Common Stocks - 98.3% |
| | Shares | Value ($) |
Biotechnology - 18.8% | | | |
Biotechnology - 18.8% | | | |
ADC Therapeutics SA (a) | | 118,600 | 1,742,234 |
Agios Pharmaceuticals, Inc. (a)(b) | | 100,000 | 2,911,000 |
Alnylam Pharmaceuticals, Inc. (a) | | 93,500 | 15,267,615 |
Ambrx Biopharma, Inc. ADR | | 47,100 | 194,052 |
Arcutis Biotherapeutics, Inc. (a) | | 88,500 | 1,704,510 |
Argenx SE ADR (a) | | 105,000 | 33,107,550 |
Ascendis Pharma A/S sponsored ADR (a) | | 110,474 | 12,965,229 |
Atara Biotherapeutics, Inc. (a) | | 230,000 | 2,136,700 |
Avid Bioservices, Inc. (a) | | 120,000 | 2,444,400 |
Beam Therapeutics, Inc. (a)(b) | | 56,000 | 3,208,800 |
BeiGene Ltd. ADR (a) | | 15,000 | 2,829,000 |
BioNTech SE ADR (a) | | 38,000 | 6,481,280 |
Blueprint Medicines Corp. (a) | | 69,000 | 4,407,720 |
Celldex Therapeutics, Inc. (a) | | 89,100 | 3,034,746 |
Century Therapeutics, Inc. | | 118,000 | 1,485,620 |
Cerevel Therapeutics Holdings (a) | | 173,887 | 6,087,784 |
Cytokinetics, Inc. (a) | | 196,630 | 7,237,950 |
Denali Therapeutics, Inc. (a) | | 90,000 | 2,895,300 |
Erasca, Inc. | | 340,000 | 2,924,000 |
Exelixis, Inc. (a) | | 228,000 | 5,168,760 |
Fate Therapeutics, Inc. (a)(b) | | 50,000 | 1,938,500 |
Forma Therapeutics Holdings, Inc. (a) | | 49,230 | 457,839 |
Generation Bio Co. (a)(b) | | 62,500 | 458,750 |
Graphite Bio, Inc. | | 100,000 | 510,000 |
Imago BioSciences, Inc. | | 50,000 | 963,500 |
Innovent Biologics, Inc. (a)(c) | | 1,080,000 | 3,634,344 |
Instil Bio, Inc. (a) | | 190,000 | 2,042,500 |
Intellia Therapeutics, Inc. (a) | | 70,000 | 5,086,900 |
Janux Therapeutics, Inc. | | 80,000 | 1,147,200 |
Keros Therapeutics, Inc. (a) | | 60,000 | 3,262,800 |
Kymera Therapeutics, Inc. (a) | | 54,000 | 2,285,280 |
Legend Biotech Corp. ADR (a) | | 30,000 | 1,090,200 |
Mirati Therapeutics, Inc. (a) | | 45,000 | 3,699,900 |
Morphic Holding, Inc. (a) | | 43,400 | 1,742,510 |
Nuvalent, Inc. Class A (a)(b) | | 55,067 | 764,881 |
Poseida Therapeutics, Inc. (a) | | 198,287 | 888,326 |
Prelude Therapeutics, Inc. (a) | | 101,308 | 699,025 |
PTC Therapeutics, Inc. (a) | | 145,000 | 5,409,950 |
Regeneron Pharmaceuticals, Inc. (a) | | 44,000 | 30,730,480 |
Relay Therapeutics, Inc. (a) | | 199,100 | 5,959,063 |
Repare Therapeutics, Inc. (a) | | 56,500 | 804,560 |
Revolution Medicines, Inc. (a)(b) | | 118,000 | 3,010,180 |
Sarepta Therapeutics, Inc. (a) | | 55,000 | 4,296,600 |
Scholar Rock Holding Corp. (a) | | 24,795 | 319,608 |
Shattuck Labs, Inc. (a) | | 36,553 | 155,716 |
Stoke Therapeutics, Inc. (a) | | 60,000 | 1,263,000 |
TG Therapeutics, Inc. (a) | | 400,000 | 3,804,000 |
Twist Bioscience Corp. (a) | | 80,000 | 3,950,400 |
uniQure B.V. (a) | | 90,000 | 1,626,300 |
Vaxcyte, Inc. (a) | | 114,500 | 2,765,175 |
Vertex Pharmaceuticals, Inc. (a) | | 38,000 | 9,916,860 |
Verve Therapeutics, Inc. | | 34,000 | 775,880 |
Xencor, Inc. (a)(b) | | 180,000 | 4,802,400 |
Xenon Pharmaceuticals, Inc. (a) | | 49,700 | 1,519,329 |
Zai Lab Ltd. (a) | | 769,150 | 3,501,683 |
Zentalis Pharmaceuticals, Inc. (a) | | 164,000 | 7,566,960 |
| | | 241,084,849 |
Health Care Equipment & Supplies - 17.9% | | | |
Health Care Equipment - 17.9% | | | |
Boston Scientific Corp. (a) | | 1,640,000 | 72,635,600 |
DexCom, Inc. (a) | | 12,800 | 6,548,480 |
Envista Holdings Corp. (a) | | 300,000 | 14,613,000 |
Hologic, Inc. (a) | | 85,000 | 6,529,700 |
Insulet Corp. (a) | | 134,728 | 35,890,192 |
Intuitive Surgical, Inc. (a) | | 18,800 | 5,671,584 |
Masimo Corp. (a) | | 56,000 | 8,150,240 |
Novocure Ltd. (a) | | 35,000 | 2,899,750 |
Outset Medical, Inc. (a) | | 140,000 | 6,356,000 |
Penumbra, Inc. (a) | | 173,409 | 38,519,341 |
PROCEPT BioRobotics Corp. (b) | | 71,482 | 2,501,155 |
ResMed, Inc. | | 69,000 | 16,733,190 |
Tandem Diabetes Care, Inc. (a) | | 100,000 | 11,629,000 |
| | | 228,677,232 |
Health Care Providers & Services - 27.3% | | | |
Health Care Facilities - 2.6% | | | |
Cano Health, Inc. (a)(b) | | 800,000 | 5,080,000 |
HCA Holdings, Inc. | | 22,800 | 5,714,136 |
Rede D'Oregon Sao Luiz SA (c) | | 690,000 | 7,231,808 |
Surgery Partners, Inc. (a) | | 228,000 | 12,551,400 |
The Oncology Institute, Inc. (d) | | 282,701 | 2,015,658 |
| | | 32,593,002 |
Health Care Services - 6.5% | | | |
1Life Healthcare, Inc. (a)(b) | | 220,000 | 2,437,600 |
agilon health, Inc. (a)(b) | | 630,000 | 15,970,500 |
Cigna Corp. | | 145,000 | 34,743,450 |
Guardant Health, Inc. (a) | | 64,000 | 4,239,360 |
LifeStance Health Group, Inc. | | 545,888 | 5,518,928 |
Oak Street Health, Inc. (a)(b) | | 760,000 | 20,428,800 |
| | | 83,338,638 |
Managed Health Care - 18.2% | | | |
Alignment Healthcare, Inc. (a) | | 460,000 | 5,165,800 |
Centene Corp. (a) | | 385,000 | 32,413,150 |
Humana, Inc. | | 136,000 | 59,183,120 |
UnitedHealth Group, Inc. | | 267,000 | 136,161,989 |
| | | 232,924,059 |
TOTAL HEALTH CARE PROVIDERS & SERVICES | | | 348,855,699 |
Health Care Technology - 2.3% | | | |
Health Care Technology - 2.3% | | | |
Change Healthcare, Inc. (a) | | 280,000 | 6,104,000 |
Definitive Healthcare Corp. | | 65,000 | 1,602,250 |
Doximity, Inc. (b) | | 100,000 | 5,209,000 |
Health Catalyst, Inc. (a) | | 29,244 | 764,146 |
Inspire Medical Systems, Inc. (a) | | 52,000 | 13,347,880 |
Medlive Technology Co. Ltd. (c) | | 500,000 | 499,031 |
Phreesia, Inc. (a) | | 90,000 | 2,372,400 |
| | | 29,898,707 |
Life Sciences Tools & Services - 18.8% | | | |
Life Sciences Tools & Services - 18.8% | | | |
10X Genomics, Inc. (a)(b) | | 60,000 | 4,564,200 |
Agilent Technologies, Inc. | | 70,000 | 9,263,100 |
Avantor, Inc. (a) | | 260,000 | 8,793,200 |
Bio-Rad Laboratories, Inc. Class A (a) | | 19,400 | 10,926,662 |
Bruker Corp. | | 218,000 | 14,017,400 |
Charles River Laboratories International, Inc. (a) | | 50,000 | 14,198,500 |
Danaher Corp. | | 250,000 | 73,332,500 |
Lonza Group AG | | 22,800 | 16,585,856 |
Maravai LifeSciences Holdings, Inc. (a) | | 189,900 | 6,697,773 |
Olink Holding AB ADR (a)(b) | | 160,000 | 2,825,600 |
Sartorius Stedim Biotech | | 10,841 | 4,467,339 |
Seer, Inc. (a) | | 67,127 | 1,023,015 |
Stevanato Group SpA | | 169,000 | 3,400,280 |
Thermo Fisher Scientific, Inc. | | 95,000 | 56,111,750 |
West Pharmaceutical Services, Inc. | | 36,000 | 14,785,560 |
| | | 240,992,735 |
Personal Products - 0.5% | | | |
Personal Products - 0.5% | | | |
The Beauty Health Co. (a)(b) | | 141,000 | 2,380,080 |
The Beauty Health Co. (d) | | 200,000 | 3,376,000 |
| | | 5,756,080 |
Pharmaceuticals - 12.3% | | | |
Pharmaceuticals - 12.3% | | | |
Arvinas Holding Co. LLC (a) | | 105,000 | 7,066,500 |
AstraZeneca PLC (United Kingdom) | | 146,000 | 19,361,505 |
Bristol-Myers Squibb Co. | | 280,000 | 20,448,400 |
Eli Lilly & Co. | | 218,000 | 62,428,660 |
Pharvaris BV (a) | | 80,000 | 1,496,000 |
Pliant Therapeutics, Inc. (a) | | 74,764 | 524,096 |
Roche Holding AG (participation certificate) | | 50,000 | 19,783,093 |
Royalty Pharma PLC | | 580,000 | 22,596,800 |
Theseus Pharmaceuticals, Inc. | | 80,000 | 922,400 |
UCB SA | | 28,000 | 3,359,239 |
| | | 157,986,693 |
Specialty Retail - 0.4% | | | |
Specialty Stores - 0.4% | | | |
Warby Parker, Inc. (a)(b) | | 152,000 | 5,139,120 |
TOTAL COMMON STOCKS (Cost $890,325,412) | | | 1,258,391,115 |
| | | |
Fiscal year to date information regarding the Fund's investments in Fidelity Central Funds, including the ownership percentage, is presented below.
Amounts in the income column in the above table include any capital gain distributions from underlying funds.
Amount for Fidelity Securities Lending Cash Central Fund represents the income earned on investing cash collateral, less rebates paid to borrowers and any lending agent fees associated with the loan, plus any premium payments received for lending certain types of securities.
Investments are valued as of 4:00 p.m. Eastern time on the last calendar day of the period. Securities transactions are accounted for as of trade date. The Board of Trustees (the Board) has delegated the day to day responsibility for the valuation of the Fund's investments to the Fair Value Committee (the Committee) established by the Fund's investment adviser. In accordance with valuation policies and procedures approved by the Board, the Fund attempts to obtain prices from one or more third party pricing vendors or brokers to value its investments. When current market prices, quotations or currency exchange rates are not readily available or reliable, investments will be fair valued in good faith by the Committee, in accordance with procedures adopted by the Board. Factors used in determining fair value vary by investment type and may include market or investment specific events. The frequency with which these procedures are used cannot be predicted and they may be utilized to a significant extent. The Committee oversees the Fund's valuation policies and procedures and reports to the Board on the Committee's activities and fair value determinations. The Board monitors the appropriateness of the procedures used in valuing the Fund's investments and ratifies the fair value determinations of the Committee.
The inputs to valuation techniques used to value investments are categorized into a disclosure hierarchy consisting of three levels as shown below:
Level 2 - other significant observable inputs (including quoted prices for similar investments, interest rates, prepayment speeds, etc.)
Level 3 - unobservable inputs (including the Fund's own assumptions based on the best information available)
Investments in any open-end mutual funds are valued at their closing net asset value (NAV) each business day and are categorized as Level 1 in the hierarchy.
Changes in valuation techniques may result in transfers in or out of an assigned level within the disclosure hierarchy.
For additional information on the Fund's significant accounting policies, please refer to the Fund's most recent semiannual or annual shareholder report.
The fund's schedule of investments as of the date on the cover of this report has not been audited. This report is provided for the general information of the fund's shareholders. For more information regarding the fund and its holdings, please see the fund's most recent prospectus and annual report.
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