,354)$23,304 (53.8)%Net loss$(19,251)$(17,318)$(1,933)11.2 %
(1)Includes $0 and $32 from related parties for the three months ended June 30, 2021 and 2020, respectively.
(2)See "Notes to the Condensed Consolidated Financial Statements (Unaudited) - Note 3" appearing elsewhere in this Quarterly Report.
Collaboration and licensing revenues
Collaboration and licensing revenues decreased $4.0 million, or 93%, from the three months ended June 30, 2020 primarily due to a decrease in the recognition of previously deferred revenue in the current period resulting from fewer services being performed pursuant to a March 2020 termination agreement with Castle Creek.
Product revenues and gross margin
Product revenues were comparable to the three months ended June 30, 2020 as expected. Gross margin on products improved in the current period as a result of increased focus on selling higher margin products, and operational efficiencies that have been gained through reductions in workforce and improved inventory management.
44

Table of Contents
Service revenues and gross margin
Service revenues increased $7.4 million, or 43%, over the three months ended June 30, 2020. Trans Ova's revenues and gross margins thereon improved primarily due to an increase in services performed as a result of higher customer demand as the beef and dairy industries have been stronger in the current year and a change in pricing structure with certain customers. Additionally, Exemplar's service revenues and gross margins thereon improved in the current period due to an increase in services performed resulting from a higher demand from existing and new customers as well as a combination of price increases and a change in the pricing structure with certain customers.
Research and development expenses
Research and development expenses increased $4.2 million, or 44%, over the three months ended June 30, 2020. Contract research organization costs and lab supplies increased $3.8 million with the advancement of our clinical and preclinical programs.
Selling, general and administrative expenses
SG&A expenses increased $2.1 million, or 12%, over the three months ended June 30, 2020. Professional fees increased $1.8 million primarily due to an increase in legal fees associated with certain current litigation matters.
Segment performance
The following table summarizes Segment Adjusted EBITDA, which is our primary measure of segment performance, for the three months ended June 30, 2021 and 2020, for each of our reportable segments as well as unallocated corporate costs.
 Three Months Ended 
 June 30,
Dollar
Change
Percent
Change
 20212020
 (In thousands) 
Segment Adjusted EBITDA:
Biopharmaceuticals$(12,540)$(7,323)$(5,217)(71.2)%
Exemplar1,889 607 1,282 >200%
Trans Ova12,012 8,125 3,887 47.8 %
Unallocated corporate costs(10,052)(7,812)(2,240)28.7 %
For a reconciliation of Segment Adjusted EBITDA to net loss from continuing operations before income taxes, see "Notes to the Condensed Consolidated Financial Statements (Unaudited) - Note 19" appearing elsewhere in this Quarterly Report.
The following table summarizes revenues from external customers for the three months ended June 30, 2021 and 2020, for each of our reportable segments.
 Three Months Ended 
 June 30,
Dollar
Change
Percent
Change
 20212020
 (In thousands) 
Biopharmaceuticals$416 $4,460 $(4,044)(90.7)%
Exemplar3,399 2,105 1,294 61.5 %
Trans Ova29,765 23,845 5,920 24.8 %
Biopharmaceuticals
The decrease in revenues for Biopharmaceuticals was primarily due to a decrease in the recognition of previously deferred revenue in the current period resulting from fewer services being performed pursuant to a termination agreement with Castle Creek. Segment Adjusted EBITDA declined as we had increased costs associated with the advancement of our clinical and preclinical programs.
45

Table of Contents
Exemplar
Revenues for Exemplar increased due to an increase in services performed resulting from a higher demand from existing and new customers. Revenues also increased due to price increases as well as a change in the pricing structure with certain customers. The improvement in Segment Adjusted EBITDA was primarily due to the increased revenues and reduced costs as a result of operational efficiencies gained through reductions in workforce and improved inventory management.
Trans Ova
Revenues for Trans Ova increased primarily due to higher customer demand for pregnant cows and more procedures performed as a result of stronger beef and dairy industries in the current year. Revenues also increased due to a change in the pricing structure with certain customers. The improvement in Segment Adjusted EBITDA was primarily due to the increased revenues, as well as reduced costs as a result of operational efficiencies gained through reductions in workforce and improved inventory management.
Unallocated Corporate Costs
Unallocated corporate costs increased primarily due to increased professional fees associated with certain current litigation matters.
46

Table of Contents
Comparison of the six months ended June 30, 2021 and the six months ended June 30, 2020
The following table summarizes our results of operations for the six months ended June 30, 2021 and 2020, together with the changes in those items in dollars and as a percentage:
 Six Months Ended 
 June 30,
Dollar
Change
Percent
Change
 20212020
 (In thousands) 
Revenues
Collaboration and licensing revenues (1)$367 $15,036 $(14,669)(97.6)%
Product revenues14,716 13,501 1,215 9.0 %
Service revenues42,734 31,327 11,407 36.4 %
Other revenues274 398 (124)(31.2)%
Total revenues58,091 60,262 (2,171)(3.6)%
Operating expenses
Cost of products11,709 14,230 (2,521)(17.7)%
Cost of services16,300 14,306 1,994 13.9 %
Research and development24,202 20,801 3,401 16.4 %
Selling, general and administrative38,699 39,355 (656)(1.7)%
Impairment of other noncurrent assets543 — 543 N/A
Total operating expenses91,453 88,692 2,761 3.1 %
Operating loss(33,362)(28,430)(4,932)17.3 %
Total other expense, net(8,654)(7,603)(1,051)13.8 %
Equity in loss of affiliates(3)(602)599 (99.5)%
Loss from continuing operations before income taxes(42,019)(36,635)(5,384)14.7 %
Income tax benefit112 80 32 40.0 %
Loss from continuing operations(41,907)(36,555)(5,352)14.6 %
Income (loss) from discontinued operations, net of income taxes (2)4,539 (62,797)67,336 107.2 %
Net loss$(37,368)$(99,352)$61,984 (62.4)%
(1)Includes $0 and $230 from related parties for the six months ended June 30, 2021 and 2020, respectively.
(2)See "Notes to the Condensed Consolidated Financial Statements (Unaudited) - Note 3" appearing elsewhere in this Quarterly Report.
Collaboration and licensing revenues
Collaboration and licensing revenues decreased $14.7 million, or 98%, from the six months ended June 30, 2020 primarily due to the accelerated recognition of previously deferred revenue in the prior period upon the mutual termination of a collaboration with Castle Creek in February 2020.
Product revenues and gross margin
Product revenues increased $1.2$2.3 million, or 9%37%, over the sixthree months ended June 30, 2020.March 31, 2021. The increase in product revenue was primarily due to higher customer demand for animals as a result of stronger beef and dairy industries in the current year. Gross margin on products improved in the current period as a result of the increased revenues and increased focus on selling higher margin products, and operational efficiencies that have been gained through reductions in workforce and improved inventory management.
47

Table of Contents
products.
Service revenues and gross margin
Service revenues increased $11.4$5.3 million, or 36%29%, over the sixthree months ended June 30, 2020.March 31, 2021. Trans Ova's revenues and gross margins thereon improved primarily due to an increase in services performed as a result of higher customer demand as the beef and dairy industries have been stronger in the current year and a change in pricing structure with certain customers. Additionally, Exemplar's service revenues and gross margins thereon improved in the current period due to an increase in services performed resulting from a higher demand from existing and new customers as well as a combination of price increases and a change in the pricing structure with certain customers. Gross margin on services remained comparable to the prior year as increased revenues were offset by increased costs for supplies, drugs, and personnel costs.
39

Table of Contents
Research and development expenses
Research and development expenses increased $3.4$2.2 million, or 16%21%, over the sixthree months ended June 30, 2020.March 31, 2021. Contract research organization costs and lab supplies increased $3.8$1.6 million with the advancement of our clinical and preclinical programs.
Selling, general and administrative expenses
SG&A expenses were comparable periodincreased $0.9 million, or 5%, over periodthe three months ended March 31, 2021. Professional fees increased $1.6 million, primarily due to offsetting changes. Salaries,increased legal fees associated with certain litigation matters. This increase was partially offset with a decrease in salaries, benefits, and other personnel costs decreased $1.6of $1.3 million in 2021 primarily due to a reduced headcount as we scaled down our corporate functions to support our more streamlined organization and reduced stock compensation costs for previously granted awards that became fully vested in early 2021. These decreases were partially offset by an increase in professional fees2022 and reduced head count.
Total other expense, net
Total other expense, net, is comprised primarily of interest expense associated with certainour Convertible Notes issued July 2018. The current litigation matters.period decrease is primarily due to the adoption of a new accounting standard effective January 1, 2022 noted above, which simplified the accounting for the Convertible Notes and reduced non-cash interest expense.

Segment performance
The following table summarizes Segment Adjusted EBITDA, which is our primary measure of segment performance, for the sixthree months ended June 30, 2020March 31, 2022 and 2020,2021, for each of our reportable segments as well as unallocated corporate costs.
Six Months Ended 
 June 30,
Dollar
Change
Percent
Change
Three Months Ended 
 March 31,
Dollar
Change
Percent
Change
20212020 20222021
(In thousands)  (In thousands) 
Segment Adjusted EBITDA:Segment Adjusted EBITDA:Segment Adjusted EBITDA:
BiopharmaceuticalsBiopharmaceuticals$(21,394)$(17,345)$(4,049)(23.3)%Biopharmaceuticals$(11,620)$(8,854)$(2,766)(31.2)%
ExemplarExemplar3,695 857 2,838 >200%Exemplar3,558 1,806 1,752 97.0 %
Trans OvaTrans Ova18,433 7,668 10,765 140.4 %Trans Ova5,397 6,421 (1,024)(15.9)%
Unallocated corporate costsUnallocated corporate costs(18,246)(18,650)404 (2.2)%Unallocated corporate costs(10,060)(8,194)(1,866)22.8 %
For a reconciliation of Segment Adjusted EBITDA to net loss from continuing operations before income taxes, see "Notes to the Condensed Consolidated Financial Statements (Unaudited) - Note 19"18" appearing elsewhere in this Quarterly Report.
The following table summarizes revenues from external customers for the sixthree months ended June 30,March 31, 2022 and 2021, and 2020, for each of our reportable segments.
Six Months Ended 
 June 30,
Dollar
Change
Percent
Change
Three Months Ended 
 March 31,
Dollar
Change
Percent
Change
20212020 20222021
(In thousands)  (In thousands) 
BiopharmaceuticalsBiopharmaceuticals$594 $15,322 $(14,728)(96.1)%Biopharmaceuticals$84 $178 $(94)(52.8)%
ExemplarExemplar6,656 4,256 2,400 56.4 %Exemplar5,429 3,257 2,172 66.7 %
Trans OvaTrans Ova50,841 40,630 10,211 25.1 %Trans Ova26,508 21,076 5,432 25.8 %
Biopharmaceuticals
The decrease in revenues for Biopharmaceuticals was primarily due to the accelerated recognition of previously deferred revenue in the prior period upon the mutual termination of a collaboration with Castle Creek in February 2020. Segment Adjusted EBITDA declined as we had increased costs associated with the advancement of our clinical and preclinical programs.
48

Table of Contents
Exemplar
Revenues for Exemplar increased due to an increase in services performed resulting from a higher demand from existing and new customers. Revenues also increased due to price increases as well as a change in the pricing structure with certain customers. The improvement in Segment Adjusted EBITDA was primarily due to the increased revenues and reduced costs as a resultrevenues.
40

Table of operational efficiencies gained through reductions in workforce and improved inventory management.Contents
Trans Ova
Revenues for Trans Ova increased primarily due to (i) higher customer demand for pregnant cows, and(ii) more procedures performed as a result of stronger beef and dairy industries in the current year. Revenues also increased due toyear, and (iii) a change in the pricing structure with certain customers. The improvement in Segment Adjusted EBITDA was primarilydeclined due to the(i) increased revenues, as well as reduced costs as a result of operational efficiencies gained through reductions in workforcefor supplies and improved inventory management.drugs, (ii) increased costs for certain legal matters, and (iii) increased salaries, benefits, and other personnel costs.
Unallocated Corporate Costs
Unallocated corporate costs were comparable period over period due to offsetting changes. Our unallocated corporate costs decreased from the prior periodincreased primarily due to a reduction of corporate employees as we scaled down our corporate functions to support our more streamlined organization. These decreases were partially offset with increased professional fees including legal fees associated with certain current litigation matters.
Liquidity and capital resources
Sources of liquidity
We have incurred losses from operations since our inception, and as of June 30, 2021,March 31, 2022, we had an accumulated deficit of $1.9 billion. From our inception through June 30, 2021,March 31, 2022, we have funded our operations principally with proceeds received from private and public equity and debt offerings, cash received from our collaborators, and through product and service sales made directly to customers. As of June 30, 2021,March 31, 2022, we had cash and cash equivalents of $36.4$40.3 million and short-term and long-term investments of $164.0$101.7 million. Cash in excess of immediate requirements is typically invested primarily in money market funds and U.S. government debt securities in order to maintain liquidity and preserve capital.
We currently generate cash receipts primarily from sales of products and services and from strategic transactions.
As of June 30, 2021, Trans Ova was in compliance with the debtis subject to certain restrictive covenants associated withunder its line of credit, aswhich matured on April 1, 2022, which is discussed in "Notes to the Condensed Consolidated Financial Statements (Unaudited) - Note 11" appearing elsewhere in this Quarterly Report. As of March 31, 2022, Trans Ova was in compliance with these debt covenants.
Cash flows
The following table sets forth the significant sources and uses of cash for the periods set forth below:
Six Months Ended 
 June 30,
Three Months Ended 
 March 31,
20212020 20222021
(In thousands) (In thousands)
Net cash provided by (used in):Net cash provided by (used in):Net cash provided by (used in):
Operating activitiesOperating activities$(24,160)$(41,548)Operating activities$(18,783)$(16,384)
Investing activitiesInvesting activities(112,482)(12,586)Investing activities16,568 (129,102)
Financing activitiesFinancing activities121,063 32,891 Financing activities(163)121,040 
Effect of exchange rate changes on cash, cash equivalents, and restricted cashEffect of exchange rate changes on cash, cash equivalents, and restricted cash184 (59)Effect of exchange rate changes on cash, cash equivalents, and restricted cash(230)(11)
Net decrease in cash, cash equivalents, and restricted cashNet decrease in cash, cash equivalents, and restricted cash$(15,395)$(21,302)Net decrease in cash, cash equivalents, and restricted cash$(2,608)$(24,457)
Cash flows from operating activities:
During the sixthree months ended June 30, 2021,March 31, 2022, our net loss was $37.4$19.3 million, which includes the following significant noncash expenses totaling $21.6$7.5 million from continuing operations: (i) $3.6 million of stock-based compensation expense, (ii) $3.3 million of depreciation and amortization expense, and (iii) $0.6 million of shares issued as payment for services.
During the three months ended March 31, 2021, our net loss was $17.3 million, which includes the following significant noncash expenses totaling $12.3 million from both continuing and discontinued operations: (i) $9.0$5.4 million of stock-based compensation
49

Table of Contents
expense, (ii) $7.0$3.5 million of depreciation and amortization expense, and (iii) $5.6$2.8 million accretion of debt discount and amortization of deferred financing costs.costs, and (iv) $0.6 million of shares issued as payment for services. These expenses were partially offset by a $4.6 million noncash gain recognized upon the termination of our MBP Titan facility lease in January 2021.
During the six months ended June 30, 2020, our net loss was $99.4 million, which includes the following significant noncash expenses totaling $73.0 million from both continuing and discontinued operations: (i) $27.0 million
41

Table of accumulated foreign currency translation losses that were realized upon the closing of the Transactions, (ii) $22.0 million of impairment losses related to goodwill and long-lived assets, (iii) $9.6 million of depreciation and amortization expense, (iv) $9.3 million of stock-based compensation expense, and (v) $5.1 million accretion of debt discount and amortization of deferred financing costs. These expenses were partially offset by the recognition of $10.0 million of previously deferred revenue upon the mutual termination of a collaboration with Castle Creek in February 2020.Contents
Our cash outflows from operations during the sixthree months ended June 30, 2021 decreased $17.4March 31, 2022 increased $2.4 million from the sixthree months ended June 30, 2020March 31, 2021 primarily due to (i) increased cash inflows provided by Trans Ova and Exemplar due to increased revenues and gross margins thereon, (ii)costs associated with the reduction in cash requirements for MBP Titan as we suspended those operations in the second quarter of 2020, and (iii) reductions in operating expenses for our corporate operations as we streamlined operations in order to further prioritize the useadvancement of our capital.clinical and preclinical programs.
Cash flows from investing activities:
During the sixthree months ended June 30,March 31, 2022, we received $18.0 million of proceeds from maturities of investments.
During the three months ended March 31, 2021, we purchased $116.2$133.7 million of investments, net of maturities, and sales, primarily using the proceeds received from the underwritten public offering discussed below.
During the six months ended June 30, 2020, we purchased $76.3 million of investments, net of maturities, primarily using the $64.2 million of proceeds received from the Transactions, net of cash sold, and the private placement discussed below.
Cash flows from financing activities:
During the sixthree months ended June 30,March 31, 2022, we made payments of long-term debt of $0.2 million.
During the three months ended March 31, 2021, we received $121.0 million net proceeds from the sale of our common stock in an underwritten public offering.
During the six months ended June 30, 2020, we received $35.0 million proceeds from the sale of our common stock in a private placement to TS Biotechnology Holdings, LLC.
Future capital requirements
We believe our existing liquid assets will enable us to fund our operating expenses and capital requirements for at least the next 12 months. Our future capital requirements will depend on many factors, including:
progress in our research and development programs, as well as the magnitude of these programs;
any delays or potential delays to our clinical trials as a result of the COVID-19 pandemic;
the timing of regulatory approval of our product candidates and those of our collaborations;
the timing, receipt, and amount of any payments received in connection with strategic transactions;
the timing, receipt, and amount of upfront, milestone, and other payments, if any, from present and future collaborators, if any;
the timing, receipt, and amount of sales and royalties, if any, from our product candidates;
the timing and capital requirements to scale up our various product candidates and service offerings and customer acceptance thereof;
our ability to maintain and establish additional collaborative arrangements and/or new strategic initiatives;
50

Table of Contents
the resources, time, and cost required for the preparation, filing, prosecution, maintenance, and enforcement of our intellectual property portfolio;
strategic mergers and acquisitions, if any, including both the upfront acquisition cost as well as the cost to integrate, maintain, and expand the strategic target;
the costs associated with legal activities, including litigation, arising in the course of our business activities and our ability to prevail in any such legal disputes; and
the effects, duration, and severity of the ongoing COVID-19 pandemic and the actions we have taken or may take in response, any of which could significantly impact our business, operations, and financial results.
Until such time, if ever, as we can regularly generate positive operating cash flows, we plan to finance our cash needs through a combination of equity offerings, debt financings, government, or other third-party funding, strategic alliances, sales of assets, and licensing arrangements. As the COVID-19 pandemic continues to negatively impact the economy, our future access to capital on favorable terms may be materially impacted. We may not be able to raise sufficient additional funds on terms that are favorable to us, if at all. To the extent that we raise additional capital through the sale of equity or convertible debt securities,
42

Table of Contents
the ownership interests of our common shareholders will be diluted, and the terms of these securities may include liquidation or other preferences that adversely affect the rights of our common shareholders. Our current stock price may make it more difficult to pursue equity financings and lead to substantial dilution if the price of our common stock does not increase. Debt financing, if available, may involve agreements that include covenants limiting or restricting our ability to take specific actions, such as incurring additional debt, making capital expenditures, or declaring dividends. If we raise additional funds through strategic transactions, collaborations, or licensing arrangements with third parties, we may have to relinquish valuable rights to our technologies, future revenue streams, research programs, or product candidates, or to grant licenses on terms that may not be favorable to us.
We are subject to a number of risks similar to those of other companies conducting high-risk, early-stage research and development of product candidates. Principal among these risks are dependence on key individuals and intellectual property, competition from other products and companies, and the technical risks associated with the successful research, development, and clinical manufacturing of its product candidates. Our success is dependent upon our ability to continue to raise additional capital in order to fund ongoing research and development, adequately satisfy or renegotiate long-term debt obligations, obtain regulatory approval of our products, successfully commercialize our products, generate revenue, meet our obligations, and, ultimately, attain profitable operations. Our ability to achieve what is necessary for our success may be negatively impacted by the uncertainty caused by the COVID-19 pandemic.
See the section entitled "Risk Factors" in our Annual Report for additional risks associated with our substantial capital requirements.
Contractual obligations and commitments
The following table summarizes our significant contractual obligations and commitments from continuing operations as of June 30, 2021March 31, 2022 and the effects such obligations are expected to have on our liquidity and cash flows in future periods:
TotalLess Than 1 Year1 - 3 Years3 - 5 YearsMore Than 5 YearsTotalLess Than 1 Year1 - 3 Years3 - 5 YearsMore Than 5 Years
(In thousands) (In thousands)
Operating leasesOperating leases$19,790 $3,344 $6,192 $4,945 $5,309 Operating leases$15,838 $2,718 $5,035 $3,788 $4,297 
Convertible debt (1)Convertible debt (1)200,000 — 200,000 — — Convertible debt (1)200,000 — 200,000 — — 
Cash interest payable on convertible debtCash interest payable on convertible debt17,500 7,000 10,500 — — Cash interest payable on convertible debt10,500 7,000 3,500 — — 
Long-term debt, excluding convertible debtLong-term debt, excluding convertible debt3,501 356 772 783 1,590 Long-term debt, excluding convertible debt3,105 355 752 814 1,184 
TotalTotal$240,791 $10,700 $217,464 $5,728 $6,899 Total$229,443 $10,073 $209,287 $4,602 $5,481 
(1)See "Notes to the Condensed Consolidated Financial Statements (Unaudited) - Notes 11" appearing elsewhere in this Quarterly Report for further discussion of our convertible debt.
51

Table of Contents
In addition to the obligations in the table above, as of June 30, 2021March 31, 2022 we also have the following significant contractual obligations described below.
In conjunction with the formation of our JVs, we committed to making future capital contributions subject to certain conditions and limitations. As of June 30, 2021,March 31, 2022, our remaining capital contribution commitments to our JVs were $14.2 million. These future capital contributions are not included in the table above due to the uncertainty of the timing and amounts of such contributions.
We are party to in-licensed research and development agreements with various academic and commercial institutions where we could be required to make future payments for annual maintenance fees as well as for milestones and royalties we might receive upon commercial sales of products that incorporate their technologies. These agreements are generally subject to termination by us and therefore no amounts are included in the tables above. As of June 30, 2021,March 31, 2022, we also had research and development commitments with third parties totaling $17.0$22.7 million that had not yet been incurred.
43

Table of Contents
Net operating losses
As of June 30, 2021,March 31, 2022, we had net operating loss carryforwards of approximately $813.7$861.0 million for U.S. federal income tax purposes available to offset future taxable income, including $561.0$609.0 million generated after 2017, U.S. capital loss carryforwards of $211.5$212.5 million, and U.S. federal and state research and development tax credits of approximately $10.5$11.3 million, prior to consideration of annual limitations that may be imposed under Section 382 of the Internal Revenue Code of 1986, as amended, or Section 382. Net operating loss carryforwards generated prior to 2018 beginhave begun to expire in 2022, and capital loss carryforwards will expire if unutilized beginning in 2024. Our foreign subsidiaries included in continuing operations have foreign loss carryforwards of approximately $79.1$74.2 million, most of which do not expire. Excluding certain deferred tax liabilities totaling $2.7$2.4 million, our remaining net deferred tax assets, which primarily relate to these loss carryforwards, are offset by a valuation allowance due to our history of net losses.
As a result of our past issuances of stock, as well as due to prior mergers and acquisitions, certain of our net operating losses have been subject to limitations pursuant to Section 382. As of June 30, 2021,March 31, 2022, Precigen has utilized all net operating losses subject to Section 382 limitations, other than those losses inherited via acquisitions. As of June 30, 2021,March 31, 2022, approximately $42.1 million of available domestic net operating losses were inherited via acquisitions and are limited based on the value of the target at the time of the transaction. Future changes in stock ownership may also trigger an ownership change and, consequently, a Section 382 limitation.
Off-balance sheet arrangements
We did not have during the periods presented, and we do not currently have, any off-balance sheet arrangements as defined under Securities and Exchange Commission, or SEC rules.
Critical accounting policies and estimates
Our management's discussion and analysis of our financial condition and results of operations is based on our condensed consolidated financial statements, which we have prepared in accordance with generally accepted accounting principles in the United States. The preparation of these condensed consolidated financial statements requires us to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the financial statements, as well as the reported revenues and expenses during the reporting periods. We evaluate these estimates and judgments on an ongoing basis. We base our estimates on historical experience and on various other factors that we believe are reasonable under the circumstances, the results of which form the basis for making judgments about the carrying value of assets and liabilities that are not readily apparent from other sources. Our actual results may differ from these estimates under different assumptions or conditions.
There have been no material changes to our critical accounting policies from those described in "Management's Discussion and Analysis of Financial Condition and Results of Operations" included in our Annual Report.
Recent accounting pronouncements
For information with respect to recent accounting pronouncements and the impact of these pronouncements on our condensed consolidated financial statements, see "Notes to the Condensed Consolidated Financial Statements (Unaudited) - Note 2" appearing elsewhere in this Quarterly Report.
52


Item 3. Quantitative and Qualitative Disclosures About Market Risk
The following sections provide quantitative information on our exposure to interest rate risk. We make use of sensitivity analyses that are inherently limited in estimating actual losses in fair value that can occur from changes in market conditions.
Interest rate risk
We had cash, cash equivalents and short-term and long-term investments of $200.4$142.1 million and $100.1$163.7 million as of June 30, 2021March 31, 2022 and December 31, 2020,2021, respectively. Our cash and cash equivalents and short-term and long-term investments consist of cash, money market funds, U.S. government debt securities, and certificates of deposit. The primary objectives of our investment activities are to preserve principal, maintain liquidity, and maximize income without significantly increasing risk. Our investments consist of U.S. government debt securities and certificates of deposit, which may be subject to market risk due to changes in prevailing interest rates that may cause the fair values of our investments to fluctuate. We believe that a
44


hypothetical 100 basis point increase in interest rates would not materially affect the fair value of our interest-sensitive financial instruments and any such losses would only be realized if we sold the investments prior to maturity.
Item 4. Controls and Procedures
Pursuant to Rule 13a-15(b) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), we carried out an evaluation, under supervision and with the participation of our management, including our Chief Executive Officer ("CEO"), who is our principal executive officer, and our Executive Director, FinanceChief Financial Officer ("EDF"CFO"), who is our interim principal financial officer, of the effectiveness of the design and operation of our disclosure controls and procedures (as defined under Rule 13a-15(e) and 15d-15(e) under the Exchange Act) as of the end of the period covered by this report. Based upon that evaluation, as of the end of the period covered by this report, our CEO and EDFCFO concluded that our disclosure controls and procedures are effective at the reasonable assurance level to ensure that information required to be disclosed by us in the reports that we file or submit under the Exchange Act, is recorded, processed, summarized and reported, within the time periods specified in the SEC's rules and forms, and that such information is accumulated and communicated to our management, including our CEO and EDF,CFO, as appropriate, to allow timely decisions regarding required disclosure.
There has been no change in our internal control over financial reporting during the three months ended June 30, 2021,March 31, 2022, that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.
5345

Table of Contents
PART II. OTHER INFORMATION 
Item 1. Legal Proceedings
In the course of our business, we are involved in litigation or legal matters, including governmental investigations. Such matters are subject to many uncertainties and outcomes are not predictable with assurance. We accrue liabilities for such matters when it is probable that future expenditures will be made and such expenditures can be reasonably estimated. As of June 30, 2021,March 31, 2022, we do not believe that any such matters, individually or in the aggregate, will have a material adverse effect on our business, financial condition, results of operations, or cash flows.
See "Notes to the Condensed Consolidated Financial Statements (Unaudited) - Note 16" appearing elsewhere in this Quarterly Report for further discussion of ongoing legal matters.
Item 1A. Risk Factors
As disclosed in "Summary of Risk Factors" and "Item 1A. Risk Factors" in our Annual Report, there are a number of risks and uncertainties that may have a material effect on the operating results of our business and our financial condition. There are no additional material updates or changes to our risk factors since the filing of our Annual Report.
In evaluating our risks, readers also should carefully consider the risk factors discussed in our Annual Report, which could materially affect our business, financial condition, or operating results, in addition to the other information set forth in this report and in our other filings with the SEC.
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds
None.
Item 3. Defaults on Senior Securities
None.
Item 4. Mine Safety Disclosures
Not applicable.
Item 5. Other Information
None.
5446


Item 6. Exhibits
Exhibit
No.
 Description
31.1 
31.2 
32.1** 
32.2** 
101** 
Interactive Data File (Quarterly Report on Form 10-Q, for the quarterly period ended June 30, 2021,March 31, 2022, formatted in Inline XBRL (eXtensible Business Reporting Language)).
 
Attached as Exhibit 101.0 to this Quarterly Report on Form 10-Q are the following documents formatted in XBRL: (i) the Condensed Consolidated Balance Sheets as of June 30, 2021March 31, 2022 and December 31, 2020,2021, (ii) the Condensed Consolidated Statements of Operations for the three and six months ended June 30,March 31, 2022 and 2021, and 2020, (iii) the Condensed Consolidated Statements of Comprehensive Loss for the three and six months ended June 30,March 31, 2022 and 2021, and 2020, (iv) the Condensed Consolidated Statements of Shareholders' Equity for the three and six months ended June 30,March 31, 2022 and 2021, and 2020, (v) the Condensed Consolidated Statements of Cash Flows for the sixthree months ended June 30,March 31, 2022 and 2021, and 2020, and (vi) the Notes to the Condensed Consolidated Financial Statements.
104** Cover Page Interactive Data File (embedded within the Inline XBRL document).
**    Furnished herewith.
5547


SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
 
 Precigen, Inc.
 (Registrant)
Date: AugustMay 9, 20212022 By: /s/  JAMES V. LAMBERTHARRY THOMASIAN JR.
  James V. LambertHarry Thomasian Jr.
  Executive Director, FinanceChief Financial Officer
  (Interim Principal Financial and Accounting Officer)

5648