Consolidated Statements of Stockholders' Equity (USD $) | Total | Preferred Stock [Member] | Common Stock [Member] | Paid in Capital [Member] | Accumulated Deficit [Member] |
Beginning Balance at Jan. 17, 2002 | ' | ' | ' | ' | ' |
Issuance to founding shareholders | ' | ' | $6,000 | ($6,000) | ' |
Issuance to founding shareholders, shares | ' | ' | 6,000,000 | ' | ' |
Sale of stock | 25,000 | ' | 50 | 24,950 | ' |
Sale of stock, shares | ' | ' | 50,000 | ' | ' |
Issuance of stock to employees | 932,000 | ' | 510 | 931,490 | ' |
Issuance of stock to employees, shares | ' | ' | 510,000 | ' | ' |
Issuance of stock for services | 360,000 | ' | 120 | 359,880 | ' |
Issuance of stock for services, shares | ' | ' | 120,000 | ' | ' |
Net loss | -1,316,198 | ' | ' | ' | -1,316,198 |
Ending Balance at Apr. 23, 2002 | 802 | ' | 6,680 | 1,310,320 | -1,316,198 |
Ending Balance, shares at Apr. 23, 2002 | ' | ' | 6,680,000 | ' | ' |
Shares issued in reverse merger | -3,645 | ' | 266 | -3,911 | ' |
Shares issued in reverse merger, shares | ' | ' | 265,763 | ' | ' |
Purchase and retirement of stock | -48,000 | ' | -400 | -47,600 | ' |
Purchase and retirement of stock, shares | ' | ' | -400,000 | ' | ' |
Stock issued for acquisition of Valley Pharmaceuticals | 12,226,320 | ' | 500 | 12,225,820 | ' |
Stock issued for acquisition of Valley Pharmaceuticals, shares | ' | ' | 500,007 | ' | ' |
Exercise of warrants | 453 | ' | 453 | ' | ' |
Issuance of stock for services | 5,144,000 | ' | 1,900 | 5,142,100 | ' |
Exercise of warrants, shares | ' | ' | 452,919 | ' | ' |
Warrants issued in connection with convertible debt | 126,587 | ' | ' | 126,587 | ' |
Issuance of stock for services, shares | ' | ' | 1,900,000 | ' | ' |
Stock and warrants issued for acquisition of Pure-ific | 27,000 | ' | 25 | 26,975 | ' |
Stock and warrants issued for acquisition of Pure-ific, shares | ' | ' | 25,000 | ' | ' |
Net loss | -5,749,937 | ' | ' | ' | -5,749,937 |
Ending Balance at Dec. 31, 2002 | 11,723,580 | ' | 9,424 | 18,780,291 | -7,066,135 |
Ending Balance, shares at Dec. 31, 2002 | ' | ' | 9,423,689 | ' | ' |
Stock to be issued for services | 281,500 | ' | ' | 281,500 | ' |
Issuance of warrants for services | 145,479 | ' | ' | 145,479 | ' |
Issuance of stock pursuant to Regulation S | 380,347 | ' | 680 | 379,667 | ' |
Issuance of stock pursuant to Regulation S, shares | ' | ' | 679,820 | ' | ' |
Issuance of stock for services | 239,800 | ' | 764 | 239,036 | ' |
Issuance of stock for services, shares | ' | ' | 764,000 | ' | ' |
Employee compensation from stock options | 34,659 | ' | ' | 34,659 | ' |
Beneficial conversion related to convertible debt | 601,000 | ' | ' | 601,000 | ' |
Net loss | -3,155,313 | ' | ' | ' | -3,155,313 |
Ending Balance at Dec. 31, 2003 | 10,251,052 | ' | 10,868 | 20,461,632 | -10,221,448 |
Ending Balance, shares at Dec. 31, 2003 | ' | ' | 10,867,509 | ' | ' |
Issuance of warrants for services | 495,480 | ' | ' | 495,480 | ' |
Issuance of stock pursuant to Regulation S | 793,137 | ' | 2,469 | 790,668 | ' |
Issuance of stock pursuant to Regulation S, shares | ' | ' | 2,469,723 | ' | ' |
Exercise of warrants | 5,000 | ' | 133 | 4,867 | ' |
Issuance of stock for services | 449,923 | ' | 734 | 449,190 | ' |
Exercise of warrants, shares | ' | ' | 132,608 | ' | ' |
Issuance of stock for services, shares | ' | ' | 733,872 | ' | ' |
Employee compensation from stock options | 15,612 | ' | ' | 15,612 | ' |
Issuance of convertible debt with warrants | 105,250 | ' | ' | 105,250 | ' |
Issuance of stock and warrants pursuant to Regulation D | 1,288,861 | ' | 1,930 | 1,286,930 | ' |
Issuance of stock and warrants pursuant to Regulation D, shares | ' | ' | 1,930,164 | ' | ' |
Beneficial conversion related to convertible debt | 360,256 | ' | ' | 360,256 | ' |
Repurchase of beneficial conversion feature | -258,345 | ' | ' | -258,345 | ' |
Net loss | -4,344,525 | ' | ' | ' | -4,344,525 |
Ending Balance at Dec. 31, 2004 | 9,161,701 | ' | 16,134 | 23,711,540 | -14,565,973 |
Ending Balance, shares at Dec. 31, 2004 | ' | ' | 16,133,876 | ' | ' |
Issuance of stock for interest payable | 196,031 | ' | 264 | 195,767 | ' |
Issuance of stock for interest payable, shares | ' | ' | 263,721 | ' | ' |
Issuance of warrants for services | 1,534,405 | ' | ' | 1,534,405 | ' |
Issuance of warrants for contractual obligations | 985,010 | ' | ' | 985,010 | ' |
Exercise of warrants and stock options | 1,439,795 | ' | 1,572 | 1,438,223 | ' |
Exercise of warrants and stock options, shares | ' | ' | 1,571,849 | ' | ' |
Issuance of stock for services | 152,285 | ' | 227 | 152,058 | ' |
Issuance of stock for services, shares | ' | ' | 226,733 | ' | ' |
Employee compensation from stock options | 15,752 | ' | ' | 15,752 | ' |
Issuance of convertible debt with warrants | 1,574,900 | ' | ' | 1,574,900 | ' |
Issuance of stock and warrants pursuant to Regulation D | 6,513,176 | ' | 6,221 | 6,506,955 | ' |
Issuance of stock and warrants pursuant to Regulation D, shares | ' | ' | 6,221,257 | ' | ' |
Beneficial conversion related to interest expense | 39,529 | ' | ' | 39,529 | ' |
Preferred stock/Debt conversions into common stock | 3,049,362 | ' | 3,405 | 3,045,957 | ' |
Preferred stock/Debt conversions into common stock, shares | ' | ' | 3,405,541 | ' | ' |
Beneficial conversion related to convertible debt | 1,633,176 | ' | ' | 1,633,176 | ' |
Repurchase of beneficial conversion feature | -144,128 | ' | ' | -144,128 | ' |
Net loss | -11,763,853 | ' | ' | ' | -11,763,853 |
Ending Balance at Dec. 31, 2005 | 14,387,141 | ' | 27,823 | 40,689,144 | -26,329,826 |
Ending Balance, shares at Dec. 31, 2005 | ' | ' | 27,822,977 | ' | ' |
Issuance of stock for interest payable | 183,596 | ' | 195 | 183,401 | ' |
Issuance of stock for interest payable, shares | ' | ' | 194,327 | ' | ' |
Issuance of warrants for services | 370,023 | ' | ' | 370,023 | ' |
Exercise of warrants and stock options | 1,189,816 | ' | 1,246 | 1,188,570 | ' |
Exercise of warrants and stock options, shares | ' | ' | 1,245,809 | ' | ' |
Issuance of stock for services | 676,743 | ' | 719 | 676,024 | ' |
Issuance of stock for services, shares | ' | ' | 719,246 | ' | ' |
Employee compensation from stock options | 1,862,456 | ' | ' | 1,862,456 | ' |
Issuance of stock and warrants pursuant to Regulation D | 4,130,421 | ' | 10,092 | 4,120,329 | ' |
Issuance of stock and warrants pursuant to Regulation D, shares | ' | ' | 10,092,495 | ' | ' |
Beneficial conversion related to interest expense | 16,447 | ' | ' | 16,447 | ' |
Preferred stock/Debt conversions into common stock | 1,576,336 | ' | 2,377 | 1,573,959 | ' |
Preferred stock/Debt conversions into common stock, shares | ' | ' | 2,377,512 | ' | ' |
Net loss | -8,870,579 | ' | ' | ' | -8,870,579 |
Ending Balance at Dec. 31, 2006 | 15,522,400 | ' | 42,452 | 50,680,353 | -35,200,405 |
Ending Balance, shares at Dec. 31, 2006 | ' | ' | 42,452,366 | ' | ' |
Issuance of stock for interest payable | 1,258 | ' | 1 | 1,257 | ' |
Issuance of stock for interest payable, shares | ' | ' | 1,141 | ' | ' |
Issuance of warrants for services | 472,635 | ' | ' | 472,635 | ' |
Exercise of warrants and stock options | 3,985,641 | ' | 3,929 | 3,981,712 | ' |
Exercise of warrants and stock options, shares | ' | ' | 3,928,957 | ' | ' |
Issuance of stock for services | 298,950 | ' | 150 | 298,800 | ' |
Issuance of stock for services, shares | ' | ' | 150,000 | ' | ' |
Employee compensation from stock options | 2,340,619 | ' | ' | 2,340,619 | ' |
Issuance of stock and warrants pursuant to Regulation D | 1,848,138 | ' | 2,377 | 1,845,761 | ' |
Issuance of stock and warrants pursuant to Regulation D, shares | ' | ' | 2,376,817 | ' | ' |
Preferred stock/Debt conversions into common stock | 367,500 | ' | 490 | 367,010 | ' |
Preferred stock/Debt conversions into common stock, shares | ' | ' | 490,000 | ' | ' |
Net loss | -10,005,631 | ' | ' | ' | -10,005,631 |
Ending Balance at Dec. 31, 2007 | 14,831,510 | ' | 49,399 | 59,988,147 | -45,206,036 |
Ending Balance, shares at Dec. 31, 2007 | ' | ' | 49,399,281 | ' | ' |
Issuance of warrants for services | 517,820 | ' | ' | 517,820 | ' |
Exercise of warrants and stock options | 2,639,711 | ' | 3,268 | 2,636,443 | ' |
Exercise of warrants and stock options, shares | ' | ' | 3,267,795 | ' | ' |
Issuance of stock for services | 390,000 | ' | 350 | 389,650 | ' |
Issuance of stock for services, shares | ' | ' | 350,000 | ' | ' |
Employee compensation from stock options | 1,946,066 | ' | ' | 1,946,066 | ' |
Net loss | -10,269,571 | ' | ' | ' | -10,269,571 |
Ending Balance at Dec. 31, 2008 | 10,055,536 | ' | 53,017 | 65,478,126 | -55,475,607 |
Ending Balance, shares at Dec. 31, 2008 | ' | ' | 53,017,076 | ' | ' |
Issuance of warrants for services | 1,064,210 | ' | ' | 1,064,210 | ' |
Exercise of warrants and stock options | 2,524,453 | ' | 3,480 | 2,520,973 | ' |
Exercise of warrants and stock options, shares | ' | ' | 3,480,485 | ' | ' |
Issuance of stock for services | 695,000 | ' | 796 | 694,204 | ' |
Issuance of stock for services, shares | ' | ' | 796,012 | ' | ' |
Employee compensation from stock options | 870,937 | ' | ' | 870,937 | ' |
Issuance of stock and warrants pursuant to Regulation D | 6,518,688 | ' | 10,117 | 6,508,571 | ' |
Issuance of stock and warrants pursuant to Regulation D, shares | ' | ' | 10,116,653 | ' | ' |
Net loss | -12,322,314 | ' | ' | ' | -12,322,314 |
Ending Balance at Dec. 31, 2009 | 9,406,510 | ' | 67,410 | 77,137,021 | -67,797,921 |
Ending Balance, shares at Dec. 31, 2009 | ' | ' | 67,410,226 | ' | ' |
Issuance of warrants for services | 1,141,593 | ' | ' | 1,141,593 | ' |
Issuance of stock pursuant to Regulation S | 419,250 | ' | 559 | 418,691 | ' |
Exercise of warrants and stock options | 3,103,680 | ' | 3,491 | 3,100,189 | ' |
Issuance of stock pursuant to Regulation S, shares | ' | ' | 559,000 | ' | ' |
Exercise of warrants and stock options, shares | ' | ' | 3,491,014 | ' | ' |
Issuance of common stock and warrants pursuant to Regulation D | 6,346,989 | ' | 11,169 | 6,335,820 | ' |
Issuance of common stock and warrants pursuant to Regulation D, shares | ' | ' | 11,168,067 | ' | ' |
Issuance of preferred stock and warrants pursuant to Regulation D | 4,217,390 | 13,283 | ' | 4,204,107 | ' |
Issuance of stock for services | 856,613 | ' | 776 | 855,837 | ' |
Issuance of preferred stock and warrants pursuant to Regulation D, shares | ' | 13,283,324 | ' | ' | ' |
Issuance of stock for services, shares | ' | ' | 776,250 | ' | ' |
Employee compensation from stock options | 3,759,650 | ' | ' | 3,759,650 | ' |
Preferred stock/Debt conversions into common stock | ' | -7,893 | 7,893 | ' | ' |
Preferred stock/Debt conversions into common stock, shares | ' | -7,893,326 | 7,893,326 | ' | ' |
Net loss | -18,552,102 | ' | ' | ' | -18,552,102 |
Ending Balance at Dec. 31, 2010 | 10,699,573 | 5,390 | 91,298 | 96,952,908 | -86,350,023 |
Ending Balance, shares at Dec. 31, 2010 | ' | 5,389,998 | 91,297,883 | ' | ' |
Issuance of warrants for services | 945,116 | ' | ' | 945,116 | ' |
Exercise of warrants and stock options | 6,623,311 | ' | 7,185 | 6,616,126 | ' |
Exercise of warrants and stock options, shares | ' | ' | 7,185,522 | ' | ' |
Issuance of common stock and warrants pursuant to Regulation D | 7,041,239 | ' | 9,905 | 7,031,334 | ' |
Sale of non-controlling interest in Pure-ific Corporation and warrants | 443,500 | ' | ' | 443,500 | ' |
Issuance of common stock and warrants pursuant to Regulation D, shares | ' | ' | 9,905,062 | ' | ' |
Issuance of stock for services | 332,750 | ' | 350 | 332,400 | ' |
Issuance of stock for services, shares | ' | ' | 350,000 | ' | ' |
Employee compensation from stock options | 3,368,950 | ' | ' | 3,368,950 | ' |
Preferred stock/Debt conversions into common stock | ' | -1,859 | 1,859 | ' | ' |
Preferred stock/Debt conversions into common stock, shares | ' | -1,858,333 | 1,858,331 | ' | ' |
Net loss | -19,434,699 | ' | ' | ' | -19,434,699 |
Ending Balance at Dec. 31, 2011 | 10,019,740 | 3,531 | 110,597 | 115,690,334 | -105,784,722 |
Ending Balance, shares at Dec. 31, 2011 | ' | 3,531,665 | 110,596,798 | ' | ' |
Issuance of warrants for services | 1,512,026 | ' | ' | 1,512,026 | ' |
Issuance of common stock and warrants pursuant to Regulation D | 4,790,544 | ' | 6,228 | 4,784,316 | ' |
Issuance of common stock and warrants pursuant to Regulation D, shares | ' | ' | 6,227,647 | ' | ' |
Issuance of stock for services | 456,500 | ' | 550 | 455,950 | ' |
Issuance of stock for services, shares | ' | ' | 550,000 | ' | ' |
Employee compensation from stock options | 183,028 | ' | ' | 183,028 | ' |
Preferred stock/Debt conversions into common stock | ' | -1,053 | 1,053 | ' | ' |
Preferred stock/Debt conversions into common stock, shares | ' | -1,053,480 | 1,053,480 | ' | ' |
Net loss | -12,568,354 | ' | ' | ' | -12,568,354 |
Ending Balance at Dec. 31, 2012 | 4,393,484 | 2,478 | 118,428 | 122,625,654 | -118,353,076 |
Ending Balance, shares at Dec. 31, 2012 | ' | 2,478,185 | 118,427,925 | ' | ' |
Issuance of warrants for services | 1,527,518 | ' | ' | 1,527,518 | ' |
Exercise of warrants and stock options | 21,000 | ' | 44 | 20,956 | ' |
Exercise of warrants and stock options, shares | ' | ' | 43,750 | ' | ' |
Issuance of common stock and warrants pursuant to Regulation D | 12,204,174 | ' | 18,854 | 12,185,320 | ' |
Issuance of common stock and warrants pursuant to Regulation D, shares | ' | ' | 18,854,470 | ' | ' |
Issuance of preferred stock and warrants pursuant to Regulation D | 1,252,050 | 3,400 | ' | 1,248,650 | ' |
Issuance of stock for services | 149,500 | ' | 475 | 311,525 | ' |
Issuance of preferred stock and warrants pursuant to Regulation D, shares | ' | 3,400,001 | ' | ' | ' |
Issuance of stock for services, shares | ' | ' | 475,000 | ' | ' |
Employee compensation from stock options | 142,310 | ' | ' | 142,310 | ' |
Dividends on preferred stock | -29,063 | ' | ' | -29,063 | ' |
Preferred stock/Debt conversions into common stock | -29,063 | -2,173 | 2,173 | -29,063 | ' |
Preferred stock/Debt conversions into common stock, shares | ' | -2,173,186 | 2,173,186 | ' | ' |
Net loss | -11,100,250 | ' | ' | ' | -11,100,250 |
Ending Balance at Sep. 30, 2013 | $8,723,223 | $3,705 | $139,974 | $138,032,870 | ($129,453,326) |
Ending Balance, shares at Sep. 30, 2013 | ' | 3,705,000 | 139,974,331 | ' | ' |