Consolidated Statements of Stockholders' (Deficit) Equity (USD $) | Total | Preferred Stock [Member] | Common Stock [Member] | Additional Paid-In Capital [Member] | Deferred Compensation [Member] | Accumulated Other Comprehensive Income (Loss) [Member] | Deficit Accumulated During Development Stage [Member] |
Beginning Balance at Oct. 16, 1992 | ' | ' | ' | ' | ' | ' | ' |
Beginning Balance, Shares at Oct. 16, 1992 | ' | ' | ' | ' | ' | ' | ' |
Issuance of common stock | 48,725 | ' | 3,040 | 45,685 | ' | ' | ' |
Issuance of common stock, shares | ' | ' | 304,009 | ' | ' | ' | ' |
Exercise of warrants and stock options | 7,596,439 | ' | 11,850 | 7,584,589 | ' | ' | ' |
Exercise of warrants and stock options, shares | ' | ' | 1,185,039 | ' | ' | ' | ' |
Issuance of common stock and warrants, net of issuance costs | 56,458,546 | ' | 115,168 | 56,343,378 | ' | ' | ' |
Issuance of common stock and warrants, net of issuance costs, shares | ' | ' | 11,516,790 | ' | ' | ' | ' |
Issuance of common stock and warrants upon Merger | 14,603,948 | ' | 7,239 | 14,596,709 | ' | ' | ' |
Issuance of common stock and warrants upon Merger, shares | ' | ' | 723,947 | ' | ' | ' | ' |
Conversion of convertible debentures | 988,591 | ' | 313 | 988,278 | ' | ' | ' |
Conversion of convertible debentures, shares | ' | ' | 31,321 | ' | ' | ' | ' |
Issuance of warrants related to debentures, net of issuance costs | 3,632,632 | ' | ' | 3,632,632 | ' | ' | ' |
Issuance of warrants related to preferred series C stock and BCF, net of issuance costs | 3,736,789 | ' | ' | 3,736,789 | ' | ' | ' |
Preferred stock, net of issuance costs | 25,584,456 | 2,296,355 | ' | 23,288,101 | ' | ' | ' |
Preferred stock, net of issuance costs, shares | ' | 240,711 | ' | ' | ' | ' | ' |
Conversion of Preferred Stock K and payment of interest, net of issuance costs | 6,179,186 | -1,491,474 | 15,538 | 7,655,122 | ' | ' | ' |
Accretion of preferred stock | -4,327,679 | ' | ' | -4,327,679 | ' | ' | ' |
Conversion of Preferred Stock K and payment of interest, net of issuance costs, shares | ' | -240,149.70 | 1,553,749 | ' | ' | ' | ' |
Conversion of debentures and payment of interest, net of issuance costs | 4,847,420 | ' | 3,171 | 4,844,249 | ' | ' | ' |
Conversion of debentures and payment of interest, net of issuance costs, shares | ' | ' | 317,083 | ' | ' | ' | ' |
Conversion of preferred stock and modification of warrants | ' | -3,501,539 | 9,006 | 3,492,533 | ' | ' | ' |
Conversion of preferred stock and modification of warrants, shares | ' | -561.3 | 900,646 | ' | ' | ' | ' |
Preferred stock conversion inducement | -600,564 | ' | ' | -600,564 | ' | ' | ' |
Amortization of preferred stock Series E BCF | ' | 2,696,658 | ' | -2,696,658 | ' | ' | ' |
Issuance of warrants related to Series E Stock, net of issuance costs | 2,049,297 | ' | ' | 2,049,297 | ' | ' | ' |
Issuance of common stock and cancellation of warrants | ' | ' | 427 | -427 | ' | ' | ' |
Issuance of common stock and cancellation of warrants, shares | ' | ' | 42,667 | ' | ' | ' | ' |
Dividend accrual preferred Series E | -573,597 | ' | ' | -573,597 | ' | ' | ' |
BCF on convertible notes payable | 558,000 | ' | ' | 558,000 | ' | ' | ' |
Deferred compensation- stock options and warrants | ' | ' | ' | 804,607 | -804,607 | ' | ' |
Share-based compensation | 4,274,806 | ' | ' | 3,470,199 | 804,607 | ' | ' |
Modification of options and warrants | 1,804,694 | ' | ' | 1,804,694 | ' | ' | ' |
Other | 69,933 | ' | 8 | 69,925 | ' | ' | ' |
Other, shares | ' | ' | 783 | ' | ' | ' | ' |
Net income (loss) | -143,503,529 | ' | ' | ' | ' | ' | -143,503,529 |
Ending Balance at Dec. 31, 2006 | ' | ' | ' | ' | ' | ' | ' |
Exercise of warrants and stock options | 145,705 | ' | 2,022 | 143,683 | ' | ' | ' |
Exercise of warrants and stock options, shares | ' | ' | 202,183 | ' | ' | ' | ' |
Conversion of convertible debentures | 10,000,000 | ' | 40,000 | 9,960,000 | ' | ' | ' |
Conversion of convertible debentures, shares | ' | ' | 4,000,000 | ' | ' | ' | ' |
BCF on convertible notes payable | 1,880,000 | ' | ' | 1,880,000 | ' | ' | ' |
Share-based compensation | 1,665,155 | ' | ' | 1,665,155 | ' | ' | ' |
Modification of options and warrants | 5,614 | ' | ' | 5,614 | ' | ' | ' |
Net income (loss) | -19,548,348 | ' | ' | ' | ' | ' | -19,548,348 |
Net Unrealized gain (loss) on marketable securities | 9,310 | ' | ' | ' | ' | 9,310 | ' |
Ending Balance at Dec. 31, 2007 | -22,414,471 | ' | 207,782 | 140,420,314 | ' | 9,310 | -163,051,877 |
Ending Balance, shares at Dec. 31, 2007 | ' | ' | 20,778,217 | ' | ' | ' | ' |
Issuance of common stock | 1,085,275 | ' | 5,718 | 1,079,557 | ' | ' | ' |
Issuance of common stock, shares | ' | ' | 571,806 | ' | ' | ' | ' |
Exercise of warrants and stock options | 2,541 | ' | 11 | 2,530 | ' | ' | ' |
Exercise of warrants and stock options, shares | ' | ' | 1,100 | ' | ' | ' | ' |
Conversion of convertible debentures | 120,000 | ' | 480 | 119,520 | ' | ' | ' |
Conversion of convertible debentures, shares | ' | ' | 48,000 | ' | ' | ' | ' |
BCF on convertible notes payable | 380,000 | ' | ' | 380,000 | ' | ' | ' |
Share-based compensation | 1,670,063 | ' | ' | 1,670,063 | ' | ' | ' |
Net income (loss) | -20,847,459 | ' | ' | ' | ' | ' | -20,847,459 |
Net Unrealized gain (loss) on marketable securities | -9,310 | ' | ' | ' | ' | -9,310 | ' |
Ending Balance at Dec. 31, 2008 | -40,013,361 | ' | 213,991 | 143,671,984 | ' | ' | -183,899,336 |
Ending Balance, shares at Dec. 31, 2008 | ' | ' | 21,399,123 | ' | ' | ' | ' |
Issuance of common stock | 2,002,000 | ' | 41,565 | 1,960,435 | ' | ' | ' |
Issuance of common stock, shares | ' | ' | 4,156,522 | ' | ' | ' | ' |
Accretion of convertible redeemable preferred stock | -194,107 | ' | ' | -192,107 | ' | ' | -2,000 |
Share-based compensation | 1,473,083 | ' | ' | 1,473,083 | ' | ' | ' |
Net income (loss) | -10,776,937 | ' | ' | ' | ' | ' | -10,776,937 |
Ending Balance at Dec. 31, 2009 | -47,509,322 | ' | 255,556 | 146,913,395 | ' | ' | -194,678,273 |
Ending Balance, shares at Dec. 31, 2009 | ' | ' | 25,555,645 | ' | ' | ' | ' |
Issuance of common stock | 0 | ' | 15,000 | -15,000 | ' | ' | ' |
Issuance of common stock, shares | ' | ' | 1,500,000 | ' | ' | ' | ' |
Accretion of preferred stock | -343,000 | ' | ' | -343,000 | ' | ' | ' |
Share-based compensation | 61,722 | ' | ' | 61,722 | ' | ' | ' |
Buyback of common stock | -8,100 | ' | -2,700 | -5,400 | ' | ' | ' |
Buyback of common stock, shares | ' | ' | -270,000 | ' | ' | ' | ' |
Net income (loss) | 512,419 | ' | ' | ' | ' | ' | 512,419 |
Ending Balance at Dec. 31, 2010 | -47,286,281 | ' | 267,856 | 146,611,717 | ' | ' | -194,165,854 |
Ending Balance, shares at Dec. 31, 2010 | ' | ' | 26,785,645 | ' | ' | ' | ' |
Conversion of convertible debentures | 7,172,412 | ' | 28,690 | 7,143,722 | ' | ' | ' |
Conversion of convertible debentures, shares | ' | ' | 2,868,965 | ' | ' | ' | ' |
Accretion of preferred stock | 486,663 | ' | ' | 486,663 | ' | ' | ' |
Issuance of common stock-debt forgiveness | 28,680 | ' | 3,585 | 25,095 | ' | ' | ' |
Issuance of common stock-debt forgiveness, shares | ' | ' | 358,500 | ' | ' | ' | ' |
Share-based compensation | 834 | ' | ' | 834 | ' | ' | ' |
Buyback of common stock per share | -7,172 | ' | -28,690 | 21,518 | ' | ' | ' |
Buyback of common stock per share, shares | ' | ' | -2,868,965 | ' | ' | ' | ' |
Buyback of common stock | -11,084 | ' | -11,084 | ' | ' | ' | ' |
Buyback of common stock, shares | ' | ' | -1,108,425 | ' | ' | ' | ' |
Forgiveness of accrued interest on convertible debt | 6,132,499 | ' | ' | 6,132,499 | ' | ' | ' |
Conversion of Series F Preferred to common stock | ' | ' | 46,000 | 4,554,000 | ' | ' | ' |
Conversion of Series F Preferred to common stock, shares | ' | ' | 4,600,000 | ' | ' | ' | ' |
Forgiveness of accrued interest on note payable | 195,807 | ' | ' | 195,807 | ' | ' | ' |
Settlement of note payable | 999,000 | ' | ' | 999,000 | ' | ' | ' |
Net income (loss) | -2,882,214 | ' | ' | ' | ' | ' | -2,882,214 |
Net Unrealized gain (loss) on marketable securities | -31,367 | ' | ' | ' | ' | -31,367 | ' |
Ending Balance at Dec. 31, 2011 | -30,602,223 | ' | 306,357 | 166,170,855 | ' | -31,367 | -197,048,068 |
Ending Balance, shares at Dec. 31, 2011 | ' | ' | 30,635,720 | ' | ' | ' | ' |
Conversion of convertible debentures | 5,827,588 | ' | 23,311 | 5,804,277 | ' | ' | ' |
Conversion of convertible debentures, shares | ' | ' | 2,331,035 | ' | ' | ' | ' |
Accretion of preferred stock | -21,057 | ' | ' | -21,057 | ' | ' | ' |
Buyback of common stock per share | -1,866 | ' | -23,311 | 21,445 | ' | ' | ' |
Buyback of common stock per share, shares | ' | ' | -2,331,035 | ' | ' | ' | ' |
Net income (loss) | -1,645,476 | ' | ' | ' | ' | ' | -1,645,476 |
Net Unrealized gain (loss) on marketable securities | -277,837 | ' | ' | ' | ' | -277,837 | ' |
Ending Balance at Dec. 31, 2012 | -26,720,871 | ' | 306,357 | 171,975,520 | ' | -309,204 | -198,693,544 |
Ending Balance, shares at Dec. 31, 2012 | ' | ' | 30,635,720 | ' | ' | ' | ' |
Net gain on debt modification | 682,670 | ' | ' | 682,670 | ' | ' | ' |
Accretion of preferred stock | -20,942 | ' | ' | -20,942 | ' | ' | ' |
Gain on release and sale of contingent royalty liability | 16,025,000 | ' | ' | 16,025,000 | ' | ' | ' |
Net income (loss) | -941,529 | ' | ' | ' | ' | ' | -941,529 |
Net Unrealized gain (loss) on marketable securities | 315,854 | ' | ' | ' | ' | 315,854 | ' |
Ending Balance at Dec. 31, 2013 | ($10,659,818) | ' | $306,357 | $188,662,248 | ' | $6,650 | ($199,635,073) |
Ending Balance, shares at Dec. 31, 2013 | ' | ' | 30,635,720 | ' | ' | ' | ' |