Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒

Indicate the number of shares outstanding of each of the issuer’s classes of common stock, as of the latest practicable date.

This Quarterly Report on Form 10-Q contains forward‑looking statements relating to future events and our future performance within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Stockholders are cautioned that such statements involve risks and uncertainties, including: weWe may not be able to successfully market Ampyra, Inbrija or any other products under development; the COVID-19 pandemic, including related ~~quarantines~~restrictions on in-person interactions and travel, ~~restrictions,~~ and the potential for ~~the~~ illness, quarantines, and vaccine mandates to affect our management, employees or consultants or those that work for other companies we rely upon, could have a material adverse effect on our business operations or product sales; our ability to attract and retain key management and other personnel, or maintain access to expert advisors; our ability to raise additional funds to finance our operations, repay outstanding indebtedness or satisfy other obligations, and our ability to control our costs or reduce planned ~~expenditures~~expenditures; risks associated with the trading of our common stock and ~~take other actions which are necessary~~our reverse stock split; risks related to our corporate restructurings, including our ability to outsource certain operations, realize expected cost savings and maintain the workforce needed for ~~us to continue as a going concern;~~continued operations; risks associated with complex, regulated manufacturing processes for pharmaceuticals, which could affect whether we have sufficient commercial supply of Inbrija to meet market demand; ~~third party~~our reliance on third-party manufacturers for the production of commercial supplies of Ampyra and Inbrija; third-party payers (including governmental agencies) may not reimburse for the use of Inbrija ~~or our other products~~ at acceptable rates or at all and may impose restrictive prior authorization requirements that limit or block prescriptions; reliance on collaborators and distributors to commercialize Inbrija and Ampyra outside the U.S.; competition for Inbrija ~~Ampyra~~ and ~~other products we may develop and market in the future,~~Ampyra, including increasing competition and accompanying loss of revenues in the U.S. from generic versions of Ampyra ~~(dalfampridine)~~ following our loss of patent exclusivity; the ability to realize the benefits anticipated from acquisitions, among other reasons because acquired development programs are generally subject to all the risks inherent in the drug development process and our knowledge of the risks specifically relevant to acquired programs generally improves over time; the risk of unfavorable results from future studies of Inbrija ~~(levodopa inhalation powder)~~ or from ~~our~~ other research and development programs, or any other acquired or in-licensed programs; the occurrence of adverse safety events with our products; the outcome (by judgment or settlement) and costs of legal, administrative or regulatory proceedings, investigations or inspections, including, without limitation, collective, representative or class action litigation; failure to protect our intellectual property, to defend against the intellectual property claims of others or to obtain third party intellectual property licenses needed for the commercialization of our products; and failure to comply with regulatory requirements could result in adverse action by regulatory agencies. These forward-looking statements are based on current expectations, estimates, forecasts and projections about the industry and markets in which we operate and management’s beliefs and assumptions. All statements, other than statements of historical facts, included in this report regarding our strategy, future operations, future financial position, future revenues, projected costs, prospects, plans and objectives of management are forward-looking statements. The words “anticipates,” “believes,” “estimates,” “expects,” “intends,” “may,” “plans,” “projects,” “will,” “would,” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements we make, and investors should not place undue reliance on these statements. In addition to the risks and uncertainties described above, we have included important factors in the cautionary statements included in this report and in our Annual Report on Form 10-K for the year ended December 31, ~~2019,~~2020, particularly in the “Risk Factors” section (as updated by the disclosures in our subsequent quarterly reports, including this report), that we believe could cause actual results or events to differ materially from the forward-looking statements that we make. Our forward-looking statements do not reflect the potential impact of any future acquisitions, mergers, dispositions, joint ventures or investments that we may make. Forward-looking statements in this report are made only as of the date hereof, and we do not assume any obligation to publicly update any forward-looking statements as a result of developments occurring after the date of this report.

We and our subsidiaries own several registered trademarks in the U.S. and in other countries. These registered trademarks include, in the U.S., the marks “Acorda Therapeutics,” our stylized Acorda Therapeutics logo, “Biotie Therapies,” “Ampyra,” “Inbrija,” and “ARCUS.” Also, our marks “Fampyra” and “Inbrija” are registered marks in the European Community Trademark Office and we have registrations or pending applications for these marks in other jurisdictions. Our trademark portfolio also includes several registered trademarks and pending trademark applications in the U.S. and worldwide for potential product names or for disease awareness activities. Third party trademarks, trade names, and service marks used in this report are the property of their respective owners.

(In thousands, except share data)	September 30, 2020			December 31, 2019			September 30, 2021			December 31, 2020
	(unaudited)						(unaudited)
Assets
Current assets:
Cash and cash equivalents	$	57,910		$	62,085		$	36,168		$	71,369
Restricted cash		13,200			12,836			13,353			12,917
Short term investments		5,347			63,754
Trade accounts receivable, net of allowances of $635 and $682, as of September 30, 2020 and December 31, 2019, respectively		13,385			22,083
Trade accounts receivable, net of allowances of $1,245 and $1,266, as of September 30, 2021 and December 31, 2020, respectively								13,587			20,193
Prepaid expenses		15,382			11,574			11,192			14,807
Inventory, net		30,120			25,221			20,595			28,677
Assets held for sale								—			71,795
Other current assets		16,470			3,560			2,174			1,577
Total current assets		151,814			201,113			97,069			221,335
Property and equipment, net of accumulated depreciation		139,255			142,527			5,016			7,263
Intangible assets, net of accumulated amortization		374,743			402,329			343,731			366,981
Right of use asset, net of accumulated amortization		19,805			23,450			7,861			18,481
Restricted cash		24,819			30,270			12,399			18,609
Other assets		11			29			11			11
Total assets	$	710,447		$	799,718		$	466,087		$	632,680
Liabilities and Stockholders’ Equity
Current liabilities:
Accounts payable	$	10,361		$	26,257		$	15,500		$	12,155
Accrued expenses and other current liabilities		41,430			39,077			34,158			38,167
Current portion of loans payable		68,050			603			—			68,631
Current portion of liability related to sale of future royalties		8,624			10,836			7,452			8,731
Current portion of lease liabilities		7,893			7,746			9,316			7,944
Current portion of acquired contingent consideration		2,391			1,866			1,845			1,624
Total current liabilities		138,749			86,385			68,271			137,252
Convertible senior notes		134,622			192,774			147,447			137,619
Derivative liability		832			59,409			325			1,193
Non-current portion of acquired contingent consideration		43,709			78,434			41,155			46,576
Non-current portion of lease liabilities		18,747			22,996			4,287			17,200
Non-current portion of loans payable		26,978			25,495			27,929			28,555
Deferred tax liability		23,120			9,581			11,912			19,116
Non-current portion of liability related to sale of future royalties		9,147			13,565			—			6,526
Other non-current liabilities		1,012			259			286			688
Commitments and contingencies
Stockholders’ equity:
Preferred stock, $0.001 par value. Authorized 1,000,000 shares at September 30, 2020 and December 31, 2019; 0 shares issued as of September 30, 2020 and December 31, 2019, respectively		—			—
Common stock, $0.001 par value. Authorized 370,000,000 shares at September 30, 2020 and 80,000,000 at December 31, 2019; issued 47,734,146 and 47,730,396 shares, including those held in treasury, as of September 30, 2020 and December 31, 2019, respectively		48			48
Treasury stock at cost (29,304 shares at September 30, 2020 and December 31, 2019)		(638	)		(638	)
Preferred stock, $0.001 par value. Authorized 1,000,000 shares at September 30, 2021 and December 31, 2020; 0 shares issued as of September 30, 2021 and December 31, 2020, respectively								—			—
Common stock, $0.001 par value. Authorized 61,666,666 shares at September 30, 2021 and December 31, 2020; issued 11,193,741 and 9,475,631 shares, including those held in treasury, as of September 30, 2021 and December 31, 2020, respectively								11			9
Treasury stock at cost (5,543 shares at September 30, 2021 and December 31, 2020)								(638	)		(638	)
Additional paid-in capital		999,762			979,388			1,016,448			1,007,790
Accumulated deficit		(683,355	)		(666,809	)		(849,789	)		(766,403	)
Accumulated other comprehensive (loss) income		(2,286	)		(1,169	)
Accumulated other comprehensive loss								(1,557	)		(2,803	)
Total stockholders’ equity		313,531			310,820			164,475			237,955
Total liabilities and stockholders’ equity	$	710,447		$	799,718		$	466,087		$	632,680

(In thousands, except per share data)	Three-month period ended September 30, 2020			Three-month period ended September 30, 2019			Nine-month period ended September 30, 2020			Nine-month period ended September 30, 2019			Three-month period ended September 30, 2021			Three-month period ended September 30, 2020			Nine-month period ended September 30, 2021			Nine-month period ended September 30, 2020
Revenues:
Net product revenues	$	34,687		$	44,800		$	90,153		$	133,325		$	27,851		$	34,687		$	81,297		$	90,153
Milestone revenues		15,000			—			15,000			—			—			15,000			—			15,000
Royalty revenues		3,403			2,922			9,654			8,586			3,605			3,403			10,807			9,654
Total net revenues		53,090			47,722			114,807			141,911			31,456			53,090			92,104			114,807
Costs and expenses:
Cost of sales		12,170			7,986			22,670			26,183			13,303			12,170			36,589			22,670
Research and development		5,729			16,073			18,689			51,060			1,931			5,729			9,054			18,689
Selling, general and administrative		39,935			48,702			119,700			151,622			29,623			39,935			95,959			119,700
Amortization of intangible assets		7,691			7,692			23,073			17,945			7,691			7,691			23,073			23,073
Asset impairment		—			277,561			4,131			277,561			—			—			—			4,131
Change in fair value of derivative liability		(4,864	)		—			(40,320	)		—			(288	)		(4,864	)		(868	)		(40,320	)
Changes in fair value of acquired contingent consideration		(23,608	)		(50,942	)		(33,455	)		(56,342	)		2,205			(23,608	)		(4,224	)		(33,455	)
Total operating expenses		37,053			307,072			114,488			468,029			54,465			37,053			159,583			114,488
Operating income (loss)		16,037			(259,350	)		319			(326,118	)
Operating loss														(23,009	)		16,037			(67,479	)		319
Other income (expense), net:
Interest and amortization of debt discount expense		(7,760	)		(4,500	)		(22,810	)		(16,302	)		(7,167	)		(7,760	)		(22,697	)		(22,810	)
Interest income		317			333			807			3,327			1			317			4			807
Other income (expense)		19			—			(16	)		—			—			19			1			(16	)
Gain on disposal of property and equipment		200			—			200			—			—			200			—			200
Realized loss on foreign currency transactions		(1	)		(1	)		(8	)		(17	)		(1	)		(1	)		(4	)		(8	)
Total other expense, net		(7,225	)		(4,168	)		(21,827	)		(12,992	)		(7,167	)		(7,225	)		(22,696	)		(21,827	)
Income (loss) before taxes		8,812			(263,518	)		(21,508	)		(339,110	)		(30,176	)		8,812			(90,175	)		(21,508	)
Benefit from (Provision for) income taxes		(1,465	)		(17	)		4,962			484			3,105			(1,465	)		6,788			4,962
Net income (loss)	$	7,347		$	(263,535	)	$	(16,546	)	$	(338,626	)	$	(27,071	)	$	7,347		$	(83,387	)	$	(16,546	)

Net income (loss) per share—basic	$	0.15		$	(5.55	)	$	(0.35	)	$	(7.13	)	$	(2.43	)	$	0.92		$	(8.17	)	$	(2.08	)
Net income (loss) per share—diluted	$	0.05		$	(5.55	)	$	(0.35	)	$	(7.13	)	$	(2.43	)	$	0.32		$	(8.17	)	$	(2.08	)
Weighted average common shares outstanding used in computing net income (loss) per share—basic		47,705			47,511			47,704			47,491
Weighted average common shares outstanding used in computing net income (loss) per share—diluted		166,145			47,511			47,704			47,491
Weighted average common shares outstanding used in computing net loss per share—basic														11,131			7,960			10,204			7,960
Weighted average common shares outstanding used in computing net loss per share—diluted														11,131			27,700			10,204			7,960

	Common stock																		Common stock
(In thousands)	Number of shares		Par value		Treasury stock			Additional paid-in capital		Accumulated deficit			Accumulated other comprehensive (loss) income			Total stockholders equity			Number of shares		Par value		Treasury stock			Additional paid-in capital		Accumulated deficit			Accumulated other comprehensive (loss) income			Total stockholders equity
Balance at December 31, 2019		47,730	$	48	$	(638	)	$	979,388	$	(666,809	)	$	(1,169	)	$	310,820
Balance at December 31, 2020																				9,476	$	9	$	(638	)	$	1,007,790	$	(766,403	)	$	(2,803	)	$	237,955
Compensation expense for issuance of stock options to employees		—		—		—			1,976		—			—			1,976			—		—		—			483		—			—			483
Compensation expense for issuance of restricted stock to employees		4		—		—			—		—			—			—			—		—		—			224		—			—			224
Exercise of stock options		—		—		—			—		—			—			—
Purchase of Treasury Stock		—		—		—			—		—			—			—
Other comprehensive income, net of tax		—		—		—			—		—			350			350			—		—		—			—		—			1,069			1,069
Net loss		—		—		—			—		(6,472	)		—			(6,472	)		—		—		—			—		(33,451	)		—			(33,451	)
Balance at March 31, 2020		47,734	$	48	$	(638	)	$	981,364		(673,281	)	$	(819	)	$	306,674
Balance at March 31, 2021																				9,476	$	9	$	(638	)	$	1,008,497		(799,854	)	$	(1,734	)	$	206,279
Compensation expense for issuance of stock options to employees		—		—		—			2,056		—			—			2,056			—		—		—			498		—			—			498
Compensation expense for issuance of restricted stock to employees		—		—		—			—		—			—			—			—		—		—			456		—			—			456
Adjustments to Treasury Stock		—		—		—			—		—			—			—
Purchase of Treasury Stock		—		—		—			—		—			—			—
Other comprehensive (loss) income, net of tax		—		—		—			—		—			(404	)		(404	)
Interest payment for convertible notes																				1,636		2		—			6,208		—			—			6,210
Other comprehensive loss, net of tax																				—		—		—			—		—			(99	)		(99	)
Net loss		—		—		—			—		(17,421	)		—			(17,421	)		—		—		—			—		(22,864	)		—			(22,864	)
Balance at June 30, 2020		47,734	$	48	$	(638	)	$	983,420	$	(690,702	)	$	(1,223	)	$	290,905
Balance at June 30, 2021																				11,112	$	11	$	(638	)	$	1,015,659	$	(822,718	)	$	(1,833	)	$	190,481
Compensation expense for issuance of stock options to employees		—		—		—			2,480		—			—			2,480			—		—		—			455		—			—			455
Compensation expense for issuance of restricted stock to employees		—		—		—			—		—			—			—
Reclassification of derivative liability to equity, net of tax of $4.4 million		—		—		—			13,862		—			—			13,862
Compensation expense and issuance of restricted stock to employees																				82		—		—			334		—			—			334
Other comprehensive (loss) income, net of tax		—		—		—			—		—			(1,063	)		(1,063	)		—		—		—			—		—			276			276
Net income (loss)		—		—		—			—		7,347			—			7,347			—		—		—			—		(27,071	)		—			(27,071	)
Balance at September 30, 2020		47,734	$	48	$	(638	)	$	999,762	$	(683,355	)	$	(2,286	)	$	313,531
Balance at September 30, 2021																				11,194	$	11	$	(638	)	$	1,016,448	$	(849,789	)	$	(1,557	)	$	164,475

Common stock

(In thousands)

Number
of
shares

Par
value

Treasury stock

Additional
paid-in
capital

Accumulated
deficit

Accumulated
other
comprehensive (loss)
income

Total
stockholders
equity

Balance at December 31, 2018

47,508

$
48

$
(2,133
)

$
1,005,105

$
(393,843
)

$
2,806

$
611,983

Compensation expense for
   issuance of stock options
   to employees

—

—

—

2,745

—

—

2,745

Compensation expense for
   issuance of restricted
   stock to employees

49

—

—

922

—

—

922

Exercise of stock options

2

—

24

—

—

24

Purchase of Treasury Stock

4

—

(52
)

—

—

—

(52
)
Other comprehensive (loss) income,
   net of tax

—

—

—

—

—

(1,431
)

(1,431
)
Net loss

—

—

—

—

(47,605
)

—

(47,605
)
Balance at March 31, 2019

47,563

$
48

$
(2,185
)

$
1,008,796

$
(441,448
)

$
1,375

$
566,586

Compensation expense for
   issuance of stock options
   to employees

—

—

—

3,180

—

—

3,180

Compensation expense for
   issuance of restricted
   stock to employees

34

—

—

1,354

—

—

1,354

Adjustments to Treasury Stock

(65
)

—

1,586

(1,586
)

—

—

—

Purchase of Treasury Stock

3

—

(39
)

—

—

—

(39
)
Other comprehensive (loss) income, net of tax

—

—

—

—

—

1,242

1,242

Net income

—

—

—

—

(27,486
)

—

(27,486
)
Balance at June 30, 2019

47,535

$
48

$
(638
)

$
1,011,744

$
(468,934
)

$
2,617

$
544,837

Compensation expense for
   issuance of stock options
   to employees

—

—

—

2,057

—

—

2,057

Compensation expense for
   issuance of restricted
   stock to employees

5

—

—

1,236

—

—

1,236

Other comprehensive (loss) income, net of tax

—

—

—

—

—

(3,253
)

(3,253
)
Net loss

—

—

—

—

(263,535
)

—

(263,535
)
Balance at September 30, 2019

47,540

$
48

$
(638
)

$
1,015,037

$
(732,469
)

$
(636
)

$
281,342

	Common stock
(In thousands)	Number of shares		Par value		Treasury stock			Additional paid-in capital		Accumulated deficit			Accumulated other comprehensive (loss) income			Total stockholders equity
Balance at December 31, 2019		7,964	$	8	$	(638	)	$	979,428	$	(666,809	)	$	(1,169	)	$	310,820
Compensation expense for issuance of stock options to employees		—		—		—			1,976		—			—			1,976
Compensation expense for issuance of restricted stock to employees		1		��		—			—		—			—			—
Other comprehensive income, net of tax		—		—		—			—		—			350			350
Net loss		—		—		—			—		(6,472	)		—			(6,472	)
Balance at March 31, 2020		7,965	$	8	$	(638	)	$	981,404	$	(673,281	)	$	(819	)	$	306,674
Compensation expense for issuance of stock options to employees		—		—		—			2,056		—			—			2,056
Other comprehensive loss, net of tax		—		—		—			—		—			(404	)		(404	)
Net loss		—		—		—			—		(17,421	)		—			(17,421	)
Balance at June 30, 2020		7,965		8		(638	)		983,460		(690,702	)		(1,223	)		290,905
Compensation expense for issuance of stock options to employees		—		—		—			2,480		—			—			2,480
Compensation expense for issuance of restricted stock to employees		—		—		—			—		—			—			—
Reclassification of derivative liability to equity, net of tax of $4.4 million		—		—		—			13,862		—			—			13,862
Other comprehensive (loss) income, net of tax		—		—		—			—		—			(1,063	)		(1,063	)
Net income (loss)		—		—		—			—		7,347			—			7,347
Balance at September 30, 2020		7,965	$	8	$	(638	)	$	999,802	$	(683,355	)	$	(2,286	)	$	313,531

(In thousands)	Nine-month period ended September 30, 2020			Nine-month period ended September 30, 2019			Nine-month period ended September 30, 2021			Nine-month period ended September 30, 2020
Cash flows from operating activities:
Net loss	$	(16,546	)	$	(338,626	)	$	(83,387	)	$	(16,546	)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:
Share-based compensation expense		6,512			11,494			2,515			6,512
Amortization of net premiums and discounts on investments		(28	)		(1,325	)		—			(28	)
Amortization of debt discount and debt issuance costs		12,219			12,202			12,672			12,219
Depreciation and amortization expense		30,919			24,697			25,482			30,919
Asset impairment		4,131			277,561			—			4,131
Change in acquired contingent consideration obligation		(33,455	)		(56,342	)		(4,224	)		(33,455	)
Non-cash royalty revenue		(8,496	)		(7,556	)		(8,889	)		(8,496	)
Deferred tax provision (benefit)		8,801			(3,667	)
Deferred tax (benefit) provision								(6,788	)		8,801
Change in derivative liability		(40,320	)		—			(868	)		(40,320	)
Gain on disposal of property and equipment		(200	)		—			—			(200	)
Changes in assets and liabilities:
Decrease in accounts receivable		8,698			5,877			6,606			8,698
(Increase) decrease in prepaid expenses and other current assets		(16,712	)		13,725
(Increase) decrease in inventory		(4,899	)		1,619
Decrease (increase) in prepaid expenses and other current assets								2,629			(16,712	)
Decrease (increase) in inventory								5,813			(4,899	)
Decrease in other assets		17			—			—			17
Decrease in accounts payable, accrued expenses and other current liabilities		(13,391	)		(56,141	)
Increase (decrease) in accounts payable, accrued expenses and other current liabilities								4,875			(13,391	)
Increase (decrease) in other non-current liabilities		296			(256	)		(1,024	)		296
Net cash used in operating activities		(62,454	)		(116,738	)		(44,588	)		(62,454	)
Cash flows from investing activities:
Purchases of property and equipment		(4,074	)		(76,414	)		(164	)		(4,074	)
Purchases of investments		—			(171,431	)
Purchases of intangible assets								(26	)		—
Proceeds from maturities of investments		58,415			191,342			—			58,415
Net cash provided by (used in) investing activities		54,341			(56,503	)
Net cash (used in) provided by investing activities								(190	)		54,341
Cash flows from financing activities:
Repayment of Convertible Senior Notes Due 2021								(69,000	)		—
Debt issuance costs		(1,071	)		—			—			(1,071	)
Proceeds from issuance of common stock and option exercises		—			24
Purchase of treasury stock		—			(91	)
Proceeds from sale of Chelsea facility, net								73,969			—
Repayment of loans payable		(597	)		(614	)		(655	)		(597	)
Net cash used in financing activities		(1,668	)		(681	)
Net cash provided by (used in) financing activities								4,314			(1,668	)
Effect of exchange rate changes on cash, cash equivalents and restricted cash		519			(265	)		(511	)		519
Net decrease in cash, cash equivalents and restricted cash		(9,262	)		(174,187	)		(40,975	)		(9,262	)
Cash, cash equivalents and restricted cash at beginning of period		105,192			294,351			102,895			105,192
Cash, cash equivalents and restricted cash at end of period	$	95,930		$	120,164		$	61,920		$	95,930
Supplemental disclosure:
Cash paid for interest	$	6,067		$	3,037		$	6		$	6,067
Cash paid for taxes		250			2,562			46			250

Acorda Therapeutics, Inc. (“Acorda” or the “Company”) is a biopharmaceutical company focused on developing therapies that restore function and improve the lives of people with neurological disorders.

The accompanying unaudited consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States (GAAP) for interim financial information, Accounting Standards Codification (ASC) Topic 270-10 and with the instructions to Form 10-Q. Accordingly, these financial statements do not include all of the information and footnotes required by GAAP for complete financial statements. In management’s opinion, all adjustments considered necessary for a fair presentation have been included in the interim periods presented and all adjustments are of a normal recurring nature. The Company has evaluated subsequent events through the date of this filing. Operating results for the three and nine-month periods ended September 30, ~~2020~~2021 are not necessarily indicative of the results that may be expected for the year ending December 31, ~~2020.~~2021. When used in these notes, the terms “Acorda” or “the Company” mean Acorda Therapeutics, Inc. The December 31, ~~2019~~2020 consolidated balance sheet data was derived from audited financial statements, but does not include all disclosures required by GAAP. You should read these unaudited interim condensed consolidated financial statements in conjunction with the consolidated financial statements and footnotes included in the Company's Annual Report on Form 10-K, for the year ended December 31, ~~2019.~~2020.

Our significant accounting policies are detailed in our Annual Report on Form 10-K for the year ended December 31, ~~2019.~~2020. Effective January 1, ~~2020,~~2021, the Company adopted ASU ~~2016-13, “Financial Instruments – Credit Losses” (Topic 326), ASU 2018-13,~~ ~~“Fair Value Measurement (Topic 820), ASU 2018-15,~~ ~~“Customer’s~~2019-12, “Simplifying the Accounting for ~~Implementation Costs Incurred in a Cloud Computing Arrangement That is a Service Contract”, and,~~ ~~ASU 2018-18,“Collaborative Arrangements”~~Income Taxes” (Topic ~~808)~~740). Other than the adoption of the new accounting guidance, our significant accounting policies have not changed materially from December 31, ~~2019.~~2020.

On December 31, 2020, we filed an amendment to our Certificate of Incorporation which effected, as of 4:01 p.m. Eastern Time on December 31, 2020, a 1-for-6 reverse stock split of the shares of our outstanding common stock and proportionate reduction in the number of authorized shares of our common stock from 370,000,000 to 61,666,666. Our common stock began trading on a split-adjusted basis on The Nasdaq Global Select Market commencing upon market open on January 4, 2021. The common stock continued to trade under the symbol “ACOR” after the reverse stock split became effective. The reverse stock split applied equally to all outstanding shares of the common stock and did not modify the rights or preferences of the common stock. As such, all figures in this report relating to shares of our common stock (such as share amounts, per share amounts, and conversion rates and prices), including in the financial statements and accompanying notes to the financial statements, have been retroactively restated to reflect the 1-for-6 reverse stock split of our common stock.

The following table provides a reconciliation of cash, cash equivalents, and restricted cash reported within the statement of financial position that sum to the total of the same amounts shown in the statement of cash flows:

Restricted cash ~~represent those amounts in~~represents an escrow ~~related~~account with funds to maintain the ~~6% semi-annual~~ interest ~~portion~~payments for an amount equal to all remaining scheduled interest payments on the outstanding convertible senior secured notes due 2024 through the interest payment date of ~~the convertible note exchange completed in December 2019 payable within the next 12 months~~June 1, 2023; and ~~those amounts required to be set aside~~a bank account with funds to cover the Company’s self-funded employee health ~~insurance costs over~~insurance. At September 30, 2021, the ~~next 12 months. Restricted~~Company also held $0.3 million of restricted cash ~~non-current represents those amounts in escrow~~ related to ~~the 6% semi-annual interest portion of the convertible note exchange completed in December 2019 payable subsequent to the next twelve months and~~ cash collateralized standby letters of credit in connection with obligations under facility leases and $12.1 million related to the escrow account for interest payments included in restricted cash non-current in the consolidated balance sheet due to the long-term nature of the letters of ~~credit.~~ ~~The 6% semi-annual~~credit and interest ~~portion of the convertible notes is payable in cash or, if permitted by the terms of the notes, stock.~~payments. (see Note 10).

The Company reviews inventory, including inventory purchase commitments, for slow moving or obsolete amounts based on expected product sales volume and provides reserves against the carrying amount of inventory as appropriate.On February 10, 2021, we completed the sale of our Chelsea, Massachusetts manufacturing operations to Catalent Pharma Solutions. In connection with the sale of the manufacturing operations, we transferred approximately $2.3 million of raw materials to Catalent (see Note 12). Additionally, in reviewing the inventory for slow moving or obsolete amounts we recorded a charge of $1.3 million for the remaining work-in-progress inventory that was scrapped or discarded during the nine-month period ended September 30, 2021.

The functional currency of operations outside the United States of America is deemed to be the currency of the local country, unless otherwise determined that the United States dollar would serve as a more appropriate functional currency given the economic operations of the entity. Accordingly, the assets and liabilities of the Company’s foreign subsidiary, Biotie, are translated into United States dollars using the period-end exchange rate; income and expense items are translated using the average exchange rate during the period; and equity transactions are translated at historical rates. Cumulative translation adjustments are reflected as a separate component of equity. Foreign currency transaction losses and gains are recognized in the period incurred and are reported as other (expense) income, net in the statement of operations.

The Company is managed and operated as 1 business which is focused on developing therapies that restore function and improve the lives of people with neurological disorders. The entire business is managed by a single management team that reports to the Chief Executive Officer, who is the chief operating decision maker. The Company does not operate separate lines of business with respect to any of its products or product candidates and the Company does not prepare discrete financial information with respect to separate products or product candidates or by location. Accordingly, the Company views its business as 1 reportable operating segment. Net product revenues reported are derived from the sales of Inbrija and Ampyra in the U.S. for the three and nine-month periods ended September 30, ~~2020~~2021 and ~~2019.~~2020.

The Company continually evaluates whether events or circumstances have occurred that indicate that the estimated remaining useful lives of its long-lived assets, including identifiable intangible assets ~~subject to amortization and indefinite lived intangible assets not~~ subject to amortization and property plant and equipment, may warrant revision or that the carrying value of the assets may be impaired. Factors the Company considers important that could trigger an impairment review include significant changes in the use of any assets, changes in historical trends in operating performance, changes in projected operating performance, results of clinical trials, stock price,

loss of a major customer and significant negative economic trends. ~~Based on~~The decline in the trading price of the Company’s ~~evaluation~~common stock during the quarter ended June 30, 2021, and related decrease in the Company’s market capitalization, was determined to be a triggering event in connection with the Company’s review of the recoverability of its long-lived assets for the three-month period ended ~~March 31, 2020,~~June 30, 2021. The Company performed a recoverability test as of June 30, 2021 using the undiscounted cash flows, which are the sum of the future undiscounted cash flows expected to be derived from the direct use of the long-lived assets to the carrying value of the long-lived assets. Estimates of future cash flows were based on the Company’s own assumptions about its own use of the long-lived assets. The cash flow estimation period was based on the long-lived assets’ estimated remaining useful life to the Company. After performing the recoverability test, the Company determined that ~~its indefinite lived intangible asset BTT1023 was fully impaired~~the undiscounted cash flows exceeded the carrying value and ~~recorded an asset impairment in its consolidated statement of operations. The Company also determined that its finite lived intangible~~the long-lived assets were not ~~impaired~~impaired. Changes in these assumptions and resulting valuations or further declines in our stock price could result in future long-lived asset impairment charges. Management will continue to monitor any changes in circumstances for indicators of impairment. Any write-downs are treated as permanent reductions in the ~~three and nine-month periods ended September 30, 2020.~~carrying amount of the assets.

The ~~Company assesses and determines its ability to continue as a going concern in accordance with the provisions of ASC Topic 205-40, “Presentation of Financials Statements—Going~~ Concern” (“ASC Topic 205-40”), which requires the Company to evaluate whether there are conditions or events that raise substantial doubt about its ability to continue as a going concern within one year after the date that its annual and interim consolidated financial statements are issued. Certain additional financial statement disclosures are required if such conditions or events are identified. If and when an entity’s liquidation becomes imminent, financial statements should be prepared under the liquidation basis of accounting. Determining the extent, if any, to which conditions or events raise substantial doubt about the Company’s ability to ~~continue~~

as a going concern, or the extent to which mitigating plans sufficiently alleviate any such substantial doubt, as well as whether or not liquidation is imminent, requires significant judgement by management.

The Company has evaluated whether there are conditions and events, considered in the aggregate, that raise substantial doubt about the Company’s ability to continue as a going concern within one year after the date the consolidated financial statements contained in this report are issued.

Based on our cash, cash equivalents and short-term investments at September 30, 2020, our recent net losses, and our obligations that are due within the next 12 months, including $69.0 million aggregate principal amount of our 1.75% Convertible Senior Notes due 2021 that mature on June 15, 2021, management has concluded that there is substantial doubt regarding our ability to meet ~~our obligations within one year after the date the consolidated financial statements in this report are issued and, therefore, to continue as a going concern.~~

~~Our ability to meet our~~its future operating requirements, repay ~~our~~its liabilities, and meet ~~our~~its other obligations ~~and continue as a going concern~~ are dependent upon a number of factors, including ~~our~~its ability to generate cash from product sales, reduce planned expenditures, and obtain additional financing. If ~~we are~~the Company is unable to generate sufficient cash flow from the sale of ~~our~~its products, ~~we may~~it will be required to adopt one or more alternatives, subject to the restrictions contained in the indenture governing ~~our 6.00% Convertible Senior Secured Notes~~its convertible senior secured notes due 2024, such as further reducing expenses, selling assets, restructuring debt, or obtaining additional equity capital on terms that may be onerous and which are likely to be highly dilutive. Also, ~~our~~the Company’s ability to raise additional capital and repay or restructure ~~our~~its indebtedness will depend on the capital markets and ~~our~~its financial condition at such time, among other factors. In addition, financing may not be available when needed, at all, on terms acceptable to us or in accordance with the restrictions described above. As a result of these factors, the Company may not be able to engage in any of the alternative activities, or engage in such activities on desirable terms, which could harm the Company’s business, financial condition and results of operations, as well as result in a default on the Company’s debt obligations. If the Company is unable to take these actions, it may be forced to significantly alter its business strategy, substantially curtail its current operations, or cease operations altogether.

~~Due~~At September 30, 2021, the Company had $36.2 million of cash and cash equivalents, compared to ~~these uncertainties,~~$71.4 million at December 31, 2020. The Company’s September 30, 2021 cash and cash equivalents balance does not include restricted cash, currently held in escrow under the terms of its convertible senior secured notes due 2024, which may potentially be released from escrow if the Company pays interest on those notes using shares of its common stock. The Company incurred a net loss of $83.4 million for the nine-month period ended September 30, 2021.

Based on the Company’s cash and cash equivalents at September 30, 2021, and the Company’s obligations that are due within the next twelve months, management has concluded that there is no substantial doubt ~~about~~regarding the Company’s ability to ~~continue as going concern. These unaudited condensed~~meet its obligations within one year after the date the consolidated financial statements and accompanying notes have been prepared on the basis that the Company will continue as a going concern, and do not include any adjustments to reflect the possible future effects on the recoverability and classification of assets or the amounts and classification of liabilities that may result from the possible inability of the Company to continue as a going concern.included in this report are issued.

Subsequent events are defined as those events or transactions that occur after the balance sheet date, but before the financial statements are filed with the Securities and Exchange Commission. The Company completed an evaluation of the impact of any subsequent events through the date these financial statements were issued, and determined there were no subsequent events that required disclosure or adjustment in these financial statements.

In June 2016, the FASB issued ASU 2016-13, “Financial Instruments – Credit Losses” (Topic 326): Measurement of Credit Losses on Financial Instruments and subsequently amended by ASU 2019-04 and ASU 2019-05 which introduces a forward-looking approach, based on expected losses, to estimate credit losses on certain types of financial instruments, including trade receivables. This new standard amends the current guidance on the impairment of financial instruments. The ASU adds to U.S. GAAP an impairment model known as current expected credit loss (CECL) model that is based on expected losses rather than incurred losses. Under the new guidance, an entity will recognize as an allowance its estimate of expected credit losses. The ASU is effective for fiscal years beginning after December 15, 2019, and interim periods within those fiscal years with early adoption permitted. The Company adopted this guidance effective January 1, 2020. The adoption of this guidance did not have a material impact on the consolidated financial statements.

~~In August 2018, the FASB issued ASU 2018-13 “Fair Value Measurement (Topic 820): “Disclosure Framework—Changes to the Discl~~osure Requirements for Fair Value Measurement.” The amendment in this ASU eliminate, add and modify certain disclosure requirements for fair value measurements as part of its disclosure framework project. Entities will no longer be required to disclose the amount of and reasons for transfers between Level 1 and Level 2 of the fair value hierarchy, but public business entities will be required to disclose the range and weighted average used to develop significant unobservable inputs for Level 3 fair value measurements. The ASU is effective for all entities for fiscal years beginning after December 15, 2019, and interim periods within those fiscal years with early adoption permitted. The Company adopted this guidance effective January 1, 2020. The adoption of this guidance did not have a significant impact on the consolidated financial statements.

In August 2018, the FASB issued ASU 2018-15, “Customer’s Accounting for Implementation Costs Incurred in a Cloud Computing Arrangement That Is a Service Contract.” The ASU clarifies certain aspects of ASU 2015-05, “Customer’s Accounting for Fees Paid in a Cloud Computing Arrangement,” which was issued in April 2015. Specifically, the ASU 2018-15 aligns the requirements for capitalizing implementation costs incurred in a hosting arrangement that is a service contract with the requirements for capitalizing implementation costs incurred to develop or obtain internal-use software (and hosting arrangements that include an internal-use software license).” The ASU is effective for fiscal years beginning after December 15, 2019, and interim periods within those fiscal years with early adoption permitted. The Company adopted this guidance effective January 1, 2020. The adoption of this guidance did not have an impact on the consolidated financial statements.

In November 2018, the FASB issued ASU 2018-18, Collaborative arrangements (Topic 808): Clarifying the Interaction between Topic 808 and Topic 606. ASU 2018-18 clarifies that certain transactions between participants in a collaborative arrangement should be accounted for under ASC 606 when the counterparty is a customer and precludes an entity from presenting consideration from a transaction in a collaborative arrangement as revenue from contracts with customers if the counterparty is not a customer for that transaction. The ASU is effective for fiscal years beginning after December 15, 2019, and interim periods within those fiscal years with early adoption permitted. ~~The Company adopted this guidance effective January 1, 2020. The adoption of this guidance did not have a significant impact on the consolidated financial statements.~~

In December 2019, the FASB issued ASU 2019-12, Simplifying the Accounting for Income Taxes. The ASU enhances and simplifies various aspects of the income tax accounting guidance in ASC 740 and removes certain exceptions for recognizing deferred taxes for investments, performing intraperiod allocation and calculating income taxes in interim periods. The ASU also adds guidance to reduce complexity in certain areas, including recognizing deferred taxes for tax goodwill and allocating taxes to members of a consolidated group. This ASU is effective for fiscal years beginning after December 15, 2020, and interim periods within those fiscal years with early adoption permitted. The Company ~~is currently evaluating the impact the~~adopted this guidance effective January 1, 2021. The adoption of this guidance ~~may~~did not have a significant impact on ~~its~~the consolidated financial statements.

In March 2020, the FASB issued ASU 2020-03, “Codification Improvements to Financial Instruments”: The amendments in this update are to clarify, correct errors in, or make minor improvements to a variety of ASC topics. The changes in ASU 2020-03 are not expected to have a significant effect on current accounting practices. The ASU improves various financial instrument topics in the Codification to increase stakeholder awareness of the amendments and to expedite the improvement process by making the Codification easier to understand and easier to apply by eliminating inconsistencies and providing clarifications. The ASU is effective for smaller reporting companies for fiscal years beginning after December 15, ~~2020~~2022 with early application permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements.

In August 2020, the FASB issued ASU 2020-06, Accounting for Convertible Instruments and Contracts in an Entity’s Own Equity. This update simplifies the accounting for convertible instruments by eliminating the cash conversion and beneficial conversion feature models which require separate accounting for embedded conversion features. This update also amends the guidance for the derivatives scope exception for contracts in an entity’s own equity to reduce form-over-substance-based accounting conclusions and requires the application of the if-converted method for calculating diluted earnings per share. ASU 2020-06 is effective for smaller reporting companies for fiscal periods beginning after December 15, 2023, including interim periods within those fiscal years. Early adoption is permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements.

In May 2021, the FASB issued ASU 2021-04, Earnings Per Share (Topic 260), Debt – Modifications and Extinguishments (Subtopic 470-50), Compensation – Stock Compensation (Topic 718), and Derivatives and Hedging – Contracts in Entity’s Own Equity (Subtopic 815-40): Issuer’s Accounting for Certain Modifications or Exchanges of Freestanding Equity-Classified Written Call Options. The FASB is issuing this update to clarify and reduce diversity in an issuer’s accounting for modifications or exchanges of freestanding equity-classified written call options (for example, warrants) that remain equity classified after modification or exchange. The amendments in this update are effective for all entities for fiscal years beginning after December 15, 2021, including interim periods within those fiscal years. Early adoption is permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements.

In accordance with ASC 606, the Company recognizes revenue when the customer obtains control of a promised good or service, in an amount that reflects the consideration to which the Company expects to be entitled in exchange for the good or service. ASC 606 requires entities to record a contract asset when a performance obligation has been satisfied or partially satisfied, but the amount of consideration has not yet been received because the receipt of the consideration is conditioned on something other than the passage of time. ASC 606 also requires an entity to present a revenue contract as a contract liability in instances when a customer pays consideration, or an entity has a right to an amount of consideration that is unconditional (e.g. receivable), before the entity transfers a good or service to the customer. We did not have any contract assets or any contract liabilities as of September 30, ~~2020~~2021 and ~~2019.~~2020.

The following table disaggregates our revenue by major ~~source:~~source. The Company’s Royalty Revenue set forth below relates to Fampyra royalties payable under the Company’s License and Collaboration Agreement with Biogen. See Note 9 for additional information on the Company’s related payment obligation to HealthCare Royalty Partners, or HCRP, in connection with a 2017 royalty purchase agreement with HCRP.

(In thousands)	Three-month period ended September 30, 2020		Three-month period ended September 30, 2019		Nine-month period ended September 30, 2020		Nine-month period ended September 30, 2019		Three-month period ended September 30, 2021		Three-month period ended September 30, 2020		Nine-month period ended September 30, 2021		Nine-month period ended September 30, 2020
Revenues:
Net product revenues:
Ampyra	$	27,343	$	39,322	$	73,546	$	123,579	$	20,026	$	27,343	$	62,035	$	73,546
Inbrija		5,833		4,889		14,901		9,164		7,804		5,833		19,240		14,901
Other		1,511		589		1,706		582		21		1,511		22		1,706
Total net product revenues		34,687		44,800		90,153		133,325		27,851		34,687		81,297		90,153
Milestone revenues		15,000		—		15,000		—		—		15,000		—		15,000
Royalty revenues		3,403		2,922		9,654		8,586		3,605		3,403		10,807		9,654
Total net revenues	$	53,090	$	47,722	$	114,807	$	141,911	$	31,456	$	53,090	$	92,104	$	114,807

During the three‑month periods ended September 30, ~~2020~~2021 and ~~2019,~~2020, the Company recognized share-based compensation expense of ~~$2.5~~$0.9 million and ~~$3.3~~$2.5 million, respectively. During the nine-month periods ended September 30, ~~2020~~2021 and ~~2019,~~2020, the Company recognized share-based compensation expense of ~~$6.5 million~~$2.5 and ~~$11.5~~$6.5 million, respectively. Activity in options and restricted stock during the nine-month period ended September 30, ~~2020~~2021 and related balances outstanding as of that date are reflected below. The weighted average fair value per share of options granted to employees for the three-month periods ended September 30, ~~2020~~2021 and ~~2019~~2020 were approximately ~~$0.39~~$2.56 and ~~$2.69,~~$2.31, respectively. The weighted average fair value per share of options granted to employees for the nine-month periods ended September 30, ~~2020~~2021 and ~~2019~~2020 were approximately ~~$0.66~~$2.58 and ~~$6.49,~~$3.96, respectively.

The following table summarizes share-based compensation expense included within the consolidated statements of operations:

A summary of share-based compensation activity for the nine-month period ended September 30, ~~2020~~2021 is presented below:

Number of
Shares
(In thousands)

Weighted
Average
Exercise
Price

Weighted
Average
Remaining
Contractual
Term

Intrinsic
Value
(In thousands)

Balance at January 1, 2020

10,469

$
22.96

Granted

237

1.00

Cancelled

(2,339
)

27.41

Exercised

—

—

Balance at September 30, 2020

8,366

$
21.09

6.0

$
—

Vested and expected to vest at
September 30, 2020

8,342

$
21.14

6.0

$
—

Vested and exercisable at
September 30, 2020

6,482

$
25.72

4.7

$
—

	Number of Shares (In thousands)			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term		Intrinsic Value (In thousands)
Balance at January 1, 2021		1,331		$	127.13
Granted		61			3.78
Cancelled		(309	)		109.27
Exercised		—			—
Balance at September 30, 2021		1,083		$	125.27		4.2	$	43
Vested and expected to vest at September 30, 2021		1,082		$	125.33		4.2	$	42
Vested and exercisable at September 30, 2021		1,001		$	133.65		3.9	$	13

Unrecognized compensation cost for unvested stock options, restricted stock awards, and ~~performance~~restricted stock units as of September 30, ~~2020~~2021 totaled ~~$7.8~~$2.6 million and is expected to be recognized over a weighted average period of approximately ~~1.4~~0.9 years.

During the three and nine‑month periods ended September 30, ~~2020,~~2021, the Company did ~~not~~0t make any repurchases of shares.

The following table sets forth the computation of basic and diluted loss per share for the three and nine-month periods ended September 30, ~~2020~~2021 and ~~2019:~~2020:

(In thousands, except per share data)	Three-month period ended September 30, 2020		Three-month period ended September 30, 2019			Nine-month period ended September 30, 2020			Nine-month period ended September 30, 2019			Three-month period ended September 30, 2021			Three-month period ended September 30, 2020		Nine-month period ended September 30, 2021			Nine-month period ended September 30, 2020
Basic and diluted
Net income (loss)—basic	$	7,347	$	(263,535	)	$	(16,546	)	$	(338,626	)	$	(27,071	)	$	7,347	$	(83,387	)	$	(16,546	)
Plus: Dilutive effect of convertible notes, net of tax		1,476		—			—			—						1,476		—			—
Net income (loss)—diluted	$	8,823	$	(263,535	)	$	(16,546	)	$	(338,626	)	$	(27,071	)	$	8,823	$	(83,387	)	$	(16,546	)

Weighted average common shares outstanding used in computing net income (loss) per share—basic		47,705		47,511			47,704			47,491
Plus: Dilutive effect of convertible notes		118,440		—			—			—
Weighted average common shares outstanding used in computing net income (loss) per share—diluted		166,145		47,511			47,704			47,491
Weighted average common shares outstanding used in computing net loss per share—basic													11,131			7,960		10,204			7,960
Plus: net effect of dilutive stock options and restricted common shares													—			19,740		—			—
Weighted average common shares outstanding used in computing net loss per share—diluted													11,131			27,700		10,204			7,960
Net income (loss) per share—basic	$	0.15	$	(5.55	)	$	(0.35	)	$	(7.13	)	$	(2.43	)	$	0.92	$	(8.17	)	$	(2.08	)
Net income (loss) per share—diluted	$	0.05	$	(5.55	)	$	(0.35	)	$	(7.13	)	$	(2.43	)	$	0.32	$	(8.17	)	$	(2.08	)

Securities that could potentially be dilutive are excluded from the computation of diluted loss per share when a loss from continuing operations exists or when the exercise price exceeds the average closing price of the Company’s common stock during the period, because their inclusion would result in an anti-dilutive effect on per share amounts.

The following amounts were not included in the calculation of net loss per diluted share because their effects were anti-dilutive:

Performance share units are excluded from the calculation of net loss per diluted share as the performance criteria has not been met for the three and nine-month periods ended September 30, ~~2020~~2021 and ~~2019.~~2020. The impact of the convertible senior notes was determined to be anti-dilutive and excluded from the calculation of net loss per diluted share for the three and nine-

month periods ended September 30, 2021. Additionally, for the three and ~~nine-month~~nine month periods ended September 30, 2020, the impact of our outstanding convertible notes was determined to be dilutive and anti-dilutive, respectively. ~~As a result, for the three-month period ended September 30, 2020 the Company adjusted the~~

numerator amount used in the calculation of net income per diluted share to add back the interest expense associated with convertible notes of $6.8 million, which is partially offset by the derivative liability gain of $4.9 million and $0.5 tax impact. Additionally, the 118,440 million common shares required to fully convert the outstanding convertible notes were included and excluded from the denominator in the calculation of net loss per diluted share under the if converted method for the three and nine-month periods ended September 30, 2020, respectively.

On March 27, 2020, the CARES Act was signed into law, which enacted several tax favorable, business-related provisions. The Company reviewed the enacted provisions to determine which provisions should be considered for the three-month period ended September 30, 2020. Under the new law, the CARES Act provides that NOLs arising in a taxable year beginning after December 31, 2017, and before January 1, 2021, can be carried back to each of the five taxable years preceding the taxable year of such loss. The Company has considered the impact to the tax provision for the carryback of net operating losses to prior periods of taxable income incurred within the period allowed under the CARES Act. The result of carrying back these losses allowed the Company to realize certain deferred tax assets and a corresponding release of the valuation allowance of approximately $1.8 million. In July 2020, the Company received an income tax refund of $12.7 million including interest from the Internal Revenue Service, related to the 2019 net operating loss carryback. The Company recorded a tax receivable of $1.4 million for the anticipated 2020 net operating loss carryback claim as of September 30, 2020.

The Company’s effective income tax rate differs from the U.S. statutory rate primarily due to an increase in the valuation allowance and expense recorded on the equity ~~forfeitures, offset by the benefit of net operating loss carryback under the CARES act recorded at 21% to recover taxes paid at the previous statutory rate of 35%~~forfeiture..

For the three-month periods ended September 30, ~~2020~~2021 and ~~2019,~~2020, the Company recorded a benefit of $3.1 million and a provision of $(1.5) ~~million~~ ~~and $(0.02)~~ million for income taxes, respectively. The effective income tax rates for the Company for the three-month periods ended September 30, 2021 and 2020 were 10.2% and ~~2019 were~~ 16.6% ~~and 0%~~, respectively. The variances in the effective tax rates for the three-month period ended September 30, ~~2020~~2021 as compared to the three-month period ended September 30, ~~2019~~2020 was due primarily to the valuation allowance recorded on deferred tax assets ~~for which no tax benefit can be recognized, goodwill impairment~~ for which no tax benefit can be recognized and the benefit recorded on the net operating loss carryback under the CARES ~~act~~Act recorded at 21% to recover taxes paid at the previous statutory rate of 35%.

For the nine-month periods ended September 30, ~~2020~~2021 and ~~2019,~~2020, the Company recorded a benefit of ~~$5.0~~$6.8 million and ~~$0.5~~a benefit of $5.0 million for income taxes, respectively. The effective income tax rates for the Company for the nine-month periods ended September 30, 2021 and 2020 were 7.53% and ~~2019 were~~ 23.1% ~~and 0.14%~~, respectively. The variance in effective tax rates for the nine-month period ended September 30, ~~2020~~2021 as compared to the nine-month period ended September 30, ~~2019~~2020 was due primarily to the valuation allowance recorded on deferred tax assets for which no tax benefit can be recognized, ~~goodwill impairment for which no tax benefit can be recognized,~~forfeitures of equity based awards and the benefit recorded on the net operating loss carryback under the CARES ~~act~~Act recorded at 21% to recover taxes paid at the previous statutory rate of 35%.

The Company continues to evaluate the realizability of its deferred tax assets on a quarterly basis and will adjust such amounts in light of changing facts and circumstances including, but not limited to, future projections of taxable income, tax legislation, rulings by relevant tax authorities, the progress of ongoing tax audits and the regulatory approval of products currently under development. Any changes to the valuation allowance or deferred tax assets and liabilities in the future would impact the Company's income taxes.

The ~~Company’s state examination~~Company was notified during the first quarter of 2021 that it is being audited by the state of Massachusetts for the tax ~~periods 2016~~years 2018 and ~~2017 was completed during~~2019. There have been no proposed adjustments at this stage of the ~~period ended September 30, 2020. The Company was assessed a tax of approximately $0.2 million.~~examination.

The Company also has an ongoing state ~~examinations~~examination in New Jersey ~~and Minnesota~~ which ~~cover a range of~~for the tax periods, 2015 – 2018. There have been no proposed adjustments at this stage of the ~~examinations.~~examination. The Minnesota examinations for 2016 and 2017 were closed during the quarter with no changes.

The following table presents information about the Company’s assets and liabilities measured at fair value on a recurring basis as of September 30 ~~30, 2020~~, 2021 and December 31, ~~2019~~2020 and indicates the fair value hierarchy of the valuation techniques utilized to determine such fair value. In general, fair values determined by Level 1 inputs utilize quoted prices

(unadjusted) in active markets for identical assets or liabilities. Fair values determined by Level 2 inputs utilize data points that are observable, such as quoted prices, interest rates, exchange rates and yield curves. Fair values determined by Level 3 inputs utilize unobservable data points for the asset or liability. The Company’s Level 1 assets consist of investments in a Treasury money market fund and U.S. government securities. The Company’s level 2 assets consist of investments in corporate bonds and commercial paper which are categorized as short-term investments for investments with original maturities between three months and one year. The Company’s Level 3 liabilities represent acquired contingent consideration related to the acquisition of Civitas which are valued using a probability weighted discounted cash flow valuation approach and derivative liabilities related to conversion options for the convertible senior notes due December 2024 which are valued using a binomial model. For assets and liabilities not accounted for at fair value, the carrying values of these accounts approximates their fair values at September 30, ~~2020,~~2021, except for ~~the fair value of the Company’s convertible senior notes due June 2021, which was approximately $55.3 million and~~ the fair value of the Company’s convertible senior notes due December 2024, which was approximately ~~$119.3~~$167.7 million as of September 30, ~~2020.~~2021. The Company estimates the fair value of its notes utilizing market quotations for the debt (Level 2).

(In thousands)	Level 1		Level 2		Level 3		Level 1		Level 2		Level 3
September 30, 2020
September 30, 2021
Assets Carried at Fair Value:
Money market funds	$	31,283	$	—	$	—	$	12,192	$	—	$	—
Corporate bonds		—		5,347		—		—		—		—
Liabilities Carried at Fair Value:
Acquired contingent consideration								—		—		43,000
Derivative liability - conversion option		—		—		832		—		—		325
Acquired contingent consideration		—		—		46,100
December 31, 2019
December 31, 2020
Assets Carried at Fair Value:
Money market funds	$	2,219	$	—	$	—	$	36,693	$	—	$	—
Commercial paper		—		26,569		—		—		—		—
Corporate bonds		—		37,185		—		—		—		—
Liabilities Carried at Fair Value:
Acquired contingent consideration								—		—		48,200
Derivative liability - conversion option		—		—		59,409		—		—		1,193
Acquired contingent consideration		—		—		80,300

The following table presents additional information about liabilities measured at fair value on a recurring basis and for which the Company utilizes Level 3 inputs to determine fair value.

The Company estimates the fair value of its acquired contingent consideration using a probability weighted discounted cash flow valuation approach based on estimated future sales expected from Inbrija (levodopa inhalation powder), an FDA approved drug for the treatment of OFF periods in Parkinson’s disease. Using this approach, expected probability adjusted future cash flows are calculated over the expected life of the agreement and discounted to estimate the current value of the liability at the period end date. Some of the more significant assumptions made in the valuation include (i) the estimated revenue forecast for Inbrija, (ii) probabilities of success, and (iii) discount periods and rate. The milestone payments ranged from $1.0 million to $22.0 million for Inbrija. The ~~estimated revenue forecast for Inbrija is based on peak annual sales of $300 to $500 million. The~~ discount rate used in the valuation was 20.5% for the three and nine-month periods ended September 30, ~~2020.~~2021. The valuation is performed quarterly and changes in the fair value of the contingent consideration are included in the statement of operations. For the three and nine-month periods ended September 30, ~~2020~~2021 and ~~2019,~~2020, changes in the fair value of the acquired contingent consideration were primarily due to updates to certain revenue and expense forecast assumptions. Additionally, for the nine-month periods ended September 30, 2020 and 2019, changes in the fair value of the acquired contingent consideration were partially offset by a reduction in the discount rate and a reduction in the forecast periods for the passage of time.

The acquired contingent consideration is classified as a Level 3 liability as its valuation requires substantial judgment and estimation of factors that are not currently observable in the market. If different assumptions were used for the various inputs to the valuation approach, including but not limited to, assumptions involving sales estimates for Inbrija and estimated discount rates, the estimated fair value could be significantly higher or lower than the fair value determined.

The following table represents a reconciliation of the derivative liability recorded in connection with the issuance of the convertible senior secured notes due ~~2024 acquired:~~2024:

During 2019, a derivative liability was initially recorded as a result of the issuance of the 6.00% Convertible Senior Secured Notes due 2024 (see Note 10). The fair value measurement of the derivative liability is classified as Level 3 under the fair value hierarchy as it has been valued using certain unobservable inputs. These inputs include: (1) share price as of the valuation date, (2) assumed timing of conversion of the Notes, (3) historical volatility of the share price, and (4) the risk-adjusted discount rate used to present value the probability-weighted cash flows. Significant increases or decreases in any of those inputs in isolation could result in a significantly lower or higher fair value measurement. The fair value of the derivative liability ~~as of September 30, 2020~~ was determined using a binomial model that calculates the fair value of the Notes with the conversion feature as compared to the fair value of the Notes without the conversion feature, with the difference representing the value of the conversion feature, or the derivative liability. There are several embedded features within the Notes which, upon issuance, did not meet the conditions for equity classification. As a result, these features were aggregated together and recorded as a derivative liability conversion option. The derivative liability conversion feature is measured at fair value on a quarterly basis and changes in the fair value will be recorded in the consolidated statement of operations. The Company received stockholder approval on August 28, 2020 to increase the number of authorized shares of the Company’s common stock from ~~80,000,000~~13,333,333 shares to ~~370,000,000~~61,666,666 shares. As a result of the share approval, the Company determined that multiple embedded conversion options met the conditions for equity classification. The Company performed a valuation of these conversion options as of September 17, 2020, which was the date the Company completed certain securities registration obligations. The valuation of these conversion options was based on key assumptions including the Company’s stock price of $0.58, the historical volatility rate of 113.0%, and risk-adjusted discount rate of 25.0%. The resulting fair value of these conversion options was calculated to be $18.3 million which was reclassified to equity and presented in the statement of stockholder’s equity as of September 30, 2020 net of the ~~$(4.4)~~$4.4 million tax impact. The ~~fair value~~equity component is not re-measured as long as it continues to meet the conditions for equity classification. The Company performed a valuation of the derivative liability related to certain embedded conversion features that are precluded from equity ~~classification for~~classification. The fair value of these conversion features was calculated to be $0.3 million as of September 30, 2021. Key inputs used in the calculation of the fair value include stock price, volatility, risky (bond) rate, and the last observed bond price during the nine-month period ended September 30, ~~2020 were determined based on key assumption including the Company’s~~2021.

~~stock price of $0.52, the historical volatility rate of 115.0%, and the risk-adjusted discount rate of 25.3%. The fair value of this conversion feature was calculated to be $0.8 million.~~

~~The Company has determined that all of its~~There were 0 available-for-sale investments are classified as available-for-sale. Available-for-sale debt securities are carried at fair value with interest on these investments included in interest income and are recorded based on quoted market prices. Available-for-sale investments consisted of the following at September 30, ~~2020~~2021 and December 31, ~~2019, respectively:~~

Short-term investments with maturities of three months or less from date of purchase have been classified as cash equivalents, and amounted to approximately ~~$31.3~~$12.2 million and ~~$2.2~~$36.7 million as of September 30, ~~2020~~2021 and December 31, ~~2019,~~2020, respectively. ~~Short-term~~There were 0 short-term investments ~~have~~will original maturities of greater than 3 months but less than 1 year ~~and amounted to approximately $5.3 million and $63.8 million~~ as of September 30, ~~2020~~2021 and December 31, ~~2019,~~2020, respectively. ~~The aggregate fair value of~~Additionally, there were no short-term investments in an unrealized loss position ~~amounted to approximately $0 and $25.5 million~~ as of September 30, ~~2020~~2021 and December 31, ~~2019,~~2020, respectively. ~~Short-term investments at September 30, 2020 primarily consisted of high-grade commercial paper and corporate bonds.~~ Long-term investments have original maturities of greater than 1 year. There were 0 investments classified as long-term at September 30, ~~2020~~2021 or December 31, ~~2019.~~2020. The Company has determined that there were no other-than-temporary declines in the fair values of its investments as of September 30, ~~2020~~2021 as the Company does not intend to sell its investments and it is not more likely than not that the Company will be required to sell its investments prior to the recovery of its amortized cost basis.

Unrealized holding gains and losses, which relate to debt instruments, are reported within accumulated other comprehensive income (AOCI) in the statements of comprehensive income. ~~The~~There were no changes in AOCI associated with ~~the~~ unrealized holding gains or losses on available-for-sale investments during the nine-month period ended September 30, ~~2020, were as follows (in thousands):~~

As of October 1, 2017, the Company completed a royalty purchase agreement with HealthCare Royalty Partners, or HCRP (“Royalty Agreement”). In exchange for the payment of $40 million to the Company, HCRP obtained the right to receive Fampyra royalties payable by Biogen under the License and Collaboration Agreement between the Company and

Biogen, up to an agreed upon threshold of royalties. When this threshold is met, if ever, the Fampyra ~~royalties~~royalty revenue will revert back to the Company and the Company will continue to receive the Fampyra ~~royalties~~royalty revenue from Biogen until the revenue stream ~~ends.~~ends (see Note 3). The transaction does not include potential future milestones to be paid.

The Company maintained the rights under the license and collaboration agreement with Biogen, therefore, the Royalty Agreement has been accounted for as a liability that will be amortized using the effective interest method over the life of the arrangement, in accordance with the relevant accounting guidance. The Company recorded the receipt of the $40 million payment from HCRP and established a corresponding liability in the amount of $40 million, net of transaction costs of approximately $2.2 million. The net liability is classified between the current and non-current portion of liability related to the sale of future royalties in the consolidated balance sheets based on the recognition of the interest and principal payments to be received by HCRP in the next 12 months from the financial statement reporting date. The total net royalties to be paid, less the net proceeds received will be recorded to interest expense using the effective interest method over the life of the Royalty Agreement. The Company will estimate the payments to be made to HCRP over the term of the Agreement based on forecasted royalties and will calculate the interest rate required to discount such payments back to the liability balance. Over the course of the Royalty Agreement, the actual interest rate will be affected by the amount and timing of net royalty revenue recognized and changes in forecasted revenue. On a quarterly basis, the Company will reassess the effective interest rate and adjust the rate prospectively as necessary.

The following table shows the activity within the liability account for September 30 ~~30, 2020~~, 2021 and December 31, ~~2019,~~2020, respectively:

On December 24, 2019, the Company completed the private exchange of $276.0 million aggregate principal amount of ~~its outstanding~~then-outstanding 1.75% Convertible Senior Notes due 2021 (the “2021 Notes”) for a combination of newly-issued 6.00% Convertible Senior Secured Notes due 2024 (the “2024 Notes”) and cash. For each $1,000 principal amount of exchanged 2021 Notes, the Company issued $750 principal amount of the 2024 Notes and made a cash payment of $200 (the “Exchange”). In the aggregate, the Company issued approximately $207.0 million aggregate principal amount of the 2024 Notes and paid approximate $55.2 million in cash to participating holders. The Exchange was conducted with a limited number of institutional holders of the 2021 Notes pursuant to Exchange Agreements dated as of December 20, 2019 (each, an “Exchange Agreement”).

The 2024 Notes were issued pursuant to an Indenture, dated as of December 23, 2019, among the Company, its wholly owned subsidiary, Civitas Therapeutics, Inc. (along with any domestic subsidiaries acquired or formed after the date of issuance, the “Guarantors”), and Wilmington Trust, National Association, as trustee and collateral agent (the ~~“Indenture”~~“2024 Indenture”). The 2024 Notes are senior obligations of the Company and the Guarantors, secured by a first priority security interest in substantially all of the assets of the Company and the Guarantors, subject to certain exceptions described in the Security Agreement, dated as of December 23, 2019, between the grantors party thereto and Wilmington Trust, National Association, as collateral agent (the “Security Agreement”).

The 2024 Notes will mature on December 1, 2024 unless earlier converted in accordance with their terms prior to such date. Interest on the 2024 Notes ~~will be~~is payable semi-annually in arrears at a rate of 6.00% per annum on each June 1 and December 1, beginning on June 1, 2020. The Company may elect to pay interest in cash or shares of the Company’s common stock, subject to the satisfaction of certain conditions. If the Company elects to pay interest in shares of common stock, such common stock will have a per share value equal to 95% of the daily volume-weighted average price for the 10 trading days ending on and including the trading day immediately preceding the relevant interest payment date. In June 2021, the Company issued 1,635,833 shares of common stock in satisfaction of the interest payable to holders of the 2024 Notes on June 1, 2021. In connection with this stock-based interest payment approximately $6.2 million of accrued interest was released from restricted cash and became available to the Company for other purposes.

The 2024 Notes ~~will be~~are convertible at the option of the holder into shares of common stock of the Company at any time prior to the close of business on the second scheduled trading day immediately preceding the maturity date. The ~~initial~~adjusted conversion rate for the 2024 Notes is ~~285.7142~~47.6190 shares of the Company’s common stock per $1,000 principal amount of 2024 Notes, representing an ~~initial~~adjusted conversion price of approximately ~~$3.50~~$21.00 per share of common stock. The conversion rate was adjusted to reflect the 1-for-6 reverse stock split effected on December 31, 2020 and is subject to ~~adjustment~~additional adjustments in certain circumstances as described in the 2024 Indenture.

The Company may elect to settle conversions of the 2024 Notes in cash, shares of the Company’s common stock or a combination of cash and shares of the Company’s common stock. Holders who convert their 2024 Notes prior to June 1, 2023 (other than in connection with a make-whole fundamental change) will also be entitled to an interest make-whole payment equal to the sum of all regularly scheduled stated interest payments, if any, due on such 2024 Notes on each interest payment date occurring after the conversion date for such conversion and on or before June 1, 2023. In addition, the Company will have the right to cause all 2024 Notes then outstanding to be converted automatically if the volume-weighted average price per share of the Company’s common stock equals or exceeds 130% of the adjusted conversion price for a specified period of time and certain other conditions are satisfied.

Holders of the 2024 Notes will have the right, at their option, to require the Company to purchase their 2024 Notes if a fundamental change (as defined in the 2024 Indenture) occurs, in each case, at a repurchase price equal to 100% of the principal amount of the 2024 Notes to be repurchased, plus accrued and unpaid interest, if any, to, but excluding, the applicable repurchase date. If a make-whole fundamental change occurs, as described in the 2024 Indenture, and a holder elects to convert its 2024 Notes in connection with such make-whole fundamental change, such holder may be entitled to an increase in the adjusted conversion rate as described in the 2024 Indenture.

items, indebtedness incurred to refinance the 2021 Notes, (iv) create liens on their assets, (v) sell their assets, (vi) enter into certain transactions with affiliates or (vii) merge, consolidate or sell of all or substantially all of their assets. The 2024 Indenture also requires the Company to make an offer to repurchase the 2024 Notes upon the occurrence of certain asset sales.

The 2024 Indenture provides that a number of events will constitute an event of default, including, among other things, (i) a failure to pay interest for 30 days, (ii) failure to pay the 2024 Notes when due at maturity, upon any required repurchase, upon declaration of acceleration or otherwise, (iii) failure to convert the 2024 Notes in accordance with the 2024 Indenture and the failure continues for five business days, (iv) not issuing certain notices required by the 2024 Indenture within a timely manner, (v) failure to comply with the other covenants or agreements in the 2024 Indenture for 60 days following the receipt of a notice of non-compliance, (vi) a default or other failure by the Company to make required payments under other indebtedness of the Company or certain subsidiaries having an outstanding principal amount of $30.0 million or more, (vii) failure by the Company or certain subsidiaries to pay final judgments aggregating in excess of $30.0 million, (viii) certain events of bankruptcy or insolvency and (ix) the commercial launch in the United States of a product determined by the U.S. FDA to be bioequivalent to Inbrija. In the case of an event of default arising from certain events of bankruptcy or insolvency with respect to the Company, all outstanding 2024 Notes will become due and payable immediately without further action or notice. If any other event of default occurs and is continuing, the trustee or the holders of at least 25% in aggregate principal amount of the then outstanding 2024 Notes may declare all the notes to be due and payable immediately.

The 2021 Notes received by the Company in the Exchange ~~have been~~were cancelled in accordance with their terms. Accordingly, upon completion of the Exchange, $69.0 million of the 2021 Notes remained outstanding.

The Company determined that the exchange of the 2021 Notes for 2024 Notes qualified for a debt extinguishment and recognized a gain on extinguishment of $55.1 million for the year ended December 31, 2019, representing the difference between the fair value of the liability component immediately before the exchange and the carrying value of the debt. The Company recorded an adjustment of $38.4 million to additional paid-in capital to adjust the equity component of 2021 Notes in connection with the extinguishment.

The Company assessed all terms and features of the 2024 Notes in order to identify any potential embedded features that would require bifurcation. As part of this analysis, the Company assessed the economic characteristics and risks of the 2024 Notes, including the conversion, put and call features. The Company concluded the conversion ~~feature~~features required bifurcation as a derivative. The fair value of the conversion feature derivative was determined based on the difference between the fair value of the 2024 Notes with the conversion ~~option~~options and the fair value of the 2024 Notes without the conversion ~~option~~options using a binomial model. The Company determined that the fair value of the derivative upon issuance of the 2024 Notes was $59.4 million and recorded this amount as a derivative liability with an offsetting amount as a debt discount

as a reduction to the carrying value of the 2024 Notes on the closing date, or December 24, 2019. There are several embedded features within the 2024 Notes which, upon issuance, did not meet the conditions for equity classification. As a result, these features were aggregated together and recorded as the derivative liability conversion option. The conversion feature is measured at fair value on a quarterly basis and the changes in the fair value of the conversion feature for the period will be recognized in the consolidated statements of operations. ~~The Company performed a valuation of the derivative liability for the period ended~~ ~~September~~ 30, 2020 and determined that the fair value of the derivative liability was $19.1 million representing a change of $4.9 million that is recognized in the consolidated statement of operations for the three-month period ended September 30, 2020.

The Company received stockholder approval on August 28, 2020 to increase the number of authorized shares of the Company’s common stock from ~~80,000,000~~13,333,333 shares to ~~370,000,000~~61,666,666 shares. As a result of the share approval, the Company determined that multiple embedded conversion options met the conditions for equity classification. The Company performed a valuation of these conversion options ~~for~~as of September 17, 2020, which was the ~~period ended September 30, 2020 and determined~~date the Company completed certain securities registration obligations. The resulting fair value of these conversion options was $18.3 million, which was reclassified to equity and presented in the statement of stockholder’s equity as of September 30, 2020, net of the ~~$(4.4)~~$4.4 million tax impact. The equity component is not re-measured as long as it continues to meet the conditions for equity classification. The Company performed a valuation of the derivative liability related to certain embedded conversion features that are precluded from equity classification. The fair value of these conversion features was calculated to be $~~0.8~~0.3 million as representing a decrease of $0.9 million that is recognized in the consolidated statement of operations for the nine-month period ended September 30, ~~2020.~~2021.

The outstanding ~~New~~2024 Note ~~balance~~balances as of September 30 ~~30, 2020~~, 2021 and December 31, ~~2019~~2020 consisted of the following:

The Company determined that the expected life of the 2024 Notes was equal to the period through December 1, 2024 as this represents the point at which the 2024 Notes will mature unless earlier converted in accordance with their terms prior to such date. Accordingly, the total debt discount of $75.1 million, inclusive of the fair value of the embedded ~~derivative~~ conversion feature derivative at issuance, is being amortized using the effective interest method through December 1, 2024. For the three and nine-month periods ended September 30 ~~30, 2020,~~, 2021, the Company recognized ~~$6.0~~$6.5 million and ~~$17.5~~$19.1 million, respectively, of interest expense related to the 2024 Notes at the effective interest rate of 18.1%. The fair value of the Company’s 2024 Notes was approximately ~~$119.3~~$167.7 million as of September 30 ~~30, 2020.~~, 2021.

In connection with the issuance of the 2024 Notes, the Company incurred approximately $5.7 million of debt issuance costs, which primarily consisted of underwriting, legal and other professional fees, and allocated these costs to the liability component and recorded as a reduction in the carrying amount of the debt liability on the balance sheet. The portion allocated to the 2024 Notes is amortized to interest expense over the expected life of the 2024 Notes using the effective interest method.

The following table sets forth total interest expense recognized related to the 2024 Notes for the three and nine-month periods ended September 30 ~~30,~~, 2021 and 2020:

On June 17, 2014, the Company issued $345 million aggregate principal amount of 1.75% Convertible Senior Notes due 2021 (the ~~2021 Notes) in an underwritten public offering. The net proceeds from the offering were $337.5 million after deducting the Underwriter’s discount and offering expenses paid by the Company.~~“2021 Notes”). On December 24, 2019, the Company completed the private exchange of $276.0 million aggregate principal amount of ~~its outstanding~~then-outstanding 2021 Notes for a combination of newly-issued 6.00% Convertible Senior Secured Notes due 2024 ~~(the “2024 Notes”)~~ and cash. The 2021 Notes received by the Company in the exchange ~~have been~~were cancelled in accordance with their terms. Accordingly, upon completion of the exchange, $69.0 million of the 2021 Notes remained outstanding.

~~The~~ On June 15, 2021, ~~Notes are convertible into cash, shares of~~ the ~~Company’s common stock or a combination of cash and shares of~~Company repaid the Company’s common stock, at the Company’s election, under certain circumstances as outlined in the indenture, based on an initial conversion rate, subject to adjustment, of 23.4968 shares per $1,000 principal amount of the 2021 Notes (representing an initial conversion price of approximately $42.56 per share).

~~The Company may redeem for cash all or part~~outstanding balance of the 2021 Notes at ~~the Company’s option, after June 20, 2017, under certain circumstances as outlined in the indenture.~~

~~The Company pays 1.75% interest per annum on the principal amount of the 2021 Notes, payable semiannually in arrears in~~their maturity date using cash on ~~June 15 and December 15 of each year. The 2021 Notes will mature on June 15, 2021.~~

If the Company undergoes a “fundamental change” (as defined in the Indenture), subject to certain conditions, holders may require the Company to repurchase for cash all or part of their 2021 Notes in principal amounts of $1,000 or an integral multiple thereof. The Indenture contains customary terms and covenants and events of default. If an event of default (other than certain events of bankruptcy, insolvency or reorganization involving the Company) occurs and is continuing, the Trustee by notice to the Company, or the holders of at least 25% in principal amount of the outstanding 2021 Notes by notice to the Company and the Trustee, may declare 100% of the principal of and accrued and unpaid interest, if any, on all the 2021 Notes to be due and payable. Upon such a declaration of acceleration, such principal and accrued and unpaid interest, if any, will be due and payable immediately. Upon the occurrence of certain events of bankruptcy, insolvency or reorganization involving the Company, 100% of the principal and accrued and unpaid interest, if any, on all of the 2021 Notes will become due and payable automatically. Notwithstanding the foregoing, the Indenture provides that, to the extent the Company elects and for up to 270 days, the sole remedy for an event of default relating to certain failures by the Company to comply with certain reporting covenants in the Indenture consists exclusively of the right to receive additional interest on the 2021 Notes.

The 2021 Notes will be senior unsecured obligations and will rank equally with all of the Company’s existing and future senior debt and senior to any of the Company’s subordinated debt. The 2021 Notes will be structurally subordinated to all existing or future indebtedness and other liabilities (including trade payables) of the Company’s subsidiaries and will be effectively subordinated to the Company’s existing or future secured indebtedness to the extent of the value of the collateral. The Indenture does not limit the amount of debt that the Company or its subsidiaries may incur.hand.

In accounting for the issuance of the 2021 Notes, the Company separated the 2021 Notes into liability and equity components. The carrying amount of the liability component was calculated by measuring the fair value of a similar liability that does not have an associated convertible feature. The carrying amount of the equity component representing the conversion option was determined by deducting the fair value of the liability component from the par value of the 2021 Notes as a whole. The equity component is not re-measured as long as it continues to meet the conditions for equity classification.

The outstanding ~~note balance~~2021 Note balances as of September 30 ~~30, 2020~~, 2021 and December 31, ~~2019~~2020 consisted of the following:

In connection with the issuance of the 2021 Notes, the Company incurred approximately $7.5 million of debt issuance costs, which primarily consisted of underwriting, legal and other professional fees, and allocated these costs to the liability

and equity components based on the allocation of the proceeds. Of the total $7.5 million of debt issuance costs, $1.3 million were allocated to the equity component and recorded as a reduction to additional paid-in capital and $6.2 million were allocated to the liability component and recorded as a reduction in the carrying amount of the debt liability on the balance sheet. The portion allocated to the liability component is amortized to interest expense over the expected life of the 2021 Notes using the effective interest method. The Company wrote off $1.2 million of issuance cost associated with the exchange of the 2021 Notes.

~~As of~~ ~~September~~ ~~30, 2020,~~On June 15, 2021, the ~~remaining contractual life~~Company repaid the outstanding balance of the 2021 Notes ~~is approximately 9 months.~~ at their maturity date using cash on hand. The effective interest rate on the liability component was approximately 4.8% for the period from the date of issuance through ~~September~~June 15 ~~30, 2020. The fair value of the Company’s 2021 Notes was approximately $55.3 million as of~~, 2021. ~~September~~ ~~30, 2020.~~

The following table sets forth total interest expense recognized related to the 2021 Notes for the three and nine-month periods ended September 30 ~~30, 2020~~, 2021 and ~~2019:~~2020:

In February 2016, the FASB issued ASU 2016-02, “Leases” Topic 842, which amends the guidance in former ASC Topic 840, Leases.

The interest rate implicit in lease contracts is typically not readily determinable. As such, the Company utilizes its incremental borrowing rate, which is the rate incurred to borrow on a collateralized basis over a similar term an amount equal to the lease payments in a similar economic environment.

Operating lease ROU assets and operating lease liabilities are recognized based on the present value of the future minimum lease payments over the lease term at the commencement date. The operating lease ROU asset also includes any lease payments made and excludes lease incentives and initial direct costs incurred, if any. Our leases have remaining lease terms of ~~2 years~~0.75 year to ~~7 years, some of which include options to extend~~5.25 years. The Company has exercised the ~~lease term for up to 15 years, and some of which include options~~option to terminate the Ardsley lease ~~within 2 years.~~with a termination date of June 22, 2022.

We lease certain office ~~space, manufacturing~~ and ~~warehouse~~lab space under arrangements classified as leases under ASC 842. Leases with an initial term of 12 months or less are not recorded on the balance sheet; we recognize lease expense for these leases on a straight-line basis over the lease term. Most leases include one or more options to renew, with renewal options ranging from 5 to 15 years. The exercise of lease renewal options is at our sole discretion. One of our leases also includes an option to early terminate the lease within 2 ~~years~~.

In June 2011, the Company entered into a 15-year lease for an aggregate of approximately 138,000 square feet of office and laboratory space in Ardsley, New York. In 2014, the Company exercised its option to expand into an additional 25,405 square feet of office space, which the Company occupied in January 2015. ~~The~~ On September 17, 2021, the Company ~~has options to extend~~sent the ~~term~~landlord of the Ardsley lease ~~for 3 additional~~ notice of exercise of the Company’s early termination option (the “~~five-year~~Early Termination Option”) under the lease. Pursuant to the Early Termination Option, the lease will terminate on June 22, 2022 (the “Early Termination Date”), subject to the conditions that (a) on the last business day before the Early Termination Date, the Company pays an early termination fee of approximately $4.7 million, (b) on the day immediately prior to the Early Termination Date, the Company is not in “Default” under the Lease beyond applicable cure periods, and (c) as of the Early Termination Date, the Company has ~~an option to terminate the lease after 10 years subject to payment of an early termination fee.~~ complied with its end-of-term obligations. The Company’s extension and early termination rights are subject to specified terms and conditions, including specified time periods when they must be exercised, and are also subject to limitations including that the Company not be in default under the lease.

The Ardsley lease provides for monthly payments of rent during the lease term. These payments consist of base rent, which takes into account the costs of the facility improvements funded by the facility owner prior to the Company’s occupancy, and additional rent covering customary items such as charges for utilities, taxes, operating expenses, and other facility fees and charges. The base rent is currently $5.0 million per year, which reflects an annual 2.5% escalation factor.

~~Through our~~Our Civitas subsidiary ~~we lease~~leased a manufacturing facility in Chelsea, Massachusetts which we ~~use~~used to manufacture ~~Inbrija. The approximately 90,000 square foot facility also includes office and laboratory space.~~ Inbrija through February 10, 2021.Civitas ~~leases~~leased this facility from North River Everett Ave, LLC pursuant to a lease with a term that expires on December 31, 2025, and Civitas ~~has~~had 2 additional extension options of five years each. On February 10, 2021, the Company completed the sale of its Chelsea manufacturing operations to Catalent Pharma Solutions. In connection with the sale, Civitas assigned the lease of the Chelsea facility to a Catalent affiliate (see Note 12).

~~In 2017, the Company’s Civitas subsidiary amended its existing Chelsea, Massachusetts lease.~~ ~~The amendment added expansion property located in Chelsea,~~ ~~Massachusetts next to the existing facility. The additional property~~ ~~includes land being used for parking and a free-standing warehouse building on the same site.~~

In 2018, the Company initiated a renovation and expansion of a building within the Chelsea manufacturing facility that increased the size of the facility to approximately 95,000 square feet. The project ~~has~~ added a new manufacturing production line for Inbrija and other ARCUS products that has greater capacity than the existing manufacturing line, and ~~has~~ created additional warehousing space for manufactured product.Although the project was substantially completed in late 2019, it will take additional time after completion of construction to obtain the approvals needed for use of the new production line for commercial manufacture, such as approvals from the FDA, Massachusetts state environmental permits, and approvals from other regulatory authorities. All costs to renovate and expand the facility ~~are~~through the date of assignment were borne by the ~~Company, and therefore will be accounted~~Company. Catalent is now responsible for ~~as leasehold improvements when~~finalizing the ~~renovation and~~ expansion, ~~is approved to be used for production.~~including obtaining needed regulatory approvals.

In October 2016, we entered into a 10-year lease agreement with a term commencing January 1, 2017, for approximately 26,000 square feet of lab and office space in Waltham, MA. The lease provides for monthly rental payments over the lease term. The base rent under the lease is currently $1.1 million per year.

Our leases have remaining lease terms of ~~2 years~~0.75 year to 75.25 years, which ~~assumes~~reflects the exercise of the early termination of our Ardsley, NY ~~lease. We do not include any renewal options in our~~ lease ~~terms when calculating our lease liabilities~~ as ~~we are not reasonably certain that we will exercise these options. When calculating~~described above. The calculation of the lease liability ~~we assume~~reflects the exercise of the Ardsley early termination ~~option.~~option as described above. The weighted-average remaining lease term for our operating leases was ~~3.9~~2.6 years at September 30, ~~2020.~~2021. The weighted-average discount rate was ~~7.14%~~7.13% at September 30, ~~2020.~~2021.

ROU assets and lease liabilities related to our operating leases are as follows:

We have lease agreements that contain both lease and non-lease components. We account for lease components together with non-lease components (e.g., common-area maintenance). The components of lease costs were as follows:

Future minimum commitments under all non-cancelable operating leases are as follows:

Supplemental cash flow information related to our operating leases are as follows:

On January 12, 2021 the Company and Catalent entered into an asset purchase agreement, pursuant to which the Company agreed to sell to Catalent certain assets related to the Company’s manufacturing operations located at the facilities situated in Chelsea, Massachusetts (the “Chelsea Facility”) and Waltham, Massachusetts (the “Waltham Facility”), for a purchase price of $80 million, plus an additional $2.3 million for raw materials transferred, and the assumption by Catalent of certain liabilities relating to such manufacturing activities. The Company determined that the criterion to classify the property and equipment and prepaid expenses related to the Chelsea manufacturing operations as assets held for sale within the Company’s consolidated balance effective December 31, 2020 were met. Accordingly, the assets were classified as current assets held for sale at December 31, 2020 as the Company, at that time, expected to divest the Chelsea manufacturing operations within the next twelve months.

The classification to assets held for sale impacted the net book value of the assets expected to be transferred upon sale. The estimated fair value of the Chelsea manufacturing operations was determined using the purchase price in the purchase agreement along with estimated broker, accounting, legal, and other selling expenses, which resulted in a fair value less costs to sell of approximately $71.8 million. The carrying value of the assets classified as held for sale was approximately $129.7 million, which included property and equipment of $129.6 million and prepaid expenses of $0.1 million. The Company recorded a loss on assets held for sale of $57.9 million against the Chelsea manufacturing operations as of December 31, 2020. Additionally, the expected divestiture of the Chelsea Facility group was not deemed to represent a fundamental strategic shift that would have a major effect on the Company’s operations, and accordingly, the operating results of the Chelsea manufacturing operations were not reported as discontinued operations in the Company’s consolidated statement of income as of December 31, 2020.

The Company closed the transaction on February 10, 2021. In addition to the property and equipment, prepaid expenses, and raw materials, the Company also assigned the lease of the Chelsea Facility to a Catalent affiliate, which had a net carrying value of $(0.5) million as of the close date. During the three-month period ended March 31, 2021, the Company recorded a gain on disposal of approximately $0.5 million based on the net assets transferred and final net proceeds received at the close.

During the nine-month period ended September 30, 2021, the Company incurred $4.6 million of restructuring charges, substantially all of which were cash expenditures for severance and other employee separation-related costs. Of the restructuring charges, $0.6 million were recorded in research and development expenses and $4.0 million were recorded in selling, general and administrative expenses for the nine-month period ended September 30, 2021.

A summary of the restructuring charges for the nine-month period ended September 30, 2021 is as follows:

~~The Company has~~On November 9, 2020, Drug Royalty III, L.P., and LSRC III S.ar.l. (collectively, “DRI”) filed an arbitration claim against us with the American Arbitration Association under a September 26, 2003 License Agreement that we originally entered into with Rush-Presbyterian St. Luke’s Medical Center (“Rush”). DRI previously purchased license royalty rights under the license agreement from Rush. DRI alleges a dispute ~~with another party which has asserted a claim related to~~ ~~royalties on~~over the last-to-expire patent covering sales of the drug Ampyra ~~(which lost exclusivity in July 2018).~~under the license agreement, and is claiming damages based on unpaid license royalties of $6 million plus interest. We believe we have valid defenses against this claim and intend to defend ourselves vigorously. While the Company is unable to determine the ultimate outcome of the dispute, and believes it has valid defenses and intends to defend itself vigorously, the Company determined that it is probable that the Company may incur a liability related to the dispute which the Company estimated could be $2 million, inclusive of its legal costs. The Company recorded a liability of $2 million infor the ~~three-month period~~year ended ~~September 30,~~December 31, 2020 related to the dispute, however, the Company notes that depending upon the ultimate outcome of the dispute, the potential liability could be more or less than the amount recorded. As of September 30, 2021, the Company continues to believe that the recorded liability established as of December 31, 2020 is appropriate.

In addition to the ~~dispute~~arbitration described above, from time to time the Company is involved in litigation or other legal proceedings relating to claims arising out of operations in the normal course of business. The Company has assessed all litigation and legal proceedings and does not believe that it is probable that a liability has been incurred or that the amount of any potential liability or range of losses can be reasonably estimated. As a result, the Company did not record any loss contingencies for these other matters. Litigation expenses are expensed as incurred.

On February 10, 2021, we sold our Chelsea manufacturing operations to Catalent Pharma Solutions. In connection with the sale, we entered into a long-term, global manufacturing services (supply) agreement with a Catalent affiliate pursuant to which they have agreed to manufacture Inbrija for us at the Chelsea facility. The manufacturing services agreement provides that Catalent will manufacture Inbrija (levodopa inhalation powder), to our specifications, and we will purchase Inbrija exclusively from Catalent during the term of the manufacturing services agreement; provided that such exclusivity requirement will not apply to Inbrija intended for sale in China. Under our agreement with Catalent, we are obligated to make minimum purchase commitments for Inbrija through the expiration of the agreement on December 31, 2030. During the three and nine-month periods ended September 30, 2021, the Company incurred approximately $4.0 million and $10.2 million, respectively, of minimum purchase commitments with Catalent, which are recognized as cost of sales within the Company’s consolidated statement of operations for the period. As of September 30, 2021, the minimum remaining purchase commitment to Catalent was $4.0 million through December 31, 2021, and $18.0 million annually each year thereafter.

Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations

The following discussion and analysis of our consolidated financial condition and results of operations should be read in conjunction with our unaudited consolidated financial statements and related notes included in this Quarterly Report on Form 10-Q.

We are a biopharmaceutical company focused on developing therapies that restore function and improve the lives of people with neurological disorders. We market Inbrija (levodopa inhalation powder), which is approved in the U.S. for intermittent treatment of OFF episodes, also known as OFF periods, in people with Parkinson’s disease treated with carbidopa/levodopa. Inbrija is for as needed use and utilizes our ARCUS pulmonary delivery system, a technology platform designed to deliver medication through inhalation that we believe has potential to be used in the development of a variety of inhaled medicines. We also market branded Ampyra (dalfampridine) Extended Release Tablets, 10 mg.

Our New Drug Application, or NDA, for Inbrija was approved by the U.S. Food and Drug Administration, or FDA, on December 21, 2018. The approval is for a single dose of 84 mg (administered as two capsules), which may be taken up to five times per day. Inbrija became commercially available in the U.S. on February 28, 2019. Currently, Inbrija is available in the U.S. without the need for a medical exception for approximately 96% of commercial health insurance ~~plan~~plans and approximately ~~25%~~27% of Medicare plan lives. Approximately one million people in the U.S. and 1.2 million Europeans are diagnosed with Parkinson’s; it is estimated that approximately 40% of people with Parkinson’s in the U.S. experience OFF periods. ~~We project~~Net revenue for Inbrija was $7.8 million for the quarter ended September 30, 2021 and $5.8 million for the quarter ended September 30, 2020. Due to uncertainties caused by past and potential future impacts of the COVID-19 pandemic and other factors, we are no longer able to provide projected peak U.S. annual net revenue of Inbrija. Actual peak U.S. Inbrija net revenue will likely be lower and could be materially lower than our prior projected peak sales range if, for example, disruptions to ~~be in~~ the ~~range of $300 to $500 million.~~healthcare system caused by the COVID-19 pandemic or other prescribing challenges continue into 2022 and beyond.

In September 2019, we announced that the European Commission, or EC, approved our Marketing Authorization Application, or MAA, for Inbrija. The approved dose is 66 mg (administered as two capsules) up to five times per day (per European Union, or EU, convention, this reflects emitted dose and is equivalent to the 84 mg labelled dose in the U.S.). Under the MAA, Inbrija is indicated in the EU for the intermittent treatment of episodic motor fluctuations (OFF episodes) in adult patients with Parkinson’s disease treated with a levodopa/dopa-decarboxylase inhibitor. Following the ratification of the Withdrawal Agreement between the United Kingdom and the EU, the UK left the EU on January 31, 2020. Effective January 1, 2021, Acorda was granted a grandfathered Marketing Authorization (MA) by the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK subject to completion of an administrative process that was approved by the MHRA in November 2021.

In July and November 2021, we announced that we entered into distribution and supply agreements with Esteve Pharmaceuticals to commercialize Inbrija in Spain and Germany, respectively. Under the terms of the Germany distribution agreement, we will receive a €5 million upfront payment, and we will receive additional sales-based milestones. Under the terms of both the Spain and Germany supply agreements, we will receive a significant double-digit percent of the selling price of Inbrija in exchange for supply of the product. Esteve will have the exclusive distribution rights to Inbrija in Spain and Germany and we will supply the product to Esteve for sale. Esteve expects to launch Inbrija in Spain in the fourth quarter of 2022, and in Germany by mid-2022. We are in discussions with potential partners ~~regarding the distribution~~for commercialization of Inbrija in other jurisdictions outside of the U.S., ~~with potential partners~~including in Europe and ~~Japan.~~other countries.

Ampyra became subject to competition from generic versions of Ampyra starting in ~~litigation with certain generic drug manufacturers relating to our five initial Orange Book-listed Ampyra patents. In 2017, the United States District Court for the District~~late 2018 as a result of ~~Delaware issued a~~an adverse U.S. federal district court ruling that ~~upheld our~~invalidated certain Ampyra Orange Book-listed patent that expired on July 30, 2018, but invalidated our four other Orange Book-listed patents pertaining to Ampyra that were set to expire between 2025 and 2027. Under this decision, which was upheld on appeal in September 2018, our patent exclusivity with respect to Ampyra terminated on July 30, 2018. patents. We have experienced a significant decline in Ampyra sales due to competition from several generic versions of ~~Ampyra that have been marketed since we lost our appeal of the District Court decision.~~Ampyra. Additional manufacturers may market generic versions of Ampyra, and we expect our Ampyra sales will continue to decline over time.

~~In 2019, we announced a corporate restructuring to reduce costs~~Net revenue for Ampyra was $20.0 million for the quarter ended September 30, 2021 and ~~focus our resources on~~$27.3 million for the ~~commercial launch of Inbrija, which is our key strategic priority for~~quarter ended September 30, 2020. We are continuing our efforts to manage our cost structure, such as by identifying potential operating efficiencies and opportunities to convert fixed costs into variable costs. One of our key initiatives is to monetize the excess capacity of our Chelsea manufacturing facility, which we believe could offset expenses and reduce our cost of goods for Inbrija.

In December 2019, we announced the successful completion of a private exchange of $276 million of our convertible senior notes due in 2021 in exchange for a combination of approximately $207 million aggregate principal amount of newly-issued convertible senior secured notes due 2024 and $55.2 million in cash. The convertible senior secured notes due 2024 have aan adjusted conversion price of approximately ~~$3.50~~$21.00 per share. As a result of the exchange, approximately $69 million of convertible senior notes due in 2021 ~~with a conversion price of $42.56, remain~~remained outstanding. ~~Addressing~~On June 15, 2021, we repaid the ~~remaining portion~~outstanding balance of the 2021 convertible senior notes ~~due 2021 is a top priority in addition to our focus~~at their maturity date using cash on ~~the Inbrija launch.~~hand. More information about the terms and conditions of the ~~2021 and~~ 2024 convertible notes is set forth in Note 10 to our Consolidated Financial Statements in included in this report as well as in Financing Arrangements ~~below.~~in the Management’s Discussion and Analysis of Financial Condition and Results of Operations section of this report.

In February 2021, we completed the sale of our Chelsea, Massachusetts manufacturing operations to Catalent Pharma Solutions. Pursuant to the transaction, Catalent paid us $80 million in cash, resulting in net proceeds to us of approximately $74 million after transaction fees and expenses and settlement of customary post-closing adjustments. In connection with the sale of the manufacturing operations, we entered into a long-term, global manufacturing services agreement with a Catalent affiliate for the supply of Inbrija. As part of the transaction, Catalent hired substantially all of our prior employees at the Chelsea facility as well as certain of our other employees at our Waltham, Massachusetts facility. We expect to save approximately $10 million in annual operating expenses related to the operation of the manufacturing facility.

In January 2021 and September 2021, we announced corporate restructurings to reduce costs, more closely align operating expenses with expected revenue, and focus our resources on Inbrija. As part of the January 2021 restructuring, we reduced headcount by approximately 16% through a reduction in force (excluding the employees that transferred to Catalent at the closing of the sale of our Chelsea manufacturing operations). As a result, we expect to realize estimated annualized cost savings related to the January 2021 headcount reduction of approximately $6 million beginning in the second quarter of 2021. As part of the September 2021 restructuring, we reduced headcount by approximately 15% through a reduction in force. Most of this reduction in force took place in September 2021, and it will be completed in the first quarter of 2022. The company expects to realize estimated annualized cost savings of approximately $20 million from the September corporate restructuring beginning in 2022. The Company estimates that it will incur approximately $5.5 million of pre-tax charges, substantially all of which are cash expenditures, for severance and other employee separation-related costs in connection with the restructurings, approximately $4.6 million of which were incurred during the nine-month period ended September 30, 2021.

In January 2021, we entered into an At The Market (ATM) Offering Agreement with H.C. Wainwright & Co., LLC as sales agent. Pursuant to the ATM agreement, we may offer and sell shares of our common stock having an aggregate value of up to $15.25 million in an at-the-market offering, subject to a 3% sales commission payable to H.C. Wainwright. If we elect to use the ATM agreement, H.C. Wainwright would be obligated to use commercially reasonable efforts consistent with its normal trading and sales practices and applicable law and regulations to sell shares in accordance with our instructions (including as to price, time or size limit or other parameters or conditions that we may impose). We have not yet sold any shares under the ATM agreement.

On ~~July 13, 2020,~~September 17, 2021, we ~~received a U.S. income tax refund from~~sent to BMR-Ardsley Park LLC (“BMR”) notice of exercise of our early termination option (the “Early Termination Option”) under our Lease dated as of June 23, 2011, between us and BMR (as amended, the ~~Internal Revenue Service~~“Lease”). The Lease is for the Company’s Ardsley, N.Y. corporate headquarters, which we believe is substantially larger than our needs for the foreseeable future. Pursuant to the Early Termination Option, the Lease will terminate on June 22, 2022 (the “Early Termination Date”), subject to the conditions that (a) on the last business day before the Early Termination Date, we pay an early termination fee of approximately ~~$12.4~~$4.7 million, ~~plus interest of $0.3 million, pursuant~~(b) on the day immediately prior to the ~~Coronavirus Aid, Relief,~~Early Termination Date, we are not in “Default” under the Lease beyond applicable cure periods, and Economic Security Act (“CARES Act”). Under the CARES Act, among other things, net operating losses arising in a taxable year beginning after December 31, 2017, and before January 1, 2021, can be carried back to the preceding five years to apply against taxable income reported in such

~~years. Pursuant to this provision~~(c) as of the ~~CARES Act, the Company was eligible to carry back 2019 net operating losses to tax years 2017 and 2018, resulting in the refund.~~Early Termination Date, we have complied with our end-of-term obligations.

As of September 30, ~~2020,~~2021, we had cash, cash equivalents ~~short-term investments~~ and restricted cash of approximately ~~$101.3~~$61.9 million. Restricted cash includes ~~$37.3~~$24.8 million in escrow related to the 6% semi-annual interest portion of the convertible senior secured notes due ~~2024.~~2024, which is payable in cash or stock. As further described ~~below under~~ in Note 10 to our Consolidated Financial

Statements included in this report as well as in Financing Arrangements, in the Management’s Discussion and Analysis of Financial Condition and Results of Operations section of this report, if we are permitted under the notes indenture and we elect to pay interest due in stock, ~~the~~a corresponding amount of restricted cash equivalent will be released from escrow. We intend to pay the interest due on December 1, 2021 in stock.

On ~~October 30,~~December 31, 2020, we ~~received~~filed an amendment to our Certificate of Incorporation which effected, as of 4:01 p.m. Eastern Time on December 31, 2020, a ~~$15 million milestone payment~~1-for-6 reverse stock split of the shares of our outstanding common stock and proportionate reduction in the number of authorized shares of our common stock from ~~Biogen International GmbH~~370,000,000 to 61,666,666. Our common stock began trading on a split-adjusted basis on The Nasdaq Global Select Market commencing upon market open on January 4, 2021. The common stock continued to trade under the symbol “ACOR” after the reverse stock split became effective. The reverse stock split applied equally to all outstanding shares of the common stock and did not modify the rights or preferences of the common stock. The reverse stock split also resulted in a corresponding adjustment to outstanding equity awards as well as shares reserved for future issuance under our ~~license~~incentive compensation plans. All figures in this report relating to shares of our common stock (such as share amounts, per share amounts, and ~~collaboration with Biogen. Biogen markets Ampyra outside~~conversion rates and prices), including in the ~~U.S. as Fampyra. We became entitled~~financial statements and accompanying notes to the ~~milestone payment based on Biogen’s ex-U.S. net sales of Fampyra exceeding $100 million over~~financial statements, have been retroactively restated to reflect the four consecutive quarters ending with the third quarter of 2020. This payment was recorded as milestone revenue in the third quarter, but is not included in our third quarter-end cash balance because it was received in October 2020. We will retain approximately $14 million of the milestone payment net1-for-6 reverse stock split of our ~~payment obligations to another party.~~common stock.

Our business and financial condition have been impacted by, and are subject to risks resulting from, the COVID-19 (novel coronavirus) pandemic. The COVID-19 pandemic has ~~already~~ caused significant disruptions in the healthcare industry. The duration of the pandemic is difficult to predict, and it is likely to have ongoing impacts as it continues. The travel restrictions, “shelter in place” orders, quarantine policies, vaccine mandates and general concerns about the spread of COVID-19 have disrupted the delivery of healthcare to patients, for example making it more difficult for some patients to visit with their physician and obtain pharmaceutical prescriptions. Also, healthcare office staffing shortages may delay the administrative work, and particularly insurance-related documentation, needed to obtain reimbursement for prescriptions. We believe these factors contributed to ~~decreases~~volatility in new Inbrija prescriptions during ~~2020. For example, we experienced a decrease~~2020 and are continuing to impact prescriptions in new Inbrija prescriptions late in the first quarter and during part of the second quarter, followed by a period of new prescription growth through July, and then another period of decrease in August and September. We have seen a resumed upward trajectory in new prescriptions since late September, but the ongoing impact of the COVID-19 pandemic on prescriptions is uncertain.2021.

The COVID-related policies, restrictions, mandates, and concerns may disrupt our operations and those of our customers and suppliers. Also, our operations could be interrupted if we or our customers or suppliers lose the services of key employees or consultants who become ill from COVID-19. These types of disruptions could potentially affect any of our critical business functions, and thus harm our business, including for example our manufacturing, sales and marketing operations as well compliance and certain general and administrative functions. The ultimate impact of the COVID-19 pandemic, or any other health epidemic, is highly uncertain and subject to change. We do not yet know the full extent of potential delays or impacts on our business, healthcare systems or the global economy as a whole. As the pandemic continues, it may result in a sustained ~~economic downturn that could affect~~impacts on demand for our products and our ability to access capital on reasonable terms, or at all.

Inbrija (levodopa inhalation powder) is the first and only inhaled levodopa, or L-dopa, for intermittent treatment of OFF episodes, also known as OFF periods, in people with Parkinson’s disease treated with carbidopa/levodopa regimen. Our New Drug Application, or NDA, for Inbrija was approved by the U.S. Food and Drug Administration, or FDA, on December 21, 2018. The approval is for a single dose of 84 mg (administered as two capsules), which may be taken up to five times per day. Inbrija became commercially available in the U.S. on February 28, 2019. Currently, Inbrija is available in the U.S. without the need for a medical exception for approximately 96% of commercial health insurance ~~plan~~plans and approximately ~~25%~~27% of Medicare plan lives. Net revenue for Inbrija was $7.8 million for the quarter ended September 30, 2021 and $5.8 million for the quarter ended September 30, ~~2020~~2020. Due to uncertainties caused by past and ~~$4.9 million for~~potential future impacts of the ~~quarter ended September 30, 2019. We project~~COVID-19 pandemic and other factors, we are no longer able to provide projected peak U.S. annual net revenue of Inbrija. Actual peak U.S. Inbrija net revenue will likely be lower and could be materially lower than our prior projected peak sales range if, for example, disruptions to ~~be in~~ the ~~range of $300 to $500 million.~~healthcare system caused by the COVID-19 pandemic or other prescribing challenges continue into 2022 and beyond.

European Union, or EU, convention, this reflects emitted dose and is equivalent to the 84 mg labelled dose in the U.S.). Under the MAA, Inbrija is indicated in the EU for the intermittent treatment of episodic motor fluctuations (OFF episodes) in adult patients with Parkinson’s disease treated with a levodopa/dopa-decarboxylase inhibitor. The MAA approved Inbrija for

use in what were then the 27 countries of the EU, as well as Iceland, Norway and Liechtenstein. Following the ratification of the Withdrawal Agreement between the United Kingdom and the EU, the UK left the EU on January 31, 2020. ~~However, this EU marketing authorization remains valid~~Effective January 1, 2021, Acorda was granted a grandfathered Marketing Authorization (MA) by the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK ~~during a transitional period~~subject to completion of an administrative process that ~~will end on December 31, 2020. After~~was approved by the MHRA in November 2021.

In July and November 2021, we announced that ~~date,~~ we ~~expect that EU law will cease~~entered into distribution and supply agreements with Esteve Pharmaceuticals to ~~apply~~commercialize Inbrija in Spain and toGermany, respectively. Under the ~~UK. The EU and the UK are currently negotiating a trade agreement, which would govern their future relationship after the end~~terms of the ~~transitional period. It is currently unclear whether~~Germany distribution agreement, we will receive a €5 million upfront payment, and we will receive additional sales-based milestones. Under the ~~parties can reach an agreement before December 31, 2020~~terms of both the Spain and ~~whether that agreement would also cover~~Germany supply agreements, we will receive a significant double-digit percent of the ~~regulation~~selling price of ~~medicinal products. Separately,~~Inbrija in exchange for supply of the ~~UK has indicated that it intends~~product. Esteve will have the exclusive distribution rights to ~~convert all valid EU marketing authorizations automatically into national marketing authorizations, unless~~Inbrija in Spain and Germany and we will supply the ~~marketing authorization holder objects.~~product to Esteve for sale. Esteve expects to launch Inbrija in Spain in the fourth quarter of 2022, and in Germany by mid-2022. We are in discussions with potential partners ~~regarding the distribution~~for commercialization of Inbrija in other jurisdictions outside of the U.S., ~~with potential partners~~including in Europe and ~~Japan.~~other countries.

We market Inbrija ~~is marketed~~ in the U.S. ~~through~~using field-based teams supported by our corporate marketing personnel. Our own specialty sales force and commercial infrastructure, and is distributed in the U.S. primarily through a network of specialty pharmacies, which deliver the medication to patients by mail, and ASD Specialty Healthcare, Inc. (an AmeriSource Bergen affiliate). We are in the process of transitioning from the network of several specialty pharmacies to a single specialty pharmacy for U.S. sales of Inbrija, which we believe has potential benefits to patients and our business. Our neuro-specialty sales ~~and marketing team includes our own~~representatives work in combination with sales representatives ~~as well as established teams of Medical Science Liaisons, Regional Reimbursement Directors,~~provided by a contract commercial organization, and Market Access Account Directors who provide information to payers and physicians on our marketed products; and Market Development Managers who work collaboratively with field teams and corporate personnel to assist in the execution of the Company’s strategic initiatives. Our sales representatives, which wecollectively they are ~~supplementing with contract sales representatives, are targeting approximately 5,000 healthcare providers,~~ currently ~~focusing~~focused on a priority list of approximately 2,000 physicians who are high volume prescribers of levodopa/carbidopa. Our field-based teams also include reimbursement and market access specialists, who provide information to physicians and payers on our marketed products, as well as market development specialists who work collaboratively with field-sales teams and corporate personnel to assist in the execution of our strategic initiatives. Our Inbrija ~~launch~~field-based and marketing activities ~~were initially~~are focused on physician awareness and market ~~access. We are maintaining these efforts while increasing focus on~~access as well as patient awareness, education and training. Inbrija is distributed in the U.S. primarily through: AllianceRx Walgreens Prime, or Walgreens, a specialty pharmacy that delivers the medication to patients by mail; and ASD Specialty Healthcare, Inc. (an AmeriSource Bergen affiliate).

We have established Prescription Support Services for Inbrija, which we sometimes refer to as the Inbrija hub. Prescription Support Services is designed to help patients navigate their insurance coverage and offer reimbursement support services, when appropriate. Services fall into one of these ~~four~~ categories: insurance verification, to research patient insurance benefits and confirm insurance coverage; prior authorization support, to identify prior authorization requirements; and appeals ~~support; and assistance identifying which specialty pharmacy a patient will utilize based on their insurance coverage.~~support. For patients that may need assistance paying for their medication, Prescription Support Services offers several support options, including: a program that provides no cost medication to patients who meet specific program eligibility requirements; co-pay support, which may help commercially insured (non-government funded) patients lower their out-of-pocket costs; and a bridge program, for federally-insured patients who experience a delay in coverage determination. We have ~~implemented~~ a no-cost sample program, available at physician offices, to enable patients and their physicians to assess the value of Inbrija before the patient incurs out-of-pocket co-pay or co-insurance costs. In addition, we have ~~implemented~~ a first dispense zero-dollar copay program for commercially-insured patients (which has replaced our previous free trial ~~program, available through~~program) to enable those patients to assess the value of Inbrija ~~hub, for commercially insured patients who cannot access the free samples because of offices and institutions that have policies that prohibit samples.~~before incurring out-of-pocket co-pay or co-insurance costs.

Parkinson’s disease is a progressive neurodegenerative disorder resulting from the gradual loss of certain neurons in the brain. These neurons are responsible for producing dopamine and that loss causes a range of symptoms including impaired movement, muscle stiffness and tremors. The standard baseline treatment of Parkinson’s disease is oral carbidopa/levodopa, but oral medication can be associated with wide variability in the timing and amount of absorption and there are significant challenges in creating a regimen that consistently maintains therapeutic effects. As Parkinson’s progresses, people are likely to experience OFF periods, which are characterized by the return of Parkinson’s symptoms that result from low levels of dopamine between doses of oral carbidopa/levodopa. OFF periods are often highly disruptive to people with Parkinson’s. Approximately one million people in the U.S. and 1.2 million Europeans are diagnosed with Parkinson’s; it is estimated that approximately 40% of people with Parkinson’s in the U.S. experience OFF periods.

Inbrija is for as needed use and utilizes our ARCUS platform for inhaled therapeutics. ARCUS is a dry-powder pulmonary drug delivery technology that we believe has potential to be used in the development of a variety of inhaled medicines. The ARCUS platform allows systemic delivery of medication through inhalation, by transforming molecules into a light, porous dry powder. This allows delivery of substantially higher doses of medication than can be delivered via conventional dry powder technologies. We acquired the ARCUS technology platform as part of our 2014 acquisition of Civitas Therapeutics. We have worldwide rights to our ARCUS drug delivery technology, which is protected by extensive

know-how and trade secrets and various U.S. and foreign patents, including patents that protect the Inbrija dry powder capsules beyond 2030. We have several patents listed in the Orange Book for Inbrija, including patents expiring between 2022 and 2032, and Inbrija is entitled to three years of new product exclusivity, through December 2021, as posted in the Orange book. We have patents in Europe for Inbrija expiring between 2022 and 2033. One of our European patents, EP 3090773B, has been opposed by an unnamed party. Inbrija also has 10 years of market exclusivity in Europe that is set to expire in 2029.

FDA and European Commission approvals of Inbrija were based on a clinical program that included approximately 900 people with Parkinson’s on a carbidopa/levodopa regimen experiencing OFF periods. The Phase 3 pivotal trial for Inbrija – SPAN-PD – was a 12-week, randomized, placebo controlled, double blind study evaluating the effectiveness of Inbrija in patients with mild to moderate Parkinson’s experiencing OFF periods. In January 2019, we announced that The Lancet Neurology published results from the SPAN-PD clinical trial.

The SPAN-PD trial met its primary endpoint, with patients showing a statistically significant improvement in motor function at the week 12 visit, as measured by a reduction in Unified Parkinson’s Disease Rating Scale (UPDRS) Part III score for Inbrija 84 mg (n=114) compared to placebo (n=112) at 30 minutes post-dose (-9.83 points and -5.91 points respectively; p=0.009). Onset of action was seen as early as 10 minutes. Maintenance of effect continued to 60 minutes post-dose, which is the longest time point assessed in the trial. UPDRS III is a validated scale, which measures Parkinson’s disease motor impairment.

The most common adverse reactions with Inbrija (at least 5% and greater than placebo) in the pivotal trial were cough (15% vs. 2%), upper respiratory tract infection (6% vs. 3%), nausea (5% vs. 3%) and discolored sputum (5% vs. 0%).

Inbrija was also studied in a Phase 3 long-term, active-controlled, randomized, open-label study (N=398) assessing safety and tolerability over one year. This study showed the average reduction in FEV1 (forced expiratory volume in 1 second) from baseline was the same (-0.1 L) for the Inbrija and observational cohorts. Patients with chronic obstructive pulmonary disease (COPD), asthma, or other chronic respiratory disease within the last five years were excluded from this study.

Inbrija is not to be used by patients who take or have taken a nonselective monoamine oxidase inhibitor such as phenelzine or tranylcypromine within the last two weeks.

Ampyra was approved by the FDA in January 2010 to improve walking in adults with multiple sclerosis. To our knowledge, Ampyra is the first drug approved for this indication. Efficacy was shown in people with all four major types of MS (relapsing remitting, secondary progressive, progressive relapsing and primary progressive). ~~Net revenue for~~ Ampyra ~~was $27.3 million for the quarter ended September 30, 2020 and $39.3 million for the quarter ended September 30, 2019.~~

~~We were previously engaged~~became subject to competition from generic versions of Ampyra starting in ~~litigation with certain generic drug manufacturers relating to our five initial Orange Book-listed Ampyra patents. In 2017, the United States District Court for the District~~late 2018 as a result of ~~Delaware issued a~~an adverse U.S. federal district court ruling that ~~upheld our~~invalidated certain Ampyra Orange Book-listed patent that expired on July 30, 2018, but invalidated our four other Orange Book-listed patents pertaining to Ampyra that were set to expire between 2025 and 2027. Under this decision, which was upheld on appeal in September 2018, our patent exclusivity with respect to Ampyra terminated on July 30, 2018. patents. We have experienced a significant decline in Ampyra sales due to competition from several generic versions of ~~Ampyra that have been marketed since we lost our appeal of the District Court decision.~~Ampyra. Additional manufacturers may market generic versions of Ampyra, and we expect our Ampyra sales will continue to decline over time.Net revenue for Ampyra was $20.0 million for the quarter ended September 30, 2021 and $27.3 million for the quarter ended September 30, 2020.

Ampyra is marketed as Fampyra outside the U.S. by Biogen International GmbH, or Biogen, under a license and collaboration agreement that we entered into in June 2009. Fampyra has been approved in a number of countries across Europe, Asia and the Americas. In May 2021, Biogen announced that Fampyra was approved by the National Medical Products Administration in China, and Biogen is evaluating commercial launch options in that country. Under our agreement with Biogen, we are entitled to receive double-digit tiered royalties on net sales of Fampyra and we are also entitled to receive additional payments based on achievement of certain regulatory and sales milestones. In October 2020, we received a $15 million milestone payment from Biogen based on ex-U.S. net sales exceeding $100 million over the four consecutive quarters ending with the third quarter of 2020. This payment was recorded as milestone revenue in the third quarter, but is not included in our third quarter-end cash balance because it was received in October 2020. We will retain approximately $14 million of the milestone payment net of our payment obligations to another party. In November 2017, we announced a $40 million Fampyra royalty monetization transaction with HealthCare Royalty Partners, or HCRP. In return for the payment to us, HCRP obtained the right to receive these Fampyra royalties up to an agreed-upon threshold. Until this threshold is met, ~~if ever,~~ we will not receive Fampyra royalties although we retained the right to receive any potential future ~~milestone payments, including the milestone payment described above. The HCRP~~

milestone payments. The HCRP transaction is accounted for as a liability, as described in Note 9 to our Consolidated Financial Statements included in this report.

~~Six issued Ampyra~~There are no patents ~~have been~~ listed in the Orange ~~Book. The five initial~~Book for Ampyra. Ampyra became subject to competition from generic versions of Ampyra starting in late 2018 as a result of an adverse U.S. federal district court ruling that invalidated certain Ampyra Orange Book-listed patents have been the subject of litigation with certain generic drug manufacturers, as described above. In connection with the litigation, our Orange Book-listed patent that expired on July 30, 2018, was upheld, but four other Ampyra patents set to expire between 2025 and 2027 were invalidated. At our request, these four patents have been delisted from the Orange Book. The sixth Orange Book-listed patent (U.S. Patent No. 9,918,973), set to expire in 2024, was more recently issued and was not involved in the litigation. At our request, this patent has also been delisted from the Orange Book. We note that this patent did not entitle us to any additional statutory stay of approval under the Hatch-Waxman Act against the generic drug manufacturers that were involved in the patent litigation described in this report.patents.

~~In 2011, the~~There are two European ~~Patent Office, or EPO, granted~~patents, EP 1732548 and EP 2377536, with claims ~~relating~~directed to ~~among other things,~~ use of a sustained release ~~aminopyridine~~dalfampridine composition ~~such as dalfampridine~~ (known under the trade name Fampyra in the European Union), to increase walking ~~speed. In March 2012, Synthon B.V. and neuraxpharm Arzneimittel GmBH filed oppositions~~speed in a patient with the EPO challenging the EP 1732548 patent. We defended the patent, and in December 2013, we announced that the EPO Opposition Division upheld amended claims in this patent covering a sustained release formulation of dalfampridine for increasing walking in patients with MS through twice daily dosing at 10 mg. Both Synthon B.V. and neuraxpharm Arzneimittel GmBH have appealed the decision. In December 2013, Synthon B.V., neuraxpharm Arzneimittel GmBH and Actavis Group PTC EHF filed oppositions with the EPO challenging our EP 2377536 patent, which is a divisional of the EP 1732548 patent. In February 2016, the EPO Opposition Division rendered a decision that revoked the EP 2377536 patent. We appealed the decision. In the Appeal Hearings in September 2019, the European Technical Board of Appeals upheld claims covering Fampyra in both the EP 1732548 patent and the EP 2377536 patent.multiple sclerosis. Both European patents are set to expire in 2025, absent any additional exclusivity granted based on regulatory review timelines. In June 2019, the EPO granted EP 2460521, which is a divisional of the EP 2377536 patent. In November 2019, we filed a request withdrawing our approval of the text on which EP 2460521 was granted, resulting in termination of the patent. Nullity actions have been filed in Germany against both of the German national patents derived from EP 1732548 and EP 2377536 by ratiopharm GmbH, a generic manufacturer affiliated with Teva. Fampyra ~~also has~~had 10 years of market exclusivity in the European Union that ~~is set to expire~~expired in July 2021.

We have been exploring opportunities for other proprietary products in which inhaled (pulmonary) delivery of medicine using our ARCUS drug delivery technology can provide a significant therapeutic benefit to patients. We believe there are potential opportunities with central nervous system, or CNS, as well as non-CNS, disorders.

Our ARCUS development ~~has~~had previously been focused on a program for acute treatment of migraine. Existing oral therapies for migraine can be associated with slow onset of action and gastrointestinal challenges. Patients cite the need for rapid relief from migraine symptoms as their most desired medication attribute. Additionally, individuals with migraine may suffer from nausea and delayed gastric emptying which further impact the consistency and efficacy of the oral route of administration. We ~~have~~had been evaluating therapeutic candidates for their suitability to move forward with this program. Due to ~~the restructuring described above~~several corporate restructurings since 2017 and associated cost-cutting measures, including the corporate restructurings we ~~have~~announced in January and September 2021, we deferred consideration of further investment into potential new ARCUS applications in migraine or any other indication pending additional progress with the Inbrija commercial launch in the U.S. Although we have deferred internal investment in ARCUS programs, we are discussing potential collaborations with other companies that have expressed interest in formulating their novel molecules for pulmonary delivery with ARCUS, and feasibility studies are ongoing for a number of these opportunities.

~~In July 2015,~~Should we decide to proceed with any ARCUS development programs, we would be reliant on Catalent or another third party supplier for the ~~Bill & Melinda Gates Foundation awarded us a grant~~manufacture of product for that program. Our global supply agreement with Catalent does not provide for the terms and conditions under which Catalent would supply any product or product candidate other than Inbrija. We would be unable to ~~support~~advance the development of ~~a formulation~~any ARCUS inhaled therapeutic candidate unless Catalent is willing to manufacture the candidate for us on commercially reasonable terms, or we could identify another third party manufacturer that would be capable and ~~delivery system~~willing to manufacture the candidate for ~~a dry powder version~~us on commercially reasonable terms.Also, due to reductions in force, employee attrition and the 2021 sale of ~~lung surfactant, a treatment~~our Chelsea manufacturing operations, we believe we lack certain personnel needed for, ~~neonatal respiratory distress syndrome, or nRDS. In collaboration~~and would need to hire replacements before continuing with, the Massachusetts Institute of Technology, we developed a formulation and delivery device based on our proprietary ARCUS drug delivery technology. nRDS is a condition affecting prematurely born infants in which their lungs are underdeveloped and thus lack a sufficient amount of lung surfactant. It can be fatal, or lead to severe, chronic health issues caused by a lack of oxygen getting to the baby’s brain and other organs. Delivering liquid surfactant to the lungs via intubation is the standard of care. We believe that our formulation and delivery system may present a more practical alternative for use in developing areas of the world, where intubation poses numerous problems. Based on recent achievement of pre-clinical proof of concept, the foundation has expanded the funding to include pre-IND development, including an additional grant of approximately $2.08 million in 2020 to continue this ~~work. This program is not aimed at developing a commercial product, but our work on this program (funding for which has not been impacted by the~~

~~restructuring) could potentially generate information that is useful for adapting the ARCUS drug delivery technology to commercial pediatric uses.~~

~~Our other~~ research and development programs include rHIgM22 and cimaglermin alfa. rHIgM22 is a remyelinating antibody that is a potential therapeutic for multiple sclerosis. Data from a Phase 1 safety and tolerability trial showed that a single dose of rHIgM22 was not associated with any safety signals. The study was not powered to show efficacy and exploratory measures showed no difference between the treatment groups. Cimaglermin alfa is a member of the neuregulin growth factor family, and has been shown to promote recovery after neurological injury, as well as enhance heart function in animal models of heart failure. We initiated a Phase 1b clinical trial assessing three doses of cimaglermin alfa in people with heart failure, but discontinued enrollment and then received an FDA clinical hold based on the occurrence of a case of hepatotoxicity (liver injury). The FDA clinical hold was lifted after we presented additional data on the hepatotoxicity, but we have not since restarted any clinical study of cimaglermin alfa. We are considering next steps for these programs, which could include potential partnering or out-licensing, but due to the restructuring described above and associated cost-cutting measures, we have deferred consideration of any further investment pending additional progress with the Inbrija commercial launch in the U.S.work.

We are providing the following guidance with respect to our ~~2020~~2021 financial performance:

The projected range of operating expenses in ~~2020~~2021 specified above was not prepared in accordance with accounting principles generally accepted in the United States (GAAP) because this guidance excludes restructuring costs and share-based compensation charges. Due to the forward looking nature of this information, the amount of compensation charges needed to reconcile this measure to the most directly comparable GAAP financial measure is dependent on future changes in the market price of our common stock and is not available at this time. Non-GAAP financial measures are not an alternative for financial

measures prepared in accordance with GAAP. However, we believe that the presentation of this non-GAAP financial measure, when viewed in conjunction with actual GAAP results, provides investors with a more meaningful understanding of our ongoing and projected operating performance because it excludes (i) expenses that pertain to ~~a non-routine restructuring,~~corporate restructurings that are not routine to the operation of our business, and (ii) non-cash charges that are substantially dependent on changes in the market price of our common stock. We believe this non-GAAP financial measure helps indicate underlying trends in our business and is important in comparing current results with prior period results and understanding expected operating performance. Also, our management uses this non-GAAP financial measure to establish budgets and operational goals, and to manage our business and to evaluate its performance.

Three-Month Period Ended September 30, ~~2020~~2021 Compared to September 30, ~~2019~~2020

For the three-month period ended September 30, 2020 we recognized product sales of Inbrija following receipt of product by companies in our distribution network, which primarily includes specialty pharmacy providers and ASD Specialty Healthcare, Inc. During the three-month period ended December 31, 2020, we completed the transition from a network of several specialty pharmacies to AllianceRx Walgreens Prime, or Walgreens, as the sole specialty pharmacy for U.S. sales of Inbrija, which we believe has potential benefits to patients and our business. We recognized net revenue from the sale of Inbrija of $7.8 million and $5.8 million for the three-month periods ended September 30, 2021 and 2020, respectively, an increase of $2.0 million or 34.4%. The increase in Inbrija net revenue was due to an increase in net volume of $3.3 million partially offset by discount and allowance adjustments of $1.3 million for the three-month period ended September 30, 2021.

Discounts and allowances which are included as an offset in net revenue consist of allowances for customer credits, including estimated chargebacks, rebates, returns and discounts. Discounts and allowances are recorded following shipment of our products to our customers. Adjustments are recorded for estimated chargebacks, rebates, and discounts. Discounts and allowances also consist of discounts provided to Medicare beneficiaries whose prescription drug costs cause them to be subject to the Medicare Part D coverage gap (i.e., the “donut hole”). Payment of coverage gap discounts is required under the Affordable Care Act, the health care reform legislation enacted in 2010. Discounts and allowances may increase as a percentage of sales as we enter into new managed care contracts in the future.

We believe that first and fourth quarter revenue for our products is subject to certain recurring seasonal factors relating to the commencement of a new calendar year. For example, some patients refill their prescriptions earlier ahead of the new year, in the fourth quarter, in anticipation of the year-end reset of health plan deductibles and the Medicare donut hole, or a year-end switch of their insurance plans or pharmacy benefit providers. Also, we believe that AllianceRx Walgreens Prime, the specialty pharmacy that we use for Inbrija distribution, may increase their Inbrija stock, within contractual limits, in anticipation of the holidays and new year. These factors may seasonally have a positive impact on fourth quarter revenues and a negative impact on first quarter revenues. Also, discounts and allowances typically are highest in the first quarter, and lowest in the fourth quarter, and when this occurs this increases fourth quarter revenues, and decreases first quarter revenues, on a relative basis.

allowances also consist of discounts provided to Medicare beneficiaries whose prescription drug costs cause them to be subject to the Medicare Part D coverage gap (i.e., the “donut hole”). Payment of coverage gap discounts is required under the Affordable Care Act, the health care reform legislation enacted in 2010. Discounts and allowances may increase as a percentage of sales as we enter into managed care contracts in the future.

We believe that first and fourth quarter revenue for our products is subject to certain recurring seasonal factors relating to the commencement of a new calendar year. For example, some patients refill their prescriptions earlier ahead of the new year, in the fourth quarter, in anticipation of the year-end reset of health plan deductibles and the Medicare donut hole, or a year-end switch of their insurance plans or pharmacy benefit providers. Also, we believe specialty pharmacies may increase their Ampyra stock in anticipation of the holidays and new year. These factors may seasonally have a positive impact on fourth quarter revenues and a negative impact on first quarter revenues. Also, discounts and allowances typically are highest in the first quarter, and lowest in the fourth quarter, and when this occurs this increases fourth quarter revenues, and decreases first quarter revenues, on a relative basis.

We recognized negligible revenue from the sale of other products for the three-month period ended September 30, 2021 as compared to $1.5 million for the three-month period ended September 30, 2020, a decrease of $1.5 million, or 98.6%.

We recognized $0 million and $15 million in milestone revenue for the three-month periods ended September 30, 2021 and 2020, respectively.

We recognized $3.6 million and $3.4 million in royalty revenue for the three-month periods ended September 30, 2021 and 2020, respectively, an increase of $0.2 million, or 5.9%.

We recorded cost of sales of $13.3 million for the three-month period ended September 30, 2021 as compared to $12.2 million for the three-month period ended September 30, 2020. Cost of sales for the three-month period ended September 30, 2021 consisted primarily of $13.0 million in inventory costs related to recognized revenues and $0.3 million in royalty fees based on net product shipments. Cost of sales for the three-month period ended September 30, 2020 consisted primarily of $8.8 million in inventory costs related to recognized revenues and $3.3 million in royalty fees based on net product shipments.

We recorded amortization of intangible asset related to Inbrija of $7.7 million for the three-month periods ended September 30, 2021 and 2020.

Research and development expenses for the three-month period ended September 30, 2021 were $1.9 million as compared to $5.7 million for the three-month period ended September 30, 2020, a decrease of approximately $3.8 million, or 66.7%. The decrease was primarily due to reductions in Civitas spending of $2.3 million due to the commercialization of Inbrija, reductions of $1.6 million due to restructuring and decrease in several programs to shift focus on Inbrija launch, partially offset by an increase of $0.1 million in research and development expenses.

Sales and marketing expenses for the three-month period ended September 30, 2021 were $14.5 million compared to $21.9 million for the three-month period ended September 30, 2020, a decrease of approximately $7.4 million, or 33.8%. The

decrease was primarily due to a decrease in marketing related spending of $5.9 million due to launch activities for Inbrija, and a decrease in overall salaries and benefits of $2.9 million, partially offset by a reclassification of departmental costs from general and administrative expenses of $1.4 million due to a change in the overhead expense allocation method.

General and administrative expenses for the three-month period ended September 30, 2021 were $15.1 million compared to $18.1 million for the three-month period ended September 30, 2020, a decrease of approximately $3.0 million, or 16.6%. The decrease was primarily due to an increase in legal expenses of $0.7 million and an increase of $2.2 million in restructuring costs, partially offset by a decrease in overall salaries and benefit costs of $3.7 million, a decrease in Civitas spending of $2.0 million due to the sale of the Chelsea facility manufacturing operations, and a decrease in other departmental spending of $0.2 million.

A derivative liability was recorded in December 2019 as a result of the issuance of the 6.00% Convertible Senior Secured Notes due 2024. The derivative liability is measured at fair value on a quarterly basis and changes in the fair value are recorded in the consolidated statement of operations. We recorded income of $0.3 million due to the change in the fair value of the derivative liability for the three-month period ended September 30, 2021.

As a result of the original spin out of Civitas from Alkermes, part of the consideration to Alkermes was a future royalty to be paid to Alkermes on Inbrija. Acorda acquired this contingent consideration as part of the Civitas acquisition. The fair value of that future royalty is assessed quarterly. We recorded a loss pertaining to changes in the fair value of our acquired contingent consideration of $2.2 million for the three-month period ended September 30, 2021 as compared to income of $23.6 million for the three-month period ended September 30, 2020. The changes in the fair-value of the acquired contingent consideration were primarily due to updates to certain revenue and expense forecast assumptions.

Other expense, net was $7.2 million for the three-month periods ended September 30, 2021 and 2020, respectively.

For the three-month periods ended September 30, 2021 and 2020, the Company recorded a benefit from income taxes of $3.1 million and a provision of $(1.5) million, respectively. The effective income tax rates for the Company for the three-month periods ended September 30, 2021 and 2020 were 10.2% and 16.6%, respectively.

The variance in the effective tax rates for the three-month period ended September 30, 2021 as compared to the three-month period ended September 30, 2020 was due primarily to an increase in the valuation allowance offset by the benefit of net operating loss carryback under the CARES Act recorded at 21% to recover taxes paid at the previous statutory rate of 35%.

The Company has ongoing state examinations in Massachusetts and New Jersey which cover multiple years. There have been no proposed adjustments at this stage of the examination.

The Minnesota examinations for 2016 and 2017 were closed during the quarter with no changes.

We recognize product sales of Inbrija following receipt of product by companies in our distribution network, which primarily includes specialty pharmacy providers and ASD Specialty Healthcare, Inc. We recognized net revenue from the sale of Inbrija of ~~$5.8~~$19.2 million and ~~$4.9~~$14.9 million for the ~~three-month~~nine-month periods ended September 30, ~~2020~~2021 and ~~2019,~~September 30, 2020, respectively, an increase of ~~$0.9~~$4.3 million, or ~~18.4%~~28.9%. The increase in Inbrija net revenue ~~increase is~~was due ~~primarily~~ to an increase in ~~sales activity in the three-month period ended September 30, 2020~~net volume of ~~$1.4~~$6.1 million ~~compared to the three-month period ended September 30, 2019,~~ partially offset by discount and allowance adjustments of ~~$0.5 million.~~

We recognize product sales of Ampyra following receipt of product by companies in our distribution network, which primarily includes specialty pharmacy providers. We recognized net revenue from the sale of Ampyra of $27.3 million and $39.3$1.8 million for the three-month periods ended September 30, 2020 and 2019, respectively, a decrease of $12.0 million, or 30.5%. The net revenue decrease is due primarily to a decrease in net volume of $15.3 million, partially offset by net price increase and discount and allowance adjustments of $4.8 million. Net revenue from sales of Ampyra decreased for the three-monthnine-month period ended September 30, ~~2020 compared to the three-month period ended September 30, 2019 due to the entry of generic versions of Ampyra as a result of the invalidation of certain of our Ampyra patents in 2017.~~2021.

We recognized net revenue from the sale of other products of $1.5 million for the three-month period ended September 30, 2020 as compared to $0.6 million for the three-month period ended September 30, 2019, an increase of $0.9 million, or 150%.

~~We recognized $15 million~~believe that first and ~~$0 million in milestone~~fourth quarter revenue for our products is subject to certain recurring seasonal factors relating to the ~~three-month periods ended September 30, 2020 and 2019, respectively. The increase~~ is ~~due to~~ commencement of a new calendar year. For example, some patients refill their prescriptions earlier ahead of the ~~$15 million milestone payment earned~~new year, in the ~~three-month period ended September 30, 2020 and received from Biogen~~fourth quarter, in ~~October 2020 based on ex-U.S. Fampyra net sales exceeding $100 million over a period of four consecutive quarters ending with the third quarter of 2020. We will retain approximately $14 million~~anticipation of the ~~milestone payment net~~year-end reset of ~~our payment obligations to another party.~~

~~We recognized $3.4 million~~health plan deductibles and ~~$2.9 million~~the Medicare donut hole, or a year-end switch of their insurance plans or pharmacy benefit providers. Also, we believe that AllianceRx Walgreens Prime, the specialty pharmacy that we use for Inbrija distribution, may increase their Inbrija stock, within contractual limits, in ~~royalty revenue for~~anticipation of the ~~three-month periods ended September 30, 2020~~holidays and ~~2019, respectively, an increase of $0.5 million, or 17.2%.~~

We recorded cost of sales of $12.2 million for the three-month period ended September 30, 2020 as compared to $8.0 million for the three-month period ended September 30, 2019. Cost of sales for the three-month period ended September 30, 2020 consisted primarily of $8.8 million in inventory costs related to recognizednew year. These factors may seasonally have a positive impact on fourth quarter revenues and ~~$3.3 million in royalty fees based~~a negative impact on ~~net product shipments. Cost of sales for the three-month period ended September 30, 2019 consisted primarily of $7.2 million in inventory costs related to recognized revenues~~first quarter revenues. Also, discounts and $0.2 million in royalty fees based on net product shipments and $0.5 million for costs related to sales of the authorized generic version of Ampyra. Cost of sales for inventory manufactured pre-launch for Inbrija was not recorded for the three-month period ended September 30, 2019, since the inventory manufactured ~~prior to the FDA approval~~ ~~was expensed~~ ~~as research and development expense as incurred and was combined with other research and development expenses in 2018.~~

~~We recorded amortization of intangible asset related to Inbrija of $7.7 million for the three-month periods ended September 30, 2020 and 2019.~~

Research and development expenses for the three-month period ended September 30, 2020 were $5.7 million as compared to $16.1 million for the three-month period ended September 30, 2019, a decrease of approximately $10.4 million, or 64.6%. The decrease was due primarily to reductions in Civitas spending of $7.2 million due to the commercialization of Inbrijaallowances typically are highest in the first quarter, of 2019, decreased spending on supply chain expansion, reductions in Ardsley spending of $3.1 million due to a continuing shift away from development activities related to earlier stage programs due to the Company’s focus on the Inbrija launch, partially offset by a reduction of $0.1 million in third party credits received related to program cancellations for Biotie that were recognizedand lowest in the ~~prior year.~~

~~Sales~~when this occurs this increases fourth quarter revenues, and marketing expenses for the three-month period ended September 30, 2020 were $21.9 million compared to $27.5 million for the three-month period ended September 30, 2019, a decrease of approximately $5.6 million, or 20.4%. The decrease was primarily due to a decrease in Inbrija spending of $0.6 million, a decrease in overall salaries and benefit costs of $3.1 million, and a decrease in Ampyra marketing related spending of $1.9 million.

General and administrative expenses for the three-month period ended September 30, 2020 were $18.1 million compared to $21.2 million for the three-month period ended September 30, 2019, a decrease of approximately $3.1 million, or 14.6%. The decrease was primarily due to a decrease in overall salaries and benefit costs of $2.2 million and a decrease in Civitas launch spending of $0.5 million, partially offset by an increase in other departmental spending of $0.3 million.

~~We recognized a goodwill impairment charge of $277.6 million in the three-month period ended September 30, 2019. During the third~~decreases first quarter of 2019, we experienced a significant decline in our stock price that reduced the market capitalization below the carrying value of the Company. We performed a quantitative assessment and after completing the assessment during the third quarter of 2019, we concluded that the carrying value of the Company exceeded its estimated fair value as of September 30, 2019 and therefore, the goodwill was fully impaired.

~~A derivative liability was recorded in December 2019 as a result of the issuance of the 6.00% Convertible Senior Secured Notes due 2024. The derivative liability is measured at fair value~~revenues, on a quarterly basis and changes in the fair value are recorded in the consolidated statement of operations. We recorded income of $4.9 million due to the change in the fair value of the derivative liability for the three-month period ended September 30, 2020.

As a result of the original Civitas spin out of Alkermes, part of the consideration to Alkermes was a future royalty to be paid to Alkermes on Inbrija. Acorda acquired this contingent consideration as part of the Civitas acquisition. The fair value of those future royalties is assessed quarterly. We recorded income pertaining to changes in the fair-value of acquired contingent consideration of $23.6 million for the three-month period ended ~~September~~ ~~30, 2020 as compared to $50.9 million for the three-month period ended~~ ~~September~~ ~~30, 2019.~~ ~~The changes in the fair-value of the acquired contingent consideration were primarily due to~~ ~~updates to certain product revenue and expense forecast assumptions, partially offset by a reduction in the discount rate and a reduction in the forecast periods for the passage of time~~.

~~Other expense, net was $7.2 million and $4.2 million for the three-month periods ended~~ ~~September~~ ~~30, 2020 and 2019, respectively.~~

On March 27, 2020, the CARES Act was signed into law, which enacted several tax favorable, business-related provisions. The Company reviewed the enacted provisions to determine which provisions should be considered for the three-month period ended ~~September~~ 30, 2020. Under the new law, the CARES Act provides that NOLs arising in a taxable year beginning after December 31, 2017, and before January 1, 2021, can be carried back to each of the five taxable years preceding the taxable year of such loss. The Company has considered the impact to the tax provision for the carryback of net operating losses to prior periods of taxable income incurred within the period allowed under the CARES Act. The result of carrying back these losses allowed the Company to realize certain deferred tax assets and a corresponding release of the valuation allowance of approximately $1.8 million. The Company received in July 2020, its U.S. income tax refund from the Internal Revenue Service of $12.7 million including interest, related to the 2019 net operating loss carryback. The Company recorded a tax receivable of $1.4 million for the anticipated 2020 net operating loss carryback claim as of ~~September~~ ~~30, 2020.~~

~~For the three-month periods ended~~ ~~September~~ 30, 2020 and 2019, the Company recorded a provision of ($1.5) million and ($0.02) million for income taxes, respectively. The effective income tax rates for the Company for the three-month periods ended ~~September~~ ~~30, 2020 and 2019 were 16.6% and 0%, respectively.~~

~~The variance in the effective tax rates for the three-month period ended~~ ~~September~~ ~~30, 2020 as compared to the three-month period ended~~ ~~September~~ 30, 2019 was due primarily to the valuation allowance recorded on deferred tax assets for which no tax benefit can be recognized, goodwill impairment for which no tax benefit can be recognized, and the benefit recorded on the net operating loss carryback under the CARES act recorded at 21% to recover taxes paid at the previous statutory rate of 35%.

~~The Company’s~~ state examination by the state of Massachusetts for the tax periods 2016 and 2017 was completed during the period ended September 30, 2020. The Company was assessed a tax of approximately $0.2 million.

We recognize product sales of Inbrija following receipt of product by companies in our distribution network, which primarily includes specialty pharmacy providers and ASD Specialty Healthcare, Inc. We recognized net revenue from the sale of Inbrija of $14.9 million and $9.2 million for the nine-month periods ended ~~September~~ 30, 2020 and September 30, 2019, respectively, an increase of $5.7 million, or 62.0%. The net revenue increase was due primarily to increased sales activity of $9.7 million, partially offset by discount and allowance adjustments of $4.0 million.relative basis.

We recognize product sales of Ampyra following receipt of product by companies in our distribution network, which primarily includes specialty pharmacy providers. We recognized net revenue from the sale of Ampyra of ~~$73.5~~$62.0 million and ~~$123.6~~$73.5 million for the nine-month periods ended September 30, ~~2020~~2021 and ~~2019,~~2020, respectively, a decrease of ~~$50.1~~$11.5 million, or ~~40.5%~~15.6%. The net revenue decrease is due primarily to decreased net volume of ~~$63.2~~$17.6 million partially offset by discount and allowance adjustments of ~~$13.7~~$6.4 million. Net revenue from sales of Ampyra decreased for the nine-month period ended September 30, ~~2020~~2021 compared to the nine-month period ended September 30, ~~2019~~2020 due to the entry of generic versions of Ampyra as a result of the invalidation of certain of our Ampyra patents in 2017.

Discounts and allowances which are included as an offset in net revenue consist of allowances for customer credits, including estimated chargebacks, rebates, returns and discounts. Discounts and allowances are recorded following shipment of our products ~~Inbrija and Ampyra~~ to our customers. Adjustments are recorded for estimated chargebacks, rebates, and discounts. Discounts and allowances also consist of discounts provided to Medicare beneficiaries whose prescription drug costs cause them to be subject to the Medicare Part D coverage gap (i.e., the “donut hole”). Payment of coverage gap discounts is required under the Affordable Care Act, the health care reform legislation enacted in 2010. Discounts and allowances may increase as a percentage of sales as we enter into managed care contracts in the future.

We believe that first and fourth quarter revenue for our products is subject to certain recurring seasonal factors relating to the commencement of a new calendar year. For example, some patients refill their prescriptions earlier ahead of the new year, in the fourth quarter, in anticipation of the year-end reset of health plan deductibles and the Medicare donut hole, or a year-end switch of their insurance plans or pharmacy benefit providers. Also, we believe specialty pharmacies may increase their Ampyra stock in anticipation of the holidays and new year. These factors may seasonally have a positive impact on fourth quarter revenues and a negative impact on first quarter revenues. Also, discounts and allowances typically are highest in the first quarter, and lowest in the fourth quarter, and when this occurs this increases fourth quarter revenues, and decreases first quarter revenues, on a relative basis.

We recognized ~~net~~negligible revenue from the sale of other products offor the nine-month period ended September 30, 2021 as compared to $1.7 million for the nine-month period ended September 30, ~~2020 as compared to $0.6 million for the nine-month period ended~~ ~~September~~ ~~30, 2019.~~2020.

We recognized ~~$15~~$0 million and $0$15 million in milestone revenue for the nine-month periods ended ~~September~~ ~~30, 2020 and 2019, respectively. The increase~~ is ~~due to~~ ~~the $15 million milestone payment earned in the three-month period ended~~ September 30, 2021 and 2020, and received from Biogen in October 2020 based on ex-U.S. Fampyra net sales exceeding $100 million over a period of four consecutive quarters ending with the third quarter of 2020. We will retain approximately $14 million of the milestone payment net of our payment obligations to another party.respectively.

We recognized ~~$9.7~~$10.8 million and ~~$8.6~~$9.7 million in royalty revenue for the nine-month periods ended September 30, 2021 and 2020, ~~and 2019,~~ respectively ~~an increase~~related to ex-U.S. sales of ~~$1.1 million, or 12.8%.~~Fampyra by Biogen.

We recorded cost of sales of $36.6 million for the nine-month period ended September 30, 2021 as compared to $22.7 million for the nine-month period ended September 30, ~~2020 as compared to $26.2 million for the nine-month period ended~~ ~~September~~ ~~30, 2019.~~2020. Cost of sales for the nine-month period ended September 30, 2021 consisted primarily of $34.4 million in inventory costs related to recognized revenues, $0.8 million in royalty fees based on net product shipments, idle capacity costs of $0.1 million, and $1.3 million in period costs related to expired inventory, freight, stability testing, and packaging. Cost of sales for the nine-month period ended September 30, 2020 consisted primarily of $18.6 million in inventory costs related to recognized revenues and $3.8 million in royalty fees based on net product shipments. Cost of sales for the nine-month period ended September 30, 2019 consisted primarily of $24.9 million in inventory costs related to recognized revenues, $0.7 million in royalty fees based on net product shipments and $0.5 million for costs related to sales of the authorized generic version of Ampyra. Cost of sales for inventory manufactured pre-launch for Inbrija was not recorded for the nine-month period ended ~~September~~ ~~30, 2019, since the inventory manufactured~~ ~~prior to the FDA approval~~ ~~was expensed~~ ~~as research and development expense as incurred and was combined with other research and development expenses in 2018.~~

We recorded amortization of intangible asset related to Inbrija of $23.1 million for the nine-month ~~period~~periods ended September 30, ~~2020 as compared to $17.9 million related to Ampyra for the nine-month period ended~~ 2021 and September 30, ~~2019.~~2020.

Research and development expenses for the nine-month period ended September 30, ~~2020~~2021 were ~~$18.7~~$9.1 million as compared to ~~$51.1~~$18.7 million for the nine-month period ended September 30, ~~2019,~~2020, a decrease of approximately ~~$32.4~~$9.6 million, or ~~63.4%~~51.3%. The decrease was due primarily to reductions in Civitas spending of ~~$23.8~~$4.9 million due to the commercialization of Inbrija, ~~in the first quarter~~reductions of ~~2019, decreased spending on supply chain expansion, reductions in Ardsley spending of $8.9~~$4.6 million due to ~~a continuing~~restructuring and decrease in several programs to shift ~~away from development activities related to earlier stage programs due to the Company’s~~ focus on ~~the~~ Inbrija launch, ~~partially offset by a reduction~~and reductions of ~~$0.3~~$0.1 million in ~~third party credits received related to program cancellations for Biotie that were recognized in the prior year.~~research and development expenses.

Sales and marketing expenses for the nine-month period ended September 30, ~~2020~~2021 were ~~$65.2~~$44.4 million compared to ~~$86.3~~$65.2 million for the nine-month period ended September 30, ~~2019,~~2020, a decrease of approximately ~~$21.1~~$20.8 million, or ~~24.4%~~31.9%. The decrease was attributable primarily to a decrease in overall salaries and benefits of ~~$10.6~~$7.9 million, ~~a decrease in spending related to marketing for Ampyra of $6.6 million, and~~ a decrease in Inbrija spending of ~~$3.9 million.~~$13.2 million, and a decrease in marketing for Ampyra of $1.1 million, partially offset by a reclassification of departmental costs from general and administrative expenses of $1.4 million due to a change in the overhead expense allocation method.

General and administrative expenses for the nine-month period ended September 30, ~~2020~~2021 were ~~$54.5~~$51.6 million compared to ~~$65.3~~$54.5 million for the nine-month period ended September 30, ~~2019,~~2020, a decrease of ~~approximately $10.8~~$2.9 million, or ~~16.5%~~5.3%. The decrease was primarily due to an increase in legal expenses of $4.9 million, an increase in restructuring costs of $4.0 million, and an increase of $1.3 million in other departmental spending, partially offset by a ~~reduction~~decrease in overall salaries and ~~benefits related~~benefit costs of ~~$8.0 million, decreased spending related to launch activities of $1.7~~$7.3 million and a decrease in ~~other departmental~~Civitas spending of ~~$0.9 million.~~$5.8 million due to the sale of the Chelsea facility manufacturing operations.

are recorded in the consolidated statement of operations. We recorded income of ~~$40.3~~$0.9 million due to the change in the fair value of the derivative liability for the nine-month period ended September 30, ~~2020.~~2021.

We recognized a goodwill impairment charge of $277.6 million in the nine-month period ended September 30, 2019. During the third quarter of 2019, we experienced a significant decline in our stock price that reduced the market capitalization below the carrying value of the Company. We performed a quantitative assessment and after completing the assessment during the third quarter of 2019, we concluded that the carrying value of the Company exceeded its estimated fair value as of September 30, 2019 and therefore, the goodwill was fully impaired.

As a result of the original Civitas spin out of Alkermes, part of the consideration to Alkermes was a future royalty to be paid to Alkermes on Inbrija. Acorda acquired this contingent consideration as part of the Civitas acquisition. The fair value of that future royalty is assessed quarterly. We recorded an income pertaining to changes in the fair-value of acquired contingent consideration of $4.2 million for the nine-month period ended September 30, 2021 as compared to $33.5 million for the nine-month period ended September 30, ~~2020 as compared to $56.3 million for the nine-month period ended September 30, 2019.~~ 2020. The changes in the fair-value of the acquired contingent consideration were primarily due to updates to certain product revenue and expense forecast ~~assumptions, partially offset by a reduction in the discount rate and a reduction in the forecast periods for the passage of time~~.assumptions.

Other expense, net was $22.7 million for the nine-month period ended September 30, 2021 as compared to $21.8 million for the nine-month period ended September 30, ~~2020 as compared to $13.0 million for the nine-month period ended September 30, 2019.~~2020. The change was due primarily to ~~an increase~~a decrease in ~~amortization~~gain on disposal of ~~debt discount expense~~property and equipment of ~~$6.5~~$0.2 million and a reduction in interest income of ~~$2.5~~$0.8 million, partially offset by a ~~gain on disposal~~decrease in amortization of ~~property and equipment~~debt discount expense of ~~$0.2.~~$0.1 million.

For the nine-month periods ended September 30, ~~2020~~2021 and ~~2019,~~2020, the Company recorded a benefit of ~~$5.0~~$6.8 million and a benefit of ~~$0.5~~$5.0 million for income taxes, respectively. The effective income tax rates for the Company for the nine-month periods ended September 30, 2021 and 2020 were 7.53% and ~~2019 were 23.1% and 0.14%~~23.07%, respectively. The variance in the effective tax rates for the nine-month period ended September 30, ~~2020~~2021 as compared to the nine-month period ended September 30, ~~2019~~2020 was due primarily to the valuation allowance recorded on deferred tax assets for which no tax benefit can be recognized, ~~goodwill impairment for which no tax benefit can be recognized,~~forfeitures of equity based awards and the benefit recorded on the net operating loss carryback under the CARES ~~act~~Act recorded at 21% to recover taxes paid at the previous statutory rate of 35%.

The Company has ongoing state examinations in Massachusetts and New Jersey which cover multiple years. There have been no proposed adjustments at this stage of the examination.

The ~~Company’s state examination by the state of~~ ~~Massachusetts~~Minnesota examinations for ~~tax periods~~ 2016 and 2017 ~~was completed~~were closed during the ~~period ended September 30, 2020. The Company was assessed a tax of approximately $0.2 million~~.quarter with no changes.

Since our inception, we have financed our operations primarily from: private placements and public offerings of our capital stock; borrowing money through loans and the issuance of debt instruments; payments received under our collaboration and licensing agreements; revenue from sales of Ampyra, Fampyra, and Inbrija, as well as our former products, Zanaflex and Qutenza; royalty monetizations and our revenue interest financing arrangement; and, to a lesser extent, funding from government grants. Also, in February 2021, we obtained additional capital from the sale of our Chelsea manufacturing operations.

At September 30, ~~2020,~~2021, we had ~~$63.3~~$36.2 million of cash and cash equivalents, ~~and short-term investments,~~ compared to ~~$125.8~~$71.4 million at December 31, ~~2019.~~2020. Our September 30, ~~2020~~2021 cash and cash equivalents ~~and short-term investments~~ balance does not include restricted cash, currently held in escrow under the terms of our convertible senior secured notes due 2024, further described below under Financing Arrangements, which may potentially be released from escrow if we pay interest on those notes using shares of our common stock. ~~In addition, we have~~We incurred a net ~~losses~~loss of ~~$16.5~~$83.4 million and ~~$273.0~~$99.6 million for the ~~nine months~~nine-month period ended September 30, ~~2020~~2021 and the year ended December 31, ~~2019, respectively.~~2020.

Based on our cash, cash equivalents and short-term investments at September 30, 2020, our recent net losses, and our obligations that are due within the next 12 months, including $69.0 million aggregate principal amount of our 2021 Notes that mature on June 15, 2021, our management has concluded that there is substantial doubt regarding our ability to meet our obligations within one year after the date the consolidated financial statements in this report are issued and, therefore, to continue as a going concern.

Our ability to meet our future operating requirements, repay our liabilities, and meet our other obligations ~~and continue as a going concern~~ are dependent upon a number of factors, including our ability to generate cash from product sales, reduce planned expenditures, and obtain additional financing. If we are unable to generate sufficient cash flow from the sale of our products, we may be required to adopt one or more alternatives, subject to the restrictions contained in the indenture governing our 2024 Notes, such as further reducing expenses, selling assets, restructuring debt, or obtaining additional equity capital on terms that may be onerous and which are likely to be highly dilutive. Also, our ability to raise additional capital

and repay or restructure our indebtedness will depend on the capital markets and our financial condition at such time, among other factors. In addition, financing may not be available when needed, at all, on terms acceptable to us or in accordance with the restrictions described above.

Due to these uncertainties, there is substantial doubt about the Company’s ability to continue as going concern. These unaudited condensed consolidated financial statements and accompanying notes have been prepared on the basis that the Company will continue as a going concern, and do not include any adjustments to reflect the possible future effects on the recoverability and classification of assets or the amounts and classification of liabilities that may result from the possible inability of the Company to continue as a going concern.

The 2024 Notes will mature on December 1, 2024 unless earlier converted in accordance with their terms prior to such date. Interest on the 2024 Notes ~~will be~~is payable semi-annually in arrears at a rate of 6.00% per annum on each June 1 and December 1, beginning on June 1, 2020. The Company may elect to pay interest in cash or shares of the Company’s common stock, subject to the satisfaction of certain conditions. If the Company elects to pay interest in shares of common stock, such common stock will have a per share value equal to 95% of the daily volume-weighted average price for the 10 trading days ending on and including the trading day immediately preceding the relevant interest payment date. In June 2021, the Company issued 1,635,833 shares of common stock in satisfaction of the interest payable to holders of the 2024 Notes on June 1, 2021. In connection with this stock-based interest payment approximately $6.2 million of accrued interest was released from restricted case and became available to the Company for other purposes.

Subject to a number of exceptions and qualifications, the 2024 Indenture restricts the ability of the Company and certain of its subsidiaries to, among other things, (i) pay dividends or make other payments or distributions on their capital stock, or purchase, redeem, defease or otherwise acquire or retire for value any capital stock, (ii) make certain investments, (iii) incur indebtedness or issue preferred stock, other than certain forms of permitted debt, which includes, among other items, indebtedness incurred to refinance the 2021 Notes, (iv) create liens on their assets, (v) sell their assets, (vi) enter into certain transactions with affiliates or (vii) merge, consolidate or sell of all or substantially all of their assets. The 2024 Indenture also requires the Company to make an offer to repurchase the 2024 Notes upon the occurrence of certain asset sales.

result, these features were aggregated together and recorded as the derivative liability conversion option. The conversion feature is measured at fair value on a quarterly basis and the changes in the fair value of the conversion feature for the period will be recognized in the consolidated statements of operations. ~~The Company performed a valuation of the derivative liability for the period ended~~ ~~September~~ 30, 2020 and determined that the fair value of the derivative liability was $19.1 million representing a change of $40.3 million that is recognized in the consolidated statement of operations for the nine-month period ended ~~September~~ ~~30, 2020.~~

The Company received stockholder approval on August 28, 2020 to increase the number of authorized shares of the Company’s common stock from ~~80,000,000~~13,333,333 shares to ~~370,000,000~~61,666,666 shares. As a result of the share approval, the Company determined that multiple embedded conversion options met the conditions for equity classification. The Company performed a valuation of these conversion options ~~for~~as of September 17, 2020, which was the ~~period ended September 30, 2020 and determined~~date the Company completed certain securities registration obligations. The resulting fair value of these conversion options was $18.3 million, which was reclassified to equity and presented in the statement of stockholder’s equity as of September 30, 2020, net of the $4.4 million tax impact. The equity component is not re-measured as long as it continues to meet the conditions for equity classification. The Company performed a valuation of the derivative liability related to certain embedded conversion features that are precluded from equity classification. The fair value of these conversion features was calculated to be ~~$0.8~~ $0.3 million, asrepresenting a change of $0.9 million that is recognized in the consolidated statement of operations for the nine-month period ended of September 30, ~~2020.~~2021.

The outstanding 2024 Note balance as of September 30 ~~30, 2020~~, 2021 consisted of the following:

In June 2014, the Company ~~entered into an underwriting agreement (the “Underwriting Agreement”) with J.P. Morgan Securities LLC (the “Underwriter”) relating to the issuance by the Company of~~issued $345 million aggregate principal amount of 1.75% Convertible Senior Notes due 2021 (the “2021 Notes”) in an underwritten public offering pursuant to the Company’s Registration Statement on Form S-3 (the “Registration Statement”) and a related preliminary and final prospectus supplement, filed with the SEC (the “Offering”). The principal amount of the 2021 Notes included $45 million aggregate principal amount of an underwriter option, which was exercised in full. The net proceeds from the offering, after deducting the Underwriter’s discount and the offering expenses paid by the Company, were approximately $337.5 million. On December 24, 2019, the Company completed the private exchange of $276.0 million aggregate principal amount of ~~its outstanding~~then-outstanding 2021 Notes for a combination of newly-issued 6.00% Convertible Senior Secured Notes due 2024 ~~(the “2024 Notes”)~~ and cash. ~~The 2021 Notes received by the Company in the exchange have been cancelled in accordance with their terms. As a result,~~Accordingly, upon completion of the exchange, $69.0 million of the 2021 Notes remained outstanding.

~~The~~ On June 15, 2021, Notes are governed by the terms of an indenture, dated as of June 23, 2014 (the “Base Indenture”) and the first supplemental indenture, dated as of June 23, 2014 (the “Supplemental Indenture,” and together with the Base Indenture, the “Indenture”), each between the Company ~~and Wilmington Trust, National Association, as trustee (the “Trustee”). The 2021 Notes will be convertible into cash, shares of~~repaid the Company’s common stock or a combination of cash and shares of the Company’s common stock, at the Company’s election, based on an initial conversion rate, subject to adjustment, of 23.4968 shares per $1,000 principal amount of 2021 Notes (representing an initial conversion price of approximately $42.56 per share), only in the following circumstances and to the following extent: (1) during the five business day period after any five consecutive trading day period (the “measurement period”) in which the trading price per $1,000 principal amount of 2021 Notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price of the Company’s common stock and the conversion rate on each such trading day; (2) during any calendar quarter commencing after the calendar quarter ending on September 30, 2014 (and only during such calendar quarter), if the last reported sale price of the common stock for at least 20 trading days (whether or not consecutive) during a period of 30 consecutive trading days ending on, and including, the last trading day of the immediately preceding calendar quarter is greater than or equal to 130% of the conversion price on each applicable trading day; (3) if the Company calls any or all of the 2021 Notes for redemption, at any time prior to the close of business on the scheduled trading day immediately preceding the redemption date; (4) upon the occurrence of specified events described in the Indenture; and (5) at any time on or after December 15, 2020 through the second scheduled trading day immediately preceding the maturity date.

~~The Company may redeem for cash all or part~~outstanding balance of the 2021 Notes at the Company’s option, after June 20, 2017 if the last reported sale price of the Company’s common stock has been at least 130% of the conversion price then in effect for at least 20 trading days (whether or not consecutive) during any 30 consecutive trading day period (including the last trading day of such period) ending within five trading days prior to thetheir maturity date on which the Company provides notice of redemption at a redemption price equal to 100% of the principal amount of the 2021 Notes to be redeemed, plus accrued and unpaid interest to, but excluding, the redemption date.

~~The Company will pay 1.75% interest per annum on the principal amount of the 2021 Notes, payable semiannually in arrears in~~using cash on ~~June 15 and December 15 of each year.~~hand.

~~such make-whole fundamental change, such holder may be entitled to an increase in the conversion rate as described in the Indenture.~~

The Indenture contains customary terms and covenants and events of default. If an event of default (other than certain events of bankruptcy, insolvency or reorganization involving the Company) occurs and is continuing, the Trustee by notice to the Company, or the holders of at least 25% in principal amount of the outstanding 2021 Notes by notice to the Company and the Trustee, may declare 100% of the principal of and accrued and unpaid interest, if any, on all the 2021 Notes to be due and payable. Upon such a declaration of acceleration, such principal and accrued and unpaid interest, if any, will be due and payable immediately. Upon the occurrence of certain events of bankruptcy, insolvency or reorganization involving the Company, 100% of the principal and accrued and unpaid interest, if any, on all of the 2021 Notes will become due and payable automatically. Notwithstanding the foregoing, the Indenture provides that, to the extent the Company elects and for up to 270 days, the sole remedy for an event of default relating to certain failures by the Company to comply with certain reporting covenants in the Indenture consists exclusively of the right to receive additional interest on the 2021 Notes.

In accounting for the issuance of the 2021 Notes, the Company separated the 2021 Notes into liability and equity components. The carrying amount of the liability component was calculated by measuring the fair value of a similar liability that does not have an associated convertible feature. The carrying amount of the equity component representing the conversion option was determined by deducting the fair value of the liability component from the par value of the 2021 Notes as a whole. The excess of the principal amount of the liability component over its carrying amount, referred to as the debt discount, is amortized to interest expense over the seven-year term of the 2021 Notes using the effective interest method. The equity component is not re-measured as long as it continues to meet the conditions for equity classification.

~~Our outstanding 2021 Note balances as of September 30, 2020 consisted of the following:~~

Non-convertible capital loans were granted by Business Finland (formerly Tekes), with an adjusted acquisition-date fair value of $20.5 million (€18.2 million) and a carrying value of ~~$27.0~~$28.0 million as of September 30 ~~30, 2020.~~, 2021. The loans are composed of fourteen non-convertible loans. The loans bear interest based on the greater of 3% or the base rate set by Finland’s Ministry of Finance minus one (1) percentage point. The maturity dates for these loans range from eight to ten years from the date of issuance, however, according to certain terms and conditions of the loans, the Company may repay the principal and accrued and unpaid interest of the loans only when the consolidated retained earnings of Biotie is sufficient to fully repay the loans.

Research and Development Loans (“R&D Loans”) were granted by Business Finland with an acquisition-date fair value of $2.9 million (€2.6 million) and a carrying value of ~~$0.6~~$0.0 million as of September 30 ~~30, 2020.~~, 2021. The R&D Loans bear interest based on the greater of 1% or the base rate set by Finland’s Ministry of Finance minus three (3) percentage points. The repayment of these loans began in January 2017. The loan principal is paid in equal annual installments over a 5 year period, ~~ending~~which ended January 2021.

At September 30, ~~2020,~~2021, cash and cash equivalents ~~and short-term investments~~ were approximately ~~$63.3~~$36.2 million, as compared to ~~$125.8~~$71.4 million at December 31, ~~2019.~~2020. Our cash equivalents consist of highly liquid investments with original maturities of three months or less at date of purchase and consist of investments in a Treasury money market fund. ~~Our short term investments consist of high-grade corporate debt securities, commercial paper and U.S. government securities with original maturities of twelve months or less at date of purchase.~~ Also, we maintain cash balances with financial institutions in excess of insured limits. We do not anticipate any losses with respect to such cash balances. Our September 30, ~~2020~~2021 cash and cash equivalents ~~and short-term investments~~ balance does not include restricted cash, currently held in escrow under the terms of our convertible senior secured notes due 2024, further described above under Financing Arrangements, which may potentially be released from escrow if we pay interest on those notes using shares of our common stock.

Net cash used in operations was ~~$62.5~~$44.6 million for the nine-month period ending September 30, ~~2020.~~2021. Cash used by operations for the nine-month period ended September 30, ~~2020~~2021 was primarily due to net loss of ~~$16.5~~$83.4 million, a change in acquired contingent consideration obligation of $4.2 million, non-cash royalty revenue of $8.9 million, deferred tax benefit of $6.8 million, a decrease in other non-current liabilities of $1.0 million, and a change in the derivative liability of ~~$40.3~~$0.9 million. This was partially offset by share based compensation expense of $2.5 million, amortization of debt discount and debt issuance costs of $12.7 million, depreciation and amortization of $25.5 million, an increase ~~in prepaid expenses and other assets of $16.7 million, a decrease~~ in accounts payable, accrued expenses and other current liabilities of $13.4 million, a change in acquired contingent consideration liability of $33.5 million and non-cash royalty revenue of $8.5 million. This was partially offset by depreciation and amortization of $30.9$4.9 million, a decrease in accounts receivable of ~~$8.7~~$6.6 million, a ~~deferred tax provision~~decrease in inventory of ~~$8.8 million, amortization of debt discount and debt issuance costs of $12.2~~$5.8 million, and ~~share based compensation expense~~a decrease in prepaid expenses and other assets of ~~$6.5~~$2.6 million.

Net cash ~~provided by~~used in investing activities for the nine-month period ended September 30, ~~2020~~2021 was ~~$54.3~~$0.2 million, which was due primarily to ~~proceeds from maturity of investments of $58.4 million, partially offset by~~ purchases of property and equipment and intangible assets of ~~$4.1~~$0.2 million.

Net cash ~~used in~~provided by financing activities for the nine-month period ended September 30, ~~2020~~2021 was ~~$1.7~~$4.3 million, which was primarily due to net proceeds from the sale of the Chelsea facility of $74.0 million, partially offset by the repayment of Convertible Senior Notes due in June 2021 of $69.0 million, and the repayment of loans payable of ~~$0.6 million and debt issuance costs of $1.1~~$0.7 million.

A summary of our minimum contractual obligations related to our material outstanding contractual commitments is included in Note 1413 of our Annual ~~report~~Report on Form 10-K for the year ended December 31, ~~2019.~~2020. Our long-term contractual obligations include commitments and estimated purchase obligations entered into in the normal course of business.

Under certain agreements, we are required to pay royalties or license fees and milestones for the use of technologies and products in our ~~R&D~~research and development activities and in the commercialization of products. The amount and timing of any of the foregoing payments are not known due to the uncertainty surrounding the successful research, development and commercialization of the products. ~~During the nine-month period ended September 30, 2020, commitments related to the purchase of inventory decreased as compared to December 31, 2019.~~ As of September 30, ~~2020,~~2021, we have inventory-related purchase commitments ~~totaling~~of approximately $0.7 million, as compared to $2.5 ~~million.~~million as of September 31, 2020. Under our agreement with Catalent, we are obligated to make minimum purchase commitments for Inbrija through the expiration of the agreement on December 31, 2030. As of September 30, 2021, the minimum remaining purchase commitment to Catalent was $4 million through December 31, 2021, and $18 million annually each year thereafter.

Our critical accounting policies are detailed in our Annual Report on Form 10-K for the year ended December 31, ~~2019.~~ 2020. Effective January 1, ~~2020,~~2021, the Company adopted ASU ~~2016-13, “Financial Instruments – Credit Losses” (Topic 326), ASU 2018-13,~~ ~~“Fair Value Measurement (Topic 820), ASU 2018-15,~~ ~~“Customer’s~~2019-12, “Simplifying the Accounting for ~~Implementation Costs Incurred in a Cloud Computing Arrangement That is a Service Contract”, and,~~ Income Taxes” (Topic 740).~~ASU 2018-18,~~ ~~“Collaborative Arrangements” (Topic 808).~~ Other than the adoption of the new accounting guidance, our significant accounting policies have not changed materially from December 31, ~~2019~~2020.

Our financial instruments consist of cash equivalents, short-term investments, accounts receivable, convertible notes payable, senior notes, liability related to the sale of future royalties, and accounts payable. The estimated fair values of all of our financial instruments approximate their carrying values at September 30, 2020, except for the fair valueWe are a smaller reporting company as defined by Rule 12b-2 of the ~~Company’s convertible senior notes due 2021, which was approximately $55.3 million as of September 30, 2020,~~Exchange Act and are not required to provide the ~~Company’s convertible senior secured notes due 2024, which was approximately $119.3 million as of September 30, 2020.~~information otherwise required under this item.

We have cash equivalents and short-term investments at September 30, 2020, which are exposed to the impact of interest rate changes and our interest income fluctuates as our interest rates change. Due to the nature of our investments in money market funds, high-grade corporate bonds, and commercial paper, the carrying value of our cash equivalents and short-term investments approximate their fair value at September 30, 2020. At September 30, 2020, we held $63.3 million in cash, cash equivalents and short-term investments which had an average interest rate of approximately 2.2%. This amount excludes the restricted cash held in escrow related to the 6% semi-annual interest payments due on the convertible senior secured notes due 2024.

We maintain an investment portfolio in accordance with our investment policy. The primary objectives of our investment policy are to preserve principal, maintain proper liquidity and to meet operating needs. Although our investments are subject to credit risk, our investment policy specifies credit quality standards for our investments and limits the amount of credit exposure from any single issue, issuer or type of investment. Our investments are also subject to interest rate risk and will decrease in value if market interest rates increase. However, due to the conservative nature of our investments and relatively short duration, interest rate risk is mitigated. We do not own derivative financial instruments. Accordingly, we do not believe there is any material market risk exposure with respect to derivative or other financial instruments.

As required by Rule 13a-15 under the Securities Exchange Act of 1934 (the Exchange Act) we carried out an evaluation of the effectiveness of our disclosure controls and procedures as defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act, as of the end of the third quarter of ~~2020,~~2021, the period covered by this report. This evaluation was carried out under the supervision and with the participation of our management, including our President and Chief Executive Officer and our Chief ~~Business Operations and Principal Accounting~~Financial Officer. Based on that evaluation, these officers have concluded that, as of September 30, ~~2020,~~2021, our disclosure controls and procedures were effective to achieve their stated purpose.

Disclosure controls and procedures are controls and other procedures that are designed to ensure that information required to be disclosed in our reports filed or submitted under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules, regulations, and forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed in our reports filed or submitted under the Exchange Act is accumulated and communicated to management, including our ~~Chief Executive Officer~~principal executive and ~~Chief, Business Operations and Principal Accounting Officer,~~principal financial officers, as appropriate to allow timely decisions regarding disclosure.

In connection with the evaluation required by Exchange Act Rule 13a-15(d), our management, including our President and Chief Executive Officer and our Chief ~~Business Operations and Principal Accounting~~Financial Officer, concluded that there were no changes in our internal control over financial reporting during the quarter ended September 30, ~~2020,~~2021, that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

Our disclosure controls and procedures are designed to provide reasonable, not absolute, assurance that the objectives of our disclosure control system are met. Because of inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that all control issues, if any, within a company have been detected.

From time to time, we may be involved in litigation or other legal proceedings relating to claims arising out of operations in the normal course of our ~~business.~~business, including the DRI matter described below. The outcome of litigation and other legal proceedings is unpredictable, and regardless of outcome, they can have an adverse impact on us because of defense and settlement costs, diversion of management resources, and other factors.

On November 9, 2020, Drug Royalty III, L.P., and LSRC III S.ar.l. (collectively, “DRI”) filed an arbitration claim against us with the American Arbitration Association under a September 26, 2003 License Agreement that we originally entered into with Rush-Presbyterian St. Luke’s Medical Center (“Rush”). DRI previously purchased license royalty rights under the license agreement from Rush. DRI alleges a dispute over the last-to-expire patent covering sales of the drug Ampyra under the license agreement, and is claiming damages based on unpaid license royalties of $6 million plus interest. We believe we have valid defenses against this claim and intend to defend ourselves vigorously.

Item 1 of Part II of our Quarterly Reports on Form 10-Q for the quarters ended March 31, 2021 and June 30, 2021 include prior updates to the legal proceeding described above.

In addition to the other information set forth in this report, you should carefully consider the risk factors discussed in Part I, Item 1A. Risk Factors, in our Annual Report on Form 10-K for the year ended December 31, ~~2019,~~2020, as updated in our Quarterly Reports subsequently filed during the current fiscal year, including this report, all of which could materially affect our business, financial condition and/or ~~future~~operating results. These risks are not the only risks facing our Company. Additional risks and uncertainties not currently known to us or that we currently deem to be immaterial also may materially adversely affect our business, financial condition and/or operating results.

Following is the restated text of certain risk ~~factors to report~~factor changes since our publication of risk factors in our ~~2019~~2020 Annual Report on Form 10-K and our Quarterly Reports on Form 10-Q for the ~~first~~quarters ended March 31, 2021 and ~~second quarters of 2020.~~June 30, 2021.

Our ~~ability~~restructurings and associated organizational changes may not adequately reduce our expenses, may lead to ~~continue~~additional workforce attrition, and may cause operational disruptions.

In January and September 2021, we implemented corporate restructurings to reduce costs, more closely align operating expenses with expected revenue, and focus our resources on Inbrija (levodopa inhalation powder). As part of these restructurings, we substantially reduced employee headcount. Further restructuring activities may be required in the future, depending in particular on the rate of decline in our sales of Ampyra due to generic competition and whether we are able to sufficiently increase sales of Inbrija. Our restructurings may have other unintended consequences as well, including, for example, making it more difficult for us to attract and retain highly skilled personnel in a ~~going concern is dependent~~competitive environment (particularly given that we have implemented four corporate restructurings since 2017). We have recently experienced workforce attrition in various functions across our business, which may be attributable to our corporate restructurings, our current business circumstances, a combination of both, or other factors. Our efforts to adjust our operations with the reduced workforce may not be successful in preventing disruption to our business, and with the reduced workforce we lack redundancy in important functions across our business. We are increasingly relying on the services of a ~~significant amount~~contract commercial organization to provide sales representatives in response to substantial sales force attribution. Further loss of ~~cash required~~one or more of our key employees, additional loss of multiple employees in particular functions, and/or our inability to attract replacement or additional qualified personnel could substantially impair our ability to operate our business and ~~service~~implement our ~~debt,~~business plan, particularly our efforts to successfully commercialize Inbrija.

Our inability to attract and retain key management and other personnel, or maintain access to expert advisors, may hinder our ability to execute our business plan.

We are highly dependent on the services of Dr. Ron Cohen, our President and Chief Executive Officer, as well as the other principal members of our management and scientific, regulatory, and commercial personnel. Our success depends in large part upon our ability to ~~obtain additional funding~~attract and retain highly qualified personnel with the knowledge and experience needed for these

and other areas of our business. We do not maintain "key man" life insurance policies on the lives of our officers, directors or employees.

We face intense competition in ~~the future;~~our hiring efforts with other pharmaceutical and biotechnology companies, as well as universities and nonprofit research organizations. We may be unable to attract or retain qualified personnel because their competitive salaries and other compensation may increase to levels that we ~~may not have sufficient cash flow from~~are unwilling or unable to provide. In addition, material adverse developments with our business, ~~to continue to sufficiently fund our operations and pay our substantial debt,~~ including the ~~remainder~~2017 adverse patent decision relating to our Orange Book-listed Ampyra patents, the termination or suspension of research and development programs, four reductions in force since 2017, and the current progress of our ~~convertible senior notes that mature in June 2021.~~

~~We will need to expend substantial resources forcommercialization of our marketed products, including costs associated with the commercialization of Inbrija. In addition,~~Inbrija commercial launch, may impede our ability to ~~make scheduled payments~~attract and retain highly qualified personnel. We have recently experienced workforce attrition in various functions across our business, which may be attributable to one or more of the ~~principal~~factors described above or other factors. Our efforts to adjust our operations with the reduced workforce may not be successful in preventing disruption to our business, and with the reduced workforce we lack redundancy in important functions across our business. We are increasingly relying on the services of a contract commercial organization to ~~pay interest on,~~provide sales representatives in response to substantial sales force attribution. Further loss of one or ~~to refinance our indebtedness, including our convertible senior secured notes due 2024 and the remaining portion~~more of our ~~convertible senior notes that matures~~key employees, additional loss of multiple employees in ~~June~~particular functions, and/or our inability to attract replacement or additional qualified personnel could substantially impair our ability to operate our business and implement our business plan, particularly our efforts to successfully commercialize Inbrija. Also, due to the recent attrition, four reductions in force since 2017, and our 2021 ~~depends on~~sale of our ~~future performance, which is subject~~Chelsea manufacturing operations, we believe we lack personnel needed for, and would need to ~~economic, financial, competitive~~hire replacements before continuing with, research and development and clinical programs. Our inability to attract qualified replacements needed for research and development and clinical programs could substantially impair our ability to advance those programs, if we determine to make further investments in those programs.

We also have scientific, medical, clinical, marketing and other ~~factors beyond our control. Our business may not continue to generate cash flow from operations~~advisors who assist us in ~~the future sufficient to support our operations and service our debt and make necessary capital expenditures. Also,~~ our research and development, ~~programs will~~clinical, and commercial strategies. These advisors are not ~~generate any revenues for the foreseeable future, if ever, because~~our employees and may have commitments to, or consulting or advisory contracts with, other entities that may limit their availability to us. Similarly, they ~~are all in early stages, pharmaceutical development is subject~~may have arrangements with other companies to numerous risks including those described elsewhere in these risk factors, and generally we have discontinued funding our research and development pending additional progress with the Inbrija commercial launchassist in the ~~U.S. As a result~~development and commercialization of ~~these conditions, we have concluded~~products that ~~there is substantial doubt~~may compete with ours.

This table provides information about our ~~ability to meet our obligations within one year after~~purchases of shares of Company stock during the ~~date the consolidated financial statements in this third quarter report are issued and, therefore, to continue as a going concern.~~three-month period ended September 30, 2021.

Our ability to meet our future operating requirements, repay our liabilities, meet our other obligations, and continue as a going concern are dependent upon a number of factors, including our ability to generate cash from product sales, reduce planned expenditures, and obtain additional financing. If we are unable to generate sufficient cash flow from the sale of our products, we will be required to adopt one or more alternatives, subject to the restrictions contained in the indenture governing our convertible senior secured notes due 2024, such as further reducing expenses, selling assets, restructuring debt, or obtaining additional equity capital on terms that may be onerous and which are likely to be highly dilutive. Also, our ability to raise additional capital and repay or restructure our indebtedness will depend on the capital markets and our financial condition at such time, among other factors. In addition, financing may not be available when needed, at all, on terms acceptable to us or in accordance with the restrictions described above. Furthermore, a determination that there is substantial doubt about a company’s ability to continue as a going concern is generally viewed unfavorably by current and prospective investors, as well as by analysts and creditors. As a result of these factors, we may not be able to engage in any of the alternative activities, or engage in such activities on desirable terms, which could harm our business, financial condition and results of operations, as well as result in a default on our debt obligations. If we are unable to take these actions, we may be forced to significantly alter our business strategy, substantially curtail our current operations, or cease operations altogether.

The commercial success of Inbrija (levodopa inhalation powder) and any other future products are highly dependent on market acceptance among physicians, patients and the medical community, adequate reimbursement by government and other third-party payers, and other factors.

We face significant challenges in successfully commercializing our approved pharmaceutical products, including Inbrija. Generally, market acceptance of our products depends on the benefits of our products in terms of safety, efficacy, convenience, ease of administration and cost effectiveness and our ability to demonstrate these benefits to physicians, patients and third-party payers. Commercial success requires significant investment in sales, marketing and market access efforts, and is dependent on how well we develop and implement strategies for these efforts. Commercial success is also subject to numerous other risks, including those described below, some of which are described in further detail elsewhere in these risk factors:

~~Also, in the U.S., the federal government provides funding for comparative effectiveness research, which may compare~~Item 5. Other Information

On November 12, 2021, Dr. Ron Cohen, our ~~products with other treatments~~President and ~~may result in published findings that would, in turn, discourage use~~CEO, was granted options to purchase 100,000 shares of our ~~products by physicians and payments for~~common stock under our ~~products by payers. Similar research is funded in other countries, including in some countries in Europe.~~

2015 Omnibus Incentive Compensation Plan. The ~~failure of any~~stock options have an exercise price equal to the closing price of our ~~products or product candidates, once approved, to achieve~~common stock on the grant date, vest over four years from the grant date in equal quarterly installments, and have a 10 year term. Our Board awarded these stock options after considering the current value of Dr. Cohen’s equity awards in light of the current market ~~acceptance would limit our ability to generate revenue and would harm our results of operations and could adversely affect our future prospects. If market acceptance~~price of our ~~products~~common stock, and also reductions to Dr. Cohen’s compensation implemented in connection with our recent corporate restructuring. Based on these considerations, the ~~U.S., EU, or other countries does not meet expectations,~~Board awarded Dr. Cohen these options as an incentive to better align his long-term interests with those of our ~~revenues or royalties from product sales would suffer~~stockholders and ~~this could cause our stock price to decline or could otherwise adversely affect our stock~~for

~~The identification~~retention of new side effects from Inbrija (levodopa inhalation powder) or any other marketed drug products, or side effects from those products that are more frequent or severe than in the past, would harm our business and could lead to a significant decrease in sales or to the withdrawal of marketing approval in the U.S. and/or in other jurisdictions.

Based on our clinical trials, the most common adverse reactions with Inbrija (at least 5% and greater than placebo) include cough, upper respiratory tract infection, nausea and discolored sputum. We constantly monitor Inbrija adverse event reports for signals regarding potential additional adverse events.

~~If we or others identify previously unknown side effects, if known side effects are more frequent or severe than in the past,or if we or others detect unexpected safety signals for Inbrija or any products perceived to be similar to Inbrija, then in any of these circumstances:~~

~~The above occurrences could impair our business by harming or possibly preventing sales of Inbrija, causing sales to fall below projections, and increasing our expenses.~~

We rely on specialty pharmacies to dispense our products, deliver customer support, and provide us with related services, and our business could be harmed and we could be subject to liabilities if these services are performed inadequately or in a manner that does not comply with applicable laws and regulations.

A specialty pharmacy is a pharmacy that specializes in the dispensing of injectable, infused or certain other medications typically for complex or chronic conditions, including Parkinson’s disease and multiple sclerosis, which often require a high level of patient education and ongoing management. Most of our Inbrija and Ampyra sales are sold through specialty pharmacies, and sales of these products are highly dependent on the performance of these specialty pharmacies.

~~The use of specialty pharmacies involves risks, including, but not limited to, risks that these specialty pharmacies:~~

If our specialty pharmacies do not fulfill their contractual obligations to us or fail to adequately dispense our products and deliver customer support, our product sales and business could be harmed or we could be subject to legal or regulatory liabilities or sanctions. Also, for U.S. sales of Inbrija, we are in the process of transitioning from a network of several specialty pharmacies to a single specialty pharmacy. While we believe this change has potential benefits to patients and our business, reliance on a single specialty pharmacy also potentially increases the risks described above because we would not have a backup specialty pharmacy to dispense Inbrija and provide related services if an issue arises with the single specialty pharmacy. We expect that it would take a significant amount of time if we were required to change from the single specialty pharmacy.

~~Furthermore, arrangements between manufacturers and specialty pharmacies can be subject to government scrutiny and challenge under fraud and abuse laws if not structured properly.~~

If our competitors develop and market products that are more effective, safer or more convenient than our approved products, or obtain marketing approval before we obtain approval of future products, our commercial opportunityhis employment. These options will be ~~reduced or eliminated.~~

~~Competition~~taken into account by the Board in the pharmaceutical and biotechnology industries is intense and is expected to increase. Many biotechnology and pharmaceutical companies, as well as academic laboratories, are involved in research and/or product development for various neurological conditions, including Parkinson’s disease, or PD, and multiple sclerosis, or MS.

Our competitors may succeed in developing products that are more effective, safer or more convenient than our products or the ones we have under development or that render our approved or proposed products or technologies noncompetitive or obsolete. In addition, our competitors may achieve product commercialization before we do. Ifconnection with any ~~of our competitors develops a product~~annual equity award program that is more effective, safer or more convenient for patients, or is able to obtain FDA approval for commercialization before we do, we may not be able to achieve market acceptance for our products, which would harm our ability to generate revenues and recover the substantial development costs we have incurred and will continue to incur.

Our products may be subject to competition from lower-priced versions of such products and competing products imported into the U.S. from Canada, Mexico and other countries where there are government price controls or other market dynamics that cause the products to be priced lower.

~~Inbrija (levodopa inhalation powder)/Parkinson’s Disease~~. Inbrija competes against other therapies approved for intermittent, or as needed, use that aim to specifically address Parkinson’s disease symptoms. Apokyn, an injectable formulation of apomorphine, is approved for the treatment of OFF periods, also known as OFF episodes. Apokyn was approved for this useimplemented in the U.S. in 2004 and in Europe in 1993. Also, Sunovion Pharmaceuticals Inc. has developed a sublingual, or under the tongue, formulation of apomorphine branded as Kynmobi that we expect to be competitive with Inbrija. Sunovion received FDA approval for Kynmobi in May 2020 for the acute, intermittent treatment of OFF episodes, and Kynmobi became available in the U.S. in September 2020.2022.

The standard of care for the treatment of Parkinson’s disease is oral carbidopa/levodopa, but oral medication can be associated with wide variability in the timing and the amount of absorption and there are significant challenges in creating a regimen that consistently maintains therapeutic effects as Parkinson’s disease progresses. Inbrija may face competition from therapies that can limit the occurrence of OFF periods. Approaches to achieve consistent levodopa plasma concentrations include new formulations of carbidopa/levodopa, such as extended-release and intestinal infusions, and therapies that prolong the effect of levodopa. Amneal Pharmaceuticals, Inc. (formerly Impax Laboratories) markets RYTARY, an extended-release formulation of oral carbidopa/levodopa, and extended release formulations of oral and patch carbidopa/levodopa are being developed by others including Intec Pharma and Mitsubishi Tanabe Pharma Corporation. Also, Abbvie Inc. has developed a continuous administration of a gel-containing levodopa through a tube that is surgically implanted into the intestine. This therapy, known as Duopa, has been approved by the FDA and is approved in the EU.

~~One or more of our competitors may utilize their expertise in pulmonary delivery of drugs to develop and obtain~~

approval for pulmonary delivery products that may compete with Inbrija and any other of our other ARCUS drug delivery technology product candidates. These competitors may include smaller companies such as Alexza Pharmaceuticals, Inc., MannKind Corporation, Pulmatrix, Inc. and Vectura Group plc and larger companies such as Allergan, Inc., GlaxoSmithKline plc and Novartis AG, among others. If approved, our product candidates may face competition in the target commercial areas for these pulmonary delivery products. Also, we are aware that at least one company, Impel Neuropharma, is developing intranasally delivered levodopa therapies which, if approved, might compete with Inbrija.

~~Ampyra/MS.~~ Ampyra has become subject to competition from generic drug manufacturers. We were previously engaged in litigation with certain generic drug manufacturers relating to our five initial Orange Book-listed Ampyra patents. In 2017, the United States District Court for the District of Delaware (the “District Court”) issued a ruling that upheld our Ampyra Orange Book-listed patent that expired on July 30, 2018, but invalidated our four other Orange Book-listed patents pertaining to Ampyra that were set to expire between 2025 and 2027. Under this decision, our patent exclusivity with respect to Ampyra terminated on July 30, 2018. We appealed the District Court decision to the United States Court of Appeals for the Federal Circuit, or the Federal Circuit, which issued a ruling in September 2018 upholding the District Court’s decision (the “Appellate Decision”). In January 2019, the Federal Circuit denied our petition for rehearing en banc. In October 2019, the U.S. Supreme Court denied our petition for certiorari requesting review of the case. We have experienced a significant decline in Ampyra sales due to competition from generic versions of Ampyra that are being marketed following the Appellate Decision. Additional manufacturers may market generic versions of Ampyra, and we expect our Ampyra sales will continue to decline over time.

Current disease management approaches to MS are classified either as relapse management, disease course management, or symptom management approaches. For relapse management, the majority of neurologists treat sudden and severe relapses with a four-day course of intravenous high-dose corticosteroids. Many of these corticosteroids are available generically. For disease course management, there are a number of FDA-approved MS therapies that seek to modify the immune system. These treatments attempt to reduce the frequency and severity of exacerbations or slow the accumulation of physical disability for people with certain types of MS, though their precise mechanisms of action are not known. These products include Avonex, Tysabri, Plegridy and Tecfidera from Biogen, Betaseron from Bayer AG, Copaxone from Teva Pharmaceutical Industries, Ltd., Rebif from Merck Serono, Gilenya and Extavia from Novartis AG, Aubagio and Lemtrada from Genzyme Corporation (a Sanofi company), Glatopa from Sandoz International GmbH (a Novartis AG company), Zinbryta from Biogen and AbbieVie, and Rituxan from F. Hoffman-La Roche AG.

Several biotechnology and pharmaceutical companies, as well as academic laboratories, are involved in research and/or product development for various neurological diseases, including MS. Other companies also have products in clinical development, including products approved for other indications in MS, to address improvement of walking ability in people with MS. Furthermore, several companies are engaged in developing products that include novel immune system approaches and cell therapy approaches to remyelination for the treatment of people with MS. These programs are in early stages of development and may compete in the future with Ampyra or some of our product candidates. In addition, in certain circumstances, pharmacists are not prohibited from formulating certain drug compounds to fill prescriptions on an individual patient basis, which is referred to as compounding. We are aware that at present compounded dalfampridine is used by some people with MS and it is possible that some people will want to continue to use compounded formulations even though Ampyra and generic versions of Ampyra are commercially available.

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

420 Saw Mill River Road, Ardsley, New York		10502
(Address of principal executive offices)		(Zip Code)

	Title of each class		Trading Symbol		Name of each exchange on which registered
	Common Stock $0.001 par value per share		ACOR		Nasdaq Global Select Market

Large accelerated filer	☐	Accelerated filer	☒☐
Non-accelerated filer	☐☒	Smaller reporting company	☐☒
Emerging growth company	☐

Class		Outstanding at ~~October 30, 2020~~November 5, 2021
Common Stock, $0.001 par value per share		~~47,962,400~~11,202,242 shares

		Page
PART I—FINANCIAL INFORMATION
Item 1.	Financial Statements	1
	Consolidated Balance Sheets as of September 30, ~~2020~~2021 (unaudited) and December 31, ~~2019~~2020	1
	Consolidated Statements of Operations (unaudited) for the Three and Nine-month Periods Ended September 30, ~~2020~~2021 and ~~2019~~2020	2
	Consolidated Statements of Comprehensive Income (Loss) (unaudited) for the Three and Nine-month Periods Ended September 30, ~~2020~~2021 and ~~2019~~2020	3
	Consolidated Statements of Changes in Stockholders’ Equity (unaudited) for the Three and Nine-month Periods Ended September 30, ~~2020~~2021 and ~~2019~~2020	4
	Consolidated Statements of Cash Flows (unaudited) for the Nine-month Periods Ended September 30, ~~2020~~2021 and ~~2019~~2020	6
	Notes to Consolidated Financial Statements (unaudited)	7
Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	2425
Item 3.	Quantitative and Qualitative Disclosures About Market Risk	4140
Item 4.	Controls and Procedures	41
PART II—OTHER INFORMATION
Item 1.	Legal Proceedings	42
Item 1A.	Risk Factors	42
Item 2.	Unregistered Sales of Equity Securities and Use of Proceeds	43
Item 5	Other Information	43
Item 6.	Exhibits	4745
Signatures		4846

	For the three-month period ended September 30,				For the nine-month period ended September 30,				For the three-month period ended September 30,				For the nine-month period ended September 30,
(In thousands)	2020		2019		2020		2019		2021		2020		2021		2020
Research and development expense	$	555	$	719	$	1,418	$	2,203	$	225	$	555	$	599	$	1,418
Selling, general and administrative expense		1,832		2,424		4,834		8,785		627		1,832		1,898		4,834
Cost of Sales		93		149		260		505		2		93		18		260
Total	$	2,480	$	3,292	$	6,512	$	11,493	$	854	$	2,480	$	2,515	$	6,512

(In thousands)
Restricted Stock and Performance Stock Units	Number of Shares
Nonvested at January 1, ~~2020~~2021		~~425~~31
Granted		0261
Vested		(497	)
Forfeited		(6053	)
Nonvested at September 30, ~~2020~~2021		~~361~~142

(In thousands)	September 30, 2020			June 30, 2020			March 31, 2020			December 31, 2019		Three-month period ended September 30, 2021			Three-month period ended September 30, 2020			Nine-month period ended September 30, 2021			Nine-month period ended September 30, 2020
Derivative Liability-Conversion Option
Balance, beginning of period	$	23,953		$	32,881		$	59,409		$	—	$	613		$	23,953		$	1,193		$	59,409
Fair value recognized upon issuance of Convertible Senior Notes		—			—			—			59,409
Fair value adjustment		(4,864	)		(8,928	)		(26,528	)		—		(288	)		(4,864	)		(868	)		(40,320	)
Fair value re-classification to shareholder's equity		(18,257	)		—			—			—		—			(18,257	)		—			(18,257	)
Balance, end of period	$	832		$	23,953		$	32,881		$	59,409	$	325		$	832		$	325		$	832

			Gross		Gross			Estimated
	Amortized		Unrealized		Unrealized			Fair
(In thousands)	Cost		Gains		Losses			Value
September 30, 2020
Corporate Bonds		5,341		6		-			5,347
Total Short-term investments	$	5,341	$	6	$	-		$	5,347
December 31, 2019
Commercial Paper	$	26,550	$	19	$	—		$	26,569
Corporate Bonds		37,177		20		(12	)		37,185
Total Short-term investments	$	63,727	$	39	$	(12	)	$	63,754

(In thousands)	Net Unrealized Gains (Losses) on Marketable Securities
Balance at December 31, 2019	$	27
Other comprehensive income before reclassifications:
Amounts reclassified from accumulated other comprehensive income		—
Net current period other comprehensive loss		(21	)
Balance at September 30, 2020	$	6

(In thousands)	Nine-month period ended September 30, 2020			Twelve-month period ended December 31, 2019			September 30, 2021			December 31, 2020
Liability related to sale of future royalties - beginning balance	$	24,401		$	30,716		$	15,257		$	24,401
Deferred transaction costs recognized		318			639
Deferred transaction costs amortized								193			401
Non-cash royalty revenue payable to HCRP		(8,496	)		(10,271	)		(8,889	)		(11,486	)
Non-cash interest expense recognized		1,548			3,317			891			1,941
Liability related to sale of future royalties - ending balance	$	17,771		$	24,401		$	7,452		$	15,257

(In thousands)	Balance Sheet Classification	September 30, 2020		September 30, 2019		Balance Sheet Classification	September 30, 2021		December 31, 2020
Right-of-use assets	Right of use assets	$	19,805	$	24,675	Right of use assets	$	7,861	$	18,481
Current lease liabilities	Current portion of lease liabilities		7,893		7,696	Current portion of lease liabilities		9,316		7,944
Non-current lease liabilities	Non-current portion of lease liabilities		18,747		24,393	Non-current portion of lease liabilities		4,287		17,200

(In thousands)
2020 (excluding the nine months ended September 30, 2020)	$	1,951
2021		7,944
2021 (excluding the nine months ended September 30, 2021)				$	1,553
2022		10,024			8,354
2023		3,097			1,216
2024		3,184			1,252
2025					1,290
Later years		4,594			1,327
Total lease payments		30,794			14,992
Less: Imputed interest		(4,155	)		(1,389	)
Present value of lease liabilities	$	26,639		$	13,603

(In thousands)	Restructuring Costs
Restructuring Liability as of December 31, 2020	$	—
Q1 Restructuring Costs		2,124
Q1 Restructuring Payments		(1,891	)
Restructuring Liability as of March 31, 2021	$	233
Q2 Restructuring Costs		27
Q2 Restructuring Payments		(128	)
Restructuring Liability as of June 30, 2021	$	132
Q3 Restructuring Costs		2,432
Q3 Restructuring Payments		(882	)
Restructuring Liability as of September 30, 2021	$	1,682

(In thousands)	September 30, 2020
Liability component:
Principal	$	69,000
Less: debt discount and debt issuance costs, net		(1,581	)
Net carrying amount	$	67,419
Equity component	$	22,791


Period	Total Number of Shares Purchased (1)	Average Price Paid per Share	Total Number of Shares Purchased as Part of Publicly Announced Plans or Programs	Maximum Number (or Approximate Dollar Value) of Shares that May Yet Be Purchased Under the Plans or Programs
September 1-30, 2021	14,973	$4.38	-	-
August 1-31, 2021	-	-	-	-
July 1-31, 2021	-	-	-	-
Total	14,973	$4.38	-	-

Exhibit No.		Description
~~3.1~~10.1*		~~Amended~~Employment Agreement dated September 1, 2020, by and ~~Restated Certificate of Incorporation of~~between the ~~Registrant.~~Company and Kerry Clem. Incorporated herein by reference to Exhibit ~~3.1 to the Registrant’s Registration Statement on Form S-1, No. 333-138842, filed on November 20, 2006.~~
~~3.2~~		~~Certificate of Amendment of Amended and Restated Certificate of Incorporation dated August 31, 2020. Incorporated by reference to Exhibit 3.1~~10.1 to the Registrant’s Current Report on ~~Form~~ 8-K filed ~~August 31, 2020.~~on September 9, 2021.
31.1		Certification by the Chief Executive Officer pursuant to Rule 13a-14(a) under the Securities Exchange Act of 1934.
31.2		Certification by the Principal Financial Officer pursuant to Rule 13a-14(a) under the Securities Exchange Act of 1934.
32.1		Certification by the Chief Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
32.2		Certification by the Principal Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
101.INS		Inline XBRL Instance Document.
101.SCH		Inline XBRL Taxonomy Extension Schema Document.
101.CAL		Inline XBRL Taxonomy Extension Calculation Linkbase Document.
101.DEF		Inline XBRL Taxonomy Extension Definition Linkbase Document.
101.LAB		Inline XBRL Taxonomy Extension Label Linkbase Document.
101.PRE		Inline XBRL Taxonomy Extension Presentation Linkbase Document.
104		Cover Page Interactive Data File, formatted in Inline XBRL (included in Exhibit 101).

	Acorda Therapeutics, Inc.

	By:	/s/ Ron Cohen
Date: November ~~6, 2020~~12, 2021		Ron Cohen, M.D. President, Chief Executive Officer and Director

	By:	/s/ ~~David Lawrence~~Michael A. Gesser
Date: November ~~6, 2020~~12, 2021		~~David Lawrence~~Michael A. Gesser Chief ~~Business Operations~~Financial Officer (Principal Financial and ~~Principal~~ Accounting ~~Officer~~Officer)