Via Facsimile and U.S. Mail
Mail Stop 6010


      December 1, 2005



Phillip K. Yachmetz
Senior Vice President - Corporate Strategy
& General Counsel
Savient Pharmaceuticals, Inc
One Tower Center, 14th Floor
East Brunswick, New Jersey 08816


Re:	Savient Pharmaceuticals, Inc.
	Form 10-K for Fiscal Year Ended December 31, 2004
	Filed March 31, 2005
	Form 10-Q for the quarter ended March 31, 2005
	Filed May 10, 2005
	File No. 000-15313


Dear Mr. Yachmetz:

      We have reviewed your November 8, 2005 letter and have the
following additional comments.  Where indicated, we think you
should
revise your documents as described below in response to these
comments.  If you disagree, we will consider your explanation as
to
why our comment is inapplicable or a revision is unnecessary.
Please
be as detailed as necessary in your explanation.  In some of our
comments, we may ask you to provide us with information so we may
better understand your disclosure.

	Please understand that the purpose of our review process is
to
assist you in your compliance with the applicable disclosure
requirements and to enhance the overall disclosure in your
filings.
We look forward to working with you in these respects.  We welcome
any questions you may have about our comments or on any other
aspect
of our review.  Feel free to call us at the telephone numbers
listed
at the end of this letter.




Form 10-K for the Fiscal Year Ended December 31, 2004

Item 7.  Management`s Discussion And Analysis Of Financial
Condition
And Results Of Operations, page 36

Critical Accounting Policies and the Use of Estimates, page 37

Revenue Recognition, page 38

1. Refer to your response to comment one.  We note that your
critical
accounting discussion related to sales returns and allowances is
based heavily in the literature and descriptions provided in that
literature, but it does not appear to include a lot of company
specific information.
* Please revise your disclosure to include a discussion that is
more
similar to what you provided in this response.
* Include the previously requested rollforward for each of the
types
of reserves, i.e. returns and rebates.
* Revise your inventory allowance discussion to include additional
discussion such as what you provided in your response.
* For all policies identified as critical, include some
sensitivity
analysis that reflects the impact that reasonably likely changes
could have on your financial position.

Note 2 - Acquisitions and Investments, page 67

(b) Acquisition of Myelos Corporation, page 69

2. Refer to your response to comment four.  Your reference to the
previous comment letter related to this issue does not appear to
contain sufficient support for the inclusion of this amount as
negative goodwill under the then current guidance of paragraph 91
of
APB 16.  The amount of the excess of fair value of the acquired
net
assets over cost (i.e. negative goodwill) should be allocated pro
rata to reduce non-current assets including the amount allocated
to
the charge related to your valuation of in-process research and
development. Please revise your financial statements to remove
this
negative goodwill for all periods presented.

General

3. Please provide a statement with the appropriate three separate
"Tandy" acknowledgements as requested in our initial letter dated
September 20, 2005.


*    *    *    *

      As appropriate, please amend your December 31, 2004 Form 10-
K
and subsequent Forms 10-Q to respond to these comments within 10
business days or tell us when you will provide us with a response.
You may wish to provide us with marked copies of the amendments to
expedite our review.  Please furnish a cover letter with your
amendments that keys your responses to our comments and provides
any
requested information.  Detailed cover letters greatly facilitate
our
review.  Please file your letter on EDGAR under the form type
label
CORRSEP.  Please understand that we may have additional comments
after reviewing your amendment and responses to our comments.

      You may contact Jim Peklenk, Staff Accountant, at (202) 551-
3661 or Jim Atkinson, Accounting Branch Chief, at (202) 551-3674
or
me, at (202) 551-3679, regarding any questions.

      Sincerely,



      Jim B. Rosenberg
Senior Assistant Chief Accountant
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Phillip K. Yachmetz
Savient Pharmaceuticals, Inc.
December 1, 2005
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