The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
1LIFE HEALTHCARE INC | COM | 68269G107 | 14,692 | 836,190 | SH | DFND | 2 | 836,190 | 0 | 0 | |
10X GENOMICS INC | CL A COM | 88025U109 | 34,659 | 232,672 | SH | DFND | 2 | 232,672 | 0 | 0 | |
ABBOTT LABS | COM | 002824100 | 245,704 | 1,745,801 | SH | DFND | 2 | 1,745,801 | 0 | 0 | |
ABBVIE INC | COM | 00287Y109 | 41,554 | 306,900 | SH | DFND | 2 | 306,900 | 0 | 0 | |
ABIOMED INC | COM | 003654100 | 53,939 | 150,178 | SH | DFND | 2 | 150,178 | 0 | 0 | |
ACCOLADE INC | COM | 00437E102 | 18,148 | 688,479 | SH | DFND | 2 | 688,479 | 0 | 0 | |
ACCOLADE INC | COM | 00437E102 | 53,587 | 2,032,896 | SH | DFND | 3 | 2,032,896 | 0 | 0 | |
ADAPTIVE BIOTECHNOLOGIES COR | COM | 00650F109 | 55,234 | 1,968,431 | SH | DFND | 3 | 1,968,431 | 0 | 0 | |
AGILENT TECHNOLOGIES INC | COM | 00846U101 | 160 | 1,000 | SH | DFND | 2 | 1,000 | 0 | 0 | |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 1,216 | 37,000 | SH | DFND | 2 | 37,000 | 0 | 0 | |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 141,745 | 4,312,292 | SH | DFND | 1,2 | 4,312,292 | 0 | 0 | |
ALIGN TECHNOLOGY INC | COM | 016255101 | 96,319 | 146,564 | SH | DFND | 2 | 146,564 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 8,564 | 50,500 | SH | DFND | 2 | 50,500 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 188,234 | 1,110,000 | SH | DFND | 1,2 | 1,110,000 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 29,615 | 174,640 | SH | DFND | 3 | 174,640 | 0 | 0 | |
AMEDISYS INC | COM | 023436108 | 12,590 | 77,773 | SH | DFND | 2 | 77,773 | 0 | 0 | |
AMEDISYS INC | COM | 023436108 | 66,733 | 412,239 | SH | DFND | 3 | 412,239 | 0 | 0 | |
AMERICAN EXPRESS CO | COM | 025816109 | 245 | 1,500 | SH | DFND | 2 | 1,500 | 0 | 0 | |
AMERICAN WELL CORP | CL A | 03044L105 | 12,852 | 2,127,838 | SH | DFND | 2 | 2,127,838 | 0 | 0 | |
AMGEN INC | COM | 031162100 | 13,082 | 58,150 | SH | DFND | 2 | 58,150 | 0 | 0 | |
ANTHEM INC | COM | 036752103 | 126,413 | 272,713 | SH | DFND | 2 | 272,713 | 0 | 0 | |
ANTHEM INC | COM | 036752103 | 84,634 | 182,581 | SH | DFND | 3 | 182,581 | 0 | 0 | |
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 2,269 | 48,000 | SH | DFND | 2 | 48,000 | 0 | 0 | |
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 28,491 | 602,591 | SH | DFND | 3 | 602,591 | 0 | 0 | |
ARCTURUS THERAPEUTICS HLDGS | COM | 03969T109 | 1,540 | 41,600 | SH | DFND | 2 | 41,600 | 0 | 0 | |
ARCUS BIOSCIENCES INC | COM | 03969F109 | 3,541 | 87,500 | SH | DFND | 2 | 87,500 | 0 | 0 | |
ARGENX SE | SPONSORED ADR | 04016X101 | 9,280 | 26,500 | SH | DFND | 2 | 26,500 | 0 | 0 | |
ARGENX SE | SPONSORED ADR | 04016X101 | 339,873 | 970,538 | SH | DFND | 1,2 | 970,538 | 0 | 0 | |
ARVINAS INC | COM | 04335A105 | 4,641 | 56,500 | SH | DFND | 2 | 56,500 | 0 | 0 | |
ARVINAS INC | COM | 04335A105 | 178,811 | 2,176,903 | SH | DFND | 1,2 | 2,176,903 | 0 | 0 | |
ASPEN TECHNOLOGY INC | COM | 045327103 | 285 | 1,874 | SH | DFND | 2 | 1,874 | 0 | 0 | |
ASTRAZENECA PLC | SPONSORED ADR | 046353108 | 3,437 | 59,000 | SH | DFND | 2 | 59,000 | 0 | 0 | |
ATRICURE INC | COM | 04963C209 | 34,665 | 498,556 | SH | DFND | 3 | 498,556 | 0 | 0 | |
AVALARA INC | COM | 05338G106 | 168 | 1,300 | SH | DFND | 2 | 1,300 | 0 | 0 | |
AVANTOR INC | COM | 05352A100 | 21,585 | 512,216 | SH | DFND | 2 | 512,216 | 0 | 0 | |
AXONICS INC | COM | 05465P101 | 55,876 | 997,790 | SH | DFND | 2 | 997,790 | 0 | 0 | |
AXONICS INC | COM | 05465P101 | 48,957 | 874,224 | SH | DFND | 3 | 874,224 | 0 | 0 | |
AXSOME THERAPEUTICS INC | COM | 05464T104 | 24,630 | 651,937 | SH | DFND | 3 | 651,937 | 0 | 0 | |
BAXTER INTL INC | COM | 071813109 | 38,615 | 449,849 | SH | DFND | 2 | 449,849 | 0 | 0 | |
BEAM THERAPEUTICS INC | COM | 07373V105 | 478 | 6,000 | SH | DFND | 2 | 6,000 | 0 | 0 | |
BEAM THERAPEUTICS INC | COM | 07373V105 | 48,358 | 606,821 | SH | DFND | 1,2 | 606,821 | 0 | 0 | |
BECTON DICKINSON & CO | COM | 075887109 | 114,527 | 455,412 | SH | DFND | 2 | 455,412 | 0 | 0 | |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 6,231 | 23,000 | SH | DFND | 2 | 23,000 | 0 | 0 | |
BERKELEY LTS INC | COM | 084310101 | 7,000 | 385,014 | SH | DFND | 2 | 385,014 | 0 | 0 | |
BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 | 3,269 | 53,700 | SH | DFND | 2 | 53,700 | 0 | 0 | |
BIOGEN INC | COM | 09062X103 | 5,998 | 25,000 | SH | DFND | 2 | 25,000 | 0 | 0 | |
BIOGEN INC | COM | 09062X103 | 119,960 | 500,000 | SH | DFND | 1,2 | 500,000 | 0 | 0 | |
BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 5,238 | 38,007 | SH | DFND | 2 | 38,007 | 0 | 0 | |
BIONTECH SE | SPONSORED ADS | 09075V102 | 29,252 | 113,466 | SH | DFND | 2 | 113,466 | 0 | 0 | |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 6,308 | 71,400 | SH | DFND | 2 | 71,400 | 0 | 0 | |
BIO RAD LABS INC | CL A | 090572207 | 29,983 | 39,683 | SH | DFND | 3 | 39,683 | 0 | 0 | |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 123 | 23,000 | SH | DFND | 2 | 23,000 | 0 | 0 | |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 18,335 | 3,440,000 | SH | DFND | 1,2 | 3,440,000 | 0 | 0 | |
BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 2,731 | 25,500 | SH | DFND | 2 | 25,500 | 0 | 0 | |
BOSTON SCIENTIFIC CORP | COM | 101137107 | 125,912 | 2,964,031 | SH | DFND | 2 | 2,964,031 | 0 | 0 | |
BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 66,050 | 1,059,347 | SH | DFND | 3 | 1,059,347 | 0 | 0 | |
BURNING ROCK BIOTECH LTD | SPONSORED ADS | 12233L107 | 4,669 | 489,890 | SH | DFND | 2 | 489,890 | 0 | 0 | |
C4 THERAPEUTICS INC | COM STK | 12529R107 | 1,520 | 47,200 | SH | DFND | 2 | 47,200 | 0 | 0 | |
CAREDX INC | COM | 14167L103 | 66,699 | 1,466,552 | SH | DFND | 3 | 1,466,552 | 0 | 0 | |
CATALENT INC | COM | 148806102 | 2,957 | 23,100 | SH | DFND | 2 | 23,100 | 0 | 0 | |
CELLECTIS S A | SPON ADS | 15117K103 | 670 | 82,500 | SH | DFND | 2 | 82,500 | 0 | 0 | |
CENTENE CORP DEL | COM | 15135B101 | 54,385 | 660,010 | SH | DFND | 2 | 660,010 | 0 | 0 | |
CHARLES RIV LABS INTL INC | COM | 159864107 | 24,834 | 65,911 | SH | DFND | 3 | 65,911 | 0 | 0 | |
CIGNA CORP NEW | COM | 125523100 | 56,299 | 245,174 | SH | DFND | 2 | 245,174 | 0 | 0 | |
CLOROX CO DEL | COM | 189054109 | 209 | 1,200 | SH | DFND | 2 | 1,200 | 0 | 0 | |
COOPER COS INC | COM NEW | 216648402 | 34,906 | 83,319 | SH | DFND | 2 | 83,319 | 0 | 0 | |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 1,902 | 25,100 | SH | DFND | 2 | 25,100 | 0 | 0 | |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 71,959 | 949,584 | SH | DFND | 1,2 | 949,584 | 0 | 0 | |
CVS HEALTH CORP | COM | 126650100 | 23,603 | 228,798 | SH | DFND | 2 | 228,798 | 0 | 0 | |
CYBERARK SOFTWARE LTD | SHS | M2682V108 | 364 | 2,100 | SH | DFND | 2 | 2,100 | 0 | 0 | |
DANAHER CORPORATION | COM | 235851102 | 194,708 | 591,800 | SH | DFND | 2 | 591,800 | 0 | 0 | |
DENTSPLY SIRONA INC | COM | 24906P109 | 8,878 | 159,129 | SH | DFND | 2 | 159,129 | 0 | 0 | |
DEXCOM INC | COM | 252131107 | 126,265 | 235,153 | SH | DFND | 2 | 235,153 | 0 | 0 | |
DOLBY LABORATORIES INC | COM CL A | 25659T107 | 343 | 3,600 | SH | DFND | 2 | 3,600 | 0 | 0 | |
DR REDDYS LABS LTD | ADR | 256135203 | 556 | 8,500 | SH | DFND | 2 | 8,500 | 0 | 0 | |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 119,340 | 921,185 | SH | DFND | 2 | 921,185 | 0 | 0 | |
ELECTRONIC ARTS INC | COM | 285512109 | 299 | 2,270 | SH | DFND | 2 | 2,270 | 0 | 0 | |
ENTEGRIS INC | COM | 29362U104 | 416 | 3,000 | SH | DFND | 2 | 3,000 | 0 | 0 | |
EQUINIX INC | COM | 29444U700 | 34 | 40 | SH | DFND | 2 | 40 | 0 | 0 | |
ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 206 | 41,200 | SH | DFND | 2 | 41,200 | 0 | 0 | |
ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 22,390 | 4,477,964 | SH | DFND | 1,2 | 4,477,964 | 0 | 0 | |
ESSA PHARMA INC | COM NEW | 29668H708 | 270 | 19,000 | SH | DFND | 2 | 19,000 | 0 | 0 | |
ESSA PHARMA INC | COM NEW | 29668H708 | 71,225 | 5,015,814 | SH | DFND | 1,2 | 5,015,814 | 0 | 0 | |
EVERTEC INC | COM | 30040P103 | 37 | 739 | SH | DFND | 2 | 739 | 0 | 0 | |
EVOLENT HEALTH INC | CL A | 30050B101 | 31,372 | 1,133,786 | SH | DFND | 2 | 1,133,786 | 0 | 0 | |
EVOLENT HEALTH INC | CL A | 30050B101 | 40,827 | 1,475,507 | SH | DFND | 3 | 1,475,507 | 0 | 0 | |
EXACT SCIENCES CORP | COM | 30063P105 | 50,012 | 642,582 | SH | DFND | 3 | 642,582 | 0 | 0 | |
EXELIXIS INC | COM | 30161Q104 | 439 | 24,000 | SH | DFND | 2 | 24,000 | 0 | 0 | |
EXELIXIS INC | COM | 30161Q104 | 51,824 | 2,835,000 | SH | DFND | 1,2 | 2,835,000 | 0 | 0 | |
FATE THERAPEUTICS INC | COM | 31189P102 | 4,353 | 74,400 | SH | DFND | 2 | 74,400 | 0 | 0 | |
FATE THERAPEUTICS INC | COM | 31189P102 | 216,565 | 3,701,336 | SH | DFND | 1,2 | 3,701,336 | 0 | 0 | |
FORTINET INC | COM | 34959E109 | 289 | 803 | SH | DFND | 2 | 803 | 0 | 0 | |
GENERATION BIO CO | COM | 37148K100 | 135 | 19,000 | SH | DFND | 2 | 19,000 | 0 | 0 | |
GENERATION BIO CO | COM | 37148K100 | 27,281 | 3,853,180 | SH | DFND | 1,2 | 3,853,180 | 0 | 0 | |
GENETRON HLDGS LTD | ADS | 37186H100 | 4,411 | 723,137 | SH | DFND | 2 | 723,137 | 0 | 0 | |
GILEAD SCIENCES INC | COM | 375558103 | 11,400 | 157,000 | SH | DFND | 2 | 157,000 | 0 | 0 | |
GLOBUS MED INC | CL A | 379577208 | 54,689 | 757,464 | SH | DFND | 2 | 757,464 | 0 | 0 | |
GRACO INC | COM | 384109104 | 363 | 4,500 | SH | DFND | 2 | 4,500 | 0 | 0 | |
GRUPO AEROPORTUARIO DEL SURE | SPON ADR SER B | 40051E202 | 28 | 135 | SH | DFND | 2 | 135 | 0 | 0 | |
GUARDANT HEALTH INC | COM | 40131M109 | 29,367 | 293,612 | SH | DFND | 2 | 293,612 | 0 | 0 | |
HALOZYME THERAPEUTICS INC | COM | 40637H109 | 42,924 | 1,067,500 | SH | DFND | 2 | 1,067,500 | 0 | 0 | |
HARMONY BIOSCIENCES HLDGS IN | COM | 413197104 | 5,166 | 121,161 | SH | DFND | 2 | 121,161 | 0 | 0 | |
HCA HEALTHCARE INC | COM | 40412C101 | 75,646 | 294,434 | SH | DFND | 2 | 294,434 | 0 | 0 | |
HEALTH CATALYST INC | COM | 42225T107 | 27,443 | 692,666 | SH | DFND | 2 | 692,666 | 0 | 0 | |
HOLOGIC INC | COM | 436440101 | 34,888 | 455,701 | SH | DFND | 2 | 455,701 | 0 | 0 | |
HOLOGIC INC | COM | 436440101 | 9,472 | 123,723 | SH | DFND | 3 | 123,723 | 0 | 0 | |
HOMOLOGY MEDICINES INC | COM | 438083107 | 6,323 | 1,737,122 | SH | DFND | 1,2 | 1,737,122 | 0 | 0 | |
HORIZON THERAPEUTICS PUB L | SHS | G46188101 | 39,720 | 368,600 | SH | DFND | 2 | 368,600 | 0 | 0 | |
HUMANA INC | COM | 444859102 | 63,508 | 136,912 | SH | DFND | 2 | 136,912 | 0 | 0 | |
HUMANA INC | COM | 444859102 | 77,365 | 166,785 | SH | DFND | 3 | 166,785 | 0 | 0 | |
HUTCHMED CHINA LTD | SPONSORED ADS | 44842L103 | 37,777 | 1,076,870 | SH | DFND | 3 | 1,076,870 | 0 | 0 | |
IDEAYA BIOSCIENCES INC | COM | 45166A102 | 1,111 | 47,000 | SH | DFND | 2 | 47,000 | 0 | 0 | |
IDEXX LABS INC | COM | 45168D104 | 77,684 | 117,979 | SH | DFND | 2 | 117,979 | 0 | 0 | |
ILLUMINA INC | COM | 452327109 | 28,582 | 75,130 | SH | DFND | 2 | 75,130 | 0 | 0 | |
I MAB | SPONSORED ADS | 44975P103 | 6,870 | 144,957 | SH | DFND | 2 | 144,957 | 0 | 0 | |
INCYTE CORP | COM | 45337C102 | 4,404 | 60,000 | SH | DFND | 2 | 60,000 | 0 | 0 | |
INCYTE CORP | COM | 45337C102 | 212,640 | 2,897,000 | SH | DFND | 1,2 | 2,897,000 | 0 | 0 | |
INFOSYS LTD | SPONSORED ADR | 456788108 | 29 | 1,130 | SH | DFND | 2 | 1,130 | 0 | 0 | |
INHIBRX INC | COM | 45720L107 | 2,205 | 50,500 | SH | DFND | 2 | 50,500 | 0 | 0 | |
INSMED INC | COM PAR $.01 | 457669307 | 95,908 | 3,520,861 | SH | DFND | 3 | 3,520,861 | 0 | 0 | |
INSPIRE MED SYS INC | COM | 457730109 | 96,805 | 420,780 | SH | DFND | 2 | 420,780 | 0 | 0 | |
INSULET CORP | COM | 45784P101 | 101,831 | 382,723 | SH | DFND | 2 | 382,723 | 0 | 0 | |
INTELLIA THERAPEUTICS INC | COM | 45826J105 | 1,962 | 16,594 | SH | DFND | 2 | 16,594 | 0 | 0 | |
INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 4,737 | 90,500 | SH | DFND | 2 | 90,500 | 0 | 0 | |
INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 185,201 | 3,538,419 | SH | DFND | 1,2 | 3,538,419 | 0 | 0 | |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 209,998 | 584,463 | SH | DFND | 2 | 584,463 | 0 | 0 | |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 3,717 | 122,150 | SH | DFND | 2 | 122,150 | 0 | 0 | |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 311,389 | 10,232,973 | SH | DFND | 1,2 | 10,232,973 | 0 | 0 | |
IPG PHOTONICS CORP | COM | 44980X109 | 181 | 1,050 | SH | DFND | 2 | 1,050 | 0 | 0 | |
IQVIA HLDGS INC | COM | 46266C105 | 46,136 | 163,520 | SH | DFND | 2 | 163,520 | 0 | 0 | |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 112,985 | 886,854 | SH | DFND | 3 | 886,854 | 0 | 0 | |
JD.COM INC | SPON ADR CL A | 47215P106 | 252 | 3,600 | SH | DFND | 2 | 3,600 | 0 | 0 | |
JOHNSON & JOHNSON | COM | 478160104 | 3,456 | 20,200 | SH | DFND | 2 | 20,200 | 0 | 0 | |
JUMIA TECHNOLOGIES AG | SPONSORED ADS | 48138M105 | 205 | 18,000 | SH | DFND | 2 | 18,000 | 0 | 0 | |
KEZAR LIFE SCIENCES INC | COM | 49372L100 | 82,231 | 4,918,148 | SH | DFND | 1,2 | 4,918,148 | 0 | 0 | |
KOSMOS ENERGY LTD | COM | 500688106 | 1,010 | 292,000 | SH | DFND | 2 | 292,000 | 0 | 0 | |
KRYSTAL BIOTECH INC | COM | 501147102 | 979 | 14,000 | SH | DFND | 2 | 14,000 | 0 | 0 | |
KYMERA THERAPEUTICS INC | COM | 501575104 | 3,111 | 49,000 | SH | DFND | 2 | 49,000 | 0 | 0 | |
LABORATORY CORP AMER HLDGS | COM NEW | 50540R409 | 2,655 | 8,450 | SH | DFND | 2 | 8,450 | 0 | 0 | |
LAUDER ESTEE COS INC | CL A | 518439104 | 499 | 1,348 | SH | DFND | 2 | 1,348 | 0 | 0 | |
LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 | 30,653 | 657,656 | SH | DFND | 2 | 657,656 | 0 | 0 | |
LILLY ELI & CO | COM | 532457108 | 2,086 | 7,552 | SH | DFND | 2 | 7,552 | 0 | 0 | |
LIVE NATION ENTERTAINMENT IN | COM | 538034109 | 563 | 4,700 | SH | DFND | 2 | 4,700 | 0 | 0 | |
MACROGENICS INC | COM | 556099109 | 802 | 49,950 | SH | DFND | 2 | 49,950 | 0 | 0 | |
MACROGENICS INC | COM | 556099109 | 116,773 | 7,275,564 | SH | DFND | 1,2 | 7,275,564 | 0 | 0 | |
MACROGENICS INC | COM | 556099109 | 19,821 | 1,234,948 | SH | DFND | 3 | 1,234,948 | 0 | 0 | |
MARKEL CORP | COM | 570535104 | 370 | 300 | SH | DFND | 2 | 300 | 0 | 0 | |
MARKETAXESS HLDGS INC | COM | 57060D108 | 272 | 662 | SH | DFND | 2 | 662 | 0 | 0 | |
MASIMO CORP | COM | 574795100 | 38,464 | 131,376 | SH | DFND | 2 | 131,376 | 0 | 0 | |
MCKESSON CORP | COM | 58155Q103 | 586 | 2,359 | SH | DFND | 2 | 2,359 | 0 | 0 | |
MEDTRONIC PLC | SHS | G5960L103 | 69,043 | 667,408 | SH | DFND | 2 | 667,408 | 0 | 0 | |
MERCADOLIBRE INC | COM | 58733R102 | 229 | 170 | SH | DFND | 2 | 170 | 0 | 0 | |
MERSANA THERAPEUTICS INC | COM | 59045L106 | 180 | 29,000 | SH | DFND | 2 | 29,000 | 0 | 0 | |
MERSANA THERAPEUTICS INC | COM | 59045L106 | 25,720 | 4,135,000 | SH | DFND | 1,2 | 4,135,000 | 0 | 0 | |
MIRATI THERAPEUTICS INC | COM | 60468T105 | 3,169 | 21,600 | SH | DFND | 2 | 21,600 | 0 | 0 | |
MODERNA INC | COM | 60770K107 | 11,658 | 45,900 | SH | DFND | 2 | 45,900 | 0 | 0 | |
MODERNA INC | COM | 60770K107 | 422,457 | 1,663,349 | SH | DFND | 1,2 | 1,663,349 | 0 | 0 | |
MOLECULAR TEMPLATES INC | COM | 608550109 | 337 | 86,000 | SH | DFND | 2 | 86,000 | 0 | 0 | |
MOLECULAR TEMPLATES INC | COM | 608550109 | 42,305 | 10,792,003 | SH | DFND | 1,2 | 10,792,003 | 0 | 0 | |
MOLINA HEALTHCARE INC | COM | 60855R100 | 100,062 | 314,582 | SH | DFND | 2 | 314,582 | 0 | 0 | |
MYOVANT SCIENCES LTD | COM | G637AM102 | 732 | 47,000 | SH | DFND | 2 | 47,000 | 0 | 0 | |
MYOVANT SCIENCES LTD | COM | G637AM102 | 95,320 | 6,122,039 | SH | DFND | 1,2 | 6,122,039 | 0 | 0 | |
NEKTAR THERAPEUTICS | COM | 640268108 | 389 | 28,800 | SH | DFND | 2 | 28,800 | 0 | 0 | |
NEKTAR THERAPEUTICS | COM | 640268108 | 35,405 | 2,620,676 | SH | DFND | 1,2 | 2,620,676 | 0 | 0 | |
NEKTAR THERAPEUTICS | COM | 640268108 | 24,348 | 1,802,217 | SH | DFND | 3 | 1,802,217 | 0 | 0 | |
NEOGENOMICS INC | COM NEW | 64049M209 | 16,026 | 469,695 | SH | DFND | 3 | 469,695 | 0 | 0 | |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 14,066 | 165,151 | SH | DFND | 2 | 165,151 | 0 | 0 | |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 256,822 | 3,015,400 | SH | DFND | 1,2 | 3,015,400 | 0 | 0 | |
NEUROPACE INC | COM | 641288105 | 5,120 | 507,930 | SH | DFND | 2 | 507,930 | 0 | 0 | |
NEVRO CORP | COM | 64157F103 | 19,282 | 237,841 | SH | DFND | 2 | 237,841 | 0 | 0 | |
NEW YORK TIMES CO | CL A | 650111107 | 362 | 7,500 | SH | DFND | 2 | 7,500 | 0 | 0 | |
NIO INC | SPON ADS | 62914V106 | 25 | 780 | SH | DFND | 2 | 780 | 0 | 0 | |
NOVAVAX INC | COM NEW | 670002401 | 1,488 | 10,400 | SH | DFND | 2 | 10,400 | 0 | 0 | |
OLINK HLDG AB | SPONSORED ADS | 680710100 | 4,282 | 235,273 | SH | DFND | 2 | 235,273 | 0 | 0 | |
OMNICELL INC | COM | 68213N109 | 65,379 | 362,332 | SH | DFND | 2 | 362,332 | 0 | 0 | |
OPTHEA LTD | SPONSORED ADS | 68386J208 | 368 | 49,000 | SH | DFND | 2 | 49,000 | 0 | 0 | |
OPTION CARE HEALTH INC | COM NEW | 68404L201 | 83,160 | 2,924,043 | SH | DFND | 3 | 2,924,043 | 0 | 0 | |
OSCAR HEALTH INC | CL A | 687793109 | 5,338 | 679,952 | SH | DFND | 2 | 679,952 | 0 | 0 | |
OUTSET MED INC | COM | 690145107 | 25,838 | 560,606 | SH | DFND | 2 | 560,606 | 0 | 0 | |
PACIFIC BIOSIENCES CALIF IN | COM | 69404D108 | 31,775 | 1,553,023 | SH | DFND | 2 | 1,553,023 | 0 | 0 | |
PENUMBRA INC | COM | 70975L107 | 55,664 | 193,734 | SH | DFND | 2 | 193,734 | 0 | 0 | |
PFIZER INC | COM | 717081103 | 6,673 | 113,000 | SH | DFND | 2 | 113,000 | 0 | 0 | |
PHREESIA INC | COM | 71944F106 | 24,676 | 592,327 | SH | DFND | 2 | 592,327 | 0 | 0 | |
PRIVIA HEALTH GROUP INC | COM | 74276R102 | 13,582 | 525,000 | SH | DFND | 2 | 525,000 | 0 | 0 | |
PROCEPT BIOROBOTICS CORP | COM | 74276L105 | 4,343 | 173,649 | SH | DFND | 2 | 173,649 | 0 | 0 | |
PULMONX CORP | COM | 745848101 | 5,661 | 176,510 | SH | DFND | 2 | 176,510 | 0 | 0 | |
QUANTERIX CORP | COM | 74766Q101 | 16,852 | 397,464 | SH | DFND | 2 | 397,464 | 0 | 0 | |
QUEST DIAGNOSTICS INC | COM | 74834L100 | 2,638 | 15,250 | SH | DFND | 2 | 15,250 | 0 | 0 | |
RADIUS HEALTH INC | COM NEW | 750469207 | 436 | 63,000 | SH | DFND | 2 | 63,000 | 0 | 0 | |
RADIUS HEALTH INC | COM NEW | 750469207 | 53,324 | 7,705,714 | SH | DFND | 1,2 | 7,705,714 | 0 | 0 | |
REGENERON PHARMACEUTICALS | COM | 75886F107 | 58,769 | 93,060 | SH | DFND | 2 | 93,060 | 0 | 0 | |
RELAY THERAPEUTICS INC | COM | 75943R102 | 614 | 20,000 | SH | DFND | 2 | 20,000 | 0 | 0 | |
RELAY THERAPEUTICS INC | COM | 75943R102 | 125,480 | 4,085,962 | SH | DFND | 1,2 | 4,085,962 | 0 | 0 | |
RESMED INC | COM | 761152107 | 22,529 | 86,490 | SH | DFND | 2 | 86,490 | 0 | 0 | |
REVOLUTION MEDICINES INC | COM | 76155X100 | 1,226 | 48,700 | SH | DFND | 2 | 48,700 | 0 | 0 | |
REVOLUTION MEDICINES INC | COM | 76155X100 | 86,118 | 3,421,462 | SH | DFND | 1,2 | 3,421,462 | 0 | 0 | |
SAGE THERAPEUTICS INC | COM | 78667J108 | 2,463 | 57,900 | SH | DFND | 2 | 57,900 | 0 | 0 | |
SAGE THERAPEUTICS INC | COM | 78667J108 | 134,856 | 3,170,104 | SH | DFND | 1,2 | 3,170,104 | 0 | 0 | |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 74,448 | 826,741 | SH | DFND | 3 | 826,741 | 0 | 0 | |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 479 | 19,300 | SH | DFND | 2 | 19,300 | 0 | 0 | |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 56,514 | 2,275,125 | SH | DFND | 1,2 | 2,275,125 | 0 | 0 | |
SEAGEN INC | COM | 81181C104 | 7,112 | 46,000 | SH | DFND | 2 | 46,000 | 0 | 0 | |
SEER INC | COM CL A | 81578P106 | 3,105 | 136,133 | SH | DFND | 2 | 136,133 | 0 | 0 | |
SHOCKWAVE MED INC | COM | 82489T104 | 76,077 | 426,610 | SH | DFND | 2 | 426,610 | 0 | 0 | |
SIGHT SCIENCES INC | COM | 82657M105 | 5,271 | 300,000 | SH | DFND | 2 | 300,000 | 0 | 0 | |
SILENCE THERAPEUTICS PLC | ADS | 82686Q101 | 1,092 | 46,666 | SH | DFND | 2 | 46,666 | 0 | 0 | |
SILK RD MED INC | COM | 82710M100 | 40,583 | 952,433 | SH | DFND | 3 | 952,433 | 0 | 0 | |
SKYWORKS SOLUTIONS INC | COM | 83088M102 | 326 | 2,100 | SH | DFND | 2 | 2,100 | 0 | 0 | |
SPOTIFY TECHNOLOGY SA | SHS | L8681T102 | 257 | 1,100 | SH | DFND | 2 | 1,100 | 0 | 0 | |
STONECO LTD | COM CL A | G85158106 | 72 | 4,300 | SH | DFND | 2 | 4,300 | 0 | 0 | |
STRYKER CORPORATION | COM | 863667101 | 112,820 | 421,884 | SH | DFND | 2 | 421,884 | 0 | 0 | |
SYNEOS HEALTH INC | CL A | 87166B102 | 2,208 | 21,500 | SH | DFND | 2 | 21,500 | 0 | 0 | |
TAIWAN SEMICONDUCTOR MFG LTD | SPONSORED ADS | 874039100 | 42 | 346 | SH | DFND | 2 | 346 | 0 | 0 | |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 80,323 | 533,640 | SH | DFND | 2 | 533,640 | 0 | 0 | |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 62,559 | 415,617 | SH | DFND | 3 | 415,617 | 0 | 0 | |
TELADOC HEALTH INC | COM | 87918A105 | 33,350 | 363,216 | SH | DFND | 2 | 363,216 | 0 | 0 | |
TELEFLEX INCORPORATED | COM | 879369106 | 32,116 | 97,771 | SH | DFND | 2 | 97,771 | 0 | 0 | |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 65,608 | 98,328 | SH | DFND | 2 | 98,328 | 0 | 0 | |
TRANSMEDICS GROUP INC | COM | 89377M109 | 11,133 | 581,029 | SH | DFND | 2 | 581,029 | 0 | 0 | |
ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 1,766 | 21,000 | SH | DFND | 2 | 21,000 | 0 | 0 | |
UNITED MICROELECTRONICS CORP | SPON ADR NEW | 910873405 | 32 | 2,698 | SH | DFND | 2 | 2,698 | 0 | 0 | |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 100,963 | 201,066 | SH | DFND | 2 | 201,066 | 0 | 0 | |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 55,846 | 111,215 | SH | DFND | 3 | 111,215 | 0 | 0 | |
UNIVERSAL DISPLAY CORP | COM | 91347P105 | 225 | 1,365 | SH | DFND | 2 | 1,365 | 0 | 0 | |
VEEVA SYS INC | CL A COM | 922475108 | 42,143 | 164,955 | SH | DFND | 2 | 164,955 | 0 | 0 | |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 60,917 | 277,400 | SH | DFND | 2 | 277,400 | 0 | 0 | |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 106,366 | 484,361 | SH | DFND | 3 | 484,361 | 0 | 0 | |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 226,188 | 1,030,000 | SH | DFND | 1,2 | 1,030,000 | 0 | 0 | |
VOCERA COMMUNICATONS INC | COM | 92857F107 | 33,518 | 516,939 | SH | DFND | 2 | 516,939 | 0 | 0 | |
VOCERA COMMUNICATONS INC | COM | 92857F107 | 41,736 | 643,674 | SH | DFND | 3 | 643,674 | 0 | 0 | |
WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 14,453 | 4,602,858 | SH | DFND | 1,2 | 4,602,858 | 0 | 0 | |
XENCOR INC | COM | 98401F105 | 2,090 | 52,100 | SH | DFND | 2 | 52,100 | 0 | 0 | |
ZAI LAB LTD | ADR | 98887Q104 | 7,957 | 126,600 | SH | DFND | 2 | 126,600 | 0 | 0 | |
ZIMMER BIOMET HOLDINGS INC | COM | 98956P102 | 34,452 | 271,190 | SH | DFND | 2 | 271,190 | 0 | 0 | |
ZOETIS INC | CL A | 98978V103 | 1,733 | 7,100 | SH | DFND | 2 | 7,100 | 0 | 0 |