The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
ABBVIE INC | COM | 00287Y109 | 41,248 | 366,194 | SH | DFND | 1,2 | 366,194 | 0 | 0 | |
ACHILLES THERAPEUTICS PLC | SPONSORED ADS | 00449L102 | 2,861 | 292,194 | SH | DFND | 1,2 | 292,194 | 0 | 0 | |
AFFIMED N V | COM | N01045108 | 10,852 | 1,276,702 | SH | DFND | 1,2 | 1,276,702 | 0 | 0 | |
AGIOS PHARMACEUTICALS INC | CALL | 00847X104 | 6,393 | 116,000 | SH | Call | DFND | 1,2 | 0 | 0 | 116,000 |
ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 1,700 | 150,000 | SH | DFND | 1,2 | 150,000 | 0 | 0 | |
ALLOT LTD | SHS | M0854Q105 | 5,477 | 276,187 | SH | DFND | 276,187 | 0 | 0 | ||
ALTIMMUNE INC | COM NEW | 02155H200 | 6,731 | 683,395 | SH | DFND | 1,2 | 683,395 | 0 | 0 | |
ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 10,538 | 192,728 | SH | DFND | 1,2 | 192,728 | 0 | 0 | |
AMAZON COM INC | COM | 023135106 | 13,970 | 4,061 | SH | DFND | 4,061 | 0 | 0 | ||
ANNEXON INC | COM | 03589W102 | 3,339 | 148,318 | SH | DFND | 1,2 | 148,318 | 0 | 0 | |
APOLLO STRATEGIC GROWTH CAPT | SHS CL A | G0411R106 | 714 | 73,055 | SH | DFND | 73,055 | 0 | 0 | ||
ARGENX SE | SPONSORED ADR | 04016X101 | 2,785 | 9,249 | SH | DFND | 1,2 | 9,249 | 0 | 0 | |
ARKO CORP | COM | 041242108 | 3,399 | 369,875 | SH | DFND | 369,875 | 0 | 0 | ||
ARYA SCIENCES ACQU CORP IV | CL A | G31659108 | 5,360 | 500,000 | SH | DFND | 1,2 | 500,000 | 0 | 0 | |
ASTRAZENECA PLC | SPONSORED ADR | 046353108 | 68,745 | 1,147,673 | SH | DFND | 1,2 | 1,147,673 | 0 | 0 | |
ATERIAN INC | COM | 02156U101 | 5,852 | 399,999 | SH | DFND | 399,999 | 0 | 0 | ||
ATERIAN INC | CALL | 02156U101 | 5,202 | 355,600 | SH | Call | DFND | 0 | 0 | 355,600 | |
AUDIOCODES LTD | ORD | M15342104 | 12,746 | 385,194 | SH | DFND | 385,194 | 0 | 0 | ||
BCLS ACQUISITION CORP | COM CL A | G0904B105 | 7,244 | 687,900 | SH | DFND | 1,2 | 687,900 | 0 | 0 | |
BEAM THERAPEUTICS INC | COM | 07373V105 | 3,659 | 28,425 | SH | DFND | 1,2 | 28,425 | 0 | 0 | |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 7,173 | 20,900 | SH | DFND | 1,2 | 20,900 | 0 | 0 | |
BIOGEN INC | COM | 09062X103 | 8,309 | 23,995 | SH | DFND | 1,2 | 23,995 | 0 | 0 | |
BIOGEN INC | CALL | 09062X103 | 17,313 | 50,000 | SH | Call | DFND | 1,2 | 0 | 0 | 50,000 |
C4 THERAPEUTICS INC | COM STK | 12529R107 | 19,624 | 518,611 | SH | DFND | 1,2 | 518,611 | 0 | 0 | |
CAESARSTONE LTD | ORD SHS | M20598104 | 9,508 | 644,146 | SH | DFND | 644,146 | 0 | 0 | ||
CELCUITY INC | COM | 15102K100 | 1,080 | 45,000 | SH | DFND | 1,2 | 45,000 | 0 | 0 | |
CENTURY THERAPEUTICS INC | COM | 15673T100 | 2,347 | 80,000 | SH | DFND | 1,2 | 80,000 | 0 | 0 | |
CEREVEL THERAPEUTICS HLDNG I | COM | 15678U128 | 236 | 9,212 | SH | DFND | 1,2 | 9,212 | 0 | 0 | |
CEREVEL THERAPEUTICS HLDNG I | *W EXP 06/09/202 | 15678U102 | 2,379 | 165,295 | SH | DFND | 1,2 | 165,295 | 0 | 0 | |
CLARIM ACQUISITION CORP | UNIT 99/99/9999 | 18049C207 | 1,478 | 148,886 | SH | DFND | 148,886 | 0 | 0 | ||
CM LIFE SCIENCES III INC | UNIT 04/30/2028 | 125841205 | 821 | 75,000 | SH | DFND | 1,2 | 75,000 | 0 | 0 | |
CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 11,953 | 634,088 | SH | DFND | 1,2 | 634,088 | 0 | 0 | |
CURIS INC | COM NEW | 231269200 | 4,747 | 588,264 | SH | DFND | 1,2 | 588,264 | 0 | 0 | |
CVRX INC | COM | 126638105 | 4,200 | 150,000 | SH | DFND | 1,2 | 150,000 | 0 | 0 | |
CYCLACEL PHARMACEUTICALS INC | COM | 23254L603 | 3,009 | 508,322 | SH | DFND | 1,2 | 508,322 | 0 | 0 | |
CYTEIR THERAPEUTICS INC | COM | 23284P103 | 2,675 | 125,000 | SH | DFND | 1,2 | 125,000 | 0 | 0 | |
DFP HEALTHCARE ACQUISITNS CO | COM CL A | 23343Q100 | 1,257 | 126,491 | SH | DFND | 1,2 | 126,491 | 0 | 0 | |
DYNE THERAPEUTICS INC | COM | 26818M108 | 7,779 | 369,714 | SH | DFND | 1,2 | 369,714 | 0 | 0 | |
E MERGE TECHNOLOGY ACQUISITI | COM CL A | 26873Y104 | 976 | 100,000 | SH | DFND | 100,000 | 0 | 0 | ||
ELEVATION ONCOLOGY INC | COM | 28623U101 | 407 | 30,000 | SH | DFND | 1,2 | 30,000 | 0 | 0 | |
ENPHASE ENERGY INC | CALL | 29355A107 | 42,235 | 230,000 | SH | Call | DFND | 0 | 0 | 230,000 | |
ESSA PHARMA INC | COM NEW | 29668H708 | 18,522 | 648,303 | SH | DFND | 1,2 | 648,303 | 0 | 0 | |
EUCRATES BIOMEDICAL ACQU COR | SHS | G3141W106 | 3,239 | 329,025 | SH | DFND | 1,2 | 329,025 | 0 | 0 | |
FACEBOOK INC | CL A | 30303M102 | 9,388 | 27,000 | SH | DFND | 27,000 | 0 | 0 | ||
FATE THERAPEUTICS INC | COM | 31189P102 | 14,346 | 165,299 | SH | DFND | 1,2 | 165,299 | 0 | 0 | |
FIVERR INTL LTD | ORD SHS | M4R82T106 | 5,214 | 21,500 | SH | DFND | 21,500 | 0 | 0 | ||
FIVERR INTL LTD | CALL | M4R82T106 | 19,157 | 79,000 | SH | Call | DFND | 0 | 0 | 79,000 | |
FRAZIER LIFESCIENCES ACQU CO | CL A SHS | G3710A105 | 1,237 | 126,687 | SH | DFND | 1,2 | 126,687 | 0 | 0 | |
FREQUENCY THERAPEUTICS INC | COM | 35803L108 | 2,741 | 275,160 | SH | DFND | 1,2 | 275,160 | 0 | 0 | |
GENERAC HLDGS INC | COM | 368736104 | 43,327 | 104,363 | SH | DFND | 104,363 | 0 | 0 | ||
GRACELL BIOTECHNOLOGIES INC | SPONSORED ADS | 38406L103 | 3,040 | 233,850 | SH | DFND | 1,2 | 233,850 | 0 | 0 | |
GRAPHITE BIO INC | COM | 38870X104 | 767 | 24,957 | SH | DFND | 1,2 | 24,957 | 0 | 0 | |
HEALTHCARE CAPITAL CORP | UNIT 12/31/2025 | 42228C200 | 1,962 | 196,610 | SH | DFND | 196,610 | 0 | 0 | ||
HEALTHCOR CATALIO ACQU CORP | CL A SHS | G44125105 | 1,970 | 200,000 | SH | DFND | 1,2 | 200,000 | 0 | 0 | |
I MAB | SPONSORED ADS | 44975P103 | 3,891 | 46,350 | SH | DFND | 1,2 | 46,350 | 0 | 0 | |
IDEAYA BIOSCIENCES INC | COM | 45166A102 | 7,027 | 334,794 | SH | DFND | 1,2 | 334,794 | 0 | 0 | |
IMMATICS N.V | *W EXP 07/01/202 | N44445117 | 344 | 100,000 | SH | DFND | 1,2 | 100,000 | 0 | 0 | |
INHIBRX INC | COM | 45720L107 | 5,204 | 189,083 | SH | DFND | 1,2 | 189,083 | 0 | 0 | |
INTELLIA THERAPEUTICS INC | COM | 45826J105 | 8,508 | 52,550 | SH | DFND | 1,2 | 52,550 | 0 | 0 | |
INVESCO EXCH TRADED FD TR II | CALL | 46138G706 | 18,759 | 210,000 | SH | Call | DFND | 0 | 0 | 210,000 | |
IONIS PHARMACEUTICALS INC | CALL | 462222100 | 7,443 | 186,600 | SH | Call | DFND | 1,2 | 0 | 0 | 186,600 |
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 9,852 | 378,642 | SH | DFND | 1,2 | 378,642 | 0 | 0 | |
ISHARES TR | PUT | 464287655 | 24,084 | 105,000 | SH | Put | DFND | 105,000 | 0 | 0 | |
ISHARES TR | PUT | 464287515 | 40,954 | 105,000 | SH | Put | DFND | 105,000 | 0 | 0 | |
IVERIC BIO INC | COM | 46583P102 | 3,155 | 500,000 | SH | DFND | 1,2 | 500,000 | 0 | 0 | |
JIYA ACQUISITION CORP | COM CL A | 47760M102 | 1,978 | 199,028 | SH | DFND | 1,2 | 199,028 | 0 | 0 | |
JOHNSON & JOHNSON | COM | 478160104 | 66,820 | 405,608 | SH | DFND | 1,2 | 405,608 | 0 | 0 | |
KORNIT DIGITAL LTD | SHS | M6372Q113 | 18,375 | 147,793 | SH | DFND | 147,793 | 0 | 0 | ||
KURA ONCOLOGY INC | COM | 50127T109 | 18,116 | 868,886 | SH | DFND | 1,2 | 868,886 | 0 | 0 | |
KYMERA THERAPEUTICS INC | COM | 501575104 | 12,605 | 259,895 | SH | DFND | 1,2 | 259,895 | 0 | 0 | |
LAVA THERAPEUTICS NV | SHS | N51517105 | 2,343 | 215,359 | SH | DFND | 1,2 | 215,359 | 0 | 0 | |
LEFTERIS ACQUISITION CORP | COM CL A | 52470X109 | 1,116 | 114,428 | SH | DFND | 114,428 | 0 | 0 | ||
LILLY ELI & CO | COM | 532457108 | 41,748 | 181,895 | SH | DFND | 1,2 | 181,895 | 0 | 0 | |
LIONHEART ACQUISITION CORP I | COM CL A | 53625R104 | 986 | 99,859 | SH | DFND | 99,859 | 0 | 0 | ||
LIVEPERSON INC | COM | 538146101 | 14,229 | 225,000 | SH | DFND | 225,000 | 0 | 0 | ||
MAGIC SOFTWARE ENTERPRISES L | ORD | 559166103 | 259 | 15,976 | SH | DFND | 15,976 | 0 | 0 | ||
MERCK & CO INC | COM | 58933Y105 | 60,085 | 772,601 | SH | DFND | 1,2 | 772,601 | 0 | 0 | |
MERCK & CO INC | PUT | 58933Y105 | 60,085 | 772,600 | SH | Put | DFND | 1,2 | 772,600 | 0 | 0 |
MERUS N V | COM | N5749R100 | 6,037 | 286,506 | SH | DFND | 1,2 | 286,506 | 0 | 0 | |
MICROSOFT CORP | COM | 594918104 | 18,295 | 67,536 | SH | DFND | 67,536 | 0 | 0 | ||
MIRATI THERAPEUTICS INC | COM | 60468T105 | 7,642 | 47,309 | SH | DFND | 1,2 | 47,309 | 0 | 0 | |
MONTE ROSA THERAPEUTICS INC | COM | 61225M102 | 2,270 | 100,000 | SH | DFND | 1,2 | 100,000 | 0 | 0 | |
NAUTILUS BIOTECHNOLOGY INC | COM | 63909J108 | 8,080 | 800,000 | SH | DFND | 1,2 | 800,000 | 0 | 0 | |
NICE LTD | SPONSORED ADR | 653656108 | 19,001 | 76,786 | SH | DFND | 76,786 | 0 | 0 | ||
NICE SYS INC | NOTE 1.250% 1/1 | 65366HAB9 | 731 | 250,000 | SH | DFND | 250,000 | 0 | 0 | ||
NKARTA INC | COM | 65487U108 | 8,001 | 252,478 | SH | DFND | 1,2 | 252,478 | 0 | 0 | |
NURIX THERAPEUTICS INC | COM | 67080M103 | 6,477 | 244,157 | SH | DFND | 1,2 | 244,157 | 0 | 0 | |
OMEGA ALPHA SPAC | CL A | G6749V107 | 995 | 100,000 | SH | DFND | 1,2 | 100,000 | 0 | 0 | |
ONCORUS INC | COM | 68236R103 | 12,331 | 893,548 | SH | DFND | 1,2 | 893,548 | 0 | 0 | |
ONTO INNOVATION INC | COM | 683344105 | 7,855 | 107,548 | SH | DFND | 107,548 | 0 | 0 | ||
ORCHARD THERAPEUTICS PLC | ADS | 68570P101 | 5,999 | 1,366,564 | SH | DFND | 1,2 | 1,366,564 | 0 | 0 | |
OUTLOOK THERAPEUTICS INC | *W EXP 02/18/202 | 69012T115 | 49 | 129,500 | SH | DFND | 1,2 | 129,500 | 0 | 0 | |
PERRIGO CO PLC | SHS | G97822103 | 2,407 | 52,500 | SH | DFND | 52,500 | 0 | 0 | ||
PLAYTIKA HLDG CORP | COM | 72815L107 | 3,576 | 150,000 | SH | DFND | 150,000 | 0 | 0 | ||
PLIANT THERAPEUTICS INC | COM | 729139105 | 1,485 | 51,000 | SH | DFND | 1,2 | 51,000 | 0 | 0 | |
PMV PHARMACEUTICALS INC | COM | 69353Y103 | 2,872 | 84,074 | SH | DFND | 1,2 | 84,074 | 0 | 0 | |
PRAXIS PRECISION MEDICINES I | COM | 74006W108 | 1,382 | 75,600 | SH | DFND | 1,2 | 75,600 | 0 | 0 | |
PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 13,597 | 302,965 | SH | DFND | 1,2 | 302,965 | 0 | 0 | |
REPARE THERAPEUTICS INC | COM | 760273102 | 3,130 | 100,391 | SH | DFND | 1,2 | 100,391 | 0 | 0 | |
RESEARCH ALLIANCE CORP II | COM CL A | 760873109 | 6,000 | 600,000 | SH | DFND | 1,2 | 600,000 | 0 | 0 | |
SANOFI | SPONSORED ADR | 80105N105 | 44,413 | 843,400 | SH | DFND | 1,2 | 843,400 | 0 | 0 | |
SARISSA CAPITAL ACQUISITN CO | CL A | G7823W102 | 237 | 23,900 | SH | DFND | 1,2 | 23,900 | 0 | 0 | |
SELECT SECTOR SPDR TR | PUT | 81369Y803 | 31,009 | 210,000 | SH | Put | DFND | 210,000 | 0 | 0 | |
SENTINELONE INC | CL A | 81730H109 | 2,907 | 68,400 | SH | DFND | 68,400 | 0 | 0 | ||
SHATTUCK LABS INC | COM | 82024L103 | 7,949 | 274,214 | SH | DFND | 1,2 | 274,214 | 0 | 0 | |
SIGILON THERAPEUTICS INC | COM | 82657L107 | 3,865 | 360,239 | SH | DFND | 1,2 | 360,239 | 0 | 0 | |
SILVERBACK THERAPEUTICS INC | COM | 82835W108 | 5,371 | 173,891 | SH | DFND | 1,2 | 173,891 | 0 | 0 | |
SINGULAR GENOMICS SYSTEMS IN | COM | 82933R100 | 1,480 | 53,867 | SH | DFND | 1,2 | 53,867 | 0 | 0 | |
SOLAREDGE TECHNOLOGIES INC | COM | 83417M104 | 8,899 | 32,200 | SH | DFND | 32,200 | 0 | 0 | ||
SPDR SER TR | PUT | 78464A870 | 84,625 | 625,000 | SH | Put | DFND | 1,2 | 625,000 | 0 | 0 |
SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 16,080 | 195,117 | SH | DFND | 1,2 | 195,117 | 0 | 0 | |
STOKE THERAPEUTICS INC | COM | 86150R107 | 7,847 | 233,135 | SH | DFND | 1,2 | 233,135 | 0 | 0 | |
SUNRUN INC | COM | 86771W105 | 4,016 | 72,000 | SH | DFND | 72,000 | 0 | 0 | ||
SUTRO BIOPHARMA INC | COM | 869367102 | 5,481 | 294,825 | SH | DFND | 1,2 | 294,825 | 0 | 0 | |
SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 9,395 | 547,187 | SH | DFND | 1,2 | 547,187 | 0 | 0 | |
TAILWIND INTERNATNAL ACQ COR | UNIT 99/99/9999 | G8662F127 | 483 | 48,342 | SH | DFND | 48,342 | 0 | 0 | ||
TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | 8,245 | 832,878 | SH | DFND | 832,878 | 0 | 0 | ||
TEVA PHARMACEUTICAL INDS LTD | CALL | 881624209 | 18,909 | 1,910,000 | SH | Call | DFND | 0 | 0 | 1,910,000 | |
THERAPEUTICS ACQUISITION COR | COM CL A | 88339T103 | 10,378 | 1,009,497 | SH | DFND | 1,2 | 1,009,497 | 0 | 0 | |
TREMOR INTL LTD | ADS | 89484T104 | 2,985 | 150,000 | SH | DFND | 150,000 | 0 | 0 | ||
TURMERIC ACQUISITION CORP | CL A | G9127T108 | 2,170 | 219,440 | SH | DFND | 1,2 | 219,440 | 0 | 0 | |
TWILIO INC | CL A | 90138F102 | 10,445 | 26,500 | SH | DFND | 26,500 | 0 | 0 | ||
TWIST BIOSCIENCE CORP | COM | 90184D100 | 2,399 | 18,000 | SH | DFND | 1,2 | 18,000 | 0 | 0 | |
UNIQURE NV | SHS | N90064101 | 5,298 | 172,000 | SH | DFND | 1,2 | 172,000 | 0 | 0 | |
VARONIS SYS INC | COM | 922280102 | 12,562 | 218,013 | SH | DFND | 218,013 | 0 | 0 | ||
VERINT SYS INC | COM | 92343X100 | 6,761 | 150,000 | SH | DFND | 150,000 | 0 | 0 | ||
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 5,240 | 801,256 | SH | DFND | 1,2 | 801,256 | 0 | 0 | |
VINCERX PHARMA INC | COM NEW | 92731L106 | 2,955 | 227,450 | SH | DFND | 1,2 | 227,450 | 0 | 0 | |
VISTAGEN THERAPEUTICS INC | COM NEW | 92840H202 | 12,854 | 4,080,673 | SH | DFND | 1,2 | 4,080,673 | 0 | 0 | |
WEREWOLF THERAPEUTICS INC | COM | 95075A107 | 12,049 | 706,294 | SH | DFND | 1,2 | 706,294 | 0 | 0 | |
WIX COM LTD | SHS | M98068105 | 1,655 | 5,700 | SH | DFND | 5,700 | 0 | 0 | ||
XENON PHARMACEUTICALS INC | COM | 98420N105 | 51,412 | 276,130 | SH | DFND | 1,2 | 276,130 | 0 | 0 | |
YUMANITY THERAPEUTICS INC | COM | 98872L102 | 1,343 | 115,298 | SH | DFND | 1,2 | 115,298 | 0 | 0 | |
ZAI LAB LTD | ADR | 98887Q104 | 17,335 | 97,946 | SH | DFND | 1,2 | 97,946 | 0 | 0 |