Mail Stop 7010

                                                November 3, 2005



Mr. Anthony J. Simonetta
Strategic Diagnostics Inc.
111 Pencader Drive
Newark, Deleware 19702

	RE:	Strategic Diagnostics Inc.
      Form 10-K for the year ended December 31, 2004
      Filed March 30, 2005
      File No. 000-22400


Dear Mr. Simonetta:

      Thank you for the additional information provided in your
response letter dated October 28, 2005 regarding the nature and
the
related accounting for costs associated with the animals used in
your
production of custom antibodies.  We also appreciate the
information
you provided to us with regard to your revenue recognition related
to
your sale of custom antibodies in our October 6, 2005 conference
call
and prior correspondence regarding this issue.  Based on this
information, we have the following additional comments for which
we
believe you should revise your financial statements.  If you
disagree,
we will consider your explanation as to why our comment is
inapplicable.

FORM 10-K FOR THE PERIOD ENDED DECEMBER 31, 2004

Based on the terms of your customer contracts, we believe that
revenue
related to your sale of custom antibodies should not be recognized
until delivery and customer acceptance pursuant to SAB Topic
13.A.1
and 13.A.3b.  In this regard, we note that revenues are considered
to
have been earned when an entity has substantially accomplished
what it
must do to be entitled to the benefits represented by the
revenues.
We note that you believe that percentage of completion accounting
is
the appropriate revenue recognition model for your for production
and
sale of custom antibodies because the related purchase contracts
are
binding, fixed price agreements based on a customer`s
specifications
and require a time period longer than 30 days but less than 12
months.
In addition, we note your belief that you have the ability to
estimate
the costs you incur to produce the custom antibodies.  However,
paragraph 22 of SOP 81-1 sets forth the recommended basis for
using
the percentage-of-completion method and the reasons for the
recommendation.  Under most contracts for production of goods, or
provision of related services to a buyer`s specifications certain
aspects of the contract indicate that percentage-of-completion may
be
appropriate. These aspects include the following:
- - Both the buyer and the seller have enforceable rights.
- - The buyer has the legal right to require specific performance of
the
contract such that the seller has, in effect, agreed to sell the
rights to work-in-progress as the work progresses.
- - The buyer is required to make progress payments to support his
ownership investment.
- - The buyer approves goods produced or services performed,
periodically, to determine if they meet the contract requirements.
- - The buyer has the right to take over the work-in-progress at his
option.

The above factors do not appear to be present in your arrangements
and
therefore these arrangements do not support the concept that in an
economic sense performance is, in effect, a continuous sale
(transfer
of ownership rights) that occurs as the work progresses.  As a
result,
it appears that your arrangements for the production of custom
antibodies do not fall within the scope of SOP 81-1.
*    *    *    *

      As appropriate, please respond to these comments within 10
business days or tell us when you will provide us with a response.
Please furnish a letter that keys your responses to our comments
and
provides any requested supplemental information.  Detailed
response
letters greatly facilitate our review.  Please file your response
letter on EDGAR.  Please understand that we may have additional
comments after reviewing your response to our comments.

     If you have any questions regarding these comments, please
direct
them to Patricia Armelin, Staff Accountant, at (202) 551-3747,
Jeanne
Baker at (202) 551-3691 or, in their absence, to the undersigned
at
(202) 551-3768.


            Sincerely,



                  John Cash
                  Accounting Branch Chief


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Mr. Anthony J. Simonetta
Strategic Diagnostics Inc.
November 3, 2005
Page 1



UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549-7010

         DIVISION OF
CORPORATION FINANCE