Additional research and development activities remain ongoing through preclinical research examining the potential to treat a broad set of neuroinflammatory, autoimmune and viral diseases with new molecules leveraging our chemical and pharmacological research platform as well as generated intellectual property in these areas.

We expect to continue to lead most of our research and development activities from our Gräfelfing, Germany location, where dedicated scientific, regulatory, clinical and medical teams conduct their activities. Due to these teams' key relationships with local and international service providers, we anticipate that this will result in more timely and cost-effective execution of our development programs. In addition, we are using our subsidiary in Melbourne, Australia to expediteperform research and development activities in the early clinical trials for IMU-935 and IMU-856.Australasia region. We also conduct preclinical work in Halle/Saale, Germany through a collaboration with the Fraunhofer Institute.

Our business, operating results, financial condition and growth prospects are subject to significant risks and uncertainties, including the failure of our clinical trials to meet their endpoints, failure to obtain regulatory approval and failure to obtain needed additional funding on acceptable terms, if at all, to complete the development and commercialization of our three development programs.

Acquisition History

Our wholly-owned subsidiary Immunic AG acquired IMU-838vidofludimus calcium and IMU-935izumerogant in September 2016 through asset acquisitions from 4SC AG (hereinafter, “4SC”), a publicly traded company based in Planegg-Martinsried, near Munich, Germany, through asset acquisitions. Germany. On March 31, 2021, Immunic AG and 4SC entered into a Settlement Agreement, pursuant to which Immunic AG settled its remaining obligation of a 4.4% royalty on net sales for $17.25 million. The payment was made 50% in cash and 50% in shares of Immunic’s common stock.

Our rights to IMU-856 are secured pursuant to an option and license agreement (the “Daiichi Sankyo Option”) with Daiichi Sankyo Co., Ltd. (hereinafter, "Daiichi Sankyo") in Tokyo, Japan. On January 5, 2020, Immunic AG exercised its option under the agreement with Daiichi Sankyo Option to acquire the exclusive global rights to commercialize IMU-856. The license also grants Immunic AG the rights to Daiichi Sankyo’s patent application related to IMU-856. Concurrent with the option exercise, Immunic AG paid to Daiichi Sankyo a one-time upfront licensing fee. Going forward, Daiichi Sankyo is eligible to receive future development, regulatory and sales milestone payments, as well as royalties related to IMU-856.

Commercialization Strategy

Our products are being developed with the aim of demonstrating meaningful improvements over the current standard of care in a number of chronic inflammatory and autoimmune diseases. Our focus to date has been to execute state-of-the-art clinical trials in an efficient manner in order to show clinically meaningful benefits that ultimately facilitate broad commercial adoption in major markets, either by ourselves or through partnerships.

We expect to continue to lead most of our research and development activities from our Grafelfing, Germany location, where dedicated scientific, regulatory, clinical and medical teams conduct their activities. Due to these teams’ key relationships with local and international service providers, we anticipate that this is likely to result in more timely, cost-effective execution of our development programs. In addition, we leverage our global presence, including our subsidiary based in Melbourne, Australia, to expedite early clinical development of our programs.

Corporate Information

Prior to April 12, 2019, we were a clinical-stage biotherapeutic company known as Vital Therapies, Inc. that had historically been focused on the development of a cell-based therapy targeting the treatment of acute forms of liver failure. Vital Therapies, Inc. was originally incorporated in the State of California in May of 2003 as Vitagen Acquisition Corp., subsequently changed its name to Vital Therapies, Inc. in June 2003, and reincorporated in Delaware in January 2004. In April 2019, we completed an exchange transaction with Immunic AG pursuant to which holders of ordinary shares of Immunic AG exchanged all of their shares for shares of our common stock, resulting in Immunic AG becoming our wholly owned subsidiary. Following the exchange, we changed our name to Immunic, Inc. and we became a clinical-stage biopharmaceutical company focused on the development of selective oral therapies in immunology with the goal of becoming a leader in treatments for chronic inflammatory and autoimmune diseases.

Our corporate headquarters are located at 1200 Avenue of the Americas, Suite 200, New York, New York 10036. We also have an office at Lochhamer Schlag 21, 82166 Grafelfing,Graefelfing, Germany and a research laboratory in Planegg, Germany. Our telephone number is (332) 255-9818.

We maintain a website at www.imux.com. The information contained on, or that can be accessed through, ourthe website is not a part of this prospectus. Investors should not rely on any such information in deciding whether to purchase shares of our common stock. We have included our website address in this prospectus solely as an inactive textual reference.

Our Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q, Current Reports on Form 8-K and all amendments to those reports filed or furnished pursuant to Section 13(a) or 15(d) of the Exchange Act are available free of charge through the investor relations page of our internet website as soon as reasonably practicable after we electronically file such material with, or furnish it to, the SEC.

ABOUT THIS OFFERING

This prospectus relates to the resale by the selling stockholders identified in this prospectus of up to 13,793,10455,944,850 shares of our common stock. All of the shares, if and when sold, will be sold by the selling stockholders. The selling stockholders may sell their shares of common stock from time to time at prices and on terms that will be determined by each selling stockholder at the time of sale. We will not receive any proceeds from the sale of the shares of common stock by the selling stockholders.

RISK FACTORS

Investment in any securities offered pursuant to this prospectus involves risks. You should carefully consider the risk factors incorporated by reference to our most recent Annual Report on Form 10-K and any subsequent Quarterly Reports on Form 10-Q or Current Reports on Form 8-K we file after the date of this prospectus, and all other information contained or incorporated by reference into this prospectus, as updated by our subsequent filings under the Exchange Act, and the risk factors and other information contained in any applicable prospectus supplement, before acquiring any of such securities. The occurrence of any of these risks might cause you to lose all or part of your investment in the offered securities.

Risks Related to the Offering and Shares of Our Common Stock

We have a limited operating history with our current business plan, have incurred significant losses since 2016, anticipate that we will continue to incur significant and increasing losses for the foreseeable future and may never achieve or maintain profitability. The absence of any commercial sales and our limited operating history make it difficult to assess our future viability.

We are a development-stage pharmaceutical company with a limited operating history with our current business plan. Our net losses were $92.9$93.6 million and $44.0$120.4 million for the years ended December 31, 20212023 and 2020,2022, respectively. As of September 30, 2022,December 31, 2023, we had an accumulated deficit of $260.8$410.9 million to date and have not generated any revenue from our current product candidates. Moreover, Immunic AG, the company’s operating subsidiary, has only a limited operating history upon which stockholders can evaluate our business and prospects, is not profitable and has incurred losses in each year since its inception in 2016. In addition, we have limited experience and have not yet demonstrated an ability to successfully overcome many of the risks and uncertainties frequently encountered by companies in new and rapidly evolving fields, particularly in the biotechnology industry.

We have devoted substantially all of our financial resources to identify, acquire and develop our product candidates, including providing general and administrative support for our operations. We expect our losses to increase as we continue to conduct clinical trials and continue to develop our lead product candidates. We expect to continue to invest significant funds into the research and development of our current product candidates to determine the potential to advance these product candidates to seek regulatory approval. To date, we have financed our operations primarily through the sale of equity securities. The amount of our future net losses will depend, in part, on the rate of our future expenditures and our ability to obtain funding through equity or debt financings, strategic collaborations or grants.

We do not expect to generate significant revenue unless and until we are able to obtain marketing approval for, and successfully commercialize, any current or future product candidate. However pharmaceutical product development is an extremely costly and highly speculative undertaking and involves a substantial degree of risk. In addition, if we obtain regulatory approval to market a product candidate, our future revenue will depend upon the size of any markets in which our product candidates may receive regulatory approval, and our ability to achieve sufficient market acceptance, pricing, reimbursement from third-party payors, and adequate market share for our product candidates. Even if we eventually obtain adequate market share for our product candidates, to the extent they receive regulatory and market approval, the potential markets for our product candidates may not be large enough for us to become profitable.

We expect to continue to incur significant expenses and increasing operating losses for the foreseeable future, and our expenses will increase substantially if and as we:

•continue the clinical development of our product candidates;

•continue efforts to discover, develop and/or acquire new product candidates;

•undertake the manufacturing of our product candidates for clinical development and, potentially, commercialization, or increase volumes manufactured by third parties;

•advance our programs into larger, more expensive clinical trials;

•initiate additional preclinical, clinical, or other trials or studies for our product candidates;

•seek regulatory and marketing approvals and reimbursement for our product candidates;

•experience any delays or encounter issues with the development and process for regulatory approval of our product candidates such as safety issues, clinical trial accrual delays, longer follow-up for planned studies, additional major studies or supportive studies necessary to support marketing approval;

•establish a sales, marketing and distribution infrastructure to commercialize any products for which we may obtain marketing approval and market for our self;

•make milestone, royalty or other payments under any third-party license agreements;

•seek to maintain, protect and expand our intellectual property portfolio;

•seek to retain current skilled personnel and attract additional personnel; and

•add operational, financial and management, and information systems personnel, including personnel to support our product development and commercialization efforts.

Further, the net losses we incur may fluctuate significantly from quarter to quarter and year to year, such that a period-to-period comparison of our results of operations may not be a good indication of our future performance. Failure to become and remain profitable would decrease the value of our company and the trading price of our common stock and could impair our ability to raise capital, expand our business, maintain our development efforts, expand our pipeline of product candidates or continue our operations.

Investment in our common stock is speculative and involves a high degree of risk. You may lose your entire investment.

There is no guarantee that sharesShares of our common stock willmay not earn any positive return in the short term or long term. Investing in our common stock is speculative and involves a high degree of risk and should be undertaken only by holdersinvestors whose financial resources are sufficient to enable them to assume such risks and who have no need for immediate liquidity in their investment. Purchasing shares of our common stock is appropriate only for holdersinvestors who have the capacity to absorb a loss of some or all of their holdings.

We will not receive any of the proceeds from the sale of shares of common stock in this offering, so your purchase of shares will not directly benefit the Company.

The selling stockholders will receive all of the net proceeds from the sale of shares of common stock in this offering. We will not receive any proceeds from the sale of shares of common stock in this offering, so we will not directly benefit from your purchase. We will, however, bear the costs and expenses incurred in connection with the registration of these shares of common stock.

The market price for shares of our common stock is volatile and subject to wide fluctuations in response to numerous factors, many of which are beyond our control.

The market price of our common stock has been, and is expected to continue to be, subject to significant fluctuations. Market prices for securities of early-stage pharmaceutical, biotechnology and other life sciences companies have historically been particularly volatile. Some of the factors that may cause the market price of our common stock to fluctuate include:

•reports on, or the perception of, clinical trial progress, or the lack thereof, such as our announcement on October 20, 2022 of the interim group-level data of our phase 1b clinical trial of IMU-935 in psoriasis, which resulted in a significant decline in the market price of our common stock;

•our ability to obtain regulatory approvals for our product candidates, and delays or failures to obtain such approvals;

•failure of any of our approved product candidates to achieve commercial success;

•failure to maintain our existing third-party license, supply and manufacturing agreements;

•failure by us or our licensors to prosecute, maintain, or enforce our intellectual property rights;

•changes in laws or regulations (or their interpretation) applicable to our product candidates;

•any inability to obtain adequate supply of our product candidates or the inability to do so at acceptable prices;

•adverse regulatory authority decisions or delays;

•introduction of new products, services, or technologies by our competitors;

•failure to meet or exceed financial and development projections that we may provide to the public;

•failure to meet or exceed the financial and development projections of the investment community;

•the perception of the pharmaceutical industry in general, and companies addressing our disease indications in particular, by the public, legislatures, regulators and the investment community;

•announcements of significant acquisitions, strategic collaborations, joint ventures, or capital commitments by us or our competitors;

•disputes or other developments relating to proprietary rights, including patents, litigation matters, and our ability to obtain patent protection for our technologies;

•additions or departures of key personnel;

•significant lawsuits, including patent, product liability or stockholder litigation;

•if securities or industry analysts do not publish research or reports about our business, or if they issue negative or misleading opinions regarding our business and stock;

•changes in the market valuations of similar companies;

•general market or macroeconomic conditions;

•sales of common stock by the company or our stockholders in the future;

•trading volume of our common stock;

•announcements by commercial partners or competitors of new commercial products, clinical progress or the lack thereof, significant contracts, commercial relationships or capital commitments;

•adverse publicity relating to the markets in which we operate, including with respect to other products and product candidates in such markets;

•the introduction of technological innovations or new therapies that compete or might compete with our product candidates;

•changes in the structure of healthcare payment systems; and

•period-to-period fluctuations in our financial results.

Moreover, stock markets in general have experienced substantial volatility that has often been unrelated to the operating performance of individual companies. These broad market fluctuations have had, and can be expected to continue to have, adverse effects on the trading price of our common stock.

In the past, following periods of volatility in the market price of a company’s securities, stockholders have often instituted class action securities litigation against those companies. Such litigation, if instituted, could result in substantial costs and diversion of management attention and resources, which could significantly harm our profitability and reputation.

Additionally, a decrease in our stock price may cause our common stock to no longer satisfy the continued listing standards of The Nasdaq Global Select Market. If we are not able to maintain the requirements for listing on The Nasdaq Global Select Market, we could be delisted, which would likely result in an immediate and significant decline in the trading price and liquidity of our stock, and would have a materially adverse effect on our ability to raise additional funds.

Our failure to meet the $1.00 minimum bid price or other continued listing requirements of Nasdaq could result in a delisting of our common stock, which could negatively impact the market price and liquidity of our common stock and our ability to access the capital markets. 

Any Nasdaq action relating to a delisting could have a negative effect on the price of our common stock, impair the ability to sell or purchase our common stock when persons wish to do so, and any such delisting action may materially adversely affect our ability to raise capital or pursue strategic restructuring, refinancing or other transactions on acceptable terms, or at all. Delisting from the Nasdaq Global Select Market could also have other negative results, including the potential loss of institutional investor interest, reduced research coverage, and fewer business development opportunities.

In the event of any delisting or potential delisting, we may attempt to take actions to restore our compliance with Nasdaq’s listing requirements, but we can provide no assurance that any such action taken by us would allow our common stock to remain listed or be re-listed, stabilize the market price or improve the liquidity of our common stock, maintain a minimum closing bid price of $1.00 per share for 10 consecutive trading days as required for continued listing on the Nasdaq Global Select Market pursuant to Nasdaq Listing Rule 5450(a)(1) or prevent future non-compliance with Nasdaq’s listing requirements.

Your ownership interest will be diluted and our stock price could decline when we issue additional shares of common stock.

We expect to issue from time to time in the future additional shares of our common stock or securities convertible into, or exercisable or exchangeable for, shares of our common stock, in connection with possible financings, acquisitions, equity incentives for employees or otherwise. Any such issuance could result in substantial dilution to existing stockholders and cause the trading price of our common stock to decline.

We have never paid cash dividends and investors should not expect us to do so in the foreseeable future.

The current expectation is that we will retain any future earnings to fund the development and growth of our business. As a result, any capital appreciation of our common stock will be stockholders’ sole source of any gain for the foreseeable future.

If securities or industry analysts do not publish research or publish inaccurate or unfavorable research about our business, our share price and trading volume could decline.

The trading market for shares of our common stock will depend in part on the research and reports that securities or industry analysts publish about us or our business, which research and reports are not and would not be subject to our control. We currently receive research coverage by securities analysts, but industry analysts that currently cover us may cease to do so. If industry analysts cease coverage of our company, the trading price for our common stock could be materially and adversely impacted. If one or more of the analysts who cover us downgrade the common stock or publish inaccurate or unfavorable research about our business, our share price may be materially and adversely impacted. If one or more of these analysts cease coverage of our company or fail to publish reports on us regularly, demand for our shares could decrease, which might cause our share price, trading volume and liquidity to decline.

A decline in the price of our common stock could affect our ability to raise any required working capital and adversely impact our operations.

A decline in the price of our common stock could result in a reduction in the liquidity of the common stock and a reduction in our ability to raise any required capital for our operations. A reduction in our ability to raise equity capital in the future may have a material adverse effect upon our business plan and operations. If our share price declines, we may not be able to raise additional capital or generate funds from operations sufficient to meet our obligations.

If our stockholders do not approve an increase in the number of authorized shares of our common stock, our ability to raise additional capital, to fund our operations and to incentivize our employees will be extremely limited.

We currently have 130,000,000 shares of common stock authorized for issuance and a total of 45,177,730 shares issued and outstanding as of January 31, 2024. We have asked our stockholders to approve an amendment to our certificate of incorporation to increase our authorized shares of common stock to 500,000,000 shares, at a Special Meeting of Stockholders to be held on March 4, 2024. The Securities Purchase Agreement with the selling stockholders named in this prospectus requires us to submit this proposal to our stockholders for approval at the Special Meeting and, if not approved, to resubmit this proposal to stockholders for approval at least semi-annually until approval is obtained. If holders of a majority of the total outstanding shares of our common stock do not vote in favor of this proposal at the Special Meeting on March 4, 2024, our ability to raise additional equity financing will be severely limited, which will impair our ability to fund the future needs of our business, unless and until we are able to generate sufficient revenue from operations.

USE OF PROCEEDS

We will not receive any proceeds from the sale of the 13,793,10455,944,850 shares of common stock by the selling stockholders under this prospectus (and/or their respective pledgees, donees, transferees, distributees, or other successors in interest that receive any such shares as a gift, partnership distribution or other non-sale related transfer).

We will incur all costs associated with the preparation and filing of the registration statement of which this prospectus is a part. The selling stockholders will each bear their respective brokerage fees, commissions and discounts, fees and other expenses, if any, attributable to the sale or disposition of the shares held by such selling stockholder.

SELLING STOCKHOLDERS

The selling stockholders acquired the shares of common stock being registered for resale under this prospectus pursuant to a Securities Purchase Agreement, dated October 10, 2022,January 4, 2024, by and among us and the selling stockholders. Pursuant to the Securities Purchase Agreement, we issued and sold in a private placement to select accredited investors and certain existing investors: (i) 8,696,55244,751,286 shares of our common stock, par value $0.0001 per share, at a purchase price of $4.35$1.43 per share; and (ii) 5,096,55211,193,564 pre-funded warrants at a purchase price of $4.34$1.43 per pre-funded warrant, to purchase shares of our common stock for an exercise price of $0.01$0.0001 per share of common stock.

The pre-funded warrants are immediately exercisable and remain exercisable until exercised in full. However, under the terms of the pre-funded warrants, a selling stockholder may not exercise the pre-funded warrants to the extent such exercise would cause such selling stockholder, together with its affiliates and attribution parties, to beneficially own a number of shares of common stock which would exceed 9.99%9.90% (or for selling stockholders who so elect, 5.99%) of our then outstanding shares of common stock following such exercise, excluding for purposes of such determination shares of common stock issuable upon exercise of such pre-funded warrants which have not been exercised. The number of shares of common stock in the columns below do not reflect this limitation.

The private placement closed on October 12, 2022.January 8, 2024. The gross proceeds of the private placement were approximately $60.0$80.0 million, before deducting offering expenses payable by us. We intend to use the net proceeds from the private placement to fund the ongoing clinical development of our three lead product candidates, vidofludimus calcium (IMU-838), IMU-935 and IMU-856, and for other general corporate purposes.

The Securities Purchase Agreement provides for the registration for resale of the (i) 8,696,55244,751,286 shares of our common stock sold in the private placement and (ii) 5,096,55211,193,564 shares of our common stock issuable upon exercise of pre-funded warrants sold in the private placement. This prospectus registers the total of 13,793,10455,944,850 shares of common stock for resale by the selling stockholders.

All information with respect to share ownership of each of the selling stockholders has been furnished by the respective selling stockholder. The shares being offered are being registered to permit public secondary trading of such shares and each selling stockholder may offer all or part of the shares it owns for resale from time to time in one or more transactions pursuant to this prospectus. To our knowledge, other than the relationships described herein, no selling stockholder or any of its affiliates has any family relationships with our officers, directors or controlling stockholders. Information in the table below is based on 44,358,09945,177,730 shares of our common stock outstanding on November 30, 2022.January 31, 2024.

If a selling stockholder is an affiliate of broker-dealers, it and any participating broker-dealers are deemed to be “underwriters” within the meaning of the Securities Act, and any commissions or discounts given to the selling stockholder or broker-dealer may be regarded as underwriting commissions or discounts under the Securities Act.

The term “selling stockholder” also includes any transferees, pledgees, donees, or other successors in interest to the selling stockholder. To our knowledge, each selling stockholder has sole voting and investment power with respect to its shares of common stock, except as otherwise indicated in the footnotes to the table below. We will file a supplement to this prospectus (or a post-effective amendment hereto, if necessary) to name successors to selling stockholders who are able to use this prospectus to resell the shares of common stock registered hereby.

_________________

^* Less than 1%

¹ⁱ This table is based upon information supplied by the selling stockholders, which information may not be accurate as of the date hereof. We have determined beneficial ownership in accordance with the rules of the SEC and generally includes voting or investment power with respect to securities. Except as indicated by the footnotes below, we believe, based on the information furnished to us, that the selling stockholders named in the table above have sole voting and investment power with respect to all shares of common stock that they beneficially own, subject to applicable community property laws. Shares of common stock issuable upon exercise of the pre-funded warrants as well as shares of common stock subject to warrants, options or rights currently exercisable, or exercisable within 60 days of November 30, 2022January 31, 2024, are counted as beneficially owned by the selling stockholder.

²ⁱⁱ Represents all of the shares of our common stock that a selling stockholder may offer and sell from time to time under this prospectus, including shares issuable upon the exercise of pre-funded warrants issued in the private placement, and assumes all of the shares of common stock offered are sold. ”

³ⁱⁱⁱ Based on 44,358,09945,177,730 shares of our common stock outstanding on November 30, 2022.January 31, 2024.

⁴¹ Bob Atchinson and Phillip Gross are the managing members of Adage Capital Advisors, L.L.C., which is the managing member of Adage Capital Partners GP, L.L.C., which is the general partner of Adage Capital Partners, L.P., and each such person or entity, as the case may be, may be deemed the beneficial owner of the shares of common stock held by Adage Capital Partners L.P. The business address of Adage Capital Partners L.P. is 200 Clarendon Street, 52nd Floor, Boston, MA 02116.

⁵² Consists of 3,861,2904,567,717 shares of common stock and 1,026,762 shares underlying pre-funded warrants held in the aggregate by RTW Master Fund, Ltd., RTW Innovation Master Fund, Ltd., and RTW Venture Fund Limited (collectively, theBiotech Opportunities Ltd (the “RTW Funds”) as of November 30, 2022.. RTW Investments, LP is(“RTW”), in its capacity as the investment manager of the RTW Funds, has the power to vote and the power to direct the disposition of the shares held by the RTW Funds. Accordingly, RTW may be deemed to be the beneficial owner of such securities. Roderick Wong, M.D. is, as the Managing Partner and Chief Investment Officer of RTW, Investments, L.P. Eachhas the power to direct the vote and disposition of the RTW Funds andsecurities held by RTW. Dr. Wong disclaims any beneficial ownership of the shares of common stock directly held by the RTW Funds, except to the extent of its or his pecuniary interest therein. The address for eachand principal office of these entities and individualsRTW Investments, LP is 40 10th Avenue, Floor 7, New York, NY 10014, and the address of Dr. Wong and each of the RTW Funds is c/o RTW Investments, LP, 40 10th Avenue, Floor 7, New York, NY 10014.

⁶³ Consists of 4,665,158 shares of common stock and 4,496,000 shares underlying pre-funded warrants held by Biotechnology Value Fund, L.P. BVF I GP LLC is the general partner of Biotechnology Value Fund, L.P. (“BVF”) and, accordingly, may be deemed to beneficially own the sharessecurities held by BVF.Biotechnology Value Fund, L.P. BVF GP Holdings LLC is the sole member of BVF I GP LLC and, accordingly, may be deemed to beneficially own the sharessecurities held by BVF.Biotechnology Value Fund, L.P. BVF Partners L.P., as the investment manager of BVF,Biotechnology Value Fund, L.P., may be deemed to beneficially own the sharessecurities held by BVF.Biotechnology Value Fund, L.P. BVF Inc., as the general partner of BVF Partners L.P., and Mark N. Lampert, as directoran officer and officerdirector of BVF, Inc., may be deemed to beneficially own the securities beneficially owned by Biotechnology Value Fund, L.P. BVF I GP LLC disclaims beneficial ownership of the shares beneficially owned by BVF.Biotechnology Value Fund, L.P. BVF GP Holdings LLC disclaims beneficial ownership of the shares beneficially owned by Biotechnology Value Fund, L.P. Each of BVF Partners L.P., BVF Inc., and Mr. Lampert disclaims beneficial ownership of the shares beneficially owned by Biotechnology Value Fund, L.P. The business address of BVFBiotechnology Value Fund, L.P. is 44 Montgomery Street, 40th Floor, San Francisco, CA 94104.

⁷⁴ Consists of 3,646,658 shares of common stock and 3,514,428 shares underlying pre-funded warrants held by Biotechnology Value Fund II, L.P. BVF II GP LLC is the general partner of Biotechnology Value Fund II, L.P. (“BVF2”) and, accordingly, may be deemed to beneficially own the sharessecurities held by BVF2.Biotechnology Value Fund II, L.P. BVF GP Holdings LLC is the sole member of BVF II GP LLC and, accordingly, may be deemed to beneficially own the sharessecurities held by BVF2.Biotechnology Value Fund II, L.P. BVF Partners L.P., as the investment manager of BVF2,Biotechnology Value Fund II, L.P., may be deemed to beneficially own the sharessecurities held by BVF2.Biotechnology Value Fund II, L.P. BVF Inc., as the general partner of BVF Partners L.P., and Mark N. Lampert, as directoran officer and officerdirector of BVF Inc., may be deemed to beneficially own the securities beneficially owned by Biotechnology Value Fund II, L.P. BVF II GP LLC disclaims beneficial ownership of the shares beneficially owned by BVF2.Biotechnology Value Fund II, L.P. BVF GP Holdings LLC disclaims beneficial ownership of the shares beneficially owned by Biotechnology Value Fund II, L.P. Each of BVF Partners L.P., BVF Inc., and Mr. Lampert disclaims beneficial ownership of the shares beneficially owned by Biotechnology Value Fund II, L.P. The business address of BVF2Biotechnology Value Fund II, L.P. is 44 Montgomery Street, 40th Floor, San Francisco, CA 94104.

⁸⁵ Consists of 461,173 shares of common stock and 444,452 shares underlying pre-funded warrants held by Biotechnology Value Trading Fund OS LP. BVF Partners OS Ltd. is the general partner of Biotechnology Value Trading Fund OS LP (“Trading Fund OS”) and, accordingly, may be deemed to beneficially own the sharessecurities beneficially owned by Biotechnology Value Trading Fund OS.OS LP. BVF Partners L.P., as the sole member of BVF Partners OS Ltd., may be deemed to beneficially own the sharessecurities held by Biotechnology Value Trading Fund OS.OS LP. BVF Inc., as the general partner of BVF Partners L.P., and Mark N. Lampert, as directoran officer and officerdirector of BVF Inc., may be deemed to beneficially own the sharessecurities beneficially owned by Trading Fund OS. The business address ofBiotechnology Value Trading Fund OS is PO Box 309 Ugland House, Grand Cayman, KY1-1104, Cayman Islands.

⁹LP. BVF Partners L.P. as the investment managerOS Ltd. disclaims beneficial ownership of MSI BVF SPV, LLC (“MSI”) may be deemed to beneficially own the shares held by MSI. BVF Inc., as the general partner of BVF Partners L.P. and Mark N. Lampert as director and officer of BVF Inc., may be deemed to beneficially own the shares beneficially owned by MSI.Biotechnology Value Trading Fund OS LP. Each of BVF Partners L.P., BVF Inc., and Mr. Lampert disclaims beneficial ownership of the shares beneficially owned by Biotechnology Value Trading Fund OS LP. The business address of MSIBiotechnology Value Trading Fund OS LP is 44 Montgomery Street, 40th Floor, San Francisco, CA 94104.

¹⁰⁶ Consists of 4,022,989129,983 shares of common stock issuable uponand 125,271 shares underlying pre-funded warrants held by MSI BVF SPV, LLC. BVF Partners L.P., as the exerciseinvestment manager of pre-funded warrants.MSI BVF SPV, LLC, may be deemed to beneficially own the securities held by MSI BVF SPV, LLC. BVF Inc., as the general partner of BVF Partners L.P., and Mark N. Lampert, as an officer and director of BVF Inc., may be deemed to beneficially own the securities beneficially owned by MSI BVF SPV, LLC. Each of BVF Partners L.P., BVF Inc., and Mr. Lampert disclaims beneficial ownership of the shares beneficially owned by MSI BVF SPV, LLC. The business address of Deep Track Biotechnology Master Fund, Ltd.MSI BVF SPV, LLC is 200 Greenwich Ave., 3rd44 Montgomery Street, 40th Floor, Greenwich, CT 06830.San Francisco, CA 94104.

¹¹⁷ Great Point Partners, 683 Capital GP, LLC is the investment manager for Biomedical Offshore Value Fund, Ltd.general partner of 683 Capital Partners, LP, and accordingly,Joseph Patt, as member of 683 Capital GP, LLC, may be deemed to beneficially own the shares held by Biomedical Offshore Value Fund, Ltd. Each of Dr. Jeffrey R. Jay, M.D., as senior managing member of Great Point683 Capital Partners, andLP. Mr. Ortav Yehudai, as Managing Director of Great Point, has voting and investment power with respect to the shares, and therefore may be deemed to be the beneficial owner of the shares. The business address for Great Point Partners, LLC and Biomedical Offshore Value Fund, Ltd. Is 165 Mason Street, 3rd Floor, Greenwich, CT 06830.

¹² Great Point Partners, LLC is the investment manager for Biomedical Value Fund, L.P. and, accordingly, may be deemed to beneficially own the shares held by Biomedical Value Fund, L.P. Each of Dr. Jeffrey R. Jay, M.D., as senior managing member of Great Point Partners, and Mr. Ortav Yehudai, as Managing Director of Great Point, has voting and investment power with respect to the shares, and therefore may be deemed to be the beneficial owner of the shares. The business address for Great Point Partners, LLC and Biomedical Value Fund, L.P. Is 165 Mason Street, 3rd Floor, Greenwich, CT 06830.

¹³ Consists of 1,800,000 shares of common stock and pre-funded warrants to purchase 1,073,563 additional shares of common stock. Commodore Capital Master LP has shared investment and voting power over these shares with its investment manager, Commodore Capital LP, which may be deemed to beneficially own these securities. The business address of Commodore Capital Master LP and Commodore Capital LP is 767 Fifth Avenue, Floor 12, New York, NY 10153.

¹⁴ RA Capital Management, L.P. is the investment manager for RA Capital Healthcare Fund, L.P. (“RACHF”). The general partner of RA Capital Management, L.P. is RA Capital Management GP, LLC, of which Peter Kolchinsky and Rajeev Shah are the managing members. Each of Mr. Kolchinsky and Mr. Shah may be deemed to have voting and investment power over the shares held by RACHF. Mr. Kolchinsky and Mr. Shah disclaimPatt disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein. The business address of the persons and entities set forth in this footnote is 200 Berkeley Street, 18th Floor, Boston, MA 02116.

¹⁵ Logos Globaltherein (if any). 683 Capital Management, LP, is investment manager and attorney-in-fact for Logos Global Master Fund LP and, accordingly, may be deemed to beneficially own the shares of common stock held by Logos Global Master Fund LP. The business address of Logos Global Master Fund LP and Logos Global Management LP is 1 Letterman Drive, Building C, Suite C3-350, San Francisco, CA 94129.

¹⁶ Logos Opportunities II GP, LLC is the general partnerinvestment manager of Logos Opportunities Fund III683 Capital Partners, LP, and accordingly,Ari Zweiman is the managing member of 683 Capital Management, LLC. As a result, each of 683 Capital Management, LLC and Mr. Zweiman may be deemed to beneficially own the shares of common stock held by Logos Opportunities Fund III LP. The business address Logos Opportunities Fund III LP and Logos Opportunities II GP, LLC is 1 Letterman Drive, Building C, Suite C3-350, San Francisco, CA 94129.

¹⁷ These shares are owned directly by Sphera Biotech Master Fund LP, which has delegated its investment management authority to Sphera Global Healthcare Management Ltd. Accordingly, Sphera Global Healthcare Management Ltd. may be deemed to beneficially these shares. The business address of Sphera Global Biotech Master Fund LP and Sphera Global Healthcare Management Ltd. Is 4 Yitzhak Sadeh, Tel Aviv, Israel 6777520.

¹⁸ These shares are owned directly by Sphera Global Healthcare Master Fund, which has delegated its investment management authority to Sphera Global Healthcare Management Ltd. Accordingly, Sphera Global Healthcare Management Ltd. may be deemed to beneficially these shares. The business address of Sphera Global Healthcare Master Fund and Sphera Global Healthcare Management Ltd. Is 4 Yitzhak Sadeh, Tel Aviv, Israel 6777520.

¹⁹ Invus Public Equities Advisors, LLC controls Invus Public Equities, L.P., as its general partner and, accordingly, mayalso be deemed to beneficially own the shares held by Invus Public Equities, L.P..683 Capital Partners, LP. Each of 683 Capital Management, LLC and Mr. Zweiman disclaims beneficial ownership of such shares, except to the extent of its or his pecuniary interest therein (if any). The business address for Invus Public Equities, L.P. and Invus Public Equities Advisors, LLCof 683 Capital Partners, LP is 750 Lexington Avenue, 30th Floor,1700 Broadway Suite 4200, New York, NY 10022..10019.

²⁰⁸ Parkman Healthcare Partners Such shares may be deemed to be beneficially owned by Janus Henderson Investors US LLC provides(“Janus”), an investment advisory servicesadviser registered under the Investment Advisers Act of 1940, who acts as investment adviser for Janus Henderson Biotech Innovation Master Fund Limited (the “Fund”) and has the ability to fundsmake decisions with respect to the voting or disposition of the shares subject to the oversight of the board of directors of the Fund. Under the terms of its management contract with the Fund, Janus has overall responsibility for directing the investments of the Fund in accordance with the Fund’s investment objective, policies and clients that hold an aggregatelimitations. The Fund has one or more portfolio managers appointed by and serving at the pleasure of 459,770Janus who makes decisions with respect to the disposition of the shares of common stock offered hereby. The portfolio managers of Immunic, Inc. Gregory Martinezthe Fund are Andrew Acker, Daniel S. Lyons and Agustin Mohedas. The business address of the Fund is c/o Janus Henderson Investors US LLC, 151 Detroit Street, Denver, CO 80206.

⁹ Soleus Private Equity GP III, LLC is the sole general partner of Soleus Private Equity Fund III, L.P. Soleus Private Equity GP III, LLC holds voting and dispositive power over the shares held by Soleus Private Equity Fund III, L.P. Soleus PE GP III, LLC is the sole manager of Soleus Private Equity GP III, LLC. Guy Levy is the sole managing member of Soleus PE GP III, LLC. Each of Mr. Guy Levy, Soleus PE GP III, LLC, and Soleus Private Equity GP III, LLC disclaims beneficial ownership of these securities held by Soleus Private Equity Fund III, L.P., except to the extent of their respective pecuniary interests therein. The business address of Soleus Private Equity Fund III, L.P. is 104 Field Point Road, 2nd Floor, Greenwich, CT 06830.

¹⁰ Soleus Capital, LLC is the sole general partner of Soleus Capital Master Fund, L.P. and thus holds voting and dispositive power over the shares held by Soleus Capital Master Fund, L.P. Soleus Capital Group, LLC is the sole managing member of Soleus Capital, LLC. Guy Levy is the sole managing member of Soleus Capital Group, LLC. Each of Soleus Capital Group, LLC, Soleus Capital, LLC, and Mr. Guy Levy disclaims beneficial ownership of these securities held by Soleus Capital Master Fund, L.P., except to the extent of their respective pecuniary interests therein. The business address of Soleus Capital Master Fund, L.P. is 104 Field Point Road, 2nd Floor, Greenwich, CT 06830.

¹¹ Altium Capital Management, LP, the investment manager of Altium Growth Fund, LP, has voting and investment power over these securities. Jacob Gottlieb is the managing member of Parkman Healthcare PartnersAltium Capital Growth GP, LLC, which is the general partner of Altium Growth Fund, LP. Each of Altium Growth Fund, LP and Jacob Gottlieb disclaims beneficial ownership over these securities. The principal address of Altium Capital Management, LP is 152 West 57th Street, 20th Floor, New York, NY 10019.

¹² UBS O’Connor LLC is the investment manager of Nineteen77 Global Multi-Strategy Alpha Master Limited. Blake Hiltabrand, as Global Head of UBS O’Connor LLC, and Bernard Ahkong and Casey Talbot, as Co-Chief Investment Officers of UBS O’Connor LLC’s Global Multi-Strategy portfolio, may therefore be deemed to have indirect beneficial ownershipthe power to vote or dispose of the securities ownedshares held by the funds or clientsNineteen77 Global Multi-Strategy Alpha Master Limited. Each of Parkman Healthcare Partners LLC by virtue of his ability to control Parkman Healthcare Partners LLC. Gregory MartinezMr. Hiltabrand, Mr. Ahkong, and Mr. Talbot disclaims beneficial ownership of the securities indirectly held by Parkman Healthcare Partners LLC,shares, except to the extent of his pecuniary interest therein if any.(if any). In addition, Doyle Horn, Director at UBS O’Connor LLC, and Jeff Richmond, Executive Director at UBS O’Connor LLC, may be deemed to have voting or investment control over the shares held by Nineteen77 Global Multi-Strategy Alpha Master Limited. Each of Mr. Horn and Mr. Richmond disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein (if any). The business address of Parkman Healthcare PartnersNineteen77 Global Multi-Strategy Alpha Master Limited is c/o UBS O’Connor LLC, is 700 Canal Street, 2ndOne North Wacker Drive, 31st Floor, Stamford, CT 06902..Chicago, IL 60606.

²¹¹³ Pursuant to an investment management agreement, Point72 Asset Management, L.P. (“Point72 Asset Management”) maintains investment Consists of 5,252,754 shares of common stock and voting power with respect to the securities936,124 shares underlying pre-funded warrants held by certainAvidity Private Master Fund I LP. The general partner of Avidity Private Master Fund I LP is Avidity Capital Partners Fund (GP) LP, whose general partner is Avidity Capital Partners (GP) LLC. Avidity Partners Management LP is the investment funds it manages, including Point72 Associates,manager of Avidity Private Master Fund I LP. Avidity Partners Management (GP) LLC (“Point72 Associates”). Point72 Capital Advisors, Inc. is the general partner of Point72 Asset Management. Steven A. Cohen controls eachAvidity Partners Management LP. David Witzke and Michael Gregory are the managing members of Point72 AssetAvidity Capital Partners (GP) LLC and Avidity Partners Management (GP) LLC. Each of the foregoing entities and Point72 Capital Advisors, Inc. As such, each of Point72 Asset Management, Point72 Capital Advisors, Inc. and Mr. Cohenindividuals may be deemed to beneficially own the sharessecurities held by Point72 Associates. Each of Point72 Asset Management, Point72 Capital Advisors, Inc.Avidity Private Master Fund I LP, and Mr. Coheneach such entity and individual disclaims beneficial ownership over the securities, except to the extent of any such shares.its or his pecuniary interest therein (if any). The business address of the principal business office of Point72 Associates, Point72 Asset Management, Point72 Capital Advisors, Inc. and Mr. CohenAvidity Private Master Fund I LP is c/o Point 72 Asset Management, L.P., 72 Cummings Point Road, Stamford, CT 06902.2828 N. Harwood Street, Suite 1220, Dallas, TX 75201.

²²¹⁴ Consists of 3,650,218 shares of common stock and 650,527 shares underlying pre-funded warrants held by Avidity Master Fund LP. The general partner of Vivo OpportunityAvidity Master Fund Holdings, L.P.LP is Vivo Opportunity,Avidity Capital Partners Fund (GP) LP, whose general partner is Avidity Capital Partners (GP) LLC. Avidity Partners Management LP is the investment manager of Avidity Master Fund LP. Avidity Partners Management (GP) LLC is the general partner of Avidity Partners Management LP. David Witzke and Michael Gregory are the managing members of Avidity Capital Partners (GP) LLC and as such,Avidity Partners Management (GP) LLC. Each of the foregoing entities and individuals may be deemed to beneficially own the sharessecurities held by Vivo OpportunityAvidity Master Fund Holdings, L.P.LP, and each such entity and individual disclaims beneficial ownership over the securities, except to the extent of its or his pecuniary interest therein (if any). The business address of Vivo Opportunity Fund Holdings, L.P. is 192 Lytton Avenue, Palo Alto, CA 94301.

²³ Woodline Partners LP serves as the investment manager of WoodlineAvidity Master Fund LP is 2828 N. Harwood Street, Suite 1220, Dallas, TX 75201.

¹⁵ Boothbay Diversified Alpha Master Fund, LP is managed by Boothbay Fund Management LLC. Daniel Bloom, as Chief Financial Officer and may be deemed to be the beneficial ownerChief Commercial Officer of Boothbay Fund Management LLC, has voting or investment control over the shares held by Boothbay Diversified Alpha Master Fund, LP. Each of common stock. Woodline Partners LPBoothbay Fund Management LLC and Mr. Bloom disclaims any beneficial ownership of these shares. The addressany such shares, except to the extent of Woodlineits or his pecuniary interest therein (if any). As cofounder of Ikarian Capital, LLC, an affiliate of Boothbay Diversified Alpha Master Fund, LP, Vikram Khanna has voting or investment control over Boothbay Diversified Alpha Master Fund, LP. Mr. Khanna disclaims beneficial ownership of any such shares, except to the extent of his pecuniary interest therein (if any). The business address of Boothbay Diversified Alpha Master Fund LP is 4 Embarcadero Center, Suite 3450, San Francisco, CA 94111.140 East 45th Street, 14th Floor, New York, NY 10017.

¹⁶ Boothbay Absolute Return Strategies, LP is managed by Boothbay Fund Management LLC. Daniel Bloom, as Chief Financial Officer and Chief Commercial Officer of Boothbay Fund Management LLC, has voting or investment control over the shares held by Boothbay Absolute Return Strategies, LP. Each of Boothbay Fund Management LLC and Mr. Bloom disclaims beneficial ownership of any such shares, except to the extent of its or his pecuniary interest therein (if any). As cofounder of Ikarian Capital, LLC, an affiliate of Boothbay Absolute Return Strategies, LP, Vikram Khanna has voting or investment control over the shares held by Boothbay Absolute Return Strategies, LP. Mr. Khanna disclaims beneficial ownership of any such shares, except to the extent of his pecuniary interest therein (if any). The business address of Boothbay Absolute Return Strategies, LP is 140 East 45th Street, 14th Floor, New York, NY 10017.

¹⁷ Ikarian Healthcare Master Fund, LP is managed by Ikarian Capital, LLC. Neil T. Shahrestani, as Chief Executive Officer of Ikarian Capital, LLC, has voting or investment control over the shares held by Ikarian Healthcare Master Fund, LP. Each of Ikarian Capital, LLC and Mr. Shahrestani disclaims beneficial ownership of any such shares, except to the extent of its or his pecuniary interest therein (if any). As cofounder of Ikarian Capital, LLC, Vikram Khanna has voting or investment control over the shares held by Ikarian Healthcare Master Fund, LP. Mr. Khanna disclaims beneficial ownership of any such shares, except to the extent of his pecuniary interest therein (if any). The business address of Ikarian Healthcare Master Fund, LP is 100 Crescent Court, Suite 1620, Dallas, TX 75201.

We may require the selling stockholders to suspend the sales of the common stock offered by this prospectus upon the occurrence of any event that makes any statement in this prospectus or the related registration statement untrue in any material respect, or that requires the changing of statements in these documents in order to make statements in those documents not misleading.

Information concerning the selling stockholders may change from time to time and any changed information will be set forth in prospectus supplements if and when necessary.

PLAN OF DISTRIBUTION

The selling stockholders, including their respective pledgees, donees, transferees or other successors-in-interest, may from time to time offer some or all of the shares of common stock covered by this prospectus. To the extent required, this prospectus may be amended and supplemented from time to time to describe a specific plan of distribution.

The selling stockholders will not pay any of the costs, expenses and fees in connection with the registration of the shares of common stock covered by this prospectus, but each selling stockholder will pay any and all underwriting discounts, selling commissions and stock transfer taxes, if any, attributable to sales of shares by that selling stockholder. We will not receive any proceeds from the sale of the shares of our common stock covered by this prospectus.

Each of the selling stockholders may sell shares of common stock covered by this prospectus from time to time, and may also decide not to sell all or any of the shares of common stock that it is allowed to sell under this prospectus. The selling stockholders will act independently of us in making decisions regarding the timing, manner and size of each sale. These dispositions may be at fixed prices, at market prices prevailing at the time of sale, at prices related to such prevailing market prices, at varying prices determined at the time of sale, or at privately negotiated prices. Sales may be made by the selling stockholders in one or more types of transactions, which may include:

A selling stockholder may also resell all or a portion of its shares of common stock in open market transactions in reliance upon Rule 144 under the Securities Act, provided it meets the criteria and conforms to the requirements of Rule 144.

A selling stockholder may enter into sale, forward-sale and derivative transactions with third parties, or may sell securities not covered by this prospectus to third parties in privately negotiated transactions. If the applicable prospectus supplement indicates, in connection with those sale, forward-sale or derivative transactions, the third parties may sell securities covered by this prospectus or the applicable prospectus supplement, including in short sale transactions and by issuing securities that are not covered by this prospectus but are exchangeable for or represent beneficial interests in the common stock. The third parties also may use shares received under those sale, forward-sale or derivative arrangements, or shares pledged by a selling stockholder or borrowed from a selling stockholder or others to settle such third-party sales or to close out any related open borrowings of common stock. The third parties may deliver this prospectus in connection with any such transactions. Any third party in such sale transactions will be an underwriter and will be identified in the applicable prospectus supplement (or a post-effective amendment to the registration statement of which this prospectus is a part).

In addition, a selling stockholder may engage in hedging transactions with broker-dealers in connection with distributions of common stock or otherwise. In those transactions, broker-dealers may engage in short sales of securities in the course of hedging the positions they assume with a selling stockholder. A selling stockholder may also sell securities short and redeliver securities to close out such short positions. A selling stockholder may also enter into option or other transactions with broker-dealers which require the delivery of securities to the broker-dealer. The broker-dealer may then resell or otherwise transfer such securities pursuant to this prospectus. A selling stockholder also may loan or pledge shares, and the borrower or pledgee may sell or otherwise transfer the common stock so loaned or pledged pursuant to this prospectus. Such borrower or pledgee also may transfer those shares of common stock to investors in our securities or a selling stockholder’s securities or in connection with the offering of other securities not covered by this prospectus.

To the extent necessary, we may amend or supplement this prospectus from time to time to describe a specific plan of distribution. We will file a supplement to this prospectus, if required, upon being notified by a selling stockholder that any material arrangement has been entered into with a broker-dealer for the sale of shares of common stock through a block trade, offering or a purchase by a broker or dealer. The applicable prospectus supplement will set forth the specific terms of the offering, of, including:

In connection with sales of common stock covered hereby, a selling stockholder and any underwriter, broker-dealer or agent and any other participating broker-dealer that executes sales for a selling stockholder may be deemed to be an “underwriter” within the meaning of the Securities Act. Accordingly, any profits realized by such selling stockholder and any compensation earned by such underwriter, broker-dealer or agent may be deemed to be underwriting discounts and commissions. Because selling stockholders may be deemed to be “underwriters” under the Securities Act, selling stockholders must deliver this prospectus and any prospectus supplement in the manner required by the Securities Act. This prospectus delivery requirement may be satisfied through the facilities of Nasdaq in accordance with Rule 153 under the Securities Act.

We or selling stockholders may agree to indemnify any underwriters, broker-dealers and agents against or contribute to any payments the underwriters, broker-dealers or agents may be required to make with respect to, civil liabilities, including liabilities under the Securities Act. Underwriters, broker-dealers and agents and their affiliates are permitted to be customers of, engage in transactions with, or perform services for us and our affiliates or the selling stockholders or their respective affiliates in the ordinary course of business.

Selling stockholders will be subject to applicable provisions of Regulation M of the Exchange Act and the rules and regulations thereunder, which provisions may limit the timing of purchases and sales of any of the common stock by a selling stockholder. Regulation M may also restrict the ability of any person engaged in the distribution of the common stock to engage in market-making activities with respect to the common stock. These restrictions may affect the marketability of such common stock.

In order to comply with applicable securities laws of some states, the common stock may be sold in those jurisdictions only through registered or licensed brokers or dealers. In addition, in certain states shares of common stock may not be sold unless they have been registered or qualified for sale in the applicable state or an exemption from the registration or qualification requirements is available. In addition, any shares of common stock of a selling stockholder covered by this prospectus that qualify for sale pursuant to Rule 144 under the Securities Act may be sold in open market transactions under Rule 144, rather than pursuant to this prospectus.

LEGAL MATTERS

The validity of the shares of common stock offered by this prospectus will be passed upon by Dentons US LLP.

EXPERTS

The consolidated financial statements of Immunic, Inc. as of December 31, 20212023 and 20202022 and for each of the two years in the period ended December 31, 20212023 incorporated in this prospectus by reference to our Annual Report on Form 10-K for the year ended December 31, 2021,2023, have been so incorporated in reliance on the report of Baker Tilly US, LLP, an independent registered public accounting firm, given on the authority of said firm as experts in auditing and accounting.

WHERE YOU CAN FIND MORE INFORMATION

This prospectus forms part of a registration statement on Form S-3 that we filed with the SEC. This prospectus does not contain all of the information set forth in the registration statement and the exhibits to the registration statement or the documents incorporated by reference herein and therein. For further information with respect to us and the securities being offered under this prospectus, we refer you to the registration statement and the exhibits and schedules filed as a part of the registration statement and the documents incorporated by reference herein and therein. You should rely only on the information contained in this prospectus or incorporated by reference herein. We have not authorized anyone else to provide you with different information. We are not making an offer of these securities in any jurisdiction where the offer is not permitted. You should not assume that the information in this prospectus is accurate as of any date other than the date on the front page, regardless of the time of delivery of this prospectus or any sale of the securities offered hereby.

We file annual, quarterly and other reports, proxy and information statements and other information with the SEC. The SEC maintains a website that contains reports, proxy statements and other information regarding us. The address of the SEC website is www.sec.gov. We maintain a website at www.imux.com. The information contained on, or that can be accessed through, our website is not a part of this prospectus. Investors should not rely on any such information in deciding whether to purchase our common stock. We have included our website address in this prospectus solely as an inactive textual reference.

INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

The SEC’s rules allow us to “incorporate by reference” information into this prospectus, which means that we can disclose important information to you by referring you to another document filed separately with the SEC. The information incorporated by reference is deemed to be part of this prospectus, and subsequent information that we file with the SEC will automatically update and supersede that information. Any statement contained in a previously filed document incorporated by reference will be deemed to be modified or superseded for purposes of this prospectus to the extent that a statement contained in this prospectus modifies or replaces that statement.

We incorporate by reference our documents listed below and any future filings made by us with the SEC under Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended, which we refer to as the “Exchange Act” in this prospectus, between the date of this prospectus and the termination of the offering of the securities described in this prospectus. We are not, however, incorporating by reference any documents or portions thereof, whether specifically listed below or filed in the future, that are not deemed “filed” with the SEC, including our Compensation Committee report and performance graph or any information furnished pursuant to Items 2.02 or 7.01 of Form 8-K or related exhibits furnished pursuant to Item 9.01 of Form 8-K. This prospectus and any accompanying prospectus supplement incorporate by reference the documents set forth below that have previously been filed with the SEC:

You may request a free copy of any of the documents incorporated by reference in this prospectus (other than exhibits, unless they are specifically incorporated by reference in the documents) by writing or telephoning us at the following address:

Immunic, Inc.
Attn: Corporate Secretary
1200 Avenue of the Americas, Suite 200
New York, New York 10036

55,944,850 Shares

PROSPECTUS

                  , 2024

PART II
INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14. Other Expenses of Issuance and Distribution.

The following table sets forth an itemization of the various expenses, all of which we will pay, in connection with the issuance and distribution of the common stock being registered. All of the amounts shown are estimated except the Securities and Exchange Commission registration fee:

Item 15. Indemnification of Directors and Officers.

We are incorporated under the laws of the state of Delaware. Section 145(a) of the Delaware General Corporation Law (the “DGCL”) provides that a Delaware corporation may indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the right of the corporation) by reason of the fact that such person is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against expenses (including attorneys’ fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by the person in connection with such action, suit or proceeding if the person acted in good faith and in a manner the person reasonably believed to be in or not opposed to the best interests of the corporation, and, with respect to any criminal action or proceeding, had no reasonable cause to believe his or her conduct was unlawful.

Section 145(b) of the DGCL provides that a Delaware corporation may indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action or suit by or in the right of the corporation to procure a judgment in its favor by reason of the fact that such person is or was a director, officer, employee or agent of the corporation, or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, joint venture, trust or other enterprise, against expenses (including attorneys’ fees) actually and reasonably incurred by such person in connection with the defense or settlement of such action or suit if the person acted in good faith and in a manner the person reasonably believed to be in or not opposed to the best interests of the corporation, except that no indemnification shall be made in respect of any claim, issue or matter as to which such person shall have been adjudged to be liable to the corporation, unless and only to the extent that the Court of Chancery or the court in which such action or suit was brought shall determine that, despite the adjudication of liability but in view of all the circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which the court shall deem proper.

Further subsections of DGCL Section 145 provide that:

(1) to the extent a present or former director or officer of a corporation has been successful on the merits or otherwise in the defense of any action, suit or proceeding referred to in subsections (a) and (b) of Section 145 or in the defense of any claim, issue or matter therein, such person shall be indemnified against expenses, including attorneys’ fees, actually and reasonably incurred by such person in connection therewith;

(2) the indemnification and advancement of expenses provided for pursuant to Section 145 shall not be deemed exclusive of any other rights to which those seeking indemnification or advancement of expenses may be entitled under any bylaw, agreement, vote of stockholders or disinterested directors or otherwise; and

(3) the corporation shall have the power to purchase and maintain insurance on behalf of any person who is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against any liability asserted against such person and incurred by such person in any such capacity, or arising out of such person’s status as such, whether or not the corporation would have the power to indemnify such person against such liability under Section 145 of the DGCL.

Section 145 of the DGCL makes provision for the indemnification of officers and directors in terms sufficiently broad to indemnify our officers and directors under certain circumstances from liabilities (including reimbursement for expenses incurred) arising under the Securities Act. Our bylaws provide, in effect, that, to the fullest extent and under the circumstances permitted by Section 145 of the DGCL, we will indemnify any person (and the estate of any person) who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative, by reason of the fact that he or she is or was a director or officer of our company or is or was serving at our request as a director or officer of another corporation or enterprise. We may, in our discretion, similarly indemnify its employees and agents.

We have entered into indemnification agreements with our officers and directors.

Our certificate of incorporation relieves our directors from monetary damages to us or our stockholders for breach of such director’s fiduciary duty as a director to the fullest extent permitted by the DGCL. Under Section 102(b)(7) of the DGCL, a corporation may relieve its directors from personal liability to such corporation or its stockholders for monetary damages for any breach of their fiduciary duty as directors except (i) for a breach of the duty of loyalty, (ii) for acts or omissions not in good faith, or which involve intentional misconduct or a knowing violation of law, (iii) for willful or negligent violations of certain provisions in the DGCL imposing certain requirements with respect to stock repurchases, redemptions and dividends, or (iv) for any transactions from which the director derived an improper personal benefit.

We currently maintain an insurance policy which, within the limits and subject to the terms and conditions thereof, covers certain expenses and liabilities that may be incurred by directors and officers in connection with proceedings that may be brought against them as a result of an act or omission committed or suffered while acting as a director or officer of our company.

Item 16. Exhibits.

See the Exhibit Index attached to this registration statement and incorporated herein by this reference.

Item 17. Undertakings.

(a) The undersigned registrant hereby undertakes:

Provided, however, that paragraphs (a)(1)(i), (a)(1)(ii) and (a)(1)(iii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the registrant pursuant to section 13 or section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in the registration statement, or is contained in a form of prospectus filed pursuant to Rule 424(b) that is a part of the registration statement.

(b) The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing of the registrant’s annual report pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan’s annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(c) Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrants pursuant to the foregoing provisions described in Item 15, or otherwise, the registrants have been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrants of expenses incurred or paid by a director, officer or controlling person of any registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, each appropriate registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

EXHIBIT INDEX