The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
|
COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
111 INC | ADS | 68247Q102 | 1,173 | 85,000 | SH | DFND | 2 | 85,000 | 0 | 0 | |
1LIFE HEALTHCARE INC | COM | 68269G107 | 32,168 | 823,135 | SH | DFND | 2 | 823,135 | 0 | 0 | |
10X GENOMICS INC | CL A COM | 88025U109 | 41,456 | 229,039 | SH | DFND | 2 | 229,039 | 0 | 0 | |
ABBOTT LABS | COM | 002824100 | 166,937 | 1,392,999 | SH | DFND | 2 | 1,392,999 | 0 | 0 | |
ABBVIE INC | COM | 00287Y109 | 41,567 | 384,100 | SH | DFND | 2 | 384,100 | 0 | 0 | |
ABIOMED INC | COM | 003654100 | 45,478 | 142,684 | SH | DFND | 2 | 142,684 | 0 | 0 | |
ACADIA PHARMACEUTICALS INC | COM | 004225108 | 1,700 | 65,900 | SH | DFND | 2 | 65,900 | 0 | 0 | |
ACCOLADE INC | COM | 00437E102 | 29,509 | 650,401 | SH | DFND | 2 | 650,401 | 0 | 0 | |
ACCOLADE INC | COM | 00437E102 | 41,319 | 910,720 | SH | DFND | 3 | 910,720 | 0 | 0 | |
AGILENT TECHNOLOGIES INC | COM | 00846U101 | 343 | 2,700 | SH | DFND | 2 | 2,700 | 0 | 0 | |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 2,174 | 42,100 | SH | DFND | 2 | 42,100 | 0 | 0 | |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 232,121 | 4,494,992 | SH | DFND | 1,2 | 4,494,992 | 0 | 0 | |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 2,187 | 14,300 | SH | DFND | 2 | 14,300 | 0 | 0 | |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 197,931 | 1,294,428 | SH | DFND | 1,2 | 1,294,428 | 0 | 0 | |
ALIGN TECHNOLOGY INC | COM | 016255101 | 77,959 | 143,960 | SH | DFND | 2 | 143,960 | 0 | 0 | |
ALLAKOS INC | COM | 01671P100 | 2,123 | 18,500 | SH | DFND | 2 | 18,500 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 9,248 | 65,500 | SH | DFND | 2 | 65,500 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 159,545 | 1,130,000 | SH | DFND | 1,2 | 1,130,000 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 60,940 | 431,614 | SH | DFND | 3 | 431,614 | 0 | 0 | |
AMEDISYS INC | COM | 023436108 | 16,016 | 60,487 | SH | DFND | 2 | 60,487 | 0 | 0 | |
AMERICAN EXPRESS CO | COM | 025816109 | 368 | 2,600 | SH | DFND | 2 | 2,600 | 0 | 0 | |
AMERICAN WELL CORP | CL A | 03044L105 | 32,455 | 1,868,433 | SH | DFND | 2 | 1,868,433 | 0 | 0 | |
AMGEN INC | COM | 031162100 | 12,154 | 48,850 | SH | DFND | 2 | 48,850 | 0 | 0 | |
AMGEN INC | COM | 031162100 | 31,746 | 127,590 | SH | DFND | 3 | 127,590 | 0 | 0 | |
ANSYS INC | COM | 03662Q105 | 306 | 900 | SH | DFND | 2 | 900 | 0 | 0 | |
ANTHEM INC | COM | 036752103 | 63,825 | 177,809 | SH | DFND | 2 | 177,809 | 0 | 0 | |
ANTHEM INC | COM | 036752103 | 74,568 | 207,739 | SH | DFND | 3 | 207,739 | 0 | 0 | |
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 2,060 | 48,000 | SH | DFND | 2 | 48,000 | 0 | 0 | |
ARCUS BIOSCIENCES INC | COM | 03969F109 | 2,106 | 75,000 | SH | DFND | 2 | 75,000 | 0 | 0 | |
ARGENX SE | SPONSORED ADR | 04016X101 | 6,614 | 24,016 | SH | DFND | 2 | 24,016 | 0 | 0 | |
ARGENX SE | SPONSORED ADR | 04016X101 | 256,261 | 930,538 | SH | DFND | 1,2 | 930,538 | 0 | 0 | |
ARVINAS INC | COM | 04335A105 | 965 | 14,600 | SH | DFND | 2 | 14,600 | 0 | 0 | |
ARVINAS INC | COM | 04335A105 | 135,961 | 2,056,903 | SH | DFND | 1,2 | 2,056,903 | 0 | 0 | |
ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 1,998 | 15,500 | SH | DFND | 2 | 15,500 | 0 | 0 | |
ASPEN TECHNOLOGY INC | COM | 045327103 | 346 | 2,400 | SH | DFND | 2 | 2,400 | 0 | 0 | |
ATRICURE INC | COM | 04963C209 | 32,610 | 497,712 | SH | DFND | 3 | 497,712 | 0 | 0 | |
AVANTOR INC | COM | 05352A100 | 14,818 | 512,216 | SH | DFND | 2 | 512,216 | 0 | 0 | |
AXONICS MODULATION TECHNOLOG | COM | 05465P101 | 50,849 | 849,034 | SH | DFND | 2 | 849,034 | 0 | 0 | |
AXONICS MODULATION TECHNOLOG | COM | 05465P101 | 36,368 | 607,240 | SH | DFND | 3 | 607,240 | 0 | 0 | |
BAXTER INTL INC | COM | 071813109 | 40,030 | 474,623 | SH | DFND | 2 | 474,623 | 0 | 0 | |
BEAM THERAPEUTICS INC | COM | 07373V105 | 45,368 | 566,821 | SH | DFND | 1,2 | 566,821 | 0 | 0 | |
BECTON DICKINSON & CO | COM | 075887109 | 112,084 | 460,965 | SH | DFND | 2 | 460,965 | 0 | 0 | |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 20,780 | 59,700 | SH | DFND | 2 | 59,700 | 0 | 0 | |
BERKELEY LTS INC | COM | 084310101 | 19,037 | 379,003 | SH | DFND | 2 | 379,003 | 0 | 0 | |
BIOGEN INC | COM | 09062X103 | 5,987 | 21,400 | SH | DFND | 2 | 21,400 | 0 | 0 | |
BIOGEN INC | COM | 09062X103 | 150,226 | 537,000 | SH | DFND | 1,2 | 537,000 | 0 | 0 | |
BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 2,461 | 36,000 | SH | DFND | 2 | 36,000 | 0 | 0 | |
BIONTECH SE | SPONSORED ADS | 09075V102 | 4,968 | 45,500 | SH | DFND | 2 | 45,500 | 0 | 0 | |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 2,794 | 37,000 | SH | DFND | 2 | 37,000 | 0 | 0 | |
BIO RAD LABS INC | CL A | 090572207 | 57,232 | 100,202 | SH | DFND | 3 | 100,202 | 0 | 0 | |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 315 | 13,000 | SH | DFND | 2 | 13,000 | 0 | 0 | |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 54,100 | 2,230,000 | SH | DFND | 1,2 | 2,230,000 | 0 | 0 | |
BOOKING HOLDINGS INC | COM | 09857L108 | 373 | 160 | SH | DFND | 2 | 160 | 0 | 0 | |
BOSTON SCIENTIFIC CORP | COM | 101137107 | 89,930 | 2,326,787 | SH | DFND | 2 | 2,326,787 | 0 | 0 | |
BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 38,364 | 607,700 | SH | DFND | 2 | 607,700 | 0 | 0 | |
BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 93,272 | 1,477,452 | SH | DFND | 3 | 1,477,452 | 0 | 0 | |
BROWN FORMAN CORP | CL B | 115637209 | 317 | 4,600 | SH | DFND | 2 | 4,600 | 0 | 0 | |
BURNING ROCK BIOTECH LTD | SPONSORED ADR | 12233L107 | 11,654 | 432,926 | SH | DFND | 2 | 432,926 | 0 | 0 | |
CARDINAL HEALTH INC | COM | 14149Y108 | 1,458 | 24,000 | SH | DFND | 2 | 24,000 | 0 | 0 | |
CAREDX INC | COM | 14167L103 | 12,962 | 190,371 | SH | DFND | 3 | 190,371 | 0 | 0 | |
CARMAX INC | COM | 143130102 | 378 | 2,850 | SH | DFND | 2 | 2,850 | 0 | 0 | |
CATALENT INC | COM | 148806102 | 284 | 2,700 | SH | DFND | 2 | 2,700 | 0 | 0 | |
CELLECTIS S A | SPON ADS | 15117K103 | 1,688 | 83,500 | SH | DFND | 2 | 83,500 | 0 | 0 | |
CENTENE CORP DEL | COM | 15135B101 | 82,482 | 1,290,597 | SH | DFND | 2 | 1,290,597 | 0 | 0 | |
CHARLES RIV LABS INTL INC | COM | 159864107 | 54,600 | 188,385 | SH | DFND | 3 | 188,385 | 0 | 0 | |
CIGNA CORP NEW | COM | 125523100 | 108,339 | 448,162 | SH | DFND | 2 | 448,162 | 0 | 0 | |
CLOROX CO DEL | COM | 189054109 | 386 | 2,000 | SH | DFND | 2 | 2,000 | 0 | 0 | |
CONSTELLATION BRANDS INC | CL A | 21036P108 | 333 | 1,459 | SH | DFND | 2 | 1,459 | 0 | 0 | |
COOPER COS INC | COM NEW | 216648402 | 26,643 | 69,367 | SH | DFND | 2 | 69,367 | 0 | 0 | |
COSTAR GROUP INC | COM | 22160N109 | 288 | 350 | SH | DFND | 2 | 350 | 0 | 0 | |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 1,072 | 8,800 | SH | DFND | 2 | 8,800 | 0 | 0 | |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 118,144 | 969,584 | SH | DFND | 1,2 | 969,584 | 0 | 0 | |
CUREVAC NV | COM | N2451R105 | 2,643 | 28,900 | SH | DFND | 2 | 28,900 | 0 | 0 | |
CVS HEALTH CORP | COM | 126650100 | 9,370 | 124,548 | SH | DFND | 2 | 124,548 | 0 | 0 | |
CYBERARK SOFTWARE LTD | SHS | M2682V108 | 272 | 2,100 | SH | DFND | 2 | 2,100 | 0 | 0 | |
DANAHER CORPORATION | COM | 235851102 | 106,494 | 473,140 | SH | DFND | 2 | 473,140 | 0 | 0 | |
DAVITA INC | COM | 23918K108 | 39,616 | 367,600 | SH | DFND | 2 | 367,600 | 0 | 0 | |
DENTSPLY SIRONA INC | COM | 24906P109 | 10,154 | 159,129 | SH | DFND | 2 | 159,129 | 0 | 0 | |
DEXCOM INC | COM | 252131107 | 77,698 | 216,193 | SH | DFND | 2 | 216,193 | 0 | 0 | |
DICERNA PHARMACEUTICALS INC | COM | 253031108 | 1,739 | 68,000 | SH | DFND | 2 | 68,000 | 0 | 0 | |
DOLBY LABORATORIES INC | COM CL A | 25659T107 | 355 | 3,600 | SH | DFND | 2 | 3,600 | 0 | 0 | |
DOMINOS PIZZA INC | COM | 25754A201 | 368 | 1,000 | SH | DFND | 2 | 1,000 | 0 | 0 | |
DR REDDYS LABS LTD | ADR | 256135203 | 522 | 8,500 | SH | DFND | 2 | 8,500 | 0 | 0 | |
EARGO INC | COM | 270087109 | 19,373 | 387,857 | SH | DFND | 2 | 387,857 | 0 | 0 | |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 74,461 | 890,256 | SH | DFND | 2 | 890,256 | 0 | 0 | |
ELECTRONIC ARTS INC | COM | 285512109 | 307 | 2,270 | SH | DFND | 2 | 2,270 | 0 | 0 | |
ENTEGRIS INC | COM | 29362U104 | 335 | 3,000 | SH | DFND | 2 | 3,000 | 0 | 0 | |
ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 1,156 | 41,200 | SH | DFND | 2 | 41,200 | 0 | 0 | |
ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 110,740 | 3,947,964 | SH | DFND | 1,2 | 3,947,964 | 0 | 0 | |
ESSA PHARMA INC | COM NEW | 29668H708 | 53,040 | 1,825,814 | SH | DFND | 1,2 | 1,825,814 | 0 | 0 | |
EVOLENT HEALTH INC | CL A | 30050B101 | 32,884 | 1,627,942 | SH | DFND | 2 | 1,627,942 | 0 | 0 | |
EVOLENT HEALTH INC | CL A | 30050B101 | 38,392 | 1,900,605 | SH | DFND | 3 | 1,900,605 | 0 | 0 | |
EXACT SCIENCES CORP | COM | 30063P105 | 28,746 | 218,140 | SH | DFND | 3 | 218,140 | 0 | 0 | |
EXELIXIS INC | COM | 30161Q104 | 2,474 | 109,500 | SH | DFND | 2 | 109,500 | 0 | 0 | |
EXELIXIS INC | COM | 30161Q104 | 64,043 | 2,835,000 | SH | DFND | 1,2 | 2,835,000 | 0 | 0 | |
FACTSET RESH SYS INC | COM | 303075105 | 324 | 1,050 | SH | DFND | 2 | 1,050 | 0 | 0 | |
FASTENAL CO | COM | 311900104 | 352 | 7,000 | SH | DFND | 2 | 7,000 | 0 | 0 | |
FATE THERAPEUTICS INC | COM | 31189P102 | 3,958 | 48,000 | SH | DFND | 2 | 48,000 | 0 | 0 | |
FATE THERAPEUTICS INC | COM | 31189P102 | 178,202 | 2,161,336 | SH | DFND | 1,2 | 2,161,336 | 0 | 0 | |
FIBROGEN INC | COM | 31572Q808 | 2,083 | 60,000 | SH | DFND | 2 | 60,000 | 0 | 0 | |
FORTINET INC | COM | 34959E109 | 406 | 2,200 | SH | DFND | 2 | 2,200 | 0 | 0 | |
GARTNER INC | COM | 366651107 | 383 | 2,100 | SH | DFND | 2 | 2,100 | 0 | 0 | |
GENERATION BIO CO | COM | 37148K100 | 68,110 | 2,393,180 | SH | DFND | 1,2 | 2,393,180 | 0 | 0 | |
GENETRON HLDGS LTD | ADS | 37186H100 | 13,565 | 632,087 | SH | DFND | 2 | 632,087 | 0 | 0 | |
GILEAD SCIENCES INC | COM | 375558103 | 7,174 | 111,000 | SH | DFND | 2 | 111,000 | 0 | 0 | |
GLAUKOS CORP | COM | 377322102 | 41,070 | 489,342 | SH | DFND | 2 | 489,342 | 0 | 0 | |
GLOBUS MED INC | CL A | 379577208 | 39,932 | 647,509 | SH | DFND | 2 | 647,509 | 0 | 0 | |
GRACO INC | COM | 384109104 | 322 | 4,500 | SH | DFND | 2 | 4,500 | 0 | 0 | |
GUARDANT HEALTH INC | COM | 40131M109 | 46,232 | 302,866 | SH | DFND | 2 | 302,866 | 0 | 0 | |
GW PHARMACEUTICALS PLC | ADS | 36197T103 | 2,169 | 10,000 | SH | DFND | 2 | 10,000 | 0 | 0 | |
HALOZYME THERAPEUTICS INC | COM | 40637H109 | 3,127 | 75,000 | SH | DFND | 2 | 75,000 | 0 | 0 | |
HALOZYME THERAPEUTICS INC | COM | 40637H109 | 122,442 | 2,936,966 | SH | DFND | 1,2 | 2,936,966 | 0 | 0 | |
HCA HEALTHCARE INC | COM | 40412C101 | 70,545 | 374,563 | SH | DFND | 2 | 374,563 | 0 | 0 | |
HEALTH CATALYST INC | COM | 42225T107 | 34,697 | 741,855 | SH | DFND | 2 | 741,855 | 0 | 0 | |
HILL ROM HLDGS INC | COM | 431475102 | 72,986 | 660,628 | SH | DFND | 3 | 660,628 | 0 | 0 | |
HOLOGIC INC | COM | 436440101 | 28,992 | 389,779 | SH | DFND | 2 | 389,779 | 0 | 0 | |
HOLOGIC INC | COM | 436440101 | 38,973 | 523,973 | SH | DFND | 3 | 523,973 | 0 | 0 | |
HOMOLOGY MEDICINES INC | COM | 438083107 | 16,346 | 1,737,122 | SH | DFND | 1,2 | 1,737,122 | 0 | 0 | |
HORIZON THERAPEUTICS PUB L | SHS | G46188101 | 37,598 | 408,500 | SH | DFND | 2 | 408,500 | 0 | 0 | |
HUMANA INC | COM | 444859102 | 60,682 | 144,739 | SH | DFND | 2 | 144,739 | 0 | 0 | |
HUMANA INC | COM | 444859102 | 60,364 | 143,980 | SH | DFND | 3 | 143,980 | 0 | 0 | |
HUTCHISON CHINA MEDITECH LTD | SPONSORED ADR | 44842L103 | 27,558 | 975,488 | SH | DFND | 3 | 975,488 | 0 | 0 | |
IDEXX LABS INC | COM | 45168D104 | 44,649 | 91,249 | SH | DFND | 2 | 91,249 | 0 | 0 | |
ILLUMINA INC | COM | 452327109 | 23,396 | 60,918 | SH | DFND | 2 | 60,918 | 0 | 0 | |
I MAB | SPONSORED ADS | 44975P103 | 9,619 | 198,457 | SH | DFND | 2 | 198,457 | 0 | 0 | |
INCYTE CORP | COM | 45337C102 | 8,834 | 108,700 | SH | DFND | 2 | 108,700 | 0 | 0 | |
INCYTE CORP | COM | 45337C102 | 235,439 | 2,897,000 | SH | DFND | 1,2 | 2,897,000 | 0 | 0 | |
INOGEN INC | COM | 45780L104 | 14,751 | 280,863 | SH | DFND | 2 | 280,863 | 0 | 0 | |
INSMED INC | COM PAR $.01 | 457669307 | 84,372 | 2,477,166 | SH | DFND | 3 | 2,477,166 | 0 | 0 | |
INSPIRE MED SYS INC | COM | 457730109 | 66,276 | 320,188 | SH | DFND | 2 | 320,188 | 0 | 0 | |
INSULET CORP | COM | 45784P101 | 113,288 | 434,188 | SH | DFND | 2 | 434,188 | 0 | 0 | |
INTERCEPT PHARMACEUTICALS IN | COM | 45845P108 | 185 | 8,000 | SH | DFND | 2 | 8,000 | 0 | 0 | |
INTERCONTINENTAL EXCHANGE IN | COM | 45866F104 | 335 | 3,000 | SH | DFND | 2 | 3,000 | 0 | 0 | |
INTERSECT ENT INC | COM | 46071F103 | 12,903 | 617,968 | SH | DFND | 2 | 617,968 | 0 | 0 | |
INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 4,122 | 121,500 | SH | DFND | 2 | 121,500 | 0 | 0 | |
INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 120,059 | 3,538,419 | SH | DFND | 1,2 | 3,538,419 | 0 | 0 | |
INTUIT | COM | 461202103 | 345 | 900 | SH | DFND | 2 | 900 | 0 | 0 | |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 163,139 | 220,775 | SH | DFND | 2 | 220,775 | 0 | 0 | |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 8,410 | 187,050 | SH | DFND | 2 | 187,050 | 0 | 0 | |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 367,187 | 8,166,962 | SH | DFND | 1,2 | 8,166,962 | 0 | 0 | |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 28,335 | 630,222 | SH | DFND | 3 | 630,222 | 0 | 0 | |
IPG PHOTONICS CORP | COM | 44980X109 | 285 | 1,350 | SH | DFND | 2 | 1,350 | 0 | 0 | |
IQVIA HLDGS INC | COM | 46266C105 | 348 | 1,800 | SH | DFND | 2 | 1,800 | 0 | 0 | |
IRHYTHM TECHNOLOGIES INC | COM | 450056106 | 12,168 | 87,631 | SH | DFND | 2 | 87,631 | 0 | 0 | |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 7,775 | 47,300 | SH | DFND | 2 | 47,300 | 0 | 0 | |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 82,736 | 503,350 | SH | DFND | 3 | 503,350 | 0 | 0 | |
JD.COM INC | SPON ADR CL A | 47215P106 | 304 | 3,600 | SH | DFND | 2 | 3,600 | 0 | 0 | |
JOHNSON & JOHNSON | COM | 478160104 | 6,755 | 41,100 | SH | DFND | 2 | 41,100 | 0 | 0 | |
JUMIA TECHNOLOGIES AG | SPONSORED ADS | 48138M105 | 638 | 18,000 | SH | DFND | 2 | 18,000 | 0 | 0 | |
KEZAR LIFE SCIENCES INC | COM | 49372L100 | 27,018 | 4,533,148 | SH | DFND | 1,2 | 4,533,148 | 0 | 0 | |
KOSMOS ENERGY LTD | COM | 500688106 | 599 | 195,000 | SH | DFND | 2 | 195,000 | 0 | 0 | |
KURA ONCOLOGY INC | COM | 50127T109 | 1,640 | 58,000 | SH | DFND | 2 | 58,000 | 0 | 0 | |
LABORATORY CORP AMER HLDGS | COM NEW | 50540R409 | 3,621 | 14,200 | SH | DFND | 2 | 14,200 | 0 | 0 | |
LAUDER ESTEE COS INC | CL A | 518439104 | 392 | 1,348 | SH | DFND | 2 | 1,348 | 0 | 0 | |
LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 | 17,506 | 603,243 | SH | DFND | 2 | 603,243 | 0 | 0 | |
LIVE NATION ENTERTAINMENT IN | COM | 538034109 | 398 | 4,700 | SH | DFND | 2 | 4,700 | 0 | 0 | |
MACROGENICS INC | COM | 556099109 | 1,591 | 49,950 | SH | DFND | 2 | 49,950 | 0 | 0 | |
MACROGENICS INC | COM | 556099109 | 161,497 | 5,070,564 | SH | DFND | 1,2 | 5,070,564 | 0 | 0 | |
MACROGENICS INC | COM | 556099109 | 28,901 | 907,412 | SH | DFND | 3 | 907,412 | 0 | 0 | |
MARKEL CORP | COM | 570535104 | 456 | 400 | SH | DFND | 2 | 400 | 0 | 0 | |
MARKETAXESS HLDGS INC | COM | 57060D108 | 330 | 662 | SH | DFND | 2 | 662 | 0 | 0 | |
MASIMO CORP | COM | 574795100 | 28,982 | 126,196 | SH | DFND | 2 | 126,196 | 0 | 0 | |
MATCH GROUP INC NEW | COM | 57667L107 | 327 | 2,378 | SH | DFND | 2 | 2,378 | 0 | 0 | |
MCCORMICK & CO INC | COM NON VTG | 579780206 | 526 | 5,900 | SH | DFND | 2 | 5,900 | 0 | 0 | |
MCKESSON CORP | COM | 58155Q103 | 474 | 2,430 | SH | DFND | 2 | 2,430 | 0 | 0 | |
MEDTRONIC PLC | SHS | G5960L103 | 39,281 | 332,522 | SH | DFND | 2 | 332,522 | 0 | 0 | |
MERCADOLIBRE INC | COM | 58733R102 | 250 | 170 | SH | DFND | 2 | 170 | 0 | 0 | |
MERSANA THERAPEUTICS INC | COM | 59045L106 | 1,456 | 90,010 | SH | DFND | 2 | 90,010 | 0 | 0 | |
MERSANA THERAPEUTICS INC | COM | 59045L106 | 44,657 | 2,760,000 | SH | DFND | 1,2 | 2,760,000 | 0 | 0 | |
METTLER TOLEDO INTERNATIONAL | COM | 592688105 | 312 | 270 | SH | DFND | 2 | 270 | 0 | 0 | |
MIRATI THERAPEUTICS INC | COM | 60468T105 | 1,679 | 9,800 | SH | DFND | 2 | 9,800 | 0 | 0 | |
MODERNA INC | COM | 60770K107 | 14,398 | 109,950 | SH | DFND | 2 | 109,950 | 0 | 0 | |
MODERNA INC | COM | 60770K107 | 353,565 | 2,700,000 | SH | DFND | 1,2 | 2,700,000 | 0 | 0 | |
MOLECULAR TEMPLATES INC | COM | 608550109 | 404 | 32,000 | SH | DFND | 2 | 32,000 | 0 | 0 | |
MOLECULAR TEMPLATES INC | COM | 608550109 | 102,425 | 8,116,105 | SH | DFND | 1,2 | 8,116,105 | 0 | 0 | |
MOLINA HEALTHCARE INC | COM | 60855R100 | 47,976 | 205,234 | SH | DFND | 2 | 205,234 | 0 | 0 | |
MOODYS CORP | COM | 615369105 | 373 | 1,250 | SH | DFND | 2 | 1,250 | 0 | 0 | |
MSCI INC | COM | 55354G100 | 342 | 816 | SH | DFND | 2 | 816 | 0 | 0 | |
MYOVANT SCIENCES LTD | COM | G637AM102 | 967 | 47,000 | SH | DFND | 2 | 47,000 | 0 | 0 | |
MYOVANT SCIENCES LTD | COM | G637AM102 | 105,926 | 5,147,039 | SH | DFND | 1,2 | 5,147,039 | 0 | 0 | |
NEKTAR THERAPEUTICS | COM | 640268108 | 576 | 28,800 | SH | DFND | 2 | 28,800 | 0 | 0 | |
NEKTAR THERAPEUTICS | COM | 640268108 | 52,414 | 2,620,676 | SH | DFND | 1,2 | 2,620,676 | 0 | 0 | |
NEKTAR THERAPEUTICS | COM | 640268108 | 26,103 | 1,305,128 | SH | DFND | 3 | 1,305,128 | 0 | 0 | |
NEOGENOMICS INC | COM NEW | 64049M209 | 38,003 | 787,953 | SH | DFND | 3 | 787,953 | 0 | 0 | |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 34,927 | 359,151 | SH | DFND | 2 | 359,151 | 0 | 0 | |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 283,523 | 2,915,400 | SH | DFND | 1,2 | 2,915,400 | 0 | 0 | |
NEVRO CORP | COM | 64157F103 | 25,251 | 181,013 | SH | DFND | 2 | 181,013 | 0 | 0 | |
NUANCE COMMUNICATIONS INC | COM | 67020Y100 | 20,462 | 468,885 | SH | DFND | 2 | 468,885 | 0 | 0 | |
OLINK HLDG AB | SPONSORED ADS | 680710100 | 5,477 | 152,137 | SH | DFND | 2 | 152,137 | 0 | 0 | |
OMNICELL INC | COM | 68213N109 | 42,587 | 327,919 | SH | DFND | 2 | 327,919 | 0 | 0 | |
OPTHEA LTD | SPONSORED ADS | 68386J208 | 483 | 50,000 | SH | DFND | 2 | 50,000 | 0 | 0 | |
OPTION CARE HEALTH INC | COM NEW | 68404L201 | 26,758 | 1,508,320 | SH | DFND | 3 | 1,508,320 | 0 | 0 | |
OSCAR HEALTH INC | CL A | 687793109 | 12,219 | 454,574 | SH | DFND | 2 | 454,574 | 0 | 0 | |
OUTSET MED INC | COM | 690145107 | 13,908 | 255,714 | SH | DFND | 2 | 255,714 | 0 | 0 | |
PACIFIC BIOSIENCES CALIF IN | COM | 69404D108 | 53,879 | 1,617,505 | SH | DFND | 2 | 1,617,505 | 0 | 0 | |
PAYCHEX INC | COM | 704326107 | 382 | 3,900 | SH | DFND | 2 | 3,900 | 0 | 0 | |
PENUMBRA INC | COM | 70975L107 | 48,671 | 179,875 | SH | DFND | 2 | 179,875 | 0 | 0 | |
PERKINELMER INC | COM | 714046109 | 282 | 2,200 | SH | DFND | 2 | 2,200 | 0 | 0 | |
PHREESIA INC | COM | 71944F106 | 31,938 | 613,013 | SH | DFND | 2 | 613,013 | 0 | 0 | |
POOL CORP | COM | 73278L105 | 311 | 900 | SH | DFND | 2 | 900 | 0 | 0 | |
PULMONX CORP | COM | 745848101 | 8,074 | 176,510 | SH | DFND | 2 | 176,510 | 0 | 0 | |
QUANTERIX CORP | COM | 74766Q101 | 40,779 | 697,432 | SH | DFND | 2 | 697,432 | 0 | 0 | |
RADIUS HEALTH INC | COM NEW | 750469207 | 1,579 | 75,700 | SH | DFND | 2 | 75,700 | 0 | 0 | |
RADIUS HEALTH INC | COM NEW | 750469207 | 155,526 | 7,455,714 | SH | DFND | 1,2 | 7,455,714 | 0 | 0 | |
REGENERON PHARMACEUTICALS | COM | 75886F107 | 16,938 | 35,800 | SH | DFND | 2 | 35,800 | 0 | 0 | |
RELAY THERAPEUTICS INC | COM | 75943R102 | 66,767 | 1,931,344 | SH | DFND | 1,2 | 1,931,344 | 0 | 0 | |
RESMED INC | COM | 761152107 | 17,102 | 88,145 | SH | DFND | 2 | 88,145 | 0 | 0 | |
REVOLUTION MEDICINES INC | COM | 76155X100 | 2,661 | 58,000 | SH | DFND | 2 | 58,000 | 0 | 0 | |
REVOLUTION MEDICINES INC | COM | 76155X100 | 46,236 | 1,007,770 | SH | DFND | 1,2 | 1,007,770 | 0 | 0 | |
S&P GLOBAL INC | COM | 78409V104 | 423 | 1,200 | SH | DFND | 2 | 1,200 | 0 | 0 | |
SAGE THERAPEUTICS INC | COM | 78667J108 | 2,665 | 35,600 | SH | DFND | 2 | 35,600 | 0 | 0 | |
SAGE THERAPEUTICS INC | COM | 78667J108 | 132,867 | 1,775,104 | SH | DFND | 1,2 | 1,775,104 | 0 | 0 | |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 1,513 | 20,300 | SH | DFND | 2 | 20,300 | 0 | 0 | |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 1,570 | 31,000 | SH | DFND | 2 | 31,000 | 0 | 0 | |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 106,392 | 2,100,125 | SH | DFND | 1,2 | 2,100,125 | 0 | 0 | |
SEAGEN INC | COM | 81181C104 | 4,902 | 35,300 | SH | DFND | 2 | 35,300 | 0 | 0 | |
SEER INC | COM CL A | 81578P106 | 5,514 | 110,228 | SH | DFND | 2 | 110,228 | 0 | 0 | |
SENSATA TECHNOLOGIES HLDNG PL | SHS | G8060N102 | 342 | 5,900 | SH | DFND | 2 | 5,900 | 0 | 0 | |
SERVICE CORP INTL | COM | 817565104 | 332 | 6,500 | SH | DFND | 2 | 6,500 | 0 | 0 | |
SHOCKWAVE MED INC | COM | 82489T104 | 63,119 | 484,564 | SH | DFND | 2 | 484,564 | 0 | 0 | |
SIGNIFY HEALTH INC | CL A COM | 82671G100 | 5,852 | 200,000 | SH | DFND | 2 | 200,000 | 0 | 0 | |
SILK RD MED INC | COM | 82710M100 | 24,560 | 484,893 | SH | DFND | 2 | 484,893 | 0 | 0 | |
SILK RD MED INC | COM | 82710M100 | 34,140 | 674,031 | SH | DFND | 3 | 674,031 | 0 | 0 | |
SKYWORKS SOLUTIONS INC | COM | 83088M102 | 385 | 2,100 | SH | DFND | 2 | 2,100 | 0 | 0 | |
STARBUCKS CORP | COM | 855244109 | 353 | 3,234 | SH | DFND | 2 | 3,234 | 0 | 0 | |
STONECO LTD | COM CL A | G85158106 | 263 | 4,300 | SH | DFND | 2 | 4,300 | 0 | 0 | |
STRYKER CORPORATION | COM | 863667101 | 83,917 | 344,514 | SH | DFND | 2 | 344,514 | 0 | 0 | |
SYNEOS HEALTH INC | CL A | 87166B102 | 1,441 | 19,000 | SH | DFND | 2 | 19,000 | 0 | 0 | |
TABULA RASA HEALTHCARE INC | COM | 873379101 | 10,462 | 227,178 | SH | DFND | 2 | 227,178 | 0 | 0 | |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 41,130 | 466,063 | SH | DFND | 2 | 466,063 | 0 | 0 | |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 5,390 | 61,071 | SH | DFND | 3 | 61,071 | 0 | 0 | |
TELADOC HEALTH INC | COM | 87918A105 | 46,269 | 254,577 | SH | DFND | 2 | 254,577 | 0 | 0 | |
TELEFLEX INCORPORATED | COM | 879369106 | 50,421 | 121,361 | SH | DFND | 2 | 121,361 | 0 | 0 | |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 16,692 | 36,574 | SH | DFND | 2 | 36,574 | 0 | 0 | |
TRADEWEB MKTS INC | CL A | 892672106 | 385 | 5,200 | SH | DFND | 2 | 5,200 | 0 | 0 | |
TRANSMEDICS GROUP INC | COM | 89377M109 | 30,794 | 742,200 | SH | DFND | 2 | 742,200 | 0 | 0 | |
TRANSUNION | COM | 89400J107 | 333 | 3,696 | SH | DFND | 2 | 3,696 | 0 | 0 | |
TRIMBLE INC | COM | 896239100 | 373 | 4,800 | SH | DFND | 2 | 4,800 | 0 | 0 | |
TRIP COM GROUP LTD | ADS | 89677Q107 | 396 | 10,000 | SH | DFND | 2 | 10,000 | 0 | 0 | |
TYLER TECHNOLOGIES INC | COM | 902252105 | 340 | 800 | SH | DFND | 2 | 800 | 0 | 0 | |
ULTA BEAUTY INC | COM | 90384S303 | 340 | 1,100 | SH | DFND | 2 | 1,100 | 0 | 0 | |
ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 4,668 | 41,000 | SH | DFND | 2 | 41,000 | 0 | 0 | |
UNIQURE NV | SHS | N90064101 | 1,162 | 34,500 | SH | DFND | 2 | 34,500 | 0 | 0 | |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 83,693 | 224,938 | SH | DFND | 2 | 224,938 | 0 | 0 | |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 49,278 | 132,443 | SH | DFND | 3 | 132,443 | 0 | 0 | |
UNIVERSAL DISPLAY CORP | COM | 91347P105 | 323 | 1,365 | SH | DFND | 2 | 1,365 | 0 | 0 | |
VEEVA SYS INC | CL A COM | 922475108 | 39,917 | 152,800 | SH | DFND | 2 | 152,800 | 0 | 0 | |
VERISIGN INC | COM | 92343E102 | 338 | 1,700 | SH | DFND | 2 | 1,700 | 0 | 0 | |
VERISK ANALYTICS INC | COM | 92345Y106 | 307 | 1,739 | SH | DFND | 2 | 1,739 | 0 | 0 | |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 18,824 | 87,600 | SH | DFND | 2 | 87,600 | 0 | 0 | |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 83,615 | 389,104 | SH | DFND | 3 | 389,104 | 0 | 0 | |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 193,401 | 900,000 | SH | DFND | 1,2 | 900,000 | 0 | 0 | |
VOCERA COMMUNICATONS INC | COM | 92857F107 | 18,926 | 492,107 | SH | DFND | 2 | 492,107 | 0 | 0 | |
VOYAGER THERAPEUTICS INC | COM | 92915B106 | 150 | 31,800 | SH | DFND | 2 | 31,800 | 0 | 0 | |
WABTEC | COM | 929740108 | 332 | 4,200 | SH | DFND | 2 | 4,200 | 0 | 0 | |
WATSCO INC | COM | 942622200 | 339 | 1,300 | SH | DFND | 2 | 1,300 | 0 | 0 | |
WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 14,602 | 2,602,858 | SH | DFND | 1,2 | 2,602,858 | 0 | 0 | |
XENCOR INC | COM | 98401F105 | 2,286 | 53,100 | SH | DFND | 2 | 53,100 | 0 | 0 | |
ZAI LAB LTD | ADR | 98887Q104 | 11,542 | 86,500 | SH | DFND | 2 | 86,500 | 0 | 0 | |
ZIMMER BIOMET HOLDINGS INC | COM | 98956P102 | 44,836 | 280,082 | SH | DFND | 2 | 280,082 | 0 | 0 |