May 18, 2006

Mail Stop 6010


R. Scott Huennekens
Chief Executive Officer
Volcano Corporation
2870 Kilgore Road
Rancho Cordova, CA 95670

      Re:	Volcano Corporation
      Amendment No. 1 to Registration Statement on Form S-1
      Filed May 5, 2006
		File No. 333-132678

Dear Mr. Huennekens:

      We have reviewed your filing and have the following
comments.
Where indicated, we think you should revise your document in
response
to these comments.  If you disagree, we will consider your
explanation as to why our comment is inapplicable or a revision is
unnecessary.  Please be as detailed as necessary in your
explanation.
In some of our comments, we may ask you to provide us with
information so we may better understand your disclosure.  After
reviewing this information, we may raise additional comments.

      We welcome any questions you may have about our comments or
any
other aspect of our review.  Feel free to call us at the telephone
numbers listed at the end of this letter.

Amendment No. 1 to Form S-1

Management`s Discussion and Analysis of Financial Condition, page
43

- -Comparison of Three Months Ended March 31, 2006 and 2005, page 48

1. We note that your gross margin for 2005 was 47.9% while gross
margins for the first quarter of 2005 and 2006 were 56.5% and
58.6%,
respectively.  Tell us and revise your results of operations
section
to clarify why the first quarter margins are significantly higher
than your previous year-to-date gross margins.

Off-balance Sheet Arrangements and Other Contractual Obligations,
page 54

2. Revise your table of contractual obligations and commercial
commitments to provide the information as of the latest fiscal
year
end balance sheet date as required by Item 303(a)(5) of Regulation
S-
K.  If there have been significant changes to the amounts as of
the
end of the most recent interim period as compared to the end of
the
previous year, then you should disclose any material changes.  We
refer you to Section III.C of FRR-67.

Notes to Consolidated Financial Statements

Note 1. Summary of Significant Accounting Policies

- -Property and Equipment, page F-10

3. You state that the medical diagnostic equipment is "loaned" to
certain customers that purchase and use your single-procedure
disposable products.  It is unclear to us how such equipment is
loaned to some customers for free and sold to others who use your
single-procedure disposable products.  Please tell us the nature
of
the arrangements with these customers where the equipment is on
loan.
Consider clarifying your current disclosure as necessary.

- - Revenue Recognition, page F-12

4. We reissue our prior comment 33 in its entirety.

Note 9. Stockholders` Deficit, page F-29

5. We reissue our prior comment 34 in its entirety.





Note 14. Related Parties, page F-34

6. We refer you to prior comment 35.  We note that you have
revised
your disclosure in response to our prior comment; however, revise
your disclosures to clarify the following:

* Disclose the nature and terms of the distribution option
agreement
that was entered into in July 2003 similar to the information
contained in your response to prior comment 35.

* You state that you were granted the right to terminate the
distribution option agreement and "paid Medtronic $2 million."  It
appears from your response that the termination fee was waived.
Please clarify for the reader.

* Please clarify what you mean by "in order to maintain greater
flexibility in developing and executing its product sales
strategies
in Japan" the agreement was terminated.

* Disclose the nature and terms of the new 2006 agreement.

* Clarify that Medtronic waived its right to the termination fee
of
$2 million or, if true, you will supply product to them with a
fair
value of $2 million in lieu of paying in cash a termination fee of
$2
million.

* Clarify why the distribution of consoles in the first quarter of
2006 is under the terms of the 2006 agreement.


      As appropriate, please amend your registration statement in
response to these comments.  You may wish to provide us with
marked
copies of the amendment to expedite our review.  Please furnish a
cover letter with your amendment that keys your responses to our
comments and provides any requested information.  Detailed cover
letters greatly facilitate our review.  Please understand that we
may
have additional comments after reviewing your amendment and
responses
to our comments.

      We urge all persons who are responsible for the accuracy and
adequacy of the disclosure in the filing to be certain that the
filing includes all information required under the Securities Act
of
1933 and that they have provided all information investors require
for an informed investment decision.  Since the company and its
management are in possession of all facts relating to a company`s
disclosure, they are responsible for the accuracy and adequacy of
the
disclosures they have made.

      We will consider a written request for acceleration of the
effective date of the registration statement as confirmation of
the
fact that those requesting acceleration are aware of their
respective
responsibilities under the Securities Act of 1933 and the
Securities
Exchange Act of 1934 as they relate to the proposed public
offering
of the securities specified in the above registration statement.
We
will act on the request and, pursuant to delegated authority,
grant
acceleration of the effective date.

      We direct your attention to Rules 460 and 461 regarding
requesting acceleration of a registration statement.  Please allow
adequate time after the filing of any amendment for further review
before submitting a request for acceleration.  Please provide this
request at least two business days in advance of the requested
effective date.

      You may contact Thomas Dyer at (202) 551-3641 or Michele
Gohlke
at (202) 551-3327 if you have questions regarding comments on the
financial statements and related matters.  Please contact Eduardo
Aleman at (202) 551-3646 or me at (202) 551-3800 with any other
questions.


      					Sincerely,



      					Peggy Fisher
      Assistant Director


cc(via facsimile):  Dale S. Freeman

R. Scott Huennekens
Volcano Corporation
May 18, 2006
Page 1