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TABLE OF CONTENTS

Table of Contents

As filed with the Securities and Exchange Commission on April 30, 2020January 10, 2023

Registration No. 333-        


UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549



FORM S-3
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933



SENSEONICS HOLDINGS, INC.
(Exact name of registrant as specified in its charter)



Delaware47-1210911
Delaware
(State or other jurisdiction of

incorporation or organization)
47-1210911
(I.R.S. Employer

Identification Number)

20451 Seneca Meadows Parkway
Germantown, MD 20876-7005
(301) 515-7260

(Address, including zip code, and telephone number, including area code of registrant'sregistrant’s principal executive offices)



Timothy T. Goodnow
Chief Executive Officer
Senseonics Holdings, Inc.
20451 Seneca Meadows Parkway
Germantown, MD 20876-7005
(301) 515-7260

(Name, address, including zip code, and telephone number, including area code, of agent for service)



Copies to:


Darren K. DeStefano
Mark BallantyneReid S. Hooper
Cooley LLP
11951 Freedom Drive
Reston, VA 20190-564020210-5640
(703) 456-8000



From time to time after the effective date of this Registration Statement
(Approximate date of commencement of proposed sale to the public)



If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box:   o

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box:   ý

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.   o

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.   o

If this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following box.   o

If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following box.    o

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large“large accelerated filer," "accelerated” “accelerated filer," "smaller” “smaller reporting company," and "emerging“emerging growth company"company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer   ☐Accelerated filer   ☐Non-accelerated filer   ☒Smaller reporting company   ☒
Large accelerated filer oAccelerated filer ýNon-accelerated filer oSmaller reporting company ý

Emerging growth company o

Emerging growth company   ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.o



CALCULATION OF REGISTRATION FEE

   ☐

        
 
Title of each class of securities
to be registered

 Amount to be
Registered(1)(2)

 Proposed Maximum
Offering Price Per
Share(3)

 Proposed Maximum
Aggregate Offering
Price(3)

 Amount of
Registration Fee

 

Common Stock, par value $0.001 per share

 53,330,885 shares $0.605 $32,265,185.43 $4,188.02

 

(1)
This includes (i) 1,500,000 shares of common stock, (ii) 4,500,000 shares underlying warrants to purchase common stock, (iii) 47,330,885 shares of common stock, which is the maximum number of shares that can be issued pursuant to the conversion of $20.0 million of aggregate principal of convertible notes held by or issuable to the selling stockholders.

(2)
Pursuant to Rule 416 under the Securities Act of 1933, as amended, this registration statement also registers a currently indeterminate number of additional shares of the registrant's common stock that may be issuable with respect to the shares being registered hereunder as a result of stock splits, stock dividends, anti-dilution provisions of the convertible notes or similar transactions.

(3)
Estimated solely for the purpose of computing the amount of the registration fee pursuant to Rule 457(c) under the Securities Act of 1933, as amended. The calculation of the proposed maximum aggregate offering price of the common stock was based on the average of the high and low price for the common stock on April 24, 2020, as reported on the NYSE American.



The registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment thatwhich specifically states that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933 or until thethis registration statement shall become effective on such date as the Securities and Exchange Commission, acting pursuant to said Section 8(a), may determine.


The information in this preliminary prospectus is not complete and may be changed. The selling stockholdersWe may not sell these securities until the registration statement filed with the Securities and Exchange Commission isbecomes effective. This prospectus is not an offer to sell these securities and it is not soliciting an offer to buy these securities in any state where the offer or sale is not permitted.


SUBJECT TO COMPLETION, DATED April 30, 2020JANUARY 10, 2023

Senseonics Holdings, Inc.PRELIMINARY PROSPECTUS

[MISSING IMAGE: lg_senseonicstm-4c.jpg]
Up to 53,330,88510,000,000 Shares of Common Stock


LOGONonstatutory Stock Options

        This prospectus relates to the resale
Restricted Stock Units

We may issue, from time to time, of up to 53,330,885 shares of commonnonstatutory stock of Senseonics Holdings, Inc., or the Company, by the selling stockholders, including their transferees, pledgees or donees, or their respective successors. We are registering these shares on behalf of the selling stockholders, to be offered and sold by them from time to time, to satisfy certain registration rights that we have granted to the selling stockholders. The shares being registeredoptions exercisable for resale are issuable upon the conversion of our First Lien Term Notes due October 2021, shares of common stock issued as a commitment fee in April 2020 in connection with the First Lien Term Notes financing and shares issuable upon exercise of warrants that we issued in a concurrent transaction. We will not receive any proceeds from the sale of the shares offered by this prospectus or upon the conversion of the First Lien Term Notes.

        The selling stockholders identified in this prospectus, or their respective pledgees, donees, transferees and other successors-in-interest, may offer the shares from time to time through public or private transactions at prevailing market prices, at prices related to prevailing market prices or at privately negotiated prices. The selling stockholders may resell the shares of common stock directly or through one or more underwriters, broker-dealers or agents. For additional information on the methods of sale that may be used by the selling stockholders, see the section entitled "Plan of Distribution" on page 19. For a list of the selling stockholders, see the section entitled "Selling Stockholders" on page 17.

        We have agreed to bear all of the expenses incurred in connection with the registration of these shares. The selling stockholders will pay or assume discounts, commissions, fees of underwriters, selling brokers or dealer managers and similar expenses, if any, incurred for the sale of shares of our common stock and/or restricted stock units that may be settled in shares of our common stock.

These securities, which will be issued pursuant to the Senseonics Holdings, Inc. 2023 Commercial Equity Plan, or the Plan, are described in this prospectus. For a more complete description of the plan of distribution of these securities and the Plan, see the sections entitled “Plan of Distribution” and “The Senseonics Holdings, Inc. 2023 Commercial Equity Plan and the Securities We may amend or supplementMay Offer” beginning on page 6 of this prospectus.

The Senseonics board of directors adopted the Plan to provide the ability to grant equity incentive awards to employees of organizations with which we have a commercial arrangement, including our global commercial partner Ascensia Diabetes Care Holdings AG, who assist with the commercialization of our products. The Plan provides for the discretionary granting of nonstatutory stock options and restricted stock units to eligible recipients. The objective of the Plan is to provide award recipients with an opportunity to share in our growth and provide incentives for the participants to exert maximum efforts for our success, further aligning the interests of individuals supporting Eversense commercialization with the interests of our stockholders.
You should carefully read this prospectus from timeand the documents incorporated or deemed to timebe incorporated by filing amendments or supplements as required. You should read the entirereference in this prospectus and any amendments or supplements carefully before you make your investment decision.

purchase any of the securities offered hereby.

Our common stock is listed on the NYSE American and trades under the symbol "SENS."“SENS.” On April 29, 2020,January 10, 2023, the closinglast reported sale price of our common stock on the NYSE American was $0.600$1.05 per share.

        We are a smaller reporting company as defined in Rule 12b-2 promulgated under the Securities Exchange Act of 1934, as amended (the "Exchange Act"). As such, we have elected to rely on certain reduced public company disclosure requirements. See "Implications of Being a Smaller Reporting Company."

Investing in our securities involves risks. Youa high degree of risk. Before making an investment decision, you should review carefully readthe risks and consideruncertainties described under the risk factors included in our periodic reports, in any applicable prospectus supplement relating to a specific offering of securities and in any other documents we file with the Securities and Exchange Commission ("SEC"). See the sections entitled "Risk Factors" belowheading “Risk Factors” on page 13,4 and contained in the documents that are incorporated by reference ininto this prospectus and in the applicable prospectus supplement, if any.prospectus.

Neither the SEC nor any state securities commission has approved or disapproved of these securities, or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES COMMISSION HAS APPROVED OR DISAPPROVED OF THESE SECURITIES OR DETERMINED IF THIS PROSPECTUS IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.

The date of this prospectus is           , 2020.

2023.


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TABLE OF CONTENTS


Page

ABOUT THIS PROSPECTUS

1
2


23

INCORPORATION OF CERTAIN INFORMATION BY REFERENCE


3
4

CAUTIONARY STATEMENT


4

PROSPECTUS SUMMARY

RISK FACTORS


13

USE OF PROCEEDS


165

SELLING STOCKHOLDERS

PLAN OF DISTRIBUTION


195

LEGAL MATTERS


236

EXPERTS


2414
14

i


ABOUT THIS PROSPECTUS

Neither we nor the selling stockholders or the underwriters, if any, have authorized anyone to provide you with any information or to make any representation other than as may be contained in or incorporated by reference into this prospectus, any prospectus supplement or in any free writing prospectus that we may file with the SEC. We do not, and the selling stockholders or the underwriters, if any, do not, take any responsibility for, and can provide no assurances as to, the reliability of any information that others may provide you. This prospectus and any applicable prospectus supplement or free writing prospectus do not constitute an offer to sell any securities in any jurisdiction where such offer and sale are not permitted. The information contained in or incorporated by reference into this prospectus or any prospectus supplement, free writing prospectus or other offering material is accurate only as of the respective dates of those documents or information, regardless of the time of delivery of the documents or information or the time of any sale of the securities. Neither the delivery of this prospectus or any applicable prospectus supplement nor any distribution of securities pursuant to such documents shall, under any circumstances, create any implication that there has been no change in the information set forth in this prospectus or any applicable prospectus supplement or in our affairs since the date of this prospectus or any applicable prospectus supplement.

This prospectus is part of a registration statement that Senseonics Holdings, Inc., or the Company, has filed with the Securities and Exchange Commission, or SEC. Under this registration statement, we may, from time to time, issue any combination of nonstatutory stock options and restricted stock units to eligible participants under the Senseonics Holdings, Inc. 2023 Commercial Equity Plan, which we refer to in this prospectus as the Plan. Senseonics is pleased to provide you with information regarding the Plan. You should carefully read this prospectus together with the additional information described under the heading “Where You Can Find More Information” beginning on page 3 of this prospectus.
The Plan provides you with an opportunity to share in our growth and assists us in providing incentives for participants to exert maximum efforts for the success of Senseonics, further aligning the interests of individuals supporting Eversense commercialization with the interests of Senseonics stockholders. The terms of the Plan provide for the discretionary grant of nonstatutory stock options and restricted stock unit awards to eligible recipients as described in the Plan.
The information appearing in this prospectus is accurate only as of the date on the front of the document and any information we have incorporated by reference is accurate only as of the date of the document incorporated by reference, regardless of the time of delivery of this prospectus or any sale of a security. Our business, financial condition, results of operations and prospects may have changed since those dates.
This prospectus contains summaries of certain provisions contained in some of the documents described herein, but reference is made to the actual documents for complete information. All of the summaries are qualified in their entirety by the actual documents. Copies of some of the documents referred to herein have been filed as exhibits to the registration statement of which this prospectus is a part, and you may obtain copies of those documents as described below under the section entitled “Where You Can Find Additional Information.”

1


PROSPECTUS SUMMARY
About Senseonics
We are a medical technology company focused on the development and manufacturing of glucose monitoring products designed to transform lives in the global diabetes community with differentiated, long-term implantable glucose management technology. Our Eversense E3 continuous glucose monitoring, or CGM, system is designed to continually and accurately measure glucose levels in people with diabetes via an under-the-skin sensor, a removable and rechargeable smart transmitter, and a convenient app for real-time diabetes monitoring and management for a period of up to six months, as compared to seven to 14 days for non-implantable CGM systems. We affixed the CE mark to the original Eversense CGM system in June 2016, which marked the first certification for the product to be sold within the European Economic Area, or the EEA. Subsequently, we affixed the CE mark to the extended life Eversense XL CGM system in September 2017 which was available in select markets in Europe and the Middle East. In June 2022, we affixed the CE mark to the extended life Eversense E3 CGM system and Ascensia began commercialization in select markets in Europe during the third quarter of 2022. In June 2018, the U.S. Food and Drug Administration, or the FDA, approved the Eversense CGM system to be sold throughout the United States. In June 2019, we received FDA approval for the non-adjunctive indication (dosing claim) for the Eversense system. With this approval and the availability of a new app in December 2019, the Eversense system can now be used as a therapeutic CGM in the United States to replace fingerstick blood glucose measurement to make treatment decisions, including insulin dosing. In February 2022, the 180-day extended life Eversense E3 CGM system was approved by the FDA and Ascensia Diabetes Care Holdings AG, or Ascensia, began commercializing Eversense E3 in the United States in the second quarter of 2022.
We are in the early commercialization stages of the Eversense brand and are focused on driving awareness of our CGM system amongst intensively managed patients and their healthcare providers. In both the United States and our overseas markets, we have entered into strategic partnerships and distribution agreements that allow third party collaborators with direct sales forces and established distribution systems to market and promote Senseonics CGM systems, including Eversense, Eversense XL, Eversense E3 and future generation products.
An important part of your participation in the Plan is understanding the Company, our products, operations, and financial condition. You can keep yourself informed about the Company by reviewing proxy statements, reports to stockholders, and other documents that we prepare for our stockholders and the general public. If you become one of our stockholders, you will be entitled to attend our stockholder meetings and to vote in the election of directors and on other matters brought before our stockholders.
Company History
We were originally incorporated as ASN Technologies, Inc. in Nevada on June 26, 2014. On December 7, 2015, we acquired Senseonics, Incorporated, a medical technology company focused on the design, development and commercialization of glucose monitoring systems to improve the lives of people with diabetes by enhancing their ability to manage their disease with relative ease and accuracy (the “Acquisition”).
In connection with the Acquisition, we reincorporated in Delaware and changed our name to Senseonics Holdings, Inc. Upon the closing of the Acquisition, Senseonics, Incorporated merged with a wholly-owned subsidiary of ours formed solely for that purpose and became our wholly-owned subsidiary.
Our principal executive offices are located at 20451 Seneca Meadows Parkway, Germantown, Maryland 20876-7005. Our telephone number is (301) 515-7260. Our website is located at http://www.senseonics.com. The information contained on, or that can be accessed through, our website is not a part of, and should not be construed as being incorporated by reference into, this prospectus.

2


WHERE YOU CAN FIND ADDITIONAL INFORMATION
This prospectus is part of a registration statement on Form S-3 we filed with the SEC utilizing a shelfunder the Securities Act and does not contain all of the information set forth in the registration process or continuous offering process. Under this shelfstatement and the exhibits to the registration process, the selling stockholders may, from timestatement. For further information with respect to time, sellus and the securities described inwe are offering under this prospectus, in one or more offerings. This prospectus provideswe refer you withto the registration statement and the exhibits and schedules filed as a general descriptionpart of the securities that may be offered, from time to time, by the selling stockholders. Each time a selling stockholder sells securities, the selling stockholder may be required to provide you with this prospectus and, in certain cases, a prospectus supplement containing specific information about the selling stockholder and the terms of the securities being offered. That prospectus supplement may include additional risk factors or other special considerations applicable to those securities. Any prospectus supplement may also add, update, or change information in the prospectus. If there is any inconsistency between the information in this prospectus and any prospectus supplement, you should rely on the information in that prospectus supplement.

        You should read this prospectus and any prospectus supplement for a specific offering of securities, together with additional information described in the sections entitled "Where You Can Find More Information" and "Incorporation by Reference" below, before making an investment decision.registration statement. You should rely only on the information contained in this prospectus or incorporated by reference into this prospectus,reference. We have not authorized anyone else to provide you with different information. We are not making an offer of these securities in any accompanying prospectus supplement or any free writing prospectus prepared by or on behalf of us to which we have referred you.

        Unless we state otherwise orwhere the context otherwise requires, references to "Senseonics,"offer is not permitted. You should not assume that the "Company," "us," "we" or "our"information in this prospectus mean Senseonics Holdings, Inc. and, where appropriate, our sole subsidiary. When we refer to "you" inis accurate as of any date other than the date on the front page of this section, we mean all purchasersprospectus, regardless of the time of delivery of this prospectus or any sale of the securities being offered by this prospectusprospectus.

The U.S. federal securities laws require us to provide information about our business and any accompanying prospectus supplement, whether they arefinancial status in our (a) annual reports, filed on a Form 10-K; (b) quarterly reports filed on a Form 10-Q; and (c) current reports relating to important corporate events occurring during the holders or only indirect owners of those securities. We use Senseonics, the Senseonics logo, Eversense and Eversense XL as trademarks in the United States and other countries. All other trademarks or trade names referred to in this prospectus supplement and the accompanying prospectus are the property of their respective owners.


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WHERE YOU CAN FIND MORE INFORMATION

year filed on a Form 8-K. We file annual, quarterly and currentthese reports proxy statements and other information with the SEC.U.S. Securities and Exchange Commission (the “SEC”). We also prepare and file with the SEC a proxy statement in connection with our annual meeting of stockholders. The proxy statement provides further information about us and our officers, non-employee directors, and major stockholders. From time to time we may also file other documents with the SEC as required by Sections 13(a), 13(c), 14 and/or 15(d) of the U.S. Securities Exchange Act of 1934, as amended (the “Exchange Act”). Our SEC filings including the Registration Statement and the exhibits and schedules thereto, are also available to the public fromover the SEC'sInternet at the SEC’s website at http://www.sec.gov. You can also access our SEC filings through our website at

http://senseonics.com. Information contained in or accessible through our website does not constitute a part of this prospectus.


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INCORPORATION OF CERTAIN INFORMATION BY REFERENCE

The SEC allows us to incorporate by reference information into this prospectus, which means that we can disclose important information to you by referring you to another document filed separately with the SEC. The SEC file number for the documents incorporated by reference in this prospectus is 001-37717. The documents incorporated by reference into this prospectus contain important information that you should read about us.

The following documents we have filed or will file with the SEC are incorporated by reference into this document:

    these materials, which constitute the prospectus for the Plan:


our Quarterly Reports on Form 10-Q for the fiscal quarter ended March 31, 2022, filed with the SEC on May 10, 2022, as amendedfor the fiscal quarter ended June 30, 2022, filed with the SEC on April 28, 2020;August 9, 2022, and for the fiscal quarter ended September 30, 2022, filed with the SEC on November 8, 2022;



our Definitive Proxy Statement on Schedule 14A filed with the SEC on April 27, 202015, 2022 to the extent the information in such reports is filed and not furnished;; and


We also incorporate by reference into this prospectus all documents (other than current reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits filed on such form that are related to such items) that are filed by us with the SEC pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act (i) after the date of the initial filing of the registration statement of which this prospectus forms a part and prior to effectiveness of the registration statement, orand (ii) after the date of this prospectus but prior to the terminationfiling of a post-effective amendment that indicates that all securities offered pursuant to the offering.registration statement on Form S-3 we filed with the SEC registering the shares reserved under the Plan have been issued or that deregisters all securities then remaining unissued. These documents include periodic reports, such as Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q and Current Reports on Form 8-K, as well as proxy statements.

        We will provide to each person, including any beneficial owner, to whom a prospectus

A paper copy of these documents is delivered,always available without charge and upon written or oral request a copy of any or all of the documents that are incorporated by reference into this prospectus but not delivered with the prospectus, including exhibits that are specifically incorporated by reference into such documents. You should direct any requests for documentsdirected to our Plan Administrator, at Senseonics Holdings, Inc., Attn: Investor Relations, 2045120415 Seneca Meadows Parkway, Germantown, MD 20876-7005, telephone:20876, telephone (301) 515-7260.

If you are already one of our stockholders, you should


3


receive paper or electronic copies of our proxy statement, reports to stockholders, and other stockholder communications. Alternatively, copies of the most recent reports containing audited financial statements for our most recent fiscal year (which may be the final prospectus by which shares of our common stock are sold to the general public or the annual report to our stockholders) and our other SEC filings are available on the SEC’s website at www.sec.gov.
Any statement contained in this prospectus or contained in a document incorporated or deemed to be incorporated by reference into this prospectus will be deemed to be modified or superseded to the extent that a statement contained in this prospectus or any subsequently filed supplement to this prospectus, or document deemed to be incorporated by reference into this prospectus modifies or supersedes such statement.


RISK FACTORS

Table

Investing in our securities involves a high degree of Contents


CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING STATEMENTS

        This prospectusrisk. Before deciding whether to invest in our securities, you should carefully consider the risks and uncertainties described under the documents incorporated by reference herein contain forward-looking statements. These are based onheading “Risk Factors” contained in our management's current beliefs, expectations and assumptions about future events, conditions and results and on information currently available to us. Discussions containing these forward-looking statements may be found, among other places, in the sections entitled "Business," "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations" incorporated by reference from ourmost recent Annual Report on Form 10-K for the year ended December 31, 2019,and our Current Reportmost recent Quarterly Reports on Form 8-K filed on March 26, 2020,10-Q, as well as any amendments thereto reflected in our subsequent filings with the SEC.

        Any statementsSEC, which are incorporated by reference into this prospectus in their entirety, together with other information in this prospectus orand the documents incorporated herein, about our expectations, beliefs, plans, objectives, assumptions or future events or performanceby reference into this prospectus. The risks described in these documents are not the only ones we face, but those that we consider to be material. There may be other unknown or unpredictable economic, business, competitive, regulatory or other factors that could have material adverse effects on our future results. Past financial performance may not be a reliable indicator of future performance, and historical factstrends should not be used to anticipate results or trends in future periods. If any of these risks actually occurs, our business, financial condition, results of operations or cash flow could be seriously harmed. This could cause the trading price of our common stock to decline, resulting in a loss of all or part of your investment. Please also read carefully the section below entitled “Special Note Regarding Forward-Looking Statements.”

SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS
This prospectus and the documents we have filed with the SEC that are forward-looking statements. Withinincorporated by reference contain “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, or the Securities Act, and Section 21E of the Securities Exchange Act of 1934, as amended, or the Exchange Act, theseAct. These statements relate to future events or to our future operating or financial performance and involve known and unknown risks, uncertainties and other factors which may cause our actual results, performance or achievements to be materially different from any future results, performances or achievements expressed or implied by the forward-looking statements. Forward-looking statements may include, but are not limited to, statements regarding:

    about:
the timing of, and our ability to obtain and maintain regulatory approval of, Eversense XL in the United States;

our ability to maintain regulatory approval and CE Certificates of Eversense in the United States;

our ability to maintain regulatory approvalConformity of Eversense and Eversense XLE3 in Europe;the United States and the EU;

the success of our collaboration and commercialization agreement with Ascensia Diabetes Care Holdings AG, or Ascensia;

the timing of product launches, including Eversense E3;

the clinical utility of Eversense;


our ability to develop future generations of Eversense;


our ability to accessservice our credit facilities in the future;outstanding indebtedness;


our ability to continue as a going concern;

the timing and availability of data from our clinical trials;


the timing of our planned regulatory filings;filings and potential regulatory approvals and CE Certificates of conformity;


our future development priorities;


our ability to obtain adequate reimbursement and third-party payor coverage for Eversense;


our expectations about the willingness of healthcare providers to recommend Eversense to people with diabetes;


our commercialization, marketing and manufacturing capabilities and strategy;

4




our ability to comply with applicable regulatory requirements;


our ability to maintain our intellectual property position;


our estimates regarding the size of, and future growth in, the market for Continuous Glucose Monitoringcontinuous glucose monitoring systems;


our ability to obtain the Stockholder Approval;

the uncertain outcome, impact, timing, effects and results of our exploration of strategic alternatives;

effects of the COVID-19 pandemic;


our estimates regarding the period of time for which our current capital resources will be sufficient to fund our continued operations; and

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    our estimates regarding our future expenses and needs for additional financing.

Discussions containing these forward-looking statements may be found, among other places, in the sections entitled “Business,” “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” incorporated by reference from our most recent Annual Report on Form 10-K or Quarterly Reports on Form 10-Q, as well as any amendments thereto, filed with the SEC. In some cases, you can identify forward-looking statements by the words "may," "might," "can," "will," "toterms such as “may,” “might,” “can,” “will,” “to be," "could," "would," "should," "expect," "intend," "plan," "objective," "anticipate," "believe," "estimate," "predict," "project," "potential," "likely," "continue"” “could,” “would,” “should,” “expect,” “intend,” “plan,” “objective,” “anticipate,” “believe,” “estimate,” “predict,” ���project,” “potential,” “likely,” “continue” and "ongoing,"“ongoing,” or the negative of these terms, or other comparable terminology intended to identify statements about the future, although not all forward-looking statements contain these words.terms. These statements involve knownreflect our current views with respect to future events and unknownare based on assumptions and are subject to risks uncertainties and other factors that may cause our actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements.

        You should refer to the "Risk Factors" section contained in this prospectus and the other documents that are incorporated by reference into this prospectus, for a discussion of important factors that may cause our actual results to differ materially from those expressed or implied by our forward-looking statements.uncertainties. Given these risks, uncertainties, and other factors, many of which are beyond our control, we cannot assure you that the forward-looking statements in this prospectus will prove to be accurate, and you should not place undue reliance on these forward-looking statements. Furthermore, if our

These forward-looking statements prove to be inaccurate, the inaccuracy may be material. In lightrepresent our estimates and assumptions only as of the significant uncertainties in these forward-looking statements, you should not regard these statements as a representation or warranty by us or any other person that we will achieve our objectives and plans in any specified time frame, or at all.

        Except asdate of the document containing the applicable statement. Unless required by law, we assumeundertake no obligation to update these forward-looking statements publicly, or to revise any forward-looking statements to reflect new information or future events or developments occurring after the date of this prospectus, even if new information becomes available in the future.


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PROSPECTUS SUMMARY

This summary highlights selected information contained elsewhere in this prospectus and in the documents we incorporate by reference herein. This summary does not contain all of the informationdevelopments. Thus, you should consider before investingnot assume that our silence over time means that actual events are bearing out as expressed or implied in our common stock.such forward-looking statements. You should read this entire prospectus, carefully, especiallytogether with the risks of investing in our common stock discussed under "Risk Factors" beginning on page 13 of this prospectus and under similar headings in ourAnnual Report on Form 10-K for the year ended December 31, 2019 and ourCurrent Report on Form 8-Kdocuments we have filed on March 26, 2020, as well as any amendments thereto reflected in our subsequent filings with the SEC whichthat are incorporated by reference completely and with the understanding that our actual future results may be materially different from what we expect. We qualify all of the forward-looking statements in the foregoing documents by these cautionary statements.

USE OF PROCEEDS
We will not receive any proceeds from the issuance of the nonstatutory stock options or restricted stock units covered by this prospectus, alongprospectus. However, we may receive proceeds from time to time upon the exercise of nonstatutory stock options we grant under the Plan pursuant to this prospectus. The amount of proceeds that we may receive from the exercise of stock options will depend on the number of stock options we grant under the Plan, the number of such stock options that vest in accordance with our consolidated financial statements and notes to those consolidated financial statementstheir terms and the other information incorporatedextent to which such vested stock options are ultimately exercised by reference in this prospectus, before making an investment decision.

Company Overview

the Plan participants. We are a medical technology company focused on the development and commercialization of a long-term, implantable continuous glucose monitoring, or CGM, system to improve the lives of people with diabetes by enhancing their ability to manage their disease with relative ease and accuracy. Our Eversense and Eversense XL CGM systems are designed to continually and accurately measure glucose levels in people with diabetes via an under-the-skin sensor, a removable and rechargeable smart transmitter, and a convenient app for real-time diabetes monitoring and management for a period of up to 90 and 180 days, respectively, as compared to seven to 14 days for non-implantable CGM systems. We believe that Eversense provides a more convenient method of CGM by providing longer duration, superior accuracy, wireless communication, on-body vibratory alerts, gentle-on-the-skin adhesive patch, data sharing capability, and a removable smart transmitter. The original Eversense CGM system received a CE mark in June 2016, which marked the first approval for the product to be sold within the European Economic Area. Subsequently, the extended life Eversense XL CGM system received its CE mark in September 2017 and is currently available in select markets in Europe, the Middle East, and Africa, or EMEA. In June 2018, the U.S. Food and Drug Administration, or FDA, approved the Eversense CGM system and it is currently available throughout the United States. In June 2019, we received FDA approval for the non-adjunctive indication (dosing claim) for the Eversense system. With this approval and the availability of a new app in December 2019, the Eversense system can now be used as a therapeutic CGM in the United States to replace fingerstick blood glucose measurement to make treatment decisions, including insulin dosing.

        Our focus on the development and approval of the extended life Eversense XL to the U.S. market is ongoing and in September 2019, we completed enrollment of the PROMISE 180-day U.S. pivotal clinical trial of Eversense XL with over 180 subjects enrolled across eight clinical sites. We expect to report topline data from the PROMISE trial in the second quarter of 2020. If the data from the PROMISE trial are positive, we intend to use the data in a regulatory submission to the FDA to expand the Eversense system use for up to 180 days in the United States and expect this approval by the end of 2020. We also intend to use dataproceeds that we receive from the first 90 daysexercise of any stock options for general corporate purposes. Because restricted stock units do not have an associated exercise price, we will not receive any proceeds from the PROMISE trial, if positive, to support a regulatory submission to the FDA for an integrated, or iCGM, designation for our current Eversense 90-day system, which the FDA could potentially approve in the second halfsettlement of 2020. This would allow Eversense to integrate with other compatible medical devices and electronic interfaces, such as automated insulin dosing systems, insulin pumps, and blood glucose meters.


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Recent Developments

Solar Capital Limited

        On March 23, 2020, we announcedrestricted stock units that it was undertaking a strategic review following its inability to obtain a waiver of a covenant default from its senior lender, Solar Capital Limited, which resulted in the Company repaying all amounts outstanding under the credit facility with Solar Capital.

Strategic Review and Evaluation of Strategic Alternatives

        In light of the repayment of amounts outstanding under the Solar Capital credit facility and to provide us with stability, we undertook to secure financing to provide sufficient funding flexibility to enable the Board to complete its strategic review and provide us stability. The strategic alternatives could include a sale of the Company, although there can be no assurance that we pursue any particular action or transaction; however, we intend to assess all viable paths to enhancing stakeholder value.

        On March 26, 2020, we announced that, as part of its strategic review, we have determined to focus our operations on the core activities required to ensure the long-term success of the Eversense® CGM System. We believe that this will allow reductions in our cost structure and improvements in our operating cash flow, in addition to generating future capital expenditure savings. As part of the strategic review, and considering the impact of the COVID-19 global pandemic on access to physician offices and medical facilities, we suspended commercial sales in the United States of our 90-day Eversense CGM system to new patients and physician practices. We intend to continue distributing the 90-day Eversense system to patients who are currently using the product for the foreseeable future. We also intend to continue supporting existing patients and their physicians. We are evaluating its Eversense Bridge program and may revise, suspend or cancel this program in its entirety.

        We plan to continue our development and regulatory submission efforts for its Eversense XL CGM system for use for up to 180 days in the United States as disclosed in the our Annual Report on Form 10-K for the year ended December 31, 2019.

Loan Facility with Highbridge

        On April 21, 2020, we, and Senseonics, Incorporated, our wholly-owned subsidiary, entered into a Loan and Security Agreement (the "Highbridge Loan Agreement") with certain funds managed by Highbridge Capital Management, LLC ("Highbridge"), as the lenders (together with the other lenders from time to time party thereto, the "Lenders") and Wilmington Savings Fund Society, SCB, as collateral agent.

        Pursuant to the Highbridge Loan Agreement, we may borrow up to an aggregate of $20.0 million in aggregate principal through the issuance and sale of First Lien Secured Notes due October 2021 (the "First Lien Term Notes"). The first tranche of borrowing, in which we issued and sold First Lien Term Notes in the aggregate principal amount of $15.0 million, occurred on April 24, 2020 (the "Closing Date"). Under the terms of the Highbridge Loan Agreement, we may issue upunder the Plan.

PLAN OF DISTRIBUTION
The stock options and restricted stock units, and the common stock issuable upon exercise and/or settlement of these awards will be issued directly to an additional $5.0 million in aggregate principal amountthe Plan participants, without the use of First Lien Term Notes in a subsequent closing, conditioned uponunderwriters, brokers or dealers. Our Compensation Committee will determine the effectivenessaward recipients, who will be eligible participants under the Senseonics Holdings, Inc. 2023 Commercial Equity Plan. The purpose of this registration statement. Indistribution is to incentivize the award recipients to exert maximum efforts in fulfillment of their responsibilities to their employer in connection with the Highbridge Loan Agreement, we also issued 1,500,000commercialization of the Company’s products pursuant to commercial arrangements between Senseonics and their employer, by providing the award recipients a means to benefit from increases in the value of shares of common stock of the Company, $0.001 par value per share ("Common Stock") tofurther aligning the Lenders asinterests of individuals supporting Eversense commercialization with the interests of Senseonics stockholders.

5


THE SENSEONICS HOLDINGS, INC. 2023 COMMERCIAL EQUITY PLAN AND THE
SECURITIES WE MAY OFFER
Below is a commitment fee (the "Commitment Fee Shares") on the Closing Date. We expect to use the proceedsdiscussion of the First Lien Term Notes for working capital and general corporate purposes.

        The First Lien Term Notes are our secured, senior obligations. Interest in cash at the annual rate of 12% or, at our option, payment in kind at an annual rate of 13%, on the First Lien Term Notes will be payable monthly in arrears. The maturity date for the First Lien Term Notes will be October 24, 2021 (the "First Lien Maturity Date"), unless earlier repurchased, redeemed or converted in accordance


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with their terms. The obligations under the First Lien Term Notes are secured by substantially all our assets and those of our subsidiary, Senseonics, Incorporated.

        We have the right to prepay the First Lien Term Notes at any time, subject to a prepayment premium, which in certain circumstances we may elect to pay in Common Stock, equal to the aggregate amount of interest payments through maturity. However, if the date of payment in cash of such prepayment premium is on or before August 22, 2020, the prepayment premium will be reduced by 25%.

        Subject to certain conditions, if we retain or reinvest proceeds of an asset sale pursuant to the asset sale prepayment provisions in the Highbridge Loan Agreement, the Lenders shall be entitled to convert First Lien Term Notes and Holders (defined below) shall be entitled to convert Second Lien Notes in aggregate combined principal amount equal to 45% of such net proceeds retained or reinvested (together with any applicable prepayment premium) to Common Stock at a price per share equal to 90% of the greater of (i) the daily volume weighted average of the price per share of the Common Stock, on the conversion date, or if the conversion date is not a trading date, the trading day immediately prior to the conversion date and (ii) $0.57 per share. This conversion option has a daily limit of $1,000,000 in aggregate converted principal (inclusive of principal amount of Second Lien Notes (as defined below) that are voluntarily converted by the Holders (as defined below)).

        From and after a Strategic Transaction Announcement (as defined in the form of First Lien Term Note), we may elect to convert up to $9,375,000 (or $12,500,000 if the additional $5.0 million is funded) in aggregate principal of the First Lien Term Notes to Common Stock at a price per share equal to 90% of the greater of (i) the daily volume weighted average of the price per share of the Common Stock, on the conversion date, or if the conversion date is not a trading date, the trading day immediately prior to the conversion date and (ii) $0.57 per share of Common Stock. This conversion option has a daily limit of $300,000 in aggregate converted principal. If we or the Lenders elect to convert any of the First Lien Term Notes, the amount converted will be equal to the principal and unpaid accrued interest plus the applicable prepayment premium.

        The Highbridge Loan Agreement contains customary terms and covenants, including without limitation: financial covenants, such as operating within an approved budget and maintaining a minimum cash balance; and negative covenants, such as limitations on indebtedness, liens, mergers, asset transfers, certain investing activities and other matters customarily restricted in such agreements. Most of these restrictions are subject to certain minimum thresholds and exceptions. The Highbridge Loan Agreement also contains customary events of default, after which the First Lien Term Notes may be due and payable immediately, including, without limitation, payment defaults, material inaccuracy of representations and warranties, covenant defaults, material adverse changes, bankruptcy and insolvency proceedings, cross-defaults to certain other agreements, judgments against us, and change of control, termination of any guaranty, governmental approvals, and lien priority.

Exchange Agreement with Highbridge

        In addition, on April 21, 2020 we entered into a Note Purchase and Exchange Agreement (the "Exchange Agreement") with certain funds managed by Highbridge providing for the exchange (the "Exchange") of $24.0 million aggregate principal amount of our outstanding 5.25% Senior Convertible Notes due 2025 (the "2025 Notes") for (i) $15,675,000 aggregate principal amount of newly issued Second Lien Secured Notes due January 2022 (the "Second Lien Notes" and, together with the First Lien Term Notes, the "Senior Notes"), (ii) 11,026,086 shares of Common Stock, (iii) warrants (the "Warrants") to purchase up to 4,500,000 shares of Common Stock at an exercise price of $0.66 per share, and (iv) $346,500 in accrued and unpaid interest on the 2025 Notes being exchanged. The Exchange closed on April 24, 2020. The Warrants may be exercised in cash or on a cashless basis at any time through the three year anniversary of the issuance date.


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        The Second Lien Notes are our secured, senior obligations, junior only to the First Lien Term Notes. Interest in cash at the annual rate of 7.5% or, at our option, payment in kind at an annual rate of 8.25%, on the Second Lien Notes will be payable monthly in arrears. The maturity date for the Second Lien Notes will be January 24, 2022 (the "Second Lien Maturity Date"), unless earlier repurchased, redeemed or converted in accordance with their terms. The obligations under the Second Lien Notes are secured by substantially all of our assets and those of our subsidiary, Senseonics, Incorporated.

        We have the right to prepay the Second Lien Notes at any time, subject to a prepayment premium, which in certain circumstances we may elect to pay in Common Stock, equal to the aggregate amount of interest payments through maturity. However, if the date of payment in cash of such prepayment premium is on or before August 22, 2020, the prepayment premium will be reduced by 25%.

        The holders of the Second Lien Notes (the "Holders") will have the right to convert up to $7,000,000 aggregate principal of the Second Lien Notes (together with any applicable prepayment premium) to Common Stock at a price per share equal to 90% of the greater of (i) the daily volume weighted average of the price per share of the Common Stock, on the conversion date, or if the conversion date is not a trading date, the trading day immediately prior to the conversion date and (ii) $0.57 per share. This conversion option has a daily limit of $1,000,000 in aggregate converted principal (inclusive of principal amount of First Lien Term Notes that are voluntarily converted by the Lenders). Subject to certain conditions, if we retain or reinvest proceeds of an asset sale pursuant to the asset sale prepayment provisions in the Exchange Agreement, the Holders shall be entitled to convert additional Second Lien Notes and the Lenders shall be entitled to convert First Lien Term Notes in aggregate combined principal amount equal to 45% of such net proceeds retained or reinvested (together with any applicable prepayment premium).

        From and after a Strategic Transaction Announcement, we may elect to convert up to $8,675,000 in aggregate principal of the Second Lien Notes to Common Stock at a price per share equal to 90% of the greater of (i) the daily volume weighted average of the price per share of the Common Stock, on the conversion date, or if the conversion date is not a trading date, the trading day immediately prior to the conversion date and (ii) $0.57 per share. This conversion option has a daily limit of $300,000 in aggregate converted principal. If we or the Holders elect to convert any of the Second Lien Notes, the amount converted will be equal to the principal and unpaid accrued interest plus the applicable premium.

        The Exchange Agreement contains customary terms and covenants, including without limitation: financial covenants, such as maintaining a minimum cash balance; and negative covenants, such as limitations on indebtedness, liens, mergers, asset transfers, certain investing activities and other matters customarily restricted in such agreements. Most of these restrictions are subject to certain minimum thresholds and exceptions. The Exchange Agreement also contains customary events of default, after which the Second Lien Notes may be due and payable immediately, without limitation, payment defaults, material inaccuracy of representations and warranties, covenant defaults, material adverse changes, bankruptcy and insolvency proceedings, cross-defaults to certain other agreements, judgments against us, and change of control, termination of any guaranty, governmental approvals, and lien priority.

Payroll Protection Program

        On April 22, 2020, Senseonics, Incorporated, our wholly-owned subsidiary, received $5.8 million in loan funding from the Paycheck Protection Program (the "PPP"), established pursuant to the recently enacted Coronavirus Aid, Relief, and Economic Security Act (the "CARES Act") and administered by the U.S. Small Business Administration ("SBA"). The unsecured loan (the "PPP Loan") is evidenced


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by a promissory note of the Company dated April 21, 2020 (the "Note") in the principal amount of $5.8 million with Silicon Valley Bank (the "Bank"), the lender.

        Under the terms of the NotePlan and the PPP Loan, interest accrues on the outstanding principal at the rate of 1.0% per annum. The term of the Note is two years, though it may be payable sooner in connection with an event of default under the Note. To the extent the loan amount is not forgiven under the PPP, we are obligated to make equal monthly payments of principalnonstatutory stock options and interest, beginning seven months from the date of the Note, until the maturity date.

        The CARES Act and the PPP provide a mechanism for forgiveness of up to the full amount borrowed. Under the PPP, we may apply for forgiveness for all or a part of the PPP Loan. The amount of loan proceeds eligible for forgiveness is based on a formula that takes into account a number of factors, including the amount of loan proceeds used by us during the eight-week period after the loan origination for certain purposes including payroll costs, interest on certain mortgage obligations, rent payments on certain leases, and certain qualified utility payments, provided that at least 75% of the loan amount is used for eligible payroll costs; the employer maintaining or rehiring employees and maintaining salaries at certain levels; and other factors. Subject to the other requirements and limitations on loan forgiveness, only loan proceeds spent on payroll and other eligible costs during the covered eight-week period will qualify for forgiveness. We intend to use the entire Loan amount for qualifying expenses, though no assurance is provided that we will obtain forgiveness of the PPP Loan in whole or in part.

        The Note may be prepaid in part or in full, at any time, without penalty. The Note provides for certain customary events of default, including (i) failing to make a payment when due under the Note, (ii) failure to do anything required by the Note or any other loan document, (iii) defaults of any other loan with the Bank, (iv) failure to disclose any material fact or make a materially false or misleading representation to the Bank or SBA, (v) default on any loan or agreement with another creditor, if the Bank believes the default may materially affect our ability to pay the Note, (vi) failure to pay any taxes when due, (vii) becoming the subject of a proceeding under any bankruptcy or insolvency law, having a receiver or liquidator appointed for any part of our business or property, or making an assignment for the benefit of creditors, (viii) having any adverse change in financial condition or business operation that the Bank believes may materially affect our ability to pay the Note, (ix) if we reorganize, merge, consolidate, or otherwise changes ownership or business structure without the Bank's prior written consent, or (x) become the subject of a civil or criminal action that the Bank believes may materially affect our ability to pay the Note. Upon the occurrence of an event of default, the Bank has customary remedies and may, among other things, require immediate payment of all amounts owed under the Note, collect all amounts owing from us, and file suit and obtain judgment against us.

Company Information

        We were originally incorporated as ASN Technologies, Inc. in Nevada on June 26, 2014. On December 7, 2015, we acquired Senseonics, Incorporated, a medical technology company focused on the design, development and commercialization of glucose monitoring systems to improve the lives of people with diabetes by enhancing their ability to manage their disease with relative ease and accuracy (the "Acquisition").

        In connection with the Acquisition, we reincorporated in Delaware and changed our name to Senseonics Holdings, Inc. Upon the closing of the Acquisition, Senseonics, Incorporated merged with a wholly-owned subsidiary of ours formed solely for that purpose and became our wholly-owned subsidiary.

        Our principal executive offices are located at 20451 Seneca Meadows Parkway, Germantown, Maryland 20876-7005. Our telephone number is (301) 515-7260. Our website is located at


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http://www.senseonics.com. We do not incorporate by reference into this prospectus the information on, or accessible through, our website, and you should not consider it as part of this prospectus.

Implications of Being a Smaller Reporting Company

        We are a "smaller reporting company" as defined in Rule 12b-2 promulgated under the Exchange Act. We may remain a smaller reporting company until we have a non-affiliate public float in excess of $250 million and annual revenues in excess of $100 million, or a non-affiliate public float in excess of $700 million, each as determined on an annual basis. A smaller reporting company may take advantage of relief from some of the reporting requirements and other burdens that are otherwise applicable generally to public companies. These provisions include:

    being permitted to provide only two years of audited financial statements, in addition to any required unaudited interim financial statements, with correspondingly reduced "Management's Discussion and Analysis of Financial Condition and Results of Operations" disclosure;

    not being required to comply with the auditor attestation requirements in the assessment of our internal control over financial reporting (beginning with the fiscal year ending December 31, 2020); and

    reduced disclosure obligations regarding executive compensation in our periodic reports, proxy statements and registration statements.

        To the extent that we take advantage of these reduced burdens, the information that we provide stockholders may be different than you might obtain from other public companies in which you hold equity interests.


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The Offering

Common stock offered by the selling stockholders

53,330,885 shares

Terms of the offering

The selling stockholders, including their transferees, donees, pledgees or successors-in-interest, may sell, transfer or otherwise dispose of any or all of the shares of common stock offered by this prospectus from time to time on the NYSE American or any other stock exchange, market or trading facility on which the shares are traded or in private transactions. The shares of common stock may be sold at fixed prices, at prevailing market prices, at prices related to prevailing market prices or at negotiated prices. See "Plan of Distribution" on page 19.

Use of proceeds

We will not receive any proceeds from the sale of the shares of common stock covered by this prospectus.

Risk factors

See "Risk Factors" beginning on page 13, for a discussion of factors you should carefully consider before deciding to invest in our common stock.

NYSE American symbol

SENS


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RISK FACTORS

        Investing in our commonrestricted stock involves risks. You should carefully consider the risk factors described below, as well as the risk factors described in Part I, Item 1A, "Risk Factors" in ourAnnual Report on Form 10-K for the fiscal year ended December 31, 2019, ourCurrent Report on Form 8-K filed on March 26, 2020, and any updates to those risk factors or new risk factors contained in our subsequent Quarterly Reports on Form 10-Q, all of which is incorporated by reference into this prospectus, as the same may be amended, supplemented or superseded from time to time by our filings under the Exchange Act, as well as any prospectus supplement relating to a specific offering or resale. Before making any investment decision, you should carefully consider these risks as well as other information we include or incorporate by reference in this prospectus or in any applicable prospectus supplement or free writing prospectus. For more information, see the sections entitled "Where You Can Find More Information" and "Incorporation by Reference" above. These risks could materially affect our business, results of operations or financial condition and affect the value of our common stock. You could lose all or part of your investment. Additionally, the risks and uncertainties discussed in this prospectus or in any document incorporated by reference into this prospectus are not the only risks and uncertainties that we face, and additional risks and uncertainties not presently known to us or that we currently deem immaterial may also affect our business, results of operations or financial condition.

Restrictive covenants under the indentures related to 5.25% convertible senior subordinated notes due 2023 and the 5.25% convertible senior notes due 2025, the Highbridge Loan Agreement and the Exchange Agreement may limit the manner in which we operate.

        The indentures related to 5.25% convertible senior subordinated notes due 2023 (the "2023 Notes") and the 5.25% convertible senior notes due 2025 (the "2025 Notes"), the Exchange Agreement, and the Highbridge Loan Agreement contain, and any future indebtedness we incur may contain, various negative covenants that restrict, among other things, our ability to:

    incur additional indebtedness, guarantee indebtedness or issue disqualified stock or, in the case of such subsidiaries, preferred stock;

    declare or pay dividends on, repurchase or make distributions in respect of, their capital stock or make other restricted payments;

    make investments or acquisitions;

    create liens;

    enter into agreements restricting certain subsidiaries' ability to pay dividends or make other intercompany transfers;

    consolidate, merge, sell or otherwise dispose of all or substantially all of our assets and the assets of our restricted subsidiaries;

    enter into transactions with affiliates;

    sell, transfer or otherwise convey certain assets; and

    prepay certain types of indebtedness.

        In addition, the Highbridge Loan Agreement and the Exchange Agreement have minimum liquidity requirements and the Highbridge Loan Agreement includes a covenant requiring the Company to operate within an approved budget. Our obligations under both the Highbridge Loan Agreement and the Exchange Agreement are secured by substantially all of our assets. As a result, we are limited


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in the manner in which we conduct our business and we may be unable to engage in favorable business activities, repurchase shares of our common stock or finance future operations or capital needs.

Servicing our debt requires a significant amount of cash, and we may not have sufficient cash flow from our business to pay our substantial debt.

        Our ability to make scheduled payments of the principal of, to pay interest on or to refinance our indebtedness depends on our future performance, which is subject to economic, financial, competitive and other factors beyond our control, including uncertainties related to the COVID-19 pandemic. Our business may not generate cash flow from operations in the future sufficient to service our debt and make necessary capital expenditures. If we are unable to generate such cash flow, we may be required to adopt one or more alternatives, such as selling assets, restructuring debt or obtaining additional equity capital on terms that may be onerous or highly dilutive. Our ability to refinance our indebtedness will depend on the capital markets and our financial condition at such time. We may not be able to engage in any of these activities or engage in these activities on desirable terms, which could result in a default on our debt obligations.

Despite our current debt levels, subject to certain conditions and limitations, we may still incur substantially more debt or take other actions which would intensify the risks discussed above.

        Despite our current consolidated debt levels, subject to certain conditions and limitations in the indentures related to the 2023 Notes and the 2025 Notes, the Highbridge Loan Agreement and the Exchange Agreement, we may be able to incur substantial additional debt in the future, some of which may be secured debt. We may not be subject to any restrictions on incurrence of additional indebtedness under the terms of any future indebtedness. If new debt is added to our current debt levels, the related risks that we and they now face could intensify.

The issuance of additional stock in connection with financings, acquisitions, investments, our stock incentive plan, upon the conversion of our convertible senior subordinated notes or otherwise will dilute our existing stockholders.

        Our certificate of incorporation authorizes us to issue up to 450,000,000 shares of common stock and up to 5,000,000 shares of preferred stock with such rights and preferences as may be determined by our board of directors. Subject to compliance with applicable rules and regulations, we may issue our shares of common stock, including by conversion of our convertible notes, in certain circumstances, in connection with a financing, acquisition, investment, our equity incentive plans or otherwise. Any such issuance could result in substantial dilution to our existing stockholders and cause the trading price of our common stock to decline.

We may not be entitled to forgiveness of our recently received PPP Loan, and our application for the PPP Loan could in the future be determined to have been impermissible or could result in damage to our reputation.

        On April 22, 2020 we received proceeds of $5.8 million from a loan under the Paycheck Protection Program of the CARES Act, a portion of which may be forgiven, which we intend to use to retain current employees, maintain payroll and make lease and utility payments. The PPP Loan matures on April 21, 2022 and bears annual interest at a rate of 1.0%. Commencing November 21, 2020, we are required to pay the lender equal monthly payments of principal and interest as required to fully amortize by April 21, 2022 any principal amount outstanding on the PPP Loan as of October 21, 2020. A portion of the PPP Loan may be forgiven by the SBA upon our application beginning 60 days but not later than 120 days after loan approval and upon documentation of expenditures in accordance with the SBA requirements. Under the CARES Act, loan forgiveness is available for the sum of documented payroll costs, covered rent payments, covered mortgage interest and covered utilities during the eight


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week period beginning on the date of loan approval. Not more than 25% of the forgiven amount may be for non-payroll costs. The amount of the PPP Loan eligible to be forgiven is limited because of certain headcount reductions that we implemented in March 2020 and will be reduced if our full-time headcount declines further, or if salaries and wages for employees with salaries of $100,000 or less annually are reduced by more than 25%. We will be required to repay any portion of the outstanding principal that is not forgiven, along with accrued interest, in accordance with the amortization schedule described above, and we cannot provide any assurance that we will be eligible for loan forgiveness, that we will ultimately apply for forgiveness, or that any amount of the PPP Loan will ultimately be forgiven by the SBA. Furthermore, on April 28, 2020, the Secretary of the U.S. Department of the Treasury stated that the SBA will perform a full review of any PPP loan over $2.0 million before forgiving the loan.

        In order to apply for the PPP Loan, we were required to certify, among other things, that the current economic uncertainty made the PPP Loan request necessary to support our ongoing operations. We made this certification in good faith after analyzing, among other things, our financial situation and access to alternative forms of capital, and believe that we satisfied all eligibility criteria for the PPP Loan, and that our receipt of the PPP Loan is consistent with the broad objectives of the Paycheck Protection Program of the CARES Act. The certification described above does not contain any objective criteria and is subject to interpretation. On April 23, 2020, the SBA issued guidance stating that it is unlikely that a public company with substantial market value and access to capital markets will be able to make the required certification in good faith. The lack of clarity regarding loan eligibility under the Paycheck Protection Program has resulted in significant media coverage and controversy with respect to public companies applying for and receiving loans. If, despite our good-faith belief that given our Company's circumstances we satisfied all eligible requirements for the PPP Loan, we are later determined to have violated any of the laws or governmental regulations that apply to us in connection with the PPP Loan, such as the False Claims Act, or it is otherwise determined that we were ineligible to receive the PPP Loan, we may be subject to penalties, including significant civil, criminal and administrative penalties and could be required to repay the PPP Loan in its entirety. In addition, receipt of a PPP Loan may result in adverse publicity and damage to reputation, and a review or audit by the SBA or other government entity or claims under the False Claims Act could consume significant financial and management resources. Any of these events could have a material adverse effect on our business, results of operations and financial condition.


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USE OF PROCEEDS

        The selling stockholders will receive all of the proceeds from their sale from time to time under this prospectus and any accompanying prospectus supplement of the common stock described herein. We will not receive any proceeds from these sales.


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SELLING STOCKHOLDERS

        The shares of common stock being offered by the selling stockholders are those issuable to the selling stockholders upon conversion of the First Lien Term Notes, shares of common stock issued as a commitment fee in connection with the First Lien Term Notes financing and shares issuable upon exercise of warrants that we issued in a concurrent transaction. For additional information regarding the issuance of the First Lien Term Notes, commitment fee shares and warrants, see "Recent Developments—Loan Facility with Highbridge" and "Recent Developments—Exchange Agreement with Highbridge" above. We are registering the shares of common stock in order to permit the selling stockholders to offer the shares for resale from time to time.

        The table below lists the selling stockholders and other information regarding the beneficial ownership of the shares of common stock by each of the selling stockholders. The second column lists the number of shares of common stock beneficially owned by each selling stockholder, based on its ownership of the shares of common stock, First Lien Term Notes, Second Lien Notes and Warrants, as of April 24, 2020, assuming full conversion of the First Lien Term Notes and Second Lien Notes and full exercise of the Warrants held by the selling stockholders on that date, after taking into account contractual limitations on conversion or exercise on the selling stockholder, and without regard to the limitations on the number of shares of common stockunits that we may issue upon conversion of the First Lien Term Notes and Second Lien Notes pursuant to NYSE American listing standards without the approval of our stockholders.

        In accordance with the terms of registration rights agreements with the selling stockholders, this prospectus generally covers the resale of that number of shares of common stock equal to the number of shares of common stock issuable upon conversion of the First Lien Term Notes, determined as if the First Lien Term Notes were converted in full (including the interest make-whole payment that would apply if the conversion had occurred on such date), in each case as of the trading day immediately preceding the date this registration statement was initially filed with the SEC. Notwithstanding the foregoing, the maximum number of shares that may be resold under this prospectus is limited unless and until our stockholders approve the issuance of a greater number of shares in accordance with NYSE American listing standards.

        For purposes of this prospectus, "selling stockholders" includes the stockholders listed below and their permitted pledgees, donees, transferees or successors-in-interest who may acquire securities through a pledge, gift, partnership distribution or other non-sale related transfer from the selling stockholders. Our registration of the resale of the shares of common stock, including common stock issuable upon conversion of the notes and upon exercise of the warrants, does not necessarily mean that the selling stockholders will sell all or any of such common stock. The following table sets forth certain information as of April 24, 2020 concerning the shares of common stock that may be offered from time to time by each selling stockholder with this prospectus. The information is based on information provided by or on behalf of the selling stockholders. Information about the selling stockholders may change over time. Any changed or new information given to us by the selling stockholders will be set forth in supplements to this prospectus or amendments to the registration statement of which this prospectus is a part, if and when necessary.

 
 Shares Beneficially Owned
Prior to the Offering
 Number of
Shares
Being
Offered
for Resale
 Shares Beneficially
Owned After the Offering
 
Name and Address of Selling Stockholder
 Shares Percentage(1) Shares(2) Percentage(1) 

Highbridge Tactical Credit Master Fund, L.P.(3)

  22,450,000(4) 9.9% 50,740,637(5) 25,920,552  9.7%

*
Less than 1%

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(1)
The percentage is based on 217,071,667 shares of common stock outstanding as of April 28, 2020, adjusted in accordance with Rule 13d-3 under the Exchange Act.

(2)
Assumes the sale of all shares offered pursuant to this prospectus and treats all such shares as outstanding for the purpose of calculating the beneficial ownership percentage.

(3)
Highbridge Capital Management, LLC ("HCM") is the trading manager of Highbridge Tactical Credit Master Fund, L.P. The address of HCM is 277 Park Avenue, 23rd Floor, New York, NY 10172, and the address of Highbridge Tactical Credit Master Fund, L.P. is c/o Maples Corporate Services Limited, PO Box 309, Ugland House, South Church Street, George Town, Grand Cayman KY1-1104, Cayman Islands.

(4)
This represents the number of shares of common stock equal to 9.9% of the total shares of common stock outstanding if the selling stockholder converted the maximum number of securities permitted by the conversion caps discussed in further detail below. Without giving effect to the conversion limitation, the number of shares included in this column would consist of (i) 12,526,086 shares of common stock, (ii) 4,500,000 shares underlying currently exercisable warrants to purchase common stock, and (iii) 14,894,466 shares of common stock issuable upon conversion of Second Lien Notes, based on a conversion price as of April 28, 2020 of $0.543 per share, which represents a 10% discount to the daily volume weighted average price of the common stock on April 28, 2020 and excludes an aggregate of 18,458,499 shares of common stock issuable upon conversion of Second Lien Notes, based on a conversion price as of April 28, 2020 of $0.543 per share, which represents a 10% discount to the daily volume weighted average price of the common stock on April 28, 2020, as such conversion rights are not exercisable by the selling stockholder within sixty days of April 28, 2020 or exercisability is outside the control of the selling stockholder as of April 28, 2020. Excludes an aggregate of 44,740,637 shares of common stock issuable upon conversion of First Lien Term Notes, based on a conversion price as of April 28, 2020 of $0.543 per share, which represents a 10% discount to the daily volume weighted average price of the common stock on April 28, 2020, as such conversion rights are not exercisable by the selling stockholder within sixty days of April 28, 2020 or exercisability is outside of the control of the selling stockholder as of April 28, 2020. In addition, pursuant to terms of the Warrants, First Lien Term Notes and Second Lien Notes, such instruments are not exercisable or convertible to the extent that, upon such conversion or exercise, the number of shares of common stock then beneficially owned by the selling stockholder and its affiliates and any other persons or entities whose beneficial ownership of common stock would be aggregated with such selling stockholder's for purposes of Section 13(d) of the Exchange Act (including shares held by any "group" of which such stockholder is a member) would exceed 9.90% of the total number of shares of common stock then issued and outstanding.

(5)
Consists of (i) 1,500,000 shares of common stock, (ii) 4,500,000 shares underlying warrants to purchase common stock, and (iii) 44,740,637 shares of common stock issuable upon conversion of the First Lien Term Notes, based on a conversion price as of April 28, 2020 of $0.543 per share, which represents a 10% discount to the daily volume weighted average price of the common stock on April 28, 2020.

        Except for the transactions referred to herein and in documents filed by us with the SEC pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act, none of the selling stockholders has, or within the last three years has had, any position, office or other material relationship (legal or otherwise) with us or any of our subsidiaries other than as a holder of our securities.


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PLAN OF DISTRIBUTION

        We are registering the common stock of the Company (the "Securities") covered by this prospectus on behalf of the Selling Stockholders. All costs, expenses and fees connected with the registration of these Securities will be borne by us. Any brokerage commissions and similar expenses connected with selling the Securities will be borne by the Selling Stockholders. The Selling Stockholders may offer and sell the Securities covered by this prospectus from time to time in one or more transactions. The term "Selling Stockholders" includes pledgees, donees, transferees and other successors-in-interest who may acquire Securities through a pledge, gift, partnership distribution or other non-sale related transfer from the Selling Stockholders. The Selling Stockholders will act independently of the Company in making decisions with respect to the timing, manner and size of each sale. These transactions include:

    through one or more underwriters or dealers in a public offering and sale by them, whether individually or through an underwriting syndicate led by one or more managing underwriters;

    in "at the market offerings" within the meaning of Rule 415(a)(4) under the Securities Act, to or through a market maker or into an existing trading market, on an exchange or otherwise;

    directly to a limited number of purchasers or to a single purchaser;

    through agents;

    by delayed delivery contracts or by remarketing firms;

    ordinary brokerage transactions and transactions in which the broker solicits purchasers;

    purchases by a broker-dealer as principal and resale by the broker-dealer for its own account pursuant to this prospectus;

    exchange or over-the-counter distributions in accordance with the rules of the exchange or other market;

    block trades in which the broker-dealer attempts to sell the Securities as agent but may position and resell a portion of the block as principal to facilitate the transaction;

    transactions in options, swaps or other derivatives that may or may not be listed on an exchange;

    a combination of any such method of sale; or

    any other method permitted pursuant to applicable law.

        In connection with distributions of the Securities or otherwise, the Selling Stockholders may:

    sell the Securities:

    in negotiated transactions;

    in one or more transactions at a fixed price or prices, which may be changed from time to time;

    at market prices prevailing at the times of sale;

    at prices related to such prevailing market prices; or

    at negotiated prices;

    sell the Securities:

    on a national securities exchange;

    in the over-the-counter market; or

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      in transactions otherwise than on an exchange or in the over-the-counter market, or in combination;

    sell the Securities short and/or deliver the Securities to close out short positions;

    enter into option or other transactions with broker-dealers or other financial institutions which require the delivery to them of Securities covered by this prospectus, which they may in turn resell; and

    pledge Securities to broker-dealers or other financial institutions, which, upon a default, they may in turn resell.

        The Selling Stockholders may also resell all or a portion of the Securities in open market transactions in reliance upon Rule 144 under the Securities Act of 1933, as amended, or the Securities Act, as permitted by that rule, Section 4(a)(1) under the Securities Act, if available, or any other exemption from the registration requirements that become available, rather than under this prospectus.

        If underwriters are used in the sale of any Securities, such Securities will be acquired by the underwriters for their own account and may be resold from time to time in one or more transactions described above. Securities may be either offered to the public through underwriting syndicates represented by managing underwriters or directly by underwriters. We may use underwriters with whom we have a material relationship. As applicable, we will describe in each accompanying prospectus supplement the name of the underwriter(s) and the nature of any such relationship(s).

        If a dealer is used in an offering of Securities, the dealer may purchase the securities, as principal. The dealer may then resell the Securities to the public at varying prices to be determined by the dealer at the time of sale.

        Securities may be sold directly or through agents designated from time to time. We will name any agent involved in the offering and sale of such shares and we will describe any commissions paid to the agent in the prospectus supplement. Unless the prospectus supplement states otherwise, the agent will act on a best-efforts basis for the period of its appointment.

        Underwriters, dealers and agents may be entitled to indemnification by us against certain civil liabilities, including liabilities under the Securities Act, or to contribution with respect to payments made by the underwriters, dealers or agents, under agreements between us and the underwriters, dealers and agents.

        Underwriters who participate in the distribution of Securities may be granted an option to purchase additional Securities in connection with the distribution.

        Underwriters, dealers or agents may receive compensation in the form of discounts, concessions or commissions from us or our purchasers, as their agents in connection with the sale of securities. These underwriters, dealers or agents may be considered to be underwriters under the Securities Act. As a result, discounts, commissions or profits on resale received by the underwriters, dealers or agents may be treated as underwriting discounts and commissions. Each accompanying prospectus supplement will identify any such underwriter, dealer or agent and describe any compensation received by them from us. Any initial public offering price and any discounts or concessions allowed or re-allowed or paid to dealers may be changed from time to time.

        In connection with sales of Securities, the Selling Stockholders may enter into hedging transactions with broker-dealers or other financial institutions, which may in turn engage in short sales of Securities in the course of hedging in positions they assume. The Selling Stockholders may also sell Securities short and the Selling Stockholders may deliver Securities covered by this prospectus to close out short positions and to return borrowed Securities in connection with such short sales. The Selling Stockholders may also loan or pledge Securities to broker-dealers that in turn may sell such Securities,


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to the extent permitted by applicable law. The Selling Stockholders may also enter into option or other transactions with broker-dealers or other financial institutions or the creation of one or more derivative securities which require the delivery to such broker-dealer or other financial institution of Securities offered by this prospectus, which Securities such broker-dealer or other financial institution may resell pursuant to this prospectus (as supplemented or amended to reflect such transaction).

        The Selling Stockholders may, from time to time, pledge or grant a security interest in some or all of the Securities owned by them and, if they default in the performance of their secured obligations, the pledgees or secured parties may offer and sell the Securities from time to time pursuant to this prospectus or any amendment to this prospectus under Rule 424(b)(3) or other applicable provisionthe Plan. It may not answer all of the Securities Act, amending, if necessary,questions you might have about the list of Selling StockholdersPlan and is not intended to include the pledgee, transferee or other successors in interest as Selling Stockholders under this prospectus. The Selling Stockholders may also may transfer and donate Securities in other circumstances in which case the transferees, donees, pledgees or other successors in interest will be the selling beneficial owners for purposes of this prospectus.

        Any underwriter may engage in over-allotment transactions, stabilizing transactions, short-covering transactions and penalty bids in accordance with Regulation M under the Exchange Act of 1934.

        Underwriters, broker-dealers or agents who may become involved in the sale of Securities may engage in transactions with, and perform other services for, us in the ordinary course of their business for which they receive compensation.

        In effecting sales, the Selling Stockholders may engage broker-dealers or agents, who may in turn arrange for other broker-dealers to participate. Broker-dealers or agents may receive commissions, discounts or concessions from the Selling Stockholders and/or from the purchasers of Securities for whom the broker-dealers may act as agents or to whom they sell as principal, or both. The compensation to a particular broker-dealer may be in excess of customary commissions. To our knowledge, there is currently no plan, arrangement or understanding between any Selling Stockholders and any broker-dealer or agent regarding the sale of any Securities by the Selling Stockholders.

        The Selling Stockholders, any broker-dealers or agents and any participating broker-dealers that act in connection with the salego into every detail of the Securities covered by this prospectus may be "underwriters" under the Securities Act with respect to those Securities and will be subject to the prospectus delivery requirements of that Act. Any profit that the Selling Stockholders realize, and any compensation that any broker-dealer or agent may receive in connection with any sale, including any profit realized on resale of Securities acquired as principal, may constitute underwriting discounts and commissions. If the Selling Stockholders are deemed to be underwriters, the Selling Stockholders may be subject to certain liabilities under statutes including, but not limited to, Section 11, 12 and 17 of the Securities Act and Section 10(b) and Rule 10b-5 under the Exchange Act.

        The securities laws of some states may require the Selling Stockholders to sell the Securities in those states only through registered or licensed brokers or dealers. These laws may also require that we register or qualify the Securities for sale in those states unless an exemption from registration and qualification is available and the Selling Stockholders and we comply with that exemption.Plan. In addition, the anti-manipulation rules of Regulation M under the Securities Exchange Act of 1934 may apply to sales of Securities in the market and to the activities of the Selling Stockholders and their affiliates. Regulation M may restrict the ability of any person engaged in the distribution of the Securities to engage in market-making activities with respect to the Securities. All of the foregoing may affect the marketability of the Securities and the ability of any person to engage in market-making activities with respect to the Securities.

        If any Selling Stockholder notifies usplease note that he has entered into any material arrangement with a broker-dealer for the sale of Securities through a block trade, special offering, exchange distribution,


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over-the-counter distribution or secondary distribution, or a purchase by a broker or dealer, we will file any necessary supplement to this prospectus to disclose:

    the number of Securities involved in the arrangement;

    the terms of awards granted under the arrangement, includingPlan are not required to be the names of any underwriters, dealers or agents who purchase Securities, as required;

    the proposed selling price to the public;

    any discount, commission or other underwriting compensation;

    the place and time of deliverysame for the Securities being sold;

    any discount, commission or concession allowed, reallowed or paid to any dealers; and

    any other materialeveryone. The particular terms of the distributionyour awards are described further in your grant notice and applicable award agreement, forms of Securities.

        In addition, if the Selling Stockholder notifies us that a donee, pledgee, transferee or other successor-in-interest of the Selling Stockholder intends to sell any securities, we will file an amendmentwhich are filed as exhibits to the registration statement of which this prospectus forms a partpart.

You should have received a grant notice and award agreement describing the terms and conditions of or a supplement toyour award. Please note that if there are any inconsistencies between the information in this prospectus if required.

and the terms of the Plan (or your award), the terms of the Plan (or your award) will control.
You can request a copy of the Plan from our Stock Plan Administrator (our “Plan Administrator”) at Senseonics Holdings, Inc., 20415 Seneca Meadows Parkway, Germantown, MD 20876, telephone (301) 515-7260. Our Plan Administrator is also available to answer your questions regarding the Plan and its administration. You should direct questions relating to the tax consequences of your participation in the Plan to your personal tax advisor.
General Plan Provisions
1.

The validitypurpose of the Plan is to help the Company provide incentives for participants to exert maximum efforts for the success of the Company and provide a means by which such persons may benefit from increases in the value of shares of common stock of the Company.
The Plan provides for the discretionary grant of nonstatutory stock options and restricted stock unit awards (collectively, the “awards” or “stock awards”) to eligible recipients.
2.
When did the Plan become effective?
The Plan was approved by our board of directors (the “Board”) on January 10, 2023 (the “Effective Date”).
3.
Who is an eligible recipient of awards under the Plan?
Non-employees of Senseonics, including employees of Ascensia Diabetes Care Holdings AG (the “Employer”) who assist in the commercialization of the Company’s products and who have been selected for participation in the Plan are eligible to receive awards under the Plan (“Eligible Recipients”).
4.
Who determined whether I received an award and its terms?
The Compensation Committee of the Board (the “Compensation Committee”) administers and interprets the Plan. References to the Board in this document should be construed as references to the Compensation Committee, as applicable.
The Compensation Committee currently consists of four members of the Board. Each member of the Compensation Committee serves for so long as the Board deems appropriate and may be removed by the Board at any time. When the Compensation Committee grants an award under the Plan, the Compensation Committee has the discretion to determine the terms of the award, including the number of shares covered by any stock award. The Compensation Committee may delegate to one or more officers of the Company the authority to grant awards under the Plan to participants within the parameters set by the Board. Accordingly, the Compensation Committee or an authorized officer of the Company decided which type of award you were granted under the Plan and the terms of such award.
Members of the Board normally are nominated by the Board and elected annually by our stockholders. The Board is currently divided into three classes, and members of the Board are elected for staggered, three-year terms. All directors hold office until the expiration of the term for which they were elected and until

6


their successors are elected and qualified or until their earlier death, resignation, or removal from office. The entire Board or any individual director may be removed from office, prior to the expiration of a Board member’s term of office, only in the manner and within the limitations provided by our certificate of incorporation, bylaws and the law of Delaware. Information about the current members of the Board and the Compensation Committee is provided in the proxy statement for our last annual meeting of stockholders.
5.
What functions does the Board perform?
The Board has the authority to (i) determine who will be granted awards and the terms of each stock award; (ii) to construe and interpret the Plan and awards granted under it, including to correct any defects, omission or inconsistencies; (iii) to settle all controversies related to the Plan and awards; (iv) to accelerate the time at which an ward may be exercised or vest; (v) to prohibit the exercise of any option during a period of up to 30 days prior to any stock dividend, stock split, combination or exchange of shares, merger, consolidation or other distribution of Company assets to stockholders, or any other change affecting the shares of common stock being offered herebyor the share price of the common stock including any corporate transaction, for reasons of administrative convenience; (vi) to suspend or terminate the Plan at any time; (vii) to amend the Plan as deemed necessary or advisable; provided that stockholder approval will be sought if required by applicable law; no amendment will materially impair your award without your written consent; (viii) to submit any amendment to the Plan for stockholder approval, if required by applicable law or exchange listing standards; (ix) approve forms of award agreements and amend the terms of any one or more awards; (x) exercise such powers and perform such acts as deemed necessary or expedient to promote the best interests of the Company and that are not in conflict with the provisions of the Plan or awards; (xi) to adopt procedures and sub-plans necessary or appropriate to permit participation by otherwise Eligible Recipients who are foreign nationals or employed by the Employer outside of the United States; and (xii) to effect, with the consent of any materially adversely affected participant, (1) the reduction of the exercise, purchase or strike price of any outstanding option or stock award; (2) the cancellation and substitution of any outstanding stock award; or (3) any other action that is treated as a repricing under generally accepted accounting principles.
Additional information regarding the Board can be obtained by contacting our Plan Administrator as provided on the first page of this prospectus.
6.
How many shares of common stock may be issued under the Plan?
Subject to the provisions of the Plan relating to adjustment for stock splits, stock dividends, and comparable restructuring activities, the aggregate number of shares of our common stock that are available for issuance pursuant to awards under the Plan will not exceed 10,000,000 shares.
To the extent shares are subject to a stock award granted under the Plan which (i) expires or otherwise terminates without all of the shares covered by the stock award being issued, (ii) is settled in cash (that is, the holder of the stock award receives cash rather than stock), or (iii) are withheld in satisfaction of tax withholding obligations on such stock award or as consideration for the exercise price or purchase price of such stock award, then such expiration, termination, settlement, or withholding of such shares does not result in an issuance of such shares under the Plan and therefore will not reduce or offset the number of shares of our common stock that may be issued under the Plan. If any shares of our common stock issued under a stock award granted under the Plan are forfeited back to us because of the failure to vest, then the forfeited shares will revert to and again become available for issuance under the Plan (“Recycled Shares”).
Accordingly, the “Share Reserve” is a limitation on the number of shares of our common stock that may be issued pursuant to the Plan and does not limit the granting of awards because shares subject to awards which are granted but which are not issued do not reduce the Share Reserve and any Recycled Shares can be granted subject to awards more than once.
The stock issuable under the Plan may be shares of our authorized but unissued or reacquired common stock, including shares of our common stock the Company repurchases on the open market.
7.
Will I continue to receive awards under the Plan?
Whether or not awards will be granted to you under the Plan will depend on many factors, such as whether you continue to be an Eligible Recipient of awards under the Plan, the Company’s overall

7


performance, the Board’s then-current policy on granting awards, and the number of shares remaining in the Plan. Further, the Board has the authority to stop granting awards at any time.
Please note that your receipt of awards under the Plan does not and should not be construed to create an employment or other service relationship between you and the Company.
8.
Can the Board terminate the Plan or change its terms?
The Board may suspend or terminate the Plan at any time. No awards may be granted under the Plan while the Plan is suspended or after it is terminated. However, any termination of the Plan will not materially impair your rights under your then-outstanding awards without your written consent except as otherwise expressly provided for in the Plan. Also, the Board has the authority to amend the Plan’s terms, including amending the Plan to take into account tax, securities, or other laws or in response to changes in the accounting treatment of the awards. Some changes, like an amendment increasing the number of shares available for issuance under the Plan, require stockholder approval.
9.
Will I receive reports regarding my stock awards?
You will generally not receive regular reports regarding our stock award accounts, but you can always review any outstanding stock awards that you have on the Company’s stock plan administration website. Please contact our Plan Administrator for additional information.
Nonstatutory Stock Options
10.
What is an option?
An option is the right to purchase a specified number of shares of our common stock at a fixed price per share (the “exercise price”) payable at the time the option is exercised. Any option granted under the Plan will be a nonstatutory stock option.
11.
How was the exercise price of my option determined?
The Board determined the exercise price of options. The exercise price of each option will not less than the fair market value of a share of our common stock on the date the option was granted. You should review your option grant notice to determine the exercise price of your option.
12.
How is the fair market value of the Companys common stock determined?
The fair market value of our common stock will generally be the closing sales price on the NYSE American or other established stock exchange on the determination date, unless the Board provides otherwise. If there is no closing sales price for our common stock on the determination date, the fair market value will be the closing sales price on the last preceding date for which a quotation exists.
If there is no public market for our common stock, the Board will determine the fair market value in good faith and in a manner that complies with applicable tax rules.
13.
When can I exercise my option?
The Board determined certain terms of your option, including the date or dates after which you may exercise it. The Board has the authority to accelerate the vesting and exercise schedule of outstanding options.
We are not required to grant options with vesting and exercise terms that are the same for every participant, and the terms of your option may vary from the terms described above. Please review your option grant notice and option agreement carefully to determine the vesting and exercise terms of your option.
14.
How do I exercise my option?
You exercise your option by delivering your executed notice of exercise form and payment of the exercise price and any withholding taxes (to the extent applicable) to our Plan Administrator (or such other

8


person as we may designate), which may include using a web-based tool. You may have received a copy of the notice of exercise form with your option grant notice and agreement, either in writing or electronically. You can request additional copies of the exercise notice from our Plan Administrator. We may in the future establish other procedures for exercising your option.
15.
How do I pay the exercise price of my option?
The Board may, but is not required to, allow you to pay the exercise price as specified in your option agreement as follows: (a) in cash or by check, bank draft, or money order payable to the Company; (b) through a broker-assisted “same day sale” or “cashless exercise” procedure permitted by Regulation T of the U.S. Federal Reserve Board; or (c) in other forms of legal consideration acceptable to the Board and permitted by applicable law. Please review your option grant notice and agreement carefully to determine how you may pay the exercise price of your option.
16.
How do exercise programs through brokers work?
Your option agreement may allow you to exercise your option without first paying the exercise price through a “cashless exercise” ​(also known as a “broker-assisted exercise,” “same day sale” or “sell to cover” procedure). To use this procedure, the Company must have established a cashless exercise procedure and you must provide irrevocable instructions to a brokerage firm reasonably satisfactory to the Company to effect the immediate sale of the shares of our common stock purchased under your option and to pay over to the Company, out of the sale proceeds available on the settlement date, sufficient funds to cover the aggregate exercise price payable for the purchased shares plus all required withholding taxes (to the extent applicable). Concurrently with these instructions, you must also direct the Company to deliver the certificates for the purchased shares to the brokerage firm to complete the sale. You should contact our Plan Administrator for information regarding the cashless exercise program and to obtain an instruction form for your broker.
Restricted Stock Unit Awards
17.
What is a restricted stock unit award?
A restricted stock unit award represents your right to receive the economic equivalent of one share of our common stock for each restricted stock unit that vests. The Company may settle restricted stock units that vest by the delivery of shares of our common stock, their cash equivalent, a combination thereof, or any other form of consideration the Board determines and described in your restricted stock unit grant notice and agreement.
You do not generally have any rights as a stockholder until we issue the shares subject to the restricted stock units to you. Specifically, you will not have rights to vote the shares subject to your restricted stock units unless and until those shares are actually issued to you.
Please review your restricted stock unit grant notice and agreement to determine when your restricted stock units vest and the other terms and conditions of your restricted stock units.
18.
Do I have to pay for the shares subject to my restricted stock units?
Unless otherwise determined by the Board at the time of grant, your restricted stock unit award will be granted in consideration of your remaining an Eligible Recipient, such that you will not be required to make a payment with respect to your restricted stock units. If the Board does determine consideration must be paid by you, then such consideration may be paid in any form determined by the Board and permissible under applicable law.
19.
When do my restricted stock units vest?
Please review your restricted stock unit grant notice and agreement to determine when your restricted stock units vest.

9


Termination of Awards
20.
What happens to my award if I cease to be an Eligible Recipient?
Options:   Company options generally expire ten years after they are granted, although the term may be less than ten years. Further, if you cease to be an Eligible Recipient for any reason (including, without limitation, when your service with the Employer terminates), your option stops vesting immediately and you will generally not be able to exercise any unvested portion of your option after your service has terminated. Regardless of the reason for such cessation, your right to exercise the vested portion of your option generally terminates three months thereafter. Your option may provide for a shorter or longer period of time in which you may exercise your option, but in any event, you may not exercise your option after the expiration of its maximum term. Please review your option grant notice and agreement for the specific terms that apply.
Restricted Stock Units:   When you cease to be an Eligible Recipient for any reason, your restricted stock units stop vesting immediately and you generally will forfeit any unvested restricted stock units at the time of such cessation.
21.
What are the rights of my heirs upon my death?
Options:   If you cease to be an Eligible Recipient as a result of your death (or if you die within a specified period after you cease to be an Eligible Recipient), then your personal representative may exercise your option as to any vested portion. Your option agreement will specify the date by which the option must be exercised, which usually will be three months after your death. In any event, the option will not be exercisable after the expiration of its maximum term. Please review your option grant notice and agreement for the specific terms that apply.
Restricted Stock Units:   When you cease to be an Eligible Recipient for any reason, including due to your death, your restricted stock units stop vesting immediately and you generally will forfeit any unvested units at the time of such cessation.
Sale or Transfer of Awards
22.
Can I transfer my award to a relative or friend?
Options:   Options are generally not transferable, except by will or by the laws of descent and distribution. Please consult your option agreement to determine whether you may transfer your option. If your option is not transferable, only you may exercise it during your lifetime and you may not transfer it during your lifetime.
Restricted Stock Unit Awards:   Except as expressly provided in the Plan or your award agreement, restricted stock unit awards granted under the Plan may not be transferred or assigned by you. If your vested restricted stock unit award is settled in shares of our common stock, after such shares subject to your award have been issued, you are free to assign, hypothecate, donate, encumber or otherwise dispose of any interest in such shares provided that any such actions are in compliance with the provisions of the Plan and applicable law.
23.
Can I sell the stock I receive from my award immediately?
You may generally sell our common stock that you receive from exercising your option or the settlement of your restricted stock unit award, subject to your possession of “inside information,” as discussed below.
24.
If I am aware of inside information, can I sell my stock before this information is disclosed to the public?
No. Any Plan participant who effects transactions in our stock (or provides information to enable other persons to do so) on the basis of inside information is subject to both civil liability and criminal penalties, as well as disciplinary action by us and/or their employer. If you are aware of inside information

10


you may not sell shares of our stock, whether received upon exercise of an option, settlement of a restricted stock unit award or otherwise, before such information is disclosed to the public.
Generally, “inside information” is information that is both material (very important) and non-public (not disclosed through press releases, newspaper articles, or otherwise to the public that buys and sells securities). Material information may include projections, estimates, and proposals. Whether information is material will depend on the specific circumstances. A general test is whether dissemination of the information to the public would likely affect the market price of our stock or would likely be considered important by people who are considering whether to buy or sell our stock. Certainly, if the information makes you want to buy or sell, it would probably have the same effect on others.
If you are contemplating selling your shares and you think you might have inside information, you should discuss the matter with your supervisor or your employer’s in house legal counsel. If, after this discussion, it is determined that such information is inside information, you must wait to sell your shares until after the information has been made public or the information is no longer inside information, or longer if otherwise required under applicable law.
25.
Do I have to pay a commission when I exercise my option or when I later sell my stock?
You generally pay no commission when you exercise your option unless you engage in a same day sale. When you sell your shares, generally you must use a broker, and you can expect to be charged a commission. We will not buy from you, sell on your behalf (other than in certain circumstances to cover applicable exercise price or tax withholding obligations), or assist you in selling stock that you have received under the Plan.
Corporate Transactions
26.
What happens to my award if there is a change in the Companys capital structure?
If certain changes occur to the Company’s capitalization (e.g., a stock split, or a reverse stock split of our common stock), the Board will proportionately adjust the exercise price or purchase price (if applicable) and number and class of shares subject to your stock award.
27.
What happens to my award in the event of a corporate transaction?
Unless otherwise provided in your stock award agreement, your stock award will receive the following treatment, as applicable, as to all or any portion of your stock award in the event of a corporate transaction (as described below), contingent upon the closing or completion of the corporate transaction:
Stock Awards May be Assumed.   Subject to applicable law, in the event of a corporate transaction, any surviving or acquiring corporation may assume or continue your stock award or substitute a similar award for your stock award.
Treatment.   In the event of a corporate transaction, your vested stock award will terminate if not exercised prior to the occurrence of the corporate transaction. Any portion of your stock award that is unvested will be automatically forfeited without consideration.
Payment for Stock Awards Instead of Exercise.   Notwithstanding the above treatment of your stock award in connection with a corporate transaction, in the event your stock award will terminate if not exercised prior to the occurrence of a corporate transaction, the Board may provide, in its sole discretion, that you may not exercise your stock award but will receive a payment, in such form the Board determines, equal in value, at the occurrence of the corporate transaction, to the excess, if any, of (A) the value of the property you would have received upon the exercise of your stock award (including, at the Board’s discretion, any unvested portion of your stock award), over (B) the exercise price payable by you in connection with such exercise.
A “corporate transaction” occurs in the event of the consummation of (a) a sale or other disposition of all or substantially all of the consolidated assets of the Company and our subsidiaries; (b) a sale or other disposition of at least 50% of the Company’s outstanding securities; (c) a merger, consolidation, or similar

11


transaction following which the Company is not the surviving corporation; or (d) a merger, consolidation, or similar transaction following which the Company is the surviving corporation, but the shares of our common stock outstanding immediately preceding the transaction are converted or exchanged into other securities, cash, or other property because of the transaction.
The foregoing is merely a summary; please refer to the Plan document and your stock award agreement regarding what constitutes a corporate transaction.
28.
What happens to my award if the Company dissolves or liquidates?
Unless otherwise determined by the Board, if the Company dissolves or liquidates, all outstanding stock awards will terminate immediately prior to the dissolution or liquidation. The Board may provide, in its discretion, that some or all of the outstanding stock awards will become fully vested, exercisable, or no longer subject to forfeiture prior to the dissolution or liquidation.
Miscellaneous
29.
Is the Plan subject to ERISA or is it a qualified retirement plan?
The Plan is not subject to the U.S. Employee Retirement Income Security Act of 1974, as amended (“ERISA”). The Plan is not qualified under Section 401(a) of the Code and does not enjoy the tax deferral benefits of a qualified retirement plan.
U.S. TAX ISSUES RELATING TO YOUR PARTICIPATION IN THE PLAN
The information in this section responds to questions you may have about the income tax consequences of participating in the Plan that will be relevant to you if you are a U.S. taxpayer. The following summaries are based on the U.S. federal income tax consequences of participating in the Plan as of the date of this prospectus. Tax laws and regulations may change, and interpretations of these laws and regulations can change the way the laws and regulations apply to you. As a result, the information below may be out of date at the time you receive, exercise or vest in a stock award, or sell shares acquired under the Plan.
In addition, the tax information is not complete. For example, it does not address U.S. state or local tax laws or the application of laws if you are subject to the tax laws of other countries. You should know that non-U.S., U.S. state and local tax treatment may vary from the U.S. federal income tax treatment described herein. Further, this information is general in nature and does not discuss all of the various laws, rules and regulations that may apply. Moreover, the information in the summaries is based on assumptions that may or may not apply to your particular tax or financial situation. The Company is not in a position to assure you of any particular tax result.
You are strongly advised to consult your own independent personal tax advisors as to how the tax or other laws apply to your specific situation.
Nonstatutory Stock Options
30.
Do I have to pay tax when I receive a nonstatutory stock option?
No.
31.
How am I subject to tax if I exercise the vested portion of a nonstatutory stock option?
If you exercise the vested portion of a nonstatutory stock option when the fair market value of the stock is higher than the exercise price of your option, you generally are required to pay tax on the “spread,” that is, the excess of (a) the fair market value of the stock on the date of exercise, over (b) the exercise price. The spread on the exercise will be characterized as ordinary income and will be subject to applicable income and employment tax withholding in the case of employee optionees as described below. The Company will be entitled to a business expense deduction based on the amount of ordinary income that you recognize.

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32.
Will the Company withhold taxes on exercise of a nonstatutory stock option?
If you were an employee of the Company during any part of the option term, the Company is required to withhold federal and state income and employment taxes from the spread upon exercise or to otherwise ensure that the withholding taxes due will be paid. Generally, if the Company complies with this requirement, we are allowed a business expense deduction on the amount of ordinary income you recognized upon exercise of your nonstatutory stock option.
The amount of withholding may be insufficient to pay all applicable taxes that may be due with respect to the exercise of your options. See your tax advisor for more details. We are not obligated to issue the shares to you unless you make satisfactory arrangements with us to cover the amount of federal, state, local, and foreign tax withholding due upon the exercise of your nonstatutory stock option (to the extent applicable).
33.
How much tax do I pay when I sell stock received upon the exercise of a nonstatutory stock option?
If you exercised your nonstatutory stock option when the exercise price was lower than the fair market value on the date of exercise, you generally should have paid tax on the difference between the two. Upon the sale of your stock (or other taxable transfer) you generally will recognize a gain or loss equal to the difference between the sales price and the fair market value at the time of exercise. Generally, your gain or loss will be characterized as a long-term capital gain or loss if you held the stock for more than one year after the date the option was exercised, and a short-term capital gain or loss if you did not hold the stock for that period of time.
You should consult with your tax advisor if you have questions relating to the tax consequences of participation in and the sale of shares under the Plan.
Restricted Stock Unit Awards
34.
Am I subject to income tax when I receive a restricted stock unit award?
No. You generally will not recognize any income upon receipt of your restricted stock unit award.
35.
What are the tax consequences of the receipt of shares of common stock upon settlement of my vested restricted stock unit award?
You generally will recognize ordinary income equal to the fair market value of the underlying shares on the date the shares are delivered to you in settlement of your vested restricted stock unit award.
36.
Will the Company collect income and employment taxes on vesting or settlement of the shares subject to my restricted stock unit award?
When you vest in your restricted stock unit award (or, possibly later in the year when you are issued the shares), to the extent applicable, we generally must withhold income and employment taxes from other compensation payable to you in an amount based on the ordinary income you recognize, and we will generally be able to take a business expense deduction in the amount of ordinary income that you recognize at that time.
We are not obligated to issue the shares to you unless you make satisfactory arrangements with the Company to cover the amount of federal, state, local, and foreign tax withholding due (to the extent applicable) upon the vesting and delivery of your shares.
37.
What are the tax consequences upon my sale of the shares received upon settlement of my restricted stock unit award?
Upon a subsequent sale of any stock acquired pursuant to your restricted stock unit award, you will recognize a capital gain or loss equal to the difference between the sale price and the sum of the amount paid for such stock plus any amount recognized as ordinary income upon acquisition of the stock. Such gain

13


or loss will be long-term or short-term depending on whether the stock was held for more than one year from the date of delivery.
LEGAL MATTERS
Certain legal matters in connection with the offering and the validity of the securities offered by this prospectus have been passed upon for us by Cooley LLP, Reston, Virginia. Any underwriters will also be advised about the validity of the shares of common stock and other legal matters by their own counsel, which will be named in the applicable prospectus supplement.


EXPERTS

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EXPERTS

Ernst & Young LLP, independent registered public accounting firm, has audited our consolidated financial statements included in ourAnnual Report on Form 10-K for the year ended December 31, 2019, and the effectiveness of our internal control over financial reporting as of December 31, 2019,2021 included in our Annual Report on Form 10-K for the year ended December 31, 2021, as set forth in their reports, (which contains an explanatory paragraph describing conditions that raise substantial doubt about the Company's ability to continue as a going concern as described in Note 2 to the consolidated financial statements), which are incorporated by reference in this prospectus and elsewhere in the registration statement. KPMG LLP, independent registered public accounting firm, has been engaged as the Company’s new independent registered public accounting firm for the Company’s fiscal year ending December 31, 2022. Our financial statements are incorporated by reference in reliance on Ernst & Young LLP'sLLP’s reports, given on their authority as experts in accounting and auditing.


14


PART II
INFORMATION NOT REQUIRED IN THE PROSPECTUS

Item 14.
Other Expenses of Issuance and Distribution

The following table sets forth an estimate of the fees and expenses, other than underwriting discounts and commissions, payable by the registrant in connection with the issuance and distribution of the securities being registered. All the amounts shown are estimates, except for the SEC registration fee.

SEC registration fee$1,135
Accounting fees and expenses20,000
Legal fees and expenses200,000
Printing and miscellaneous expenses5,000
Total$226,135

Registration Fee

 $4,188 

Legal Fees and Expenses

  50,000 

Accounting Fees and Expenses

  20,000 

Miscellaneous Fees and Expenses

  15,812 

Total

 $90,000 

Item 15.

Indemnification of Officers and Directors

Under Section 145 of the Delaware General Corporation Law, or DGCL, we have broad powers to indemnify our directors and officers against liabilities they may incur in such capacities, including liabilities under the Securities Act of 1933, as amended, or the Securities Act. Section 145 of the DGCL generally provides that a Delaware corporation has the power to indemnify its present and former directors, officers, employees and agents against expenses incurred by them in connection with any suit to which they are or are threatened to be made, a party by reason of their serving in such positions so long as they acted in good faith and in a manner they reasonably believed to be in or not opposed to, the best interests of the corporation and, with respect to any criminal action, they had no reasonable cause to believe their conduct was unlawful.

Our amended and restated certificate of incorporation and amended and restated bylaws include provisions that (i) eliminate the personal liability of our directors for monetary damages resulting from breaches of their fiduciary duty to the fullest extent permitted under applicable law, (ii) require us to indemnify our directors and executive officers to the fullest extent permitted by the DGCL or other applicable law and (iii) provide us with the power, in our discretion, to indemnify our other officers, employees and other agents as set forth in the DGCL or other applicable law. We believe that these provisions of our amended and restated certificate of incorporation and amended and restated bylaws are necessary to attract and retain qualified persons as directors and officers. These provisions do not eliminate our directors'directors’ or officers'officers’ duty of care, and, in appropriate circumstances, equitable remedies such as injunctive or other forms of non-monetary relief will remain available under the DGCL. In addition, each director will continue to be subject to liability pursuant to Section 174 of the DGCL, for breach of such director'sdirector’s duty of loyalty to us, for acts or omissions not in good faith or involving intentional misconduct, for knowing violations of law, for acts or omissions that such director believes to be contrary to our best interests or the best interests of our stockholders, for any transaction from which such director derived an improper personal benefit, for acts or omissions involving a reckless disregard for such director'sdirector’s duty to us or to our stockholders when such director was aware or should have been aware of a risk of serious injury to us or to our stockholders, for acts or omission that constitute an unexcused pattern of inattention that amounts to an abdication of such director'sdirector’s duty to us or to our stockholders, for improper transactions between such director and us and for improper loans to directors and officers. These provisions also do not affect a director'sdirector’s responsibilities under any other law, such as the federal securities law or state or federal environmental laws.

As permitted by Delaware law, we have entered into indemnification agreements with each of our current directors and officers pursuant to the foregoing provisions. We have an insurance policy


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covering our officers and directors with respect to certain liabilities, including liabilities arising under the Securities Act or otherwise.

        The underwriting agreement, if any, entered into with respect to an offering of securities registered hereunder will provide for indemnification by any underwriters of any offering, our directors and officers who sign the registration statement and our controlling persons for some liabilities, including liabilities arising under the Securities Act.


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Item 16.
Exhibits and Financial Statement Schedules

Exhibit
Number
Exhibit
Number
Description of Document
4.13.1Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant'sRegistrant’s Current Report on Form 8-K (File No. 001-37717), filed with the SEC on March 23, 2016).


4.23.2


Certificate of Amendment to Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.3 to the Registrant'sRegistrant’s Quarterly Report on Form 10-Q (File No 001-37717), filed with the SEC on August 8, 2018).


4.33.3


Certificate of Designation of Preferences, Rights and Limitations of Series A Convertible Preferred Stock (incorporated herein by reference to Exhibit 3.1 to the Registrant’s Current Report on Form 8-K (File No. 001-37717), filed with the Commission on August 18, 2020).
3.4Certificate of Designation of Preferences, Rights and Limitations of Series B Convertible Preferred Stock (incorporated herein by reference to Exhibit 3.5 to the Registrant’s Quarterly Report on Form 10-Q (File No. 001-37717), filed with the Commission on November 8, 2022).
3.5


4.43.6


Specimen stock certificate evidencing sharesAmendment to Bylaws of Common StockSenseonics Holdings, Inc. (incorporated herein by reference to Exhibit 4.2 to Amendment No. 23.7 to the Registrant's Registration Statement on Form S-1 (File No. 333-208984), filed with the SEC on March 8, 2016).


4.5


Registration Rights Agreement, dated as of December 7, 2015, by and among the Registrant and certain of its stockholders (incorporated by reference to Exhibit 4.1 to the Registrant's Current Report on Form 8-K (File No. 333-198168), filed with the SEC on December 10, 2015).


4.6


Registration Rights Agreement, dated as of April 21, 2020, by and between the Registrant, and Highbridge Tactical Credit Master Fund, L.P. (incorporated by reference to Exhibit 10.2 to the Registrant's Amendment toRegistrant’s Annual Report on Form 10-K (File No. 001-37717), filed with the SECCommission on April 28, 2020)March 5, 2021).


4.74.1*




5.14.2*


4.3*
5.1*


23.123.1*




23.223.2*




24.124.1*


107*
*

Filed herewith
Undertakings

The undersigned Registrantregistrant hereby undertakes:

        (a)

(1)   To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:

      registration statement:
(i)
to   To include any prospectus required by Section 10(a)(3) of the Securities Act;

(ii)
to   To reflect in the prospectus any facts or events arising after the effective date of the Registration Statementregistration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement.registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be

II-2


reflected in the form of prospectus filed with the SEC pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the "Calculation“Calculation of Registration Fee"Fee” table in the effective Registration Statement;registration statement; and

(iii)
to   To include any material information with respect to the plan of distribution not previously disclosed in the Registration Statementregistration statement or any material change to such information in the Registration Statement;

    registration statement;

provided, however, that the undertakings set forth in paragraphs (a)(1)(i), (a)(1)(ii) and (a)(1)(iii) above do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in periodic reports filed with or furnished to the SEC by the Registrantregistrant pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934, as amended, or the Exchange Act, that are incorporated by reference in the Registration Statement,this registration statement or isare contained in a form of prospectus filed pursuant to Rule 424(b) that is part of the Registration Statement.

this registration statement.

(2)   That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(3)   To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

(4)   That, for the purpose of determining liability under the Securities Act to any purchaser:

(i)
Each prospectus filed by the Registrantregistrant pursuant to Rule 424(b)(3) shall be deemed to be part of the Registration Statementregistration statement as of the date the filed prospectus was deemed part of and included in the Registration Statement;registration statement; and

(ii)
Each prospectus required to be filed pursuant to Rule 424(b)(2), (b)(5), or (b)(7) as part of a registration statement in reliance on Rule 430B relating to an offering made pursuant to Rule 415(a)(1)(i), (vii), or (x) for the purpose of providing the information required by Section 10(a) of the Securities Act of 1933 shall be deemed to be part of and included in the Registration Statementregistration statement as of the earlier of the date such form of prospectus is first used after effectiveness or the date of the first contract of sale of securities in the offering described in the prospectus. As provided in Rule 430B, for liability purposes of the issuer and any person that is at that date an underwriter, such date shall be deemed to be a new effective date of the Registration Statementregistration statement relating to the securities in the Registration Statementregistration statement to which that prospectus relates, and the

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        offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. Provided, however, that no statement made in a registration statement or prospectus that is part of the Registration Statementregistration statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the Registration Statementregistration statement will, as to a purchaser with a time of contract of sale prior to such effective date, supersede or modify any statement that was made in the registration statement or prospectus that was part of the Registration Statementregistration statement or made in any such document immediately prior to such effective date.

(5) That, for the purpose of determining liability of the Registrantregistrant under the Securities Act of 1933 to any purchaser in the initial distribution of the securities, the undersigned Registrantregistrant undertakes that in a primary offering of securities of the undersigned Registrantregistrant pursuant to this Registration Statement,registration statement, regardless of the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means of any of the following communications, the undersigned Registrantregistrant will be a seller to the purchaser and will be considered to offer or sell such securities to such purchaser:

    (i)
    Any any preliminary prospectus or prospectus of the undersigned Registrantregistrant relating to the offering required to be filed pursuant to Rule 424;

    (ii)
    Any any free writing prospectus relating to the offering prepared by or on behalf of the undersigned Registrantregistrant or used or referred to by the undersigned Registrant;

    registrant; (iii)
    The the portion of any other free writing prospectus relating to the offering containing material information about the undersigned Registrantregistrant or its securities provided by or on

II-3


behalf of the undersigned Registrant;registrant; and

(iv)
Any any other communication that is an offer in the offering made by the undersigned Registrantregistrant to the purchaser.

        (b)   The undersigned Registrant hereby undertakes that,

(6)   That, for purposes of determining any liability under the Securities Act, each filing of the Registrant'sregistrant’s annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan'splan’s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the Registration Statementregistration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

        (c)

(7)   Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrantregistrant pursuant to the foregoing provisions, or otherwise, the Registrantregistrant has been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrantregistrant of expenses incurred or paid by a director, officer or controlling person of the Registrantregistrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrantregistrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.


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SIGNATURESSIGNATURES

Pursuant to the requirements of the Securities Act, the Registrant has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Germantown, State of Maryland, on April 30, 2020.

January 10, 2023.
SENSEONICS HOLDINGS, INC.



By:


By:
/s/ TIMOTHY T. GOODNOW,

PH.D.
Timothy T. Goodnow, Ph.D.
President and Chief Executive Officer

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Timothy T. Goodnow and Nick B. Tressler,Rick Sullivan, and each of them, his true and lawful agent, proxy and attorney-in-fact, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to (i) act on, sign and file with the Securities and Exchange Commission any and all amendments (including post-effective amendments) to this registration statement together with all schedules and exhibits thereto and any subsequent registration statement filed pursuant to Rule 462(b) under the Securities Act of 1933, as amended, together with all schedules and exhibits thereto, (ii) act on, sign and file such certificates, instruments, agreements and other documents as may be necessary or appropriate in connection therewith, (iii) act on and file any supplement to any prospectus included in this registration statement or any such amendment or any subsequent registration statement filed pursuant to Rule 462(b) under the Securities Act of 1933, as amended, and (iv) take any and all actions which may be necessary or appropriate to be done, as fully for all intents and purposes as he might or could do in person, hereby approving, ratifying and confirming all that such agent, proxy and attorney-in-fact or any of his substitutes may lawfully do or cause to be done by virtue thereof.


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Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

Signature
Signature
Title
Date




Date

/s/ TIMOTHY T. GOODNOW,

PH.D.
Timothy T. Goodnow, Ph.D.
President, Chief Executive Officer and Director (Principal(Principal Executive Officer)April 30, 2020January 10, 2023

/s/ NICK B. TRESSLER

Nick TresslerRICK SULLIVAN
Rick Sullivan


Chief Financial Officer (Principal(Principal Financial Officer and Principal Accounting Officer)

April 30, 2020
January 10, 2023

/s/ DOUGLAS S. PRINCE

Douglas S. Prince


Director

Director

April 30, 2020
January 10, 2023

/s/ PETER JUSTIN KLEIN

Peter Justin Klein


Director


April 30, 2020

/s/ DOUGLAS A. ROEDER

Douglas A. Roeder


Director

Director

April 30, 2020
January 10, 2023

/s/ EDWARD J. FIORENTINO

Edward J. Fiorentino


Director

Director

April 30, 2020
January 10, 2023

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SignatureTitleDate

/s/ FRANCINE KAUFMAN

Francine Kaufman


Director


April 30, 2020

/s/ STEPHEN P. DEFALCO

Stephen P. DeFalco


Director

Chairman of the Board of Directors

April 30, 2020
January 10, 2023

/s/ STEVEN EDELMAN,

M.D.
Steven Edelman


Director

Director

April 30, 2020
January 10, 2023
/s/ FRANCINE R. KAUFMAN, M.D.
Francine Kaufman
Chief Medical Officer and DirectorJanuary 10, 2023
/s/ JOHN MAROTTA
John Marotta
DirectorJanuary 10, 2023
/s/ ANTHONY RAAB
Anthony Raab
DirectorJanuary 10, 2023
/s/ ROBERT SCHUMM
Robert Schumm
DirectorJanuary 10, 2023
/s/ SHARON LARKIN
Sharon Larkin
DirectorJanuary 10, 2023

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