UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q


(Mark One)
☒			QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the Quarterly Period Ended June 30, ~~2022~~2023


☐			TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from to

Commission File Number: 001-35060

PACIRA BIOSCIENCES, INC.

(Exact Name of Registrant as Specified in its Charter)


Delaware						51-0619477
(State or Other Jurisdiction of Incorporation or Organization)						(I.R.S. Employer Identification No.)

5401 West Kennedy Boulevard, Suite 890

Tampa, Florida 33609

(Address and Zip Code of Principal Executive Offices)

(813) 553-6680

(Registrant’s Telephone Number, Including Area Code)

Securities registered pursuant to Section 12(b) of the Act:

Title of each class

Trading symbol

Name of each exchange on which registered

Common Stock, par value $0.001 per share

PCRX

Nasdaq Global Select Market

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. ☒ Yes ☐ No

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files.) ☒ Yes ☐ No

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer”, “accelerated filer”, “smaller reporting company”, and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer

☒

Accelerated filer

☐

Non-accelerated filer

☐

Smaller reporting company

☐

Emerging growth company

☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). ☐ Yes ☒ No

As of August 1, ~~2022, 45,824,210~~2023, 46,417,025 shares of the registrant’s common stock, $0.001 par value per share, were outstanding.

Table of Contents

PACIRA BIOSCIENCES, INC.

QUARTERLY REPORT ON FORM 10-Q

FOR THE QUARTER ENDED JUNE 30, ~~2022~~2023

TABLE OF CONTENTS


		Page #
PART I. FINANCIAL INFORMATION		4

Item 1.	Financial Statements (Unaudited)	4
	Condensed Consolidated Balance Sheets	4
	Condensed Consolidated Statements of Operations	5
	Condensed Consolidated Statements of Comprehensive Income	6
	Condensed Consolidated Statements of Stockholders’ Equity	7
	Condensed Consolidated Statements of Cash Flows	9
	Notes to Condensed Consolidated Financial Statements	10
Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	3230
Item 3.	Quantitative and Qualitative Disclosures About Market Risk	4845
Item 4.	Controls and Procedures	4945

PART II. OTHER INFORMATION		47

Item 1.	Legal Proceedings	5047
Item 1A.	Risk Factors	5047
Item 2.	Unregistered Sales of Equity Securities and Use of Proceeds	5047
Item 3.	Defaults Upon Senior Securities	5047
Item 4.	Mine Safety Disclosures	5047
Item 5.	Other Information	5047
Item 6.	Exhibits	5147
Signatures		5249

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 3

Table of Contents

PART I — FINANCIAL INFORMATION

Item 1. FINANCIAL STATEMENTS (Unaudited)

PACIRA BIOSCIENCES, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS

(In thousands, except share and per share amounts)

(Unaudited)


		June 30, 2022		December 31, 2021			June 30, 2023		December 31, 2022
ASSETS	ASSETS					ASSETS
Current assets:	Current assets:					Current assets:
Cash and cash equivalents	Cash and cash equivalents	$	122,061	$	585,578	Cash and cash equivalents	$	86,810	$	104,139
Short-term available-for-sale investments	Short-term available-for-sale investments	194,332		70,831		Short-term available-for-sale investments	133,956		184,512
Accounts receivable, net	Accounts receivable, net	91,105		96,318		Accounts receivable, net	99,079		98,397
Inventories, net	Inventories, net	100,588		98,550		Inventories, net	92,130		96,063
Prepaid expenses and other current assets	Prepaid expenses and other current assets	18,124		14,771		Prepaid expenses and other current assets	17,349		15,223
Total current assets	Total current assets	526,210		866,048		Total current assets	429,324		498,334

Noncurrent available-for-sale investments						Noncurrent available-for-sale investments	—		37,209
Fixed assets, net	Fixed assets, net	191,279		188,401		Fixed assets, net	180,310		183,512
Right-of-use assets, net	Right-of-use assets, net	72,082		76,410		Right-of-use assets, net	65,837		70,877
Goodwill	Goodwill	146,132		145,175		Goodwill	163,243		163,243
Intangible assets, net	Intangible assets, net	595,324		623,968		Intangible assets, net	511,902		540,546
Deferred tax assets	Deferred tax assets	167,149		153,364		Deferred tax assets	156,140		160,309
Investments and other assets	Investments and other assets	35,812		21,987		Investments and other assets	35,625		27,170
Total assets	Total assets	$	1,733,988	$	2,075,353	Total assets	$	1,542,381	$	1,681,200

LIABILITIES AND STOCKHOLDERS’ EQUITY	LIABILITIES AND STOCKHOLDERS’ EQUITY					LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:	Current liabilities:					Current liabilities:
Accounts payable	Accounts payable	$	13,983	$	10,543	Accounts payable	$	24,206	$	15,220
Accrued expenses	Accrued expenses	77,275		127,555		Accrued expenses	56,221		89,785
Lease liabilities	Lease liabilities	8,134		7,891		Lease liabilities	8,981		9,121
Convertible senior notes, net		—		350,466
Current portion of convertible senior notes, net						Current portion of convertible senior notes, net	8,641		—

Current portion of long-term debt, net	Current portion of long-term debt, net	33,776		24,234		Current portion of long-term debt, net	10,863		33,648
Income taxes payable		11		429

Total current liabilities	Total current liabilities	133,179		521,118		Total current liabilities	108,912		147,774
Convertible senior notes, net	Convertible senior notes, net	403,534		339,267		Convertible senior notes, net	397,360		404,767
Long-term debt, net	Long-term debt, net	318,344		335,263		Long-term debt, net	134,823		251,056
Lease liabilities	Lease liabilities	67,575		71,727		Lease liabilities	60,046		64,802

Contingent consideration	Contingent consideration	35,247		57,598		Contingent consideration	21,482		28,122
Other liabilities	Other liabilities	19,473		19,972		Other liabilities	11,783		9,669
Total liabilities	Total liabilities	977,352		1,344,945		Total liabilities	734,406		906,190
Commitments and contingencies (Note 16)		0		0
Commitments and contingencies (Note 15)						Commitments and contingencies (Note 15)
Stockholders’ equity:	Stockholders’ equity:					Stockholders’ equity:
Preferred stock, par value $0.001; 5,000,000 shares authorized; none issued and outstanding at June 30, 2022 and December 31, 2021		—		—
Common stock, par value $0.001; 250,000,000 shares authorized; 45,801,578 and 44,734,308 shares issued and outstanding at June 30, 2022 and December 31, 2021, respectively		46		45
Preferred stock, par value $0.001; 5,000,000 shares authorized; none issued and outstanding at June 30, 2023 and December 31, 2022						Preferred stock, par value $0.001; 5,000,000 shares authorized; none issued and outstanding at June 30, 2023 and December 31, 2022	—		—
Common stock, par value $0.001; 250,000,000 shares authorized; 46,408,961 and 45,927,790 shares issued and outstanding at June 30, 2023 and December 31, 2022, respectively						Common stock, par value $0.001; 250,000,000 shares authorized; 46,408,961 and 45,927,790 shares issued and outstanding at June 30, 2023 and December 31, 2022, respectively	46		46
Additional paid-in capital	Additional paid-in capital	895,151		942,091		Additional paid-in capital	950,626		924,095
Accumulated deficit	Accumulated deficit	(137,956)		(211,895)		Accumulated deficit	(142,524)		(148,751)
Accumulated other comprehensive (loss) income		(605)		167
Accumulated other comprehensive loss						Accumulated other comprehensive loss	(173)		(380)
Total stockholders’ equity	Total stockholders’ equity	756,636		730,408		Total stockholders’ equity	807,975		775,010
Total liabilities and stockholders’ equity	Total liabilities and stockholders’ equity	$	1,733,988	$	2,075,353	Total liabilities and stockholders’ equity	$	1,542,381	$	1,681,200

See accompanying notes to condensed consolidated financial statements.

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 4

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PACIRA BIOSCIENCES, INC.

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(In thousands, except per share amounts)

(Unaudited)


		Three Months Ended June 30,				Six Months Ended June 30,					Three Months Ended June 30,				Six Months Ended June 30,
		2022		2021		2022		2021			2023		2022		2023		2022
Revenues:	Revenues:									Revenues:
Net product sales	Net product sales	$	168,581	$	134,863	$	326,003	$	253,601	Net product sales	$	169,467	$	168,581	$	328,898	$	326,003
Royalty revenue	Royalty revenue	830		602		1,399		891		Royalty revenue	—		830		910		1,399
Collaborative licensing and milestone revenue		—		125		—		125

Total revenues	Total revenues	169,411		135,590		327,402		254,617		Total revenues	169,467		169,411		329,808		327,402
Operating expenses:	Operating expenses:									Operating expenses:
Cost of goods sold	Cost of goods sold	50,627		35,248		86,701		66,597		Cost of goods sold	48,207		50,627		97,227		86,701
Research and development	Research and development	26,282		12,573		47,887		28,453		Research and development	18,824		26,282		35,964		47,887
Selling, general and administrative	Selling, general and administrative	65,003		50,813		129,263		99,335		Selling, general and administrative	64,850		65,003		135,693		129,263
Amortization of acquired intangible assets	Amortization of acquired intangible assets	14,322		1,967		28,644		3,933		Amortization of acquired intangible assets	14,322		14,322		28,644		28,644
Acquisition-related (gains) charges, product discontinuation and other		(18,058)		146		(13,721)		2,019
Acquisition-related (gains) charges, restructuring charges and other										Acquisition-related (gains) charges, restructuring charges and other	(16,613)		(18,058)		(4,506)		(13,721)
Total operating expenses	Total operating expenses	138,176		100,747		278,774		200,337		Total operating expenses	129,590		138,176		293,022		278,774
Income from operations	Income from operations	31,235		34,843		48,628		54,280		Income from operations	39,877		31,235		36,786		48,628
Other (expense) income:	Other (expense) income:									Other (expense) income:
Interest income	Interest income	252		224		523		639		Interest income	2,111		252		5,253		523
Interest expense	Interest expense	(8,833)		(7,023)		(19,079)		(13,994)		Interest expense	(3,865)		(8,833)		(13,454)		(19,079)

Loss on early extinguishment of debt										Loss on early extinguishment of debt	—		—		(16,926)		—
Other, net	Other, net	(647)		(2,396)		(771)		(2,554)		Other, net	(269)		(647)		(279)		(771)
Total other expense, net	Total other expense, net	(9,228)		(9,195)		(19,327)		(15,909)		Total other expense, net	(2,023)		(9,228)		(25,406)		(19,327)
Income before income taxes	Income before income taxes	22,007		25,648		29,301		38,371		Income before income taxes	37,854		22,007		11,380		29,301
Income tax expense	Income tax expense	(2,131)		(6,567)		(2,597)		(8,921)		Income tax expense	(12,091)		(2,131)		(5,153)		(2,597)
Net income	Net income	$	19,876	$	19,081	$	26,704	$	29,450	Net income	$	25,763	$	19,876	$	6,227	$	26,704

Net income per share:	Net income per share:									Net income per share:
Basic net income per common share	Basic net income per common share	$	0.44	$	0.43	$	0.59	$	0.67	Basic net income per common share	$	0.56	$	0.44	$	0.14	$	0.59
Diluted net income per common share	Diluted net income per common share	$	0.40	$	0.42	$	0.55	$	0.64	Diluted net income per common share	$	0.51	$	0.40	$	0.13	$	0.55
Weighted average common shares outstanding:	Weighted average common shares outstanding:									Weighted average common shares outstanding:
Basic	Basic	45,501		44,145		45,185		43,989		Basic	46,088		45,501		46,019		45,185
Diluted	Diluted	52,478		45,592		52,262		45,779		Diluted	52,054		52,478		46,285		52,262

See accompanying notes to condensed consolidated financial statements.

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 5

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PACIRA BIOSCIENCES, INC.

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME

(In thousands)

(Unaudited)


		Three Months Ended June 30,				Six Months Ended June 30,					Three Months Ended June 30,				Six Months Ended June 30,
		2022		2021		2022		2021			2023		2022		2023		2022
Net income	Net income	$	19,876	$	19,081	$	26,704	$	29,450	Net income	$	25,763	$	19,876	$	6,227	$	26,704
Other comprehensive (loss) income:
Other comprehensive income (loss):										Other comprehensive income (loss):
Net unrealized (loss) gain on investments, net of tax	Net unrealized (loss) gain on investments, net of tax	(160)		12		(893)		(138)		Net unrealized (loss) gain on investments, net of tax	(35)		(160)		216		(893)
Foreign currency translation adjustments	Foreign currency translation adjustments	82		(3)		121		1		Foreign currency translation adjustments	(1)		82		(9)		121
Total other comprehensive (loss) income	Total other comprehensive (loss) income	(78)		9		(772)		(137)		Total other comprehensive (loss) income	(36)		(78)		207		(772)
Comprehensive income	Comprehensive income	$	19,798	$	19,090	$	25,932	$	29,313	Comprehensive income	$	25,727	$	19,798	$	6,434	$	25,932

See accompanying notes to condensed consolidated financial statements.

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 6

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PACIRA BIOSCIENCES, INC.

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY

FOR THE THREE MONTHS ENDED JUNE 30, ~~2022~~2023 AND ~~2021~~

2022

(In thousands)

(Unaudited)

Common Stock Additional
Paid-In
Capital Accumulated
Deficit Accumulated Other Comprehensive (Loss) Income
Shares Amount Total
Balance at March 31, 2022 45,064 $ 45 $ 867,890 $ (157,832) $ (527) $ 709,576
Exercise of stock options 307 1 10,856 — — 10,857
Vested restricted stock units 292 — — — — —
Common stock issued under employee stock
purchase plan 37 — 1,821 — — 1,821
Stock-based compensation — — 11,544 — — 11,544
Issuance of common stock upon conversion of 2022 convertible senior notes (Note 9) 102 — 3,040 — — 3,040
Other comprehensive loss (Note 11) — — — — (78) (78)
Net income — — — 19,876 — 19,876
Balance at June 30, 2022 45,802 $ 46 $ 895,151 $ (137,956) $ (605) $ 756,636



	Common Stock			Additional Paid-In Capital		Accumulated Deficit		Accumulated Other Comprehensive Loss
	Shares	Amount								Total
Balance at March 31, 2023	45,970	$	46	$	936,419	$	(168,287)	$	(137)	$	768,041

Exercise of stock options	50	—		1,580		—		—		1,580
Vested restricted stock units	339	—		—		—		—		—
Common stock issued under employee stock purchase plan	50	—		1,672		—		—		1,672
Stock-based compensation	—	—		10,955		—		—		10,955


Other comprehensive loss (Note 10)	—	—		—		—		(36)		(36)
Net income	—	—		—		25,763		—		25,763
Balance at June 30, 2023	46,409	$	46	$	950,626	$	(142,524)	$	(173)	$	807,975


		Common Stock			Additional Paid-In Capital				Accumulated Deficit			Accumulated Other Comprehensive (Loss) Income
		Shares	Amount								Total			Common Stock							Additional Paid-In Capital			Accumulated Deficit		Accumulated Other Comprehensive Loss
Balance at March 31, 2021		43,958	$	44			$	894,108				$	(243,506)		$	172			$	650,818
																		Shares					Amount					Additional Paid-In Capital			Accumulated Deficit			Accumulated Other Comprehensive Loss	Total
Balance at March 31, 2022																	Balance at March 31, 2022	45,064			$	45							$	709,576

Exercise of stock options	Exercise of stock options	162	—		5,225				—			—			5,225		Exercise of stock options	307			1			10,856		—			—			10,857
Vested restricted stock units	Vested restricted stock units	286	—		—				—			—			—		Vested restricted stock units	292			—			—		—			—			—
Common stock issued under employee stock purchase plan	Common stock issued under employee stock purchase plan	31	—		1,574				—			—			1,574		Common stock issued under employee stock purchase plan	37			—			1,821		—			—			1,821
Stock-based compensation	Stock-based compensation	—	—		10,461				—			—			10,461		Stock-based compensation	—			—			11,544		—			—			11,544
Issuance of common stock upon conversion of 2022 convertible senior notes																	Issuance of common stock upon conversion of 2022 convertible senior notes	102			—			3,040		—			—			3,040

Other comprehensive income (Note 11)		—	—		—				—			9			9
Other comprehensive loss (Note 10)																	Other comprehensive loss (Note 10)	—			—			—		—			(78)			(78)
Net income	Net income	—	—		—				19,081			—			19,081		Net income	—			—			—		19,876			—			19,876
Balance at June 30, 2021		44,437	$	44	$	911,368			$	(224,425)		$	181		$	687,168
Balance at June 30, 2022																	Balance at June 30, 2022	45,802			$	46		$	895,151	$	(137,956)		$	(605)		$	756,636

See accompanying notes to condensed consolidated financial statements.

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 7

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PACIRA BIOSCIENCES, INC.

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY

FOR THE SIX MONTHS ENDED JUNE 30, ~~2022~~2023 AND ~~2021~~2022

(In thousands)

(Unaudited)


		Common Stock			Additional Paid-In Capital				Accumulated Deficit			Accumulated Other Comprehensive (Loss) Income						Common Stock					Additional Paid-In Capital				Accumulated Deficit				Accumulated Other Comprehensive Loss
		Shares	Amount								Total			Shares				Amount							Total
Balance at December 31, 2021		44,734	$	45			$	942,091				$	(211,895)		$	167			$	730,408
Reclassification of the equity component of convertible senior notes to liabilities upon adoption of Accounting Standards Update 2020-06 (Note 2)		—	—		(96,468)				47,235			—			(49,233)
Balance at December 31, 2022																	Balance at December 31, 2022	45,928			$	46			$	924,095			$	(148,751)			$	(380)			$	775,010

Exercise of stock options	Exercise of stock options	630	1		21,934				—			—			21,935		Exercise of stock options	62			—		1,914				—				—				1,914
Vested restricted stock units	Vested restricted stock units	299	—		—				—			—			—		Vested restricted stock units	369			—		—				—				—				—
Common stock issued under employee stock purchase plan	Common stock issued under employee stock purchase plan	37	—		1,821				—			—			1,821		Common stock issued under employee stock purchase plan	50			—		1,672				—				—				1,672
Stock-based compensation	Stock-based compensation	—	—		22,733				—			—			22,733		Stock-based compensation	—			—		22,945				—				—				22,945
Issuance of common stock upon conversion of 2022 convertible senior notes (Note 9)		102	—		3,040				—			—			3,040

Other comprehensive loss (Note 11)		—	—		—				—			(772)			(772)
Other comprehensive income (Note 10)																	Other comprehensive income (Note 10)	—			—		—				—				207				207
Net income	Net income	—	—		—				26,704			—			26,704		Net income	—			—		—				6,227				—				6,227
Balance at June 30, 2022		45,802	$	46	$	895,151			$	(137,956)		$	(605)		$	756,636
Balance at June 30, 2023																	Balance at June 30, 2023	46,409			$	46	$	950,626			$	(142,524)			$	(173)			$	807,975


	Common Stock			Additional Paid-In Capital		Accumulated Deficit		Accumulated Other Comprehensive (Loss) Income
	Shares	Amount								Total
Balance at December 31, 2021	44,734	$	45	$	942,091	$	(211,895)	$	167	$	730,408


Reclassification of the equity component of convertible senior notes to liabilities upon adoption of Accounting Standards Update 2020-06 (1)	—	—		(96,468)		47,235		—		(49,233)
Exercise of stock options	630	1		21,934		—		—		21,935
Vested restricted stock units	299	—		—		—		—		—
Common stock issued under employee stock purchase plan	37	—		1,821		—		—		1,821
Stock-based compensation	—	—		22,733		—		—		22,733
Issuance of common stock upon conversion of 2022 convertible senior notes	102	—		3,040		—		—		3,040

Other comprehensive loss (Note 10)	—	—		—		—		(772)		(772)
Net income	—	—		—		26,704		—		26,704
Balance at June 30, 2022	45,802	$	46	$	895,151	$	(137,956)	$	(605)	$	756,636

Common Stock Additional
Paid-In
Capital Accumulated
Deficit Accumulated Other Comprehensive (Loss) Income
Shares Amount Total
Balance at December 31, 2020 43,637 $ 44 $ 873,201 $ (253,875) $ 318 $ 619,688
Exercise of stock options 479 — 16,022 — — 16,022
Vested restricted stock units 290 — — — — —
Common stock issued under employee stock
purchase plan 31 — 1,574 — — 1,574
Stock-based compensation — — 20,571 — — 20,571
Other comprehensive loss (Note 11) — — — — (137) (137)
Net income — — — 29,450 — 29,450
Balance at June 30, 2021 44,437 $ 44 $ 911,368 $ (224,425) $ 181 $ 687,168
(1) Effective January 1, 2022, the Company adopted Accounting Standards Update 2020-06, Debt—Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging—Contracts in Entity’s Own Equity (Subtopic 815-40) on a modified retrospective method of transition. As a result, the Company no longer separately presents in equity an embedded conversion feature for its convertible debt.

See accompanying notes to condensed consolidated financial statements.

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 8

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PACIRA BIOSCIENCES, INC.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(In thousands)

(Unaudited)


		Six Months Ended June 30,					Six Months Ended June 30,
		2022		2021			2023		2022
Operating activities:	Operating activities:					Operating activities:
Net income	Net income	$	26,704	$	29,450	Net income	$	6,227	$	26,704
Adjustments to reconcile net income to net cash provided by operating activities:	Adjustments to reconcile net income to net cash provided by operating activities:					Adjustments to reconcile net income to net cash provided by operating activities:
Deferred taxes	Deferred taxes	2,193		7,613		Deferred taxes	4,100		2,193
Depreciation of fixed assets and amortization of intangible assets	Depreciation of fixed assets and amortization of intangible assets	40,897		9,748		Depreciation of fixed assets and amortization of intangible assets	38,656		40,897
Amortization of debt issuance costs	Amortization of debt issuance costs	2,053		1,310		Amortization of debt issuance costs	1,628		2,053
Amortization of debt discount	Amortization of debt discount	1,412		11,401		Amortization of debt discount	703		1,412

Loss (gain) on disposal of fixed assets		193		(10)
Loss on early extinguishment of debt						Loss on early extinguishment of debt	16,926		—
Loss on disposal of fixed assets						Loss on disposal of fixed assets	—		193
Stock-based compensation	Stock-based compensation	22,733		20,571		Stock-based compensation	22,945		22,733
Changes in contingent consideration	Changes in contingent consideration	(22,351)		(988)		Changes in contingent consideration	(6,640)		(22,351)

Loss on investment	Loss on investment	108		2,601		Loss on investment	11		108
Changes in operating assets and liabilities:	Changes in operating assets and liabilities:					Changes in operating assets and liabilities:
Accounts receivable, net	Accounts receivable, net	5,213		(15,312)		Accounts receivable, net	(683)		5,213
Inventories, net	Inventories, net	(2,038)		(615)		Inventories, net	3,933		(2,038)
Prepaid expenses and other assets	Prepaid expenses and other assets	(3,233)		(944)		Prepaid expenses and other assets	(4,369)		(3,233)
Accounts payable	Accounts payable	5,258		2,156		Accounts payable	9,683		5,258
Accrued expenses and income taxes payable	Accrued expenses and income taxes payable	(19,038)		(18,140)		Accrued expenses and income taxes payable	(30,771)		(19,038)
Other liabilities	Other liabilities	479		(964)		Other liabilities	278		479
Payment of contingent consideration		—		(5,662)

Net cash provided by operating activities	Net cash provided by operating activities	60,583		42,215		Net cash provided by operating activities	62,627		60,583
Investing activities:	Investing activities:					Investing activities:

Purchases of fixed assets	Purchases of fixed assets	(19,403)		(23,624)		Purchases of fixed assets	(9,969)		(19,403)
Purchases of available-for-sale investments	Purchases of available-for-sale investments	(187,641)		(318,132)		Purchases of available-for-sale investments	(69,509)		(187,641)
Sales of available-for-sale investments	Sales of available-for-sale investments	62,936		294,288		Sales of available-for-sale investments	159,745		62,936
Payment of contingent consideration	Payment of contingent consideration	(32,000)		—		Payment of contingent consideration	—		(32,000)
Purchases of equity and debt investments	Purchases of equity and debt investments	(12,750)		(14,220)		Purchases of equity and debt investments	(6,758)		(12,750)
Sale of equity investment		—		9,057

Net cash used in investing activities		(188,858)		(52,631)

Net cash provided by (used in) investing activities						Net cash provided by (used in) investing activities	73,509		(188,858)
Financing activities:	Financing activities:					Financing activities:
Proceeds from exercises of stock options	Proceeds from exercises of stock options	21,881		15,997		Proceeds from exercises of stock options	1,913		21,881
Proceeds from shares issued under employee stock purchase plan	Proceeds from shares issued under employee stock purchase plan	1,821		1,574		Proceeds from shares issued under employee stock purchase plan	1,673		1,821

Proceeds from Term loan A facility						Proceeds from Term loan A facility	149,550		—
Repayment of 2022 convertible senior notes	Repayment of 2022 convertible senior notes	(156,960)		—		Repayment of 2022 convertible senior notes	—		(156,960)
Repayment of 2024 convertible senior notes	Repayment of 2024 convertible senior notes	(192,609)		—		Repayment of 2024 convertible senior notes	—		(192,609)
Repayment of Term loan B facility maturing December 2026		(9,375)		—
Repayment of Term loan B facility						Repayment of Term loan B facility	(296,875)		(9,375)
Repayment of Term loan A facility						Repayment of Term loan A facility	(2,813)		—

Debt extinguishment costs						Debt extinguishment costs	(5,750)		—
Payment of debt issuance and financing costs						Payment of debt issuance and financing costs	(1,163)		—

Payment of contingent consideration to MyoScience, Inc. securityholders		—		(1,338)
Net cash (used in) provided by financing activities		(335,242)		16,233
Net (decrease) increase in cash and cash equivalents		(463,517)		5,817
Net cash used in financing activities						Net cash used in financing activities	(153,465)		(335,242)
Net decrease in cash and cash equivalents						Net decrease in cash and cash equivalents	(17,329)		(463,517)
Cash and cash equivalents, beginning of period	Cash and cash equivalents, beginning of period	585,578		99,957		Cash and cash equivalents, beginning of period	104,139		585,578
Cash and cash equivalents, end of period	Cash and cash equivalents, end of period	$	122,061	$	105,774	Cash and cash equivalents, end of period	$	86,810	$	122,061

Supplemental cash flow information:	Supplemental cash flow information:					Supplemental cash flow information:
Cash paid for interest	Cash paid for interest	$	14,686	$	3,586	Cash paid for interest	$	20,802	$	14,686
Cash paid for income taxes, net of refunds	Cash paid for income taxes, net of refunds	$	4,104	$	1,447	Cash paid for income taxes, net of refunds	$	795	$	4,104
Non-cash investing and financing activities:	Non-cash investing and financing activities:					Non-cash investing and financing activities:
Issuance of common stock from conversion of 2022 convertible senior notes	Issuance of common stock from conversion of 2022 convertible senior notes	$	3,040	$	—	Issuance of common stock from conversion of 2022 convertible senior notes	$	—	$	3,040

Fixed assets included in accounts payable and accrued liabilities	Fixed assets included in accounts payable and accrued liabilities	$	2,454	$	8,096	Fixed assets included in accounts payable and accrued liabilities	$	2,388	$	2,454

See accompanying notes to condensed consolidated financial statements.

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 9

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PACIRA BIOSCIENCES, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

(Unaudited)

NOTE 1—DESCRIPTION OF BUSINESS

Pacira BioSciences, Inc. and its subsidiaries (collectively, the “Company” or “Pacira”) is the industry leader in its commitment to non-opioid pain management and providing a non-opioid ~~option~~pain management options to as many patients as possible to redefine the role of opioids as rescue therapy only. The ~~company~~Company is also developing innovative interventions to address debilitating conditions involving the sympathetic nervous system, such as cardiac electrical storm, chronic pain and spasticity. The Company’s long-acting, local analgesic, EXPAREL® (bupivacaine liposome injectable suspension), was commercially launched in the United States, or U.S., in April 2012 and approved in select European countries and the United Kingdom, or U.K., in November 2021. EXPAREL utilizes the Company’s proprietary multivesicular liposome (pMVL) drug delivery technology that encapsulates drugs without altering their molecular structure, and releases them over a desired period of time. In November 2021, the Company acquired Flexion Therapeutics, Inc., or Flexion (the “Flexion Acquisition”), and added ZILRETTA® (triamcinolone acetonide extended-release injectable suspension) to its product portfolio. ZILRETTA is the first and only extended-release, intra-articular (meaning in the joint) injection indicated for the management of osteoarthritis, or OA, knee pain. ~~For more information, see Note 4,~~ ~~Flexion Acquisition~~. In April 2019, the Company added iovera°® to its commercial offering with the acquisition of MyoScience, Inc., or MyoScience (the “MyoScience Acquisition”). The iovera° system is a handheld cryoanalgesia device used to deliver a precise, controlled application of cold temperature to ~~only~~ targeted nerves.

Pacira is subject to risks common to companies in similar industries and stages, including, but not limited to, competition from larger companies, reliance on revenue from 3three products, reliance on a limited number of wholesalers, reliance on a limited number of manufacturing sites, new technological innovations, dependence on key personnel, reliance on third-party service providers and sole source suppliers, protection of proprietary technology, compliance with government regulations and risks related to cybersecurity.

The Company is managed and operated as a single business focused on the development, manufacture, marketing, distribution and sale of non-opioid pain management and regenerative health solutions. The Company is managed by a single management team, and, consistent with its organizational structure, the Chief Executive ~~Officer and Chairman~~ Officer—who is the Company’s chief operating decision maker—manages and allocates resources at a consolidated level. Accordingly, the Company views its business as 1one reportable operating segment to evaluate its performance, allocate resources, set operational targets and forecast its future financial results.

~~Coronavirus (COVID-19) Pandemic and Global Economic Conditions~~

Since early 2020, the Company’s revenues have been impacted by COVID-19 pandemic-related challenges that included the significant postponement or suspension in the scheduling of elective surgical procedures due to public health guidance and government directives. While the degree of impact has diminished during the course of the pandemic due to the introduction of vaccines and therapeutics, as well as the lessening of elective surgery restrictions, certain pandemic-related operational and staffing challenges persist. It remains unclear how long it will take the elective surgery market to normalize or if restrictions on elective procedures will recur due to future COVID-19 variants or otherwise. Direct effects of the pandemic and global economic conditions may negatively impact the Company’s business, financial condition and results of operations. Such impacts may include the effect of prolonged periods of inflation on the Company’s customers and suppliers and longer lead-times or the inability to secure a sufficient supply of materials. The situation remains dynamic and subject to rapid and possibly material changes. Additional negative impacts may also arise that the Company is unable to foresee. The nature and extent of such impacts will depend on future developments, which are highly uncertain and cannot be predicted.

NOTE 2—SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Basis of Presentation and Principles of Consolidation

These interim condensed consolidated financial statements have been prepared in accordance with generally accepted accounting principles in the United States of America, or GAAP, and in accordance with the rules and regulations of the United States Securities and Exchange Commission (SEC), for interim reporting. Pursuant to these rules and regulations, certain information and footnote disclosures normally included in complete annual financial statements have been condensed or omitted. Therefore, these interim condensed consolidated financial statements should be read in conjunction with the audited annual consolidated financial statements and notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, ~~2021~~2022 (the “2022 Annual Report”).

The condensed consolidated financial statements at June 30, ~~2022,~~2023, and for the three and six-month periods ended June 30, ~~2022~~2023 and ~~2021,~~2022, are unaudited, but include all adjustments (consisting of only normal recurring adjustments) which, in the

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opinion of management, are necessary to present fairly the financial information set forth herein in accordance with GAAP. The condensed consolidated balance sheet at December 31, ~~2021~~2022 is derived from the audited consolidated financial statements included in the Company’s 2022 Annual ~~Report on Form 10-K for the year ended December 31, 2021.~~Report. The condensed consolidated financial statements as presented reflect certain reclassifications from previously issued financial statements to conform to the current year presentation. The accounts of wholly-owned subsidiaries are included in the condensed consolidated financial statements. Intercompany accounts and transactions have been eliminated in consolidation.

The results of operations for these interim periods are not necessarily indicative of results that may be expected for any other interim periods or for the full year.

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Concentration of Major Customers

The Company sells EXPAREL through a drop-ship program under which orders are processed through wholesalers (including AmerisourceBergen Health Corporation, Cardinal Health, Inc. and McKesson Drug Company), but shipments of the product are sent directly to individual accounts, such as hospitals, ambulatory surgery centers and individual doctors. The Company also sells EXPAREL directly to ambulatory surgery centers and physicians. The Company sells ZILRETTA primarily to specialty distributors and a specialty pharmacy, who then subsequently resell ZILRETTA to physicians, clinics and certain medical centers or hospitals. The Company also contracts directly with healthcare providers and intermediaries such as Group Purchasing Organizations, or GPOs. The Company sells ~~iovera° directly to end users and~~ its bupivacaine liposome injectable suspension for veterinary use to a third-party licensee in the U.S. and sells iovera° directly to end users.

The table below includes the percentage of revenues comprised by the Company’s 3three largest wholesalers in each period presented:


		Three Months Ended June 30,		Six Months Ended June 30,			Three Months Ended June 30,		Six Months Ended June 30,
		2022	2021	2022	2021		2023	2022	2023	2022
Largest wholesaler	Largest wholesaler	32%	31%	31%	31%	Largest wholesaler	33%	32%	32%	31%
Second largest wholesaler	Second largest wholesaler	23%	29%	23%	29%	Second largest wholesaler	24%	23%	24%	23%
Third largest wholesaler	Third largest wholesaler	22%	26%	22%	26%	Third largest wholesaler	20%	22%	21%	22%
Total	Total	77%	86%	76%	86%	Total	77%	77%	77%	76%

~~The percentage of revenues from the Company’s 3 largest wholesalers have shifted in the current year with the addition of ZILRETTA sales.~~

~~Recently Adopted Accounting Pronouncements~~

~~In August 2020, the Financial Accounting Standards Board, or FASB, issued Accounting Standards Update, or ASU, 2020-06,~~ ~~Debt—Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging—Contracts in Entity’s Own Equity (Subtopic 815-40),~~ which limits the number of convertible instruments that require separate accounting to (i) those with embedded conversion features that are not clearly and closely related to the debt, that meet the definition of a derivative and that do not qualify for the scope exception from derivative accounting and (ii) convertible debt instruments issued with substantial premiums for which the premiums were recorded as paid in capital. In addition, the new guidance requires diluted earnings per share calculations be prepared using the if-converted method instead of the treasury stock method. The Company elected to adopt the new guidance using a modified retrospective method of transition, which applied to transactions outstanding at January 1, 2022. As a result, the Company does not separately present in equity an embedded conversion feature for its convertible debt. Instead, the Company accounts for its convertible debt instruments wholly as debt. In addition, effective on January 1, 2022, the Company did not record interest expense on the previously recorded discount on its convertible debt. The impact on the condensed consolidated balance sheet at January 1, 2022 increased net debt by approximately $64.9 million, reduced accumulated deficit by $47.2 million, reduced additional paid-in capital by $96.5 million and decreased deferred tax liabilities by $15.7 million.

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NOTE 3—REVENUE

Revenue from Contracts with Customers

The Company’s net product sales consist of (i) EXPAREL in the U.S., the European Union, or E.U., and the U.K.; (ii) ZILRETTA in the U.S.; (iii) iovera° in the U.S., Canada and the E.U. and (iv) sales of ~~and royalties on,~~ its bupivacaine liposome injectable suspension primarily for veterinary use. Royalty revenues are related to a collaborative licensing agreement from the ~~Company’s collaborative licensing agreements.~~sale of its bupivacaine liposome injectable suspension primarily for veterinary use. The Company does not consider revenue from sources other than sales of EXPAREL and ZILRETTA to be material sources of its consolidated revenue. As such, the following disclosure ~~only relates~~is limited to revenue associated with net product sales of EXPAREL and ~~ZILRETTA product sales.~~ZILRETTA.

Net Product Sales

The Company sells EXPAREL through a drop-ship program under which orders are processed through wholesalers based on orders of the product placed by end-users, namely hospitals, ambulatory surgery centers and healthcare provider offices. EXPAREL is delivered directly to the end-user without the wholesaler ever taking physical possession of the product. The Company primarily sells ZILRETTA to specialty distributors and a specialty pharmacy, who then subsequently resell ZILRETTA to physicians, clinics and certain medical centers or hospitals. The Company also contracts directly with healthcare providers and intermediaries such as GPOs. Product revenue is recognized when control of the promised goods are transferred to the customers, in an amount that reflects the consideration the Company expects to be entitled to in exchange for transferring those goods. EXPAREL and ZILRETTA ~~revenue is~~revenues are recorded at the time the ~~product is~~products are transferred to the customer.

Revenues from sales of products are recorded net of returns allowances, prompt payment discounts, service fees, government rebates, volume rebates and chargebacks. These reserves are based on estimates of the amounts earned or to be claimed on the related sales. These amounts are treated as variable consideration, estimated and recognized as a reduction of the transaction price at the time of the sale, using the most likely amount method, except for returns, which is based on the expected value method. The Company includes these estimated amounts in the transaction price to the extent it is probable that a significant reversal of cumulative revenue recognized for such transaction will not occur, or when the uncertainty associated with the variable consideration is resolved.

Chargebacks for fees and discounts to qualified government healthcare providers represent the estimated obligations resulting from contractual commitments to sell products to qualified Department of Veteran Affairs hospitals and 340B entities at prices lower than the list prices charged to other customers. The 340B Drug Discount Program is a U.S. federal government program that requires participating drug manufacturers to provide outpatient drugs to eligible health care organizations and covered entities at reduced prices. Customers charge the Company for the difference between the product payment and the statutory selling price to the qualified entity. Reserves are established in the same period that the related revenue is recognized, resulting in a reduction of product revenue and trade receivables, net. Chargeback amounts are generally determined at the time of sale to the qualified government healthcare provider by customers, and the Company generally issues credits for such

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amounts within weeks of the customer’s notification to the Company of the sale. Reserves for chargebacks consist of credits that the Company expects to issue for units that the Company expects will be sold to qualified healthcare providers, and chargebacks that customers have claimed, but for which the Company has not yet issued a credit.

The calculation offor some of these items requires management to make estimates based on sales data, historical return data, contracts, statutory requirements and other related information that may become known in the future. The adequacy of these provisions is reviewed on a quarterly basis.

Accounts Receivable

The majority of accounts receivable arise from product sales and represent amounts due from wholesalers, hospitals, ambulatory surgery centers, specialty distributors, a specialty pharmacy ~~GPOs~~ and ~~doctors.~~individual physicians. Payment terms generally range from zero to ~~97 days~~four months from the date of the transaction, and accordingly, there is no significant financing component.

Performance Obligations

A performance obligation is a promise in a contract to transfer a distinct good or service to the customer and is the unit of account in Accounting Standards Codification, or ASC, 606. A contract’s transaction price is allocated to each distinct performance obligation and recognized as revenue when, or as, the performance obligation is satisfied.

At contract inception, the Company assesses the goods promised in its contracts with customers and identifies a performance obligation for each promise to transfer to the customer a good that is distinct. When identifying individual performance obligations, the Company considers all goods promised in the contract regardless of whether explicitly stated in the customer contract or implied by customary business practices. The Company’s contracts with customers require it to transfer an individual distinct product, which represents a single performance obligation. The Company’s performance obligation with respect to its product sales is satisfied at a point in time, which transfers control upon delivery of EXPAREL and ZILRETTA to its customers. The Company considers control to have transferred upon delivery because the customer has legal title to the asset, physical possession of the asset has been transferred, the customer has significant risks and rewards of ownership of the asset and the Company has a present right to payment at that time.

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Disaggregated Revenue

The following table represents disaggregated net product sales in the periods presented as follows (in thousands):
Three Months Ended
June 30, Six Months Ended
June 30,
2022 2021 2022 2021
Net product sales:
   EXPAREL $ 137,007 $ 130,058 $ 266,212 $ 244,736
   ZILRETTA 27,417 — 51,052 —
   iovera° 3,201 3,813 6,227 7,081
   Bupivacaine liposome injectable suspension 956 992 2,512 1,784
      Total net product sales $ 168,581 $ 134,863 $ 326,003 $ 253,601


	Three Months Ended June 30,				Six Months Ended June 30,
	2023		2022		2023		2022
Net product sales:
EXPAREL	$	135,127	$	137,007	$	265,535	$	266,212
ZILRETTA	29,261		27,417		53,595		51,052
iovera°	4,384		3,201		8,385		6,227
Bupivacaine liposome injectable suspension	695		956		1,383		2,512
Total net product sales	$	169,467	$	168,581	$	328,898	$	326,003

NOTE 4—~~FLEXION ACQUISITION~~

On November 19, 2021, the Company acquired Flexion (the “Flexion Acquisition”), a biopharmaceutical company focused on the discovery, development, and commercialization of novel, local therapies for the treatment of patients with musculoskeletal conditions, beginning with osteoarthritis, the most common form of arthritis. Upon consummation of the Flexion Acquisition, Flexion became a wholly-owned subsidiary of the Company and was renamed Pacira Therapeutics, Inc.

The total consideration for the Flexion Acquisition was approximately $578.8 million consisting of: (i) $448.5 million of cash paid to former Flexion stockholders and to settle restricted stock units and in-the-money stock options; (ii) an $85.1 million cash payment to repay Flexion debt that was not assumed by the Company and (iii) $45.2 million of estimated contingent consideration related to contingent value rights, or CVRs, that were issued to Flexion shareholders and certain equity award holders in conjunction with the Flexion Acquisition. The consideration is subject to adjustments based on the achievement of certain potential milestone payments. Up to an additional $380.2 million in the aggregate may be payable to holders of the CVRs if each of the applicable milestones are achieved. No contingent consideration milestones were achieved in the six months ended June 30, 2022. ~~See Note~~ 10, ~~Financial Instruments, for information regarding the methodology and key assumptions used in the fair value measurements of contingent consideration and for more information regarding the changes in fair value.~~

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The Company is finalizing its valuation of liabilities and tax analyses, and anticipates finalizing the purchase price allocation as the information necessary to complete the analysis is obtained, but no later than one year after the acquisition date. The following table sets forth the preliminary allocation of the Flexion Acquisition purchase price to the estimated fair value of the net assets acquired at the acquisition date (in thousands):
Amounts Recognized at the Acquisition Date
(as previously
reported) (a)
Measurement Period Adjustments (b)
Amounts Recognized at the Acquisition Date
(as adjusted)
ASSETS ACQUIRED
Cash and cash equivalents $ 113,562 $ — $ 113,562
Short-term available-for-sale investments 11,153 — 11,153
Accounts receivable 32,838 — 32,838
Inventories 29,667 — 29,667
Prepaid expenses and other assets 4,852 — 4,852
Fixed assets 23,307 — 23,307
Deferred tax assets 58,015 — 58,015
Right-of-use assets 6,585 — 6,585
Identifiable intangible assets 480,000 — 480,000
In-process research and development (IPR&D) 61,000 — 61,000
Total assets $ 820,979 $ — $ 820,979
LIABILITIES ASSUMED
Accounts payable $ 9,794 $ — $ 9,794
Accrued expenses 22,746 957 23,703
Deferred revenue 10,000 — 10,000
Lease liabilities 6,585 — 6,585
Other liabilities 1,187 — 1,187
Long-term debt 201,450 — 201,450
Total liabilities 251,762 957 252,719
Total identifiable net assets acquired 569,217 (957) 568,260
Goodwill 9,628 957 10,585
Total consideration transferred $ 578,845 $ — $ 578,845

~~(a) As previously reported in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021.~~

~~(b) Represents pre-acquisition expenses that were paid by the Company in 2022, partially offset by the release of estimated reserves.~~

~~Unaudited Pro Forma Summary of Operations~~

The following table shows the unaudited pro forma summary of operations for the three and six-month periods ended June 30, 2021, as if the Flexion Acquisition had occurred on January 1, 2020. This pro forma information does not purport to represent what the Company’s actual results would have been if the Flexion Acquisition had occurred as of January 1, 2020, and is not indicative of what such results would be expected for any future period (in thousands, except per share amounts):
Three Months Ended
June 30, 2021 Six Months Ended
June 30, 2021
Total revenues $ 163,765 $ 307,381
Net loss $ (3,367) $ (20,487)
Pro forma basic and diluted net loss per share $ (0.08) $ (0.47)

The unaudited pro forma financial information was prepared using the acquisition method of accounting and was based on the historical financial information of the Company and Flexion. The summary pro forma financial information primarily reflects the following pro forma adjustments:

•~~Recognition of the income tax benefit resulting from decreasing Flexion’s existing valuation allowance on deferred tax assets for the three and six months ended June 30, 2021;~~

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•~~Removal of Flexion’s interest expense and associated deferred financing cost amortization related to the $85.1 million of debt not assumed;~~

•~~Adjustments to the Company’s interest income for the cash used to acquire Flexion;~~

•~~Additional cost of goods sold related to a step-up value in inventory;~~

•~~Additional amortization expense from the acquired developed technology intangible assets;~~

•~~Additional depreciation of Flexion’s fixed assets; and~~

•~~Additional lease expense on Flexion’s right-of-use, or ROU, assets.~~

~~In addition, all of the above adjustments were adjusted for the applicable tax impact.~~

~~NOTE 5—~~INVENTORIES

The components of inventories, net are as follows (in thousands):


		June 30,		December 31,			June 30,		December 31,
		2022		2021			2023		2022
Raw materials	Raw materials	$	36,301	$	36,337	Raw materials	$	46,489	$	39,810
Work-in-process	Work-in-process	39,407		35,182		Work-in-process	27,696		28,853
Finished goods	Finished goods	24,880		27,031		Finished goods	17,945		27,400
Total	Total	$	100,588	$	98,550	Total	$	92,130	$	96,063

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NOTE 6—5—FIXED ASSETS

Fixed assets, net, summarized by major category, consist of the following (in thousands):


		June 30,		December 31,			June 30,		December 31,
		2022		2021			2023		2022
Machinery and equipment	Machinery and equipment	$	116,364	$	117,264	Machinery and equipment	$	120,750	$	118,684
Leasehold improvements	Leasehold improvements	60,155		59,740		Leasehold improvements	62,060		61,302
Computer equipment and software	Computer equipment and software	13,598		13,197		Computer equipment and software	16,216		15,360
Office furniture and equipment	Office furniture and equipment	2,303		2,883		Office furniture and equipment	2,382		2,420
Construction in progress	Construction in progress	94,332		80,557		Construction in progress	106,653		103,226
Total	Total	286,752		273,641		Total	308,061		300,992
Less: accumulated depreciation	Less: accumulated depreciation	(95,473)		(85,240)		Less: accumulated depreciation	(127,751)		(117,480)
Fixed assets, net	Fixed assets, net	$	191,279	$	188,401	Fixed assets, net	$	180,310	$	183,512

For the three months ended June 30, ~~2022~~2023 and ~~2021,~~2022, depreciation expense was ~~$6.5~~$4.7 million and ~~$2.9~~$6.5 million, respectively. For the three months ended June 30, ~~2022~~2023 and ~~2021,~~2022, there was ~~$1.0~~$0.7 million and ~~$1.1~~$1.0 million of capitalized interest on the construction of manufacturing sites, respectively.

For the six months ended June 30, ~~2022~~2023 and ~~2021,~~2022, depreciation expense was ~~$12.2~~$10.0 million and ~~$5.8~~$12.2 million, respectively. For the six months ended June 30, ~~2022~~2023 and ~~2021,~~2022, there was ~~$1.8~~$2.1 million and ~~$2.1~~$1.8 million of capitalized interest on the construction of manufacturing sites, respectively.

At June 30, ~~2022~~2023 and December 31, ~~2021,~~2022, total fixed assets, net includes ~~leasehold improvements and~~ manufacturing process equipment and leasehold improvements located in Europe in the amount of ~~$60.0~~$40.6 million and ~~$65.4~~$44.7 million, respectively.

As of June 30, ~~2022~~2023 and December 31, ~~2021,~~2022, the Company had asset retirement obligations of ~~$3.1~~$3.4 million and ~~$2.4~~$3.3 million, respectively, included in accrued expenses and other liabilities on its condensed consolidated balance ~~sheet,~~sheets, for costs associated with returning leased spaces to their original condition upon the termination of certain of its lease agreements.

~~Pacira BioSciences, Inc. | Q2 2022 Form 10-Q | Page 15~~

~~Table of Contents~~

NOTE 7—6—LEASES

The Company leases all of its facilities, including its EXPAREL and iovera° handpiece manufacturing facility at its Science Center Campus in San Diego, California. ~~These leases have remaining terms up to 8.2 years, some of which provide renewal options at the then-current market value.~~ The Company also has 2two embedded leases with Thermo Fisher Scientific Pharma Services for the use of their manufacturing facility in Swindon, England for the production of EXPAREL and ZILRETTA. A portion of the associated monthly base fees has been allocated to the lease components based on a relative fair value basis.

Since July 2022 and February 2023, the Company has been recognizing sublease income for laboratory space leased in Woburn, Massachusetts and a portion of office space leased in Burlington, Massachusetts, respectively, from leases that were assumed as part of the Flexion Acquisition.

Subsequent to June 30, 2023, the Company partially exited its Burlington, Massachusetts office space lease that had been assumed as part of the Flexion Acquisition at a one-time termination fee of $0.8 million, which released its obligation of $1.6 million in future cash payments for the respective proportion of square footage exited.

The operating lease costs for the facilities include lease and non-lease components, such as common area maintenance and other common operating expenses, along with executory costs such as insurance and real estate taxes. Total operating lease ~~costs are~~expense, net is as follows (in thousands):


		Three Months Ended				Six Months Ended					Three Months Ended				Six Months Ended
		June 30,				June 30,					June 30,				June 30,
		2022		2021		2022		2021			2023		2022		2023		2022
Fixed lease costs	Fixed lease costs	$	3,542	$	2,922	$	7,069	$	5,843	Fixed lease costs	$	3,631	$	3,542	$	7,259	$	7,069
Variable lease costs	Variable lease costs	508		424		980		902		Variable lease costs	378		508		945		980
Sublease income										Sublease income	(169)		—		(322)		—
Total	Total	$	4,050	$	3,346	$	8,049	$	6,745	Total	$	3,840	$	4,050	$	7,882	$	8,049

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Supplemental cash flow information related to operating leases is as follows (in thousands):

Six Months Ended
June 30,
2022 2021
Cash paid for operating lease liabilities, net of lease incentive $ 6,637 $ 7,177
ROU assets recorded in exchange for lease obligations $ — $ —


	Six Months Ended
	June 30,
	2023		2022
Cash paid for operating lease liabilities, net of lease incentives	$	7,325	$	6,637

The Company has elected to net the amortization of the ~~ROU~~right-of-use asset and the reduction of the lease liability principal in other liabilities in the condensed consolidated ~~statement~~statements of cash flows.

The Company has measured its operating lease liabilities at an estimated discount rate at which it could borrow on a collateralized basis over the remaining term for each operating lease. The weighted average remaining lease ~~term~~terms and the weighted average discount ~~rate~~rates are summarized as follows:


		June 30,					June 30,
		2022		2021			2023		2022
Weighted average remaining lease term	Weighted average remaining lease term	7.33 years		8.71 years		Weighted average remaining lease term	6.39 years		7.33 years
Weighted average discount rate	Weighted average discount rate	6.95	%	6.89	%	Weighted average discount rate	7.03	%	6.95	%

Maturities of the Company’s operating lease liabilities are as follows (in thousands):


Year	Year	Aggregate Minimum Payments Due		Year	Aggregate Minimum Payments Due
2022 (remaining six months)		$	6,509
2023		13,304
2023 (remaining six months)				2023 (remaining six months)	$	6,925
2024	2024	13,435		2024	13,928
2025	2025	12,575		2025	13,078
2026	2026	12,310		2026	12,814
2027				2027	12,587
Thereafter	Thereafter	39,422		Thereafter	27,350
Total future lease payments	Total future lease payments	97,555		Total future lease payments	86,682
Less: imputed interest	Less: imputed interest	(21,846)		Less: imputed interest	(17,655)
Total operating lease liabilities	Total operating lease liabilities	$	75,709	Total operating lease liabilities	$	69,027

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 1614

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As of June 30, 2022, the Company has entered into 1 lease agreement not included above as the Company has not yet taken possession of the property. When the lease commences, the future lease obligations will be as follows (in thousands):

Year Aggregate Minimum Payments Due
2022 (remaining six months) $ 81
2023 492
2024 494
2025 503
2026 505
Thereafter 443
Total future lease payments $ 2,518

Subsequent to June 30, 2022, the Company entered into a sublease for the former Flexion research and development laboratory in Woburn, Massachusetts in July 2022 which resulted in a $0.4 million ROU asset to be reclassified to a fixed asset.

NOTE 8—7—GOODWILL AND INTANGIBLE ASSETS

Goodwill

The Company’s goodwill results from the acquisition of Pacira Pharmaceuticals, Inc. (the Company’s California operating subsidiary) from SkyePharma Holding, Inc., or Skyepharma, (now a subsidiary of Vectura Group plc) in ~~March~~ 2007 (the “Skyepharma Acquisition”), the MyoScience ~~Inc., or MyoScience, (the “MyoScience Acquisition”)~~Acquisition in ~~April~~ 2019 and the Flexion Acquisition in ~~November~~ 2021. The ~~balances~~balance at each of June 30, ~~2022~~2023 and December 31, ~~2021 were $146.1 million and $145.2 million, respectively. The increase~~2022 was ~~due to measurement period adjustments associated with the Flexion Acquisition. See Note 4,~~ ~~Flexion Acquisition,~~ ~~for more information.~~$163.2 million.

The Skyepharma Acquisition occurred in March 2007, prior to the requirements to record contingent consideration at fair value under ASC 805-30. In connection with the Skyepharma Acquisition, the Company agreed to certain milestone payments for DepoBupivacaine products, including EXPAREL. The final Skyepharma milestone payment of $32.0 million when annual net sales collected reached $500.0 million was achieved in the fourth quarter of 2021 and paid during the first quarter of 2022.

Intangible Assets

Intangible assets, net, ~~consist~~consists of the in-process research and development, or IPR&D, and developed technology from the Flexion Acquisition and developed technology and customer relationships from the MyoScience Acquisition and are summarized as follows (dollar amounts in thousands):


June 30, 2022		Gross Carrying Value		Accumulated Amortization		Intangible Assets, Net		Weighted-Average Useful Lives
June 30, 2023									June 30, 2023	Gross Carrying Value		Accumulated Amortization		Intangible Assets, Net		Weighted-Average Useful Lives
Developed technologies	Developed technologies	$	590,000	$	(55,737)	$	534,263	10 years, 5 months	Developed technologies	$	590,000	$	(113,016)	$	476,984	10 years, 5 months
Customer relationships	Customer relationships	90		(29)		61		10 years	Customer relationships	90		(38)		52		10 years
Total finite-lived intangible assets, net	Total finite-lived intangible assets, net	590,090		(55,766)		534,324			Total finite-lived intangible assets, net	590,090		(113,054)		477,036
Acquired IPR&D	Acquired IPR&D	61,000		—		61,000			Acquired IPR&D	34,866		—		34,866
Total intangible assets, net	Total intangible assets, net	$	651,090	$	(55,766)	$	595,324		Total intangible assets, net	$	624,956	$	(113,054)	$	511,902

December 31, 2021		Gross Carrying Value		Accumulated Amortization		Intangible Assets, Net		Weighted-Average Useful Lives
December 31, 2022									December 31, 2022	Gross Carrying Value		Accumulated Amortization		Intangible Assets, Net		Weighted-Average Useful Lives
Developed technologies	Developed technologies	$	590,000	$	(27,097)	$	562,903	10 years, 5 months	Developed technologies	$	590,000	$	(84,376)	$	505,624	10 years, 5 months
Customer relationships	Customer relationships	90		(25)		65		10 years	Customer relationships	90		(34)		56		10 years
Total finite-lived intangible assets, net	Total finite-lived intangible assets, net	590,090		(27,122)		562,968			Total finite-lived intangible assets, net	590,090		(84,410)		505,680
Acquired IPR&D	Acquired IPR&D	61,000		—		61,000			Acquired IPR&D	34,866		—		34,866
Total intangible assets, net	Total intangible assets, net	$	651,090	$	(27,122)	$	623,968		Total intangible assets, net	$	624,956	$	(84,410)	$	540,546

Amortization expense on intangible assets was $14.3 million for both the three months ended June 30, 2023 and 2022. Amortization expense on intangible assets was $28.6 million for both the six months ended June 30, ~~2022 was $14.3 million~~2023 and ~~$28.6 million, respectively. Amortization expense on intangible assets for the three and six months ended June 30, 2021 was~~

~~Pacira BioSciences, Inc. | Q2 2022 Form 10-Q | Page 17~~

~~Table of Contents~~

$2.0 million and $3.9 million, respectively. The increase in amortization expense in the current year is a result of the amortization of ZILRETTA for osteoarthritis knee pain acquired as part of the Flexion Acquisition in November 2021.2022.

Assuming no changes in the gross carrying amount of these intangible assets, the future estimated amortization expense on the finite-lived intangible assets will be $28.6 million for the remaining six months of ~~2022,~~2023, $57.3 million each year from ~~2023~~2024 to 2030, $37.4 million in 2031, $7.9 million in 2032 and $2.2 million in 2033.

~~The Company reviews its long-lived assets for impairment whenever an event or change in circumstances arise that indicate the carrying amount~~

Pacira BioSciences, Inc. | Q2 2023 Form 10-Q | Page 15

Table of an asset group is at risk of not being recoverable. A triggering event was identified for the ZILRETTA asset group due to a reduction in the near-term projected cash flows from the ZILRETTA product. The Company completed an impairment assessment through a recoverability test at June 30, 2022 by comparing the net carrying value of ZILRETTA asset group against the undiscounted net cash flows expected to be generated from ZILRETTA. It was determined that the ZILRETTA asset group was recoverable and not impaired.Contents

NOTE 9—8—DEBT

The carrying value of the Company’s outstanding debt is summarized as follows (in thousands):
June 30, December 31,
2022 2021
Term loan B facility maturing December 2026 $ 352,120 $ 359,497
0.750% Convertible senior notes due August 2025 394,894 330,627
3.375% Convertible senior notes due May 2024 8,640 201,249
2.375% Convertible senior notes due April 2022 (1)
— 157,857
Total $ 755,654 $ 1,049,230


	June 30,		December 31,
	2023		2022
Term loan A facility maturing March 2028	$	145,686	$	—
Term loan B facility maturing December 2026 (1)	—		284,704
0.750% Convertible senior notes due August 2025	397,360		396,126
3.375% Convertible senior notes due May 2024	8,641		8,641
Total	$	551,687	$	689,471

(1) The ~~2022 Notes~~TLB Term Loan (as defined below) ~~matured~~was refinanced on ~~April 1, 2022.~~March 31, 2023 as discussed below.

2028 Term Loan BA Facility

~~In December 2021,~~On March 31, 2023, the Company entered into a ~~term loan~~ credit agreement (the ~~“Credit~~“TLA Credit Agreement”) with ~~JP Morgan~~JPMorgan Chase Bank, N.A., as administrative agent, and certain lenders, to refinance the ~~initial lender.~~indebtedness outstanding under the Company’s TLB Credit Agreement (as defined and discussed below). The term loan issued under the TLA Credit Agreement (the ~~“Term~~“TLA Term Loan”) was issued at a 3%0.30% discount and ~~allows~~provides for a single-advance term loan BA facility in the principal amount of ~~$375.0~~$150.0 million, which is secured by substantially all of the Company’s and ~~each~~any subsidiary guarantor’s assets. Subject to certain conditions, the Company may, at any time, on one or more occasion, add one or more new classes of term facilities and/or increase the principal amount of the loans of any existing class by requesting one or more incremental term facilities. The net proceeds of the TLA Term Loan were approximately ~~$363.8~~$149.6 million after deducting an original issue discount of ~~$11.2~~$0.4 million.

The total debt composition of the TLA Term Loan is as follows (in thousands):
June 30, December 31,
2022 2021
Term Loan maturing December 2026 $ 365,625 $ 375,000
Deferred financing costs (3,856) (4,443)
Discount on debt (9,649) (11,060)
Total debt, net of debt discount and deferred financing costs $ 352,120 $ 359,497


	June 30,
	2023
Term loan A facility maturing March 2028	$	147,188
Deferred financing costs	(1,079)
Discount on debt	(423)
Total debt, net of debt discount and deferred financing costs	$	145,686

The TLA Term Loan matures on ~~December 7, 2026~~March 31, 2028 and requires quarterly repayments of principal in the amount of ~~$9.4~~$2.8 million which commenced on June 30, 2023, increasing to $3.8 million commencing ~~June 30, 2022, increasing to $14.1 million commencing December~~March 31, 2025, with a remaining balloon payment of approximately ~~$188.0~~$85.3 million due at maturity. During ~~2022,~~the remainder of 2023, the Company is required to make 3two more quarterly principal payments totaling ~~$28.1~~$5.6 million.

The Company is also required to make mandatory prepayments of principal from (i) the Company’s excess cash flow (as defined in the Credit Agreement) existing in any fiscal year and if the Senior Secured Leverage Ratio (as defined in the Credit Agreement) for such fiscal year exceeds certain predetermined limits (ii) net proceeds (as defined in the Credit Agreement) of non-ordinary course assets sales and casualty events and (iii) debt issuance proceeds (other than permitted debt under the Credit Agreement). Prepayment penalties for the Term Loan are 2% in the first loan year plus an interest make-whole payment, 2% in the second loan year, 1% in the third loan year and nothing thereafter. Prepayment penalties generally do not apply to mandatory prepayment obligations under theTLA Credit Agreement ~~such as prepayments due in connection with excess cash flow. During the three and six months ended June 30, 2022, the Company made a scheduled principal payment of $9.4 million.~~

~~Pacira BioSciences, Inc. | Q2 2022 Form 10-Q | Page 18~~

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~~The Term Loan~~ requires the Company to, among other things, maintain (i) a ~~first lien net leverage ratio,~~Senior Secured Net Leverage Ratio (as defined in the TLA Credit Agreement), determined as of the last day of ~~any~~each fiscal quarter, of no greater than ~~1.75~~3.00 to 1.00 and (ii) ~~liquidity, at any time,~~a Fixed Charge Coverage Ratio (as defined in the Credit Agreement), determined as of ~~at least $150.0 million.~~the last day of each fiscal quarter, of no less than 1.50 to 1.00. The ~~Term Loan~~TLA Credit Agreement also contains customary affirmative and negative covenants, financial covenants, representations and warranties, events of default and other provisions. As of June 30, ~~2022,~~2023, the Company was in compliance with all financial covenants under the TLA Credit Agreement.

The Company may elect to borrow either (i) alternate base rate borrowings or (ii) term benchmark borrowings or daily simple SOFR (as defined in the TLA Credit Agreement) borrowings. Each term loan borrowing that is an alternate base rate ~~borrowings. Term benchmark borrowings bear~~borrowing bears interest at a ~~variable~~ rate per annum equal to (i) the Alternate Base Rate (as defined in the TLA Credit Agreement), plus (ii) a spread based on the Company’s Senior Secured Net Leverage Ratio ranging from 2.00% to 2.75%. Each term loan borrowing that is a term benchmark borrowing or daily simple SOFR borrowing bears interest at a rate per annum equal to (i) the Adjusted Term SOFR Rate or Adjusted Daily Simple SOFR (as each is defined in the Credit Agreement) ~~(subject~~, plus (ii) a spread based on the Company’s Senior Secured Net Leverage Ratio ranging from 3.00% to 3.75%. During the six months ended June 30, 2023, the Company made a ~~75 basis points floor) plus an applicable margin~~scheduled principal payment of 700 basis points. Alternate base rate borrowings bear interest at a variable rate per annum determined using a base rate (subject to a 175 basis points floor) equal to the greatest of (i) the Prime Rate (as defined in the Credit Agreement) in effect on such day, (ii) the NYFRB Rate (as defined in the Credit Agreement) plus 50 basis points or (iii) the Adjusted Term SOFR Rate (as defined in the Credit Agreement) plus 100 basis points, subject to certain exceptions, plus an applicable margin of 600 basis points.$2.8 million. As of June 30, ~~2022,~~2023, borrowings under the TLA Term Loan consisted entirely of term benchmark borrowings at a rate of ~~7.81%~~8.01%. Subsequent to June 30, 2023, the Company made a $25.0 million principal prepayment in July 2023.

Pacira BioSciences, Inc. | Q2 2023 Form 10-Q | Page 16

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2026 Term Loan B Facility

In December 2021, the Company entered into a term loan credit agreement (the “TLB Credit Agreement”) with JPMorgan Chase Bank, N.A., as administrative agent and the initial lender. The term loan issued under the Credit Agreement (the “TLB Term Loan”) was issued at a 3.00% discount and allowed for a single-advance term loan B facility in the principal amount of $375.0 million, which was secured by substantially all of the Company’s and each subsidiary guarantor’s assets. The net proceeds of the TLB Term Loan were approximately $363.8 million after deducting an original issue discount of $11.2 million.

On March 31, 2023, the Company used the $149.6 million of net borrowings under the TLA Credit Agreement and cash on hand to repay the indebtedness outstanding under the TLB Credit Agreement and concurrently terminated the TLB Credit Agreement. The Company incurred a prepayment fee of 2.00% of the outstanding principal balance of the TLB Term Loan in connection with the termination.

The total debt composition of the TLB Term Loan was as follows (in thousands):


	June 30,		December 31,
	2023		2022
Term loan B facility maturing December 2026	$	—	$	296,875
Deferred financing costs	—		(3,919)
Discount on debt	—		(8,252)
Total debt, net of debt discount and deferred financing costs	$	—	$	284,704

During the six months ended June 30, 2023, the Company made a scheduled principal payment of $9.4 million and repaid the outstanding $287.5 million principal on the TLB Term Loan, which resulted in a $16.9 million loss on early extinguishment of debt.

Convertible Senior Notes Due 2025

In July 2020, the Company completed a private placement of $402.5 million in aggregate principal amount of its 0.750% convertible senior notes due 2025, or 2025 Notes, and entered into an indenture with Computershare Corporate Trust, N.A. (formerly Wells Fargo Bank, N.A.), or 2025 Indenture, with respect to the 2025 Notes. The 2025 Notes accrue interest at a fixed rate of 0.750% per year, payable semiannually in arrears on February 1st and August 1st of each year. The 2025 Notes mature on August 1, 2025.

The total debt composition of the 2025 Notes is as follows (in thousands):


		June 30,		December 31,			June 30,		December 31,
		2022		2021			2023		2022
0.750% convertible senior notes due August 2025	0.750% convertible senior notes due August 2025	$	402,500	$	402,500	0.750% convertible senior notes due August 2025	$	402,500	$	402,500
Deferred financing costs	Deferred financing costs	(7,606)		(7,155)		Deferred financing costs	(5,140)		(6,374)
Discount on debt		—		(64,718)

Total debt, net of debt discount and deferred financing costs	Total debt, net of debt discount and deferred financing costs	$	394,894	$	330,627	Total debt, net of debt discount and deferred financing costs	$	397,360	$	396,126

The net proceeds from the issuance of the 2025 Notes were approximately $390.0 million, after deducting commissions and the offering expenses paid by the Company. A portion of the net proceeds from the 2025 Notes was used by the Company to repurchase $185.0 million in aggregate principal amount of its then-outstanding 2.375% convertible senior notes due 2022 in privately-negotiated transactions for a total of $211.1 million of cash (including accrued interest).

Holders may convert the 2025 Notes at any time prior to the close of business on the business day immediately preceding February 3, 2025, only if certain circumstances are met, including if during the previous calendar quarter, the last reported sales price of the Company’s common stock was greater than 130% of the conversion price then applicable for at least 20 out of the last 30 consecutive trading days of the quarter. During the quarter ended June 30, ~~2022, this condition~~2023, the conditions for conversion ~~was~~were not met.

On or after February 3, 2025, until the close of business on the second scheduled trading day immediately preceding August 1, 2025, holders may convert their 2025 Notes at any time.

Upon conversion, holders will receive the principal amount of their 2025 Notes and any excess conversion value, calculated based on the per share volume-weighted average price for each of the 40 consecutive trading days during the observation period (as more fully described in the 2025 Indenture). For both the principal and excess conversion value, holders may receive cash, shares of the Company’s common stock or a combination of cash and shares of the Company’s common stock, at the Company’s option. The initial conversion rate for the 2025 Notes is 13.9324 shares of common stock per $1,000

Pacira BioSciences, Inc. | Q2 2023 Form 10-Q | Page 17

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principal amount, which is equivalent to an initial conversion price of $71.78 per share of the Company’s common stock. The conversion rate will be subject to adjustment in some events but will not be adjusted for any accrued and unpaid interest. The initial conversion price of the 2025 Notes represents a premium of approximately 32.5% to the closing sale price of $54.17 per share of the Company’s common stock on the Nasdaq Global Select Market on July 7, 2020, the date that the Company priced the private offering of the 2025 Notes.

As of June 30, ~~2022,~~2023, the 2025 Notes had a market price of ~~$1,038~~$926 per $1,000 principal amount. In the event of conversion, holders would forgo all future interest payments, any unpaid accrued interest and the possibility of further stock price appreciation. Upon the receipt of conversion requests, the settlement of the 2025 Notes will be paid pursuant to the terms of the 2025 Indenture. In the event that all of the 2025 Notes are converted, the Company would be required to repay the

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~~Table of Contents~~

~~$402.5~~ $402.5 million in principal value and any conversion premium in any combination of cash and shares of its common stock (at the Company’s option).

~~Prior to August 1, 2023, the Company may not redeem the 2025 Notes. On or after~~Beginning on August 1, 2023 (but, in the case of a redemption of less than all of the outstanding 2025 Notes, no later than the 40th scheduled trading day immediately before the maturity date), the Company may redeem for cash all or part of the 2025 Notes if the last reported sale price (as defined in the 2025 Indenture) of the Company’s common stock has been at least 130% of the conversion price then in effect for (i) each of at least 20 trading days (whether or not consecutive) during any 30 consecutive trading days ending on, and including, the trading day immediately before the date the Company sends the related notice of redemption and (ii) the trading day immediately before the date the Company sends such notice. The redemption price will equal the sum of (i) 100% of the principal amount of the 2025 Notes being redeemed, plus (ii) accrued and unpaid interest, including additional interest, if any, to, but excluding, the redemption date. In addition, calling the 2025 Notes for redemption will constitute a “make-whole fundamental change” (as defined in the 2025 Indenture) and will, in certain circumstances, increase the conversion rate applicable to the conversion of such notes if it is converted in connection with the redemption. No sinking fund is provided for the 2025 Notes.

While the 2025 Notes are currently classified on the Company’s condensed consolidated balance sheet at June 30, ~~2022~~2023 as long-term debt, the future convertibility and resulting balance sheet classification of this liability is monitored at each quarterly reporting date and is analyzed dependent upon market prices of the Company’s common stock during the prescribed measurement periods. In the event that the holders of the 2025 Notes have the election to convert the 2025 Notes at any time during the prescribed measurement period, the 2025 Notes would then be considered a current obligation and classified as such.

Convertible Senior Notes Due 2024 Assumed from the Flexion Acquisition

Prior to the Flexion Acquisition, on May 2, 2017, Flexion issued an aggregate of $201.3 million principal amount of 3.375% convertible senior notes due 2024 (the “Flexion 2024 Notes”), pursuant to the indenture, dated as of May 2, 2017 (the “Original Flexion Indenture”), between Flexion and Computershare Corporate Trust, N.A. (formerly Wells Fargo Bank, N.A.), as trustee (the “Flexion Trustee”), as supplemented by the First Supplemental Indenture, dated as of November 19, 2021, between Flexion and the Flexion Trustee (the “First Supplemental Flexion Indenture” and, together with the Original Flexion Indenture, the “Flexion Indenture”). The Flexion 2024 Notes ~~have a maturity date of~~mature on May 1, 2024, are unsecured and accrue interest at a rate of 3.375% per annum, payable semi-annually on May 1st and November 1st of each year. Upon the Flexion Acquisition, the principal was assumed and recorded at fair value by the Company.

Upon conversion of the Flexion 2024 Notes, at the election of each holder thereof, each Flexion 2024 Note was convertible into cash, shares of Flexion’s common stock, or a combination thereof, at Flexion’s election, at a conversion rate of approximately 37.3413 shares of Flexion common stock per $1,000 principal amount of the Flexion 2024 Notes, which corresponded to an initial conversion price of approximately $26.78 per share of Flexion’s common stock. As a result of the Flexion Acquisition, and in connection with the Notice (as defined below), holders of the Flexion 2024 Notes became entitled to certain Flexion Acquisition-related conversion and repurchase rights, as discussed below. In addition, as a result of the Flexion Acquisition and as discussed in more detail below, any future conversion rights are subject to the occurrence of any future events giving rise to such conversion rights under the Flexion Indenture.

~~On December 6, 2021, as a result of the Flexion Acquisition and in accordance with the Flexion Indenture, Flexion provided~~ a Fundamental Change Company Notice and Offer to Purchase (the “Notice”) to the holders of the Flexion 2024 Notes in accordance with the Flexion Indenture, holders of the Flexion 2024 Notes became entitled to certain Flexion Acquisition-related conversion and repurchase rights. On December 6, 2021, as a result of the Flexion Acquisition and in accordance with the Flexion Indenture, the Company offered to repurchase for cash all of the outstanding Flexion 2024 Notes, at a repurchase price in cash equal to 100% of the principal amount of the Flexion 2024 Notes being repurchased, plus accrued and unpaid interest thereon to, but excluding, January 7, 2022, subject to the terms and conditions set forth therein. ~~The offer to purchase expired at 5:00 p.m., New York City time, on January 6, 2022, as scheduled.~~

Any holder that did not exercise its repurchase right in accordance with the terms of the Notice retained the conversion rights associated with such holder’s Flexion 2024 Notes under the Flexion ~~Indenture. For conversion of Flexion 2024 Notes in connection with~~Indenture as well as the Fundamental Change and the Make-Whole Fundamental Change (each as defined in the Flexion Indenture) resulting from the Flexion Acquisition, each $1,000 principal amount of the Flexion 2024 Notes was convertible into (i) $317.40 in cash and (ii) 37.3413 CVRs, based on the conversion rate of 37.3413, prior to 5:00 p.m., New York City time, on January 7, 2022. Alternatively, holders could retain their Flexion 2024 Notes and such Flexion 2024 Notes would remain outstanding subject to their existing terms, including with respect to a holder’s right to receive interest payments on the Flexion 2024 ~~Notes and exercise any future conversion rights that may arise under the Flexion Indenture.~~Notes.

On January 7, 2022, following the expiration of the offer to purchase, the Company accepted the $192.6 million aggregate principal amount of Flexion 2024 Notes that were validly tendered (and not validly withdrawn). No Flexion 2024 Notes were converted in connection with the Notice. At June 30, ~~2022,~~2023, the remaining principal outstanding is $8.6 million.

~~Pacira BioSciences, Inc. | Q2 2022 Form 10-Q | Page 20~~

~~Table of Contents~~

Convertible Senior Notes Due 2022

In March 2017, the Company completed a private placement of $345.0 million in aggregate principal amount of 2.375% convertible senior notes due 2022, or 2022 ~~Notes. The 2022~~ Notes, ~~accrued interest at a fixed rate of 2.375% per year, payable semiannually in arrears on April 1~~stand ~~October 1~~st ~~of each year. In July 2020, the Company used part of the net proceeds from the issuance of the 2025 Notes~~entered into an indenture with respect to ~~repurchase $185.0 million aggregate principal amount of~~ the 2022 ~~Notes in privately-negotiated transactions for an aggregate of $211.1 million in cash (including accrued interest).~~

~~The total debt composition of the 2022 Notes is as follows (in thousands):~~
June 30, December 31,
2022 2021
2.375% convertible senior notes due April 2022 $ — $ 160,000
Deferred financing costs — (223)
Discount on debt — (1,920)
Total debt, net of debt discount and deferred financing costs $ — $ 157,857

Notes. On April 1, 2022, the 2022 Notes matured and the Company settled the remaining outstanding principal balance of $160.0 million and a

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conversion premium of $4.8 million through a cash payment of $156.9 million and the issuance of 101,521 shares of the Company’s common stock, which increased additional paid-in capital by $3.0 million.

Interest Expense

The following table sets forth the total interest expense recognized in the periods presented (dollar amounts in thousands):

Three Months Ended
June 30, Six Months Ended
June 30,
2022 2021 2022 2021
Contractual interest expense $ 8,196 $ 1,713 $ 17,381 $ 3,418
Amortization of debt issuance costs 874 659 2,053 1,310
Amortization of debt discount 706 5,744 1,412 11,401
Capitalized interest and other (Note 6) (943) (1,093) (1,767) (2,135)
Total $ 8,833 $ 7,023 $ 19,079 $ 13,994
Effective interest rate on total debt 5.08 % 6.70 % 5.31 % 6.70 %

Upon the adoption of ASU 2020-06 effective January 1, 2022, the Company eliminated the convertible debt discounts associated with the 2022 Notes and the 2025 Notes that were originally recorded as offsets to the embedded conversion features recognized in equity. Effective January 1, 2022, the Company will not record interest expense on the previously recorded discounts on convertible debt. The deferred financing costs previously allocated to the conversion features have since been re-allocated to the outstanding debt, slightly increasing the future annual amortization of deferred financing costs. For additional information regarding the adoption of ASU 2020-06, see Note 2~~, Summary of Significant Accounting Policies~~.


	Three Months Ended June 30,						Six Months Ended June 30,
	2023			2022			2023			2022
Contractual interest expense	$	3,849		$	8,196		$	13,199		$	17,381
Amortization of debt issuance costs	691			874			1,628			2,053
Amortization of debt discount	28			706			703			1,412
Capitalized interest and other (Note 5)	(703)			(943)			(2,076)			(1,767)
Total	$	3,865		$	8,833		$	13,454		$	19,079

Effective interest rate on total debt	3.16		%	5.08		%	4.38		%	5.31		%

NOTE ~~10—~~9—FINANCIAL INSTRUMENTS

Fair Value Measurements

Fair value is defined as the price that would be received to sell an asset or be paid to transfer a liability in the principal or most advantageous market in an orderly transaction. To increase consistency and comparability in fair value measurements, the ~~FASB~~Financial Accounting Standards Board (FASB) established a three-level hierarchy which requires an entity to maximize the use of observable inputs and minimize the use of unobservable inputs when measuring fair value. The three levels of fair value measurements are:

•Level 1: Quoted prices (unadjusted) in active markets that are accessible at the measurement date for assets or liabilities. The fair value hierarchy gives the highest priority to Level 1 inputs.

•Level 2: Observable prices that are based on inputs not quoted on active markets, but corroborated by market data.

•Level 3: Unobservable inputs that are used when little or no market data is available. The fair value hierarchy gives the lowest priority to Level 3 inputs.

~~Pacira BioSciences, Inc. | Q2 2022 Form 10-Q | Page 21~~

~~Table of Contents~~

The carrying value of financial instruments including cash and cash equivalents, accounts receivable and accounts payable approximate their respective fair values due to the short-term nature of these items. The fair value of the Company’s convertible senior notes are calculated utilizing market quotations from an over-the-counter trading market for these notes (Level 2). The fair value of the Company’s acquisition-related contingent consideration is reported at fair value on a recurring basis (Level 3). The carrying amounts of equity investments and convertible notes receivable without readily determinable fair values have not been adjusted for either an impairment or upward or downward adjustments based on observable transactions.

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At June 30, ~~2022,~~2023, the carrying values and fair values of the following financial assets and liabilities were as follows (in thousands):


		Carrying Value		Fair Value Measurements Using							Carrying Value		Fair Value Measurements Using
				Level 1		Level 2		Level 3					Level 1		Level 2		Level 3
Financial Assets and Financial Liabilities Measured at Fair Value on a Recurring Basis:	Financial Assets and Financial Liabilities Measured at Fair Value on a Recurring Basis:									Financial Assets and Financial Liabilities Measured at Fair Value on a Recurring Basis:
Financial Assets:	Financial Assets:									Financial Assets:
Equity investments	Equity investments	$	25,627	$	—	$	—	$	25,627	Equity investments	$	15,877	$	—	$	—	$	15,877
Convertible notes receivable	Convertible notes receivable	$	5,299	$	—	$	—	$	5,299	Convertible notes receivable	$	12,062	$	—	$	—	$	12,062
Financial Liabilities:	Financial Liabilities:									Financial Liabilities:
Acquisition-related contingent consideration	Acquisition-related contingent consideration	$	35,247	$	—	$	—	$	35,247	Acquisition-related contingent consideration	$	21,482	$	—	$	—	$	21,482

Financial Liabilities Measured at Amortized Cost:	Financial Liabilities Measured at Amortized Cost:									Financial Liabilities Measured at Amortized Cost:
Term loan facility due December 2026		$	352,120	$	—	$	366,562.5	$	—
Term loan A facility due March 2028										Term loan A facility due March 2028	$	145,686	$	—	$	146,452	$	—
0.750% convertible senior notes due 2025 (1)	0.750% convertible senior notes due 2025 (1)	$	394,894	$	—	$	417,855	$	—	0.750% convertible senior notes due 2025 (1)	$	397,360	$	—	$	372,566	$	—
3.375% convertible senior notes due 2024 ~~(2)~~	3.375% convertible senior notes due 2024 ~~(2)~~	$	8,640	$	—	$	8,606	$	—	3.375% convertible senior notes due 2024 ~~(2)~~	$	8,641	$	—	$	8,641	$	—

(1) The closing price of the Company’s common stock as reported on the Nasdaq Global Select Market was ~~$58.30~~$40.07 per share at June 30, ~~2022~~2023 compared to a conversion price of $71.78 per share. ~~Therefore, at~~At June 30, ~~2022,~~2023, as the conversion price was above the stock ~~price.~~price, the requirements for conversion have not been met. The maximum conversion premium that could have been due on the 2025 Notes is 5.6 million shares of the Company’s common stock, which assumes no increase in the conversion rate for certain corporate events.

~~(2) Relates to the Flexion 2024 Notes. For more information, See Note 9,~~ ~~Debt~~.Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis

Equity and Convertible Note Investments

The Company holds strategic investments in clinical and preclinical stage privately-held biotechnology companies in the form of equity and convertible note investments. The following investments have no readily determinable fair value and are recorded at cost minus impairment, if any, plus or minus observable price changes of identical or similar investments (in thousands):

Equity Investments Convertible Notes Receivable Total
Balance at December 31, 2021 $ 14,127 $ 4,132 $ 18,259
Purchases 11,500 1,250 12,750
Foreign currency adjustments — (83) (83)
Balance at June 30, 2022 $ 25,627 $ 5,299 $ 30,926

~~Pacira BioSciences, Inc. | Q2 2022 Form 10-Q | Page 22~~

~~Table of Contents~~


	Equity Investments		Convertible Notes Receivable		Total
Balance at December 31, 2021	$	14,127	$	4,132	$	18,259
Purchases	11,750		1,250		13,000
Impairment	(10,000)		—		(10,000)
Foreign currency adjustments	—		(67)		(67)
Balance at December 31, 2022	15,877		5,315		21,192
Purchases	—		6,758		6,758

Foreign currency adjustments	—		(11)		(11)
Balance at June 30, 2023	$	15,877	$	12,062	$	27,939

Acquisition-Related Contingent Consideration

The Company has recognized contingent consideration related to the Flexion Acquisition and the MyoScience Acquisition in the amount of ~~$35.2~~$21.5 million and ~~$57.6~~$28.1 million as of June 30, ~~2022~~2023 and December 31, ~~2021,~~2022, respectively. For more information, see Note 14, Acquisition-Related (Gains) Charges, Restructuring Charges and Other.

The Company’s contingent consideration obligations are recorded at their estimated fair values and are revalued each reporting period if and until the related contingencies are resolved. The Company has measured the fair value of its contingent consideration using a probability-weighted discounted cash flow approach that is based on unobservable inputs and a Monte Carlo simulation. These inputs include, as applicable, estimated probabilities and the timing of achieving specified commercial and regulatory milestones, estimated forecasts of revenue and costs and the discount rates used to calculate the present value of estimated future payments. Significant changes may increase or decrease the probabilities of achieving the related commercial and regulatory events, shorten or lengthen the time required to achieve such events, or increase or decrease estimated forecasts.

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In November 2021, the Company completed the Flexion Acquisition, which provided for contingent consideration related to ~~CVRs~~contingent value rights that were issued to Flexion shareholders and certain equity award holders which could aggregate up to a total of ~~$425.5~~$372.3 million if certain regulatory and commercial milestones are met. The aggregate amount was initially $425.5 million prior to the Company’s September 2022 decision to formally discontinue further development of Flexion’s product candidate, PCRX-301. The Company’s obligation to make milestone payments is limited to those milestones achieved through December 31, 2030, and are to be paid within 60 days of the end of the fiscal quarter of achievement. As part of the purchase price consideration related to the Flexion Acquisition, the Company recorded contingent consideration of $45.2 million, which represented the Company’s potential achievement of meeting the regulatory and commercial milestones. For the period from the date of the Flexion Acquisition through December 31, 2021, the Company recorded an additional $1.2 million liability. During the three and six months ended June 30, 2023, the Company recorded gains of $18.3 million and $6.6 million, respectively, due to adjustments to long-term forecasts which reduced the probability of meeting the sales-based contingent consideration milestones by December 31, 2030, the expiration date for achieving the milestones. The gains recognized during the six months ended June 30, 2023 were partially offset by a decrease in the assumed discount rate that is utilized in calculating the liability’s present value, based on a significant improvement in the Company’s incremental borrowing rate resulting from the TLA Credit Agreement entered into in March 2023. During the three and six months ended June 30, 2022,, the Company recorded gains of $12.5 million and $13.3 million, respectively, primarily due to adjustments to near-term forecasts for the earnout period of the contingent consideration. These adjustments were recorded as acquisition-related ~~gains~~charges (gains) in the condensed consolidated statements of operations. At June 30, ~~2022,~~2023, the weighted average discount rate was ~~13.5%~~10.2% and the ~~weighted average~~ probability of ~~success~~payment for the achievement of the remaining regulatory ~~milestones~~milestone by the expiration date was ~~11.1%~~12.5%. As of June 30, ~~2022~~2023 and December 31, ~~2021,~~2022, a contingent consideration liability related to the Flexion Acquisition was recognized in the amount of ~~$33.1~~$21.5 million and ~~$46.4~~$28.1 million, respectively.

In April 2019, the Company completed the MyoScience Acquisition pursuant to the terms of an Agreement and Plan of Merger, which provided for contingent milestone payments of up to an aggregate of $100.0 million upon the achievement of certain regulatory and commercial milestones. The Company’s obligation to make milestone payments is limited to those milestones achieved through December 31, 2023, and are to be paid within 60 days of the end of the fiscal quarter of achievement. As of June 30, ~~2022,~~2023, the maximum potential remaining milestone payments to be paid are $43.0 million. ~~The Company recognized~~At June 30, 2023, the probability of success for the regulatory milestone that has not yet been met was assessed as zero. As of June 30, 2023 and December 31, 2022, a contingent consideration ~~gains of $8.8 million and $9.0 million during~~liability related to the MyoScience Acquisition has been assessed as zero. During the three and six months ended June 30, 2022, the Company recognized contingent consideration gains of $8.8 million and $9.0 million, respectively, due to the reduced probability of meeting the contingent consideration milestones by December 31, 2023, the expiration date for achieving the milestones. ~~The Company recognized a $0.1 million contingent consideration charge and a $1.0 million gain during the three and~~ ~~six months ended June 30,2021, respectively~~.

At June 30, 2022, the weighted average discount rate was 12.5% and the probability of success for the regulatory milestone that has not yet been met was reduced to 0. As of June 30, 2022 and December 31, 2021, a contingent consideration liability related to the MyoScience Acquisition has been recognized in the amounts of $2.1 million and $11.2 million, respectively.

The following table includes the key assumptions used in the valuation of the Company’s contingent consideration:

Assumption

Flexion Ranges

Utilized as of

June 30, ~~2022~~

~~MyoScience Ranges~~

~~Utilized as of~~

~~June 30, 2022~~2023

Discount rates

~~12.64%~~9.4% to ~~14.37%~~

~~11.69% to 13.34%~~11.0%

Probabilities of payment for regulatory milestones

5%0% to ~~15%~~

0%12.5%

Projected years of payment for regulatory and commercial milestones

~~2027 to~~ 2030

~~2023~~

The change in the Company’s contingent consideration recorded at fair value using Level 3 measurements is as follows (in thousands):


	Contingent Consideration Fair Value
Balance at December 31, 2021	$	57,598
Fair value adjustments and accretion	(29,476)
Balance at December 31, 2022	28,122
Fair value adjustments and accretion	~~(22,351)~~(6,640)


Balance at June 30, ~~2022~~2023	$	~~35,247~~21,482

~~Pacira BioSciences, Inc. | Q2 2022 Form 10-Q | Page 23~~

~~Table of Contents~~

Available-for-Sale Investments

Short-term investments consist of asset-backed securities collateralized by credit card receivables, investment grade commercial paper and corporate, federal agency and government bonds with maturities greater than three months, but less than one year. Noncurrent investments consist of federal agency bonds and government bonds with maturities greater than one year but less than three years. Net unrealized gains and losses (excluding credit losses, if any) from the Company’s short-term investments are reported in other comprehensive ~~income (loss).~~income. At June 30, ~~2022~~2023 and December 31, ~~2021,~~2022, all of the Company’s short-term and noncurrent investments are classified as available-for-sale investments and are determined to be Level 2 instruments,

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which are measured at fair value using standard industry models with observable inputs. The fair value of the commercial paper is measured based on a standard industry model that uses the three-month U.S. Treasury bill rate as an observable input. The fair value of the asset-backed securities and corporate bonds is principally measured or corroborated by trade data for identical issues in which related trading activity is not sufficiently frequent to be considered a Level 1 input or that of comparable securities. At the time of purchase, all ~~short-term~~available-for-sale investments had an “A” or better rating by Standard & Poor’s.

The following summarizes the Company’s short-term and noncurrent available-for-sale investments at June 30, ~~2022~~2023 and December 31, ~~2021~~2022 (in thousands):


June 30, 2022 Investments		Cost		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value (Level 2)

June 30, 2023 Investments										June 30, 2023 Investments	Cost		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value (Level 2)
Current:										Current:
Asset-backed securities	Asset-backed securities	$	30,906	$	—	$	(239)	$	30,667	Asset-backed securities	$	5,972	$	—	$	(16)	$	5,956
Commercial paper	Commercial paper	138,705		—		(796)		137,909		Commercial paper	49,007		—		(99)		48,908
Corporate bonds		6,288		—		(31)		6,257
U.S. Government bonds		19,531		—		(32)		19,499

U.S. federal agency bonds										U.S. federal agency bonds	64,789		—		(314)		64,475
U.S. government bonds										U.S. government bonds	14,697		—		(80)		14,617

Total	Total	$	195,430	$	—	$	(1,098)	$	194,332	Total	$	134,465	$	—	$	(509)	$	133,956


December 31, 2021 Investments		Cost		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value (Level 2)

December 31, 2022 Investments										December 31, 2022 Investments	Cost		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value (Level 2)
Current:										Current:
Asset-backed securities	Asset-backed securities	$	3,182	$	—	$	—	$	3,182	Asset-backed securities	$	6,836	$	—	$	(3)	$	6,833
Commercial paper	Commercial paper	57,533		80		(2)		57,611		Commercial paper	134,423		23		(386)		134,060
Corporate bonds		9,936		102		—		10,038

Total		$	70,651	$	182	$	(2)	$	70,831
U.S. federal agency bonds										U.S. federal agency bonds	41,971		—		(337)		41,634
U.S. government bonds										U.S. government bonds	2,003		—		(18)		1,985
Subtotal										Subtotal	$	185,233	$	23	$	(744)	$	184,512
Noncurrent:										Noncurrent:

U.S. federal agency bonds										U.S. federal agency bonds	22,783		2		(66)		22,719
U.S. government bonds										U.S. government bonds	14,499		—		(9)		14,490
Subtotal										Subtotal	37,282		2		(75)		37,209
Total										Total	$	222,515	$	25	$	(819)	$	221,721

At June 30, ~~2022,~~2023, there were no investments available for sale that were materially less than their amortized cost.

The Company elects to recognize its interest receivable separate from its available-for-sale investments. At June 30, ~~2022~~2023 and December 31, ~~2021,~~2022, the interest receivable from its available-for-sale investments recognized in prepaid expenses and other current assets was ~~$0.2~~$0.9 million and ~~$0.1~~$0.8 million, respectively.

Credit Risk

Financial instruments that potentially subject the Company to concentrations of credit risk consist primarily of cash and cash equivalents, short-term and long-term available-for-sale investments and accounts receivable. The Company maintains its cash and cash equivalents with high-credit quality financial institutions. Such amounts may exceed federally-insured limits.

As of June 30, 2023, three wholesalers each accounted for over 10% of the Company’s accounts receivable, at 36%, 21% and 15%. At December 31, 2022, 3three wholesalers each accounted for over 10% of the Company’s accounts receivable, at 34%, ~~17%~~19% and ~~17%. At December 31, 2021, 4 wholesalers each accounted for over 10% of the Company’s accounts receivable, at 30%, 20%, 17% and 11%~~18%. For additional information regarding the Company’s wholesalers, see Note 2, Summary of Significant Accounting Policies. EXPAREL and ZILRETTA revenues are primarily derived from major wholesalers and specialty distributors that generally have significant cash resources. The Company performs ongoing credit evaluations of its customers as warranted and generally does not require collateral. Allowances for credit losses on the Company’s accounts receivable are maintained based on historical payment patterns, current and estimated future economic conditions, aging of accounts receivable and its write-off history. As of June 30, ~~2022~~2023 and December 31, ~~2021,~~2022, the Company did not deem any allowances for credit losses on its accounts receivable necessary.

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 2422

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NOTE ~~11—~~10—STOCKHOLDERS’ EQUITY

Accumulated Other Comprehensive ~~(Loss) Income~~Loss

The following tables illustrate the changes in the balances of the Company’s accumulated other comprehensive ~~(loss) income~~loss for the periods presented (in thousands):

Net Unrealized (Loss) Gain From Available
For Sale Investments Unrealized Foreign Currency Translation Accumulated Other Comprehensive (Loss) Income
Balance at December 31, 2021 $ 139 $ 28 $ 167
Net unrealized loss on investments, net of tax (893) — (893)
Foreign currency translation adjustments — 121 121
Balance at June 30, 2022 $ (754) $ 149 $ (605)


	Net Unrealized Gain (Loss) From Available-For-Sale Investments		Unrealized Foreign Currency Translation		Accumulated Other Comprehensive Loss
Balance at December 31, 2022	$	(523)	$	143	$	(380)
Net unrealized gain on investments, net of tax (1)	216		—		216
Foreign currency translation adjustments	—		(9)		(9)

Balance at June 30, 2023	$	(307)	$	134	$	(173)


		Net Unrealized (Loss) Gain From Available For Sale Investments		Unrealized Foreign Currency Translation		Accumulated Other Comprehensive (Loss) Income			Net Unrealized (Loss) Gain From Available-For-Sale Investments		Unrealized Foreign Currency Translation		Accumulated Other Comprehensive (Loss) Income
Balance at December 31, 2020		$	319	$	(1)	$	318
Balance at December 31, 2021								Balance at December 31, 2021	$	139	$	28	$	167
Net unrealized loss on investments, net of tax(1)	Net unrealized loss on investments, net of tax(1)	(138)		—		(138)		Net unrealized loss on investments, net of tax(1)	(893)		—		(893)
Foreign currency translation adjustments	Foreign currency translation adjustments	—		1		1		Foreign currency translation adjustments	—		121		121
Balance at June 30, 2021		$	181	$	—	$	181
Balance at June 30, 2022								Balance at June 30, 2022	$	(754)	$	149	$	(605)

(1) Net of a $0.2 million tax expense and $0.3 million tax benefit for the six months ended June 30, 2023 and 2022, respectively.

NOTE ~~12—~~11—STOCK PLANS

Stock Incentive Plans

The Company’s Amended and Restated 2011 Stock Incentive Plan, or 2011 Plan, was originally adopted by its board of directors and approved by its stockholders in June 2011 and was amended and restated in June 2014, June 2016, June 2019, June 2021 and June 2023. In June 2023, the Company’s stockholders approved the amendment and restatement which increased the number of shares of common stock authorized for issuance as equity awards under the 2011 Plan by 3,300,000 shares. The 2011 Plan allows the granting of incentive stock options, non-statutory stock options, restricted stock units and other stock-based awards.

Stock-Based Compensation

The Company recognized stock-based compensation expense in the periods presented as follows (in thousands):


		Three Months Ended June 30,				Six Months Ended June 30,					Three Months Ended June 30,				Six Months Ended June 30,
		2022		2021		2022		2021			2023		2022		2023		2022
Cost of goods sold	Cost of goods sold	$	1,478	$	1,465	$	2,830	$	2,917	Cost of goods sold	$	1,436	$	1,478	$	3,160	$	2,830
Research and development	Research and development	1,520		1,329		2,978		2,435		Research and development	1,722		1,520		3,597		2,978
Selling, general and administrative	Selling, general and administrative	8,546		7,667		16,925		15,219		Selling, general and administrative	7,797		8,546		16,188		16,925
Total	Total	$	11,544	$	10,461	$	22,733	$	20,571	Total	$	10,955	$	11,544	$	22,945	$	22,733

Stock-based compensation from:	Stock-based compensation from:									Stock-based compensation from:
Stock options	Stock options	$	6,542	$	6,552	$	13,327	$	13,048	Stock options	$	5,742	$	6,542	$	12,206	$	13,327
Restricted stock units	Restricted stock units	4,717		3,646		8,830		7,038		Restricted stock units	4,969		4,717		10,219		8,830
Employee stock purchase plan	Employee stock purchase plan	285		263		576		485		Employee stock purchase plan	244		285		520		576
Total	Total	$	11,544	$	10,461	$	22,733	$	20,571	Total	$	10,955	$	11,544	$	22,945	$	22,733

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 2523

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Equity Awards

The following tables contain information about the Company’s stock option and restricted stock unit, or RSU, activity for the six months ended June 30, ~~2022:~~2023:


Stock Options	Stock Options	Number of Options	Weighted Average Exercise Price (Per Share)		Stock Options	Number of Stock Options	Weighted Average Exercise Price (Per Share)
Outstanding at December 31, 2021		6,050,540	$	49.32
Outstanding at December 31, 2022					Outstanding at December 31, 2022	6,272,994	$	52.38
Granted	Granted	1,010,780	60.22		Granted	1,426,343	39.15
Exercised	Exercised	(630,413)	34.80		Exercised	(61,896)	30.91
Forfeited	Forfeited	(54,215)	52.41		Forfeited	(106,927)	57.38
Expired	Expired	(13,054)	85.48		Expired	(88,438)	55.06
Outstanding at June 30, 2022		6,363,638	52.39
Outstanding at June 30, 2023					Outstanding at June 30, 2023	7,442,076	49.91


Restricted Stock Units	Restricted Stock Units	Number of Units	Weighted Average Grant Date Fair Value (Per Share)		Restricted Stock Units	Number of Restricted Stock Units	Weighted Average Grant Date Fair Value (Per Share)
Unvested at December 31, 2021		955,277	$	52.85
Unvested at December 31, 2022					Unvested at December 31, 2022	1,149,462	$	57.26
Granted	Granted	568,049	60.63		Granted	759,762	39.24
Vested	Vested	(298,607)	49.65		Vested	(368,641)	54.96
Forfeited	Forfeited	(44,929)	54.16		Forfeited	(95,349)	58.56
Unvested at June 30, 2022		1,179,790	57.36
Unvested at June 30, 2023					Unvested at June 30, 2023	1,445,234	48.27

The weighted average fair value of stock options granted during the six months ended June 30, ~~2022~~2023 was~~$25.69~~ $16.22 per share. The fair values of stock options granted were estimated using the Black-Scholes option valuation model with the following weighted average assumptions:


Black-Scholes Weighted Average Assumption						Six Months Ended June 30, ~~2022~~2023
Expected dividend yield						None
Risk-free interest rate						~~2.83%~~4.00%
Expected volatility						~~45.15%~~41.32%
Expected term of options						~~4.92~~4.86 years

Employee Stock Purchase Plan

~~In June 2022, the~~The Company’s ~~stockholders approved the~~ Amended and Restated 2014 Employee Stock Purchase Plan, or ~~ESPP. The ESPP was amended to increase the number of shares of common stock that may be sold under the ESPP by an additional 500,000 shares.~~

~~The~~ ESPP, features 2two six-month offering periods per year, running from January 1 to June 30 and July 1 to December 31. Under the ESPP, employees may elect to contribute after-tax earnings to purchase shares at 85% of the closing fair market value of the Company’s common stock on either the offering date or the purchase date, whichever is ~~less.~~lesser. During the six months ended June 30, ~~2022, 36,729~~2023, 50,634 shares were purchased and issued through the ESPP.

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 2624

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NOTE ~~13—~~12—NET INCOME ~~(LOSS)~~ PER SHARE

Basic net income ~~(loss)~~ per common share is calculated by dividing the net income ~~(loss)~~ attributable to common shares by the weighted average number of common shares outstanding during the period. Diluted net income ~~(loss)~~ per common share is calculated by dividing the net income ~~(loss)~~ attributable to common shares by the weighted average number of common shares outstanding plus dilutive potential common shares outstanding during the period.

~~ASU 2020-06 was adopted on January 1, 2022~~Potential common shares include the shares of common stock issuable upon the exercise of outstanding stock options, the vesting of RSUs and ~~requires~~ the ~~Company to use~~purchase of shares from the ~~if-converted method to calculate~~ESPP (using the ~~number of potentially dilutive~~treasury stock method), if applicable. Potential common shares ~~for~~associated with convertible ~~debt. Under~~notes are treated under the if-converted method, adjustments are made to the diluted net income ~~(loss)~~ per common share calculation as if the Company had converted the convertible debt on the first day of each period presented. Adjustments to the numerator are made to add back the interest expense associated with the convertible debt on a post-tax basis. Adjustments to the denominator reflect the number of shares assumed to be convertible at the beginning of the period. ~~For additional information regarding ASU 2020-06, see Note 2, Summary of Significant Accounting Policies. Prior to January 1, 2022, the Company used the treasury stock method to calculate dilutive shares on its convertible debt.~~

Potential common shares include the shares of common stock issuable upon the exercise of outstanding stock options, the vesting of RSUs and the purchase of shares from the ESPP (using the treasury stock method), if applicable.

Potential common shares are excluded from the diluted net income ~~(loss)~~ per common share computation to the extent they would be antidilutive.

The following table sets forth the computation of basic and diluted net income per common share for the three and six months ended June 30, ~~2022~~2023 and ~~2021~~2022 (in thousands, except per share amounts):

Three Months Ended
June 30, Six Months Ended
June 30,
2022 2021 2022 2021
Numerator:
   Net income—basic $ 19,876 $ 19,081 $ 26,704 $ 29,450
ASU 2020-06 convertible notes if-converted method adjustment 1,039 — 2,078 —
   Adjusted net income—diluted 20,915 19,081 28,782 29,450
Denominator:
   Weighted average common shares outstanding—basic 45,501 44,145 45,185 43,989
Computation of diluted securities:
ASU 2020-06 convertible notes if-converted method adjustment 5,607 — 5,607 —
   Dilutive effect of stock options 1,016 1,062 1,106 1,284
   Dilutive effect of RSUs 347 381 360 426
Dilutive effect of conversion premium on the 2022 Notes — — — 76
Dilutive effect of ESPP purchase options 7 4 4 4
   Weighted average common shares outstanding—diluted 52,478 45,592 52,262 45,779
Net income per share:
   Basic net income per common share $ 0.44 $ 0.43 $ 0.59 $ 0.67
   Diluted net income per common share $ 0.40 $ 0.42 $ 0.55 $ 0.64

~~Pacira BioSciences, Inc. | Q2 2022 Form 10-Q | Page 27~~

~~Table of Contents~~


	Three Months Ended June 30,				Six Months Ended June 30,
	2023		2022		2023		2022
Numerator:
Net income—basic	$	25,763	$	19,876	$	6,227	$	26,704
ASU 2020-06 convertible notes if-converted method adjustment	1,029		1,039		—		2,078

Adjusted net income—diluted	$	26,792	$	20,915	$	6,227	$	28,782





Denominator:
Weighted average common shares outstanding—basic	46,088		45,501		46,019		45,185
Computation of diluted securities:
ASU 2020-06 convertible notes if-converted method adjustment	5,607		5,607		—		5,607
Dilutive effect of stock options	108		1,016		92		1,106
Dilutive effect of RSUs	244		347		170		360
Dilutive effect of ESPP purchase options	7		7		4		4
Weighted average common shares outstanding—diluted	52,054		52,478		46,285		52,262
Net income per share:
Basic net income per common share	$	0.56	$	0.44	$	0.14	$	0.59
Diluted net income per common share	$	0.51	$	0.40	$	0.13	$	0.55

The following table summarizes the outstanding stock options, RSUs and convertible senior notes that were excluded from the diluted net income per common share calculation because the effects of including these potential shares were antidilutive in the periods presented (in thousands):


		Three Months Ended June 30,		Six Months Ended June 30,			Three Months Ended June 30,		Six Months Ended June 30,
		2022	2021	2022	2021		2023	2022	2023	2022
Weighted average number of stock options	Weighted average number of stock options	1,948	2,088	1,855	1,489	Weighted average number of stock options	5,404	1,948	5,403	1,855
Convertible senior notes	Convertible senior notes	—	—	1,196	—	Convertible senior notes	—	—	5,607	1,196
Weighted average number of RSUs	Weighted average number of RSUs	31	26	24	14	Weighted average number of RSUs	701	31	759	24

Total	Total	1,979	2,114	3,075	1,503	Total	6,105	1,979	11,769	3,075

For the six months ended June 30, 2023, the antidilutive impact associated with the convertible senior notes would have included an interest expense add-back to net income of $2.1 million.

Pacira BioSciences, Inc. | Q2 2023 Form 10-Q | Page 25

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NOTE ~~14—~~13—INCOME TAXES

Income before income taxes and income tax expense isare as follows (dollar amounts in thousands):


		Three Months Ended June 30,						Six Months Ended June 30,							Three Months Ended June 30,						Six Months Ended June 30,
		2022			2021			2022			2021				2023			2022			2023			2022
Income (loss) before income taxes:	Income (loss) before income taxes:													Income (loss) before income taxes:
Domestic	Domestic	$	23,798		$	25,863		$	30,380		$	41,795		Domestic	$	40,189		$	23,798		$	12,416		$	30,380
Foreign	Foreign	(1,791)			(215)			(1,079)			(3,424)			Foreign	(2,335)			(1,791)			(1,036)			(1,079)
Total income before income taxes	Total income before income taxes	$	22,007		$	25,648		$	29,301		$	38,371		Total income before income taxes	$	37,854		$	22,007		$	11,380		$	29,301

Income tax expense	Income tax expense	$	2,131		$	6,567		$	2,597		$	8,921		Income tax expense	$	12,091		$	2,131		$	5,153		$	2,597
Effective tax rate	Effective tax rate	10		%	26		%	9		%	23		%	Effective tax rate	32		%	10		%	45		%	9		%

The Company’s income tax expense represents the estimated annual effective tax rate applied to the year-to-date domestic operating ~~results~~results adjusted for certain discrete tax items.

The Company’s effective tax rates for the three and six months ended June 30, 2023 includes costs related to non-deductible stock-based compensation, a valuation allowance recorded against non-U.S. results and non-deductible executive compensation. The Company’s effective tax rate for the three and six months ended June 30, 2022 ~~include~~includes benefits related to stock-based compensation, a first quarter Skyepharma milestone payment and a fair value adjustment for Flexion contingent consideration, partially offset by ~~non-deductible~~nondeductible executive compensation costs and a valuation allowance against non-U.S. results. The Company’s effective tax rates for the three and six months ended June 30, 2021 include benefits related to stock-based compensation offset by non-deductible executive compensation costs and valuation allowances recorded against deductible capital losses and non-U.S. results.

NOTE ~~15—ACQUISITION–RELATED~~14—ACQUISITION-RELATED (GAINS) CHARGES, ~~PRODUCT DISCONTINUATION~~RESTRUCTURING CHARGES AND OTHER

Acquisition-related (gains) charges, ~~product discontinuation~~restructuring charges and other for the three and six months ended June 30, ~~2022~~2023 and ~~2021~~2022 summarized below (in thousands):

Three Months Ended
June 30, Six Months Ended
June 30,
2022 2021 2022 2021
Severance-related expenses $ 950 $ — $ 4,065 $ —
Acquisition-related fees 2,168 7 4,013 7
Other acquisition expenses 104 — 552 —
Total acquisition-related charges 3,222 7 8,630 7
Flexion contingent consideration (12,523) — (13,317) —
MyoScience contingent consideration (8,757) 139 (9,034) (988)
Nuance Biotech Co. Ltd. agreement dissolution costs — — — 3,000
Total acquisition-related (gains) charges, product discontinuation and other $ (18,058) $ 146 $ (13,721) $ 2,019

~~Pacira BioSciences, Inc. | Q2 2022 Form 10-Q | Page 28~~

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	Three Months Ended June 30,				Six Months Ended June 30,
	2023		2022		2023		2022
Severance-related expenses	$	—	$	950	$	—	$	4,065
Acquisition-related fees	709		2,168		1,198		4,013
Other acquisition expenses	—		104		—		552
Total acquisition-related charges	709		3,222		1,198		8,630
Flexion contingent consideration	(18,258)		(12,523)		(6,640)		(13,317)
MyoScience contingent consideration	—		(8,757)		—		(9,034)

Restructuring charges	936		—		936		—
Total acquisition-related (gains) charges, restructuring charges and other	$	(16,613)	$	(18,058)	$	(4,506)	$	(13,721)

Flexion Acquisition

The Company recognized acquisition-related costs of $0.7 million and $1.2 million during the three and six months endedJune 30, 2023, respectively, primarily related to the remaining Flexion leases. The Company recognized acquisition-related costs of $3.2 million and $8.6 million during the three and six months ended June 30, 2022, respectively,, primarily ~~for~~related to severance, legal fees, third-party services and other one-time ~~charges related to the Flexion Acquisition. See Note~~ 4, ~~Flexion Acquisition, for more information.~~charges.

~~On November 19, 2021, as part of the purchase price~~The Company recognized $18.3 million and $6.6 million contingent consideration related to the Flexion Acquisition, the Company recorded contingent consideration of $45.2 million, which represents the Company’s potential achievement of meeting regulatory and sales-based milestones. Duringgains during the three and six months ended June 30, ~~2022, the~~2023, respectively. The Company ~~recorded~~recognized $12.5 million and $13.3 million ~~gains, respectively, due to a decrease to the fair value~~ of ~~its~~ contingent consideration ~~which was included in acquisition-related (gains) charges in~~gains during the ~~condensed consolidated statements of operations.~~three and six months endedJune 30, 2022, respectively. See Note 109, Financial Instruments, for information regarding the method, key assumptions used in the fair value measurements of contingent consideration and more information regarding the changes in fair value.

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MyoScience Acquisition

The Company recognized $8.8 million and $9.0 million of contingent consideration gains during the three and six months ended June 30, ~~2022, respectively~~. ~~The Company recognized a $0.1 million contingent consideration charge and a $1.0 million gain during the three and~~ ~~six months ended June 30,~~ ~~2021, respectively~~.2022, respectively. See Note 109, Financial Instruments, for information regarding the method, key assumptions used in the fair value measurements of contingent consideration and more information regarding the changes in fair value.

~~Nuance Biotech Co. Ltd.~~Restructuring Charges

In ~~June 2018,~~June 2023, the Company implemented a restructuring plan in an effort to improve its operational efficiencies. The restructuring charges are predominantly related to one-time employee termination benefits through a reduction of headcount, such as severance and related costs. During the ~~Company entered an agreement with Nuance Biotech Co. Ltd., or Nuance, a China-based specialty pharmaceutical company, to advance the development~~three and commercialization of EXPAREL in China. Under the terms of the agreement, the Company had granted Nuance the exclusive rights to develop and commercialize EXPAREL. In April 2021, the Company and Nuance agreed to a mutual termination of the agreement due to the lack of a viable regulatory pathway that adequately safeguards the Company’s intellectual property against the risk of a generic product. Dissolution costs of $3.0 million were included in other operating expenses in the condensed consolidated statements of operations for the six months ended June 30, 2023, t~~2021.~~he Company recognized $0.9 million of restructuring charges, of which $0.4 million was paid. The remaining $0.5 million is expected to be paid in the third quarter of 2023.

NOTE ~~16—~~15—COMMITMENTS AND CONTINGENCIES

From time to time, the Company has been and may again become involved in legal proceedings arising in the ordinary course of its business, including those related to patents, product liability and government investigations. Except as described below, the Company is not presently a party to any legal proceedings that it believes to be material, and is not aware of any pending or threatened litigation against the Company which it believes could have a material adverse effect on its business, operating results, financial condition or cash flows.

MyoScience Milestone Litigation

In August 2020, the Company and its subsidiary, Pacira CryoTech, Inc. (“Pacira CryoTech”), filed a lawsuit in the Court of Chancery of the State of Delaware against Fortis Advisors LLC (“Fortis”), solely in its capacity as representative for the former securityholders of MyoScience, and certain other defendants, seeking declaratory judgment with respect to certain terms of the merger agreement for the MyoScience Acquisition (the ~~“Merger~~“MyoScience Merger Agreement”), specifically related to the achievement of certain milestone payments under the MyoScience Merger Agreement. In addition, the Company and Pacira CryoTech sought general, special and compensatory damages against the other defendants related to breach of fiduciary duties in connection with the purported achievement of milestone payments under the MyoScience Merger Agreement, and breach of the MyoScience Merger Agreement and certain other agreements with the defendants. In October 2020, Fortis filed an answer and counterclaim against the Company and Pacira CryoTech seeking to recover certain milestone payments under the MyoScience Merger Agreement. The total remaining value of these milestones is $30.0 million, plus attorneys’ fees. The Company believes that the counterclaim from Fortis is without merit and intends to vigorously defend against all claims. A trial is expected to commence in the second half of 2023. The Company is unable to predict the outcome of this action at this time.

eVenus Pharmaceutical Laboratories Litigations

In October 2021, the Company received a Notice Letter advising that eVenus Pharmaceutical Laboratories, Inc., or eVenus, of Princeton, New Jersey, submitted to the FDA an Abbreviated New Drug Application, ~~(ANDA)~~or ANDA with a Paragraph IV certification seeking authorization for the manufacturing and marketing of a generic version of EXPAREL (266 mg/20 mL) in the U.S. prior to the expiration of U.S. Patent No. 11,033,495 (the ’495 patent).

~~Pacira BioSciences, Inc. | Q2 2022 Form 10-Q | Page 29~~

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In November 2021, the Company filed a patent infringement suit against eVenus and its parent company in the U.S. District Court for the District of New Jersey (21-cv-19829) asserting infringement of the ’495 patent. This triggered an automatic 30-month stay of final approval of the eVenus ANDA. On January 6, 2022, eVenus filed an Answer with counterclaims to the Complaint, alleging the ’495 patent is invalid and/or not infringed through the manufacture, sale, or offer for sale of the product described in product described in eVenus’s ANDA submission.

In December 2021, the Company received a second Notice Letter advising that eVenus submitted to the FDA an amendment to its ANDA with a Paragraph IV Certification seeking authorization for the manufacturing and marketing of a generic version of EXPAREL (133 mg/10 mL) in the U.S. prior to the expiration of the ’495 patent. In the Notice Letter, eVenus also advised that it submitted a Paragraph IV Certification to the FDA seeking authorization for the manufacturing and marketing of a generic version of EXPAREL (266 mg/20 mL and 133 mg/10 mL) in the U.S. prior to the expiration of U.S. Patent No. 11,179,336 (the ’336 patent). eVenus further alleges in the Notice Letter that both the ’495 patent and the ~~’366~~’336 patent are invalid and/or not infringed.

In February 2022, the Company filed a second patent infringement suit against eVenus and its parent company in the U.S. District Court for the District of New Jersey (22-cv-00718) asserting that the 133 mg/10 mL ANDA product will infringe the ’495 and ’336 patents and that the 266 mg/20 mL ANDA product will infringe the ’336 patent. This filing triggered a second

Pacira BioSciences, Inc. | Q2 2023 Form 10-Q | Page 27

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automatic 30-month stay of final approval for the 133 mg/10 mL ANDA product. The first and second patent infringement suits were consolidated.

In February 2023, eVenus filed its first amended answer to the first amended complaint, alleging patent invalidity, non-infringement and inequitable conduct. The Company has denied the allegations in eVenus’s first amended answer.

In April 2023, the Company filed a third patent infringement suit against eVenus, its parent company, and Fresenius Kabi USA, LLC, in the U.S. District Court for the District of New Jersey (23-cv-2367) asserting that the 133 mg/10 mL and 266 mg/20 mL ANDA products will infringe U.S. Patent No. 11,426,348 (the ’348 patent). In July 2023, eVenus filed its answer with claims for declaratory judgment, alleging patent invalidity, non-infringement and inequitable conduct with respect to the ’348 patent as well as the Company’s other patents, U.S. Patent Nos. 11,278,494; 11,304,904; 11,311,486; 11,357,727 and 11,452,691.

These litigations are in their ~~infancy,~~early stages, and the Company is unable to predict ~~the~~their outcome ~~of this action~~ at this time.

Research Development Foundation

Pursuant to an agreement with the Research Development Foundation, or RDF, the Company was required to pay RDF a low single-digit royalty on the collection of revenues from certain products, for as long as certain patents assigned to the Company under the agreement remain valid. RDF has the right to terminate the agreement for an uncured material breach by the Company, in connection with its bankruptcy or insolvency or if it directly or indirectly opposes or disputes the validity of the assigned patent rights. The Company’s ~~U.S. Patent No. 11,033,495 was~~’495 patent issued on June 15, 2021. Thereafter, RDF asserted that the issuance of that patent extends the Company’s royalty obligations under the agreement until 2041. The Company believes that the royalty period under the agreement ~~was set to end~~ended on December 24, 2021 with the expiration of its U.S. Patent No. 9,585,838. Because of the disagreement over the interpretation of the agreement, in December 2021, the Company filed a declaratory judgment lawsuit in the U.S. District Court for the District of Nevada (21-cv-02241). The lawsuit seeks a declaration from the court that the Company owes no royalties to RDF with respect to its EXPAREL product after December 24, 2021. During the pendency of the lawsuit, the Company will continue to pay royalties to RDF under protest, however, the Company is unable to predict the outcome of this action at this time.

Other Commitments and Contingencies

Pediatric Trial Commitments

The FDA, as a condition of EXPAREL approval, has required the Company to study EXPAREL ~~in pediatric patients, as well as the administration of EXPAREL~~for infiltration and as a ~~nerve~~brachial plexus block in the pediatric setting. The Company was granted ~~a deferral~~deferrals for the required pediatric trials until after the indications were approved in adults. Similarly, in Europe, the Company agreed with the European Medicines Agency, or EMA, on a Pediatric Investigation Plan as a prerequisite for submitting a Marketing Authorization Application (MAA) in the E.U. Despite the U.K.’s withdrawal from the E.U., the agreed pediatric plan is applicable in the U.K.

In December 2019, the Company announced positive results for its extended pharmacokinetic and safety study (“PLAY”) for local analgesia in children aged six to 17 undergoing cardiovascular or spine surgeries. Those positive results were the basis for the submission of a supplemental New Drug Application, or sNDA, in the U.S. ~~and Type II variations in the E.U. and U.K. to expand the EXPAREL label~~ to include use in patients six years of age and older for single-dose infiltration to produce postsurgical local analgesia. In March 2021, the Company announced that the FDA approved the ~~submission of the~~ sNDA in the U.S. In the E.U. and U.K., the Company also submitted the results of the PLAY study as Type II variations in the E.U. and U.K. to include the use of EXPAREL in children aged six years or older as a field block for treatment of somatic post-operative pain for small- to medium-sized wounds. The EMA and the Medicines and Healthcare Products Regulatory Agency, or MHRA, ~~are still reviewing~~in the ~~Type II variations.~~

U.K. both approved the variations in their respective regions in November 2022. The Company is working with the FDA, ~~MAA~~EMA and MHRA to finalize the regulatory pathway for its remaining pediatric commitments.

~~Hong Kong Pharma Tainuo Ltd.~~Contingent Milestone Payments

Refer to Note 9, Financial Instruments, for information on potential contingent milestone payments related to the Flexion Acquisition and MyoScience Acquisition.

PCRX-201

PCRX-201, a novel, intra-articular gene therapy product candidate that produces the anti-inflammatory protein interleukin-1 receptor antagonist (IL-1Ra) treating OA pain in the knee, was added to the Company’s portfolio as part of the Flexion Acquisition in November 2021. Prior to the Flexion Acquisition, in ~~March 2020,~~February 2017, Flexion entered into an ~~exclusive license~~ agreement with ~~Hong Kong Tainuo Pharma Ltd., or HK Tainuo, and Jiangsu Tainuo Pharmaceutical Co. Ltd., or Jiangsu Tainuo, a subsidiary of China~~GQ Bio Therapeutics GmbH (formerly named GeneQuine Biotherapeutics GmbH) to acquire the global rights to

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 3028

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~~Shijiazhuang Pharmaceutical Co, Ltd., for the development and commercialization of ZILRETTA in Greater China (consisting of mainland China, Hong Kong, Macau and Taiwan). Under the terms~~PCRX-201, a gene therapy product candidate. As part of the agreement, HK Tainuo paid Flexion an upfront payment of $10.0 million during the year ended December 31, 2020 which was recorded in other liabilities as of June 30, 2022 and December 31, 2021. The Company was also eligible to receive up to ~~$32.5~~an aggregate of $56.0 million of payments could become due upon the achievement of certain development and regulatory milestones, including up to $4.5 million through initiation of a Phase 2 proof of concept clinical trial and, following successful proof of concept, up to an additional $51.5 million in ~~aggregate~~ development and global regulatory ~~and commercial sales~~approval milestone payments under the exclusive license agreement. HK Tainuo was responsible for the clinical development, product registration and commercialization of ZILRETTA in Greater China. The Company was solely responsible for the manufacture and supply of ZILRETTA to HK Tainuo for all clinical and commercial activities. The terms related to product manufacturing and supply, including pricing and minimum purchase requirements agreed to in the license agreement, were to be covered by a separate supply agreement, which had not yet been finalized as of June 30, 2022. Unless terminated earlier in accordance with its terms, the license agreement was scheduled to continue in effect in perpetuity or as long as HK Tainuo or Jiangsu Tainuo continued to sell ZILRETTA in Greater China.payments.

~~Subsequently, in July 2022, the Company submitted a termination letter to HK Tainuo associated with this license agreement.~~

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 3129

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Item 2. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

Management’s Discussion and Analysis of Financial Condition and Results of Operations is based upon our condensed consolidated financial statements, which have been prepared in accordance with generally accepted accounting principles in the United States of America (GAAP) and in accordance with the rules and regulations of the United States Securities and Exchange Commission, or SEC.

This Quarterly Report on Form 10-Q and certain other communications made by us contain forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and the Private Securities Litigation Reform Act of 1995, including, without limitation, statements related to: the Flexion Acquisition (as defined below) and the costs and benefits thereof, our growth and future operating results and trends, our strategy, plans, objectives, expectations (financial or otherwise) and intentions, future financial results and growth potential, including our plans with respect to the repayment of our indebtedness, anticipated product portfolio, development programs, patent terms, development of products, strategic alliances ~~patent terms~~ and intellectual property. For this purpose, any statement that is not a statement of historical fact should be considered a forward-looking statement. We often use the words “believe,” “anticipate,” “plan,” “estimate,” “expect,” “intend,” “may,” “will,” “would,” “could,” “can” and similar expressions to help identify forward-looking statements. We cannot assure you that our estimates, assumptions and expectations will prove to have been correct. Actual results may differ materially from these indicated by such forward-looking statements as a result of various important factors, including risks relating to, among others: risks associated with acquisitions, such as the risk that the acquired businesses will not be integrated successfully, that such integration may be more difficult, time-consuming or costly than expected or that the expected benefits of the transaction will not occur; the possibility that if we do not achieve the perceived benefits of the Flexion Acquisition as rapidly or to the extent anticipated by financial analysts or investors, the market price of our shares could decline; thelingering impact of the COVID-19 pandemic on elective surgeries, our manufacturing and supply chain, global and United States, or U.S., economic conditions (including inflation and rising interest rates), and our business, including our revenues, financial condition, cash flows and results of operations; the success of our sales and manufacturing efforts in support of the commercialization of EXPAREL® (bupivacaine liposome injectable suspension), ZILRETTA® (triamcinolone acetonide extended-release injectable suspension) and iovera°® ~~and~~; the rate and degree of market acceptance of EXPAREL, ZILRETTA and iovera°; the size and growth of the potential markets for EXPAREL, ZILRETTA and iovera° and our ability to serve those markets; our plans to expand the use of EXPAREL, ZILRETTA and iovera° to additional indications and opportunities, and the timing and success of any related clinical trials for EXPAREL, ZILRETTA and iovera°; the commercial success of EXPAREL, ZILRETTA and iovera°; the related timing and success of United States Food and Drug Administration, or FDA, supplemental New Drug Applications, or sNDAs, and premarket notification 510(k)s; the related timing and success of European Medicines Agency, or EMA, Marketing Authorization Applications, or ~~MAA;~~MAAs; our plans to evaluate, develop and pursue additional product candidates utilizing our proprietary multivesicular liposome, or pMVL, drug delivery technology; the approval of the commercialization of our products in other jurisdictions; clinical trials in support of an existing or potential pMVL-based product; our commercialization and marketing ~~capabilities,~~capabilities; our ability to successfully ~~construct~~complete an ~~additional~~ EXPAREL ~~manufacturing suite~~capacity expansion project in San Diego, California; our ability to successfully complete a ZILRETTA ~~capacity expansion~~capital project in Swindon, England; the outcome of any litigation; the ability to successfully integrate ~~Flexion or~~ any future acquisitions into our existing business; the recoverability of our deferred tax assets; and assumptions associated with contingent consideration payments.

Important factors could cause our actual results to differ materially from those indicated or implied by forward-looking statements, and as such we anticipate that subsequent events and developments will cause our views to change. Except as required by applicable law, we undertake no intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, and readers should not rely on the forward-looking statements as representing our views as of any date subsequent to the date of the filing of this Quarterly Report on Form 10-Q.

These forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance or achievements to differ materially from those expressed or implied by these statements. These factors include items mentioned herein and the matters discussed and referenced in Part I-Item 1A. “Risk Factors” included in our Annual Report on Form 10-K for the year ended December 31, ~~2021~~2022 (the “2022 Annual Report”) and in other reports as filed with the SEC.

Unless the context requires otherwise, references to “Pacira,” “we,” the “Company,” “us” and “our” in this Quarterly Report on Form 10-Q refer to Pacira BioSciences, Inc. and its subsidiaries.

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Overview

Pacira is the industry leader in our commitment to non-opioid pain management and providing a non-opioid ~~option~~pain management options to as many patients as possible to redefine the role of opioids as rescue therapy only. We are also developing innovative interventions to address debilitating conditions involving the sympathetic nervous system, such as cardiac electrical storm, chronic pain and spasticity. Our long-acting, local analgesic EXPAREL® (bupivacaine liposome injectable suspension) ~~was commercially launched in April 2012. EXPAREL~~ utilizes our unique pMVL drug delivery technology that encapsulates drugs without altering their molecular structure and releases them over a desired period of time. In the U.S., EXPAREL is the only opioid-free, long-acting local and regional analgesic approved for infiltration, field blocks and interscalene brachial plexus nerve block to produce local or regional postsurgical analgesia. EXPAREL is also approved for infiltration in pediatric patients aged six years and older in the U.S. In Europe, EXPAREL is approved as a brachial plexus block or femoral nerve block for treatment of post-operative pain in adults, and as a field block for treatment of somatic post-operative pain from small- to medium-sized surgical wounds in ~~adults.~~adults and children aged six years and older. Since its initial approval in 2011, more than 1012 million patients have been treated with EXPAREL. We drop-ship EXPAREL directly to end-users based on orders placed to wholesalers or directly to us, and there is no product held by wholesalers. With the acquisition ~~(the “Flexion Acquisition”)~~ of Flexion Therapeutics, Inc. ~~(“Flexion”)~~, or Flexion, in November 2021 (the “Flexion Acquisition”), we acquired ZILRETTA® (triamcinolone acetonide extended-release injectable suspension), the first and only extended-release, intra-articular therapy that can provide major relief for osteoarthritis, or OA, knee pain for three months and has the potential to become an alternative to hyaluronic acid, ~~or HA, and~~ platelet rich plasma ~~or PRP,~~ injections or other early intervention treatments. With the acquisition of MyoScience, Inc., or MyoScience, in April 2019 (the “MyoScience Acquisition”) ~~in April 2019,~~, we acquired iovera°®, a handheld cryoanalgesia device used to deliver a precise, controlled application of cold temperature ~~only~~ to targeted nerves, which we sell directly to end users. ~~The~~EXPAREL, ZILRETTA and the iovera° system isare highly complementary ~~to EXPAREL~~products as along-acting, non-opioid ~~therapy~~therapies that ~~alleviates pain by disrupting pain signals being transmitted to the brain from the site of injury or surgery. We also believe ZILRETTA is highly complementary to iovera°.~~

alleviate pain.

We expect to continue to pursue the expanded use of EXPAREL, ZILRETTA and iovera° in additional procedures; progress our earlier-stage product candidate pipeline; advance regulatory activities for EXPAREL, ZILRETTA, iovera° and our other product candidates; invest in sales and marketing resources for EXPAREL, ZILRETTA and iovera°; expand and enhance our manufacturing capacity for EXPAREL, ZILRETTA and iovera°; invest in products, businesses and technologies; and support legal matters.

~~Flexion Acquisition~~

In November 2021, we completed the Flexion Acquisition pursuant to an Agreement and Plan of Merger (the “Merger Agreement”), under which Flexion became our wholly owned subsidiary and added ZILRETTA, a non-opioid corticosteroid that employs a proprietary microsphere technology to provide extended pain relief, to our commercial offering. The addition of ZILRETTA to our innovative non-opioid product portfolio directly aligns with our mission to provide an opioid alternative to as many patients as possible and address medical needs along the neural pain pathway.

The total consideration of $578.8 million included an initial payment of $428.3 million which represented $8.50 in cash per share of Flexion common stock, $20.2 million paid to settle restricted stock units and in-the-money stock options, an $85.1 million cash payment to repay Flexion debt that was not assumed by us and $45.2 million in contingent consideration representing the fair value of contingent value rights, or CVRs, that were issued in conjunction with the Flexion Acquisition. The Merger Agreement provided for one non-tradeable CVR per share of Flexion common stock as well as one CVR per share for certain Flexion equity awards. Each CVR entitles Flexion shareholders to contingent milestone payments of up to an aggregate of $8.00 in cash per share of Flexion common stock if certain milestones are met on or prior to December 31, 2030. Up to an additional $380.2 million in the aggregate may be payable to holders of the CVRs if each of the applicable milestones are achieved. For more information, see Note 4, ~~Flexion Acquisition, to our condensed consolidated financial statements included herein.~~

~~Coronavirus (COVID-19) Pandemic and~~ Global Economic Conditions

Since early 2020, our revenues have been impacted by COVID-19 pandemic-related challenges that included the significant postponement or suspension in the scheduling of elective surgical procedures due to public health guidanceDirect and government directives. While the degree of impact has diminished during the course of the pandemic due to the introduction of vaccines and therapeutics, as well as the lessening of elective surgery restrictions, certain pandemic-related operational and staffing challenges persist. It remains unclear how long it will take the elective surgery market to normalize or if restrictions on elective procedures will recur due to future COVID-19 variants or otherwise. Directindirect effects of ~~the pandemic and~~ global economic conditions may negatively impact our business, financial condition and results of operations. Such impacts may include, but are not limited to, the effect of prolonged periods of inflation on our customers and suppliers and longer lead-times or the inability to

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secure a sufficient supply of materials. ~~The situation remains dynamic and subject to rapid and possibly material changes.~~ Additional negative impacts may also arise that we are unable to foresee. The nature and extent of such impacts are subject to material change, and will depend on future developments which are dynamic, highly uncertain and cannot be predicted.

We will continue to actively monitor the situation and implement measures recommended by federal, state or local authorities, or that we determine are in the best interests of our patients, employees, partners, suppliers, shareholders and stakeholders. For a description of risks facing us that relate to the COVID-19 pandemic or any other future pandemic, epidemic or outbreak of contagious disease, see our ~~Annual Report on Form 10-K for the year ended December 31, 2021~~.

~~Recent Highlights~~

•The U.S. Patent and Trademark Office issued Patent Nos. 11,304,904, and 11,311,486 in April 2022, and issued Patent No. 11,357,727 in June 2022. The ’904, ’486, and ’727 patents are listed in the FDA Approved Drug Products with Therapeutic Equivalence Evaluations (the “Orange Book”). With these three new patents, there are currently six EXPAREL patents listed in the Orange Book, each with an expiration date of January 22, 2041.

•In June 2022, we announced the launch of a partnership with the National Safety Council, or NSC, and the Connect2Prevent program. Connect2Prevent is an innovative employee-family educational program that increases awareness and prevention of opioid addiction. The NSC created a comprehensive curriculum designed to educate employees on the risks associated with opioids and provide them with the tools to have meaningful discussions with adolescent family members. The curriculum includes 10-12 weeks of engaging lessons on opioids, addiction, stigma, risk factors for substance use, refusal skills, harm reduction, how to talk to doctors about opioid alternatives and more. The lessons provide easy-to-understand education, action steps and evidence-based tools to connect and communicate with teens.

•In August 2022, we announced the completion of patient enrollment in our two Phase 3 studies of EXPAREL as a nerve block in lower extremity surgeries. The first study is evaluating EXPAREL as an adductor canal block for total knee arthroplasty, or TKA, and the second is evaluating EXPAREL as a popliteal sciatic nerve block for bunionectomy. We believe positive results from these studies will form the basis for an sNDA submission seeking label expansion to include lower extremity nerve blocks.

EXPAREL

In the U.S., EXPAREL is currently indicated for single-dose infiltration in patients six years of age and older ~~for single-dose infiltration~~ to produce postsurgical local analgesia and in adults as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia. Safety and efficacy have not been established in other nerve blocks. In ~~the E.U.,~~Europe, EXPAREL is ~~indicated~~approved as a brachial plexus block ~~and~~or femoral nerve block for treatment of post-operative pain in adults and as a field block for treatment of somatic post-operative pain from small- to medium-sized surgical wounds in ~~adults.~~adults, and in children aged 6 years or older as a field block for treatment of somatic post-operative pain from small- to medium-sized surgical wounds.

EXPAREL Label and Global Expansion

•Lower extremity nerve block. ~~We have completed enrollment in two Phase 3 registration studies~~The FDA is currently reviewing our sNDA seeking expansion of the EXPAREL as a nerve block in lower extremity surgeries. One is a popliteal sciatic nerve block for bunionectomy and the second is an adductor canal block for TKA. We believe positive results from these studies will form the basis for an sNDA submission seeking label ~~expansion~~ to include lower extremity nerve ~~blocks. We believe~~block procedures with a Prescription Drug User Fee Act, or PDUFA, action date of November 13, 2023. Our application is based on positive results from two Phase 3 registration studies. The first study, which evaluated EXPAREL admixed with bupivacaine HCl as a femoral nerve block in the ~~addition~~adductor canal in patients undergoing total knee arthroplasty, or TKA, achieved the primary endpoint, demonstrating a statistically significant reduction in cumulative pain scores from 0 to 96 hours compared with bupivacaine HCl (p<0.01). EXPAREL admixed with bupivacaine HCl also achieved a statistically significant reduction in postsurgical opioid consumption through 96 hours (p<0.01) compared with bupivacaine HCl, a key secondary endpoint. The second study, which evaluated EXPAREL as a sciatic nerve block in the popliteal fossa in patients undergoing bunionectomy, achieved the primary endpoint by demonstrating a statistically significant reduction in cumulative pain scores from 0 to 96 hours compared with bupivacaine HCl (p<0.00001). EXPAREL achieved a statistically significant reduction in postsurgical opioid consumption (p<0.00001) and a statistically significant percentage of ~~this indication is significant as anesthesia-driven regional approaches using nerve and field blocks continue to expand as institutional protocols.~~opioid-free subjects (p<0.001) through 96 hours

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compared with bupivacaine HCl, which were key secondary endpoints. EXPAREL was well tolerated with a safety profile consistent with bupivacaine HCl.

•Pediatrics.We ~~are working with the FDA~~expect to ~~finalize our studies~~initiate a Phase 1 pharmacokinetic study after which we would initiate a registration study to support expansion of the EXPAREL single-dose infiltration label to include patients under six years of age. ~~We have met with the FDA to discuss appropriate studies of EXPAREL in pediatric patients aged 0 to less than 6 years of age. We~~If successful, we expect ~~that these studies, if successful,~~this study, followed by a larger Phase 3 study, will ~~be the basis for an sNDA seeking~~support expansion of the EXPAREL ~~label to include this patient population for single-dose infiltration.~~labels in the U.S. and E.U. We are also discussing with the FDA, EMA and Medicines and Healthcare Products Regulatory Agency (MHRA) our regulatory strategy for EXPAREL administered as a nerve block in the pediatric setting. ~~We are working with both the FDA and the European Medicines Agency, or EMA, with the goal of harmonizing our pediatric clinical studies as much as possible between the two regions.~~

•Stellate ganglion block. Planning is underway for a multicenter registration study of EXPAREL as a stellate ganglion block for treating refractory cardiac ventricular dysrhythmias and for use to prevent postoperative atrial fibrillation after open heart surgery. We are working with a steering committee of Key Opinion Leaders in regional anesthesia and

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stellate ganglion blocks ~~who will convene later this year~~ to help finalize study design. After anwe meet with the FDA ~~meeting~~ to align on our regulatory strategy for expanding the EXPAREL label to include stellate ganglion block, we expect to proceed with a registration trial. We believe a stellate ganglion block utilizing EXPAREL will last for several days and address a significant unmet need in patients with ventricular and atrial dysrhythmias.

•Global expansion. We have prioritized the European ~~and Latin American markets~~market for global ~~expansion.~~expansion and launched EXPAREL in the U.K. and targeted E.U. countries in 2021. In Europe, ~~we were granted marketing authorization by the EC in November 2020 for~~ EXPAREL is approved as a brachial plexus block or femoral nerve block for treatment of ~~post-operating~~post-operative pain in adults and as a field block for treatment of somatic post-operative pain from small- to medium-sized surgical wounds in ~~adults. We launched EXPAREL~~adults, and as a field block for treatment of somatic post-operative pain from small- to medium-sized surgical wounds in ~~the U.K. and targeted E.U. countries in the fourth quarter of 2021.~~children aged six years or older. In Latin America, we have a distribution agreement with Eurofarma Laboratories S.A., or Eurofarma, for the development and commercialization of EXPAREL. Eurofarma has the exclusive right to market and distribute EXPAREL in 19 countries in Latin America, including Argentina, Brazil, Colombia and Mexico. In addition, Eurofarma will be responsible for regulatory filings for EXPAREL in these countries. We will receive royalties and are also eligible to receive regulatory- and commercial-based milestone payments that are triggered by the achievement of certain events.

ZILRETTA

ZILRETTA was approved by the FDA in October 2017 and launched in the U.S. shortly thereafter. We market ZILRETTA through our ZILRETTA and iovera° sales force of approximately 50 Treatment Solutions Managers who are providing clinicians with two unique OA treatment options to individualize patient care. ZILRETTA is the first and only extended-release, intra-articular therapy for ~~patients confronting~~ OA knee pain. ZILRETTA employs a proprietary microsphere technology combining triamcinolone acetonide, or TA, a commonly administered, immediate-release corticosteroid, with a poly lactic-co-glycolic acid, or PLGA, matrix to provide extended pain relief. PLGA is a proven extended-release delivery vehicle that is metabolized to carbon dioxide and water as it releases drug in the intra-articular space and is used in other approved drug products and surgical devices. The ZILRETTA microspheres slowly and continuously release triamcinolone acetonide into the knee to provide significant pain relief for 12 weeks, with some people experiencing pain relief through 16 weeks. ZILRETTA was approved by the FDA in October 2017 and launched in the U.S. shortly thereafter.

We believe ZILRETTA’s extended-release profile may also provide effective treatment for OA pain of the shoulder, and we intend to initiate a Phase 3 trial investigating ZILRETTA in shoulder OA in ~~2023 after aligning with the FDA on study design.~~2023. In addition, we are planning a study comparing ZILRETTA to immediate release ~~triamcinolone acetonide~~TA in patients with Type 2 diabetes and are evaluating a repeat dosing study.

ZILRETTA Clinical Benefits

ZILRETTA combines a commonly administered steroid, TA, with PLGA, delivering a 32 ~~milligram~~mg dose of TA to provide extended therapeutic concentrations in the joint and persistent analgesic effect.

Based on the strength of its pivotal and other clinical trials, we believe that ZILRETTA represents an important treatment option for the millions of patients in the U.S. in need of safe and effective extended relief from OA knee pain. The pivotal Phase 3 trial on which the approval of ZILRETTA was based showed that ZILRETTA significantly reduced OA knee pain for 12 weeks, with some people experiencing pain relief through ~~Week 16.~~16 weeks. Both the magnitude and duration of pain relief provided by ZILRETTA in clinical trials were clinically meaningful with the magnitude of pain relief ~~amongst~~among the largest seen to date in OA clinical trials. The overall frequency of treatment-related adverse events in these trials was similar to those observed with placebo, and no drug-related serious adverse events were reported. We believe that ZILRETTA holds the potential to become the corticosteroid of choice given its safety and efficacy profile, and the fact that it is the first and only extended-release corticosteroid on the market. In September 2021, the American Association of Orthopaedic Surgeons, or AAOS, updated its evidence-based clinical practice guidelines, finding ZILRETTA can improve patient outcomes over traditional immediate-release corticosteroids.

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iovera°

The iovera° system is ~~an FDA-approved,~~a non-opioid handheld cryoanalgesia device used to produce precise, controlled doses of cold temperature ~~only~~ to targeted nerves. It ~~has been~~is FDA 510(k) cleared in the U.S., has a CE mark in the E.U. and is cleared for marketing in Canada for the blocking of pain. We believe the iovera° system is highly complementary to EXPAREL and ZILRETTA as a non-opioid therapy that alleviates pain using a non-pharmacological nerve block to disrupt pain signals being transmitted to the brain from the site of injury or surgery. It is also indicated for the relief of pain and symptoms associated with arthritis of the knee for up to 90 days.

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iovera° Clinical Benefits

There is a growing body of clinical data demonstrating success with iovera° treatment for OA of the knee. Surgical intervention is typically a last resort for patients suffering from OA of the knee. In one study, the majority of the patients suffering from OA of the knee experienced pain relief up to 150 days after being treated with iovera°.

Preliminary findings demonstrated reductions in opioids, including:

•The daily morphine equivalent consumption in the per protocol group analysis was significantly lower at 72 hours (p<0.05), 6 weeks (p<0.05) and 12 weeks (p<0.05).

•Patients who were administered iovera° were far less likely to take opioids six weeks after surgery. The number of patients taking opioids six weeks after TKA in the control group was three times the number of patients taking opioids in the cryoanalgesia group (14% vs. 44%, p<0.01).

•Patients in the iovera° group demonstrated a statistically significant reduction in pain scores from their baseline pain scores at 72 hours (p<0.05) and at 12 weeks (p<0.05).

We believe these data validate iovera° as a clinically meaningful non-opioid alternative for patients undergoing TKA, and that iovera° offers the opportunity to provide patients with non-opioid pain control well in advance of any necessary surgical intervention through a number of key product attributes:

•iovera° is safe and effective with immediate pain relief that can last for months as the nerve regenerates over time;

•iovera° is repeatable;

•The iovera° technology does not risk damage to the surrounding tissue;

•iovera° is a convenient handheld device with a single-use procedure-specific Smart Tip; and

•iovera° can be delivered precisely using ultrasound guidance or an anatomical landmark.

In September 2021, the AAOS updated its evidence-based clinical practice guidelines, reporting that denervation therapy—including cryoneurolysis—may reduce knee pain and improve function in patients with symptomatic OA of the knee.

We are also encouraged by usage of iovera° in other areas. Key ~~opinion leaders~~Opinion Leaders in orthopedics, spine and anesthesia are interested in replacing heat-based radiofrequency ablation with iovera° cold therapy. There is interest across a wide range of treatment opportunities such as low back pain, spine, spasticity and rib fracture. We intend to use investigator-initiated studies and grants to develop data across these areas.

iovera° Global Expansion

In July 2021, we entered into a licensing agreement with Verve Medical Products, Inc. for the distribution of iovera° in Canada. We began selling iovera° in Canada in the fourth quarter of 2021. Additionally, we began selling iovera° in the E.U. through a contracted sales force in the first quarter of 2022.

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The Osteoarthritis Market

OA is the most common form of arthritis. It is also called degenerative joint disease and occurs most frequently in the hands, hips and knees. With OA, the cartilage within a joint begins to break down and the underlying bone begins to change. These changes usually develop slowly and ~~get worse~~worsen over time. OA can cause pain, stiffness and swelling. In some cases it also causes reduced function and ~~disability;~~ disability—some people are no longer able to do daily tasks or work. According to the ~~CDC,~~Centers for Disease Control and Prevention, OA affects over 32.5 million adults in the U.S.

The lifetime risk of developing symptomatic knee OA is 45 ~~percent.~~percent according to the Arthritis Foundation. The prevalence of symptomatic knee OA increases with each decade of life, with the annual incidence of knee OA being highest between age 55 and 64 years old. There are 14 million individuals in the U.S. who have symptomatic knee OA, and nearly two million are under the age of 45. Surgical intervention is typically a last resort for patients suffering from OA of the knee.

With the addition of ZILRETTA to our product offering, we can now offer clinicians the flexibility to individualize OA knee pain treatment with either ZILRETTA or a drug-free nerve block with iovera° based on patient factors and preference, physician training, site of care and reimbursement considerations.

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Clinical Development Programs

PCRX-201 ~~and PCRX-301 (Formerly FX-201 and FX-301)~~

PCRX-201 ~~and PCRX-301 were~~was added to our portfolio as part of the Flexion Acquisition. PCRX-201 is a novel, IA gene therapy product candidate ~~designed to provide “on demand” production of an~~that produces the anti-inflammatory protein, ~~interleukin-1 receptor antagonist (IL-1Ra) whenever inflammation is detected~~IL-1Ra, for treating OA pain in the ~~joint. PCRX-301, is~~knee. Based upon compelling initial Phase 1 efficacy and safety data for PCRX-201, we are preparing to initiate a ~~locally administered Na~~V~~1.7 inhibitor, known as funapide, formulated for extended release~~second Phase 1 study in OA of the knee and intend to request a ~~thermosensitive hydrogel. The initial development of PCRX-301 was intended to support administration as a peripheral analgesic lower extremity nerve block for management of post-operative pain.~~Regenerative Medicine Advanced Therapy, or RMAT, designation.

pMVL-Based Clinical Programs

Given the proven safety, flexibility and customizability of our pMVL drug delivery technology platform for acute, sub-acute and chronic pain applications, we have several pMVL-based products in clinical development. Following data readouts from preclinical and feasibility studies for these candidates, we have prioritized three programs for clinical development: (i) PCRX-401, a dexamethasone-pMVL for low back pain; (ii) PCRX-501, a high potency bupivacaine-pMVL for longer-lasting pain relief (20.0 mg/mL) and (iii) ~~a bupivacaine-pMVL~~EXPAREL for intrathecal analgesia (13.3 mg/mL). We ~~are planning to initiate~~initiated the second half of our Phase 1 study of ~~low-concentration bupivacaine-pMVL~~EXPAREL for intrathecal analgesia in ~~late 2022.~~June 2023.

External Innovation

In parallel to our internal clinical programs, our business development team ~~continues to pursue~~is pursuing innovative acquisition targets that are complementary to EXPAREL, ZILRETTA and iovera° and ~~that we believe~~ are of great interest to the surgical and anesthesia audiences we are already calling on today. We are using a combination of strategic investments, in-licensing and acquisition transactions to ~~build out~~buildout a pipeline of innovation to improve patients’ journeys along the neural pain pathway. ~~Select~~The strategic investments we have made to support promising early stage platforms are summarized ~~below.~~below:


Company	Development Stage	Description of Platform Technology	Potential Therapeutic Areas
~~Carthronix,~~CarthroniX, Inc.	~~Preclinical~~Phase 1-Ready	CX-011, a small molecule modulator of gp130 formulated as an intra-articular injection designed to slow joint degeneration by mediating IL-6 cytokines	Knee OA
~~Coda Therapeutics, Inc.~~	~~Preclinical~~	~~Chemogenetic platform to reverse the aberrant neuronal activity underlying neurological disorders using optimized Adeno-Associated Virus (AAV) vectors~~	~~Neuropathic pain~~
Genascence Corporation	Phase 11b	~~AAV vector-based~~Adeno-associated virus (AAV) based gene therapy ~~targeting Interleukin 1~~engineered to deliver Interleukin-1 Receptor Antagonist (IL-1Ra) to target cells in joint(s)	Knee OA
~~GeneQuine Biotherapeutics~~GQ Bio Therapeutics GmbH	Preclinical	~~Next-generation~~High capacity adenovirus (HCAd) based gene ~~transfer vehicles that enter joint~~therapy engineered to deliver DNA to target cells ~~to confer multi-year gene expression~~in joint(s) and intervertebral disc(s)	Knee OA and ~~other musculoskeletal disorders~~degenerative disc disease (DDD)
Spine BioPharma, LLC	Phase ~~3-ready~~3	~~Remedisc~~SB-01, a 7-amino acid chain peptide that binds to and induces down regulation of transforming growth factor, beta 1 (TGFβ1)	Degenerative disc disease (DDD)

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Product Portfolio and Internal Pipeline

Our current product portfolio and internal product candidate pipeline, along with anticipated milestones over the next 12 to 18 months, are summarized in the table below:

* Study designs have not been finalized for infiltration in pediatric patients aged 0 to 6 years old or for nerve block in pediatric patients.

~~- NOCITA~~® ~~is a registered trademark of Aratana Therapeutics, Inc., a wholly owned subsidiary of Elanco Animal Health, Inc.~~

Pacira Training Facilities

We maintain and operate two training facilities—one in Tampa, Florida and one in Houston, Texas. These sites were constructed with a singular goal in mind: to advance education on best practice techniques to effectively manage acute pain while reducing or eliminating the need for opioids. These facilities provide clinicians with flexible, state-of-the-art environments for interactive, hands-on instruction on the latest and most innovative local, regional and field block approaches for managing pain, improving patient care and enabling patient migration to the 23-hour stay environment.

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~~Pacira Training Facilities~~Tampa, Florida

In October 2020, we opened the Pacira Innovation and Training, ~~center~~or PIT, Center of ~~Tampa (the “PITT”).~~Tampa. We designed this facility to help advance clinician understanding of the latest local, regional and field block approaches for managing pain. The ~~PITT~~PIT of Tampa provides an unparalleled training environment for healthcare providers working to reduce or eliminate patient exposure to opioids. The ~~PITT~~PIT of Tampa supports a full range of educational events to advance clinician understanding of the latest local, regional, and field block approaches for managing pain and reducing or eliminating exposure to opioids. Our principal executive offices and corporate headquarters are also located at the ~~PITT.~~PIT of Tampa.

The ~~PITT~~PIT of Tampa consists of approximately 13,000 square-feet of fully adaptable space and is equipped with state-of-the-art technology and audio/visual capabilities and features several distinct training spaces including a simulation lab equipped with seven ultrasound scanning stations; a lecture hall featuring a 4½-foot tall by 24-foot wide liquid crystal display video wall to support live, virtual and even global presentations; and a green-screen broadcast studio designed to livestream content with single or multiple hosts.

In addition to our EXPAREL programs, we are hosting ongoing workshops to train new users on best practice techniques for iovera° administration at the ~~PITT.~~PIT of Tampa. Led by healthcare professionals, these labs include didactic lectures and hands-on trainings including live model nerve scanning and identification using ultrasound and peripheral nerve stimulation.

At no fee to the organization, the ~~PITT~~PIT of Tampa also serves as a venue for national anesthesia provider organizations to host their own workshops and training sessions to educate healthcare providers.

~~We have launched development plans for a~~Houston, Texas

In January 2023, we opened our second training facility, the Houston Pacira Innovation and Training Center, in Houston, Texas. This 19,000 square-foot state-of-the-art facility ~~will feature an~~features a 125-seat adaptive lecture hall featuring the same liquid crystal display video wall that the PIT of Tampa has, a broadcast studio and both wet and dry lab space for cadaver and other interactive workshops. ~~These~~A simulation lab is equipped with eight advanced ultrasound machines equipped with artificial intelligence and 3-D training ~~centers are~~software in addition to professional medical lighting and in-ceiling cameras. The PIT of Houston is core to developing both our physician champions and community-based clinicians who want to stay on the forefront of opioid-sparing pain management. ~~We expect to open~~With this new training facility, ~~before the end of 2022 which would immediately double~~we have doubled our capacity and ability to host programs for EXPAREL, ZILRETTA and iovera°.

Results of Operations

Comparison of the Three and Six Months Ended June 30, ~~2022~~2023 and ~~2021~~2022

Revenues

~~Net product~~Total revenues consist of sales ~~consist~~ of (i) EXPAREL in the U.S., ~~the European Union, or~~ E.U., and ~~the United Kingdom, or~~ U.K.; (ii) ZILRETTA in the U.S.; (iii) iovera° in the U.S., Canada and the E.U. and (iv) sales of, and royalties on, our bupivacaine liposome injectable suspension primarily for veterinary use.

The following table provides information regarding our revenues during the periods indicated, including percent changes (dollar amounts in thousands):


		Three Months Ended June 30,					% Increase / (Decrease)	Six Months Ended June 30,						% Increase / (Decrease)		Three Months Ended June 30,						% Increase / (Decrease)	Six Months Ended June 30,					% Increase / (Decrease)

						2022				2021			2022				2021				2023		2022				2023		2022
Net product sales:	Net product sales:																	Net product sales:
EXPAREL	EXPAREL	$	137,007	$	130,058		5%	$	266,212		$	244,736		9%	EXPAREL	$	135,127		$	137,007		(1)%	$	265,535	$	266,212		(0)%
ZILRETTA	ZILRETTA	27,417		—			N/A	51,052			—			N/A	ZILRETTA	29,261			27,417			7%	53,595		51,052			5%
iovera°	iovera°	3,201		3,813			(16)%	6,227			7,081			(12)%	iovera°	4,384			3,201			37%	8,385		6,227			35%
Bupivacaine liposome injectable suspension	Bupivacaine liposome injectable suspension	956		992			(4)%	2,512			1,784			41%	Bupivacaine liposome injectable suspension	695			956			(27)%	1,383		2,512			(45)%
Total net product sales	Total net product sales	168,581		134,863			25%	326,003			253,601			29%	Total net product sales	169,467			168,581			1%	328,898		326,003			1%
Royalty revenue	Royalty revenue	830		602			38%	1,399			891			57%	Royalty revenue	—			830			(100)%	910		1,399			(35)%
Collaborative licensing and milestone revenue		—		125			(100)%	—			125			(100)%

Total revenues	Total revenues	$	169,411	$	135,590		25%	$	327,402		$	254,617		29%	Total revenues	$	169,467		$	169,411		0%	$	329,808	$	327,402		1%

Pacira BioSciences, Inc. | Q2 2023 Form 10-Q | Page 36

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EXPAREL revenue ~~increased 5%~~decreased 1% in the three months ended June 30, 2023 and 9%remained flat in the six months ended June 30, 2023 versus 2022, primarily due to enrolling EXPAREL in the 340B drug pricing program, resulting in greater discounts, and other strategic partnerships as well as the sales mix of EXPAREL vial sizes. These decreases were largely offset by increases of 4.2% and 5.2% in gross vial volume and increases of 4.4% and 4.3% in gross selling price per unit in the three and six months ended June 30, 2023 versus 2022, ~~versus 2021, respectively, primarily due to increases of 3.6% and 7.2% in gross vial volume and increases of 3.7% and 3.8% in gross selling price per~~

~~Pacira BioSciences, Inc. | Q2 2022 Form 10-Q | Page 39~~

~~Table of Contents~~

~~unit, partially offset by the sales mix of EXPAREL vial sizes. Although the~~respectively. The demand for EXPAREL has ~~continued to increase primarily as a result of Ambulatory Surgical Centers~~increased with ASCs and anesthesiologists broadening the use of long-acting EXPAREL regional approaches as a foundation of multimodal opioid-minimization strategies that enable shifting inpatient procedures to 23-hour sites of care and among those customers that are eligible to participate in the 340B drug pricing program. While the elective surgery market has faced ~~additional pandemic-related~~post-pandemic-related challenges ~~due to regional surges in COVID-19 variant cases, staffing shortages~~ and ~~fatigue from care teams addressing significant procedure backlogs.~~global economic pressures, EXPAREL utilization remains above the overall ~~sharp~~ decline in elective surgical procedures relative to pre-pandemic baseline levels due to increased utilization in outpatient settings and emergent procedures.

~~As a result of the Flexion Acquisition, we acquired~~ ZILRETTA ~~in November 2021, which is an extended-release corticosteroid treatment for OA knee pain. We recognized net product sales of $27.4 million~~revenue increased 7% and ~~$51.1 million for the three and six months ended June 30, 2022, respectively.~~

~~Net product sales of iovera° decreased 16% and 12%~~5% in the three and six months ended June 30, ~~2022~~2023 versus ~~2021,~~2022, respectively, primarily due to ~~a delay~~increases of 8.1% and 5.4% in gross kit volume and increases of 2.0% and 2.9% in gross selling price per unit during the applicable periods and was partially offset by higher customer discounting primarily due to expanded contracting efforts.

Net product sales of iovera° increased 37% and 35% in the ~~transition from generation 1~~three and six months ended June 30, 2023 versus 2022, respectively, due to ~~generation 2 iovera° products~~increases of 38% in Smart Tip volume in both periods and ~~short-term variations~~increases of 6.7% and 3.1% in ~~reimbursement policies in certain territories.~~gross selling price per Smart Tip, partially offset by higher customer discounting.

Bupivacaine liposome injectable suspension net product sales decreased 27% and ~~its related royalties increased nominally~~45% in the three ~~months ended June 30, 2022 versus 2021. Bupivacaine liposome injectable suspension net product sales~~ and ~~its related royalties increased in the~~ six months ended June 30, 2023 versus 2022, respectively. Its related royalties decreased 100% and 35% in the three and six months ended June 30, 2023 versus ~~2021. These changes versus the prior year periods were~~2022, respectively, primarily due to the timing and product mix of orders ~~placed~~and related sales made by Aratana Therapeutics, Inc. for veterinary use.

~~Any renewed government suspension of or reluctance of patients to have elective procedures would impact our future sales of EXPAREL, ZILRETTA and iovera° during the ongoing COVID-19 pandemic.~~

The following tables provide a summary of activity with respect to our sales related allowances and accruals related to EXPAREL and ZILRETTA for the six months ended June 30, ~~2022~~2023 and ~~2021~~2022 (in thousands):

June 30, 2022 Returns Allowances Prompt Payment Discounts Service
Fees Volume
Rebates and
Chargebacks Government Rebates Total
Balance at December 31, 2021 $ 3,361 $ 1,178 $ 3,636 $ 3,494 $ 761 $ 12,430
Provision 817 5,470 8,123 19,191 754 34,355
Payments / Adjustments (2,503) (5,540) (8,876) (18,960) (740) (36,619)
Balance at June 30, 2022 $ 1,675 $ 1,108 $ 2,883 $ 3,725 $ 775 $ 10,166


June 30, 2023	Returns Allowances		Prompt Payment Discounts		Service Fees		Volume Rebates and Chargebacks		Government Rebates		Total
Balance at December 31, 2022	$	1,691	$	1,187	$	3,193	$	5,452	$	786	$	12,309
Provision	1,122		5,952		8,895		46,936		1,027		63,932
Payments / Adjustments	(956)		(5,918)		(8,677)		(45,659)		(982)		(62,192)
Balance at June 30, 2023	$	1,857	$	1,221	$	3,411	$	6,729	$	831	$	14,049

June 30, 2021 Returns Allowances Prompt Payment Discounts Service
Fees Volume
Rebates and
Chargebacks Government
Rebates Total
Balance at December 31, 2020 $ 1,023 $ 1,007 $ 1,168 $ 1,600 $ — $ 4,798
Provision 498 5,050 3,806 6,238 — 15,592
Payments / Adjustments (261) (4,631) (3,846) (5,814) — (14,552)
Balance at June 30, 2021 $ 1,260 $ 1,426 $ 1,128 $ 2,024 $ — $ 5,838


June 30, 2022	Returns Allowances		Prompt Payment Discounts		Service Fees		Volume Rebates and Chargebacks		Government Rebates		Total
Balance at December 31, 2021	$	3,361	$	1,178	$	3,636	$	3,494	$	761	$	12,430
Provision	817		5,470		8,123		19,191		754		34,355
Payments / Adjustments	(2,503)		(5,540)		(8,876)		(18,960)		(740)		(36,619)
Balance at June 30, 2022	$	1,675	$	1,108	$	2,883	$	3,725	$	775	$	10,166

Total reductions of gross product sales from sales-related allowances and accruals were $63.9 million and $34.4 million, or 16.3% and ~~$15.6 million, or~~ 9.6% ~~and 5.8%~~ of gross product sales, for the six months ended June 30, ~~2022~~2023 and ~~2021,~~2022, respectively. The overall 6.7% increase in sales-related allowances and accruals as a percentage of gross product sales was primarily related to accruals as a result of enrolling EXPAREL in the ~~addition of the ZILRETTA-related allowances~~340B drug pricing program and ~~accruals.~~chargeback-related allowances.

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 4037

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Cost of Goods Sold

Cost of goods sold primarily relates to the costs to produce, package and deliver our products to customers. These expenses include labor, raw materials, manufacturing overhead and occupancy costs, depreciation of facilities, royalty payments, quality control and engineering.

The following table provides information regarding our cost of goods sold and gross margin during the periods indicated, including percent changes (dollar amounts in thousands):


		Three Months Ended June 30,							% Increase / (Decrease)		Six Months Ended June 30,									% Increase / (Decrease)		Three Months Ended June 30,									% Increase / (Decrease)		Six Months Ended June 30,							% Increase / (Decrease)

								2022				2021							2022				2021						2023				2022					2023				2022
Cost of goods sold	Cost of goods sold	$	50,627		$	35,248				43%			$	86,701			$	66,597				30%			Cost of goods sold	$	48,207			$	50,627	(5)%			$	97,227			$	86,701	12%
Gross margin	Gross margin	70		%	74		%				74	%			74	%					Gross margin	72		%			70	%					71	%		74	%

Gross margin ~~decreased four percentage points~~increased two percentage-points in the three months ended June 30, ~~2022~~2023 versus ~~2021~~2022, mainly due to higher costs in 2022 for the transition of manufacturing sites for iovera°, partially offset by an increase in sales-related allowances and accruals as a result of enrolling EXPAREL ~~inventory reserves due to raw material supply chain delays and~~in the ~~ZILRETTA step-up of fixed assets and inventory to fair value~~340B drug pricing program which resulted in ~~accordance with purchase accounting. There was no change~~a lower net selling price in ~~gross~~the current period.

Gross margin decreased three percentage-points in the six months ended June 30, 2023 versus 2022, ~~versus 2021, when a two percentage point increase due to the prior period’s unplanned downtime was offset by a two percentage point decrease~~mainly due to higher EXPAREL product cost due to operational challenges at our third-party contract manufacturing site in Swindon, England and discounting resulting in a lower net selling price in the current period, partially offset by higher costs in 2022 for the transition of manufacturing sites for iovera° and ZILRETTA product costs due to a fair value step-up of inventory ~~reserves attributable to raw material supply chain delays.~~and fixed assets acquired in the Flexion Acquisition.

Research and Development Expenses

Research and development expenses primarily consist of costs related to clinical trials and related outside services, product development and other research and development costs, including trials that we are conducting to generate new data for EXPAREL, ZILRETTA and iovera° and stock-based compensation expense. Clinical and preclinical development expenses include costs for clinical personnel, clinical trials performed by third-parties, toxicology studies, materials and supplies, database management and other third-party fees. Product development and manufacturing capacity expansion expenses include development costs for our products, which include personnel, equipment, materials and contractor costs for process development and product candidates, development costs related to significant scale-ups of our manufacturing capacity and facility costs for our research space. Regulatory and other expenses include regulatory activities related to unapproved products and indications, medical information expenses, registry expenses and related personnel. Stock-based compensation expense relates to the costs of stock option grants, awards of restricted stock units, or RSUs, and our employee stock purchase plan, or ESPP.

The following table provides a breakout of our research and development expenses during the periods indicated, including percent changes (dollar amounts in thousands):


		Three Months Ended June 30,							% Increase / (Decrease)		Six Months Ended June 30,											% Increase / (Decrease)		Three Months Ended June 30,										% Increase / (Decrease)		Six Months Ended June 30,									% Increase / (Decrease)

								2022					2021								2022				2021							2023				2022							2023				2022
Clinical and preclinical development	Clinical and preclinical development	$	17,734		$	5,111				100%+				$	31,174				$	13,131				100%+			Clinical and preclinical development	$	5,194				$	17,734	(71)%				$	10,455				$	31,174	(66)%
Product development and manufacturing capacity expansion	Product development and manufacturing capacity expansion	5,080			4,607				10%		10,073					9,309						8%	Product development and manufacturing capacity expansion	9,305					5,080					83%		16,977				10,073					69%
Regulatory and other	Regulatory and other	1,948			1,526				28%		3,662					3,578						2%	Regulatory and other	2,603					1,948					34%		4,935				3,662					35%
Stock-based compensation	Stock-based compensation	1,520			1,329				14%		2,978					2,435						22%	Stock-based compensation	1,722					1,520					13%		3,597				2,978					21%
Total research and development expense	Total research and development expense	$	26,282		$	12,573			100%+		$	47,887				$	28,453					68%	Total research and development expense	$	18,824				$	26,282				(28)%		$	35,964			$	47,887				(25)%
% of total revenues	% of total revenues	16		%	9		%				15		%			11		%					% of total revenues	11		%			16		%					11		%		15		%

Total research and development expense ~~increased over 100%~~decreased 28% and ~~68%~~25% in the three and six months ended June 30, ~~2022~~2023 versus ~~2021,~~2022, respectively.

Clinical and preclinical development expense ~~increased over 100%~~decreased 71% and 66% in ~~each of~~ the three and six months ended June 30, 2023 versus 2022, ~~versus 2021,~~respectively, due to the ~~start-up~~completion of ~~and continued enrollment in~~ two EXPAREL lower extremity nerve block trials in bunionectomy and

Pacira BioSciences, Inc. | Q2 2023 Form 10-Q | Page 38

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TKA ~~and ongoing trials~~in the third quarter of 2022, toxicology studies that are near completion for ~~the~~ product candidates and the completion of a trial in the second quarter of 2022 for a former product candidate that was acquired ~~as part of the Flexion Acquisition.~~from Flexion.

Product development and manufacturing capacity expansion expense increased ~~10%~~83% and 8%69% in the three and six months ended June 30, ~~2022~~2023 versus ~~2021,~~2022, respectively, mainly attributable to the ~~significant~~continued scale-up activities of our EXPAREL manufacturing capacity at our Science Center Campus in San Diego, ~~California.~~

~~Pacira BioSciences, Inc. | Q2 2022 Form 10-Q | Page 41~~

~~Table~~California, as well as new product development costs related to cell and gene therapy, including those in support of ~~Contents~~

PCRX-401.

Regulatory and other expense increased ~~28%~~34% and 2%35% in the three and six months ended June 30, ~~2022~~2023 versus ~~2021,~~2022, respectively, due to increased ~~support of E.U. EXPAREL pediatric submissions, partially offset by lower ongoing costs in 2022~~enrollment and additional sites related to ~~our~~an observational iovera° ~~clinical data~~ registry ~~as compared~~study which tracks patients’ symptoms and experience with pain management related to ~~start-up expenses incurred in~~OA of the ~~first half of 2021.~~knee, and increased medical information publications.

Stock-based compensation increased ~~14%~~13% and ~~22%~~21% in the three and six months ended June 30, ~~2022~~2023 versus ~~2021,~~2022, respectively, primarily due to greater equity awards outstanding for research and development ~~personnel.~~personnel, partially offset by a lower fair value of newer equity awards granted.

Selling, General and Administrative Expenses

Sales and marketing expenses primarily consist of compensation and benefits for our sales force and personnel that support our sales, marketing, medical and scientific affairs operations, ~~payments to our marketing partners for the promotion and sale of our products,~~ expenses related to communicating the health outcome benefits of our products, investments in provider-level market access and patient reimbursement support and educational programs for our customers. General and administrative expenses consist of compensation and benefits for legal, finance, regulatory activities related to approved products and indications, compliance, information technology, human resources, business development, executive management and other supporting personnel. It also includes professional fees for legal, audit, tax and consulting services. Stock-based compensation expense relates to the costs of stock option grants, RSU awards and our ESPP.

The following table provides information regarding our selling, general and administrative expenses during the periods indicated, including percent changes (dollar amounts in thousands):


		Three Months Ended June 30,							% Increase / (Decrease)		Six Months Ended June 30,											% Increase / (Decrease)		Three Months Ended June 30,										% Increase / (Decrease)		Six Months Ended June 30,									% Increase / (Decrease)

								2022					2021								2022				2021							2023				2022							2023				2022
Sales and marketing	Sales and marketing	$	36,854		$	28,259				30%				$	75,294				$	55,361				36%			Sales and marketing	$	37,462				$	36,854	2%				$	79,041				$	75,294	5%
General and administrative	General and administrative	19,603			14,887				32%		37,044					28,755						29%	General and administrative	19,591					19,603					(0)%		40,464				37,044					9%
Stock-based compensation	Stock-based compensation	8,546			7,667				11%		16,925					15,219						11%	Stock-based compensation	7,797					8,546					(9)%		16,188				16,925					(4)%
Total selling, general and administrative expense	Total selling, general and administrative expense	$	65,003		$	50,813			28%		$	129,263				$	99,335					30%	Total selling, general and administrative expense	$	64,850				$	65,003				(0)%		$	135,693			$	129,263				5%
% of total revenues	% of total revenues	38		%	37		%				39		%			39		%					% of total revenues	38		%			38		%					41		%		39		%

Total selling, general and administrative ~~expenses~~expense was flat in the three months and increased ~~28%~~5% in the six months ended June 30, 2023 versus 2022, respectively.

Sales and ~~30%~~marketing expense increased 2% and 5% in the three and six months ended June 30, 2023 versus 2022, ~~versus 2021,~~ respectively,

~~Sales and marketing expenses increased 30% and 36% in the three and six months ended June 30, 2022 versus 2021, respectively. The increases were~~ driven by ~~a sales force expansion supporting iovera°, the addition of a sales force to support ZILRETTA and fully staffing a contracted sales force~~an increase in ~~Europe. We are continuing~~marketing investments in our ~~marketing investment in EXPAREL and iovera°, which includes~~products, including educational initiatives and programs related to the impact of opioids and postsurgical pain management and our national advocacy campaign designed to educate patients about non-opioid treatment options. ~~Additionally, we continue~~We also have invested in strategic partnerships with sports organizations, such as the Ladies Professional Golf Association (LPGA) and National Football League Alumni Association (NFLA), to increase awareness of the availability and benefits of non-opioid options to manage acute and chronic pain for athletes, including postsurgical pain and knee OA. We also expanded our investment in clinician training in the use of EXPAREL and iovera° at our ~~PITT~~ training facility in Tampa, ~~Florida. The addition~~as well as the opening of ~~ZILRETTA to our commercial portfolio has increased our sales and marketing spend~~a second training facility in 2022 as we increased the size of our ZILRETTA and iovera° sales force, which is providing clinicians with two unique OA treatment options to individualize patient care and patient reimbursement support for ZILRETTA.Houston, Texas in January 2023.

General and administrative ~~expenses~~expense was flat in the three months and increased ~~32%~~9% in the six months ended June 30, 2023 versus 2022, respectively, primarily driven by legal fees attributable to ongoing litigation. For more information, see Note 15, Commitments and ~~29% in~~Contingencies, to our condensed consolidated financial statements included herein.

Stock-based compensation decreased 9% and 4% for the three and six months ended June 30, 2023 versus 2022, versus 2021, respectively. The increases were driven by administrative support costs as a result of the Flexion Acquisition in November 2021, including transition expenses during integration, and additional support for our expansion into European markets. The increase in the six months ended June 30, 2022 also includes legal costs to support intellectual property protection.

~~Stock-based compensation increased 11% in both the three and six months ended June 30, 2022 and 2021~~respectively, primarily due to ~~an increase~~a decrease in the number of equity awards outstanding for selling, general and administrative personnel.

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 4239

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Amortization of Acquired Intangible Assets

The following table provides a summary of the amortization of acquired intangible assets during the periods indicated, including percent changes (dollar amounts in thousands):
Three Months Ended
June 30, % Increase / (Decrease) Six Months Ended
June 30, % Increase / (Decrease)
2022 2021 2022 2021
Amortization of acquired intangible assets $ 14,322 $ 1,967 100% + $ 28,644 $ 3,933 100% +


	Three Months Ended June 30,				% Increase / (Decrease)	Six Months Ended June 30,				% Increase / (Decrease)

	2023		2022			2023		2022
Amortization of acquired intangible assets	$	14,322	$	14,322	—%	$	28,644	$	28,644	—%

~~Amortization~~As part of the Flexion Acquisition and the MyoScience Acquisition, we acquired intangible assets ~~increased substantially in the three and six months ended June 30, 2022 versus 2021 due to the Flexion Acquisition. We acquired a~~consisting of developed technology intangible ~~asset for ZILRETTA for OA knee pain, which is being amortized over a~~assets and customer relationships, with estimated useful ~~life of approximately ten~~lives between 9 and 14 years. For more information, see Note 4, ~~Flexion Acquisition,~~ ~~and Note 8,~~7, Goodwill and Intangible Assets, to our condensed consolidated financial statements included herein.

Acquisition-Related (Gains) Charges, ~~Product Discontinuation~~Restructuring Charges and Other

The following table provides a summary of the costs related to the Flexion Acquisition, ~~MyoScience Acquisition, termination costs~~restructuring charges and other activities during the periods indicated, including percent changes (dollar amounts in thousands):

Three Months Ended
June 30, % Increase / (Decrease) Six Months Ended
June 30, % Increase / (Decrease)
2022 2021 2022 2021
Acquisition-related (gains) charges, net $ (18,058) $ 146 N/A $ (13,721) $ (981) (100)%+
Other — — N/A — 3,000 (100)%
Total acquisition-related (gains) charges, product discontinuation and other $ (18,058) $ 146 N/A $ (13,721) $ 2,019 N/A


	Three Months Ended June 30,				% Increase / (Decrease)	Six Months Ended June 30,				% Increase / (Decrease)

	2023		2022			2023		2022
Acquisition-related (gains) charges, net	$	(17,549)	$	(18,058)	(3)%	$	(5,442)	$	(13,721)	(60)%
Restructuring charges	936		—		N/A	936		—		N/A

Total acquisition-related (gains) charges, restructuring charges and other	$	(16,613)	$	(18,058)	(8)%	$	(4,506)	$	(13,721)	(67)%

Total acquisition-related (gains) charges, ~~product discontinuation~~restructuring charges and other ~~increased substantially~~decreased 8% and 67% in the three and six months ended June 30, ~~2022~~2023 versus ~~2021.~~2022.

During the three and six months ended June 30, 2023, we recognized acquisition-related gains, net of $17.5 million and $5.4 million, respectively. These gains were primarily due to adjustments to long-term forecasts which reduced the probability of meeting the sales-based contingent consideration milestones for the Flexion Acquisition by December 31, 2030, the expiration date for achieving the milestones. The gains recognized during the six months ended June 30, 2023 were partially offset by a decrease in the assumed discount rate that is utilized in calculating the liability’s present value, based on a significant improvement in the Company’s incremental borrowing rate. In addition, in June 2023 we implemented a restructuring plan in an effort to improve our operational efficiencies and recognized $0.9 million in one-time employee termination benefits through a reduction of headcount. For more information, see Note 9, Financial Instruments and Note 14, Acquisition-Related (Gains) Charges, Restructuring Charges and Other, to our condensed consolidated financial statements included herein.

During the three and six months ended June 30, 2022, we recognized acquisition-related gains, net of $18.1 million and $13.7 million, respectively. These gains were primarily driven by reductions in acquisition contingent consideration liabilities due to adjustments to near-term forecasts for the applicable period during which the Flexion contingent consideration may be achieved under the Merger Agreement and due to the reduced probability of meeting the MyoScience contingent consideration milestones by December 31, 2023, the expiration date for achieving the milestones. These gains were partially offset by severance, legal fees, third-party services and other one-time charges related to the Flexion Acquisition. ~~For more information, see~~See Note ~~10,~~ ~~Financial Instruments, and Note 15,~~14, Acquisition-Related (Gains) Charges, ~~Product Discontinuation~~Restructuring Charges and Other,~~, to our condensed consolidated financial statements included herein.~~

In the three and six months ended June 30, 2021, as part of the MyoScience Acquisition, we recognized acquisition-related charges of $0.1 million and gains of $1.0 million, respectively, primarily related to changes in the fair value of contingent consideration. See Note 10, ~~Financial Instruments~~, to our condensed consolidated financial statements included herein, for ~~information regarding the methods and key assumptions used in the fair value measurements of contingent consideration.~~more information.

In June 2018, we entered into an agreement with Nuance Biotech Co. Ltd. to advance the development and commercialization of EXPAREL in China. In April 2021, we agreed to a mutual termination of the agreement due to the lack of a viable regulatory pathway that adequately safeguards our intellectual property against the risk of a generic product. Dissolution costs of $3.0 million were included in other operating expenses in the condensed consolidated statements of operations for the six months ended June 30, 2021.

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 4340

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Other ~~Income (Expense)~~Expense, Net

The following table provides information regarding other expense, net during the periods indicated, including percent changes (dollar amounts in thousands):


		Three Months Ended June 30,					% Increase / (Decrease)		Six Months Ended June 30,								% Increase / (Decrease)		Three Months Ended June 30,								% Increase / (Decrease)		Six Months Ended June 30,							% Increase / (Decrease)

						2022					2021					2022				2021					2023				2022					2023				2022
Interest expense																		Interest expense	$	(3,865)			$	(8,833)			(56)%		$	(13,454)		$	(19,079)			(29)%
Interest income	Interest income	$	252	$	224			13%				$	523		639				(18)%		Interest income	2,111				252		100% +			5,253				523		100%+
Interest expense		(8,833)		(7,023)			26%		(19,079)					(13,994)			36%

Loss on early extinguishment of debt																		Loss on early extinguishment of debt	—				—				N/A		(16,926)			—				N/A
Other, net	Other, net	(647)		(2,396)			(73)%		(771)					(2,554)			(70)%	Other, net	(269)				(647)				(58)%		(279)			(771)				(64)%
Total other expense, net	Total other expense, net	$	(9,228)	(9,195)			—%		$	(19,327)				(15,909)			21%	Total other expense, net	$	(2,023)			(9,228)				(78)%		$	(25,406)		$	(19,327)			31%

Total other expense, net ~~increased nominally and 21%~~decreased 78% in the three months ended June 30, 2023 and increased 31% in the six months ended June 30, ~~2022~~2023 versus ~~2021, respectively.~~ 2022.

The ~~26%~~56% and ~~36% increase~~29% decrease in interest expense during the three and six months ended June 30, ~~2022,~~2023, respectively, was ~~due~~primarily driven by entering into the TLA Term Loan (as defined below) in March 2023 in order to ~~the $375.0 million~~retire our term loan B and related credit agreement (the ~~“Term~~“TLB Term Loan”) ~~entered into in December 2021. This increase was partially offset by~~, and, to a lesser extent, the absence ~~of debt discount amortization associated with our convertible notes in the current year due to adopting Accounting Standards Update, or ASU, 2020-06 in 2022, and the maturing~~ of our 2.375% convertible senior notes ~~due 2022, or 2022 Notes, on~~that matured in April 1, 2022. ~~For additional information regarding~~Retiring our TLB Term Loan is expected to significantly further reduce our 2023 full-year interest expense as our new TLA Term Loan carries approximately $140.0 million less principal and an interest rate that is 400 basis points lower than the ~~adoption of ASU 2020-06, see Note 2, Summary of Significant Accounting Policies,~~ ~~to our condensed consolidated financial statements herein.~~interest rate applicable under the TLB Term Loan.

~~Other, net~~The increase in ~~the prior year periods included a realized loss on the sale of an equity investment~~interest income in ~~the amounts of $2.5 million and $2.6 million during~~ the three and six months ended June 30, ~~2021, respectively.~~2023 versus 2022 was due to higher interest rates and overall investment balances.

In conjunction with the entry into the TLA Credit Agreement (as defined below), we incurred a $16.9 million loss on early extinguishment of debt recognized as a result of the retirement of $287.5 million aggregate principal of our TLB Term Loan. For more information, see Note 8, Debt, to our condensed consolidated financial statements included herein.

Income Tax Expense

The following table provides information regarding our income tax expense during the periods indicated, including percent changes (dollar amounts in thousands):
Three Months Ended
June 30, % Increase / (Decrease) Six Months Ended
June 30, % Increase / (Decrease)
2022 2021 2022 2021
Income tax expense $ 2,131 $ 6,567 (68)% $ 2,597 $ 8,921 (71)%
Effective tax rate 10 % 26 % 9 % 23 %


	Three Months Ended June 30,						% Increase / (Decrease)	Six Months Ended June 30,						% Increase / (Decrease)

	2023			2022				2023			2022
Income tax expense	$	12,091		$	2,131		100% +	$	5,153		$	2,597		98%
Effective tax rate	32		%	10		%		45		%	9		%

The effective tax rates were 32% and 45% for the three and six months ended June 30, 2023, respectively. The effective tax rates were 10% and 9% for the three and six months ended June 30, 2022, ~~respectively. The effective tax rates were 26% and 23% for the three and six months ended June 30, 2021,~~ respectively. Income tax expense represents the estimated annual effective tax rate applied to the year-to-date domestic operating results adjusted for certain discrete tax items.

The effective tax rate for the three and six months ended June 30, 2023 includes costs related to non-deductible stock-based compensation, a valuation allowance recorded against non-U.S. results and non-deductible executive compensation. The effective tax rates for the three and six months ended June 30, 2022 include benefits related to stock-based compensation, a first quarter milestone payment to SkyePharma Holding, Inc.~~, or Skyepharma,~~ (now a subsidiary of Vectura Group plc), ~~milestone payment~~or Skyepharma, and a fair value adjustment for Flexion contingent consideration, offset by ~~non-deductible~~nondeductible executive compensation costs and a valuation allowance against non-U.S. results. The effective tax rates for the three and six months ended June 30, 2021 include benefits related to stock-based compensation offset by non-deductible executive compensation costs and valuation allowances recorded against deductible capital losses and non-U.S. results.

Pacira BioSciences, Inc. | Q2 2023 Form 10-Q | Page 41

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Liquidity and Capital Resources

Since our inception in 2006, we have devoted most of our cash resources to manufacturing, research and development and selling, general and administrative activities related to the development and commercialization of EXPAREL. In addition, we acquired ZILRETTA as part of the Flexion Acquisition in November 2021 and iovera° as part of the MyoScience Acquisition in April 2019. We are primarily dependent on the commercial success of EXPAREL and ZILRETTA. We have financed our operations primarily with the proceeds from the sale of convertible senior notes and other debt, common stock, product sales and collaborative licensing and milestone revenue. As of June 30, ~~2022,~~2023, we had an accumulated deficit of ~~$138.0~~$142.5 million, cash and cash equivalents and ~~short-term~~ available-for-sale investments of ~~$316.4~~$220.8 million and working capital of ~~$393.0~~$320.4 million.

We expect that our cash and available-for-sale investments on hand will be adequate to cover our short-term liquidity needs, and that we would be able to access other sources of financing should the need arise.

In March 2020, the Coronavirus Aid, Relief and Economic Security (CARES) Act was signed into law in response to the COVID-19 pandemic. The CARES Act, among other things, allows for certain measures to increase liquidity for businesses

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such as the deferral of employer payroll taxes, a tax credit for retaining employees and other provisions. We benefited from the provision to defer the payment of certain employer payroll taxes in the amount of $2.8 million for the year ended December 31, 2020 and remitted $1.4 million in December 2021. The remaining $1.4 million is due by December 31, 2022.

Summary of Cash Flows

The following table summarizes our cash flows from operating, investing and financing activities for the periods indicated (in thousands):


		Six Months Ended June 30,					Six Months Ended June 30,
Condensed Consolidated Statements of Cash Flows Data:	Condensed Consolidated Statements of Cash Flows Data:	2022		2021		Condensed Consolidated Statements of Cash Flows Data:	2023		2022
Net cash (used in) provided by:
Net cash provided by (used in):						Net cash provided by (used in):
Operating activities	Operating activities	$	60,583	$	42,215	Operating activities	$	62,627	$	60,583
Investing activities	Investing activities	(188,858)		(52,631)		Investing activities	73,509		(188,858)
Financing activities	Financing activities	(335,242)		16,233		Financing activities	(153,465)		(335,242)
Net (decrease) increase in cash and cash equivalents		$	(463,517)	$	5,817
Net decrease in cash and cash equivalents						Net decrease in cash and cash equivalents	$	(17,329)	$	(463,517)

Operating Activities

During the six months ended June 30, ~~2022,~~2023, net cash provided by operating activities was ~~$60.6~~$62.6 million, compared to ~~$42.2~~$60.6 million during the six months ended June 30, ~~2021.~~2022. The increase of ~~$18.4~~$2.0 million was ~~primarily~~ attributable to higher revenues, increased ~~net product sales from both ZILRETTA, acquired as part~~interest income and lower interest expense, partially offset by the payment of ~~the Flexion Acquisition in November 2021,~~a $13.0 million termination fee relating to a licensing agreement and ~~EXPAREL, coupled with realized efficiencies from the acquisition of Flexion.~~lower gross margin.

Investing Activities

During the six months ended June 30, 2023, net cash provided by investing activities was $73.5 million, which reflected proceeds from $90.2 million of available-for-sale investment sales (net of purchases), partially offset by purchases of fixed assets of $10.0 million for fill lines for our products and equipment for an EXPAREL capacity expansion project at our Science Center Campus in San Diego, California and purchases of equity and debt investments of $6.8 million.

During the six months ended June 30, 2022, net cash used in investing activities was $188.9 million, which reflected $124.7 million of short-term available-for-sale investment purchases (net of maturities), a $32.0 million contingent consideration milestone payment that had been achieved in the fourth quarter of 2021 associated with our 2007 acquisition of Pacira Pharmaceuticals, Inc. from Skyepharma, purchases of fixed assets of $19.4 million for fill lines for our products and equipment for a 200-liter EXPAREL capacity expansion project at our Science Center Campus in San Diego, California and purchases of equity and debt investments of $12.8 million.

Financing Activities

During the six months ended June 30, ~~2021,~~2023, net cash used in ~~investing~~financing activities was ~~$52.6~~$153.5 million, which ~~reflected $23.8~~consisted of a $296.9 million repayment of ~~short-term~~TLB Term Loan principal as well as a $5.8 million prepayment penalty in connection with the retirement of the TLB Term Loan facility, partially offset by the net proceeds from the TLA Term Loan of $149.6 million and ~~long-term investment purchases (net~~the exercise of ~~maturities)~~stock options of $1.9 million and ~~purchases~~$1.7 million from the issuance of ~~fixed assets of $23.6 million. Major fixed asset purchases~~common stock through our ESPP. See Note 8, Debt, to our condensed consolidated financial statements included ~~equipment~~herein for a new 200-liter EXPAREL capacity expansion project at our Science Center Campus in San Diego, California, and continuing expenditures for our expanding EXPAREL manufacturing capacity in Swindon, England. In addition, we made a $10.0 million equity investment and also purchased a total of $4.2 million in convertible notes. We also sold one of our equity investments for net cash proceeds of $9.1 million.

~~Financing Activities~~further discussion.

During the six months ended June 30, 2022, net cash used in financing activities was $335.2 million, which primarily consisted of a $192.6 million principal repayment of the 3.375% convertible senior notes due 2024 (the “Flexion 2024 Notes”) as part of a repurchase offer to the holders of the Flexion 2024 Notes that was triggered by the Flexion Acquisition, a $157.0 million ~~to settle the 2022 Notes~~repayment of our 2.375% convertible senior notes that matured on April 1, 2022 and a $9.4 million scheduled

Pacira BioSciences, Inc. | Q2 2023 Form 10-Q | Page 42

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repayment of TLB Term Loan principal, partially offset by $21.9 million of proceeds from the exercise of stock options and $1.8 million from the issuance of common stock through our ESPP.

During the six months ended June 30, 2021, net cash provided by financing activities was $16.2 million, which consisted of proceeds from the exercise of stock options of $16.0 million and $1.6 million from the issuance of common stock through our ESPP, partially offset by the $1.3 million financing component of the $7.0 million contingent consideration payment made to MyoScience securityholders.

~~Pacira BioSciences, Inc. | Q2 2022 Form 10-Q | Page 45~~

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Debt

~~2026~~2028 Term Loan BA Facility

~~In December 2021,~~On March 31, 2023, we entered into a credit agreement (the “TLA Credit Agreement”) to refinance the ~~$375.0~~indebtedness outstanding under the Company’s TLB Credit Agreement (as defined and discussed below). The term loan issued under the TLA Credit Agreement (the “TLA Term Loan”) was issued at a 0.30% discount and provides for a single-advance term loan A facility in the principal amount of $150.0 million, ~~Term Loan~~ which is secured by substantially all of our and any subsidiary guarantor’s assets and ~~is scheduled to mature~~matures on ~~December 7, 2026, subject to certain exceptions set forth in the term loan credit agreement (the “Credit Agreement”).~~March 31, 2028. We may elect to borrow either (i) alternate base rate borrowings or (ii) term benchmark borrowings or daily simple SOFR (as defined in the TLA Credit Agreement) borrowings. Each term loan borrowing which is an alternate base rate borrowing bears interest at a ~~variable~~ rate per annum equal to (i) the Alternate Base Rate (as defined in the TLA Credit Agreement) ~~subject~~, plus (ii) a spread based on our Senior Secured Net Leverage Ratio ranging from 2.00% to ~~a 1.75% floor, plus 6.00%~~2.75%. Each term loan borrowing which is a term benchmark borrowing or daily simple SOFR borrowing bears interest at a ~~variable~~ rate per annum equal to (i) the Adjusted Term SOFR Rate or Adjusted Daily Simple SOFR (as each is defined in the TLA Credit Agreement) ~~subject to a 0.75% floor~~, plus (ii) ~~7.00%~~a spread based on our Senior Secured Net Leverage Ratio ranging from 3.00% to 3.75%. During the six months ended June 30, 2023, the Company made a scheduled principal payment of $2.8 million. As of June 30, 2023, borrowings under the TLA Term Loan consisted entirely of term benchmark borrowings at a rate of 8.01%. Subsequent to June 30, 2023, the Company made a $25.0 million principal prepayment in July 2023.

The TLA Credit Agreement requires us to, among other things, maintain (i) a ~~first lien net leverage ratio,~~Senior Secured Net Leverage Ratio (as defined in the Credit Agreement), determined as of the last day of ~~any~~each fiscal quarter, of no greater than ~~1.75~~3.00 to 1.00 and (ii) ~~liquidity, at any time,~~a Fixed Charge Coverage Ratio (as defined in the TLA Credit Agreement), determined as of ~~at least $150.0 million.~~the last day of each fiscal quarter, of no less than 1.50 to 1.00. The TLA Credit Agreement also contains customary affirmative and negative covenants, financial covenants, representations and warranties, events of default and other provisions. As of June 30, ~~2022,~~2023, we were in compliance with all financial covenants under the TLA Credit Agreement. See Note 8, Debt, to our condensed consolidated financial statements included herein for further discussion.

2026 Term Loan B Facility

In December 2021, we entered into the $375.0 million TLB Term Loan which was secured by substantially all of our and any subsidiary guarantor’s assets and was scheduled to mature on December 7, 2026, subject to certain exceptions set forth in the TLB Credit Agreement.

On March 31, 2023, we used the $149.6 million of net borrowings under the TLA Credit Agreement and cash on hand to repay the indebtedness outstanding under the TLB Credit Agreement and concurrently terminated the TLB Credit Agreement. We incurred a prepayment fee of 2.00% of the outstanding principal balance of the TLB Term Loan in connection with the termination. During the six months ended June 30, ~~2022,~~2023, we made a scheduled principal payment of $9.4 ~~million. At June 30, 2022, we had $365.6~~ million inand repaid the outstanding ~~borrowings under~~$287.5 million principal on the ~~Term Loan. As a result of our entry into the~~TLB Term Loan, ~~we expect our interest expense to increase~~which resulted in ~~2022.~~a $16.9 million loss on early extinguishment of debt. See Note 9,8, Debt, to our condensed consolidated financial statements included herein for further discussion.

2025 Convertible Senior Notes

In July 2020, we completed a private placement of $402.5 million in aggregate principal amount of our 0.750% convertible senior notes due 2025, or 2025 Notes, and entered into an indenture with respect to the 2025 Notes. The 2025 Notes accrue interest at a fixed rate of 0.750% per annum, payable semiannually in arrears on February 1st and August 1st of each year. The 2025 Notes mature on August 1, 2025. At June 30, ~~2022,~~2023, the outstanding principal on the 2025 Notes was $402.5 million. See Note 9,8, Debt, to our condensed consolidated financial statements included herein for further discussion.

2024 Convertible Senior Notes

In November 2021, as part of the Flexion Acquisition, we assumed $201.3 million in aggregate principal amount of the Flexion 2024 Notes. The Flexion 2024 Notes have a maturity date of May 1, 2024, are unsecured, and accrue interest at a rate of 3.375% per annum, payable semi-annually on May 1st and November 1st of each year. In January 2022, we repurchased $192.6 million aggregate principal amount of the Flexion 2024 Notes. At June 30, ~~2022,~~2023, the outstanding principal on the Flexion 2024 Notes was $8.6 million. See Note 9,8, Debt, to our condensed consolidated financial statements included herein for further discussion.

Pacira BioSciences, Inc. | Q2 2023 Form 10-Q | Page 43

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Future Capital Requirements

We believe that our existing cash and cash equivalents, available-for-sale investments and cash received from product sales will be sufficient to enable us to fund our operating expenses, capital expenditure requirements and payment of the interest and principal on our TLA Term Loan, Flexion 2024 Notes and ~~our convertible notes, and any conversions of our~~2025 Notes (collectively, the “Notes”) through the next 12 months. Our future use of operating cash and capital requirements will depend on many forward-looking factors, including, but not limited ~~to, the following:~~

•~~the costs of successfully integrating Flexion into our existing business and expanding the commercialization of ZILRETTA;~~to:

•the cost and timing of the potential ~~Flexion~~ milestone payments ~~under the CVR Agreement,~~to former Flexion stockholders, which could be up to an aggregate of ~~$425.5~~$372.3 million if certain regulatory and commercial milestones are met. ~~(See~~See Note 4,9, ~~Flexion Acquisition~~Financial Instruments, to our condensed consolidated financial statements included herein for more ~~information);~~information;

•the cost and timing of potential remaining milestone payments to former MyoScience security holders, which could be up to an aggregate of $43.0 million if certain regulatory and commercial milestones are met. See Note 9, Financial Instruments, to our condensed consolidated financial statements included herein for more information;

•the impact of ~~the COVID-19 pandemic and~~ global economic ~~conditions,~~ conditions—including the ~~amounts~~impact of inflation—on our product and ~~delays of suspended elective surgical procedures, clinical trials,~~material costs, supply chain, longer lead-times, ~~for or the~~an inability to secure a sufficient supply of ~~materials;~~materials, our operating expenses and our business strategy;

•the timing of and extent to which the holders of our ~~convertible senior notes~~Notes elect to convert their ~~notes and~~Notes, the timing of principal and interest payments on our TLA Term ~~Loan;~~

~~Pacira BioSciences, Inc. | Q2 2022 Form 10-Q | Page 46~~

~~Table of Contents~~

•Loan and the timing and impact of increases to the variable interest rate on our TLA Term Loan borrowings in accordance with the terms of the TLA Credit Agreement;

•the costs and our ability to successfully continue to expand the commercialization of EXPAREL, ZILRETTA and iovera°, including outside of the U.S.;

•the cost and timing of expanding and maintaining our manufacturing facilities, including the current EXPAREL capacity expansion project at our Science Center Campus in San Diego, California (which we expect to submit an sNDA for in the second half of 2023) and ~~a ZILRETTA~~ capital ~~project~~projects at the Thermo Fisher site in Swindon, England;

•the cost and timing of potential remaining milestone payments to MyoScience security holders, which could be up to an aggregate of $43.0 million if certain regulatory and commercial milestones are met (See Note 10, ~~Financial Instruments, to our condensed consolidated financial statements included herein for more information);~~

•the cost and timing of additional strategic investments, including additional investments under existing agreements;

•the costs related to legal and regulatory ~~issues;~~

•~~the impact of inflation on our product costs, operating expenses and business strategy;~~matters;

•the costs of performing additional clinical trials for our products, including the additional pediatric trials required by the FDA and EMA as a condition of the approval of EXPAREL;

•the costs for the development and commercialization of other product candidates;

•the costs and timing of future payments under our employee benefit plans, including but not limited to our cash long-term incentive plan and non-qualified deferred compensation plan; and

•the extent to which we acquire or invest in products, businesses and technologies.

We may require additional debt or equity financing to meet our future operating and capital requirements. We have no committed external sources of funds, and additional equity or debt financing may not be available on acceptable terms, if at all. In particular, capital market disruptions or negative economic conditions ~~especially in light of the COVID-19 pandemic,~~ may hinder our access to capital.

Critical Accounting Estimates

~~See Note 2,~~ ~~Summary of Significant Accounting Policies~~, to our condensed consolidated financial statements included herein for a discussion of recently issued accounting pronouncements and their impact or future potential impact on our financial results, if determinable. For a description of critical accounting policies that affect our significant judgments and estimates used in the preparation of our consolidated financial statements, refer to our ~~most recent~~ 2022 Annual Report. There have been no significant changes to our critical accounting policies nor any recently issued accounting pronouncements that are expected to have a material impact on ~~Form 10-K for the year ended~~our financial results since December 31, ~~2021~~.2022.

Contractual Obligations

Except for aentry into the new ~~lease~~TLA Credit Agreement and termination of the TLB Credit Agreement as described in Note 7,8, ~~Leases~~Debt, to our condensed consolidated financial statements included herein, there have been no material changes in our contractual obligations relating to our indebtedness, lease obligations and purchase obligations from those reported in our 2022 Annual ~~Report on Form 10-K for the year ended December 31, 2021.~~Report. For more information on our contractual obligations and commercial commitments, see Part II, Item 7 in our 2022 Annual Report ~~on Form 10-K for the year ended December 31, 2021~~.

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 4744

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Item 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

The primary objective of our cash equivalents and investment activities is to preserve principal while at the same time maximizing the income that we receive from our investments without significantly increasing risk. We invest in corporate bonds, commercial paper, asset-backed securities and U.S. Treasury and other government agency notes, which are reported at fair value. These securities are subject to interest rate risk and credit risk. This means that a change in prevailing interest rates may cause the fair value of the investment to fluctuate. For example, if we hold a security that was issued with a fixed interest rate at the then-prevailing rate and the interest rate later rises, we expect that the fair value of our investment will decline. A hypothetical 100 basis point increase in interest rates would have reduced the fair value of our available-for-sale securities at June 30, ~~2022~~2023 by approximately $0.6 million.

The fair values of our Notes are impacted by both the fair value of our common stock and interest rate fluctuations. As of June 30, ~~2022,~~2023, the estimated fair value of the 2025 Notes was ~~$1,038~~$926 per $1,000 principal amount. See Note 9,8, Debt, to our condensed consolidated financial statements included herein for further discussion of our Notes, which bear interest at a fixed rate. At June 30, ~~2022,~~2023, all $402.5 million of principal remains outstanding on the 2025 Notes and $8.6 million of principal remains outstanding on the Flexion 2024 Notes.

The TLB Term Loan provided for a single-advance term loan in the principal amount of $375.0 million and iswas scheduled to mature on December 7, 2026. Each term loan borrowing which iswas an alternate base rate borrowing bears interest at a variable rate per annum equal to the Alternate Base Rate (as defined in the TLB Term Loan Credit Agreement) subject to a 1.75% floor, plus 6.00%. Each term loan borrowing which iswas a term benchmark borrowing bears interest at a variable rate per annum equal to (i) the Adjusted Term SOFR rate (as defined in the TLB Term Loan Credit Agreement) subject to a 0.75% floor plus (ii) 7.00%. ~~At June 30, 2022, we had $365.6 million in~~We repaid the outstanding principal for TLB Term Loan on March 31, 2023, therefore there were no outstanding borrowings under the TLB Term ~~Loan.~~Loan as of June 30, 2023.

The TLA Term Loan provides for a single-advance term loan in the principal amount of $150.0 million and is scheduled to mature on March 31, 2028. Each term loan borrowing that is a term benchmark borrowing or daily simple SOFR borrowing bears interest at a rate per annum equal to (i) the Adjusted Term SOFR Rate or Adjusted Daily Simple SOFR (as each is defined in the TLA Credit Agreement), plus (ii) a spread based on our Senior Secured Net Leverage Ratio ranging from 3.00% to 3.75%. As of June 30, 2023, borrowings under the TLA Term Loan consisted entirely of term benchmark borrowings at a rate of 8.01%. A hypothetical 100 basis point increase in interest rates would have increased interest expense ~~during~~for both the three and six months ended June 30, ~~2022~~2023 by approximately ~~$0.9 million and $1.9 million, respectively.~~$0.4 million.

As a result of the Flexion Acquisition and as discussed in more detail in Note 9,8, Debt, to our condensed consolidated financial statements included herein, any future conversion rights for the Flexion 2024 Notes are subject to the occurrence of any future events giving rise to such conversion rights under the indenture governing the Flexion 2024 Notes.

We have agreements with certain vendors and partners that operate in foreign jurisdictions. The more significant transactions are primarily denominated in the U.S. Dollar, subject to an annual adjustment based on changes in currency exchange rates.

Additionally, our accounts receivable are primarily concentrated with four large wholesalers of pharmaceutical products. In the event of non-performance or non-payment, there may be a material adverse impact on our financial condition, results of operations or net cash flow.

~~Pacira BioSciences, Inc. | Q2 2022 Form 10-Q | Page 48~~

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Item 4. CONTROLS AND PROCEDURES

Evaluation of Disclosure Controls and Procedures

As required by Rule 13a-15(b) under the Exchange Act, our management, including our Chief Executive Officer and Chairman and our Chief Financial Officer, conducted an evaluation of the effectiveness of the design and operation of our disclosure controls and procedures as of the end of the period covered by this report. As defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act, disclosure controls and procedures are controls and other procedures which are designed to ensure that information required to be disclosed by us in the reports we file or submit under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the SEC’s rules and forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed by us in the reports we file or submit under the Exchange Act is accumulated and communicated to our management, including our Chief Executive Officer and Chairman and our Chief Financial Officer, as appropriate, to allow timely decisions regarding required disclosure.

~~In November 2021, we acquired Flexion (now~~

Pacira ~~Therapeutics,~~BioSciences, Inc.~~, or Pacira Therapeutics). As such, the scope~~ | Q2 2023 Form 10-Q | Page 45

Table of our assessment of the effectiveness of our disclosure controls and procedures did not include the internal control over financial reporting of Pacira Therapeutics. These exclusions are consistent with the SEC Staff’s guidance that an assessment of a recently acquired business may be omitted from the scope of our assessment of the effectiveness of disclosure controls and procedures that are also part of internal control over financial reporting in the 12 months following the acquisition. Assets acquired in the Flexion Acquisition (excluding goodwill, intangible assets, and their related deferred taxes which are included within the scope of the assessment) accounted for a minimal fraction of our total assets and ZILRETTA represented 16% of our total revenue as of and for each of the three and six months ended June 30, 2022.Contents

Based on that evaluation, our Chief Executive Officer and Chairman and our Chief Financial Officer concluded that our disclosure controls and procedures were effective as of June 30, ~~2022.~~2023.

Changes in Internal Control over Financial Reporting

There have been no ~~other~~ changes in our internal control over financial reporting that occurred during the quarter ended June 30, ~~2022~~2023 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

As a result of the Flexion Acquisition, we have commenced an evaluation of the Pacira Therapeutics internal control processes and procedures and have begun incorporating those processes and procedures into our internal control framework.

Inherent Limitations on Effectiveness of Controls

Our management, including the Chief Executive Officer and Chairman and our Chief Financial Officer, does not expect that our disclosure controls or our internal control over financial reporting will prevent or detect all errors and all fraud. A control system, no matter how well designed and operated, can provide only reasonable, not absolute, assurance that the control system’s objectives will be met. The design of a control system must reflect the fact that there are resource constraints, and the benefits of controls must be considered relative to their costs. Further, because of the inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that misstatements due to error or fraud will not occur or that all control issues and instances of fraud, if any, within our company have been detected. These inherent limitations include the realities that judgments in decision-making can be faulty and that breakdowns can occur because of simple errors or mistakes. Controls can also be circumvented by the individual acts of some persons, by collusion of two or more people or by management override of the controls. The design of any system of controls is based in part on certain assumptions about the likelihood of future events, and there can be no assurance that any design will succeed in achieving its stated goals under all potential future conditions. Projections of any evaluation of controls effectiveness to future periods are subject to risks. Over time, controls may become inadequate because of changes in conditions or deterioration in the degree of compliance with policies or procedures.

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 4946

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PART II — OTHER INFORMATION

Item 1. LEGAL PROCEEDINGS

For information related to Item 1. Legal Proceedings, refer to Note ~~16,~~15, Commitments and Contingencies, to our

condensed consolidated financial statements included herein.

Item 1A. RISK FACTORS

You should carefully consider the factors discussed in Part I, Item 1A. “Risk Factors” in our 2022 Annual Report ~~on Form 10-K for the year ended December 31, 2021~~, which could materially affect our business, financial condition, cash flows or future results. There have been no material changes in our risk factors included in our 2022 Annual ~~Report on Form 10-K for the year ended December 31, 2021.~~Report. The risks described in our 2022 Annual Report ~~on Form 10-K for the year ended December 31, 2021~~ are not the only risks facing our Company. Additional risks and uncertainties not currently known to us or that we currently deem to be immaterial also may materially adversely affect our business, financial condition or future results.

Item 2. UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS

None.

Item 3. DEFAULTS UPON SENIOR SECURITIES

None.

Item 4. MINE SAFETY DISCLOSURES

Not applicable.

Item 5. OTHER INFORMATION

Rule 10b5-1 Trading Plans

The following table shows the “Rule 10b5-1 trading arrangements” and “non-Rule 10b5-1 trading arrangements” (as each term is defined in Item 408(a) of Regulation S-K) adopted or terminated by our directors and executive officers during the quarter ended June 30, 2023:

Trading Arrangement

Name and Position

Action

Date

Rule 10b5-1*

Non-Rule
10b5-1**

Total Number of
Shares to be Sold

Expiration Date

Gary Pace

Director

Adopt

6/16/2023

8,000

6/3/2024

Gary Pace

Director

Terminate (1)

5/11/2023

7,000

5/11/2023

* Intended to satisfy the affirmative defense of Rule 10b5-1(c).

** Not intended to satisfy the affirmative defense of Rule 10b5-1(c).

~~Not applicable.~~(1) Trading arrangement was originally adopted on June 13, 2022.

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 5047

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Item 6. EXHIBITS

The exhibits listed below are filed or furnished as part of this report.


Exhibit Number						Description
10.1						Amended and Restated ~~2014 Employee~~2011 Stock ~~Purchase~~Incentive Plan.(1)†

10.2						Side Letter dated June 5, 2023, to the Manufacturing and Supply Agreement by and between the Registrant and Patheon UK Limited.††

31.1						Certification of Chief Executive Officer and Chairman pursuant to Rule 13a-14(a) and 15d-14(a), as amended.*

31.2						Certification of Chief Financial Officer pursuant to Rule 13a-14(a) and 15d-14(a), as amended.*

32.1						Certification of Chief Executive Officer and Chairman and Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.**

101						The following materials from the Quarterly Report on Form 10-Q of Pacira BioSciences, Inc. for the quarter ended June 30, ~~2022,~~2023, formatted in iXBRL (Inline eXtensible Business Reporting Language): (i) the Condensed Consolidated Balance Sheets; (ii) the Condensed Consolidated Statements of Operations; (iii) the Condensed Consolidated Statements of Comprehensive Income; (iv) the Condensed Consolidated Statements of Stockholders’ Equity; (v) the Condensed Consolidated Statements of Cash Flows; and (vi) the Condensed Notes to Consolidated Financial Statements.*

104						Cover Page Interactive Data File (Formatted as Inline XBRL and contained in Exhibit 101).


*						Filed herewith.

**						Furnished herewith.

†						Denotes management contract or compensatory plan or arrangement.

††						Certain portions of the exhibit have been omitted pursuant to Rule 601(b)(10) of Regulation S-K. The omitted information is (i) not material and (ii) would cause competitive harm to the Company if publicly disclosed.

(1)						Incorporated by reference to the Registrant’s Current Report on Form 8-K, filed on June ~~10, 2022.~~20, 2023.

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 5148

Table of Contents

~~SIGNATURES~~


SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

PACIRA BIOSCIENCES, INC.
(REGISTRANT)

~~Dated:~~Date:

August ~~3, 2022~~2, 2023

By:

/s/ DAVID STACK

David Stack

Chief Executive Officer and Chairman

(Principal Executive Officer)

~~Dated:~~Date:

August ~~3, 2022~~2, 2023

By:

/s/ CHARLES A. REINHART, III

Charles A. Reinhart, III

Chief Financial Officer

(Principal Financial Officer)

Pacira BioSciences, Inc. | Q2 ~~2022~~2023 Form 10-Q | Page 5249


	Amounts Recognized at the Acquisition Date (as previously reported) (a)		Measurement Period Adjustments (b)		Amounts Recognized at the Acquisition Date (as adjusted)
ASSETS ACQUIRED
Cash and cash equivalents	$	113,562	$	—	$	113,562
Short-term available-for-sale investments	11,153		—		11,153
Accounts receivable	32,838		—		32,838
Inventories	29,667		—		29,667
Prepaid expenses and other assets	4,852		—		4,852
Fixed assets	23,307		—		23,307
Deferred tax assets	58,015		—		58,015
Right-of-use assets	6,585		—		6,585
Identifiable intangible assets	480,000		—		480,000
In-process research and development (IPR&D)	61,000		—		61,000
Total assets	$	820,979	$	—	$	820,979
LIABILITIES ASSUMED
Accounts payable	$	9,794	$	—	$	9,794
Accrued expenses	22,746		957		23,703
Deferred revenue	10,000		—		10,000
Lease liabilities	6,585		—		6,585
Other liabilities	1,187		—		1,187
Long-term debt	201,450		—		201,450
Total liabilities	251,762		957		252,719
Total identifiable net assets acquired	569,217		(957)		568,260
Goodwill	9,628		957		10,585
Total consideration transferred	$	578,845	$	—	$	578,845


	Three Months Ended June 30, 2021		Six Months Ended June 30, 2021
Total revenues	$	163,765	$	307,381
Net loss	$	(3,367)	$	(20,487)
Pro forma basic and diluted net loss per share	$	(0.08)	$	(0.47)


June 30, 2021	Returns Allowances		Prompt Payment Discounts		Service Fees		Volume Rebates and Chargebacks		Government Rebates		Total
Balance at December 31, 2020	$	1,023	$	1,007	$	1,168	$	1,600	$	—	$	4,798
Provision	498		5,050		3,806		6,238		—		15,592
Payments / Adjustments	(261)		(4,631)		(3,846)		(5,814)		—		(14,552)
Balance at June 30, 2021	$	1,260	$	1,426	$	1,128	$	2,024	$	—	$	5,838