The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
ABBVIE INC | COM | 00287Y109 | 10,040,310 | 63,000 | SH | DFND | 1,2 | 63,000 | 0 | 0 | |
AEGLEA BIOTHERAPEUTICS INC | COM | 00773J103 | 187,479 | 646,478 | SH | DFND | 1,2 | 646,478 | 0 | 0 | |
ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 1,544,000 | 200,000 | SH | DFND | 1,2 | 200,000 | 0 | 0 | |
ALTIMMUNE INC | COM NEW | 02155H200 | 1,266,000 | 300,000 | SH | DFND | 1,2 | 300,000 | 0 | 0 | |
AMAZON COM INC | COM | 023135106 | 8,849,887 | 85,680 | SH | DFND | 85,680 | 0 | 0 | ||
AMGEN INC | COM | 031162100 | 2,417,500 | 10,000 | SH | DFND | 1,2 | 10,000 | 0 | 0 | |
ANNEXON INC | COM | 03589W102 | 962,500 | 250,000 | SH | DFND | 1,2 | 250,000 | 0 | 0 | |
ARBE ROBOTICS LTD | ORDINARY SHARES | M1R95N100 | 137,696 | 43,165 | SH | DFND | 43,165 | 0 | 0 | ||
ARCELLX INC | COMMON STOCK | 03940C100 | 5,160,305 | 167,488 | SH | DFND | 1,2 | 167,488 | 0 | 0 | |
ASTRAZENECA PLC | SPONSORED ADR | 046353108 | 19,786,015 | 285,060 | SH | DFND | 1,2 | 285,060 | 0 | 0 | |
ASTRIA THERAPEUTICS INC | COM | 04635X102 | 5,599,539 | 421,018 | SH | DFND | 1,2 | 421,018 | 0 | 0 | |
BELLUS HEALTH INC NEW | COM NEW | 07987C204 | 5,758,992 | 799,860 | SH | DFND | 1,2 | 799,860 | 0 | 0 | |
BIOGEN INC | COM | 09062X103 | 9,318,453 | 33,516 | SH | DFND | 1,2 | 33,516 | 0 | 0 | |
BRIDGEBIO PHARMA INC | COM | 10806X102 | 9,317,678 | 561,983 | SH | DFND | 1,2 | 561,983 | 0 | 0 | |
BRIDGEBIO PHARMA INC | COM | 10806X102 | 3,316,000 | 200,000 | SH | Call | DFND | 1,2 | 0 | 0 | 0 |
CAMTEK LTD | ORD | M20791105 | 6,789,655 | 239,494 | SH | DFND | 239,494 | 0 | 0 | ||
CHINOOK THERAPEUTICS INC | COM | 16961L106 | 2,134,430 | 92,200 | SH | DFND | 1,2 | 92,200 | 0 | 0 | |
COGENT BIOSCIENCES INC | COM | 19240Q201 | 3,237,000 | 300,000 | SH | DFND | 1,2 | 300,000 | 0 | 0 | |
CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 1,328,917 | 82,747 | SH | DFND | 1,2 | 82,747 | 0 | 0 | |
CYCLACEL PHARMACEUTICALS INC | COM | 23254L603 | 142,625 | 250,000 | SH | DFND | 1,2 | 250,000 | 0 | 0 | |
DISC MEDICINE INC | COM | 254604101 | 4,662,075 | 220,013 | SH | DFND | 1,2 | 220,013 | 0 | 0 | |
DYNE THERAPEUTICS INC | COM | 26818M108 | 2,526,520 | 219,316 | SH | DFND | 1,2 | 219,316 | 0 | 0 | |
ENLIGHT RENEWABLE ENERGY LTD | SHS | M4056D110 | 7,628,619 | 450,864 | SH | DFND | 450,864 | 0 | 0 | ||
ENPHASE ENERGY INC | NOTE 3/0 | 29355AAK3 | 11,190,251 | 10,725,000 | SH | DFND | 10,725,000 | 0 | 0 | ||
FIVERR INTL LTD | NOTE 11/0 | 33835LAA3 | 208,223 | 250,000 | SH | DFND | 250,000 | 0 | 0 | ||
FUSION PHARMACEUTICALS INC | COM | 36118A100 | 4,838,934 | 1,283,537 | SH | DFND | 1,2 | 1,283,537 | 0 | 0 | |
GRACELL BIOTECHNOLOGIES INC | SPONSORED ADS | 38406L103 | 4,390,679 | 2,360,580 | SH | DFND | 1,2 | 2,360,580 | 0 | 0 | |
IMMATICS N.V | *W EXP 07/01/202 | N44445117 | 144,000 | 100,000 | SH | DFND | 1,2 | 100,000 | 0 | 0 | |
IMMATICS N.V | SHS | N44445109 | 5,387,879 | 780,852 | SH | DFND | 1,2 | 780,852 | 0 | 0 | |
INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 236,160 | 1,476,000 | SH | DFND | 1,2 | 1,476,000 | 0 | 0 | |
INOZYME PHARMA INC | COM | 45790W108 | 10,210,046 | 1,781,858 | SH | DFND | 1,2 | 1,781,858 | 0 | 0 | |
INVESCO QQQ TR | UNIT SER 1 | 46090E103 | 8,457,468 | 26,353 | SH | DFND | 26,353 | 0 | 0 | ||
ISHARES TR | RUSSELL 2000 ETF | 464287655 | 75,088,557 | 420,900 | SH | Put | DFND | 1,2 | 420,900 | 0 | 0 |
IVERIC BIO INC | COM | 46583P102 | 5,634,609 | 231,591 | SH | DFND | 1,2 | 231,591 | 0 | 0 | |
JASPER THERAPEUTICS INC | COM | 471871103 | 7,319,654 | 4,044,008 | SH | DFND | 1,2 | 4,044,008 | 0 | 0 | |
JOHNSON & JOHNSON | COM | 478160104 | 18,573,805 | 119,831 | SH | DFND | 1,2 | 119,831 | 0 | 0 | |
KEROS THERAPEUTICS INC | COM | 492327101 | 1,286,081 | 30,119 | SH | DFND | 1,2 | 30,119 | 0 | 0 | |
KEZAR LIFE SCIENCES INC | COM | 49372L100 | 5,910,154 | 1,888,228 | SH | DFND | 1,2 | 1,888,228 | 0 | 0 | |
KINIKSA PHARMACEUTICALS LTD | COM CL A | G5269C101 | 4,845,045 | 450,283 | SH | DFND | 1,2 | 450,283 | 0 | 0 | |
KURA ONCOLOGY INC | COM | 50127T109 | 7,378,200 | 603,287 | SH | DFND | 1,2 | 603,287 | 0 | 0 | |
LILLY ELI & CO | COM | 532457108 | 10,882,980 | 31,690 | SH | DFND | 1,2 | 31,690 | 0 | 0 | |
MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 4,602,940 | 19,000 | SH | DFND | 1,2 | 19,000 | 0 | 0 | |
MEDIWOUND LTD | SHS NEW | M68830112 | 1,480,212 | 111,127 | SH | DFND | 1,2 | 111,127 | 0 | 0 | |
MERCK & CO INC | COM | 58933Y105 | 12,830,634 | 120,600 | SH | DFND | 1,2 | 120,600 | 0 | 0 | |
MERSANA THERAPEUTICS INC | COM | 59045L106 | 43,652 | 10,621 | SH | DFND | 1,2 | 10,621 | 0 | 0 | |
MERUS N V | COM | N5749R100 | 6,200,671 | 336,993 | SH | DFND | 1,2 | 336,993 | 0 | 0 | |
MICROSOFT CORP | COM | 594918104 | 15,747,811 | 54,623 | SH | DFND | 54,623 | 0 | 0 | ||
MINERALYS THERAPEUTICS INC | COM | 603170101 | 5,308,740 | 339,000 | SH | DFND | 1,2 | 339,000 | 0 | 0 | |
MIRUM PHARMACEUTICALS INC | COM | 604749101 | 2,626,251 | 109,336 | SH | DFND | 1,2 | 109,336 | 0 | 0 | |
NICE LTD | SPONSORED ADR | 653656108 | 26,432,675 | 115,482 | SH | DFND | 115,482 | 0 | 0 | ||
NOVARTIS AG | SPONSORED ADR | 66987V109 | 5,520,000 | 60,000 | SH | DFND | 1,2 | 60,000 | 0 | 0 | |
NOVO-NORDISK A S | ADR | 670100205 | 11,384,876 | 71,540 | SH | DFND | 1,2 | 71,540 | 0 | 0 | |
NUTRIEN LTD | COM | 67077M108 | 10,742,664 | 145,466 | SH | DFND | 145,466 | 0 | 0 | ||
ONCORUS INC | COM | 68236R103 | 185,903 | 540,258 | SH | DFND | 1,2 | 540,258 | 0 | 0 | |
OTONOMO TECHNOLOGIES LTD | ORDINARY SHARES | M7571L103 | 186,409 | 391,863 | SH | DFND | 391,863 | 0 | 0 | ||
PALO ALTO NETWORKS INC | COM | 697435105 | 3,994,800 | 20,000 | SH | DFND | 20,000 | 0 | 0 | ||
PERION NETWORK LTD | SHS NEW | M78673114 | 5,145,400 | 130,000 | SH | DFND | 130,000 | 0 | 0 | ||
PFIZER INC | COM | 717081103 | 5,712,000 | 140,000 | SH | DFND | 1,2 | 140,000 | 0 | 0 | |
PMV PHARMACEUTICALS INC | COM | 69353Y103 | 895,806 | 187,800 | SH | DFND | 1,2 | 187,800 | 0 | 0 | |
POINT BIOPHARMA GLOBAL INC | COM | 730541109 | 6,925,707 | 952,642 | SH | DFND | 1,2 | 952,642 | 0 | 0 | |
PTC THERAPEUTICS INC | COM | 69366J200 | 7,706,804 | 159,100 | SH | DFND | 1,2 | 159,100 | 0 | 0 | |
REATA PHARMACEUTICALS INC | CL A | 75615P103 | 699,084 | 7,689 | SH | DFND | 1,2 | 7,689 | 0 | 0 | |
REZOLUTE INC | COM NEW | 76200L309 | 2,219,322 | 1,155,897 | SH | DFND | 1,2 | 1,155,897 | 0 | 0 | |
RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 2,480,075 | 1,878,845 | SH | DFND | 1,2 | 1,878,845 | 0 | 0 | |
ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 4,042,680 | 236,000 | SH | DFND | 1,2 | 236,000 | 0 | 0 | |
SAGE THERAPEUTICS INC | COM | 78667J108 | 6,503,800 | 155,000 | SH | DFND | 1,2 | 155,000 | 0 | 0 | |
SANOFI | SPONSORED ADR | 80105N105 | 28,816,206 | 529,515 | SH | DFND | 1,2 | 529,515 | 0 | 0 | |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 6,064,520 | 44,000 | SH | DFND | 1,2 | 44,000 | 0 | 0 | |
SELECT SECTOR SPDR TR | SBI INT-INDS | 81369Y704 | 5,838,086 | 57,700 | SH | Put | DFND | 57,700 | 0 | 0 | |
SELECTA BIOSCIENCES INC | COM | 816212104 | 3,231,750 | 2,325,000 | SH | DFND | 1,2 | 2,325,000 | 0 | 0 | |
SPDR S&P 500 ETF TR | TR UNIT | 78462F103 | 30,704,251 | 75,000 | SH | Put | DFND | 1,2 | 75,000 | 0 | 0 |
SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 8,175,668 | 317,625 | SH | DFND | 1,2 | 317,625 | 0 | 0 | |
SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 14,426,248 | 683,061 | SH | DFND | 1,2 | 683,061 | 0 | 0 | |
TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | 18,049,575 | 2,039,500 | SH | DFND | 1,2 | 2,039,500 | 0 | 0 | |
TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | 18,027,451 | 2,037,000 | SH | Call | DFND | 0 | 0 | 0 | |
TRAVERE THERAPEUTICS INC | COM | 89422G107 | 4,216,875 | 187,500 | SH | DFND | 1,2 | 187,500 | 0 | 0 | |
ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 7,366,210 | 183,696 | SH | DFND | 1,2 | 183,696 | 0 | 0 | |
UNIQURE NV | SHS | N90064101 | 1,248,680 | 62,000 | SH | DFND | 1,2 | 62,000 | 0 | 0 | |
UNIQURE NV | SHS | N90064101 | 3,532,556 | 175,400 | SH | Call | DFND | 1,2 | 0 | 0 | 0 |
VAXCYTE INC | COM | 92243G108 | 3,373,200 | 90,000 | SH | DFND | 1,2 | 90,000 | 0 | 0 | |
WEREWOLF THERAPEUTICS INC | COM | 95075A107 | 1,629,706 | 626,810 | SH | DFND | 1,2 | 626,810 | 0 | 0 |