
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

			FORM 10-Q

(Mark one)

☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended ~~September~~June 30, ~~2021~~2022

☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from to

Commission File Number: 001-39452



INHIBRX, INC.

(Exact name of registrant as specified in its charter)

Delaware		82-4257312
(State or other jurisdiction of incorporation or organization)		(I.R.S. Employer Identification Number)

11025 N. Torrey Pines Road, Suite 200
La Jolla, California		92037
(Address of principal executive offices)		(Zip Code)

	(858) 795-4220
(Registrant’s telephone number, including area code)

Securities registered pursuant to Section 12(b) of the Act

Title of each class

Trading symbol(s)

Name of each exchange on which registered

Common Stock, par value $0.0001

INBX

The Nasdaq Global Market

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large Accelerated Filer

☐☒

Accelerated filer

☐

Non-accelerated filer

☒☐

Smaller reporting company

☒

Emerging growth company

☒☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☒☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒

As of ~~October 31, 2021,~~July 29, 2022, the registrant had ~~37,954,989~~39,057,686 shares of common stock outstanding.

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SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

This Quarterly Report on Form 10-Q, or this Quarterly Report, of Inhibrx, Inc., or Inhibrx, or the Company, (also referred to as “we,” “us,” and “our”) contains forward-looking statements that involve risks and uncertainties. Except as otherwise indicated by the context, references in this Quarterly Report to “we,” “us” and “our” are to the consolidated business of the Company. All statements other than statements of historical facts contained in this Quarterly Report are forward-looking statements. In some cases, you can identify forward-looking statements by words such as “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “possible,” “potential,” “predict,” “project,” “design,” “seek,” “should,” “target,” “will,” “would,” or the negative of these words or other comparable terminology. These forward-looking statements include, but are not limited to, statements about:

•the initiation, timing, progress and results of our research and development programs as well as our preclinical studies and clinical trials;

•our ability to advance therapeutic candidates into, and successfully complete, clinical trials;

•our interpretation of initial, interim or preliminary data from our clinical trials, including interpretations regarding disease control and disease response;

•the timing or likelihood of regulatory filings and approvals;

•the commercialization of our therapeutic candidates, if approved;

•the pricing, coverage and reimbursement of our therapeutic candidates, if approved;

•our ability to utilize our technology platform to generate and advance additional therapeutic candidates;

•the implementation of our business model and strategic plans for our business and therapeutic candidates;

•our ability to successfully manufacture our therapeutic candidates for clinical trials and commercial use, if approved;

•our ability to contract with third-party suppliers and manufacturers and their ability to perform adequately;

•the scope of protection we are able to establish and maintain for intellectual property rights covering our therapeutic candidates;

•our ability to enter into strategic partnerships and the potential benefits of such partnerships;

•our estimates regarding expenses, capital requirements and needs for additional financing;

•our ability to raise funds needed to satisfy our capital requirements, which may depend on financial, economic and market conditions and other factors, over which we may have no or limited control;

•our financial performance;

•our expectations regarding the impact of the COVID-19 pandemic on our business;

•our and our third party ~~partners~~partners’ and service providers’ ability to continue operations and advance our therapeutic candidates through clinical trials and the ability of our third party manufacturers to provide the required raw materials, antibodies and other biologics for our preclinical research and clinical trials in light of the COVID-19 pandemic, current market conditions and geopolitical events such as the ongoing ~~political unrest~~conflict in ~~Hong Kong;~~Ukraine;

•our ability to retain the continued service of our key professionals and to identify, hire and retain additional qualified professionals; and

•developments relating to our competitors and our industry.

These forward-looking statements are subject to a number of risks, uncertainties and assumptions, including those described in the section titled “Risk Factors” elsewhere in this Quarterly Report. Moreover, we operate in a very competitive and rapidly changing environment, and new risks emerge from time to time. It is not possible for our management to predict all risks, nor can we assess the impact of all factors on our business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements we may make. In light of these risks, uncertainties and assumptions, the forward-looking events and circumstances discussed in this Quarterly Report may not occur and actual results could differ materially and adversely from those anticipated or implied in the forward-looking statements. In addition, statements that “we believe” and similar statements reflect our beliefs and opinions on the relevant subject. These statements are based upon information available to us as of the date of this Quarterly Report, and while we believe such information forms a reasonable basis for such statements, such information may be limited or incomplete, and our statements

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should not be read to indicate that we have conducted an exhaustive inquiry into, or review of, all potentially available relevant information. These statements are inherently uncertain and investors are cautioned not to unduly rely upon these statements.

~~Table of Contents~~

You should not rely upon forward-looking statements as predictions of future events. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee that the future results, levels of activity, performance or events and circumstances reflected in the forward-looking statements will be achieved or occur. We undertake no obligation to update publicly any forward-looking statements for any reason after the date of this Quarterly Report to conform these statements to new information, actual results or to changes in our expectations, except as required by law.

You should read this Quarterly Report and the documents that we file with the Securities and Exchange Commission, or the SEC, with the understanding that our actual future results, levels of activity, performance, and events and circumstances may be materially different from what we expect.

This Quarterly Report includes trademarks, tradenames and service marks that are the property of other organizations. Solely for convenience, trademarks and tradenames referred to in this Quarterly Report appear without the ® and ™ symbols, but those references are not intended to indicate, in any way, that we will not assert, to the fullest extent under applicable law, our rights, or that the applicable owner will not assert its rights, to these trademarks and tradenames.

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TABLE OF CONTENTS


		~~PAGE~~Page
	Part I. Financial Information
Item 1.	Condensed Consolidated Balance Sheets as of ~~September~~June 30 ~~30, 2021~~, 2022 (unaudited) and December 31, ~~2020~~2021	4
	Condensed Consolidated Statements of Operations for the three and ~~nine~~six months ended ~~months ended~~ June 30 ~~September~~, 2022 and June 30 , 2021 ~~and 2020~~ (unaudited)	5
	Condensed Consolidated Statements of ~~Convertible Preferred Stock and~~ Stockholders’ Equity (Deficit) for the three and six ~~nine~~months ended ~~September~~June 30 , 2022 and June 30 , 2021 ~~and 2020~~ (unaudited)	6
	Condensed Consolidated Statements of Cash Flows for the ~~nine~~six months ended ~~September~~June 30 , 2022 and June 30, ~~30,~~ 2021 ~~and 2020~~ (unaudited)	87
	Notes to the Condensed Consolidated Financial Statements (unaudited)	108
Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	2722
Item 3.	Quantitative and Qualitative Disclosures about Market Risk	4137
Item 4.	Controls and Procedures	4238

	Part II. Other Information	4339
Item 1.	Legal Proceedings	4339
Item 1A.	Risk Factors	4339
Item 2.	Unregistered Sales of Securities and Use of Proceeds	4439
Item 3.	Defaults Upon Senior Securities	4540
Item 4.	Mine Safety Disclosures	4641
Item 5.	Other Information	4742
Item 6.	Exhibits	4843

	Signatures	4944

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Part I — Financial Information

Item 1. Financial Statements.

Inhibrx, Inc.
Condensed Consolidated Balance Sheets
(In thousands, except share data and par value)
(Unaudited)


		SEPTEMBER 30,		DECEMBER 31,			JUNE 30,		DECEMBER 31,
		2021		2020			2022		2021
		(unaudited)
Assets	Assets					Assets
Current assets:	Current assets:					Current assets:
Cash and cash equivalents	Cash and cash equivalents	$	112,704	$	128,664	Cash and cash equivalents	$	176,385	$	131,301
Accounts receivable	Accounts receivable	120		82		Accounts receivable	243		373
Receivables from related parties	Receivables from related parties	383		533		Receivables from related parties	41		505
Prepaid expenses and other current assets	Prepaid expenses and other current assets	5,825		2,893		Prepaid expenses and other current assets	4,954		6,933
Total current assets	Total current assets	119,032		132,172		Total current assets	181,623		139,112
Property and equipment, net	Property and equipment, net	3,178		3,492		Property and equipment, net	2,878		3,153
Right-of-use asset	Right-of-use asset	6,723		7,831		Right-of-use asset	5,545		6,338

Other non-current assets	Other non-current assets	245		245		Other non-current assets	3,164		1,847
Total assets	Total assets	$	129,178	$	143,740	Total assets	$	193,210	$	150,450
Liabilities and stockholders’ equity
Liabilities and stockholders’ equity (deficit)						Liabilities and stockholders’ equity (deficit)
Current liabilities:	Current liabilities:					Current liabilities:
Accounts payable	Accounts payable	$	12,425	$	13,458	Accounts payable	$	9,247	$	9,125
Accrued expenses	Accrued expenses	8,326		13,357		Accrued expenses	12,472		9,621
Current portion of deferred revenue	Current portion of deferred revenue	2,769		3,081		Current portion of deferred revenue	717		2,034

Current portion of lease liability	Current portion of lease liability	1,630		1,503		Current portion of lease liability	1,765		1,674

Total current liabilities	Total current liabilities	25,150		31,399		Total current liabilities	24,201		22,454

Non-current portion of deferred revenue		110		737
Long-term debt, net of current portion and including final payment fee	Long-term debt, net of current portion and including final payment fee	70,069		29,244		Long-term debt, net of current portion and including final payment fee	169,800		70,470

Non-current portion of lease liability	Non-current portion of lease liability	5,469		6,707		Non-current portion of lease liability	4,131		5,033
Non-current portion of deferred revenue						Non-current portion of deferred revenue	—		110

Other non-current liabilities		180		180

Total liabilities	Total liabilities	100,978		68,267		Total liabilities	198,132		98,067
Commitments and contingencies (Note 9)		0		0
Commitments and contingencies (Note 8)						Commitments and contingencies (Note 8)	0		0

Stockholders’ equity
Preferred stock, $0.0001 par value; 15,000,000 shares authorized as of September 30, 2021 and December 31, 2020; no shares issued or outstanding as of September 30, 2021 and December 31, 2020.		—		—
Common stock, $0.0001 par value; 120,000,000 shares authorized as of September 30, 2021 and December 31, 2020; 37,933,046 and 37,712,390 issued and outstanding as of September 30, 2021 and December 31, 2020, respectively.		4		4
Stockholders’ equity (deficit)						Stockholders’ equity (deficit)
Preferred stock, $0.0001 par value; 15,000,000 shares authorized as of June 30, 2022 and December 31, 2021; no shares issued or outstanding as of June 30, 2022 and December 31, 2021.						Preferred stock, $0.0001 par value; 15,000,000 shares authorized as of June 30, 2022 and December 31, 2021; no shares issued or outstanding as of June 30, 2022 and December 31, 2021.	—		—
Common stock, $0.0001 par value; 120,000,000 shares authorized as of June 30, 2022 and December 31, 2021; 39,041,834 and 38,991,307 issued and outstanding as of June 30, 2022 and December 31, 2021, respectively.						Common stock, $0.0001 par value; 120,000,000 shares authorized as of June 30, 2022 and December 31, 2021; 39,041,834 and 38,991,307 issued and outstanding as of June 30, 2022 and December 31, 2021, respectively.	4		4
Additional paid-in-capital	Additional paid-in-capital	234,154		220,848		Additional paid-in-capital	291,207		279,526
Accumulated deficit	Accumulated deficit	(205,958)		(145,379)		Accumulated deficit	(296,133)		(227,147)
Total stockholders’ equity		28,200		75,473
Total liabilities and stockholders’ equity		$	129,178	$	143,740
Total stockholders’ equity (deficit)						Total stockholders’ equity (deficit)	(4,922)		52,383
Total liabilities and stockholders’ equity (deficit)						Total liabilities and stockholders’ equity (deficit)	$	193,210	$	150,450

The accompanying notes are an integral part of these condensed consolidated financial statements.

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Inhibrx, Inc.
Condensed Consolidated Statements of Operations
(In thousands, except per share data)
(Unaudited)


		THREE MONTHS ENDED SEPTEMBER 30,				NINE MONTHS ENDED SEPTEMBER 30,					THREE MONTHS ENDED JUNE 30,				SIX MONTHS ENDED JUNE 30,
		2021		2020		2021		2020			2022		2021		2022		2021

Revenue:	Revenue:									Revenue:
License fee revenue	License fee revenue	$	2,508	$	5,826	$	4,289	$	10,032	License fee revenue	$	711	$	918	$	1,626	$	1,781
Grant revenue	Grant revenue	24		75		86		80		Grant revenue	—		36		14		62
Total revenue	Total revenue	2,532		5,901		4,375		10,112		Total revenue	711		954		1,640		1,843
Operating expenses:	Operating expenses:									Operating expenses:
Research and development	Research and development	18,485		19,837		52,825		55,827		Research and development	29,906		17,902		54,801		34,340
General and administrative	General and administrative	2,848		1,622		8,710		4,621		General and administrative	5,402		2,853		10,453		5,862

Total operating expenses	Total operating expenses	21,333		21,459		61,535		60,448		Total operating expenses	35,308		20,755		65,254		40,202
Loss from operations	Loss from operations	(18,801)		(15,558)		(57,160)		(50,336)		Loss from operations	(34,597)		(19,801)		(63,614)		(38,359)
Other income (expense):	Other income (expense):									Other income (expense):
Interest expense, net	Interest expense, net	(1,778)		(4,428)		(3,437)		(10,284)		Interest expense, net	(3,148)		(914)		(5,422)		(1,659)
Other income (expense), net		(1)		—		20		5
Change in fair value of warrant liabilities		—		(24)		—		(24)
Change in fair value of derivative liabilities		—		—		—		2,651
Other income, net										Other income, net	17		5		54		21

Total other expense	Total other expense	(1,779)		(4,452)		(3,417)		(7,652)		Total other expense	(3,131)		(909)		(5,368)		(1,638)
Loss before income tax expense	Loss before income tax expense	(20,580)		(20,010)		(60,577)		(57,988)		Loss before income tax expense	(37,728)		(20,710)		(68,982)		(39,997)
Provision for income taxes	Provision for income taxes	—		—		2		—		Provision for income taxes	4		—		4		2
Loss on equity method investment		—		487		—		487

Net loss	Net loss	(20,580)		(20,497)		(60,579)		(58,475)		Net loss	(37,732)		(20,710)		(68,986)		(39,999)
Net loss per share, basic and diluted	Net loss per share, basic and diluted	$	(0.54)	$	(0.77)	$	(1.60)	$	(2.78)	Net loss per share, basic and diluted	$	(0.97)	$	(0.55)	$	(1.77)	$	(1.06)
Weighted-average shares of common stock outstanding, basic and diluted	Weighted-average shares of common stock outstanding, basic and diluted	37,893		26,750		37,818		21,019		Weighted-average shares of common stock outstanding, basic and diluted	39,040		37,824		39,029		37,780

The accompanying notes are an integral part of these condensed consolidated financial statements.

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Inhibrx, Inc.
Condensed Consolidated Statements of ~~Convertible Preferred Stock and~~ Stockholders’ Equity (Deficit)
(In thousands)
(Unaudited)


		Convertible Preferred Stock (Shares)	Convertible Preferred Stock (Amount)		Common Stock (Shares)	Common Stock (Amount)		Additional Paid-In Capital		Accumulated Deficit		Total Stockholders’ Equity (Deficit)			Common Stock (Shares)	Common Stock (Amount)		Additional Paid-In Capital		Accumulated Deficit		Total Stockholders’ Equity (Deficit)
Balance as of December 31, 2020		—	$	—	37,712	$	4	$	220,848	$	(145,379)	$	75,473
Balance as of December 31, 2021														Balance as of December 31, 2021	38,991	$	4	$	279,526	$	(227,147)	$	52,383
Stock-based compensation expense														Stock-based compensation expense	—	—		5,108		—		5,108
Issuance of shares upon exercise of stock options														Issuance of shares upon exercise of stock options	35	—		401		—		401
Issuance of warrants														Issuance of warrants	—	—		712		—		712
Net loss														Net loss	—	—		—		(31,254)		(31,254)
Balance as of March 31, 2022														Balance as of March 31, 2022	39,026	$	4	$	285,747	$	(258,401)	$	27,350
Stock-based compensation expense	Stock-based compensation expense	—	—		—	—		3,421		—		3,421		Stock-based compensation expense	—	—		5,296		—		5,296
Issuance of shares upon exercise of stock options	Issuance of shares upon exercise of stock options	—	—		93	—		988		—		988		Issuance of shares upon exercise of stock options	15	—		164		—		164
Net loss	Net loss	—	—		—	—		—		(19,289)		(19,289)		Net loss	—	—		—		(37,732)		(37,732)
Balance as of March 31, 2021		—	$	—	37,805	$	4	$	225,257	$	(164,668)	$	60,593
Stock-based compensation expense		—	—		—	—		3,951		—		3,951
Issuance of shares upon exercise of stock options		—	—		44	—		485		—		485
Net loss		—	—		—	—		—		(20,710)		(20,710)
Balance as of June 30, 2021		—	$	—	37,849	$	4	$	229,693	$	(185,378)	$	44,319
Stock-based compensation expense		—	—		—	—		3,493		—		3,493
Issuance of shares upon exercise of stock options		—	—		84	—		968		—		968
Net loss		—	—		—	—		—		(20,580)		(20,580)
Balance as of September 30, 2021		—	$	—	37,933	$	4	$	234,154	$	(205,958)	$	28,200
Balance as of June 30, 2022														Balance as of June 30, 2022	39,041	$	4	$	291,207	$	(296,133)	$	(4,922)


	Common Stock (Shares)	Common Stock (Amount)		Additional Paid-In Capital		Accumulated Deficit		Total Stockholders’ Equity
Balance as of December 31, 2020	37,712	$	4	$	220,848	$	(145,379)	$	75,473
Stock-based compensation expense	—	—		3,421		—		3,421
Issuance of shares upon exercise of stock options	93	—		988		—		988
Net loss	—	—		—		(19,289)		(19,289)
Balance as of March 31, 2021	37,805	$	4	$	225,257	$	(164,668)	$	60,593
Stock-based compensation expense	—	—		3,951		—		3,951
Issuance of shares upon exercise of stock options	44	—		485		—		485
Net loss	—	—		—		(20,710)		(20,710)
Balance as of June 30, 2021	37,849	$	4	$	229,693	$	(185,378)	$	44,319

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Convertible Preferred Stock
(Shares) Convertible Preferred Stock
(Amount) Common Stock
(Shares) Common Stock (Amount) Additional Paid-In Capital Accumulated Deficit Total Stockholders’ Equity
(Deficit)
Balance as of December 31, 2019 12,534 $ 59,507 18,154 $ 2 $ (24,316) $ (69,255) $ (93,569)
Stock-based compensation expense — — — — 1,088 — 1,088
Net loss — — — — — (20,093) (20,093)
Balance as of March 31, 2020 12,534 $ 59,507 18,154 $ 2 $ (23,228) $ (89,348) $ (112,574)
Stock-based compensation expense — — — — 1,259 — 1,259
2020 Notes - beneficial conversion feature — — — — 2,656 — 2,656
Net loss — — — — — (17,885) (17,885)
Balance as of June 30, 2020 12,534 $ 59,507 18,154 $ 2 $ (19,313) $ (107,233) $ (126,544)
Stock-based compensation expense — — — — 1,303 — 1,303
Issuance of shares upon exercise of stock options — — — — 4 — 4
Issuance of shares in IPO, net of issuance costs — — 8,050 1 125,862 — 125,863
Issuance of shares in conversion of preferred shares (12,534) (59,507) 7,211 1 59,506 — 59,507
Issuance of shares in conversion of the 2019 Note the 2020 Notes — — 4,295 — 59,393 — 59,393
Reversal of unamortized BCF on the 2019 Note — — — — (5,332) — (5,332)
Reversal of unamortized BCF on the 2020 Notes — — — — (2,107) — (2,107)
Reclassification of warrant liabilities into equity — — — — 139 — 139
Net loss — — — — — (20,497) (20,497)
Balance as of September 30, 2020 — $ — 37,710 $ 4 $ 219,455 $ (127,730) $ 91,729

The accompanying notes are an integral part of these condensed consolidated financial statements.

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Inhibrx, Inc.
Condensed Consolidated Statements of Cash Flows
(In thousands)
(Unaudited)

NINE MONTHS ENDED
SEPTEMBER 30,
2021 2020
Cash flows from operating activities
Net loss $ (60,579) $ (58,475)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization 888 754
Accretion of debt discount and non-cash interest expense 833 10,046
Stock-based compensation expense 10,865 3,650
Non-cash lease expense 1,108 1,020
Change in fair value of derivative liabilities — (2,651)
Change in fair value of warrant liabilities — 24
Loss from equity method investment — 487
Gain on disposal of fixed assets (9) —
Changes in operating assets and liabilities:
Accounts receivable (38) (482)
Receivables from related parties 150 (44)
Prepaid expenses and other current assets (2,586) 366
Accounts payable (1,232) 11,605
Accrued expenses and other current liabilities (5,053) 6,196
Operating lease liability (1,111) (995)
Deferred revenue, current portion (312) (3,250)
Deferred revenue, non-current portion (627) (830)
Net cash used in operating activities (57,703) (32,579)
Cash flows from investing activities
Purchase of fixed assets (597) (752)
Proceeds from the sale of property and equipment 55 —
Net cash used in investing activities (542) (752)
Cash flows from financing activities
Proceeds from initial public offering, gross — 136,850
Costs associated with initial public offering — (10,558)
Deferred offering costs paid (148) —
Proceeds from the issuance of convertible notes — 15,000
Proceeds from the issuance of debt 39,992 9,958
Payment of fees associated with debt — (86)
Proceeds from the Paycheck Protection Program loan — 1,875
Repayment of principal on debt — (2,183)
Final payment on debt — (1,400)
Proceeds from the exercise of stock options 2,441 4
Net cash provided by financing activities 42,285 149,460
Net increase (decrease) in cash and cash equivalents (15,960) 116,129
Cash and cash equivalents at beginning of period 128,664 11,540
Cash and cash equivalents at end of period $ 112,704 $ 127,669

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Supplemental disclosure of cash flow information
Cash paid for interest $ 2,001 $ 172
Cash paid for income taxes $ 2 $ —
Supplemental schedule of non-cash investing and financing activities
Deferred offering costs included in accounts payable and accrued expenses $ 198 $ 430
Payable for purchase of fixed assets $ 23 $ 46
Conversion of preferred stock to common stock $ — $ 59,507
Conversion of the 2019 Note and the 2020 Notes to common stock $ — $ 53,394
Debt discount arising from convertible note beneficial conversion features and reversal of beneficial conversion features $ — $ 4,783
Operating lease liabilities arising from obtaining right-of-use assets $ — $ 1,752
Derivative liabilities arising from the issuance of the 2019 Note and the 2020 Notes $ — $ 735
Non-cash equity method investment $ — $ 487
Reclassification of warrant liabilities to equity $ — $ 139
Warrant liabilities issued to lender in conjunction with 2020 Loan Agreement $ — $ 115
Initial public offering costs included in accounts payable and accrued expenses $ — $ 5


	SIX MONTHS ENDED JUNE 30,
	2022		2021
Cash flows from operating activities
Net loss	$	(68,986)	$	(39,999)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	614		589
Accretion of debt discount and non-cash interest expense	1,171		434
Stock-based compensation expense	10,404		7,372
Non-cash lease expense	793		731
(Gain) loss on disposal of fixed assets	6		(9)
Changes in operating assets and liabilities:
Accounts receivable	130		(135)
Receivables from related parties	464		222
Prepaid expenses and other current assets	2,029		(2,130)

Other non-current assets	(1,317)		—
Accounts payable	216		(3,572)
Accrued expenses and other current liabilities	2,851		(6,373)
Operating lease liability	(811)		(727)
Deferred revenue, current portion	(1,317)		156
Deferred revenue, non-current portion	(110)		(587)

Net cash used in operating activities	(53,863)		(44,028)
Cash flows from investing activities
Purchase of fixed assets	(439)		(428)
Proceeds from the sale of property and equipment	—		55
Net cash used in investing activities	(439)		(373)
Cash flows from financing activities




Proceeds from the issuance of debt	98,871		39,992
Payment of fees associated with debt	(50)		—



Proceeds from the exercise of stock options	565		1,473

Net cash provided by financing activities	99,386		41,465
Net increase (decrease) in cash and cash equivalents	45,084		(2,936)
Cash and cash equivalents at beginning of period	131,301		128,664
Cash and cash equivalents at end of period	$	176,385	$	125,728
Supplemental disclosure of cash flow information
Cash paid for interest	$	3,975	$	1,322
Cash paid for income taxes	$	4	$	2
Supplemental schedule of non-cash investing and financing activities
Fair value of warrants issued to lender in conjunction with February 2022 Amendment	$	712	$	—
Payable for purchase of fixed assets	$	—	$	33

The accompanying notes are an integral part of these condensed consolidated financial statements.

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Inhibrx, Inc.
Notes to Unaudited Condensed Consolidated Financial Statements

1. ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Organization

Inhibrx, Inc., or the Company, or Inhibrx, is a clinical-stage biotechnology company focused on developing a broad pipeline of novel biologic therapeutic candidates. The Company combines a deep understanding of target biology with innovative protein engineering, proprietary discovery technologies, and an integrative approach to research and development to design highly differentiated therapeutic candidates. The Company’s current pipeline is focused on oncology and orphan diseases.

~~Impact of COVID-19 Pandemic~~

In response to the global outbreak of COVID-19 and the World Health Organization’s classification of the outbreak as a pandemic, the Company continues to take the necessary precautions to ensure the safety of its employees and to minimize interruptions to its operations. The full impact of the COVID-19 outbreak continues to evolve as of the date of these financial statements. While the pandemic has not yet had a material effect on the Company’s financial results, it is uncertain as to the full magnitude of impact the pandemic will have on the Company’s financial condition, liquidity and future results of operations. Management is actively monitoring the risks to public health and the impact of overall global business activity on its financial condition, liquidity, operations, suppliers, industry, and workforce.

The U.S. federal government enacted the Coronavirus Aid, Relief, and Economic Security Act, or CARES Act, which, among a number varied provisions aimed to ease tax burdens on companies during the COVID pandemic, permitted employers to defer the payment of the employer share of social security taxes due for the period beginning March 27, 2020 and ending December 31, 2020. Of the amounts deferred, 50% is required to be paid by December 31, 2021 and the remaining 50% is required to be paid by December 31, 2022. The Company began deferring payment of the employer share of social security taxes in April 2020. As of September 30, 2021 and December 31, 2020, the Company had deferred payment of $0.4 million of such taxes, $0.2 million of which are classified as accrued expenses and $0.2 million of which are classified as other non-current liabilities in the Company’s condensed consolidated balance sheets.

~~The Company will continue to examine and evaluate any impacts the CARES Act and associated subsequent legislation may have on its business and taxes.~~

~~Reverse Stock Split~~

On August 11, 2020 the Company effected a one-for-1.7382 reverse stock split of the Company’s common stock, or the Reverse Stock Split. The par value and the authorized shares of the common stock were not adjusted as a result of the Reverse Stock Split. All issued and outstanding common stock and the conversion prices of the convertible preferred stock and convertible notes have been retroactively adjusted to reflect this Reverse Stock Split for all periods presented.

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America, or GAAP, and applicable rules and regulations of the Securities and Exchange Commission, or the SEC, related to an interim report on the Form 10-Q.

The unaudited interim condensed financial statements reflect all adjustments which, in the opinion of management, are necessary for a fair statement of the results for the periods presented. All such adjustments are of a normal and recurring nature. The operating results presented in these unaudited interim condensed financial statements are not necessarily indicative of the results that may be expected for any future periods.

Certain information and note disclosures normally included in annual financial statements prepared in accordance with GAAP have been condensed or omitted. Accordingly, the accompanying unaudited interim financial statements

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should be read in conjunction with the audited financial statements and the related notes thereto for the year ended December 31, ~~2020,~~2021, which are included in the Company’s Annual Report on Form 10-K filed with the SEC.

Liquidity

On August 21, 2020, the Company completed its initial public offering, or IPO, in which it sold 8,050,000 shares of common stock at an offering price of $17.00 per share. Net proceeds from the IPO were $125.9 million, net of underwriting discounts, commissions, and offering costs.

As of ~~September~~June 30, ~~2021,~~2022, the Company had an accumulated deficit of ~~$206.0~~$296.1 million and cash and cash equivalents of ~~$112.7~~$176.4 million. From its inception and through ~~September~~June 30, ~~2021,~~2022, the Company has devoted substantially all of its efforts to therapeutic drug discovery and development, conducting preclinical studies and clinical trials, enabling manufacturing activities in support of its therapeutic candidates, organizing and staffing the Company, establishing its intellectual property portfolio and raising capital to support and expand these activities.

The Company believes that its existing cash and cash equivalents will be sufficient to fund the Company’s operations for at least 12 months from the date these condensed consolidated financial statements are issued. The Company plans to finance its future cash needs through equity offerings, debt financings or other capital sources, including potential collaborations, licenses, strategic transactions, and other similar arrangements.

As discussed in Note 4, the Company entered into the Open Market Sale Agreement, or the Sales Agreement, with Jefferies LLC, or the Sales Agent, under which it may, from time to time, sell shares of its common stock having an aggregate offering price of up to $200.0 million through the Sales Agent, or the ATM Offering. During the year ended December 31, 2021, the Company sold 921,042 shares pursuant to the Sales Agreement for net proceeds of $40.2 million, after deducting commissions. During the six months ended June 30, 2022, the Company did not issue any shares under the Sales Agreement.

As discussed in Note 3, the Company received $40.0 million in gross proceeds upon entering into the February 2022 Amendment to the 2020 Loan Agreement, as amended (both as defined below). Pursuant to the Amended 2020 Loan Agreement (as defined below), 3 additional tranches became available upon the occurrence of contingent events, for additional gross proceeds of up to $90.0 million. In June 2022, 2 of these tranches were drawn for additional gross proceeds of $60.0 million.

If the Company does raise additional capital through public or private equity or convertible debt offerings, the ownership interests of its existing stockholders will be diluted, and the terms of those securities may include liquidation or other preferences that adversely affect its stockholders’ rights. If the Company raises capital through

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additional debt financings, it may be subject to covenants limiting or restricting its ability to take specific actions, such as incurring additional debt or making certain capital expenditures. To the extent that the Company raises additional capital through strategic licensing, collaboration or other similar agreement, it may have to relinquish valuable rights to its therapeutic candidates, future revenue streams or research programs at an earlier stage of development or on less favorable terms than it would otherwise choose, or to grant licenses on terms that may not be favorable to the Company. There can be no assurance as to the availability or terms upon which such financing and capital might be available in the future. If the Company is unable to secure adequate additional funding, it will need to reevaluate its operating plan and may be forced to make reductions in spending, extend payment terms with suppliers, liquidate assets where possible, delay, scale back or eliminate some or all of its development programs, or relinquish rights to its technology on less favorable terms than it would otherwise choose. These actions could materially impact its business, financial condition, results of operations and prospects.

The Company currently has an effective shelf registration statement on Form S-3ASR filed with the SEC, or the Shelf Registration. The Shelf Registration statement permits the offering, issuance and sale by the Company of up to an aggregate offering price of $400.0 million of common stock, preferred stock, debt securities and warrants in one or more offerings and in any combination, of which common stock in an aggregate offering price of up to $200.0 million may be issued and sold by the Company through the Sales Agent pursuant to an Open Market Sale Agreement, or the Sales Agreement. As of September 30, 2021, no shares have been sold pursuant to the Sales Agreement.

~~The~~ rules and regulations of the SEC or any other regulatory agencies may restrict the Company’s ability to conduct certain types of financing activities, or may affect the timing of and amounts it can raise by undertaking such activities.

Impact of COVID-19 Pandemic

In response to the global COVID-19 pandemic, the Company continues to take the necessary precautions to ensure the safety of its employees and to minimize interruptions to its operations. The full impact of the COVID-19 outbreak continues to evolve as of the date of these financial statements. While the pandemic has not yet had a material effect on the Company’s financial results, the degree to which COVID-19, including new variants of the virus, may impact the Company’s financial condition, liquidity and future results of operations is uncertain. Management is actively monitoring the risks to public health and the impact of overall global business activity on its financial condition, liquidity, operations, suppliers, industry, and workforce.

The U.S. federal government enacted the Coronavirus Aid, Relief, and Economic Security Act, or CARES Act, which, among a number of varied provisions aimed to ease tax burdens on companies during the COVID pandemic, permitted employers to defer the payment of the employer share of social security taxes due for the period beginning March 27, 2020 and ending December 31, 2020. Of the amounts deferred, 50% was required to be paid by December 31, 2021 and the remaining 50% is required to be paid by December 31, 2022. The Company began deferring payment of the employer share of social security taxes in April 2020 and deferred a total of $0.4 million of such taxes during the period. The Company paid $0.3 million of deferred taxes during December 2021. As of June 30, 2022, the Company has a remaining deferred payment of $0.1 million of such taxes, which are classified as accrued expenses in the Company’s condensed consolidated balance sheets.

Use of Estimates

The preparation of these unaudited condensed consolidated financial statements in conformity with GAAP requires the Company to make estimates and judgments that affect the reported amounts of assets, liabilities, revenue and expense and the disclosure of contingent assets and liabilities in the Company’s financial statements and accompanying notes. The Company’s most significant estimates relate to ~~evaluation of embedded derivative instruments and beneficial conversion features within its previously issued and outstanding convertible notes,~~ whether revenue recognition criteria have been met, accounting for development work and preclinical studies and clinical trials, determining the assumptions used in measuring stock-based compensation, ~~the incremental borrowing rate estimated in relation to the Company’s operating lease,~~ and valuation allowances for the Company’s deferred

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tax assets. The Company bases its estimates on historical experience, known trends and other market-specific or other relevant factors that it believes to be reasonable under the circumstances. Estimates are periodically reviewed in light of changes in circumstances, facts and experience. Changes in estimates are recorded in the period in which they become known. The Company’s actual results may differ from these estimates under different assumptions or conditions.

Concentrations of Credit Risk

The Company maintains deposits in federally insured financial institutions in excess of federally insured limits. The Company has not experienced any losses in such accounts and believes it is not exposed to significant risk on its cash balances due to the financial condition of the depository institutions in which those deposits are held.

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Fair Value Measurements

The Company determines the fair value measurements of applicable assets and liabilities based on a three-tier fair value hierarchy established by accounting guidance and prioritizes the inputs used in measuring fair value. These tiers include:

•Level 1 - Quoted prices in active markets for identical assets or liabilities.

•Level 2 - Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

•Level 3 - Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

In certain cases, the inputs used to measure fair value may fall into different levels of the fair value hierarchy. In such cases, the level in the fair value hierarchy within which the fair value measurement in its entirety falls has been determined based on the lowest level input that is significant to the fair value measurement in its entirety. The Company’s assessment of the significance of a particular input to the fair value measurement in its entirety requires judgment and considers factors specific to the asset or liability.

~~The 2019 Note and the 2020 Notes contained embedded derivative liabilities (see Note 4). The 2020 Loan Agreement contained warrant liabilities (see Note 3). Prior to the completion~~As of the IPO in August 2020, these were classified within Level 3 of the hierarchy, since they were valued by using inputs that were unobservable in the market. Upon the consummation of the IPO in August 2020 and as of SeptemberJune 30, ~~2021~~2022 and December 31, ~~2020,~~2021, the ~~derivative liabilities and warrant liabilities~~Company had no ~~longer existed.~~financial instruments measured at fair value on a recurring basis.

Deferred Offering Costs

~~Deferred offering~~The Company capitalizes costs that are directly associated with equity financings until such financings are consummated, at which time such costs are ~~legal,~~recorded against the gross proceeds of the offering. Legal, accounting, ~~printing,~~ and filing fees ~~that the Company has capitalized that are~~related directly ~~related~~ to the ~~Shelf Registration.~~Company’s Sales Agreement are capitalized as deferred offering costs. Deferred offering costs associated with the ~~Shelf Registration will be~~Sales Agreement are reclassified to additional paid-in capital ~~on a pro-rata basis~~ when the Company completes offerings under the Shelf ~~Registration, with any remaining deferred~~Registration. In November 2021, the Company completed an ATM Offering under the Sales Agreement and offset $1.7 million of offering costs against the proceeds.

Financial Instruments with Characteristics of Both Liabilities and Equity

The Company accounts for issued warrants either as a liability or equity in accordance with ASC 480-10, Accounting for Certain Financial Instruments with Characteristics of both Liabilities and Equity (“ASC 480-10”) or ASC 815-40, Accounting for Derivative Financial Instruments Indexed to, and Potentially Settled in, a Company’s Own Stock (“ASC 815-40”). Under ASC 480-10, warrants are considered a liability if they are mandatorily redeemable and they require settlement in cash, other assets, or a variable number of shares. If warrants do not meet liability classification under ASC 480-10, the Company considers the requirements of ASC 815-40 to determine whether the warrants should be ~~charged to~~classified as a liability or as equity. Under ASC 815-40, contracts that may require settlement for cash are liabilities, regardless of the ~~results~~probability of ~~operations~~the occurrence of the triggering event. Liability-classified warrants are measured at fair value on the issuance date and at the end of each reporting period. Any change in the ~~three-year life~~fair value of the ~~Shelf Registration.~~warrants after the issuance date is recorded in other expense, net in the condensed consolidated statements of operations as a gain or loss. If warrants do not require liability classification under ASC 815-40, in order to conclude warrants should be classified as equity, the Company assesses whether the warrants are indexed to its common stock and whether the warrants are classified as equity under ASC 815-40 or under another applicable GAAP standard. Equity-classified warrants are accounted for at fair value on the issuance date with no changes in fair value recognized after the issuance date. The Company’s outstanding warrants do not meet the requirements for liability classification under ASC-480-10 or ASC-815-40. Therefore, the warrants were treated as equity at the time of issuance.

Revenue Recognition

The Company has generated revenue from its license and collaboration agreements with partners, as well as from grants from government agencies and private not-for-profit organizations. Payments received from customers are included in deferred revenue, allocated between current and non-current on the condensed consolidated balance sheet until all revenue recognition criteria are met. In accordance with ASC Topic 606, Revenue from Contracts with

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Customers, or ASC Topic 606, the Company recognizes revenue when, or as, the promised goods or services are transferred to customers in an amount that reflects the consideration to which it expects to be entitled in exchange for those services. To determine revenue recognition for arrangements the Company concludes are within the scope of ASC Topic 606, the Company performs the following five steps: (1) identify the contract(s) with a customer; (2) identify the performance obligation(s) in the contract; (3) determine the transaction price; (4) allocate the transaction price to the performance obligation(s) in the contract; and (5) recognize revenue when (or as) the performance obligation(s) are satisfied. At contract inception, the Company assesses the goods or services promised

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within each contract, assesses whether each promised good or service is distinct and identifies those that are performance obligations. The Company recognizes as revenue the amount of the transaction price that is allocated to the respective performance obligation when, or as, the performance obligation is satisfied.

Collaborative Research, Development, and License Agreements

The Company enters into collaborative agreements with partners that typically include one or more of the following: (1) license fees; (2) nonrefundable up-front fees; (3) payments for reimbursement of research costs; (4) payments associated with achieving specific development, regulatory, or commercial milestones; and (5) royalties based on specified percentages of net product sales, if any. At the initiation of an agreement, the Company analyzes whether each unit of account results in a contract with a customer under ASC Topic 606 or in an arrangement with a collaborator subject to guidance under ASC Topic 808, Collaborative Arrangements ~~or ASC Topic 808.~~. The Company’s licensing arrangements are typically for functional intellectual property as it exists at a point in time, being the time that the license agreement is executed. The Company typically does not have an ongoing performance obligation to support or maintain the licensed intellectual property.

The Company considers a variety of factors in determining the appropriate estimates and assumptions under these arrangements, such as whether the elements are distinct performance obligations, whether there are observable stand-alone prices, and whether any licenses are functional or symbolic. The Company evaluates each performance obligation to determine if it can be satisfied and recognized as revenue at a point in time or over time. Typically, license fees, non-refundable upfront fees, and funding of research activities are considered fixed, while milestone payments are identified as variable consideration which must be evaluated to determine if it is constrained and, therefore, excluded from the transaction price. The Company estimates the amount of variable consideration using the most likely amount, as milestone payments typically only have two possible outcomes. The Company recognizes revenue for sales-based royalty promised in exchange for the license of intellectual property only when the subsequent sale occurs. In the case of an agreement which provides the partner with an option to license a therapeutic or therapeutic candidate in the future, the Company evaluates whether this option represents a material right at the inception of the agreement. If determined to be a material right, the Company will consider the option a separate performance obligation. The Company has historically concluded that the option to grant a license in the future ~~are~~is not a material rights as ~~they~~it is are contingent upon future events which may not occur. When an option is exercised, the Company will identify any separate performance obligations.

The Company may allocate transaction price using a number of methods including estimating standalone selling price of performance obligations and using the residual approach when the standalone selling price of the license is highly variable or uncertain, and observable standalone selling prices exist for the other goods or services promised in the contract.

Research and Development and Clinical Trial Accruals

Research and development costs are expensed as incurred and include the cost of compensation and related expenses, as well as expenses for third parties who conduct research and development on the Company’s behalf, pursuant to development and consulting agreements in place. The Company’s preclinical studies and clinical trials are performed internally, by third party contract research organizations, or CROs, and/or clinical investigators. The Company also engages with contract development and manufacturing organizations, or CDMOs, for clinical supplies and manufacturing scale-up activities related to its therapeutic candidates. Invoicing from these third parties may be monthly based upon services performed or based upon milestones achieved. The Company accrues these expenses based upon its assessment of the status of each clinical trial and the work completed, and upon information obtained from the CROs and CDMOs. The Company’s estimates are dependent upon the timeliness and accuracy of data provided by the CROs and CDMOs regarding the status and cost of the studies. Costs incurred related to the

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Company’s purchases of in-process research and development for early-stage products or products that are not commercially viable and ready for use, or have no alternative future use, are charged to expense in the period incurred. Costs incurred related to the licensing of products that have not yet received ~~regulatory~~marketing approval to be marketed, or that are not commercially viable and ready for use, or have no alternative future use, are charged to expense in the period incurred.

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Income Taxes

Income taxes are accounted for under the asset and liability method. Deferred income taxes are recorded for temporary differences between financial statement carrying amounts and the tax basis of assets and liabilities. Deferred tax assets and liabilities reflect the tax rates expected to be in effect for the years in which the differences are expected to reverse. A valuation allowance is provided if it is more likely than not that some or all of the deferred tax assets will not be realized.

Net Loss Per Share

Basic net loss per share is computed by dividing net loss by the weighted average number of common shares outstanding during the same period. Diluted net loss per share is computed by dividing net loss by the weighted average number of common and common equivalent shares outstanding during the same period. The Company excludes common stock equivalents from the calculation of diluted net loss per share when the effect is anti-dilutive.

For purposes of the diluted net loss per share calculation, ~~the convertible preferred stock, convertible notes,~~ warrants for purchase of common stock and stock options are considered to be potentially dilutive securities. Basic and diluted net loss attributable to common stockholders per share is presented in conformity with the two class method required for participating securities as the convertible preferred stock is considered a participating security for the nine months ended September 30, 2020. The Company’s participating securities do not have a contractual obligation to share in the Company’s losses. As such, the net loss was attributed entirely to common stockholders. Accordingly, for the ~~nine~~six months ended ~~September~~June 30, ~~2021~~2022 and ~~2020,~~June 30, 2021, there is no difference in the number of shares used to calculate basic and diluted shares outstanding.

Potentially dilutive securities not included in the calculation of diluted net loss per share, because to do so would be anti-dilutive, are as follows (in thousands):


		AS OF SEPTEMBER 30,		AS OF JUNE 30,
		2021	2020			2022	2021

Outstanding stock options	Outstanding stock options	3,983	2,355		Outstanding stock options	5,196	4,211

Warrants to purchase common stock	Warrants to purchase common stock	7	7		Warrants to purchase common stock	47	7
		3,990	2,362			5,243	4,218

Segment Information

The Company operates under 1 segment which develops biologic therapeutic candidates. Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision-maker in making decisions regarding resource allocation and assessing performance.

Recent Accounting Pronouncements

From time to time, new accounting pronouncements are issued by the FASB or other standard setting bodies. The Company believes that the impact of the recently issued accounting pronouncements that are not yet effective will not have a material impact on its condensed consolidated financial condition or results of operations upon adoption. The Company has irrevocably elected not to take advantage of the extended transition period afforded by the Jumpstart Our Business Startups Act of 2012, as amended, or the JOBS Act, for the implementation of new or revised accounting standards and, as a result, will comply with new or revised accounting standards on the relevant dates on which adoption of such standards is required for non-emerging growth companies.

Adoption of New Accounting Pronouncements

In ~~January 2020,~~May 2021, the FASB issued ASU ~~2020-01,~~2021-04, Earnings Per Share ~~Investments-Equity Securities,~~(Topic 260), Debt-Modifications and Extinguishments ~~or Topic 321,~~(Subtopic 470-50), Compensation-Stock Compensation ~~Investments-Equity Method~~(Topic 718), and ~~Joint Ventures,~~ ~~or Topic 323,and~~Derivatives and ~~Hedging,~~Hedging-Contracts in Entity’s Own Equity ~~or Topic 815,~~ ~~- Clarifying the Interactions between Topic 321, Topic 323, and Topic 815,~~ ~~which~~(Subtopic 815-40): Issuer’s Accounting for Certain Modifications or Exchanges of Freestanding Equity-Classified Written Call Options~~addresses the~~, which intends to clarify and reduce diversity in an issuer’s accounting for ~~the transition into and out~~modifications or exchanges of ~~the~~freestanding equity-classified written call options (for example, warrants) that remain equity method and provides clarification of the interaction of rules for equity securities, the equity method of accounting, and forward contracts and purchase options on certain types of securities. The amendments clarify that: (a) an entity should consider observable transactions that require it to either applyclassified after modification or ~~discontinue the equity method of accounting for the purposes of applying the measurement alternative in accordance with Topic 321 immediately~~

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before applying or upon discontinuing the equity method; and (b) an entity should not consider whether, upon the settlement of the forward contract or exercise of the purchased option, individually or with existing investments, the underlying securities would be accounted for under the equity method in Topic 323 or the fair value option in accordance with the financial instruments guidance in Topic 825. The provisions of this guidance are to be applied prospectively upon their effective date. ASU 2020-01 was effective for fiscal years beginning after December 15, 2020, and interim periods within those years. Early adoption was permitted, but required simultaneous adoption of all provisions of this guidance.exchange. The Company adopted ~~this guidance as of~~ASU 2021-04 on January 1, ~~2021, which did not result in a material impact on its condensed consolidated financial statements and related disclosures.~~

~~In December 2019, the FASB issued ASU 2019-12,~~ ~~Income Taxes~~: ~~Simplifying the Accounting for Income Taxes,~~ or Topic 740, which simplifies the accounting for income taxes by removing certain exceptions to the general principles in Topic 740. ASU 2019-12 also improves consistent application and simplification of other areas of Topic 740 by clarifying and amending existing guidance. ASU 2019-12 was effective for fiscal years beginning after December 15, 2020. The Company adopted this guidance as of January 1, 2021,2022, which did not result in a material impact on its condensed consolidated financial statements and related disclosures.

~~In August 2020, the FASB issued ASU 2020-06,~~ ~~Debt—Debt with Conversion and Other Options,~~ ~~or Subtopic 470-20 and~~ ~~Derivatives and Hedging—Contracts in Entity’s Own Equity,~~ or~~Subtopic 815-40:~~ ~~Accounting for Convertible Instruments and Contracts in an Entity’s Own Equity,~~ ~~which simplifies the accounting for certain financial instruments with characteristics~~Table of liabilities and equity, including convertible instruments and contracts on an entity’s own equity. Specifically, ASU 2020-06 simplifies accounting for the issuance of convertible instruments by removing major separation models required under current GAAP. In addition, the ASU removes certain settlement conditions that are required for equity contracts to qualify for the derivative scope exception and simplifies the diluted earnings per share, or EPS, calculation in certain areas. ASU 2020-06 will be effective for fiscal years beginning after December 15, 2023, including interim periods within those fiscal years. Early adoption is permitted, beginning in fiscal years which begin after December 15, 2020, including interim periods within those fiscal years. The Company early adopted ASU 2020-06 under a modified retrospective approach as of January 1, 2021. As a result of the adoption, there was no impact on retained earnings or other components of equity or to earnings per share in the Company’s condensed consolidated financial statements.Contents

2. OTHER FINANCIAL INFORMATION

Prepaid Expense and Other Current Assets

Prepaid expense and other current assets were comprised of the following (in thousands):

AS OF AS OF
SEPTEMBER 30, 2021 DECEMBER 31, 2020
Outside research and development services $ 4,732 $ 2,204
Deferred offering costs 346 —
Other 747 689
Prepaid expense and other current assets $ 5,825 $ 2,893

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	AS OF		AS OF
	JUNE 30, 2022		DECEMBER 31, 2021

Outside research and development services	$	4,345	$	6,343


Other	609		590
Prepaid expense and other current assets	$	4,954	$	6,933

Property and Equipment, Net

Property and equipment, net were comprised of the following (in thousands):


		AS OF		AS OF			AS OF		AS OF
		SEPTEMBER 30, 2021		DECEMBER 31, 2020			JUNE 30, 2022		DECEMBER 31, 2021

Machinery and equipment	Machinery and equipment	$	6,202	$	5,652	Machinery and equipment	$	6,819	$	6,286
Leasehold improvements	Leasehold improvements	441		441		Leasehold improvements	441		441
Computer software	Computer software	42		—		Computer software	42		42
Furniture and fixtures	Furniture and fixtures	514		507		Furniture and fixtures	514		514
Construction in process	Construction in process	82		257		Construction in process	78		281
Total property and equipment	Total property and equipment	7,281		6,857		Total property and equipment	7,894		7,564
Less: accumulated depreciation and amortization	Less: accumulated depreciation and amortization	(4,103)		(3,365)		Less: accumulated depreciation and amortization	(5,016)		(4,411)
Property and equipment, net	Property and equipment, net	$	3,178	$	3,492	Property and equipment, net	$	2,878	$	3,153

Depreciation and amortization expense totaled $0.3 million for each of the three months ended ~~September~~June 30, 2022 and June 30, 2021 and ~~2020, and $0.9 million and $0.8~~$0.6 million for each of the ~~nine~~six months ended ~~September~~June 30, 2022 and June 30, 2021, and ~~2020, respectively.~~consisted of the following (in thousands):


	THREE MONTHS ENDED JUNE 30,				SIX MONTHS ENDED JUNE 30,
	2022		2021		2022		2021
Research and development	$	248	$	251	$	506	$	496
General and administrative	59		47		108		93
Total depreciation and amortization expense	$	307	$	298	$	614	$	589

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Accrued Expenses

Accrued expenses were comprised of the following (in thousands):

AS OF AS OF
SEPTEMBER 30, 2021 DECEMBER 31, 2020
Accrued research and development $ 6,138 $ 11,529
Accrued compensation expense 1,114 1,165
Accrued professional fees 476 282
Other 598 381
Accrued expenses $ 8,326 $ 13,357


	AS OF		AS OF
	JUNE 30, 2022		DECEMBER 31, 2021

Clinical trials(1)	$	3,739	$	4,496
Clinical drug substance and product manufacturing(2)	3,816		1,564
Other outside research and development	1,353		1,329
Compensation-related	1,606		1,322
Professional fees	944		261

Other	1,014		649
Accrued expenses	$	12,472	$	9,621

~~The amount accrued for research and development expense relates~~(1) Relates primarily to the Company’s usage of third-party CROs for management of clinical trials. See Note 1 for further discussion of the components of research and development.

(2) Relates primarily to the Company’s usage of third-party CDMOs for clinical and development ~~efforts as its therapeutic candidates progress.~~efforts. See Note 1 for further discussion of the components of research and development.

3. DEBT

2020 Loan Agreement

On July 15, 2020, the Company entered into a loan and security agreement, or the 2020 Loan Agreement, with Oxford Finance LLC, or Oxford, pursuant to which it received $10.0 million in gross proceeds, ~~net of $0.1 million of debt issuance costs.~~

~~On November 12, 2020, the Company entered into an amendment to the~~or Term A. The 2020 Loan Agreement was subsequently amended in November 2020, or the November 2020 Amendment, ~~and received $20.0 million in additional gross proceeds, net of $0.02 million of debt issuance costs and $0.7 million of~~upon which a one-time first amendment fee. The November 2020 Amendment provided for 2 additional tranches of term loans, in addition to the first $10.0 million tranche, or Term A, for an aggregate principal amount of up to $50.0 million, as follows: (a) the second tranche in an aggregate principal amount of $20.0 million was funded, ~~upon the closing of the November 2020 Amendment,~~ or Term B, and ~~(b)~~in June 2021, or the June 2021 Amendment, upon which a third tranche in an aggregate principal amount of ~~$20.0~~$40.0 million to fund on or before September 30, 2021, subject to the initiation of a potentially registration-enabling trial for the Company’s therapeutic candidate, INBRX-109, in unresectable or metastatic conventional chondrosarcoma, pursuant to the terms of the November 2020 Amendment,was funded, or Term C. ~~The terms of Term A under the 2020 Loan Agreement were modified to align with Term B pursuant to the November 2020 Amendment.~~

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~~On June 18, 2021,~~In February 2022, the Company entered into an additional amendment, or the February 2022 Amendment, to the 2020 Loan Agreement, ~~or the June 2021 Amendment (collectively with the November 2020 Amendment,~~collectively, the Amended 2020 Loan ~~Agreement). Pursuant~~Agreement, upon which the Company received gross proceeds of $40.0 million, or Term D, net of $1.1 million of legal and amendment fees.

The February 2022 Amendment also provided for an increase in the interest rate and for 3 future tranches of debt to be funded upon the achievement of certain milestones. In June ~~2021 Amendment,~~2022, the ~~principal amount~~Company received additional gross proceeds of ~~the~~$30.0 million, or Term C Loan was increased from $20.0 million to $40.0 million. All terms of the Term C Loan align with the existing terms of the Term A and Term B Loans. Upon execution of the June 2021 Amendment and based onE, following the initiation of ~~a potentially registration-enabling~~part 4 of the Phase 1 clinical trial ~~in unresectable or metastatic conventional chondrosarcoma, the Company drew the Term C Loan and received $40.0~~of INBRX-105, as well as an additional $30.0 million in gross proceeds, ~~net~~or Term F, following the receipt of ~~$0.01~~positive topline data from the Phase 1 clinical trial of INBRX-101. NaN additional tranche with an aggregate principal amount of $30.0 million, or Term G, remains available to the Company, which will be funded subject to the initiation of ~~debt issuance costs.~~the registrational clinical trial of INBRX-101 on or before June 30, 2023.

The Company determined the November 2020, June 2021, and February 2022 Amendments should be treated as modifications of the original 2020 Loan Agreement since the terms and resulting cash flows were not substantially changed upon each of the amendments.

As of ~~September~~June 30, ~~2021,~~2022, the Company ~~has $70.0~~had $170.0 million in gross principal outstanding in term loans under the Amended 2020 Loan Agreement. The outstanding term loans will mature on ~~November~~January 1, ~~2025,~~2027, or the Amended Maturity Date, and bear interest at a floating per annum rate equal to the greater of (1) ~~7.96% and~~8.30% or (2) the sum of (i) the 30 day U.S. Dollar LIBOR rate reported in The Wall Street Journal on the last business day of the month that immediately precedes the month in which the interest will accrue, plus (ii) ~~7.80%~~8.19%. The repayment schedule provides for interest-only payments ~~until January~~through February 1, 2025. The interest-only period is followed by 1123 months of equal payments of principal and ~~interest.~~interest beginning on March 1, 2025. The interest-only period may be extended by an additional 12 months in the event the Company raises at least $100.0 million in upfront licensing or partnership proceeds by February 2025, which would then be followed by 11 months of principal repayments. Upon the Amended Maturity Date, a final payment of 9.0% of the original principal amount will be due to Oxford. This final payment of ~~$6.3~~$15.3 million is being accreted over the life of the Amended 2020 Loan Agreement using the effective interest method. The Company has the option to prepay the outstanding balance of the term loans in full prior to the

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Amended Maturity Date, subject to a prepayment fee ranging from 1.0% to 3.0%, depending upon the timing of the prepayment. ~~All other terms of the original 2020 Loan Agreement remain outstanding.~~

The Company’s outstanding debt balance under the Amended 2020 Loan Agreement consisted of the following as of June 30, 2022 and December 31, 2021 (in thousands).


		AS OF		AS OF			AS OF		AS OF
		SEPTEMBER 30, 2021		DECEMBER 31, 2020			JUNE 30, 2022		DECEMBER 31, 2021
Term A	Term A	$	10,900	$	10,900	Term A	$	10,900	$	10,900
Term B	Term B	21,800		21,800		Term B	21,800		21,800
Term C	Term C	43,600		—		Term C	43,600		43,600
Term D						Term D	43,600		—
Term E						Term E	32,700		—
Term F						Term F	32,700		—
Less: debt discount	Less: debt discount	(6,231)		(3,456)		Less: debt discount	(15,500)		(5,830)
Total debt	Total debt	70,069		29,244		Total debt	169,800		70,470
Less: Current portion, including debt discount	Less: Current portion, including debt discount	—		—		Less: Current portion, including debt discount	—		—
Long-term debt, including debt discount		$	70,069	$	29,244
Long-term debt, including debt discount and final payment fee						Long-term debt, including debt discount and final payment fee	$	169,800	$	70,470

~~In November 2020~~As of June 30, 2022, and ~~June 2021, the Company evaluated the amendments and determined they should be treated as modifications of the original 2020 Loan Agreement since~~unless extended in accordance with the terms ~~and resulting cash flow were not substantially changed in either~~described above, the ~~November 2020 Amendment or the June 2021 Amendment. The Company~~Company’s interest-only period will continue ~~to amortize the existing debt discounts prior to modification~~ through ~~the Amended Maturity Date.~~January 2025, with principal payments beginning in February 2025. Future principal payments and final fee payments will be made as follows (in thousands):


	AS OF
	JUNE 30, 2022
2025	$	73,913
2026	88,696
2027	22,691
Total future minimum payments	185,300
Less: unamortized debt discount	(15,500)
Total debt	$	169,800

The Company’s obligations under the Amended 2020 Loan Agreement are secured by a first priority security interest of substantially all of the Company’s assets ~~other than its~~with a positive lien on intellectual property. The Amended 2020 Loan Agreement includes customary events of default, including instances of a material adverse change in the Company’s operations, that may require prepayment of the outstanding term loans. Additionally, ~~following the June 2021 Amendment,~~ the Amended 2020 Loan Agreement requires a minimum cash balance of $20.0 million to be maintained in a collateral account. As of ~~September~~June 30, ~~2021,~~2022, the Company is in compliance with all covenants under the Amended 2020 Loan Agreement and has not received any notification or indication from Oxford of an intent to declare the loan due prior to maturity.

Concurrently with the ~~debt issuance in July 2020,~~February 2022 Amendment, the Company issued 40,000 warrants to Oxford ~~warrants~~ to purchase shares of the Company’s ~~capital~~common stock ~~equal to 1.25%~~at an exercise price of ~~the funded amount, or $125,000.~~$45.00. Upon issuance, the warrants were ~~exercisable for preferred stock and were~~ classified as ~~liabilities pursuant to Topic ASC 480~~equity and recorded at their fair value of ~~$0.12~~$0.7 million. ~~Upon the consummation~~See Note 4 for further discussion of ~~the Company’s IPO in August 2020, the Company remeasured the warrants and determined a fair value of approximately $0.14 million. The change in fair value was recorded as a~~

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change in fair value of warrant liabilities within other income in the Company’s condensed consolidated statements of operations during the third quarter of 2020. As of September 30, 2021, the warrants are equity-classified and are exercisable for 7,354 shares of common stock of the Company at a strike price of $17.00 per share.these warrants.

Interest Expense

Interest expense is calculated using the effective interest method and is inclusive of non-cash amortization of the debt discount and accretion of the final payment. Interest expense was approximately ~~$1.8~~$3.2 million and ~~$3.6~~$1.0 million for the three ~~and nine~~ months ended ~~September~~June 30, 2022 and June 30, 2021 and $5.5 million and $1.7 million for the six months ended June 30, 2022 and June 30, 2021, respectively, asall of which was related to the Amended 2020 Loan Agreement. Interest expense is calculated using the effective interest method and is inclusive of non-cash amortization of the debt discount and accretion of the final payment. Interest expense was approximately $0.3 million for the three and nine months ended September 30, 2020, as related to the Amended 2020 Loan Agreement. Interest expense related to the Company’s previous loan and security agreement, as amended, or the 2015 Loan Agreement with Oxford, was approximately $44,000 for the nine months ended September 30, 2020. The Company recorded no interest expense for the three months ended September 30, 2020 related to the 2015 Loan Agreement since it was paid in ~~full in March 2020.~~

~~4. CONVERTIBLE PROMISSORY NOTES~~

In May 2019, the Company issued a convertible promissory note, or the 2019 Note, in the aggregate principal amount of $40.0 million to DRAGSA 50, LLC, an entity affiliated with Viking Global Investors LP, or Viking, in a private placement transaction. The 2019 Note began to accrue interest in February 2020 at a rate of 1.5% per month. In April 2020, the Company issued convertible promissory notes, or the 2020 Notes, in the aggregate principal amount of $15.0 million to Viking and certain other investors in a private placement transaction. Upon issuance, the 2020 Notes accrued interest at a rate of 1.0% per month.

~~Conversion Upon IPO~~

On August 21, 2020, the Company completed its IPO. The aggregate total balance of the 2019 Note, or $43.7 million, converted at the fixed price of $14.35 per share, resulting in the issuance of 3,046,467 shares of common stock to the holder. The aggregate total balance of the 2020 Notes, or $15.7 million, converted at a fixed price of $12.56 per share, resulting in the issuance of 1,248,136 shares of common stock to the holders.

~~Debt Discount and Derivative Liabilities~~

~~Upon issuance of the 2019 Note and the 2020 Notes, the Company recorded debt discounts related to beneficial conversion features, or BCFs, as well as derivative liabilities and debt issuance costs.~~

Upon conversion of the 2019 Note and the 2020 Notes, the Company remeasured the intrinsic value of the BCFs which resulted in a reversal of the remaining unamortized discounts associated with the BCFs, resulting in a $7.4 million impact to additional paid-in-capital. Additionally, the Company accelerated the unamortized debt discounts related to the debt issuance costs and the derivative liabilities, resulting in a $2.2 million charge to interest expense during the third quarter of 2020.

~~5. STOCKHOLDERS’ EQUITY~~

~~Amended and Restated Certificate of Incorporation~~

On August 21, 2020, upon completion of the IPO, the Company’s certificate of incorporation was amended and restated to authorize 120,000,000 shares of common stock and 15,000,000 shares of preferred stock, each ~~with a par value of $0.0001 per share.~~

~~Convertible Preferred Stock~~

In connection with the completion of the Company’s IPO in August 2020, all of the outstanding shares of convertible preferred stock were converted into 7,211,086 shares of the Company’s common stock. Prior to its conversion to common stock, the convertible preferred stock was classified as temporary, or mezzanine, equity on the accompanying condensed consolidated balance sheets since the shares contained certain redemption features that were not solely within the control of the Company. The Company had not previously accreted the convertibleperiod.

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~~preferred stock to its redemption value since the shares were not currently redeemable and redemption was not deemed to be probable.~~

~~No convertible preferred stock was authorized or issued as of September 30, 2021 and December 31, 2020.~~4. STOCKHOLDERS’ EQUITY

Common Stock

In September 2021, the Company entered into the Sales Agreement with the Sales Agent, under which it may, from time to time, sell shares of its common stock having an aggregate offering price of up to $200.0 million through the Sales Agent, or the ATM Offering. Pursuant to the Sales Agreement, the Company will pay the Sales Agent a commission for its services in acting as an agent in the sale of common stock in an amount equal to 3% of the gross sales price per share sold. NoDuring the year ended December 31, 2021, the Company sold 921,042 shares ~~have been sold~~pursuant to the Sales Agreement for net proceeds of $40.2 million, after deducting commissions. During the six months ended June 30, 2022, the Company did not issue any shares under the ~~ATM Offering as of September 30, 2021.~~Sales Agreement.

Common Stock Warrants

~~As discussed in Note 3, the~~The Company ~~issued~~has 7,354 warrants ~~to Oxford concurrently with the 2020 Loan Agreement. Upon the consummation~~outstanding at an exercise price of ~~the Company’s IPO in August 2020, the warrants became~~$17.00 per share, which are exercisable for ~~7,354~~ shares of common stock through their expiration date of ~~the Company at $17.00 per share.~~July 15, 2030. As of ~~September~~June 30, ~~2021,~~2022, the warrants are equity-classified and reflected in additional paid-in-capital at ~~$0.14~~a fair value of $0.1 million.

Upon the February 2022 Amendment, the Company issued 40,000 warrants, which are exercisable for shares of common stock of the Company at $45.00 per share. The warrants are exercisable through their expiration date of February 18, 2032. The warrants are equity-classified and reflected in additional paid-in-capital at a fair value of $0.7 million. The fair value of the warrants was determined using the Black-Scholes model on the date of ~~reclassification.~~ issuance.

No subsequent remeasurement is required for equity-classified warrants.

6.5. EQUITY COMPENSATION PLAN

Stock Incentive Plan

The Company’s share-based compensation plan, the Amended and Restated 2017 Employee, Director and Consultant Equity Incentive Plan, or the 2017 Plan, provides for the issuance of incentive stock options, restricted and unrestricted stock awards, and other stock-based awards. As of ~~September~~June 30, ~~2021,~~2022, an aggregate of ~~4.5~~6.1 million shares of common stock were reserved for issuance under the 2017 Plan, of which ~~0.3~~0.5 million were available.

Stock Option Activity

The Company recognizes compensation costs related to stock-based awards, including stock options, based on the estimated fair value of the awards on the date of grant. The Company grants options with an exercise price equal to the fair market value of the Company’s stock on the date of the option grant. The options are subject to four-year vesting with a one-year cliff and have a contractual term of 10 years.

A summary of the Company’s stock option activity under its 2017 Plan for the ~~nine~~six months ended ~~September~~June 30, ~~2021~~2022 is as follows (in thousands, except for per share data and years):


		Number of Shares	Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (In Years)	Aggregate Intrinsic Value			Number of Shares	Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (In Years)	Aggregate Intrinsic Value

Outstanding as of December 31, 2020		2,525	$	11.80
Outstanding as of December 31, 2021								Outstanding as of December 31, 2021	4,064	$	22.19
Granted	Granted	2,079	$	31.75				Granted	1,407	$	25.95
Exercised	Exercised	(221)	$	11.06				Exercised	(51)	$	11.19
Forfeited	Forfeited	(400)	$	23.18				Forfeited	(224)	$	28.50
Outstanding as of September 30, 2021		3,983	$	21.11	8.3	$	49,078
Vested and exercisable as of September 30, 2021		1,227	$	11.00	6.7	$	27,367
Outstanding as of June 30, 2022								Outstanding as of June 30, 2022	5,196	$	23.04	8.1	$	1,016
Vested and exercisable as of June 30, 2022								Vested and exercisable as of June 30, 2022	2,014	$	17.40	6.7	$	832

The aggregate intrinsic value of stock options exercised during the ~~nine~~six months ended ~~September~~June 30, 2022 and June 30, 2021 was ~~$3.4 million.~~$1.0 million and $1.7 million, respectively. Aggregate intrinsic value of stock options exercised and

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outstanding is calculated using the fair value of common stock at

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~~September 30, 2021. The aggregate intrinsic value of stock options exercised is calculated using~~on the ~~fair value of common stock at each~~ date of ~~exercise.~~exercise and as of June 30, 2022, respectively.

Stock-Based Compensation Expense

The weighted-average assumptions used by the Company to estimate the fair value of stock option grants using the Black-Scholes option pricing model, as well as the resulting weighted-average fair value for the ~~nine~~six months ended ~~September~~June 30, ~~2021~~2022 and ~~2020~~June 30, 2021 were as follows:


		NINE MONTHS ENDED SEPTEMBER 30,							SIX MONTHS ENDED JUNE 30,
		2021			2020				2022			2021

Risk-free interest rate	Risk-free interest rate	0.67		%	0.41		%	Risk-free interest rate	2.17		%	0.65		%
Expected volatility	Expected volatility	93.55		%	97.78		%	Expected volatility	85.12		%	93.62		%
Expected dividend yield	Expected dividend yield	—		%	—		%	Expected dividend yield	—		%	—		%
Expected term		6.08			6.08
Expected term (in years)								Expected term (in years)	6.08			6.08
Weighted average fair value	Weighted average fair value	$	24.01		$	9.33		Weighted average fair value	$	18.75		$	24.23

Stock-based compensation expense for stock options consisted of the following (in thousands):


		THREE MONTHS ENDED SEPTEMBER 30,				NINE MONTHS ENDED SEPTEMBER 30,					THREE MONTHS ENDED JUNE 30,				SIX MONTHS ENDED JUNE 30,
		2021		2020		2021		2020			2022		2021		2022		2021
Research and development	Research and development	$	2,696	$	1,103	$	8,679	$	3,149	Research and development	$	3,540	$	3,209	$	7,219	$	5,983
General and administrative	General and administrative	797		200		2,186		501		General and administrative	1,756		742		3,185		1,389
Total stock-based compensation expense	Total stock-based compensation expense	$	3,493	$	1,303	$	10,865	$	3,650	Total stock-based compensation expense	$	5,296	$	3,951	$	10,404	$	7,372

As of ~~September~~June 30, ~~2021,~~2022, the Company had ~~$45.4~~$58.3 million of total unrecognized stock-based compensation expense related to its stock options, which is expected to be recognized over a weighted-average period of ~~3.1~~3.0 years.

7.6. LICENSE AND GRANT REVENUES

The following table summarizes the total revenue recorded in the Company’s condensed consolidated statements of operations (in thousands):

THREE MONTHS ENDED
SEPTEMBER 30, NINE MONTHS ENDED
SEPTEMBER 30,
2021 2020 2021 2020
License fee revenue from affiliates
Elpiscience Biopharmaceuticals, Inc. $ — $ 2,000 $ — $ 2,000
Total license fee revenue from affiliates — 2,000 — 2,000
License fee revenue
Phylaxis BioScience, LLC 460 809 1,838 809
2seventy bio, Inc. 2,000 — 2,100 400
Chiesi Farmaceutici S.p.A. 48 1,967 351 5,773
Other license revenues from non-affiliates — 1,050 — 1,050
Total license fee revenue 2,508 3,826 4,289 8,032
Grant revenue 24 75 86 80
Total revenue $ 2,532 $ 5,901 $ 4,375 $ 10,112

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	THREE MONTHS ENDED JUNE 30,				SIX MONTHS ENDED JUNE 30,
	2022		2021		2022		2021




License fee revenue
Phylaxis BioScience, LLC	$	413	$	737	$	1,087	$	1,378
2seventy bio, Inc.	200		100		200		100
Chiesi Farmaceutici S.p.A.	98		81		339		303

Total license fee revenue	711		918		1,626		1,781




Grant revenue	—		36		14		62
Total revenue	$	711	$	954	$	1,640	$	1,843

License and Collaboration Agreements

~~Elpiscience~~

In April 2018, the Company entered into a License Agreement, or the OX40 License Agreement, with Elpiscience Biopharmaceuticals, Inc., or Elpiscience, whereby the Company granted Elpiscience an exclusive license to the Company’s multivalent protein therapeutic directed to the biological target OX40, or INBRX-106. This license provides Elpiscience with the right to further advance the therapeutic candidate through clinical trials, as well as to manufacture and commercialize it, in China, Hong Kong, Macau and Taiwan. It also requires the Company to provide Elpiscience with know-how and materials specific to INBRX-106, including process development and manufacturing data and information necessary to develop INBRX-106. In the OX40 License Agreement, the Company also agreed to negotiate an agreement to supply Elpiscience with INBRX-106 for its development in Mainland China, Hong Kong, Macau and Taiwan. The Company is eligible to receive certain developmental and commercial milestone payments of up to an aggregate of $100.0 million, as well as percentage tiered royalties on future product sales with rates in the high single-digits. Due to the uncertainty in the achievement of the developmental and commercial milestones, the variable consideration associated with the future milestone payments has been fully constrained (excluded) from the transaction price until such time that the Company concludes that it is probable that a significant reversal of previously recognized revenue will not occur. This will be re-assessed at each reporting period.

In September 2020, the Company achieved a milestone event under the OX40 License Agreement for $2.0 million, which was received during September 2020. The Company recognized revenue of $2.0 million during the three and nine months ended September 30, 2020 related to this agreement. During the three and nine months ended September 30, 2021, the Company recognized no revenue related to this agreement.

Phylaxis

In July 2020, the Company entered into a joint venture with an entity affiliated with ArrowMark Partners, Phylaxis BioScience, LLC, or Phylaxis. In connection with the joint venture, the Company entered into the following agreements: Contribution Agreement, License Agreement, Limited Liability Company Agreement, and Master

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Services Agreement, or collectively the Phylaxis Agreements, pursuant to which the Company licensed certain intellectual property and know-how to Phylaxis and agreed to provide services to develop certain compounds. Upon closing, the Company received a $2.5 million nonrefundable, upfront payment from Phylaxis under the Master Services Agreement, or MSA. The Company has also received an additional $2.5 million, which was payable within 180 days from closing under the MSA, in two payments of $1.25 million each, received in October 2020 and January 2021. Upon closing, the Company received a 10% equity interest in Phylaxis as consideration for the contribution of the license of the Company’s intellectual property and know-how and is entitled to receive an additional 5% based on the achievement of certain milestones. Under the License Agreement, the Company is also entitled to specified development and commercialization milestone payments of up to an aggregate of $225.0 million and $175.0 million, respectively. The Company is also entitled to share in a percentage of the profits of Phylaxis under the Limited Liability Company Agreement.

In order to determine the fair value of the equity interest in Phylaxis, the Company engaged a third-party valuation specialist. The valuation report utilized a market approach to establish the total equity value of Phylaxis using inputs not observable in the market, including the discount rate. The fair value of the equity interest was $0.5 million, which has been accounted for under the equity method. The fair value of the equity interest upon the execution of the agreements has been included in the transaction price, along with the $5.0 million of payments due pursuant to the MSA.

The Company identified the transfer of the exclusive licenses for, and performance of, development services to modify the first and second compounds as 1 performance obligation and allocated the transaction price evenly between the 2 compounds. Revenue related to the performance obligation will be recognized over time as services are performed, based on the Company’s progress to satisfy the performance obligation.

During the three ~~and nine~~ months ended ~~September~~June 30, 2022 and June 30, 2021, the Company recognized ~~$0.5~~$0.4 million and ~~$1.8 million, respectively, of revenue related to this performance obligation. During the three and nine months ended September 30, 2020, the Company recognized $0.8~~$0.7 million of revenue related to this performance ~~obligation.~~obligation, respectively. During the six months ended June 30, 2022 and June 30, 2021, the Company recognized $1.1 million and $1.4 million of revenue related to this performance obligation, respectively. As of

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~~September~~ June 30, 2022 and December 31, 2021, deferred revenue related to the Phylaxis Agreements was ~~$1.7~~$14,000 and $1.1 million, respectively, all of which was classified as ~~current. As of December 31, 2020,~~ current and non-current deferred revenue related to the Phylaxis Agreements were $1.6 million and $0.6 million, respectively. The Company expects to complete all work related to these agreements and recognize revenue in its entirety through the second half of 2022.at each date.

2seventy bio, Inc.

~~2018 License Agreement~~

On December 20, 2018, the Company entered into a License Agreement with bluebird bio, Inc., or bluebird, whereby the Company granted bluebird the exclusive, worldwide rights to develop, manufacture, and commercialize certain cell therapy products containing binders. In November 2021, bluebird assigned the agreement, which we refer to as the 2018 2seventy Agreement, to its affiliate, 2seventy bio, Inc., or 2seventy, in connection with an internal restructuring and subsequent spin-out of 2seventy. Under this agreement, the Company is entitled to receive specified development milestone payments of up to an aggregate of $51.5 million per therapeutic, as well as percentage tiered royalties on future product sales with rates in the mid-single-digits. Due to the uncertainty in the achievement of the developmental milestones, the variable consideration associated with the future milestone payments has been fully constrained (excluded) from the transaction price until such time that the Company concludes that it is probable that a significant reversal of previously recognized revenue will not occur. These estimates will be re-assessed at each reporting period.

In July 2021, a milestone event under the 2018 2seventy Agreement was achieved and the Company recognized $2.0 million of revenue at that point in time. The Company received the associated $2.0 million payment in August 2021. During each of the three and nine months ended September 30, 2021, the Company recognized a total of $2.0 million in revenue related to this agreement. During the three and nine months ended September 30, 2020, the Company recognized no revenue related to this agreement.

~~2020 Option and License Agreement~~

In June 2020, the Company entered into an Option and License Agreement with bluebird bio, Inc., or bluebird, pursuant to which the Company granted to bluebird exclusive worldwide ~~development licenses~~rights to develop binders and cell therapy products containing single domain antibodies, or sdAbs, directed to specified targets, consisting of 2 initial programs and up to an additional 8 programs. The Company retains all rights to the specific sdAbs outside of the cell therapy field. This agreement, ~~which we refer to as~~or the 2020 2seventy Agreement, was ~~also~~ assigned to bluebird’s affiliate, 2seventy bio, Inc., or 2seventy, in November 2021 in connection with bluebird’s internal restructuring and subsequent spin-out of 2seventy.

In June 2020, the Company received a non-refundable upfront option fee of $0.2 million in connection with each of the 2 initial programs, or $0.4 million in aggregate, and is entitled to an upfront option fee for each additional program, on a program-by-program basis. ~~The~~In June 2022, 2seventy selected a third program and paid a non-refundable upfront option fee of $0.2 million in exchange for a development license. Under each of the 3 programs, the Company ~~also~~has granted an option in which 2seventy may acquire an exclusive license with respect to all binders and cell therapy products developed under this agreement, which entitles the Company to additional fees upon exercise of the option. In connection with each program for which 2seventy exercises its option, 2seventy will be required to pay the Company a one-time, non-refundable, non-creditable fee in the low-single-digit ~~millions for each option 2seventy chooses to exercise.~~millions. The Company is also entitled to receive certain developmental milestone payments of up to an aggregate of $51.5 million per therapeutic, as well as percentage tiered royalties on future product sales with rates in the mid-single-digits. Due to the uncertainty in the achievement of the developmental milestones and future sales, the variable consideration associated with the future milestone payments has been fully constrained (excluded) from the transaction price until

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such time that the Company concludes that it is probable that a significant reversal of previously recognized revenue will not occur. These estimates will be re-assessed at each reporting period.

As of the effective date of the 2020 2seventy Agreement, the Company identified 1 performance obligation, which was the transfer of the exclusive development license to bluebird for the 2 initial programs. The Company determined that the option granted for an exclusive license in the future was not a material right. For the 8 programs not identified upon execution of the contract, the Company evaluated the customer option for additional purchases and determined that those options for additional programs did not constitute material rights nor variable consideration. As additional programs are identified, the Company ~~will re-assess~~re-assesses its performance obligations and transaction price accordingly.

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The Company determined the total transaction price of the 2020 2seventy Agreement at execution was $0.4 million for the transfer of the 2 exclusive development licenses. The Company recognized $0.4 million of revenue related to this agreement at the point in time in which the exclusive development licenses were transferred to bluebird, which occurred upon execution of the agreement in June 2020.

In May 2021, pursuant to the option extension terms in the 2020 2seventy Agreement, bluebird requested to extend the option term for one of the initial programs by an additional six months in exchange for an option extension fee of $0.1 million. The Company recognized the $0.1 million of revenue related to this extension in May 2021, the point in time in which the extension was granted.

In October 2021, pursuant to the option exercise terms in the 2020 2seventy Agreement, the Company received a $2.1 million option exercise fee for one of the initial programs and transferred an exclusive license for the program and recognized the $2.1 million of revenue related to this option exercise at the point in time in which the exclusive license was transferred.

In June 2022, pursuant to the terms regarding the addition of new programs in the 2020 2seventy Agreement, the Company received a $0.2 million upfront option fee related to the selection of a third program and transferred the related know-how and development license. The Company recognized the $0.2 million of revenue at the point in time in which the program was added and the program term began.

During the ~~nine~~three and six months ended ~~September~~June 30, ~~2021 and 2020,~~2022, the Company recognized ~~$0.1 million and $0.4~~$0.2 million of revenue related to this agreement ~~respectively. No~~in each period. During the three and six months ended June 30, 2021, the Company recognized $0.1 million of revenue ~~was recognized~~ related to this agreement ~~during either of the three months ended September 30, 2021 and 2020.~~in each period.

Chiesi

In May 2019, the Company entered into an Option Agreement, as amended by the First Amendment to Option Agreement, dated August 19, 2019, or the Chiesi Option Agreement, with Chiesi Farmaceutici S.p.A., or Chiesi, pursuant to which the Company granted to Chiesi an exclusive option to obtain an exclusive license to develop and commercialize INBRX-101 outside of the United States and Canada. Additionally, the Chiesi Option Agreement provides Chiesi with a right of negotiation for INBRX-101 development and commercialization rights in the United States and Canada in the event that the Company engages in discussions with any third parties for such rights during the term of the Chiesi Option Agreement or, as applicable, the term of a definitive exclusive license agreement between Chiesi and the Company. Under the terms of the Chiesi Option Agreement, the Company received a one-time, non-refundable option initiation payment of $10.0 million in August 2019. If Chiesi chooses to exercise its option under the Chiesi Option Agreement, then Chiesi must pay the Company a one-time, non-refundable fee of $12.5 million upon the effective date of the definitive agreement granting Chiesi the exclusive license. If the option is exercised, under the license agreement, the Company may be entitled to receive specified milestone payments of up to $122.5 million, as well as royalties on future product sales.

The Company has identified 1 performance obligation as of the effective date of the Chiesi Option Agreement, which is to perform research and development services for Chiesi during the option period, which will continue (unless the Chiesi Option Agreement is terminated earlier by Chiesi or the Company) until 60 days following the last to occur of (i) the Company’s delivery to Chiesi of the trial phase data for the first Phase I Clinical Trial, (ii) the Company’s delivery to Chiesi of the finalized minutes from the definitive U.S. Food and Drug Administration, or FDA, scientific advice meeting conducted following completion of such Phase I Clinical Trial, and (iii) the Company’s delivery to Chiesi of the finalized minutes from the definitive parallel EMA-HTA scientific advice meeting conducted following completion of such Phase I Clinical Trial. The Company has determined that the option to grant a license in the future is not a material right.

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The $10.0 million upfront payment has been allocated to the single performance obligation. Revenue is recognized over time as services are performed during the option period, based on the Company’s effort to satisfy the performance obligation relative to the total expense estimated to be incurred during the option period. During the three months ended ~~September~~June 30, ~~2021~~2022 and ~~2020,~~June 30, 2021, the Company recognized ~~$0.05 million and $2.0~~$0.1 million in revenue related to this agreement ~~respectively.~~in each period. During the ~~nine~~six months ended ~~September~~June 30, ~~2021~~2022 and ~~2020,~~June 30, 2021, the Company recognized ~~$0.4 million and $5.8~~$0.3 million in revenue related to this agreement ~~respectively.~~in each period. As of ~~September~~June 30, 2022, the Company has $0.7 million of deferred revenue related to this agreement, all of which is classified as current. As of December 31, 2021, the Company ~~has $1.1~~had $0.9 million and $0.1 million of current and non-current deferred revenue related to this agreement, respectively. As of December 31, 2020, the Company had $1.4 million and $0.1 million of current and non-current deferred revenue related to this agreement, respectively. The Company expects to complete all work related to this contract and recognize revenue in its entirety through the second half of 2022.

8.7. RELATED PARTY TRANSACTIONS

From time to time, the Company will enter into an agreement with a related party in the ordinary course of its business. These agreements are ratified by the Company’s Board of Directors or a committee thereof pursuant to policy.

LAV Summit Limited

LAV Summit Limited, or LAV SL, a limited company, is a principal shareholder ~~owning~~which owned more than 5% of the Company’s outstanding equity interest ~~as of September 30, 2021 and~~during the year ended December 31, ~~2020.~~2021. Due to this equity ownership, LAV SL iswas considered a related party. LAV SL’s General Partner, Lilly Asia Ventures, or LAV, through

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one of its funds, holds a significant equity ownership position in Chinese biotechnology company, Elpiscience Biopharmaceuticals, Inc., or Elpiscience, and the Venture Partner of LAV is the CEO, Founder, and Director at Elpiscience. Accordingly, the Company ~~identifies~~identified Elpiscience as a related ~~party.~~party and all agreements entered into between the Company and Elpiscience through December 31, 2021 are deemed related party agreements. As of December 31, 2021, LAV SL no longer held more than 5% of the Company’s outstanding equity interest, accordingly, any future contracts entered into with LAV SL affiliates will not be considered related party transactions.

Elpiscience

In April 2018, the Company entered into a license agreement, or the OX40 License Agreement, with Elpiscience, whereby the Company granted Elpiscience an exclusive license to the Company’s multivalent protein therapeutic directed to the biological target OX40, or INBRX-106. Under this agreement, the Company is entitled to reimbursement for certain CMC and toxicology expenses ~~incurred for which Elpiscience~~incurred. The Company received $0.2 million in reimbursements under this agreement during the first quarter of 2022, and has ~~paid the Company approximately $5.2~~received $5.3 million to date as of ~~September~~June 30, ~~2021.~~2022. As of ~~September~~June 30, 2021, the Company has $0.2 million recorded as receivables from related parties from Elpiscience for expenses incurred which have not yet been reimbursed. During the three and nine months ended September 30, 2021, the Company received no reimbursements for expenses already incurred. During the three months ended September 30, 2020, the Company received no reimbursements for expenses already incurred. During the nine months ended September 30, 2020, the Company received2022, reimbursements of ~~$0.2 million for expenses already incurred. During the three and nine months ended September 30, 2021, the Company derecognized~~ approximately ~~$45,000 and $0.1 million of expenses~~$38,000 related to ~~these reimbursements~~multi-year stability studies remain, which will be recognized and paid upon completion. Reimbursements under the OX40 License Agreement. During the three and nine months ended September 30, 2020, the Company derecognized approximately $0.1 million and $0.2 million of expenses related to these reimbursements under the OX40 License Agreement, respectively.this contract are recognized as contra-expense as incurred.

In July 2020, the Company entered into an additional cost sharing agreement with Elpiscience related to the OX40 License Agreement. Under this agreement, the Company is entitled to reimbursement for certain formulation development costs. ~~Through September 30,~~The Company received $0.3 million and $0.2 million in reimbursements under this agreement in the first quarter of 2022 and 2021, ~~the Company~~respectively, and has received ~~$0.2~~$0.5 million of reimbursements ~~for expenses already incurred~~to date as of June 30, 2022. Reimbursements under this ~~agreement. As of September 30, 2021, the Company has approximately $0.1 million recorded~~contract are recognized as receivables from related parties from Elpiscience for expenses incurred which have not yet been reimbursed. During the three months ended September 30, 2021, the Company received no reimbursements. During the nine months ended September 30, 2021, the Company received reimbursements of $0.2 million for expenses alreadycontra-expense as incurred. During the three and nine months ended September 30, 2021, the Company did not derecognize any expenses related to this agreement. During the three and nine months ended September 30, 2020, the Company received no reimbursements. During the three and nine months ended September 30, 2020, the Company derecognized $0.1 million of expenses related to this agreement.

In July 2021, the Company entered into a Sale and Purchase Agreement with Elpiscience, in which the Company sold drug substance supply to Elpiscience for approximately $37,000, for which it derecognized expenses during the three and nine months ended September 30, 2021. As of September 30, 2021, the Company has $37,000 recorded as receivables from related parties for this purchase.

9.8. COMMITMENTS AND CONTINGENCIES

Operating Leases

In September 2017, the Company entered into a seven-year lease agreement for approximately 34,000 square feet as its sole location in La Jolla, California. The lease expires in June 2025 with an option to extend the lease an additional five years. The lease contained an initial base rent of approximately $0.1 million per month with 2% annual escalations, plus a percentage of taxes and operating expenses incurred by the lessor in connection with the ownership and management of the property, the latter of which to be determined annually.

In May 2019, the Company executed an amendment to its lease agreement to expand its facilities by approximately 9,000 square feet and began occupying this space in January 2020. The amended lease terminates coterminously with the initial lease agreement and contains an initial base rent of approximately $30,000 per month with 2%

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annual escalations, plus a percentage of taxes and operating expenses incurred by the lessor in connection with the ownership and management of the property, the latter of which is to be determined annually.

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The right-of-use asset and operating lease liability as of ~~September~~June 30, ~~2021~~2022 and December 31, ~~2020~~2021 are as follows (in thousands):


		AS OF		AS OF			AS OF		AS OF
		SEPTEMBER 30, 2021		DECEMBER 31, 2020			JUNE 30, 2022		DECEMBER 31, 2021

Right-of-use asset	Right-of-use asset	$	6,723	$	7,831	Right-of-use asset	$	5,545	$	6,338

Operating lease liability	Operating lease liability					Operating lease liability
Current	Current	$	1,630	$	1,503	Current	$	1,765	$	1,674
Non-current	Non-current	5,469		$	6,707	Non-current	4,131		$	5,033
Total operating lease liability	Total operating lease liability	$	7,099	$	8,210	Total operating lease liability	$	5,896	$	6,707

During the three and ~~nine~~six months ended ~~September~~June 30, 2022, the Company recognized operating lease expense of $0.8 million and $1.6 million, respectively. During the three and six months ended June 30, 2021, the Company recognized operating lease expense of $0.8 million and ~~$2.3~~$1.5 million, respectively. During the three ~~and nine~~ months ended ~~September~~June 30, ~~2020,~~2022 and June 30, 2021, the Company ~~recognized operating~~paid $0.5 million for amounts included in the measurement of the lease ~~expense~~liability in each period. During the six months ended June 30, 2022 and June 30, 2021, the Company paid $1.1 million for amounts included in the measurement of ~~$0.8 million and $2.3 million, respectively.~~ the lease liability in each period.

As of ~~September~~June 30, ~~2021~~2022 and December 31, ~~2020,~~2021, the Company’s operating lease had a remaining term of ~~3.8~~3.0 and ~~4.5~~3.5 years, respectively.

The Company discounts its lease payments using its incremental borrowing rate as of the commencement of the lease. The Company has determined a weighted-average discount rate of 8.2% as of ~~September~~June 30, ~~2021~~2022 and December 31, ~~2020.~~2021.

Future minimum rental ~~payments under~~commitments for the Company’s operating leases reconciled to the lease liability are as follows (in thousands):


		AS OF			AS OF
		SEPTEMBER 30, 2021			JUNE 30, 2022

Remainder of 2021		$	534
2022	2022	2,161		2022	$	1,089
2023	2023	2,203		2023	2,203
2024	2024	2,247		2024	2,247
2025	2025	1,137		2025	1,137
Thereafter	Thereafter	—		Thereafter	—
Total future minimum lease payments	Total future minimum lease payments	$	8,282	Total future minimum lease payments	$	6,676
Less: imputed interest	Less: imputed interest	(1,183)		Less: imputed interest	(780)
Present value of operating lease liability	Present value of operating lease liability	7,099		Present value of operating lease liability	5,896
Less: current portion of operating lease liability	Less: current portion of operating lease liability	(1,630)		Less: current portion of operating lease liability	(1,765)
Non-current portion of operating lease liability	Non-current portion of operating lease liability	$	5,469	Non-current portion of operating lease liability	$	4,131

Litigation

The Company is not party to any material legal proceedings. From time to time, it may be involved in legal proceedings or subject to claims incident to the ordinary course of business. Regardless of the outcome, such proceedings or claims can have an adverse impact on the Company because of defense and settlement costs, diversion of resources and other factors, and there can be no assurances that favorable outcomes will be obtained.

~~10. SUBSEQUENT EVENTS~~

For the unaudited interim condensed consolidated financial statements as of September 30, 2021, the Company evaluated subsequent events to assess the need for potential recognition or disclosure in these financial statements. Based upon this evaluation, it was determined that no additional subsequent events required recognition or disclosure in these condensed consolidated financial statements, other than disclosures related to those outlined below.

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~~In November 2021, the Company sold 921,042 shares of its common stock pursuant to its Sales Agreement for net proceeds of $40.2 million after deducting commissions.~~

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Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations.

You should read the following discussion and analysis of our financial condition and results of operations together in conjunction with our condensed consolidated financial statements and related notes appearing elsewhere in this Quarterly Report, ~~on Form 10-Q, or Quarterly Report,~~ and our audited financial statements and notes thereto as of and for the year ended December 31, ~~2020~~2021 and the related Management’s Discussion and Analysis of Financial Condition and Results of Operations, both of which are contained in our Annual Report on Form 10-K for the fiscal year ended December 31, ~~2020,~~2021, filed with the ~~Securities and Exchange Commission~~SEC on ~~March 12, 2021.~~February 28, 2022. Some of the information contained in this discussion and analysis or set forth elsewhere in this Quarterly Report contain forward-looking statements that involve risk and uncertainties, including those described in the section titled “Special Note Regarding Forward-Looking Statements.” As a result of many factors, including those factors set forth in the section of this Quarterly Report titled “Risk Factors,” our actual results could differ materially from the results described in or implied by the forward-looking statements contained in the following discussion and analysis.

Overview

We are a clinical-stage biotechnology company with a pipeline of novel biologic therapeutic candidates, developed using our protein engineering expertise and proprietary single domain antibody, or sdAb, platform. Our sdAb platform allows us to pursue validated targets with clinical promise ~~but~~ where other antibody and biologic based approaches have failed. Highly modular, our sdAbs can be combined with precise valencies and multiple specificities, creating therapeutic candidates designed to be capable of enhanced cell signaling, conditional activation or combined synergistic functions.

We have multiple programs in various stages of development from discovery to preclinical to clinical. We currently have four programs in ongoing clinical trials. Three of these programs are for the treatment of various cancers, and one for the treatment of Alpha-1 Antitrypsin Deficiency, or AATD. INBRX-101 is an optimized, recombinant alpha 1 antitrypsin, or AAT, augmentation therapy candidate for AATD. In October 2021, we announced interim results from the Phase 1 clinical trial. The data from the single ascending dose cohorts revealed the potential to achieve normal AAT levels with monthly dosing and also showed a favorable safety and tolerability profile with no drug-related severe or serious adverse events at doses up to and including 120 mg/kg single dose and 80 mg/kg multi-dose administered intravenously.

Our most advanced therapeutic candidate, INBRX-109, is a tetravalent death receptor 5, or DR5, agonist currently being evaluated in patients diagnosed with difficult-to-treat cancers, such as chondrosarcoma, mesothelioma and pancreatic adenocarcinoma. We submitted an amended Investigational New Drug Application, or IND, to the U.S. Food and Drug Administration, or FDA, for INBRX-109 in April 2021 and initiated a potentially registration-enabling trial evaluating INBRX-109 in patients diagnosed with conventional chondrosarcoma in June 2021. INBRX-106 is a hexavalent OX40 agonist, currently being investigated as a single agent and in combination with Keytruda, a PD-1 blocking checkpoint inhibitor, in patients with locally advanced or metastatic solid tumors. Both of the INBRX-109 and INBRX-106 programs are designed to achieve target agonism through precise control of therapeutic valency. INBRX-105 is a conditional 4-1BB agonist that is currently being investigated as a single agent and in combination with Keytruda in patients with locally advanced or metastatic solid tumors. We anticipate additional data releases from all four of our clinical programs over the next year.

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~~We have developed a diverse pipeline of therapeutic candidates that are specifically designed to leverage the power of our core sdAb platform and protein engineering expertise,~~AATD, as shown below:

INBRX-101

INBRX-109

INBRX-106

INBRX-105

AAT-Fc fusion protein

Tetravalent DR5 agonist

Hexavalent OX40 agonist

PD-L1x4-1BB tetravalent conditional agonist

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Program

Therapeutic Area

Target(s)/Format

STAGE OF DEVELOPMENT

Preclinical

Phase 1

Phase 2

Phase 3

INBRX-101*

Orphan/Respiratory

Neutrophil Elastase
AAT-Fusion Protein

INBRX-109**

Oncology

DR5
Tetravalent Agonist

INBRX-106***

Oncology

OX40
Hexavalent Agonist

INBRX-105***

Oncology

PD-L1 x 4-1BB
Tetravalent Conditional Agonist

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* Commercialization and development rights outside of the United States and Canada, subject to an option agreement with Chiesi Farmaceutici S.p.A., or Chiesi

** Third party partnership with Chinese biotechnology company, Transcenta Holding, Ltd. (formerly Hangzhou Just Biotherapeutics Co., Ltd.), or Transcenta, currently in place for development and commercialization in China, Hong Kong, Macau and/or Taiwan.

*** Third party partnership with Chinese biotechnology company, Elpiscience Biopharmaceuticals, Inc, or Elpiscience, currently in place for development and commercialization in China, Hong Kong, Macau and/or Taiwan.

INBRX-101 is an optimized, recombinant alpha-1 antitrypsin, or AAT, augmentation therapy candidate for AATD. In March 2022, the U.S. Food and Drug Administration, or FDA, granted orphan-drug designation for INBRX-101 for the treatment of AATD. In May 2022, we announced topline results from the INBRX-101 Phase 1 clinical trial. The data revealed the potential to achieve normal AAT levels with monthly dosing and showed the treatment was well tolerated with no drug-related severe or serious adverse events at doses up to and including 120 mg/kg in single and multi-dose administered intravenously. We have submitted our briefing book to the FDA for the end-of-Phase 1 meeting planned to occur later in 2022.

Our most advanced therapeutic candidate, INBRX-109, is a tetravalent death receptor 5, or DR5, agonist currently being evaluated in patients diagnosed with difficult-to-treat cancers, such as chondrosarcoma, mesothelioma, colorectal cancer, Ewing sarcoma and pancreatic adenocarcinoma. We have ongoing Phase 1 cohorts with INBRX-109 in combination with standard chemotherapies in several indications. In June 2021, we initiated a potentially registration-enabling Phase 2 trial for the treatment of unresectable or metastatic conventional chondrosarcoma for which the FDA granted orphan-drug designation in November 2021. We plan to announce additional cohort data from the isocitrate dehydrogenase, or IDH, mutant population later this year at the annual conference hosted by the Connective Tissue Oncology Society’s, or CTOS.

INBRX-106 is a hexavalent OX40 agonist, currently being investigated as a single agent and in combination with Keytruda, a PD-1 blocking checkpoint inhibitor, in patients with locally advanced or metastatic solid tumors. In January 2022, we announced initial Phase 1 dose escalation results for INBRX-106 in combination with Keytruda, which was observed to be well tolerated with predominantly mild or moderate immune-related toxicities noted.

INBRX-105 is a conditional 4-1BB agonist that is currently being investigated as a single agent and in combination with Keytruda in patients with locally advanced or metastatic solid tumors. In June 2022, we announced Phase 1 dosed escalation results for INBRX-105 in combination with Keytruda. These results showed INBRX-105 was reasonably well-tolerated and we observed durable responses in checkpoint-naïve and relapsed refractory patients.

We anticipate additional data releases from INBRX-105 and INBRX-106 during the second or third quarter of 2023.

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Liquidity, Capital Resources and Financial Condition

Sources of Liquidity

In August 2020, we completed our initial public offering, or IPO, of 8,050,000 shares of our common stock at a price to the public of $17.00 per share, which included the exercise in full by the underwriters of their option to purchase 1,050,000 additional shares of our common stock. Our aggregate net proceeds from the offering were $125.9 million, net of underwriting discounts, commissions and offering costs.

~~Other sources~~Sources of capital raised to fund our operations have been comprised of the sale of equity securities, payments received from commercial partners for licensing rights to our therapeutic candidates under development and grants,

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borrowings under loan and security agreements, ~~or the 2020 Loan Agreement with Oxford Finance LLC, or Oxford, including $10.0 million of gross proceeds borrowed in July 2020,~~ and proceeds from the sale and issuance of convertible promissory ~~notes in May 2019~~notes.

The sale of equity securities includes proceeds under our initial public offering, or IPO, from which our aggregate net proceeds from the offering were $125.9 million, net of underwriting discounts, commissions and April 2020, or the 2019 Note and the 2020 Notes, respectively. In November 2020 and June 2021, we amended the 2020 Loan Agreement which provided for two additional tranches of term loans, including $20.0 million of grossoffering costs, as well as proceeds ~~received in November 2020, and an additional $40.0 million of gross proceeds in June 2021.~~

~~In September 2021, we entered into an~~under our Open Market Sale Agreement, or the Sales Agreement, with Jefferies LLC, or the Sales ~~Agent, under~~Agent. Under the Sales Agreement, which we entered into in September 2021, we may, from time to time, sell shares of common stock ~~having~~through the Sales Agent with an aggregate offering price of up to $200.0 ~~million through the Sales Agent.~~million. Sales of our common stock made pursuant to the Sales Agreement, if any, will be made under our $400.0 million Shelf Registration on Form S-3ASR, which became automatically effective upon filing on September 3, 2021. ~~As of September 30,~~During the year ended December 31, 2021, ~~there have been no sales of common stock~~we sold 921,042 shares pursuant to ~~either~~ the Sales Agreement for net proceeds of $40.2 million, after deducting commissions. During the six months ended June 30, 2022, we did not issue any shares under the Sales Agreement.

Our borrowings under the loan and security agreement, or the ~~Shelf Registration.~~Amended 2020 Loan Agreement, with Oxford Finance LLC, or Oxford, include $170.0 million in gross proceeds received in six tranches between July 2020 and June 2022. We have one future $30.0 million tranche available under the Amended 2020 Loan Agreement which we may draw upon the initiation of a registrational clinical trial of INBRX-101 on or before June 30, 2023.

Future Funding Requirements

Since our inception, we have devoted substantially all of our efforts to therapeutic drug discovery and development, conducting preclinical studies and clinical trials, enabling manufacturing activities in support of our therapeutic candidates, hiring to support our research and development activities and financial reporting capabilities, establishing our intellectual property portfolio, and raising capital to support and expand these activities. Cash used to fund operating expenses is impacted by the timing of when we pay these expenses, as reflected in the change in our outstanding accounts payable and accrued expenses. Our net losses may fluctuate significantly from quarter-to-quarter and year-to-year, depending on the timing of our clinical trials and our expenditures on other research and development activities.

Our net loss for the ~~nine~~six months ended ~~September~~June 30, 2022 and June 30, 2021 ~~and 2020~~ was ~~$60.6~~$69.0 million and ~~$58.5~~$40.0 million, respectively. As of ~~September~~June 30, ~~2021,~~2022, we had an accumulated deficit of ~~$206.0~~$296.1 million and cash and cash equivalents of ~~$112.7~~$176.4 million. Based upon our current operating plans, we believe that our existing cash and cash equivalents will be sufficient to fund our operations for at least the next 12 months from the date these condensed consolidated financial statements are issued. Our forecast of the period of time through which our financial resources will be adequate to support our operations is a forward-looking statement that involves risks and uncertainties, and actual results could vary materially. We have based this estimate on assumptions that may prove to be wrong, and we could deplete our capital resources sooner than we expect.

The process of conducting preclinical studies and testing product candidates in clinical trials is costly, and the timing of progress and expenses in these studies and trials is uncertain. We expect to continue to incur net losses for the foreseeable future, and we expect our research and development expenses to increase as we continue our development of, and seek ~~regulatory~~marketing approvals for, our therapeutic candidates (especially as we move more candidates from preclinical to clinical development as well as study candidates in later stages of clinical development), and begin to commercialize any approved products, if ever. If we elect to proceed with the commercialization of any of our product candidates, we would incur significant commercialization expenses related to product sales, marketing, manufacturing and distribution. We also expect our general and administrative expenses and losses to increase as we hire additional personnel and incur increased accounting, audit, legal, regulatory, and compliance costs, and as we incur increased costs from investor and public relations expenses associated with operating as a public company.

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Until such time, if ever, we can generate substantial product revenue, we expect to finance our cash needs through equity offerings, debt financings or other capital sources, including strategic licensing and ~~collaboration~~collaborations, disposition transactions, strategic transactions, or other similar ~~agreements.~~arrangements and transactions. However, there can be no assurance as to the availability or terms upon which such finances or capital might be available in the future. If we are unable to secure adequate additional funding, we will need to reevaluate our operating plan and may be forced to make reductions in spending, extend payment terms with suppliers, liquidate assets where possible, delay, scale back or eliminate some or all of our development programs, or relinquish rights to our intellectual property on less favorable terms than we would otherwise choose. These actions could materially impact our business, results of operations, financial condition, and prospects.

Our future liquidity and capital funding requirements will depend on numerous factors, including:

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•the outcome, costs and timing of preclinical studies and clinical trials for our current or future therapeutic candidates;

•whether and when we are able to obtain ~~regulatory~~marketing approval to market any of our therapeutic ~~candidates;~~candidates and the outcome of meetings with applicable regulatory agencies, including the FDA;

•our ability to successfully commercialize any therapeutic candidates that receive ~~regulatory~~marketing approval;

•the emergence and effect of competing or complementary therapeutics or therapeutic candidates;

•our ability to maintain, expand and defend the scope of our intellectual property portfolio, including the amount and timing of any payments we may be required to make, or that we may receive, in connection with the licensing, filing, prosecution, defense and enforcement of any patents or other intellectual property rights;

•our ability to retain our current employees and the need and ability to hire additional management and scientific and medical personnel;

•the terms and timing of any strategic licensing, collaboration or other similar agreement that we have established or may establish;

•our ability to repay, refinance or restructure our indebtedness when payment is due, including in the event such indebtedness is accelerated;

•the valuation of our capital stock; and

•the continuing or future effects of the COVID-19 pandemic and ~~related uncertainties~~geopolitical events such as the ongoing conflict in Ukraine on capital and financial markets.

We do not own or operate manufacturing facilities for the production of any of our therapeutic candidates, nor do we have plans to develop our own manufacturing operations in the foreseeable future. We currently rely on a limited number of third-party contract manufacturers for all of our required raw materials, antibodies, and other biologics for our preclinical research, clinical trials, and if and when applicable, commercial product, and employ internal resources to manage our manufacturing relationships with these third parties.

Commitments

Our material cash requirements from known contractual and other obligations primarily relate to our lease obligations, debt, and services provided by our third party contract research organizations, or CROs, and contract development and manufacturing organizations, or CDMOs.

We have two leases for our laboratory and office space, which expire in 2025, with an option to extend the leases for an additional five years. As of June 30, 2022, we have future minimum rental obligations under these leases of $6.7 million, of which $2.2 million and $4.5 million are current and non-current, respectively. For more information regarding these lease agreements, refer to Note 8 to the condensed consolidated financial statements.

Under the Amended 2020 Loan Agreement, we are required to make interest-only payments through February 2025, with all principal payments and final fee payments beginning in March 2025 and continuing through the maturity date, or January 2027. As of June 30, 2022, we have an obligation of $237.6 million of long-term debt, including interest and final fee payments, of which $14.1 million and $223.5 million are current and non-current, respectively. For more information regarding the Amended 2020 Loan Agreement, refer to Note 3 to the condensed consolidated financial statements.

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We enter into contracts in the normal course of business with CROs related to our ongoing preclinical studies and clinical trials with CDMOs for clinical supplies and manufacturing scale-up activities. These contracts are generally cancellable, with notice, at our option. We have recorded accrued expenses of approximately $8.9 million in our condensed consolidated balance sheets for expenditures incurred by CROs and CDMOs as of June 30, 2022.

While these contracts are generally cancellable, some may contain specific activities that involve one or more non-cancellable commitments, including minimum purchase commitments, binding annual forecasts, and capital equipment investments. Additionally, depending on the timing and reasoning of the exit, certain termination penalties may apply and can range from the cost of work performed to date up to twelve months of future committed manufacturing costs. As of June 30, 2022, the non-cancellable portion of these contracts total in aggregate, excluding amounts recorded in accounts payable and accrued expenses as of this date, approximately $2.3 million.

License and Collaboration Agreements

Celgene Agreement

On July 1, 2013, we entered into a license agreement with Celgene Corporation, a ~~Bristol-Myers~~Bristol Myers Squibb Company, or Celgene, as amended on November 23, 2018, or the Celgene Agreement, pursuant to which we granted Celgene an exclusive, global license for the development, manufacture and commercialization of our proprietary CD47 binding domain, or the Celgene Licensed Intellectual Property. Per the terms of the Celgene Agreement, Celgene is operationally and financially responsible for the development, manufacturing and commercialization activities of Celgene Licensed Intellectual Property and any additional related antibodies covered by the Celgene Agreement.

As payment for the license granted in the Celgene Agreement, we may be eligible to receive development and regulatory milestones of an aggregate of $934.1 million, assuming the achievement of all potential milestones in the Celgene Agreement, as well as percentage tiered royalties based on future worldwide sales, with rates ranging between the high single-digits and low teens, subject to potential reduction when and if comparable third party products attain certain levels of competitive market share (on a country-by-country basis) and, subject to certain limitations, payments to third parties for third-party intellectual property rights. We are obligated to pay 2% of future amounts received under the Celgene Agreement to advisors who assisted us with the negotiations and other matters in connection with the Celgene Agreement.

~~WuXi Agreement~~

On August 28, 2018, we entered into the Amended and Restated Master Services Agreement, as amended by Amendment No. 1 to Amended and Restated Master Services Agreement dated December 11, 2019, or the WuXi Agreement, with WuXi Biologics (Hong Kong) Limited, or WuXi, pursuant to which we agreed, for three years and subject to certain conditions, to exclusively use WuXi to manufacture our therapeutic candidates for which we plan to first initiate clinical studies outside of China. Under the WuXi Agreement, WuXi and certain of its affiliates will provide biologics development and manufacturing services on a project-by-project basis. In August 2021, the

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~~exclusivity provisions of the Wuxi Agreement expired, and the Company may use manufacturers other than Wuxi to manufacture its therapeutic candidates.~~

Per the terms of the WuXi Agreement, we will own all intellectual property created, developed or reduced to practice by WuXi in the course of providing services to us; provided that, certain intellectual property created or developed by WuXi may be owned exclusively by WuXi if this intellectual property (i) relates to generally applicable experimental methods, (ii) relates to generally applicable manufacturing processes, developed solely at WuXi’s expense, or (iii) is derivative of WuXi’s pre-existing intellectual property.

Per the terms of the WuXi Agreement, fees will be mutually agreed upon on a project-by-project basis. We also may be eligible to receive discounts in the low- to mid-single digits for certain projects and services per the terms of the WuXi Agreement.

2seventy bio Agreements

On December 20, 2018, we entered into an exclusive license agreement with bluebird bio, Inc., or bluebird, to research, develop and commercialize ~~chimeric antigen receptor, or~~ CAR T-cell therapies using our proprietary sdAb platform. In November 2021, bluebird assigned ~~the agreement, which we refer to as~~ the 2018 2seventy Agreement to its affiliate 2seventy bio, Inc., or 2seventy, in connection with an internal restructuring and subsequent spin-out of 2seventy. Under the terms of this license agreement, we ~~will provide~~provided 2seventy the exclusive worldwide rights to develop, manufacture and commercialize certain cell therapy products containing sdAbs directed to various cancer targets. In January 2019, we received a $7.0 million payment and pursuant to the license agreement, we are entitled to receive developmental milestone payments of up to an aggregate of $51.5 million per therapeutic, as well as percentage tiered royalties on future product sales with rates in the mid-single digits. In August 2021, we received a $2.0 million milestone payment under this agreement.

On June 9, 2020, we entered into an option and license agreement with bluebird, pursuant to which we granted to bluebird exclusive worldwide rights to develop binders and cell therapy products containing sdAbs directed to specified targets, consisting of two initial programs and up to an additional 8 programs. Inhibrx retains all rights to the specific sdAbs outside of the cell therapy field. This agreement, which we refer to as the 2020 2seventy Agreement, which was also assigned to 2seventy in November 2021 in connection with bluebird’s internal restructuring and subsequent spin-out of 2seventy. WeIn June 2020, we received a non-refundable upfront option fee of $0.2 million in connection with each of the two initial programs, or $0.4 million in aggregate, and we are entitled to an upfront option fee for each additional program. In June 2022, 2seventy selected a third program and paid an additional $0.2 million as a non-refundable upfront option fee in exchange for a development license. We also granted ~~an option~~options in which 2seventy may acquire an exclusive license with respect to all binders and cell therapy products developed under the 2020 2seventy Agreement, which entitles us to additional fees upon exercise of ~~the option.~~an option for each program. We are also entitled to receive certain developmental milestone payments of up to an aggregate of $51.5 million per therapeutic, as well as percentage tiered royalties on future product sales with rates in the mid-single-digits.

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$0.1 million. In August 2021, pursuant to the option exercise terms in the agreement, bluebird exercised its option to exclusively license one of the initial programs in exchange for an option exercise fee of $2.1 million, the payment of which was received in October 2021.

Chiesi

In May 2019, we entered into the Chiesi Option Agreement. Under this agreement, we granted to Chiesi an exclusive option to obtain an exclusive license to develop and commercialize INBRX-101 outside of the United States and Canada. Additionally, the Chiesi Option Agreement provides Chiesi with a right of negotiation for INBRX-101 development and commercialization rights in the United States and Canada in the event we engage in discussions with any third parties for such rights during the term of the Chiesi Option Agreement or, as applicable, the term of a definitive exclusive license agreement between Chiesi and the Company. Under the terms of the Chiesi Option Agreement, we received a one-time, non-refundable option initiation payment of $10.0 million in August 2019. Pursuant to the Chiesi Option Agreement, we are performing research and development services for Chiesi during the option period, which will continue (unless the Chiesi Option Agreement is terminated earlier by the Chiesi or the Company) until 60 days following the last to occur of (i) the Company’s delivery to Chiesi of the trial phase data for the first Phase I Clinical Trial, (ii) the Company’s delivery to Chiesi of the finalized minutes from the definitive FDA scientific advice meeting conducted following completion of such Phase I Clinical Trial, and (iii) the Company’s delivery to Chiesi of the finalized minutes from the definitive parallel EMA-HTA scientific advice meeting conducted following completion of such Phase I Clinical Trial.

If Chiesi chooses to exercise its option under the Chiesi Option Agreement, we will receive a one-time, non-refundable fee of $12.5 million upon the effective date of the definitive agreement granting Chiesi the exclusive license. If the option is exercised, under the license agreement, we may be entitled to receive specified milestone payments of up to $122.5 million, as well as royalties on future product sales.

Other Collaboration Agreements

In addition to these contracts, we have entered into strategic collaborations with other third parties, ~~such as Chiesi,~~including Phylaxis BioScience, LLC, or Phylaxis, Transcenta, and Elpiscience. For more information regarding these agreements, refer to Note 76 to the condensed consolidated financial statements.

Components of Results of Operations

Revenue

To date, all of our revenue has been derived from licenses with collaboration partners and grant awards. We have not ~~yet~~ generated any revenue from the commercial sale of approved therapeutic products, and we expect our

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revenue for the next several years will be derived primarily from payments under our current and any future grant awards and agreements with our collaboration partners.

Operating Expenses

Research and Development

To date, our research and development expenses have related primarily to research activities, including our discovery efforts, and preclinical and clinical development and the manufacturing of our therapeutic candidates. Research and development expenses are recognized as incurred and payments made prior to the receipt of goods or services to be used in research and development are capitalized until the goods or services are received. We do not track our internal research and development expenses on a program-by-program basis as they primarily relate to personnel, early research and consumable costs, which are deployed across multiple projects under development.

Research and development expenses consist primarily of:

•External expenses, consisting of:

◦expenses incurred in connection with the preclinical development of our programs;

◦clinical trials of our therapeutic candidates, including under agreements with third parties, such as consultants and ~~contract research organizations, or~~ CROs;

◦expenses associated with manufacturing our contract development and manufacturing therapeutic candidates including under agreements with ~~contract development~~CDMOs;

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◦expenses associated with regulatory requirements, including fees and ~~manufacturing organizations,~~other expenses related to our Scientific Advisory Board, or ~~CDMOs;~~SAB; and

◦other external expenses, such as laboratory services related to our discovery and development programs and other shared services, and

•Internal expenses, consisting of:

◦salaries, benefits and other related costs, including stock-based compensation, for personnel engaged in research and development functions;

◦facilities, depreciation and other expenses, which include direct and allocated expenses for depreciation and amortization, rent and maintenance of facilities; and

◦other internal expenses, such as laboratory supplies and other shared research and development costs.

We expect that research and development expense will continue to increase over the next several years as we continue development of our therapeutic candidates currently in clinical stage development, support our preclinical programs, and continue to discover new therapeutic candidates, as well as increase our headcount. In particular, clinical development of our therapeutic candidates, as opposed to preclinical development, generally has higher development costs, primarily due to the increased size and duration of later-stage clinical trials. Moreover, the costs associated with our CDMOs to manufacture our therapeutic candidates and future commercial products is also much more costly as compared to early stage preclinical development. We cannot determine with certainty the timing of initiation, the duration or the completion costs of current or future preclinical studies and clinical trials of our therapeutic candidates due to the inherently unpredictable nature of preclinical and clinical development. Preclinical and clinical development timelines, the probability of success and development costs can differ materially from expectations. We anticipate that we will make determinations as to which therapeutic candidates to pursue and how much funding to direct to each therapeutic candidate on an ongoing basis in response to the results of ongoing and future preclinical studies and clinical trials, regulatory developments and our ongoing assessments as to each therapeutic candidate’s commercial potential. We will need substantial additional capital in the future to support these efforts. In addition, we cannot forecast which therapeutic candidates may be subject to future collaborations, when such arrangements will be secured, if at all, and to what degree such arrangements would affect our development plans and capital requirements.

Our clinical development costs may vary significantly based on factors such as:

•per patient trial costs;

•the number of trials required for approval;

•the number of sites included in the trials;

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•the countries in which the trials are ~~conducted~~conducted;

•the length of time required to enroll eligible patients;

•the number of patients that participate in the trials;

•the number of doses that patients receive;

•the drop-out or discontinuation rates of patients;

•potential additional safety monitoring requested by regulatory agencies;

•the duration of patient participation in the trials and follow-up;

•the cost and timing of manufacturing of our therapeutic candidates;

•the phase and development of our therapeutic candidates;

•the efficacy and safety profile of our therapeutic candidates; and

•uncertainties related to the COVID-19 pandemic.

General and Administrative

G&A expenses consist primarily of:

•salaries, benefits and other related costs, including stock-based compensation, for personnel engaged in G&A functions;

•expenses incurred in connection with accounting and audit services, legal services, ~~commercial and business development~~ and investor relations, as well as consulting ~~expense~~expenses under agreements with third parties, such as consultants and contractors;

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•expenses incurred in connection with commercial and business development activity; and

•facilities, depreciation and other expenses, which include direct and allocated expenses for depreciation and amortization, rent and maintenance of facilities, insurance and supplies.

We expect our G&A expenses will continue to increase over the next several years as we continue to increase our headcount and incur increased accounting, audit, legal, regulatory, commercialization, business development, and compliance costs as well as investor and public relations expenses associated with operating as a public company.

Other Income (Expense)

~~Other income (expense)~~Interest expense. Interest expense consists primarily of our interest ~~expense~~ on our ~~debt from~~loans with Oxford, ~~and, prior to conversion,~~offset in part by our interest expense related to the amortization of the debt discount related to the 2019 Note and the 2020 Notes. Other income (expense) also consists of gains or losses on the change in fair value of derivative liabilities and gains or losses on the change in fair value of warrant liabilities.income.

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Results of Operations

Comparison of the Three Months Ended ~~September~~June 30, ~~2021~~2022 and ~~2020~~June 30, 2021

The following table summarizes our condensed consolidated results of operations for each of the periods indicated (in thousands, except percentages):


		THREE MONTHS ENDED SEPTEMBER 30,				CHANGE					THREE MONTHS ENDED JUNE 30,				CHANGE
		2021		2020		($)		(%)			2022		2021		($)		(%)

Revenue:	Revenue:									Revenue:
License fee revenue	License fee revenue	$	2,508	$	5,826	$	(3,318)	(57)	%	License fee revenue	$	711	$	918	$	(207)	(23)	%
Grant revenue	Grant revenue	24		75		(51)		(68)	%	Grant revenue	—		36		(36)		(100)	%
Total revenue	Total revenue	2,532		5,901		(3,369)		(57)	%	Total revenue	711		954		(243)		(25)	%
Operating expense:	Operating expense:									Operating expense:
Research and development	Research and development	18,485		19,837		(1,352)		(7)	%	Research and development	29,906		17,902		12,004		67	%
General and administrative	General and administrative	2,848		1,622		1,226		76	%	General and administrative	5,402		2,853		2,549		89	%
Total operating expense	Total operating expense	21,333		21,459		(126)		(1)	%	Total operating expense	35,308		20,755		14,553		70	%
Loss from operations	Loss from operations	(18,801)		(15,558)		(3,243)		21	%	Loss from operations	(34,597)		(19,801)		(14,796)		75	%
Other expense
Other income (expense)										Other income (expense)
Interest expense, net	Interest expense, net	(1,778)		(4,428)		2,650		(60)	%	Interest expense, net	(3,148)		(914)		(2,234)		244	%
Other income, net	Other income, net	(1)		—		(1)		100	%	Other income, net	17		5		12		240	%
Change in fair value of warrant liabilities		—		(24)		24		(100)	%

Total other expense	Total other expense	(1,779)		(4,452)		2,673		(60)	%	Total other expense	(3,131)		(909)		(2,222)		244	%
Provision for income taxes	Provision for income taxes	—		—		—		—	%	Provision for income taxes	4		—		4		100	%
Loss on equity method investment		$	—	$	487	$	(487)	(100)	%

Net loss	Net loss	$	(20,580)	$	(20,497)	$	(83)	—	%	Net loss	$	(37,732)	$	(20,710)	$	(17,022)	82	%

License Fee Revenue

License fee revenue decreased by ~~$3.3~~$0.2 million to ~~$2.5~~$0.7 million during the three months ended ~~September~~June 30, ~~2021~~2022 from ~~$5.8~~$0.9 million during the three months ended ~~September~~June 30, ~~2020.~~2021. During the three months ended ~~September~~June 30, ~~2021, we recognized $2.0 million upon the achievement of a milestone under our license agreement with 2seventy. In addition,~~2022, approximately ~~$0.5~~$0.4 million of license fee revenue recognized was related to our agreements with Phylaxis while approximately $48,000 of license fee revenue recognized was related to our effort to satisfy the performance obligation relative to the total expense estimated to be incurred during the option period under our option agreement with Chiesi. During the three months ended September 30, 2020, $2.0 million of license fee revenue earned was related to our option agreement with Chiesi. Additionally, we achieved a milestone under our agreement with Elpiscience and recognized $2.0 million of revenue related to this agreement. We also recognized $0.8 million of revenue under our agreements with Phylaxis, and $1.1 million related to other license revenue from non-affiliates during the three months ended September 30, 2020.

~~Grant Revenue~~

Grant revenue during the three months ended September 30, 2021 consisted of revenue earned under a grant with the Department of Defense of $24,000. Grant revenue during the three months ended September 30, 2020 consisted of revenue earned under a prior grant with the Department of Defense of $75,000.

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~~Research and Development Expense~~

~~The following table sets forth the primary external and internal research and development expenses (in thousands, except percentages):~~

THREE MONTHS ENDED
SEPTEMBER 30, CHANGE
2021 2020 ($) (%)
External expenses:
Clinical trials $ 6,048 $ 2,299 $ 3,749 163 %
Preclinical studies 1,528 1,201 327 27 %
Contract manufacturing 794 9,779 (8,985) (92) %
Other external research and development 857 432 425 98 %
Internal expenses:
Personnel 6,781 3,981 2,800 70 %
Equipment, depreciation, and facility 1,401 1,250 151 12 %
Other internal research and development 1,076 895 181 20 %
Total research and development expenses $ 18,485 $ 19,837 $ (1,352) (7) %

Research and development expenses decreased by $1.3 million to $18.5 million during the three months ended September 30, 2021 from $19.8 million during the three months ended September 30, 2020. The overall decrease was primarily due to the following factors:

•~~clinical trial expense increased by $3.7 million, which was primarily attributable to increased CRO costs from the progression of our Phase 1 trials and the initiation of our Phase 2 trial;~~

•~~preclinical expense increased by $0.3 million, which was primarily attributable to additional preclinical studies;~~

•contract manufacturing expense decreased by $9.0 million, which was primarily attributable to the timing of work performed and raw materials purchased by our CDMO partners for the formulation and manufacturing of certain of our therapeutic candidates;

•~~personnel-related expense increased by $2.8 million, which was attributable to an increase in our headcount and the issuance of additional stock options; and~~

•~~facility and equipment-related expense increased by $0.2 million, which was attributable to an increase in depreciable equipment.~~

~~G&A Expense~~

G&A expenses increased by $1.2 million to $2.8 million during the three months ended September 30, 2021 from $1.6 million during the three months ended September 30, 2020. During the three months ended September 30, 2021, personnel expenses increased $0.7 million as compared to the same period in the prior year, primarily related to an increase in headcount and additional stock option grants to employees. We also incurred an increase of $0.3 million during the three months ended September 30, 2021 in legal fees related to patents as a result of the Company’s expanding intellectual property portfolio.

~~Other Expense~~

~~Interest expense, net.~~ Interest expense, net, decreased by $2.6 million to $1.8 million during the three months ended September 30, 2021 from $4.4 million during the three months ended September 30, 2020. During the three months ended September 30, 2021, we recorded $1.8 million of interest related to interest paid and the amortization of debt discounts related to the 2020 Loan Agreement. During the three months ended September 30, 2020, we incurred interest expense of $2.0 million related to the amortization of the 2019 Note and the 2020 Notes through their conversion date. Upon the IPO and the notes conversion, we accelerated amortization of the debt discounts for an

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additional $2.2 million of expense. Additionally, during the three months ended September 30, 2020, we recorded $0.3 million of interest related to interest paid and the amortization of debt discounts related to the 2020 Loan Agreement with Oxford.

~~Change in fair value of warrant liabilities.~~ During the three months ended September 30, 2021, we recorded no gain or loss related to the change in fair value of warrant liabilities since they no longer existed and were reclassified into equity prior to the beginning of the period. During the three months ended September 30, 2020, we recognized a loss on fair value of warrant liabilities of approximately $24,000 upon the remeasurement and reclassification of the warrants into equity following our IPO.

~~Comparison of the Nine Months Ended September 30, 2021 and 2020~~

~~The following table summarizes our condensed consolidated results of operations for each of the periods indicated (in thousands, except percentages):~~

NINE MONTHS ENDED
SEPTEMBER 30, CHANGE
2021 2020 ($) (%)
Revenue:
License fee revenue $ 4,289 $ 10,032 $ (5,743) (57) %
Grant revenue 86 80 6 8 %
Total revenue 4,375 10,112 (5,737) (57) %
Operating expense:
Research and development 52,825 55,827 (3,002) (5) %
General and administrative 8,710 4,621 4,089 88 %
Total operating expense 61,535 60,448 1,087 2 %
Loss from operations (57,160) (50,336) (6,824) 14 %
Other expense
Interest expense, net (3,437) (10,284) 6,847 (67) %
Other income, net 20 5 15 300 %
Change in fair value of warrant liabilities — (24) 24 (100) %
Change in fair value of derivative liabilities — 2,651 (2,651) (100) %
Total other expense (3,417) (7,652) 4,235 (55) %
Provision for income taxes 2 — 2 100 %
Loss on equity method investment — 487 (487) (100) %
Net loss $ (60,579) $ (58,475) $ (2,104) 4 %

~~License Fee Revenue~~

License fee revenue decreased by $5.7 million to $4.3 million during the nine months ended September 30, 2021 from $10.0 million during the nine months ended September 30, 2020. During the nine months ended September 30, 2021, we recognized $2.0 million upon the achievement of a milestone under our license agreement with 2seventy. In addition, approximately $1.8 million of license fee revenue recognized was related to our agreements with Phylaxis, while approximately $0.4$0.1 million of license fee revenue recognized was related to our effort to satisfy the performance obligation relative to the total expense estimated to be incurred during the option period under our option agreement with Chiesi. Additionally, during the three months ended June 30, 2022, we earned $0.2 million under our option and license agreement with 2seventy in which we granted them an exclusive option and development license upon initiation of a third program. During the ~~nine~~three months ended ~~September~~June 30, ~~2020, $5.8~~2021, approximately $0.1 million of license fee revenue ~~earned~~recognized was related to our option agreement with ~~Chiesi. Additionally, we achieved a milestone under our agreement with Elpiscience and recognized $2.0~~Chiesi, while approximately $0.7 million of license fee revenue recognized was related to ~~this agreement. Additionally, we recognized $0.8 million of revenue under~~ our agreements with ~~Phylaxis, $0.4~~Phylaxis. In addition, we recognized $0.1 million as an option extension fee under our ~~2020 Option~~option and ~~License Agreement~~license agreement with ~~2seventy, and another $1.1 million related to other license revenue from non-affiliates.~~bluebird.

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Grant Revenue

Grant revenue ~~of $86,000~~ during the ~~nine~~three months ended ~~September~~June 30, 2021 consisted of revenue earned under a grant with the Department of ~~Defense.~~ Defense of $36,000. During the three months ended June 30, 2022, there was no grant revenue following the completion of our grant with the Department of Defense in the first quarter of 2022.

Research and Development Expense

The following table sets forth the primary external and internal research and development expenses (in thousands, except percentages):


	THREE MONTHS ENDED JUNE 30,				CHANGE
	2022		2021		($)		(%)

External expenses:
Clinical trials	$	9,503	$	5,796	$	3,707	64	%
Contract manufacturing	7,059		315		6,744		2,141	%
Preclinical studies	989		1,131		(142)		(13)	%
Other external research and development	755		725		30		4	%
Internal expenses:
Personnel	8,821		7,202		1,619		22	%
Equipment, depreciation, and facility	1,520		1,357		163		12	%
Other internal research and development	1,259		1,376		(117)		(9)	%
Total research and development expenses	$	29,906	$	17,902	$	12,004	67	%

Research and development expenses increased by $12.0 million to $29.9 million during the three months ended June 30, 2022 from $17.9 million during the three months ended June 30, 2021. The overall increase was primarily due to the following factors:

•clinical trial expense increased by $3.7 million, primarily related to increases in Phase 1 trial expenses, including the purchase of Keytruda used in combination with INBRX-105 in our Phase 1 clinical trial, as well as continued expenses related to our INBRX-109 potentially registration-enabling Phase 2 trial for the treatment of unresectable or metastatic conventional chondrosarcoma, which was initiated in the second quarter of 2021;

•contract manufacturing expense increased by $6.7 million due to greater production run costs at our CDMO partners to support our clinical and preclinical therapeutic candidates, including larger yield batch sizes, drug substance batch manufacturing in preparation for a Phase 2 trial supply, and pilot batch production for a preclinical candidate; and

•personnel-related expense increased by $1.6 million, attributable to an increase in headcount including significant expansion of our clinical operations and technical operations teams, as well as the issuance of additional stock options and the expansion of the bonus eligibility pool during the current year.

G&A Expense

G&A expenses increased by $2.5 million to $5.4 million during the three months ended June 30, 2022 from $2.9 million during the three months ended June 30, 2021. The overall increase during the three months ended June 30, 2022 was primarily due to the following factors:

•personnel expenses increased by $1.7 million, primarily related to an increase in headcount primarily due to building out our commercial strategy team, additional stock option grants to employees, and the expansion of the bonus eligibility pool in the current year;

•pre-commercialization expenses increased by $0.4 million, primarily related to market research expenses in connection with INBRX-101 and INBRX-109; and

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•other G&A expense of $0.2 million of expenses related to our participation in a conference in which we presented data for INBRX-101.

Other income (expense)

Interest expense, net. Interest expense, net, increased by $2.2 million to $3.1 million during the three months ended June 30, 2022 from $0.9 million during the three months ended June 30, 2021. During the three months ended June 30, 2022, we recorded $3.2 million of interest related to interest paid and the amortization of debt discounts related to the Amended 2020 Loan Agreement, under which we had an outstanding principal balance of $170.0 million as of June 30, 2022. During the three months ended June 30, 2021, we incurred $1.0 million of interest related to interest paid and the amortization of debt discounts related to the Amended 2020 Loan with Oxford, under which we had an outstanding principal balance of $70.0 million as of June 30, 2021. Interest expense was offset in part by $0.1 million of interest income in each period.

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Comparison of the Six Months Ended June 30, 2022 and June 30, 2021

The following table summarizes our condensed consolidated results of operations for each of the periods indicated (in thousands, except percentages):


	SIX MONTHS ENDED JUNE 30,				CHANGE
	2022		2021		($)		(%)

Revenue:
License fee revenue	$	1,626	$	1,781	$	(155)	(9)	%
Grant revenue	14		62		(48)		(77)	%
Total revenue	1,640		1,843		(203)		(11)	%
Operating expense:
Research and development	54,801		34,340		20,461		60	%
General and administrative	10,453		5,862		4,591		78	%
Total operating expense	65,254		40,202		25,052		62	%
Loss from operations	(63,614)		(38,359)		(25,255)		66	%
Other income (expense)
Interest expense, net	(5,422)		(1,659)		(3,763)		227	%
Other income, net	54		21		33		157	%


Total other expense	(5,368)		(1,638)		(3,730)		228	%
Provision for income taxes	4		2		2		100	%

Net loss	$	(68,986)	$	(39,999)	$	(28,987)	72	%

License Fee Revenue

License fee revenue decreased by $0.2 million to $1.6 million during the six months ended June 30, 2022 from $1.8 million during the six months ended June 30, 2021. During the six months ended June 30, 2022, approximately $1.1 million of license fee revenue recognized was related to our agreements with Phylaxis while approximately $0.3 million of license fee revenue recognized was related to our effort to satisfy the performance obligation relative to the total expense estimated to be incurred during the option period under our option agreement with Chiesi. Additionally, during the six months ended June 30, 2022, we earned $0.2 million under our option and license agreement with 2seventy in which we granted an exclusive option and development license upon initiation of a third program. During the six months ended June 30, 2021, approximately $0.3 million of license fee revenue recognized was related to our effort to satisfy the performance obligation relative to the total expense estimated to be incurred during the option period under our option agreement with Chiesi, while approximately $1.4 million of license fee revenue recognized was related to our agreements with Phylaxis. In addition, we recognized $0.1 million as an option extension fee under our option and license agreement with 2seventy.

Grant Revenue

Grant revenue of ~~$80,000~~$14,000 and $62,000 during the ~~nine~~six months ended ~~September~~June 30, ~~2020~~2022 and June 30, 2021, respectively, consisted of revenue earned under a ~~prior~~ grant with the Department of Defense.

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Research and Development Expense

The following table sets forth the primary external and internal research and development expenses (in thousands, except percentages):


		NINE MONTHS ENDED SEPTEMBER 30,				CHANGE					SIX MONTHS ENDED JUNE 30,				CHANGE
		2021		2020		($)		(%)			2022		2021		($)		(%)

External expenses:	External expenses:									External expenses:
Clinical trials	Clinical trials	$	15,245	$	6,759	$	8,486	126	%	Clinical trials	$	14,510	$	9,197	$	5,313	58	%
Contract manufacturing										Contract manufacturing	13,952		2,917		11,035		378	%
Preclinical studies	Preclinical studies	3,272		2,447		825		34	%	Preclinical studies	1,981		1,744		237		14	%
Contract manufacturing		3,710		25,990		(22,280)		(86)	%
Other external research and development	Other external research and development	2,327		1,848		479		26	%	Other external research and development	1,841		1,470		371		25	%
Internal expenses:	Internal expenses:									Internal expenses:
Personnel	Personnel	20,720		12,227		8,493		69	%	Personnel	17,249		13,939		3,310		24	%
Equipment, depreciation, and facility	Equipment, depreciation, and facility	4,063		3,559		504		14	%	Equipment, depreciation, and facility	2,903		2,662		241		9	%
Other internal research and development	Other internal research and development	3,488		2,997		491		16	%	Other internal research and development	2,365		2,411		(46)		(2)	%
Total research and development expenses	Total research and development expenses	$	52,825	$	55,827	$	(3,002)	(5)	%	Total research and development expenses	$	54,801	$	34,340	$	20,461	60	%

Research and development expenses ~~decreased~~increased by ~~$3.0~~$20.5 million to ~~$52.8~~$54.8 million during the ~~nine~~six months ended ~~September~~June 30, ~~2021~~2022 from ~~$55.8~~$34.3 million during the ~~nine~~six months ended ~~September~~June 30, ~~2020.~~2021. The overall ~~decrease~~increase was primarily due to the following factors:

•clinical trial expense increased by ~~$8.5~~$5.3 million, ~~which was~~ primarily ~~attributable~~related to ~~increased CRO costs from~~increases in Phase 1 trial expenses, including the ~~progression~~purchase of Keytruda used in combination with INBRX-105 in our Phase 1 ~~trials and initiation of~~clinical trial, as well as continued expenses related to our INBRX-109 potentially registration-enabling Phase 2 ~~trial;~~

•~~preclinical expense increased by $0.8 million,~~trial for the treatment of unresectable or metastatic conventional chondrosarcoma, which was ~~primarily attributable to~~initiated in the ~~initiation~~second quarter of ~~additional preclinical studies;~~2021;

•contract manufacturing expense ~~decreased~~increased by ~~$22.3~~$11.0 million ~~which was primarily attributable~~due to ~~the timing of work performed and raw materials purchased by~~greater production run costs at our CDMO partners supporting our clinical and preclinical therapeutic candidates, including larger yield batch sizes, drug substance batch manufacturing in preparation for ~~the formulation~~a Phase 2 trial supply, pilot batch production for a preclinical candidate, and ~~manufacturing of certain of our therapeutic candidates;~~drug process development and manufacturing;

•personnel-related expense increased by ~~$8.5~~$3.3 million, which was attributable to an increase in our headcount including significant expansion of our clinical operations and technical operations teams, the issuance of additional stock ~~options;~~options, and the expansion of the bonus eligibility pool in the current year; and

•facility and equipment-related expense increased by ~~$0.5~~$0.2 million, which was attributable to an increase in depreciable equipment.

G&A Expense

G&A expenses increased by ~~$4.1~~$4.6 million to ~~$8.7~~$10.5 million during the ~~nine~~six months ended ~~September~~June 30, ~~2021~~2022 from ~~$4.6~~$5.9 million during the ~~nine~~six months ended ~~September~~June 30, ~~2020. During~~2021. The overall increase during the ~~nine~~six months ended ~~September~~June 30, ~~2021,~~ 2022, was primarily due to the following factors:

•personnel expenses increased ~~$2.4~~by $3.1 million, ~~as compared to the same period in the prior year, primarily~~ related to an increase in headcount ~~and~~primarily due to building out our commercial strategy team, additional stock option grants to ~~employees. We also incurred an increase~~employees, and the expansion of ~~$0.7~~the bonus eligibility pool in the current year;

•pre-commercialization expenses increased by $0.9 million, ~~during the nine months ended September 30, 2021 in legal fees~~primarily related to ~~patents as a result of the Company’s expanding intellectual property portfolio~~$0.8 million in market research expenses related to INBRX-101 and ~~an increase of $0.2~~INBRX-109 and $0.1 million ~~of other legal fees during the nine months ended September 30, 2021. Additionally, the Company incurred an increase~~ in other ~~costs of approximately $0.6 million during the nine months ended September 30, 2021 associated with~~consulting expenses ~~of operating as a public company following~~related to our ~~IPO in August 2020.~~commercial strategy efforts;

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•accounting fees increased by $0.3 million due to additional services required following the establishment of our ATM facility, as well as other consultation fees; and

•other G&A expense of $0.2 million related to our participation in a conference in which we presented data for INBRX-101.

Other Expense

Interest expense, net. Interest expense, net, ~~decreased~~increased by ~~$6.9~~$3.7 million to ~~$3.4~~$5.4 million during the ~~nine~~six months ended ~~September~~June 30, ~~2021~~2022 from ~~$10.3~~$1.7 million during the ~~nine~~six months ended ~~September~~June 30, ~~2020.~~2021. During the ~~nine~~six months ended ~~September~~June 30, ~~2021,~~2022, we recorded ~~$3.6~~$5.5 million of interest related to interest paid and the amortization of debt discounts related to the Amended 2020 Loan ~~Agreement.~~Agreement, under which we had an outstanding principal balance of $170.0 million as of June 30, 2022. Interest expense was offset in part by $0.1 million of interest ~~income.~~income during the six months ended June 30, 2022. During the ~~nine~~six months ended ~~September~~June 30, 2020, we incurred interest expense of $7.8 million related to the 2019 Note and the 2020 Notes prior to conversion into equity. Upon the IPO and the conversion of the notes, we recorded accelerated amortization of $2.2 million. During the nine months ended September 30, 2020,2021, we recorded interest expense of ~~$0.3~~$1.7 million of interest related to ~~our~~interest paid and the amortization of debt discounts related to the Amended 2020 Loan Agreement, ~~with Oxford and $44,000 related to our prior 2015 Loan Agreement with Oxford, both~~under which we had an outstanding principal balance of ~~which consisted~~$70.0 million as of ~~cash payments~~June 30, 2021.

Table of ~~interest and amortization of debt discounts.~~Contents

~~Change in fair value of warrant liabilities.~~ During the nine months ended September 30, 2021, we recorded no gain or loss related to the change in fair value of warrant liabilities since they no longer existed and were reclassified into equity prior to the beginning of the period. During the nine months ended September 30, 2020, we recognized a loss on fair value of warrant liabilities of approximately $24,000 upon the remeasurement and reclassification of the warrants into equity following our IPO.

~~Change in fair value of derivative liabilities.~~ During the nine months ended September 30, 2021, we recorded no gain or loss related to the change in fair value of derivative liabilities since they were already extinguished at the beginning of the period. During the nine months ended September 30, 2020, we recognized a gain of approximately $2.7 million related to the change in fair value of derivative liabilities upon the revaluation of the derivative to zero during the period.

Cash Flow Summary

The following table sets forth a summary of the net cash flow activity for each of the periods indicated (in thousands):


		NINE MONTHS ENDED SEPTEMBER 30,					SIX MONTHS ENDED JUNE 30,
		2021		2020			2022		2021

Net cash used in operating activities	Net cash used in operating activities	$	(57,703)	$	(32,579)	Net cash used in operating activities	$	(53,863)	$	(44,028)
Net cash used in investing activities	Net cash used in investing activities	(542)		(752)		Net cash used in investing activities	(439)		(373)
Net cash provided by financing activities	Net cash provided by financing activities	42,285		149,460		Net cash provided by financing activities	99,386		41,465
Net increase (decrease) in cash and cash equivalents	Net increase (decrease) in cash and cash equivalents	$	(15,960)	$	116,129	Net increase (decrease) in cash and cash equivalents	$	45,084	$	(2,936)

Operating Activities

Net cash used in operating activities was ~~$57.7~~$53.9 million during the ~~nine~~six months ended ~~September~~June 30, ~~2021~~2022 and consisted primarily of a net loss of ~~$60.6~~$69.0 million, adjusted for non-cash items including accretion on our debt discount and the non-cash portion of interest expense related to our debt of ~~$0.8~~$1.2 million, stock-based compensation expense of ~~$10.9~~$10.4 million, depreciation and amortization of ~~$0.9~~$0.6 million, and non-cash lease expense of ~~$1.1~~$0.8 million. Changes in operating assets and liabilities also contributed to the cash used in operating activities, primarily related to ~~increases~~decreases in prepaid expenses and other current assets of ~~$2.6 million and decreases in accounts payable of $1.2~~$2.0 million and accrued expenses and other current liabilities of ~~$5.1~~$2.9 million due to the timing of clinical activity and contract manufacturing work performed by our CDMO partners. These were offset by increases in other non-current assets of $1.3 million relating to deposits paid to one of our CRO partners. Additionally, deferred revenue decreased by ~~$0.9~~$1.4 million upon the recognition of revenue under our option and license agreements and the operating lease liability decreased by ~~$1.1~~$0.8 million.

Net cash used in operating activities was ~~$32.6~~$44.0 million during the ~~nine~~six months ended ~~September~~June 30, ~~2020~~2021 and consisted primarily of a net loss of ~~$58.5~~$40.0 million, adjusted for non-cash items including accretion on our debt discount and the non-cash portion of interest expense related to our debt of ~~$10.0~~$0.4 million, stock-based compensation expense of ~~$3.7~~$7.4 million, depreciation and amortization of ~~$0.8~~$0.6 million, and non-cash lease expense of ~~$1.0 million, the change in fair value of derivative liabilities of $2.7 million, and loss on equity method investment of $0.5~~$0.7 million. Changes in operating assets and liabilities also contributed to the cash used in operating activities, primarily related

~~Table~~ to an increase in prepaid expenses and other current assets of ~~Contents~~

~~to increases~~$2.1 million and a decrease in accounts payable of ~~$11.6~~$3.6 million and to accrued expenses and other current liabilities of ~~$6.2~~$6.4 million due to ~~an overall higher volume~~the timing of clinical activity and contract manufacturing work performed by our CDMO ~~partners, offset in part by a decrease in~~partners. Additionally, deferred revenue ~~of $4.1~~decreased by $0.4 million and ~~a decrease in~~ the operating lease liability ~~of $1.0~~decreased by $0.7 million.

Investing Activities

Net cash used in investing activities was ~~$0.5 million and $0.8~~$0.4 million during each of the ~~nine~~six months ended ~~September~~June 30, ~~2021~~2022 and ~~2020, respectively,~~June 30, 2021, and was related to capital purchases, including laboratory ~~equipment, and the expansion of our facility in La Jolla, California.~~equipment.

Financing Activities

Net cash provided by financing activities was ~~$42.3~~$99.4 million during the ~~nine~~six months ended ~~September~~June 30, 2022 and consisted primarily of approximately $98.9 million of proceeds from Oxford under the Amended 2020 Loan Agreement upon draw of the Term D Loan in February 2022 and the Term E and Term F Loans in June 2022. Additionally, we received approximately $0.6 million of proceeds upon the exercise of stock options.

Net cash provided by financing activities was $41.5 million during the six months ended June 30, 2021 and consisted primarily of approximately $40.0 million of gross proceeds from Oxford under the Amended 2020 Loan Agreement upon draw of the Term C Loan. Additionally, we received approximately ~~$2.4~~$1.5 million of proceeds received upon the exercise of stock options. ~~These were offset by the payment of approximately $0.1 million in deferred offering costs related to our Shelf Registration during the nine months ended September 30, 2021.~~

Net cash provided by financing activities was $149.5 million during the nine months ended September 30, 2020 and consisted primarily of the gross proceeds $136.9 million from our IPO during August 2020, which was partially offset by the payment of offering costs of $10.6 million. Additionally, the Company received proceeds of $15.0 million from the sale and issuance of the 2020 Notes, $10.0 million in proceeds from the issuance of the 2020 Loan Agreement with Oxford, and $1.9 million in borrowings from the Paycheck Protection Program under the Coronavirus Aid, Relief, and Economic Security Act, or PPP Loan. These proceeds were offset in part by repayments of $3.6 million on our 2015 Loan Agreement with Oxford, which consisted of the remaining principal payments and the final payment under that agreement.

~~Off-Balance Sheet Arrangements~~

~~We did not have during the periods presented, and we do not currently have, any off-balance sheet arrangements, as defined in the rules and regulations of the SEC.~~

Critical Accounting Estimates and Policies

Our management’s discussion and analysis of our financial condition and results of operations is based on our condensed consolidated financial statements, which have been prepared in accordance with accounting principles

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generally accepted in the United States of America, or GAAP. The preparation of financial statements requires us to make estimates and judgements that affect the reported amounts of assets, liabilities, revenues, costs and expenses and related disclosures. We base our estimates on historical experience and on various other assumptions that we believe to be reasonable under the circumstances. Changes in estimates are reflected in reported results for the period in which they become known. Actual results could differ significantly from the estimates made by our management.

There have been no material changes to our critical accounting policies and estimates from those disclosed in our financial statements and the related notes and other financial information included in our Annual Report on Form 10-K for the year ended December 31, ~~2020.~~2021.

~~JOBS Act Accounting Election~~

We are an “emerging growth company,” as defined in Jumpstart Our Business Startups Act of 2012, as amended, or the JOBS Act. Under the JOBS Act, emerging growth companies can delay adopting new or revised accounting standards issued subsequent to the enactment of the JOBS Act until such time as those standards apply to private companies. We have irrevocably elected not to take advantage of this extended transition period and, as a result, will comply with new or revised accounting standards on the relevant dates on which adoption of such standards is required for non-emerging growth companies.

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Recent Accounting Pronouncements

See Note 1 to our condensed consolidated financial statements included elsewhere in this Quarterly Report for a discussion of recent accounting pronouncements and their effect, if any, on us.

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Item 3. Quantitative and Qualitative Disclosures about Market Risks.

Interest Rate Risk

Our cash and cash equivalents consist of cash held in readily available checking and money market accounts. We are ~~a smaller reporting company as defined~~exposed to market risk related to fluctuations in interest rates and market prices. Our primary exposure to market risk is interest rate sensitivity, which is affected by ~~Rule 12b-2~~changes in the general level of United States interest rates. However, due to the short-term nature of the ~~Securities~~instruments in our portfolio, a sudden change in market interest rates would not be expected to have a material impact on our financial condition or results of operations.

Effects of Inflation

Inflation generally affects us by increasing our cost of labor and research and development contract costs. We do not believe inflation has had a material effect on our results of operations during the periods presented.

Foreign Currency Exchange ~~Act of 1934, as amended, or~~Risk

We are exposed to market risk related to changes in foreign currency exchange rates. We contract with vendors that are located outside the ~~Exchange Act,~~United States, and certain invoices are denominated in foreign currencies. We are subject to fluctuations in foreign currency rates in connection with these arrangements. To date, we have not ~~required to provide the information required under this item.~~experienced any material effects from foreign currency fluctuations.

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Item 4. Controls and Procedures.

Evaluation of Disclosure Controls and Procedures

We maintain disclosure controls and procedures that are designed to ensure that information required to be disclosed in our reports filed pursuant to the Exchange Act of 1934, as amended, or the Exchange Act, is recorded, processed, summarized, and reported within the time periods specified in the SEC’s rules and forms, and that such information is accumulated and communicated to our management, including our principal executive officer and principal financial and accounting officer, as appropriate, to allow timely decisions regarding required disclosure.

Our management, with the participation and supervision of our Chief Executive Officer and our Chief Financial Officer, evaluated the effectiveness of our disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act) as of the end of the period covered by this Quarterly Report. Based on that evaluation, our Chief Executive Officer and our Chief Financial Officer have concluded that, as of the end of the period covered by this Quarterly Report, our disclosure controls and procedures were designed and operating effectively at the reasonable assurance level.

Changes in Internal Control over Financial Reporting

There were no changes in our internal control over financial reporting that occurred during the quarter ended ~~September~~June 30, ~~2021~~2022 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

Inherent Limitations on Effectiveness of Controls

Our management, including our Chief Executive Officer and our Chief Financial Officer, does not expect that our disclosure controls or our internal control over financial reporting will prevent or detect all error and all fraud. A control system, no matter how well designed and operated, can provide only reasonable and not absolute assurance of achieving the desired control objectives. In reaching a reasonable level of assurance, management necessarily was required to apply its judgment in evaluating the benefits of possible controls and procedures relative to their costs. Controls can also be circumvented by the individual acts of some persons, by collusion of two or more people, or by management override of the controls. In addition, the design of any system of controls is based in part upon certain assumptions about the likelihood of future events, and there can be no assurance that any design will succeed in achieving its stated goals under all potential future conditions. Over time, controls may become inadequate because of changes in conditions or deterioration in the degree of compliance with policies or procedures.

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Part II — Other Information

Item 1. Legal Proceedings.

We are not currently a party to any material legal proceedings. From time to time, we may become involved in legal proceedings arising in the ordinary course of our business. Regardless of outcome, litigation can have an adverse impact on us due to defense and settlement costs, diversion of management resources, negative publicity, reputational harm and other factors.

Item 1A. Risk Factors.

~~Except for the risk factor set forth below, there~~There have been no material changes to the risk factors set forth in Part I, Item 1A of our Annual Report on Form 10-K for the year ended December 31, ~~2020.~~

~~Our insurance may not provide adequate levels of coverage against claims which may adversely affect our financial condition.~~

~~We maintain insurance that we believe is adequate for businesses~~2021 and in Part II, Item 1A of our size and type. However, there are types of losses that we believe are not economically reasonable to insure or that cannot be insured against. For instance, we believe because directors and officers, or D&O, liability insurance has become cost prohibitive with high retentions providing minimal coverage, we recently chose not to renew our D&O policy.

~~It is possible that we may be subject to securities litigation in~~Quarterly Report on Form 10-Q for the future, including potential class action or stockholder derivative actions. Our indemnification agreements with our directors and certain officers, as well as Delaware General Corporation Law, may require us, among other things, to indemnify them against certain liabilities that may arise by reason of their status or service as directors or officers. Without D&O insurance, the amounts we would pay to defend any such litigation or indemnify our officers and directors should they be subject to legal action based on their service to us could have a material adverse effect on our financial condition, results of operations and liquidity.

three months ended March 31, 2022.

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Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.

(a) Recent Sales of Unregistered Securities

None.

(b) Use of Proceeds

On August 18, 2020, the SEC declared effective our registration statement on Form S-1 (File No. 333-240135), as amended, filed in connection with our IPO. Our IPO closed on August 21, 2020, and we issued and sold 8,050,000 shares of our common stock at a price to the public of $17.00 per share, which included the exercise in full of the underwriters’ option to purchase additional shares. We received gross proceeds from our IPO of $136.9 million, before deducting underwriting discounts, commissions and offering costs of $11.0 million, for net proceeds of approximately $125.9 million. No offering expenses were paid directly or indirectly to any of our directors or officers (or their associates) or persons owning ten percent or more of any class of our equity securities or to any other affiliates.

The joint book-running managing underwriters of the offering were Jefferies LLC, Evercore Group L.L.C. and Credit Suisse Securities (USA) LLC, with LifeSci Capital as Co-Manager.

Upon receipt, the net proceeds from our IPO were held in cash and cash equivalents, primarily bank deposits and money market funds. Through ~~September~~June 30, ~~2021,~~2022, we have used a portion of the net proceeds from our IPO for the research and development of our programs and for general corporate purposes. There has been no material change in the planned use of proceeds from our IPO from those disclosed in the Prospectus for our IPO filed pursuant to Rule 424(b)(4) under the Securities Act with the SEC on August 18, 2020.

For the quarter ended ~~September~~June 30, ~~2021,~~2022, we did not repurchase any equity securities.

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Item 3. Defaults Upon Senior Securities.

None.

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Item 4. Mine Safety Disclosures.

Not applicable.

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Item 5. Other Information.

~~Amendment and Restatement of Executive Officer Employment Agreements~~

~~The following information is being included in this Item 5 in lieu of filing such information on a Current Report on Form 8-K under Item 5.02. Compensatory Arrangements of Certain Officers.~~

On November 8, 2021, in connection with the regularly scheduled review of executive compensation, the compensation committee of our board of directors approved the amendment and restatement of the employment agreements of Mark Lappe, Klaus Wagner, M.D., Ph.D., Brendan Eckelman, Ph.D., and Kelly Deck. The amended and restated employment agreements, which will be effective as of January 1, 2022, reflect an increased annual salary and/or an increased target annual bonus opportunity for each named executive officer. All other terms remain the same. The amended and restated employment agreements attached to this Quarterly Report as Exhibits 10.2, 10.3, 10.4, and 10.5 will supersede and replace the current employment agreements previously filed with the Securities and Exchange Commission.None.

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Item 6. Exhibits.

(a) Exhibits.

~~EXHIBIT~~

~~NO.~~

Exhibit No.

~~DESCRIPTION OF EXHIBIT~~Description of Exhibit

~~FILED~~

~~HEREWITH~~

Filed Herewith

~~FORM~~Form

~~INCORPORATED BY REFERENCE FILE NO.~~Incorporated By Reference File No.

~~DATE FILED~~Date Filed

10.1

~~Open Market Sale Agreement℠ by~~Fifth Amendment to Loan and ~~between the Registrant and Jefferies LLC,~~Security Agreement, dated ~~September 3, 2021~~

~~S-3ASR~~

~~333-259313~~

~~9/03/2021~~

~~10.2 Δ~~

~~Second Amended and Restated Executive Employment Agreement, effective as of January 1,~~June 15, 2022, by and between the Company and ~~Mark Lappe~~Oxford Finance LLC

~~10.3 Δ~~

~~Second Amended and Restated Executive Employment Agreement, effective as of January 1, 2022, by and between the Company and Klaus Wagner, M.D., Ph.D.~~8-K

X001-39452

~~10.4 Δ~~

~~Second Amended and Restated Executive Employment Agreement, effective as of January 1,~~ 06/16/2022 ~~by and between the Company and Brendan Eckelman, Ph.D.~~

~~10.5 Δ~~

~~Amended and Restated Executive Employment Agreement, effective as of January 1, 2022, by and between the Company and Kelly Deck~~

31.1

Certification of Principal Executive Officer pursuant to Rule 13a-14(a) of the Securities Exchange Act, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

31.2

Certification of Principal Financial Officer pursuant to Rule 13a-14(a) of the Securities Exchange Act, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

32.1*

Certification of Chief Executive Officer pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

32.2*

Certification of Chief Financial Officer pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

101.INS

Inline XBRL Instance Document - the instance document does not appear in the Interactive Data File because XBRL tags are embedded within the Inline XBRL document

101.SCH

Inline XBRL Taxonomy Extension Schema Document

101.CAL

Inline XBRL Taxonomy Extension Calculation Linkbase Document

101.DEF

Inline XBRL Taxonomy Extension Definition Linkbase Document

101.LAB

Inline XBRL Taxonomy Extension Label Linkbase Document

101.PRE

Inline XBRL Taxonomy Extension Presentation Linkbase Document

104

Cover Page Interactive Data File - the cover page XBRL tags are embedded within the Inline XBRL document contained in Exhibit 101

* This certification is deemed not filed for purpose of section 18 of the Exchange Act or otherwise subject to the liability of that section, nor shall it be deemed incorporated by reference into any filing under the Securities Act or the Exchange Act.

~~Δ Management Compensation Plan or arrangement~~

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.


						INHIBRX, INC.

Date: ~~November 9, 2021~~August 8, 2022						/s/ Mark P. Lappe
						Mark P. Lappe
						Chief Executive Officer and Chairman
						(Principal Executive Officer)

Date: ~~November 9, 2021~~August 8, 2022						/s/ Kelly D. Deck
						Kelly D. Deck, C.P.A.
						Chief Financial Officer
						(Principal Financial and Accounting Officer)

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Supplemental disclosure of cash flow information
Cash paid for interest	$	2,001	$	172
Cash paid for income taxes	$	2	$	—
Supplemental schedule of non-cash investing and financing activities
Deferred offering costs included in accounts payable and accrued expenses	$	198	$	430
Payable for purchase of fixed assets	$	23	$	46
Conversion of preferred stock to common stock	$	—	$	59,507
Conversion of the 2019 Note and the 2020 Notes to common stock	$	—	$	53,394
Debt discount arising from convertible note beneficial conversion features and reversal of beneficial conversion features	$	—	$	4,783
Operating lease liabilities arising from obtaining right-of-use assets	$	—	$	1,752



Derivative liabilities arising from the issuance of the 2019 Note and the 2020 Notes	$	—	$	735

Non-cash equity method investment	$	—	$	487

Reclassification of warrant liabilities to equity	$	—	$	139

Warrant liabilities issued to lender in conjunction with 2020 Loan Agreement	$	—	$	115
Initial public offering costs included in accounts payable and accrued expenses	$	—	$	5