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TABLE OF CONTENTS

As filed with the Securities and Exchange Commission on May 25, 2017February 1, 2021

Registration No. 333-        


UNITED STATES

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549



FORM S-3

FORM S-3
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933



CANCER GENETICS, INC.

(Exact Namename of Registrantregistrant as Specifiedspecified in Its Charter)its charter)

Delaware
(State or Other Jurisdiction of
Incorporation or Organization)
 04-3462475

(State or other jurisdiction of

incorporation or organization)

(I.R.S. Employer

Identification Number)

Cancer Genetics, Inc.

201 Route 17 North, 2nd Floor

Rutherford, NJ 07070

(201) 528-9200

(Address, Including Zip Code,including zip code, and Telephone Number, Including Area Code,telephone number, including area code, of Registrant's Principalregistrant’s principal executive offices)

John A. Roberts

Chief Executive Offices)Officer



Cancer Genetics, Inc.

John A. Roberts
Chief Operating Officer
Cancer Genetics, Inc.
201 Route 17 North, 2nd Floor

Rutherford, NJ 07070
(201) 528-9200

(Name, Address, Including Zip Code, and Telephone Number, Including Area Code, of Agent for Service)



(201) 528-9200

(Name, address, including zip code, and telephone number, including area code, of agent for service)

CopyCopies of all communications, including communications sent to the agent for service, to:


Alan Wovsaniker, Esq.
Meredith Prithviraj, Esq.

Lowenstein Sandler LLP
65 Livingston Avenue

One Lowenstein Drive

Roseland, New Jersey 07068
Telephone:

Tel: (973) 597-2500



Approximate date of commencement of proposed sale to the public:
From time to time after this Registration Statement becomes effective.



If the only securities being registered on this formForm are being offered pursuant to dividend or interest reinvestment plans, please check the following box.    obox: [  ]

If any of the securities being registered on this formForm are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box.    ýbox: [X]

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. o[  ]

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. o[  ]

If this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following box. o[  ]

If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following box. o[  ]

 

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large“large accelerated filer," "accelerated” “accelerated filer," "smaller” “smaller reporting company"company” and "emerging“emerging growth company"company” in Rule 12b-2 of the Exchange Act.

Large accelerated filero[  ]Accelerated filer[  ]
 Accelerated
Non-accelerated filero[X]Smaller reporting company[X]
 Non-accelerated filer o
(Do not check if a smaller reporting company)
 Smaller reporting company ý

Emerging growth companyý

[  ]

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ý[  ]



CALCULATION OF REGISTRATION FEE

        
 
Title of each class of securities
to be registered(1)

 Amount to be
Registered(1)

 Proposed Maximum
Offering price per
unit

 Proposed Maximum
Aggregate offering
Price(2)(3)

 Amount of
registration fee(4)

 

Common stock, $0.0001 par value per share

  (5) (5) (5)
 

Preferred stock, $0.0001 par value per share

  (5) (5) (5)
 

Warrants

  (5) (5) (5)
 

Overallotment Purchase Rights

  (5) (5) (5)
 

Units

  (5) (5) (5)
 

Total

     $100,000,000 $11,590(6)

 

(1)
This registration statement covers the registration of such indeterminate number of shares of common stock, such indeterminate number of shares of preferred stock, such indeterminate number of warrants to purchase common stock or preferred stock, such indeterminate amount and number of overallotment purchase rights (including subscription rights), representing rights to purchase common stock, preferred stock and warrants registered under this registration statement and units consisting of any combination of such securities, as shall have an aggregate initial offering price not to exceed $100,000,000. This registration statement also covers an indeterminate amount of securities that may be issued in exchange for, or upon conversion or exercise of preferred stock, or warrants being registered hereunder or pursuant to the antidilution provisions of any such securities. Any securities registered hereunder may be sold separately or as units with other securities registered hereunder.

(2)
In United States dollars or the equivalent thereof in any other currency, currency unit or units, or composite currency or currencies.

(3)
The proposed maximum per unit and aggregate offering prices per class of security will be determined from time to time by the registrant in connection with the issuance by the registrant of the securities registered hereunder.

(4)
Estimated solely for purposes of determining the registration fee pursuant to Rule 457(o) under the Securities Act of 1933.

(5)
Not required to be included in accordance with General Instruction II.D. of Form S-3.

(6)
Pursuant to Rule 415(a)(6) under the Securities Act, the securities registered pursuant to the registration statement include $77,464,000 of unsold securities previously registered on the registrant's registration statement on Form S-3 filed on May 29, 2014 and declared effective on June 5, 2014 (File No. 333-196374) (the "Prior Registration Statement"). The Prior Registration Statement registered securities for a proposed maximum aggregate offering price of $100,000,000, of which $77,464,000 remain unsold. The associated filing fee of $8,978.08 for the securities remaining under the Prior Registration Statement is hereby used to offset the current registration fee due, resulting in an additional registration fee in the amount of $2,611.92 due in connection with the filing of this registration statement. Pursuant to Rule 415(a)(6), the offering of such securities registered under the Prior Registration Statement will be deemed terminated as of the date of effectiveness of this registration statement.

 

Title of Each Class of
Securities to be
Registered
 Amount to be Registered(1)  

Proposed Maximum
Offering

Price per Share (2)

  Proposed Maximum
Aggregate Offering
Price
  Amount of Registration
Fee (3)
 
Common Stock, $0.0001 par value per share (4)  5,682,765  $3.71  $21,083,059  $2,300.17 

(1)Pursuant to Rule 416 under the Securities Act of 1933, as amended (the “Securities Act”), the shares of common stock offered hereby also include an indeterminate number of additional shares of common stock as may from time to time become issuable by reason of stock splits, stock dividends, recapitalizations or other similar transactions.
(2)Estimated solely for the purpose of computing the amount of the registration fee pursuant to Rule 457(c) under the Securities Act based upon the average of the high and low prices for a share of the registrant’s common stock as reported on the Nasdaq Capital Market on January 27, 2021, which date is within five business days of the filing of this registration statement.
(3)Calculated in accordance with Rule 457(c) under the Securities Act.
(4)Represents the resale of (A)(i) 2,758,624 shares of common stock and (ii) 2,758,624 shares of common stock issuable upon the exercise of the common warrants, in each case issued in a private placement described herein, and (B) 165,517 shares of common stock issuable upon the exercise of the placement agent warrants issued in connection with the private placement described herein.

The registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically states that this registration statement shall thereafter become effective in accordance with SectionTHE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(a) of the Securities Act ofOF THE SECURITIES ACT OF 1933, or until the registration statement shall become effective on such date as the Securities and Exchange Commission, acting pursuant to said SectionAS AMENDED, OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME EFFECTIVE ON SUCH DATE AS THE SECURITIES AND EXCHANGE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(a), may determine.MAY DETERMINE.

 


The information in this prospectus is not complete and may be changed. WeThe selling stockholders named in this prospectus may not sell these securities until the registration statement filed with the Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities and it isthe selling stockholders named in this prospectus are not soliciting an offer to buy these securities in any state where the offer or sale is not permitted.

SUBJECT TO COMPLETION, DATED MAY 25, 2017FEBRUARY 1, 2021

PRELIMINARY PROSPECTUS

$100,000,000

LOGO

CANCER GENETICS, INC.

Common Stock
Preferred Stock
Warrants
Overallotment Purchase Rights
Units



 We

PROSPECTUS

Cancer Genetics, Inc.

5,682,765 Shares

Common Stock

The selling stockholders named in this prospectus may use this prospectus to offer and resell from time to time up to 5,682,765 shares of our common stock, par value $0.0001 per share (“Common Stock”), which are comprised of (i) 2,758,624 shares (the “Shares”) of our Common Stock issued in a private placement on February 1, 2021 (the “Private Placement”), pursuant to a certain Securities Purchase Agreement by and among us and certain institutional and accredited investors (the “Purchasers”), dated as of January 28, 2021 (the “Securities Purchase Agreement”), (ii) 2,758,624 shares of Common Stock (the “Common Warrant Shares”) issuable upon the exercise of the common warrants (the “Common Warrants”) issued in the Private Placement, pursuant to the Securities Purchase Agreement, and (iii) 165,517 shares of Common Stock (the “Placement Agent Warrant Shares”) issuable upon the exercise of the placement agent warrants (the “Placement Agent Warrants”) we issued to certain selling stockholders as the designees of H.C. Wainwright & Co., LLC (“Wainwright”) on February 1, 2021, as part of Wainwright’s compensation for serving as our exclusive placement agent in connection with the Private Placement.

We refer to the Common Warrants and the Placement Agent Warrants collectively as the “Warrants.”

The Shares and Common Warrants were issued to the Purchasers in reliance upon the exemption from the registration requirements in Section 4(a)(2) of the Securities Act of 1933, as amended (the “Securities Act”) and Regulation D (Rule 506) thereunder. Each Purchaser represented that it was an “accredited investor” (as defined by Rule 501 under the Securities Act). We are registering the offer and sell common stock, preferred stock, warrants, overallotment purchase rights and units, having an aggregate offering price of up to $100,000,000. We may offer and sell these securities separately or together in any combination. The preferred stock, warrants and overallotment purchase rights may be convertible into, or exercisable or exchangeable for, common or preferred stock or other securities of ours. The units may consist of any combinationresale of the securities listed above. We may offerShares and sell these securitiesthe Common Warrant Shares to or through underwriters, directlysatisfy a provision in a certain registration rights agreement, dated January 28, 2021 (the “Registration Rights Agreement”), pursuant to investors or through agents. which we agreed to register the resale of the Shares and the Common Warrant Shares.

In addition, the Placement Agent Warrants were issued to Wainwright’s designees in reliance upon the exemption from the registration requirements in Section 4(a)(2) of the Securities Act and Regulation D thereunder.

We will specify the termsnot receive any of the securities,proceeds from the sale of our Common Stock by the selling stockholders. However, we will receive proceeds from the exercise of the Warrants if the Warrants are exercised for cash. We intend to use those proceeds, if any, for general corporate purposes.

Any shares of Common Stock subject to resale hereunder will have been issued by us and acquired by the namesselling stockholders prior to any resale of any underwriters or agents and their respective compensation, in supplementssuch shares pursuant to this prospectus.

 

The selling stockholders named in this prospectus, or their donees, pledgees, transferees or other successors-in-interest, may offer or resell the shares from time to time through public or private transactions at prevailing market prices, at prices related to prevailing market prices or at privately negotiated prices. The selling stockholders will bear all commissions and discounts, if any, attributable to the sale of shares of Common Stock offered hereby, and all selling and other expenses incurred by the selling stockholders. We will bear all costs, expenses and fees in connection with the registration of the shares of Common Stock offered hereby. For additional information on the methods of sale that may be used by the selling stockholders, see “Plan of Distribution” beginning on page 9 of this prospectus.

Our common stockCommon Stock is listed on the on The NASDAQNasdaq Capital Market and traded under the symbol "CGIX." The“CGIX.” On January 29, 2021, the last reported salessale price of our common stockCommon Stock as reported on The NASDAQthe Nasdaq Capital Market on May 23, 2017 was $4.05$4.00 per share. We have no preferred stock, warrants, overallotment purchase rights or units listed on any market. Each prospectus supplement will indicate if the securities offered thereby will be listed on any securities exchange.

 

Investing in our securities involves risks. See "Risk Factors" ata high degree of risk. These risks are discussed in this prospectus under “Risk Factors” beginning on page 4 of3 and in the documents incorporated by reference into this prospectus.

 

Neither the Securities and Exchange Commission (the “SEC”) nor any state securities commission has approved or disapproved of these securities or passed upon the accuracyadequacy or adequacyaccuracy of this prospectus. Any representation to the contrary is a criminal offense.

 This prospectus may not be used to consummate sales of securities unless it is accompanied by a prospectus supplement.

The date of this prospectus is       , 2017.2021



TABLE OF CONTENTS

Page

ABOUT THIS PROSPECTUS

1 

ABOUT CANCER GENETICSTHIS PROSPECTUS

ii
 1 
PROSPECTUS SUMMARY

RISK FACTORS

1
 4 
RISK FACTORS

3
SPECIAL NOTE REGARDING FORWARD-LOOKING INFORMATIONSTATEMENTS

4
 4 

USE OF PROCEEDS

5
 4 
SELLING STOCKHOLDERS

DESCRIPTIONS OF THE SECURITIES WE MAY OFFER

6
 5 

DESCRIPTIONPLAN OF COMMON STOCKDISTRIBUTION

9
 5 
LEGAL MATTERS

DESCRIPTION OF PREFERRED STOCK

11
 7 
EXPERTS

DESCRIPTION OF WARRANTS

11
 9 

DESCRIPTION OF OVERALLOTMENT PURCHASE RIGHTS

10

DESCRIPTION OF UNITS

12

PLAN OF DISTRIBUTION

12

LEGAL MATTERS

14

EXPERTS

14

INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

14

WHERE YOU CAN FIND MORE INFORMATION

12
  
15INCORPORATION OF CERTAIN INFORMATION BY REFERENCE13

 

 No dealer, salesperson or other person has been authorized to give any information or to make any representations other than those contained or incorporated by reference in this prospectus or any accompanying prospectus supplement in connection with the offer made by this prospectus or any accompanying prospectus supplement and, if given or made, such information or representations must not be relied upon as having been authorized by Cancer Genetics, Inc. or any such person. Neither the delivery of this prospectus or any accompanying prospectus supplement nor any sale made hereunder and thereunder shall under any circumstances create an implication that there has been no change in the affairs of Cancer Genetics, Inc. since the date hereof. This prospectus or any accompanying prospectus supplement does not constitute an offer or solicitation by anyone in any state in which such offer or solicitation is not authorized or in which the person making such offer or solicitation is not qualified to do so or to anyone to whom it is unlawful to make such offer or solicitation.

i


Table of Contents


ABOUT THIS PROSPECTUS

 

This prospectus is part of a registration statement on Form S-3 that we filed with the Securities and Exchange Commission, or the SEC using a "shelf"“shelf” registration process. Under this shelf process, we may sell any combination of the securities describedThe selling stockholders named in this prospectus may resell, from time to time, in one or more offerings, up to a total dollar amountthe shares of $100,000,000. We have provided to you inCommon Stock offered by this prospectus. Information about the selling stockholders may change over time. When the selling stockholders sells shares of Common Stock under this prospectus, a general description of the securities we may offer. Each time we sell securities under this shelf registration process, we will, if necessary and required by law, provide a prospectus supplement that will contain specific information about the terms of thethat offering. WeAny prospectus supplement may also add to, update, modify or change in the prospectus supplement or any "free writing prospectus" we may authorize to be delivered to you any of thereplace information contained in this prospectus. ToIf a prospectus supplement is provided and the extent there is a conflict betweendescription of the information containedoffering in this prospectus and the prospectus supplement or any free writingvaries from the information in this prospectus, we may authorize to be delivered to you, you should rely on the information in the prospectus supplement or free writingsupplement. You should carefully read this prospectus asand the case may be, provided thataccompanying prospectus supplement, if any, statement in onealong with all of these documents is inconsistent with a statement in another document having a later date—for example, a documentthe information incorporated by reference herein and therein, before making an investment decision.

You should rely only on the information contained or incorporated by reference in this prospectus or any applicable prospectus supplement—supplement. We have not, and the statementselling stockholders have not, authorized any other person to provide you with different or additional information. If anyone provides you with different or additional information, you should not rely on it. This prospectus is not an offer to sell, nor are the selling stockholders seeking an offer to buy, the shares offered by this prospectus in any jurisdiction where the offer or sale is not permitted. No offers or sales of any of the shares of Common Stock are to be made in any jurisdiction in which such an offer or sale is not permitted. You should assume that the information contained in this prospectus or in any applicable prospectus supplement is accurate only as of the date on the front cover thereof or the date of the document havingincorporated by reference, regardless of the later date modifiestime of delivery of this prospectus or supersedes the earlier statement. This prospectus, together with theany applicable prospectus supplements andsupplement or any free writing prospectus we may authorize to be delivered to you, includes all material information relating to this offering.sales of the shares of Common Stock offered hereby or thereby.

 An investment in our securities involves certain risks that should be carefully considered by prospective investors. See "Risk Factors."

You should read thisthe entire prospectus and any prospectus supplement and any related issuer free writing prospectus, as well as additional information described under "Incorporation of Certain Documents by Reference" and "Where You Can Find More Information" on pages 14 and 15, respectively.


ABOUT CANCER GENETICS

Overview

        We are an emerging leader in the field of precision medicine, enabling individualized therapies in the field of oncology through our diagnostic products and services and molecular markers. We develop, commercialize and provide molecular- and biomarker-based tests and services that enable physicians to personalize the clinical management of each individual patient by providing genomic information to better diagnose, monitor and inform cancer treatment and that enable biotech and pharmaceutical companies engaged in oncology trials to better select candidate populations and reduce adverse drug reactions by providing information regarding genomic factors influencing subject responses to therapeutics. We have a comprehensive, disease-focused oncology testing portfolio. Our tests and techniques target a wide range of cancers, covering nine of the top ten cancers in prevalence in the United States, with additional unique capabilities offered by our FDA-cleared Tissue of Origin® test for identifying difficult to diagnose tumor types or poorly differentiated metastatic disease.

        Our vision is to become the oncology diagnostics partner for pharmaceutical and biotech companies and clinicians by participating in the entire care continuum from bench to bedside. We believe the oncology industry is undergoing a rapid evolution in its approach to diagnostic, prognostic and treatment outcomes (theranostic) testing, embracing precision medicine and individualized testing as a means to drive higher standards of patient treatment and disease management. Similarly, pharmaceutical and biotech companies are increasingly working with precision diagnostic and molecular technology providers such as CGI to provide molecular profiles on clinical trial participants. These profiles may help identify biomarker and genomic variations that may be responsible for differing responses to oncology therapies, thereby increasing the efficiency of trials while lowering costs. We believe tailored and combination therapies can revolutionize oncology care through molecular- and


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biomarker-based testing services, enabling physicians and researchers to target the factors that make each patient and disease unique.

        We believe the next wave in cancer management will bring together testing capabilities for germline, or inherited mutations, and somatic mutations that arise in tissues over the course of a lifetime. We have created a unique position in the industry by providing both targeted somatic analysis of tumor sample cells alongside germline analysis of an individual's non-cancerous cells' molecular profile as we attempt to continue achieving milestones in precision medicine.

        Cancer is genetically-driven and constitutes a diverse class of diseases with various causes, each characterized by uncontrollable cell growth. Many cancers are becoming increasingly understood at a molecular level and it is possible to attribute specific cancers to identifiable genetic changes in unhealthy cells. Cancer cells contain modified genetic material compared to normal human cells. Common genetic abnormalities correlated to cancer include gains or losses of genetic material on specific chromosomal regions (loci) or changes in specific genes (mutations) that ultimately result in detrimental cellular changes followed by cancerous or pre-cancerous conditions. Understanding the differences in these molecular changes helps clinicians to identify and stratify different forms of cancer in order to optimize patient treatment and patient management. Therefore, understanding and analysis of cancer at the molecular level is not only useful for diagnostic purposes, but we also believe it can play an important role in prognosis and disease management. We believe technology that can apply predictive information has the potential to dramatically improve treatment outcomes for patients living with cancer. Our molecular- and biomarker-based tests for cancer aim to remove subjectivity from the diagnostic phase, and add prognostic information, thus enabling personalized treatments based on cancer analysis at its most basic level.

        Our business is based on demand for molecular- and biomarker-based diagnostic services from three main sectors, including cancer centers and hospitals, biotechnology and pharmaceutical companies, and the research community. Clinicians and oncologists in cancer centers and hospitals seek testing since these methods often produce higher value and more accurate cancer diagnostic information than traditional analytical methods. Our proprietary and disease-focused tests aim to provide actionable information that can guide patient management decisions, potentially resulting in decreased costs for care providers and patients while streamlining therapy selection. Our services are also sought by biotechnology and pharmaceutical companies engaged in designing and running clinical trials to determine the value and efficacy of oncology treatments and therapeutics. We believe trial participants' likelihood of experiencing either favorable or adverse responses to the trial treatment may be influenced or dependent on genomic factors. Our testing services may increase trial efficiency, subject safety and trial success rates. Our services are also sought by researchers and research groups seeking to identify biomarkers and develop methods for diagnostic technologies and tests for disease. We aggressively pursue the strategy of trying to demonstrate increased value and efficacy with payors who are trying to contain costs and academic collaborators seeking to develop new insights and cures.

        Our market strategy is organized to align with the three aforementioned industry segments. We utilize relatively the same technologies across each of these businesses to deliver results-oriented information which we believe is or will become important to cancer treatment and patient management. Our tests address the limitations of traditional cancer diagnostic approaches, including reliance on human inspection of specimens and interpretation of clinical measurements, and inter-institutional variability. Our suite of clinical and biopharma services aim to remove subjectivity from diagnoses and additionally provide information that may influence treatment selection that cannot be obtained from anatomic pathology and staining techniques alone. We believe the level of personalized treatment required to optimize a patient's treatment regimen and to maximize clinical trial success rates may be significantly improved through the use of molecular- and biomarker-based cancer characterization.


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        The following table lists our market strategy by customer category:

Customer Category
Types of CustomersNature of Services
Clinical Services

Hospitals

Cancer Centers

Clinics

Clinical services provide information on diagnosis, prognosis and predicting treatment outcomes (theranosis) of cancers to guide patient management.

Biopharma Services

Pharmaceutical and Biotech companies performing clinical trials

Biopharma services provide companies with customized solutions for patient stratification and treatment selection through an extensive suite of molecular- and biomarker-based testing services, customized assay development and trial design consultation.

Discovery Services

Pharmaceutical and Biotech companies

Academic Institutions

Government-Sponsored Research Institutions

Discovery services provide the tools and testing methods for companies and researchers seeking to identify new molecular-based biomarkers for disease.

        In 2016, we generated approximately 57% of our revenue from Biopharma Services, approximately 39% from Clinical Services and approximately 4% from Discovery Services. In 2015, we generated approximately 64% of our revenue from Biopharma Services, approximately 31% from Clinical Services and approximately 5% from Discovery Services.

        We utilize relatively the same proprietary and nonproprietary molecular diagnostic tests and technologies across all of our service offerings to deliver results-oriented information important to cancer treatment and patient management. Our portfolio primarily includes comparative genomic hybridization (CGH) microarrays, gene expression tests, next generation sequencing (NGS) panels, and DNA fluorescentin situ hybridization (FISH) probes. We provide our testing services from our Clinical Laboratory Improvement Amendments ("CLIA")—certified and College of American Pathologists ("CAP")—accredited laboratories in Rutherford, NJ, Los Angeles, CA, and Raleigh, NC, as well as our NABL and GMP-certified laboratories in Hyderabad, India and Shanghai, China.


Cancer Genetics Corporate Information

        Our principal executive offices are located at 201 Route 17 North, 2nd Floor, Rutherford, New Jersey 07070, and our telephone number is (201) 528-9200. Our common stock is currently traded on The NASDAQ Capital Market under the symbol "CGIX." We maintain a corporate website atwww.cancer genetics.com. The contents of our website are notdocuments incorporated by reference into this prospectus and should not be considered to be a partor any prospectus supplement or any related issuer free writing prospectus, before making an investment decision. Neither the delivery of this prospectus or relied uponany prospectus supplement or any issuer free writing prospectus nor any sale made hereunder shall under any circumstances imply that the information contained or incorporated by reference herein or in connection herewith.any prospectus supplement or issuer free writing prospectus is correct as of any date subsequent to the date hereof or of such prospectus supplement or issuer free writing prospectus, as applicable. You should assume that the information appearing in this prospectus, any prospectus supplement or any document incorporated by reference is accurate only as of the date of the applicable documents, regardless of the time of delivery of this prospectus or any sale of securities. Our business, financial condition, results of operations and prospects may have changed since that date.

ii

PROSPECTUS SUMMARY

This summary provides an overview of selected information contained elsewhere or incorporated by reference in this prospectus and does not contain all of the information you should consider before investing in our securities. You should carefully read the prospectus, the information incorporated by reference and the registration statement of which this prospectus is a part in their entirety before investing in our securities, including the information discussed under “Risk Factors” in this prospectus and the documents incorporated by reference and our financial statements and related notes that are incorporated by reference in this prospectus. As used in this prospectus, unless the context otherwise indicates, the terms “we,” “our,” “us,” or “the Company” refer to Cancer Genetics, Inc., a Delaware corporation, and its subsidiaries taken as a whole.

Overview

Cancer Genetics, Inc. supports the efforts of the biotechnology and pharmaceutical industries to develop innovative new drug therapies. Following the Business Disposals (as defined below), the Company currently has an extensive set of anti-tumor referenced data based on predictive xenograft and syngeneic tumor models from the acquisition of vivoPharm, Pty Ltd. (“vivoPharm”) in 2017, to provide Discovery Services such as contract research services, focused primarily on unique specialized studies to guide drug discovery and development programs in the oncology and immuno-oncology fields. vivoPharm is a contract research organization (“CRO”) that specializes in planning and conducting unique, specialized studies to guide drug discovery and development programs with a concentration in oncology and immuno-oncology. These studies range from early compound selection to developing comprehensive sets of in vitro and in vivo data, as needed for FDA Investigational New Drug (“IND”) applications.

The Company offers preclinical services such as predictive tumor models, human orthotopic xenografts and syngeneic immuno-oncology relevant tumor models in its Hershey, PA facility, and is a leader in the field of immuno-oncology preclinical services in the United States. This service is supplemented with GLP toxicology and extended bioanalytical services in the Company’s Australian-based facilities in Clayton, Victoria, and Gilles Plains, South Australia.

Corporate Information

The Company was incorporated under the laws ofin the State of Delaware inon April 8, 1999. On July 16, 2014, wethe Company purchased substantially all of the assets of Gentris Corporation, ("Gentris"), a laboratory specializing in pharmacogenomics profiling for therapeutic development, companion diagnostics and clinical trials. On August 18, 2014 we entered into two agreements by which we acquired BioServe Biotechnologies (India) Pvt. Ltd. ("BioServe"), a premier genomics services provider serving both the research and clinical markets in India, and as a result of the acquisition, BioServe became a subsidiary of ours. On October 9, 2015, Cancer Geneticsthe Company acquired substantially all the assets and assumed certain liabilities of Response Genetics, Inc. ("Response Genetics"

On August 18, 2014 the Company acquired BioServe Biotechnologies (India) Pvt. Ltd. (“BioServe”) in connection with. On April 26, 2018, the Company sold BioServe to Reprocell, Inc.


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Response Genetics' filing of a chapter 11 petition for bankruptcy inOn August 15, 2017, the Delaware Bankruptcy Court for approximately $12.9 million, comprised of $7.5 million, in cash, and 788,584 sharesCompany purchased all of the Company's commonoutstanding stock of vivoPharm, with its principal place of business in Victoria, Australia.

On July 5, 2019, the Company entered into an asset purchase agreement with siParadigm, LLC, pursuant to which the Company sold to siParadigm certain assets associated with the common stock being valuedCompany’s clinical laboratory business and agreed to cease operating the Clinical Business (the “Clinical Business Disposal”). On July 15, 2019, the Company entered into commercial agreements with the Company’s senior lenders to divest all of the assets relating to the BioPharma Business (the “BioPharma Business Disposal” and, together with the Clinical Business Disposal, the “Business Disposals”), in satisfaction of all of the Company’s senior debt.

The Company’s principal executive offices are located at $5.4 million. Unless otherwise stated, all references to "us," "our," "Cancer Genetics," "we," the "Company" and similar designations refer to Cancer Genetics, Inc. and its wholly-owned subsidiaries.

        This prospectus201 Route 17 North, 2nd Floor, Rutherford, New Jersey 07070. The Company’s telephone number is (201) 528-9200 and the corporate website address is www.cancergenetics.com. The Company included the website address in this prospectus only as an inactive textual reference and does not intend it to be an active link to the Company website. The information on the website is not incorporated by reference include trademarks, service marksin this prospectus.

The Company’s most recent annual report on Form 10-K, quarterly reports on Form 10-Q, current reports on Form 8-K and trade names owned by usall amendments to those reports, as well as other documents the Company files with the U.S. Securities and Exchange Commission (“SEC”), such as the Company’s registration statement on Form S-4 (File No. 333-249513) filed on October 16, 2020 (the “Form S-4”), are available free of charge through the Investors section of the Company website as soon as reasonably practicable after such material is electronically filed with or other companies. All trademarks, service marks and trade names included or incorporated by reference into this prospectus arefurnished to the property of their respective owners.SEC. The public can obtain documents that the Company files with the SEC at www.sec.gov.

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RISK FACTORS
the offering

 

Common Stock offered by the selling stockholders

Up to 5,682,765 shares of Common Stock, which are comprised of (i) 2,758,624 shares of Common Stock, (ii) 2,758,624 shares of Common Stock issuable upon the exercise of the Common Warrants and (iii) 165,517 shares of Common Stock issuable upon the exercise of the Placement Agent Warrants.

Selling stockholders

All of the shares of Common Stock are being offered by the selling stockholders named herein. See “Selling Stockholders” on page 6 of this prospectus for more information on the selling stockholders.

Use of Proceeds

We will not receive any proceeds from the sale of the shares in this offering. However, we will receive proceeds from the exercise of the Warrants if the Warrants are exercised for cash. We intend to use those proceeds, if any, for general corporate purposes. See “Use of Proceeds” beginning on page 5 of this prospectus for additional information.

Registration Rights

Under the terms of the Registration Rights Agreement, we have agreed to file this registration statement with respect to the registration of the resale by the selling stockholders of the Shares and the Common Warrant Shares by February 2, 2021 at 9:30 a.m., New York Time. We have agreed to cause such registration statement to become effective under the Securities Act by the 60th day following the date of the Registration Rights Agreement (or by the 90th day following the date of the Registration Rights Agreement if there is a review of the registration statement by the SEC). In addition, we agreed that, upon the registration statement being declared effective, we will use our best efforts to maintain the effectiveness of the registration statement until the earlier of (i) the selling stockholders have sold all of the Shares and Common Warrant Shares or (ii) such shares may be resold by the selling stockholders pursuant to Rule 144 of the Securities Act, without the requirement for us to be in compliance with the current public information required under such rule and without volume or manner-of-sale restriction.

The selling stockholders do not have any registration rights in connection with the Placement Agent Warrants.

See “Selling Stockholders” on page 6 of this prospectus for additional information.

Plan of Distribution

The selling stockholders named in this prospectus, or their pledgees, donees, transferees, distributees, beneficiaries or other successors-in-interest, may offer or sell the shares of Common Stock from time to time through public or private transactions at prevailing market prices, at prices related to prevailing market prices or at privately negotiated prices. The selling stockholders may also resell the shares of Common Stock to or through underwriters, broker-dealers or agents, who may receive compensation in the form of discounts, concessions or commissions.

See “Plan of Distribution” beginning on page 9 of this prospectus for additional information on the methods of sale that may be used by the selling stockholders.

Risk Factors

Investing in our Common Stock involves a high degree of risk. You should carefully read and consider the information beginning on page 3 of this prospectus set forth under the heading “Risk Factors” and all other information set forth in this prospectus, and the documents incorporated herein and therein by reference before deciding to invest in our Common Stock.

Nasdaq Capital Market symbol“CGIX”

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RISK FACTORS

InvestingAn investment in our securities involves significantcertain risks. Before making an investment decision,investing in our securities, you should carefully consider the risks, uncertainties and other information we include or incorporate by reference in this prospectus and any prospectus supplement. In particular, you should consider the risk factorsassumptions discussed under the heading "Risk Factors"“Risk Factors” included in the Form S-4, our most recent Annual Report on Form 10-K, as may be revised or supplemented byand any updates in our subsequent Quarterly Reports on Form 10-Q or Current Reports on Form 8-K, eachtogether with all of which are on file with the SEC and areother information appearing in this prospectus or incorporated herein by reference into this prospectus and which may be amended, supplemented or superseded from time to time by other reports we file with the SEC in the future. The risks and uncertainties we haveso described are not the only onesrisks facing our company. Additional risks and uncertainties not currentlypresently known to us or that we currently deem immaterial may also impair our business operations. Any of these risks could materially and adversely affect our business, operations. Additional risk factors may be included in a prospectus supplement relating to a particular offering of securities. Our business, financial condition, or results of operations and cash flows and could be materially adversely affectedresult in a loss of all or part of your investment. In any case, the value of the securities offered by anymeans of these risks. The trading price of our securitiesthis prospectus could decline due to any of these risks, and you may lose all or part of your investment. This prospectus is qualified in its entirety by these risk factors.Please also read carefully the section below entitled “Special Note Regarding Forward-Looking Statements.”

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SPECIAL NOTE REGARDING FORWARD-LOOKING INFORMATION
STATEMENTS

 This prospectus, any prospectus supplement and the documents we incorporate by reference

Certain information set forth in this prospectus or incorporated by reference herein may contain forward-looking statements“forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended (the "Securities Act"), and Section 21E of the Securities Exchange Act, that are intended to be covered by the “safe harbor” created by those sections. Forward-looking statements, which are based on certain assumptions and describe our future plans, strategies and expectations, can generally be identified by the use of 1934,forward-looking terms such as amended (the "Exchange Act").“believe,” “expect,” “may,” “will,” “should,” “would,” “could,” “seek,” “intend,” “plan,” “goal,” “project,” “estimate,” “anticipate,” “strategy”, “future”, “likely” or other comparable terms and references to future periods. All statements other than statements of historical facts that we includeincluded in this prospectus any prospectus supplement, and the documents incorporated by reference regarding our strategies, prospects, financial condition, operations, costs, plans and objectives are forward-looking statements. Examples of forward-looking statements include, among others, statements we make regarding expectations for revenues, cash flows and financial performance, the anticipated results of our development efforts and the timing for receipt of required regulatory approvals and product launches.

Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results and financial condition may differ materially from those indicated in the documents we incorporateforward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Important factors that could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statements include, among others, the following:

●       the expected benefits of, and potential value, including synergies, created by, the proposed “Merger” transaction between the Company and StemoniX, Inc. (“StemoniX”) for the stockholders of CGI;

●       likelihood of the satisfaction of certain conditions to the completion of the Merger, and whether and when the Merger will be consummated;

●       CGI’s ability to control and correctly estimate its operating expenses and its expenses associated with the Merger;

●       the Company’s ability to adapt its business for future developments in light of the global outbreak of COVID-19, which continues to rapidly evolve;

●       the Company’s ability to achieve profitability by increasing sales of the Company’s preclinical CRO services focused on oncology and immuno-oncology;

●       the Company’s ability to raise additional capital to meet its liquidity needs;

●       the Company’s ability to execute on its marketing and sales strategy for its preclinical research services and gain acceptance of its services in the market;

●       the Company’s ability to keep pace with rapidly advancing market and scientific developments;

●       the Company’s ability to satisfy U.S. (including FDA) and international regulatory requirements with respect to its services;

●       the Company’s ability to maintain its present customer base and obtain new customers;

●       competition from preclinical CRO services companies, many of which are much larger than the Company in terms of employee base, revenues and overall number of customers and related market share;

●       the Company’s ability to maintain the Company’s clinical and research collaborations and enter into new collaboration agreements with highly regarded organizations in the field of oncology so that, among other things, the Company has access to thought leaders in advanced preclinical and translational science;

●       potential product liability or intellectual property infringement claims;

●       the Company’s dependency on third-party manufacturers to supply it with instruments and specialized supplies;

●       the Company’s ability to attract and retain a sufficient number of scientists, clinicians, sales personnel and other key personnel with extensive experience in oncology and immuno-oncology, who are in short supply;

●       the Company’s ability to obtain or maintain patents or other appropriate protection for the intellectual property in its proprietary tests and services;

●       the Company’s ability to effectively manage its international businesses in Australia and Europe, including the expansion of its customer base and volume of new contracts in these markets;

●       the Company’s dependency on the intellectual property licensed to the Company or possessed by third parties;

●       the Company’s ability to adequately support future growth; and

●       other risks and uncertainties discussed in the Company’s Form S-4 filed on October 16, 2020 and annual report on Form 10-K for the year ended December 31, 2019, as updated in our Form 10-Q for the quarter ended September 30, 2020 and other reports, as applicable, the Company files with the Securities and Exchange Commission, which are incorporated by reference in this prospectus may be deemed forward-looking statements for purposes of the Securities Act and the Exchange Act. We use the words "anticipate," "believe," "estimate," "expect," "intend," "may," "plan," "project," "would" and similar expressions to identifyaccompanying prospectus.

Any forward-looking statements, although not all forward-looking statements contain these identifying words. We cannot guarantee that we actually will achieve the plans, intentions or expectations disclosed in our forward-looking statements and, accordingly, you should not place undue reliance on our forward-looking statements. There are a number of important factors that could cause actual results or events to differ materially from the forward-looking statements that we make, including the factors included in the documents we incorporatestatement made by reference in this prospectus. You should read these factors and the other cautionary statements made in the documents we incorporate by reference as being applicable to all related forward-looking statements wherever they appearus in this prospectus any prospectus supplement,is based only on information currently available to us and any document incorporated by reference.speaks only as of the date on which it is made. We caution you that we do not undertake anyno obligation to publicly update any forward-looking statementsstatement, whether written or oral, that may be made by us.


USE OF PROCEEDS

        Unless otherwise provided in the applicable prospectus supplement, we intend to use the net proceeds from the sale of the securities under this prospectus for working capital and other general corporate purposes. We will set forth in the prospectus supplement our intended use for the net


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proceeds received from the sale of any securities. Pending the use of the net proceeds, we may use the net proceeds to invest in investment-grade, interest-bearing securities.


DESCRIPTIONS OF THE SECURITIES WE MAY OFFER

        The descriptions of the securities contained in this prospectus, together with the applicable prospectus supplements, summarize all the material terms and provisions of the various types of securities that we may offer. We will describe in the applicable prospectus supplement relating to any securities the particular terms of the securities offered by that prospectus supplement. If we indicate in the applicable prospectus supplement, the terms of the securities may differ from the terms we have summarized below. We will also include in the prospectus supplement information, where applicable, about material United States federal income tax considerations relating to the securities, and the securities exchange, if any, on which the securities will be listed.

        We may sell from time to time, in one or more offerings:

    common stock;

    preferred stock;

    warrants to purchase common stock or preferred stock;

    overallotment purchase rights to purchase shares of common stock, preferred stock or warrants; and

    units consisting of any combination of the securities listed above.

        In this prospectus, we refer to the common stock, preferred stock, warrants, overallotment purchase rights and units collectively as "securities." The total dollar amount of all securities that we may sell will not exceed $100,000,000.

        This prospectus may not be used to consummate a sale of securities unless it is accompanied by a prospectus supplement.


DESCRIPTION OF COMMON STOCK

        Our third amended and restated certificate of incorporation authorizes us to issue up to 100,000,000 shares of common stock, par value $0.0001 per share. As of March 31, 2017, there were approximately 19,756,000 shares of common stock outstanding. All outstanding shares of our common stock are fully paid and non-assessable.

        The holders of our common stock are entitled to the following rights:

Voting Rights

        Holders of our common stock are entitled to one vote per share in the election of directors and on all other matters on which stockholders are entitled or permitted to vote. Holders of our common stock are not entitled to cumulative voting rights.

Dividend Rights

        Subject to the terms of any outstanding series of preferred stock, the holders of our common stock are entitled to dividends in the amounts and at times as may be declared by the board of directors out of funds legally available therefor.


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Liquidation Rights

        Upon liquidation or dissolution, holders of our common stock are entitled to share ratably in all net assets available for distribution to stockholders after we have paid, or provided for payment of, all of our debts and liabilities, and after payment of any liquidation preferences to holders of our preferred stock.

Other Matters

        Holders of our common stock have no redemption, conversion or preemptive rights. There are no sinking fund provisions applicable to our common stock. The rights, preferences and privileges of the holders of our common stock are subject to the rights of the holders of shares of any series of preferred stock that we may issue in the future.

Anti-Takeover Provisions

        Our third amended and restated certificate of incorporation and bylaws contain some provisions that could make our acquisition by means of a tender or exchange offer, a proxy contest or otherwise more difficult. These provisions are summarized below.

        Potential Effects of Authorized but Unissued Shares of Common Stock and Preferred Stock.    We have shares of common stock and preferred stock available for future issuance without stockholder approval. We may utilize these additional shares for a variety of corporate purposes, including future public offerings to raise additional capital, to facilitate corporate acquisitions or paymentwhether as a dividend on the capital stock. The existenceresult of unissued and unreserved common stock and preferred stock may enable our board of directors to issue shares to persons friendly to current managementnew information, future developments or to issue preferred stock with terms that could render more difficult or discourage a third-party attempt to obtain control of us by means of a merger, tender offer, proxy contest or otherwise, thereby protecting the continuity of our management.

        Special Meetings.    Stockholders cannot call special meetings of our stockholders. Our bylaws provide that special meetings of our stockholders may, unless otherwise prescribed by law, be called by our chairman of the board (if any), our board of directors or our chief executive officer and shall be held at such place, on such date and at such time as shall be fixed by our board of directors or the person calling the meeting. Business transacted at any special meeting shall be limited to matters relating to the purpose or purposes stated in the notice of the meeting.

        Undesignated Preferred Stock.    The ability to authorize undesignated preferred stock makes it possible for our board of directors to issue preferred stock with voting or other rights or preferences that could impede the success of any attempt to acquire us. The ability to issue preferred stock may have the effect of deferring hostile takeovers or delaying changes in control or management of our company.

        Delaware Anti-Takeover Statute.otherwise. We are subject to the provisions of Section 203 of the Delaware General Corporation Law regulating corporate takeovers. In general, Section 203 prohibits a publicly held Delaware corporation from engaging in a business combination with an interested stockholder for a period of three years following the date the person became an interested stockholder unless:

    prior to the date of the transaction, the board of directors of the corporation approved either the business combination or the transaction which resulted in the stockholder becoming an interested stockholder;

    upon completion of the transaction that resulted in the stockholder becoming an interested stockholder, the stockholder owned at least 85% of the voting stock of the corporation outstanding at the time the transaction commenced, excluding for purposes of determining the

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      number of shares outstanding (1) shares owned by persons who are directors and also officers and (2) shares owned by employee stock plans in which employee participants do not have the right to determine confidentially whether shares held subject to the plan will be tendered in a tender or exchange offer; and

    on or subsequent to the date of the transaction, the business combination is approved by the board and authorized at an annual or special meeting of stockholders, and not by written consent, by the affirmative vote of at least 662/3% of the outstanding voting stock which is not owned by the interested stockholder.

        Generally, a business combination includes a merger, asset or stock sale, or other transaction resulting in a financial benefit to the interested stockholder. An interested stockholder is a person who, together with affiliates and associates, owns or, within three years prior to the determination of interested stockholder status, owned 15% or more of a corporation's outstanding voting securities. We expect the existence of this provision to have an anti-takeover effect with respect to transactions our board of directors does not approve in advance. We also anticipate that Section 203 may discourage attempted acquisitions that might result in a premium over the market price for the shares ofsubsequent events and developments will cause our common stock held by stockholders.

        The provisions of Delaware law, our third amended and restated certificate of incorporation and our bylaws could have the effect of discouraging others from attempting hostile takeovers and, as a consequence, they may also inhibit temporary fluctuations in the market price of our common stock that often result from actual or rumored hostile takeover attempts. These provisions may also have the effect of preventing changes in our management. It is possible that these provisions could make it more difficultviews to accomplish transactions that stockholders may otherwise deem to be in their best interests.

Transfer Agent

        The transfer agent and registrar for our common stock is Continental Stock Transfer & Trust Company. Its address is 17 Battery Place, New York, New York, 10004 and its telephone number is (212) 509-4000.

NASDAQ Listing

        Our common stock is traded on The NASDAQ Capital Market under the symbol "CGIX."


DESCRIPTION OF PREFERRED STOCK

        Our third amended and restated certificate of incorporation authorizes us to issue up to 9,764,000 shares of preferred stock, par value $0.0001 per share. At March 31, 2017, there were no shares of preferred stock outstanding.

Terms of the Preferred Stock That We May Offer and Sell to You

        We summarize below some of the provisions that will apply to the preferred stock that we may offer to you unless the applicable prospectus supplement provides otherwise. This summary may not contain all information that is important to you.change. You should read the prospectus supplement, which will contain additional information and which may update or change some of the information below. Prior to the issuance of a new series of preferred stock, we will further amend our third amended and restated certificate of incorporation designating the stock of that series and the terms of that series. We will file a copy of the certificate of designation that contains the terms of each new series of preferred stock with the SEC each time we issue a new series of preferred stock. Each certificate of designation will establish the number of shares included in a designated series and fix the designation, powers, privileges, preferences and rights of the shares of each series as well as any applicable qualifications, limitations or restrictions. You should refer to the applicable certificate of designation as well as our third amended and restated certificate of incorporation before deciding to buy shares of our preferred stock as described in the applicable prospectus supplement.


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        Our board of directors has the authority, without further action by the stockholders, to issue preferred stock in one or more series and to fix the number of shares, dividend rights, conversion rights, voting rights, redemption rights, liquidation preferences, sinking funds, and any other rights, preferences, privileges and restrictions applicable to each such series of preferred stock.

        The issuance of any preferred stock could adversely affect the rights of the holders of common stock and, therefore, reduce the value of the common stock. The ability of our board of directors to issue preferred stock could discourage, delay or prevent a takeover or other corporate action.

        The terms of any particular series of preferred stock will be described in the prospectus supplement relating to that particular series of preferred stock, including, where applicable:

    the designation, stated value and liquidation preference of such preferred stock;

    the number of shares within the series;

    the offering price;

    the dividend rate or rates (or method of calculation), the date or dates from which dividends shall accrue, and whether such dividends shall be cumulative or noncumulative and, if cumulative, the dates from which dividends shall commence to cumulate;

    any redemption or sinking fund provisions;

    the amount that shares of such series shall be entitled to receive in the event of our liquidation, dissolution or winding-up;

    the terms and conditions, if any, on which shares of such series shall be convertible or exchangeable for shares of our stock of any other class or classes, or other series of the same class;

    the voting rights, if any, of shares of such series; the status as to reissuance or sale of shares of such series redeemed, purchased or otherwise reacquired, or surrendered to us on conversion or exchange;

    the conditions and restrictions, if any, on the payment of dividends or on the making of other distributions on, or the purchase, redemption or other acquisition by us or any subsidiary, of the common stock or of any other class of our shares ranking junior to the shares of such series as to dividends or upon liquidation;

    the conditions and restrictions, if any, on the creation of indebtedness by us or by any subsidiary, or on the issuance of any additional stock ranking on a parity with or prior to the shares of such series as to dividends or upon liquidation; and

    any additional dividend, liquidation, redemption, sinking or retirement fund and other rights, preferences, privileges, limitations and restrictions of such preferred stock.

        The description of the terms of a particular series of preferred stock in the applicable prospectus supplement will not be complete. You should refer to the applicable amendment to our third amended and restated certificate of incorporation for complete information regarding a series of preferred stock.

        The preferred stock will, when issued against payment of the consideration payable therefor, be fully paid and nonassessable. Unless otherwise specified in the applicable prospectus supplement, each series of preferred stock will, upon issuance, rank senior to the common stock and on parity in all respects with each other outstanding series of preferred stock. The rights of the holders of our preferred stock will be subordinate to that of our general creditors.


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DESCRIPTION OF WARRANTS

        The following description, together with the additional information we may include in any applicable prospectus supplements, summarizes the material terms and provisions of the warrants that we may offer under this prospectus and the related warrant agreementsdocuments referenced herein or therein and warrant certificates. While the terms summarized below will apply generally to any warrants that we may offer, we will describe the particular terms of any series of warrants in more detail in the applicable prospectus supplement. If we indicate in the prospectus supplement, the terms of any warrants offered under that prospectus supplement may differ from the terms described below. Specific warrant agreements will contain additional important terms and provisions and will be incorporated by reference as an exhibit to the registration statement that includes this prospectus.

General

        We may issue warrants for the purchase of common stock or preferred stock in one or more series. We may issue warrants independently or together with common stock or preferred stock, and the warrants may be attached to or separate from these securities.

        We will evidence each series of warrants by warrant certificates that we will issue under a separate agreement. We may enter into a warrant agreement with a warrant agent. We will indicate the name and address of the warrant agent in the applicable prospectus supplement relating to a particular series of warrants.

        Before exercising their warrants, holders of warrants will not have any of the rights of holders of the securities purchasable upon such exercise, including in the case of warrants to purchase common stock or preferred stock, the right to receive dividends, if any, or, payments upon our liquidation, dissolution or winding up or to exercise voting rights, if any.

Additional Information

        We will describe in the applicable prospectus supplement the terms of the series of warrants, including:

    the offering price and aggregate number of warrants offered;

    the currency for which the warrants may be purchased;

    if applicable, the designation and terms of the securities with which the warrants are issued and the number of warrants issued with each such security or each principal amount of such security;

    if applicable, the date on and after which the warrants and the related securities will be separately transferable;

    in the case of warrants to purchase common stock or preferred stock, the number of shares of common stock or preferred stock, as the case may be, purchasable upon the exercise of one warrant and the price at which these shares may be purchased upon such exercise;

    the effect of any merger, consolidation, sale or other disposition of our business on the warrant agreement and the warrants;

    the terms of any rights to redeem or call the warrants;

    any provisions for changes to or adjustments in the exercise price or number of securities issuable upon exercise of the warrants;

    the dates on which the right to exercise the warrants will commence and expire;

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    the manner in which the warrant agreement and warrants may be modified;

    a discussion on any material or special United States federal income tax consequences of holding or exercising the warrants;

    the terms of the securities issuable upon exercise of the warrants; and

    any other specific terms, preferences, rights or limitations of or restrictions on the warrants.

Exercise of Warrants

        Each warrant will entitle the holder to purchase the securities that we specify in the applicable prospectus supplement at the exercise price that we describe in the applicable prospectus supplement. Unless we otherwise specify in the applicable prospectus supplement, holders of the warrants may exercise the warrants at any time up to 5 p.m., Eastern time, on the expiration date that we set forth in the applicable prospectus supplement. After the close of business on the expiration date, unexercised warrants will become void.

        Holders of the warrants may exercise the warrants by delivering the warrant certificate representing the warrants to be exercised together with specified information, and paying the required amount to the warrant agent in immediately available funds, as provided in the applicable prospectus supplement. We will set forth on the reverse side of the warrant certificate and in the applicable prospectus supplement the information that the holder of the warrant will be required to deliver to the warrant agent.

        Upon receipt of the required payment and the warrant certificate properly completed and duly executed at the corporate trust office of the warrant agent or any other office indicated in the applicable prospectus supplement, we will issue and deliver the securities purchasable upon such exercise. If fewer than all of the warrants represented by the warrant certificate are exercised, then we will issue a new warrant certificate for the remaining amount of warrants. If we so indicate in the applicable prospectus supplement, holders of the warrants may surrender securities as all or part of the exercise price for warrants.

Enforceability of Rights by Holders of Warrants

        Each warrant agent will act solely as our agent under the applicable warrant agreement and will not assume any obligation or relationship of agency or trust with any holder of any warrant. A single bank or trust company may act as warrant agent for more than one issue of warrants. A warrant agent will have no duty or responsibility in case of any default by us under the applicable warrant agreement or warrant, including any duty or responsibility to initiate any proceedings at law or otherwise, or to make any demand upon us. Any holder of a warrant may, without the consent of the related warrant agent or the holder of any other warrant, enforce by appropriate legal action its right to exercise, and receive the securities purchasable upon exercise of, its warrants.


DESCRIPTION OF OVERALLOTMENT PURCHASE RIGHTS

        We summarize below some of the provisions that will apply to the overallotment purchase rights unless the applicable prospectus supplement provides otherwise. This summary may not contain all information that is important to you. The complete terms of the overallotment purchase rights will be contained in the applicable overallotment purchase rights certificate and overallotment purchase rights agreement. These documents have been or will be included or incorporated by referencefiled as exhibits to the registration statement, of which this prospectus is a part. You should readpart, completely and with the overallotment purchase rights certificate andunderstanding that our actual future results may be materially different from what we expect. Our forward-looking statements do not reflect the overallotment purchase rights agreement. You should also read thepotential impact of any future acquisitions, merger, dispositions, joint ventures or investments we may undertake. We qualify all of our forward-looking statements by these cautionary statements.


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prospectus supplement, which will contain additional information and which may update or change some of the information below.

GeneralUSE OF PROCEEDS

 We may issue, together with common or preferred stock or warrants as units or separately, overallotment purchase rights for the purchase of

All shares of our common or preferred stock or warrants. The terms of each overallotment purchase right will be discussed in the applicable prospectus supplement relating to the particular series of overallotment purchase rights. The form(s) of certificate representing the overallotment purchase rights and/or the overallotment purchase right agreement, will be, in each case, filed with the SEC as an exhibit to a document incorporated by reference in the registration statement of which this prospectus is a part on or prior to the date of any prospectus supplement relating to an offering of the particular overallotment purchase right. The following summary of material provisions of the overallotment purchase rights and the overallotment purchase right agreements is subject to, and qualified in their entirety by reference to, all the provisions of the overallotment purchase rights agreement and overallotment purchase rights certificate applicable to a particular series of overallotment purchase rights.

        The prospectus supplement relating to any series of overallotment purchase rights that areCommon Stock offered by this prospectus are being registered for the accounts of the selling stockholders, and we will describe, among other things,not receive any proceeds from the following terms to the extent they are applicable to that seriessale of overallotment purchase rights:

    the procedures and conditions relating tothese shares of Common Stock. However, we will receive proceeds from the exercise of the overallotmentWarrants if the Warrants are exercised for cash. We intend to use those proceeds, if any, for general corporate purposes.

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    Selling stockholders

    Up to 5,682,765 shares of our Common Stock are currently being offered by the selling stockholders.

    Private Placement

    On January 28, 2021, we entered into the Securities Purchase Agreement with the Purchasers, pursuant to which we issued and sold to the Purchasers in the Private Placement an aggregate of (i) 2,758,624 shares of Common Stock and (ii) accompanying Common Warrants to purchase rights;

    up to 2,758,624 shares of Common Stock, at a combined purchase price of $3.625 per Share and accompanying Common Warrant to purchase one share, for gross proceeds of approximately $10 million. The Private Placement closed on February 1, 2021.

    The Common Warrants have an exercise price of $3.50 per share. The Common Warrants are immediately exercisable and may be exercised at any time after their original issuance until August 3, 2026. A holder of a Common Warrant may not exercise any portion of such holder’s Common Warrants to the extent that the holder, together with its affiliates, would beneficially own more than 4.99% (or, at the election of the holder, 9.99%) of our outstanding shares of Common Stock immediately after exercise, except that upon at least 61 days’ prior notice from the holder to us, the holder may increase the beneficial ownership limitation to up to 9.99% of the number of shares of our common or preferred stock or warrants, ifCommon Stock outstanding immediately after giving effect to the exercise. If at any issued withtime of exercise, there is no effective registration statement under the overallotment purchase rights;

    Securities Act registering the date, if any, on and after which the overallotment purchase rights and any related shares of our common or preferred stock or warrants will be separately transferable;

    the offering priceresale of the overallotment purchase rights, if any;

    Common Warrant Shares by the number of shares of our common or preferred stock or warrants whichselling shareholders, the Common Warrants may also be purchased upon exercise of the overallotment purchase rights and the price or prices at which the shares or warrants may be purchased upon exercise;

    the date on which the right to exercise the overallotment purchase rights will begin and the date on which the right will expire;

    a discussion of the material United States federal income tax considerations applicable to the exercise of the overallotment purchase rights;

    anti-dilution provisions of the overallotment purchase rights, if any;

    call provisions of the overallotment purchase rights, if any; and

    any other material terms of the overallotment purchase rights.

        Each overallotment purchase right may entitle the holder to purchase for cash,exercised, in whole or in limited circumstances,part, by effectingmeans of a cashless exercise for, the number of shares of our common or preferred stock or warrants at the exercise price that is described in the applicable prospectus supplement. Overallotment purchase rights will be exercisable during the period of time described in the applicable prospectus supplement. After that period, unexercised overallotment purchase rights will be void. Overallotment purchase rights may be exercised in the manner described in the applicable prospectus supplement.


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        A holder of an overallotment purchase right will not have any of the rights ofaccording to a holder of our common or preferred stock before the stock is purchased upon exercise of the overallotment purchase right. Therefore, before an overallotment purchase right is exercised, the holder of the overallotment purchase right will not be entitled to receive any dividend payments or exercise any voting or other rights associated with shares of our common or preferred stock which may be purchased when the overallotment purchase right is exercised.

Transfer Agent and Registrar

        The transfer agent and registrar, if any, for any overallotment purchase rights will beformula set forth in the applicable prospectus supplement.


DESCRIPTION OF UNITS
Common Warrants.

 We may issue units comprised of one or more of

In connection with the Private Placement, we entered into the Registration Rights Agreement with the Purchasers, pursuant to which, among other securities described in this prospectus in any combination. Each unit will be issued so that the holder of the unit is also the holder of each security included in the unit. Thus, the holder of a unit will have the rightsthings, we agreed to prepare and obligations of a holder of each included security. The unit agreement under which a unit is issued may provide that the securities included in the unit may not be held or transferred separately, at any time or at any time before a specified date. The applicable prospectus supplement may describe:

    the designation and terms of the units and of the securities comprising the units, including whether and under what circumstances those securities may be held or transferred separately;

    any provisions for the issuance, payment, settlement, transfer or exchange of the units or of the securities comprising the units;

    the terms of the unit agreement governing the units;

    United States federal income tax considerations relevant to the units; and

    whether the units will be issued in fully registered global form.

        This summary of certain general terms of units and any summary description of units in the applicable prospectus supplement do not purport to be complete and are qualified in their entirety by reference to all provisions of the applicable unit agreement. The forms of the unit agreements and other documents relating to a particular issue of units will be filedfile with the SEC each timea registration statement on Form S-3 to register for resale the Shares and the Common Warrants Shares by February 2, 2021 at 9:30 a.m., New York Time. We have also agreed to cause such registration statement to become effective under the Securities Act by the 60th day following the date of the Registration Rights Agreement (or by the 90th day following the date of the Registration Rights Agreement if there is a review of the registration statement by the SEC). In addition, we issue units,agreed that, upon the registration statement being declared effective, we will use best efforts to keep such registration statement effective until the earlier of (i) the selling stockholders have sold all of the Shares and you should read those documents for provisions thatthe Common Warrant Shares or (ii) such shares may be importantresold by the selling stockholders pursuant to you.


PLAN OF DISTRIBUTION
Rule 144 of the Securities Act without any public information requirements or volume or manner of sale limitations.

 We may sell

Pursuant to the securitiesRegistration Rights Agreement, we are registering the Shares and the Common Warrant Shares in order to permit the selling stockholders to offer such shares for resale from time to time pursuant to underwritten public offerings, direct salesthis prospectus. The selling stockholders may also sell, transfer or otherwise dispose of all or a portion of their shares in transactions exempt from the registration requirements of the Securities Act, or pursuant to another effective registration statement covering those shares.

Wainwright acted as the exclusive placement agent for the Private Placement. Pursuant to a certain engagement letter, dated September 18, 2020, as amended, we issued to the designees of Wainwright Placement Agent Warrants to purchase up to 165,517 shares of Common Stock, equal to 6.0% of the aggregate number of Shares. The Placement Agent Warrants are exercisable immediately, have an exercise price of $4.5313 per share (equal to 125% of the offering price per Share and accompanying Common Warrant), and terminate on August 3, 2026. A holder of a Placement Agent Warrant may not exercise any portion of such holder’s Placement Agent Warrants to the extent that the holder, together with its affiliates, would beneficially own more than 4.99% (or, at the election of the holder, 9.99%) of our outstanding shares of Common Stock immediately after exercise, except that upon at least 61 days’ prior notice from the holder to us, the holder may increase the beneficial ownership limitation to up to 9.99% of the number of shares of Common Stock outstanding immediately after giving effect to the exercise. If at any time of exercise, there is no effective registration statement under the Securities Act registering the resale of the Placement Agent Warrant Shares by the selling shareholders, then the Placement Agent Warrants may also be exercised, in whole or in part, by means of a cashless exercise according to a formula set forth in the Placement Agent Warrants.

6

The selling stockholders do not have any registration rights in connection with the Placement Agent Warrants.

The Shares, the Common Warrants, the Common Warrant Shares, the Placement Agent Warrants and the Placement Agent Warrant Shares have not been registered under the Securities Act and were offered pursuant to the exemption from registration provided in Section 4(a)(2) under the Securities Act, and Rule 506(b) promulgated thereunder.

Relationship with the Selling Stockholders

Except with respect to the following, none of the selling stockholders has, or within the past three years has had, any position, office or other material relationship with us.

The selling stockholders participated in the Private Placement.

Affiliates of Wainwright

Each of Michael Vasinkevich, Noam Rubinstein, Craig Schwabe and Charles Worthman are affiliated with Wainwright, a registered broker-dealer, which (A) served as our placement agent for the Private Placement and as our underwriter for our public negotiated transactions, block trades offering of Common Stock that closed on November 2, 2020 and (B) serves as agent for our at-the-market offering pursuant to an At The Market Offering Agreement dated December 3, 2020, in each case for which it received cash and/or warrant compensation. In connection with all or certain of the offerings Wainwright served as a combinationplacement agent or an underwriter, each of these methods.Michael Vasinkevich, Noam Rubinstein, Craig Schwabe and Charles Worthman, as a designee of Wainwright, has received warrants to purchase shares of our common stock.

Information About Selling Stockholder Offering

The shares of Common Stock being offered by the selling stockholders are those previously issued to the selling stockholders, and those issuable to the selling stockholders, upon the exercise of the Warrants. For additional information regarding the issuances of those shares of Common Stock, see “—Private Placement” above. We may sellare registering the securitiesshares of Common Stock in order to or through underwriters or dealers, through agents, or directlypermit the selling stockholders to one or more purchasers. We may distribute securitiesoffer the shares for resale from time to time in one or more transactions:time.

    at a fixed price or prices, which may be changed;

    at market prices prevailing at

    The table below lists the timeselling stockholders and other information regarding the ownership of sale;

    at prices relatedthe shares of Common Stock by each of the selling stockholders. The second column lists the number of shares of Common Stock owned by each selling stockholder, based on its ownership of the shares of Common Stock and securities convertible into shares of Common Stock, as of February 1, 2021, assuming exercise of the securities convertible into shares of Common Stock held by the selling stockholders on that date, without regard to such prevailing market prices; or

    at negotiated prices.

    Table of Contentsany limitations on exercises.

     A

    The third column lists the shares of Common Stock being offered by this prospectus supplement or supplements (and any related free writing prospectus that we may authorize to be provided to you) will describeby the selling stockholders.

    In accordance with the terms of the offeringRegistration Rights Agreement, this prospectus generally covers the resale of the securities, including,sum of (i) the Shares issued to the extent applicable:

      selling stockholders in the name or names“—Private Placement” described above and (ii) the maximum number of Common Warrant Shares. In addition, this prospectus covers the maximum number of the underwriters, if any;

      Placement Agent Warrant Shares. The table below assumes that the purchase priceoutstanding Warrants were exercised in full as of the securities or other consideration therefor,trading day immediately preceding the date this registration statement was initially filed with the SEC, each as of the trading day immediately preceding the applicable date of determination and the proceeds, if any, we will receive from the sale;

      any over-allotment options under which underwriters may purchase additional securities from us;

      any agency fees or underwriting discounts and other items constituting agents' or underwriters' compensation;

      any public offering price;

      any discounts or concessions allowed or reallowed or paidall subject to dealers; and

      any securities exchange or market on which the securities may be listed.

            Only underwriters namedadjustment as provided in the prospectus supplement will be underwritersRegistration Rights Agreement, without regard to any limitations on the exercise of the securitiesWarrants. The fourth column assumes the sale of all of the shares offered by the prospectus supplement.

            If underwriters are used inselling stockholders pursuant to this prospectus. The fifth column lists the sale, they will acquirepercentages of shares of Common Stock owned by the securities for their ownselling stockholders after this offering, taking account and may resell the securities from time to time in one or more transactions at a fixed public offering price or at varying prices determined at the time of sale. The obligations of the underwriters to purchase the securities will be subject to the conditionsany limitations on exercise set forth in the applicable underwriting agreement. Weconvertible securities.

    7

    Under the terms of the Warrants, a selling stockholder may offernot exercise the Warrants to the extent such exercise would cause such selling stockholder, together with its affiliates and attribution parties, to beneficially own a number of shares of Common Stock which would exceed 4.99% or 9.99%, as applicable, of our then outstanding Common Stock following such exercise, excluding for purposes of such determination shares of Common Stock issuable upon the exercise of the Warrants, which have not been exercised. The number of shares in the second column does not reflect this limitation. The selling stockholders may sell all, some or none of their shares in this offering. See “Plan of Distribution.”

    Name of Selling stockholder 

    Number of

    shares of

    Common

    Stock

    Owned

    Prior to

    Offering

      

    Maximum

    Number of

    shares of

    Common

    Stock to be

    Sold

    Pursuant to

    this Prospectus

      

    Number of

    shares of

    Common

    Stock

    Owned

    After

    Offering

      

    Percentage

    of Common

    Stock

    Owned

    After

    Offering(1)

     
    Lind Global Macro Fund, LP (2)  1,379,312   1,379,312(8)  -   - 
    Intracoastal Capital, LLC (3)  1,379,312   1,379,312(9)  -   - 
    FiveT Capital AG / FiveT Investment Management (4)  689,656   689,656(10)  -   - 
    District 2 Capital Fund LP (5)  689,656   689,656(11)  -   - 
    Bigger Capital Fund, LP (6)  689,656   689,656(12)  -   - 
    CVI investments, Inc. (7)  692,329   689,656(13)  2,673   * 
    Michael Vasinkevich  317,000   106,138(14)  210,862   2.1%
    Noam Rubinstein  157,640   52,138(15)  105,502   1.1%
    Craig Schwabe  14,348   5,586(16)  8,762   * 
    Charles Worthman  7,239   1,655(17)  5,584   * 

    (1)Based on shares of Common Stock outstanding as of February 1, 2021. “*” denotes less than 1%.
    (2)Jeff Easton is the Managing Member of Lind Global Partners, LLC, which is the General Partner of Lind Global Macro Fund, LP, and in such capacity has the right to vote and dispose of the securities held by such entity. Mr. Easton disclaims beneficial ownership over the securities listed except to the extent of his pecuniary interest therein. The address for Lind Global Macro Fund, LP is 444 Madison Avenue, 41st Floor, New York, NY 10022.
    (3)Mitchell P. Kopin (“Mr. Kopin”) and Daniel B. Asher (“Mr. Asher”), each of whom are managers of Intracoastal Capital LLC (“Intracoastal”), have shared voting control and investment discretion over the securities reported herein that are held by Intracoastal. As a result, each of Mr. Kopin and Mr. Asher may be deemed to have beneficial ownership (as determined under Section 13(d) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”)) of the securities reported herein that are held by Intracoastal.
    (4)Johannes Minho Roth has sole voting and dispositive power over the securities held for the account of this selling stockholder. The selling stockholder’s address is Allmendstrasse 140, 8041 Zurich, Switzerland.
    (5)Michael Bigger is a managing member of the general partner of District 2 Capital Fund LP and has sole voting and dispositive power over the securities held by District 2 Capital Fund LP. The principal business address of District 2 Capital Fund LP is 175 West Carver Street, Huntington, NY 11743.
    (6)Michael Bigger is a managing member of the general partner of Bigger Capital Fund, LP and has sole voting and dispositive power over the securities held by Bigger Capital Fund, LP. The principal business address of Bigger Capital Fund, LP is 11434 Glowing Sunset, Las Vegas, NV 89135.
    (7)Heights Capital Management, Inc., the authorized agent of CVI Investments, Inc. (“CVI”), has discretionary authority to vote and dispose of the shares held by CVI and may be deemed to be the beneficial owner of these shares. Martin Kobinger, in his capacity as Investment Manager of Heights Capital Management, Inc., may also be deemed to have investment discretion and voting power over the shares held by CVI. Mr. Kobinger disclaims any such beneficial ownership of the shares. CVI Investments, Inc. is affiliated with one or more FINRA member, none of whom are currently expected to participate in the sale pursuant to this prospectus of Shares or Common Warrant Shares purchased by CVI in the Private Placement.
    (8)Represents (i) 689,656 shares of Common Stock and (ii) 689,656 shares of Common Stock issuable upon the exercise of the Common Warrants issued in the Private Placement.
    (9)Represents (i) 689,656 shares of Common Stock and (ii) 689,656 shares of Common Stock issuable upon the exercise of the Common Warrants issued in the Private Placement.
    (10)Represents (i) 344,828 shares of Common Stock and (ii) 344,828 shares of Common Stock issuable upon the exercise of the Common Warrants issued in the Private Placement.
    (11)Represents (i) 344,828 shares of Common Stock and (ii) 344,828 shares of Common Stock issuable upon the exercise of the Common Warrants issued in the Private Placement.
    (12)Represents (i) 344,828 shares of Common Stock and (ii) 344,828 shares of Common Stock issuable upon the exercise of the Common Warrants issued in the Private Placement.
    (13)Represents (i) 344,828 shares of Common Stock and (ii) 344,828 shares of Common Stock issuable upon the exercise of the Common Warrants issued in the Private Placement.
    (14)Represents 106,138 shares of Common Stock issuable upon the exercise of the Placement Agent Warrants.
    (15)Represents 52,138 shares of Common Stock issuable upon the exercise of the Placement Agent Warrants.
    (16)Represents 5,586 shares of Common Stock issuable upon the exercise of the Placement Agent Warrants.
    (17)Represents 1,655 shares of Common Stock issuable upon the exercise of the Placement Agent Warrants.

    8

    PLAN OF DISTRIBUTION

    Each selling stockholder of the shares of Common Stock and any of their pledgees, assignees and successors-in-interest may, from time to time, sell any or all of their shares of Common Stock covered hereby on the Nasdaq Capital Market or any other stock exchange, market or trading facility on which the shares of Common Stock are traded or in private transactions. These sales may be at fixed or negotiated prices. A selling stockholder may use any one or more of the following methods when selling securities:

    ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers;
    block trades in which the broker-dealer will attempt to sell the securities as agent but may position and resell a portion of the block as principal to facilitate the transaction;
    purchases by a broker-dealer as principal and resale by the broker-dealer for its account;
    an exchange distribution in accordance with the rules of the applicable exchange;
    privately negotiated transactions;
    settlement of short sales;
    in transactions through broker-dealers that agree with the selling stockholders to sell a specified number of such shares of Common Stock at a stipulated price per security;
    through the writing or settlement of options or other hedging transactions, whether through an options exchange or otherwise;
    a combination of any such methods of sale; or
    any other method permitted pursuant to applicable law.

    The selling stockholders may also sell shares of Common Stock under Rule 144 or any other exemption from registration under the Securities Act, if available, rather than under this prospectus.

    Broker-dealers engaged by the selling stockholders may arrange for other brokers-dealers to participate in sales. Broker-dealers may receive commissions or discounts from the selling stockholders (or, if any broker-dealer acts as agent for the purchaser of securities, from the purchaser) in amounts to be negotiated, but, except as set forth in a supplement to this prospectus, in the case of an agency transaction not in excess of a customary brokerage commission in compliance with FINRA Rule 2440; and in the case of a principal transaction a markup or markdown in compliance with FINRA IM-2440.

    In connection with the sale of shares of Common Stock or interests therein, the selling stockholders may enter into hedging transactions with broker-dealers or other financial institutions, which may in turn engage in short sales of the shares of Common Stock in the course of hedging the positions they assume. The selling stockholders may also sell shares of Common Stock short and deliver these securities to close out their short positions, or loan or pledge the securities to broker-dealers that in turn may sell these shares of Common Stock. The selling stockholders may also enter into option or other transactions with broker-dealers or other financial institutions or create one or more derivative securities which require the public through underwriting syndicates representeddelivery to such broker-dealer or other financial institution of shares of Common Stock offered by managing underwritersthis prospectus, which shares of Common Stock such broker-dealer or by underwriters without a syndicate. Subjectother financial institution may resell pursuant to certain conditions,this prospectus (as supplemented or amended to reflect such transaction).

    The selling stockholders and any broker-dealers or agents that are involved in selling the underwriters willshares of Common Stock may be obligateddeemed to purchase allbe “underwriters” within the meaning of the securities offeredSecurities Act in connection with such sales. In such event, any commissions received by the prospectus supplement, other than securities covered by any over-allotment option. Any public offering pricesuch broker-dealers or agents and any profit on the resale of the shares of Common Stock purchased by them may be deemed to be underwriting commissions or discounts under the Securities Act. Each selling stockholder has informed us that it does not have any written or concessions allowedoral agreement or reallowed or paid to dealers may change from time to time. We may use underwriters with whom we have a material relationship. We will describe in the prospectus supplement, naming the underwriter, the nature of any such relationship.

            We may sell securitiesunderstanding, directly or through agents we designate from timeindirectly, with any person to time. We will name any agent involved indistribute the offering and sale of securities and we will describe any commissions we will pay the agent in the prospectus supplement. Unless the prospectus supplement states otherwise, our agent will act on a best-efforts basis for the period of its appointment.securities.

     

    9

    We may authorize agents or underwritersare required to solicit offerspay certain fees and expenses incurred by us incident to the registration of the shares of Common Stock. We have agreed to indemnify the selling stockholders against certain types of institutional investors to purchase securities from us at the public offering price set forth in the prospectus supplement pursuant to delayed delivery contracts providing for paymentlosses, claims, damages and delivery on a specified date in the future. We will describe the conditions to these contracts and the commissions we must pay for solicitation of these contracts in the prospectus supplement.

            We may provide agents and underwriters with indemnification against civil liabilities, including liabilities under the Securities Act.

    We agreed to keep this prospectus effective until the earlier of (i) the date on which the shares of Common Stock may be resold by the selling stockholders without registration and without regard to any volume or manner-of-sale limitations by reason of Rule 144, without the requirement for us to be in compliance with the current public information under Rule 144 under the Securities Act or contribution with respectany other rule of similar effect or (ii) all of the shares of Common Stock have been sold pursuant to payments thatthis prospectus or Rule 144 under the agentsSecurities Act or underwritersany other rule of similar effect. The resale shares will be sold only through registered or licensed brokers or dealers if required under applicable state securities laws. In addition, in certain states, the resale shares covered hereby may make with respect to these liabilities. Agents and underwriters may engage in transactions with,not be sold unless they have been registered or perform servicesqualified for ussale in the ordinary course of business.applicable state or an exemption from the registration or qualification requirement is available and is complied with.

     All securities we may offer, other than common stock, will be new issues of securities with no established trading market. Any underwriters may make a market in these securities, but will not be obligated to do so

    Under applicable rules and may discontinue any market making at any time without notice. We cannot guarantee the liquidity of the trading markets for any securities.

            Any underwriter may engage in over-allotment, stabilizing transactions, short-covering transactions and penalty bids in accordance with Regulation M under the Exchange Act. Over-allotment involves


    Table of Contents

    sales in excess of the offering size, which create a short position. Stabilizing transactions permit bids to purchase the underlying security so long as the stabilizing bids do not exceed a specified maximum price. Syndicate-covering or other short-covering transactions involve purchases of the securities, either through exercise of the over-allotment option or in the open market after the distribution is completed, to cover short positions. Penalty bids permit the underwriters to reclaim a selling concession from a dealer when the securities originally sold by the dealer are purchased in a stabilizing or covering transaction to cover short positions. Those activities may cause the price of the securities to be higher than it would otherwise be. If commenced, the underwriters may discontinue any of the activities at any time.

            Any underwriters or agents that are qualified market makers on the NASDAQ Capital Market engage in passive market making transactions in the common stock on the NASDAQ Capital Market accordance with Regulation Mregulations under the Exchange Act, duringany person engaged in the business daydistribution of the resale securities may not simultaneously engage in market making activities with respect to the Common Stock for the applicable restricted period, as defined in Regulation M, prior to the pricingcommencement of the offering, beforedistribution. In addition, the commencementselling stockholders will be subject to applicable provisions of offers orthe Exchange Act and the rules and regulations thereunder, including Regulation M, which may limit the timing of purchases and sales of the common stock. Passive market makers must comply with applicable volumeCommon Stock by the selling stockholders or any other person. We will make copies of this prospectus available to the selling stockholders and price limitations and must be identified as passive market makers. In general, a passive market maker must display its bid at a price not in excesshave informed them of the highest independent bid for such security; if all independent bids are lowered belowneed to deliver a copy of this prospectus to each purchaser at or prior to the passive market maker's bid, however, the passive market maker's bid must then be lowered when certain purchase limits are exceeded. Passive market making may stabilize the market pricetime of the securities at a level above that which might otherwise prevail insale (including by compliance with Rule 172 under the open market and, if commenced, may be discontinued at any time.Securities Act).

    10


    LEGAL MATTERS

     Unless otherwise indicated in the applicable prospectus supplement, the

    The validity of the issuance of the securities offered by this prospectus will be passed upon for us by Lowenstein Sandler LLP, Roseland, New Jersey. IfYork, New York.

    EXPERTS

    The consolidated financial statements of Cancer Genetics, Inc. and subsidiaries as of December 31, 2019 and for the validityyear ended December 31, 2019 have been audited by Marcum LLP, an independent registered public accounting firm, as stated in their report which is incorporated by reference herein, (which report includes an explanatory paragraph as to the Company’s ability to continue as a going concern and a paragraph regarding other matters including 1) the audit of the securities offered herebyrestatement for discontinued operations, 2) a reverse stock-split and 3) change in connection with offerings made pursuant to this prospectus are passedaccounting principle). Such financial statements have been incorporated by reference herein in reliance on the report of such firm, given upon by counsel for the underwriters, dealers or agents, if any, such counsel will be namedtheir authority as experts in the prospectus supplement relating to such offering.


    EXPERTS
    auditing and accounting.

     

    The consolidated financial statements as of December 31, 2018 and for the yearsyear then ended December 31, 2016 and 2015, incorporated in this prospectus by reference from the Company's Annual Report on Form 10-K filed with the SEC on March 23, 2017, have been audited by RSM US LLP, an independent registered public accounting firm, as stated in their report thereon (which report expresses an unqualified opinion on the financial statements, except for effects of the adjustments, if any, as might have been determined to be necessary had they been engaged to audit the Company’s restatement for discontinued operations and a reverse stock-split and emphasis of matter paragraphs stating 1) they were not engaged to audit the restatement for discontinued operations and a reverse stock-split, 2) for substantial doubt about the Company’s ability to continue as a going concern and 3) change in accounting principle), incorporated herein by reference, and have been incorporated in this prospectus in reliance upon such report and upon the authority of such firm as experts in accounting and auditing.

    The financial statements of StemoniX, Inc. as of and for the years end December 31, 2019 and December 31, 2018, incorporated in this Prospectus by reference from Cancer Genetics’ Registration Statement on Form S-4, have been audited by Deloitte & Touche LLP, an independent registered public accounting firm, as stated in their report which is incorporated herein by reference.reference (which report expresses an unqualified opinion on the financial statements and includes explanatory paragraphs referring to substantial doubt regarding StemoniX, Inc.’s ability to continue as a going concern and a change in accounting principle related to adoption of Accounting Standards Update 2016-02, “Leases” (Topic 842)). Such consolidated financial statements have been so incorporated in reliance upon the report of such firm given upon their authority as experts in accounting and auditing.


    INCORPORATIONDISCLOSURE OF CERTAIN DOCUMENTS BY REFERENCECOMMISSION POSITION
    ON INDEMNIFICATION FOR SECURITIES ACT LIABILITIES

     The following documents previously filed

    Section 145 of the DGCL provides that we may indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether civil, criminal or investigative (other than an action by us or in our right) by reason of the fact that he is or was our director, officer, employee or agent, or is or was serving at our request as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against expenses (including attorneys’ fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by him or her in connection with such action, suit or proceeding if he acted in good faith and in a manner he or she reasonably believed to be in or not opposed to our best interests, and, with respect to any criminal action or proceeding, had no reasonable cause to believe his or her conduct was unlawful. Section 145 further provides that we similarly may indemnify any such person serving in any such capacity who was or is a party or is threatened to be made a party to any threatened, pending or completed action or suit by is or in our right to procure judgment in our favor, against expenses actually and reasonably incurred in connection with the SEC are incorporateddefense or settlement of such action or suit if he or she acted in this prospectus by reference:good faith and in a manner he reasonably believed to be in or not opposed to our best interests and except that no indemnification shall be made in respect of any claim, issue or matter as to which such person shall have been adjudged to be liable to us unless and only to the extent that the Delaware Court of Chancery or such other court in which such action or suit was brought shall determine upon application that, despite the adjudication of liability but in view of all the circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery or such other court shall deem proper.

     (a)   

    11

    Our certificate of incorporation, as amended, limits the liability of our directors to the fullest extent permitted by Delaware law. In addition, we have entered into indemnification agreements with certain of our directors and officers whereby we have agreed to indemnify those directors and officers to the fullest extent permitted by law, including indemnification against expenses and liabilities incurred in legal proceedings to which the director or officer was, or is threatened to be made, a party by reason of the fact that such director or officer is or was a director, officer, employee or agent of the Company, provided that such director or officer acted in good faith and in a manner that the director or officer reasonably believed to be in, or not opposed to, the best interests of the Company.

    We have director and officer liability insurance to cover liabilities our directors and officers may incur in connection with their services to us, including matters arising under the Securities Act. Our certificate of incorporation and bylaws also provide that we will indemnify our directors and officers who, by reason of the fact that he or she is one of our officers or directors of our company, is involved in any action, suit or proceeding, whether civil, criminal, administrative or investigative, related to their board role with the company.

    Insofar as indemnification for liabilities arising under the Securities Act may be permitted to our directors, officers and controlling persons pursuant to the foregoing provisions, or otherwise, we have been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, we will, unless in the opinion of our counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by us is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

    WHERE YOU CAN FIND MORE INFORMATION

    We are subject to the informational requirements of the Exchange Act, and in accordance therewith file annual, quarterly and current reports, proxy statements and other information with the SEC. The SEC maintains a website that contains reports, proxy and information statements and other information regarding registrants that file electronically with the SEC. The address of the SEC’s website is www.sec.gov.

    We make available free of charge on or through our website at www.cancergenetics.com, our Annual ReportReports on Form 10-K, for the fiscal year ended December 31, 2016, filed with the SEC on March 23, 2017.

            (b)   Our Proxy Statement on Schedule 14A for our 2017 Annual Meeting of Stockholders, filed with the SEC on April 21, 2017.

            (c)   Our Quarterly ReportReports on Form 10-Q, for the quarterly period ended March 31, 2017 filed with the SEC on May 12, 2017.

            (d)   Our Current Reports on Form 8-K and amendments thereto,to those reports filed or furnished pursuant to Section 13(a) or 15(d) of the Exchange Act, as soon as reasonably practicable after we electronically file such material with or otherwise furnish it to the SEC.

    We have filed with the SEC a registration statement under the Securities Act, relating to the offering of these securities. The registration statement, including the attached exhibits, contains additional relevant information about us and the securities. This prospectus does not contain all of the information set forth in the registration statement. You can obtain a copy of the registration statement for free at www.sec.gov. The registration statement and the documents referred to below under “Incorporation of Certain Information By Reference” are also available on January 6, February 16, February 22, March 23, March 24,our website, www.cancergenetics.com.

    We have not incorporated by reference into this prospectus the information on our website, and May 12, 2017,you should not consider it to be a part of this prospectus.

    12

    INCORPORATION OF CERTAIN INFORMATION BY REFERENCE

    The SEC allows us to “incorporate by reference” the information we have filed with it, which means that we can disclose important information to you by referring you to those documents. The information we incorporate by reference is an important part of this prospectus, and later information that we file with the SEC will automatically update and supersede this information. We incorporate by reference the documents listed below and any future documents (excluding any information deemed furnished pursuant to ItemItems 2.02 or Itemand 7.01 of any such Current Report on Form 8-K).


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            (e)   Description of our common stock contained in the Registration Statement on Form 8-A, declared effective on August 12, 2013 (including any amendment or report filed we file with the SEC forpursuant to Sections l3(a), l3(c), 14 or l5(d) of the purposeExchange Act, subsequent to the date of updating such description).this prospectus and prior to the termination of the offering:

     

    our Annual Report on Form 10-K for the year ended December 31, 2019, filed with the SEC on May 29, 2020;
    our Quarterly Reports on Form 10-Q for the quarters ended March 31, 2020, June 30, 2020 and September 30, 2020, filed with the SEC on June 24, 2020 (as amended on July 6, 2020), August 13, 2020 and November 12, 2020, respectively;

    our Current Reports on Form 8-K filed with the SEC on February 27, 2020, March 30, 2020, May 14, 2020, June 12, 2020, August 24, 2020, September 3, 2020, September 15, 2020, September 24, 2020, September 30, 2020, October 19, 2020, November 2, 2020, November 20, 2020, December 3, 2020 (two such filings on such date), January 7, 2021, January 28, 2021 and February 1, 2021 (other than any portions thereof deemed furnished and not filed);

     ●our Registration Statement on Form S-4 (File No. 333-249513) filed with the SEC on October 16, 2020; and
    the description of our common stock, par value $0.0001 per share, contained in our Form 8-A filed on August 12, 2013, including any amendment or report filed for the purpose of updating such description.

    All reports and other documents filed by us pursuant tothat we file with the SEC under Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act after the date of the initial registration statement and prior to effectiveness of the registration statement, shalland after the date of this prospectus but before the termination of the offering of the securities hereunder will also be deemedconsidered to be incorporated by reference ininto this prospectus and to be a apart hereof from the date of filing of such reports and documents. All reports and other documents that we file pursuant to Section 13(a) and 13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective amendment which indicates that all securities offered hereunder have been sold or which deregisters all such securities then remaining unsold shall be deemed to be incorporated by reference in this prospectus and to be a part hereof from the date of filing of suchthese reports and documents, and will supersede the information herein; provided, however, that all reports, exhibits and other information that we "furnish"“furnish” to the SEC will not be considered incorporated by reference into this prospectus.

    We willundertake to provide without charge to each person including(including any beneficial owner, to whomowner) who receives a prospectus is delivered, copiescopy of these filings, excluding all exhibits unless an exhibit has been specifically incorporated by reference in such filings, at no cost,this prospectus, upon written or oral request, made to:

    Cancer Genetics, Inc.
    201 Route 17 North, 2nd Floor
    Rutherford, NJ 07070
    (201) 528-9200
    Attention: Corporate Secretary


    WHERE YOU CAN FIND MORE INFORMATION

            We have filed a registration statement on Form S-3 with the Securities and Exchange Commission under the Securities Actcopy of 1933. This prospectus omits some information and exhibits included in the registration statement, copies of which may be obtained upon payment of a fee prescribed by the Commission or may be examined free of charge at the principal officeall of the SEC in Washington, D.C.

            Wepreceding documents that are subject toincorporated by reference (other than exhibits, unless the informational requirements of the Securities Exchange Act of 1934 and in accordance therewith file reports, proxy statements and other information with the SEC. The reports, proxy statements and other information filedexhibits are specifically incorporated by us with the SEC can be inspected and copied at the Public Reference Room maintained by the SEC at 100 Fifth Street, N.E., Washington, D.C. 20549. Copies of filings can be obtained from the Public Reference Room maintained by the SEC by calling the SEC at 1-800-SEC-0330. In addition, the Commission maintains a website that contains reports, proxy and informational statements and other information filed electronically with the SEC athttp://www.sec.govreference into these documents).

    You may request orally or in writing, a copy of these documents, which will be provided to you at no cost, by contacting our Corporate Secretary at Cancer Genetics, Inc., 201 Route 17 North, 2nd Floor, Rutherford, NJ 07070, telephone (201) 528-9200.materials in the manner set forth under the heading “Additional Information,” above.

    13

    PART II

     You should rely only on the information contained in this prospectus, including information incorporated by reference as described above, or any prospectus supplement that we have specifically referred you to. We have not authorized anyone else to provide you with different information. You should not assume that the information in this prospectus or any prospectus supplement is accurate as of any date other than the date on the front of those documents or that any document incorporated by reference is accurate as of any date other than its filing date. You should not consider this prospectus to be an offer or solicitation relating to the securities in any jurisdiction in which such an offer or solicitation relating to the securities is not authorized. Furthermore, you should not consider this prospectus to be an offer or solicitation relating to the securities if the person making the offer or solicitation is not qualified to do so, or if it is unlawful for you to receive such an offer or solicitation.


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    $100,000,000

    Common Stock
    Preferred Stock
    Warrants
    Overallotment Purchase Rights
    Units

    LOGO



    PROSPECTUS



    , 2017


    Table of Contents


    PART II

    INFORMATION NOT REQUIRED IN PROSPECTUS

    Item 14. Item 14.    Other Expenses of Issuance and Distribution.

    The fees and Distribution.

            The following table sets forth the various expenses to be incurredpayable by us in connection with the registration of the securities being registered hereby, all of which will be borne by us. All amounts shown are estimates except the SEC registration fee.

    SEC registration fee

     $11,590 

    Transfer agent's and trustee's fees and expenses

      * 

    Printing and engraving expenses

      * 

    Legal fees and expenses

      * 

    Accounting fees and expenses

      * 

    Miscellaneous

      * 

    Total expenses

     $* 

    *
    Fees and expenses (other than the SEC registration fee to be paid upon the filing of this registration statement) will depend on the securities offered, the number of issuances and the nature of offerings, and cannot bestatement are estimated at this time.
    as follows:

    Securities and Exchange Commission Registration Fee $2,300 
    Accounting Fees and Expenses  75,000 
    Legal Fees and Expenses  15,000 
    Printing Fees and Expenses   
    Transfer Agent Fees and Expenses  3,000 
    Miscellaneous Fees and Expenses  1,000 
    Total $96,300 

    Item 15.Indemnification of Directors and Officers.

    Item 15.    Indemnification of Directors and Officers.

    We are incorporated under the laws of the State of Delaware. Section 145 of the Delaware General Corporation Law authorizes a court to award, or a corporation'scorporation’s board of directors to grant, indemnity to directors and officers in terms sufficiently broad to permit such indemnification under certain circumstances for liabilities, including reimbursement for expenses incurred, arising under the Securities Act of 1933, as amended, or the Securities Act.

     

    Our third amended and restated certificate of incorporation provides for indemnification of our directors and executive officers to the maximum extent permitted by the Delaware General Corporation Law, and our amended and restated bylaws provide for indemnification of our directors and executive officers to the maximum extent permitted by the Delaware General Corporation Law.

     

    In addition, we have entered into indemnification agreements with each of our current directors and executive officers. These agreements will require us to indemnify these individuals to the fullest extent permitted under Delaware law against liabilities that may arise by reason of their service to us and to advance expenses incurred as a result of any proceeding against them as to which they could be indemnified. We also intend to enter into indemnification agreements with our future directors and executive officers.

    Except as set forth elsewhere in this prospectus, there is no pending litigation or proceeding involving any of our directors or executive officers as to which indemnification is required or permitted, and we are not aware of any threatened litigation or proceeding that may result in a claim for indemnification.

    We have an insurance policy covering our officers and directors with respect to certain liabilities, including liabilities arising under the Securities Act.

    Item 16.    Exhibits.

    Item 16.Exhibits.

    The following exhibits are filed with this Registration Statement.

    Exhibit

    Description of ExhibitNumber

    1.1

     Form of Underwriting Agreement*Exhibit Description

    3.1

    4.1


    ThirdFourth Amended and Restated Certificate of Incorporation of Cancer Genetics, Inc., filed as(incorporated herein by reference to Exhibit 3.1 to quarterly reportour Quarterly Report on Form 10-Q filed with the SEC on May 15, 2013 and incorporated herein by reference.2013).


    4.2


    Form of certificate of amendment of the Third Amended and Restated Certificate of Incorporation, with respect to any preferred stock issued hereunder*

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    ExhibitDescription of Exhibit
    4.33.2 Amended and Restated Bylaws of Cancer Genetics, Inc., filed as(incorporated herein by reference to Exhibit 3.4 to our Registration Statement on Form S-1/A filed with the SEC on April 30, 2012 (File No. 333-178836) and incorporated2012).
    4.2Form of Common Warrant dated February 1, 2021 (incorporated herein by reference.


    4.4


    Specimen of Common Stock Certificate, filed asreference to Exhibit 4.1 to our Current Report on Form S-1/A8-K filed with the SEC on May 16, 2012 (File No. 333-178836) and incorporatedFebruary 1, 2021).

    II-1

    4.3Form of Placement Agent Warrant dated February 1, 2021 (incorporated herein by reference.reference to Exhibit 4.2 to our Current Report on Form 8-K filed with the SEC on February 1, 2021).

    5.1*

    4.5


    Form of Preferred Stock Certificate*


    4.6


    Form of Warrant Agreement*


    4.7


    Form of Warrant Certificate*


    4.8


    Form of Overallotment Purchase Right Agreement and Overallotment Purchase Right Certificate*


    4.9


    Form of Unit Agreement*


    5.1


    Opinion of Lowenstein Sandler LLP as to the legality of the securities†

    10.1

    23.1Form of Securities Purchase Agreement dated January 28, 2021 (incorporated herein by reference to Exhibit 10.1 to our Current Report on Form 8-K filed with the SEC on February 1, 2021).

    10.2

    Form of Registration Rights Agreement dated January 28, 2021 (incorporated herein by reference to Exhibit 10.2 to our Current Report on Form 8-K filed with the SEC on February 1, 2021).
    23.1*Consent of Marcum LLP
    23.2*Consent of RSM US LLP†LLP

    23.3*

    23.3

    Consent of Deloitte & Touche LLP
    23.4*
    Consent of Lowenstein Sandler LLP (included in Exhibit 5.1)

    24.1*

    24.1


    Power of Attorney (included onin the signature page ofpage)

    * Filed herewith.

    Item 17.Undertakings.

    A.The undersigned Registrant hereby undertakes:
    1.To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement)†statement:

    Filed herewith.

    *
    To be filed by amendment or as an exhibit to a document to be incorporated by reference herein in connection with an offering of the offered securities.

    a.to include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;
    b.to reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the “Calculation of Registration Fee” table in the effective registration statement; and
    c.to include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;

    Item 17.    Undertakings.

            The undersigned registrant hereby undertakes:

            (1)   To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

                (i)  To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;

               (ii)  To reflect in the prospectus any facts or events arising after the effective date of this registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this registration statement. Notwithstanding the foregoing, any increase or decrease in the volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than 20% change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement; and

              (iii)  To include any material information with respect to the plan of distribution not previously disclosed in this registration statement or any material change to such information in this registration statement;

    Provided,provided, however, that paragraphs (i)(1)(a), (ii)(1)(b) and (iii) above(1)(c) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the registrant pursuant to Section 13 or Section 15(d) of the Securities

    II-2


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    Exchange Act of 1934 that are incorporated by reference in the registration statement, or is contained in a form of prospectus filed pursuant to Rule 424(b) that is part of the registration statement.

            (2)   That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

            (3)   To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

            (4)   That, for the purpose of determining liability under the Securities Act of 1933 to any purchaser:

                (i)  If the registrants are relying on Rule 430B,

                (A)  Each prospectus filed by the registrant pursuant to Rule 424(b)(3) shall be deemed to be part of the registration statement as of the date the filed prospectus was deemed part of and included in the registration statement; and

                (B)  Each prospectus required to be filed pursuant to Rule 424(b)(2), (b)(5) or (b)(7) as part of a registration statement in reliance on Rule 430B relating to an offering made pursuant to Rule 415(a)(1)(i), (vii) or (x) for the purpose of providing the information required by Section 10(a) of the Securities Act of 1933 shall be deemed to be part of and included in the registration statement as of the earlier of the date such form of prospectus is first used after effectiveness or the date of the first contract of sale of securities in the offering described in the prospectus. As provided in Rule 430B, for liability purposes of the issuer and any person that is at that date an underwriter, such date shall be deemed to be a new effective date of the registration statement relating to the securities in the registration statement to which the prospectus relates, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. Provided, however, that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement will, as to a purchaser with a time of contract of sale prior to such effective date, supersede or modify any statement that was made in the registration statement or prospectus that was part of the registration statement or made in any such document immediately prior to such effective date; or

               (ii)  If the registrant is subject to Rule 430C, each prospectus filed pursuant to Rule 424(b) as part of a registration statement relating to an offering, other than registration statements relying on Rule 430B or other than prospectuses filed in reliance on Rule 430A, shall be deemed to be part of and included in the registration statement as of the date it is first used after effectiveness; provided, however, that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement will, as to a purchaser with a time of contract of sale prior to such first use, supersede or modify any statement that was made in the registration statement or prospectus that was part of the registration statement or made in any such document immediately prior to such date of first use.

            (5)   That, for the purpose of determining liability of the registrant under the Securities Act of 1933 to any purchaser in the initial distribution of the securities, the registrant undertakes that in a primary offering of securities of the registrant pursuant to this registration statement, regardless of the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to

    II-3


    Table of Contents

    such purchaser by means of any of the following communications, the undersigned registrant will be a seller to the purchaser and will be considered to offer or sell such securities to such purchaser:

                (i)  Any preliminary prospectus or prospectus of the undersigned registrant relating to the offering required to be filed pursuant to Rule 424;

               (ii)  Any free writing prospectus relating to the offering prepared by or on behalf of the registrant or used or referred to by the undersigned registrant;

              (iii)  The portion of any other free writing prospectus relating to the offering containing material information about an undersigned registrant or its securities provided by or on behalf of the undersigned registrant; and

              (iv)  Any other communication that is an offer in the offering made by an undersigned registrant to the purchaser.

            (6)   That, for purposes of determining any liability under the Securities Act of 1933, each filing of the registrant's annual report pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

            (7)   If this registration statement is permitted by Rule 430A, that:

                (i)  For purposes of determining any liability under the Securities Act of 1933, the information omitted from the form of prospectus filed as part of this registration statement in reliance upon Rule 430A and contained in a form of prospectus filed by the registrant pursuant to Rule 424(b) (1) or (4) or 497(h) under the Securities Act shall be deemed to be part of this registration statement as of the time it was declared effective.

               (ii)  For the purpose of determining any liability under the Securities Act of 1933, each post-effective amendment that contains a form of prospectus shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

            (8)   Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant to the forgoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Act and is, therefor, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed by the final adjudication of such issue.

    II-4


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    SIGNATURES

     

    2.That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
    3.To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
    4.That, for the purpose of determining liability under the Securities Act of 1933 to any purchaser:

    a.Each prospectus filed by the registrant pursuant to Rule 424(b)(3) shall be deemed to be part of the registration statement as of the date the filed prospectus was deemed part of and included in the registration statement; and

    II-2

    b.Each prospectus required to be filed pursuant to Rule 424(b)(2), (b)(5), or (b)(7) as part of a registration statement in reliance on Rule 430B relating to an offering made pursuant to Rule 415(a)(1)(i), (vii), or (x) for the purpose of providing the information required by Section 10(a) of the Securities Act of 1933 shall be deemed to be part of and included in the registration statement as of the earlier of the date such form of prospectus is first used after effectiveness or the date of the first contract of sale of securities in the offering described in the prospectus. As provided in Rule 430B, for liability purposes of the issuer and any person that is at that date an underwriter, such date shall be deemed to be a new effective date of the registration statement relating to the securities in the registration statement to which that prospectus relates, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. Provided, however, that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement will, as to a purchaser with a time of contract of sale prior to such effective date, supersede or modify any statement that was made in the registration statement or prospectus that was part of the registration statement or made in any such document immediately prior to such effective date.

    B.The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing of the registrant’s annual report pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan’s annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
    C.Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

    II-3

    SIGNATURES

    Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Rutherford, State of New Jersey, on May 25, 2017.February 1, 2021.

    CANCER GENETICS, INC.
      
    By:CANCER GENETICS, INC./s/ John A. Roberts

     

    Name:

    By: John A. Roberts

    Title:

    /s/ PANNA L. SHARMA

    Name:  Panna L. Sharma
    Title:    Chief Executive Officer
    (Principal Executive Officer)

     KNOW ALL PERSONS BY THESE PRESENTS, that each

    Power of Attorney

    Each person whose signature appears below constitutes andhereby appoints Panna Sharma and John A. Roberts, severally, acting alone and either of them, aswithout the other, his or her true and lawful attorneys-in-fact and agents,attorney-in-fact, with full power of substitution, and resubstitution, for him or her andwith the authority to execute in his or herthe name place and stead, inof each such person, any and all capacities,amendments (including without limitation, post-effective amendments) to this registration statement on Form S-3, to sign any and all amendments (including post-effective amendments) and supplementsadditional registration statements relating to the same offering of securities as this registration statement (or any other registration statement for the same offering that is effective upon filingare filed pursuant to Rule 462(b) underof the Securities Act of 1933, as amended) and to file the same, with all exhibits thereto and other documents in connection therewith,such registration statements with the Securities and Exchange Commission, hereby ratifyingtogether with any exhibits thereto and confirming all that eachother documents therewith, necessary or advisable to enable the registrant to comply with the Securities Act of said attorneys-in-fact1933, and agents, or his or her substitute or substitutes,any rules, regulations and requirements of the Securities and Exchange Commission in respect thereof, which amendments may do or cause to be done by virtue hereof.make such other changes in the registration statement as the aforesaid attorney-in-fact executing the same deems appropriate.

     

    Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.

    SignatureTitleDate
    Signature
    Title
    Date

     

     

     

     

     
    /s/ PANNA L. SHARMA

    Panna L. SharmaJohn A. Roberts
     Director and Chief Executive Officer
    February 1, 2021
    John A. Roberts(Principal Executive, Financial and Accounting Officer) May 25, 2017

    /s/ JOHN A. ROBERTS

    John A. Roberts

     

    Chief Operating Officer
    (Principal Financial Officer)

     

    May 25, 2017

    /s/ IGOR GITELMAN

    Igor Gitelman


    Chief Accounting Officer
    (Principal Accounting Officer)


    May 25, 2017

    /s/ JOHN PAPPAJOHN

    John Pappajohn


    Director (Chairman of the Board)


    May 25, 2017

    II-5


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    Signature
    Title
    Date





     
    /s/ EDMUND CANNON
    Geoffrey Harris

    Chairman of the BoardFebruary 1, 2021
    Geoffrey Harris
    /s/ Edmund Cannon Director May 25, 2017February 1, 2021

    /s/ RAJU S. K. CHAGANTI

    Raju S.K. Chaganti, Ph.D.Edmund Cannon

     

    Director

     

    May 25, 2017

    /s/ GEOFFREY HARRIS

    Geoffrey Harris

     

    Director

     

    May 25, 2017

    /s/ HOWARD MCLEOD

    Howard McLeod

     

    Director

     

    May 25, 2017February 1, 2021

    Howard McLeod
    /s/ FRANKLYNFranklyn G. PRENDERGAST
    Prendergast

    DirectorFebruary 1, 2021
    Franklyn G. Prendergast, M.D., Ph.D.
     

    Director

     

    May 25, 2017


    /s/ MICHAEL J. WELSH

    Michael Welsh

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    Director


    May 25, 2017

    II-6