September 26, 2018

Stuart Paul
Chief Executive Officer
Rockwell Medical, Inc.
30142 Wixom Road
Wixom, Michigan 48393

       Re: Rockwell Medical, Inc.
           Registration Statement on Form S-3
           Filed September 14, 2018
           File No. 333-227363

Dear Mr. Paul:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Tim Buchmiller at (20)2) 551-3635 with any questions.



                                                            Sincerely,

                                                            Division of
Corporation Finance
                                                            Office of
Electronics and Machinery
cc:    Steven R. Barth, Esq.