November 28, 2018

John Poss
Chief Executive Officer
GB Sciences, Inc.
3550 W. Teco Avenue
Las Vegas, NV 89118

       Re: GB Sciences, Inc.
           Amendment No. 1 to Registration Statement on Form S-1
           Filed November 21, 2018
           File No. 333-227452

Dear Mr. Poss:

      We have reviewed your amended registration statement and have the
following
comments. In some of our comments, we may ask you to provide us with
information so we
may better understand your disclosure.

        Please respond to this letter by amending your registration statement
and providing the
requested information. If you do not believe our comments apply to your facts
and
circumstances or do not believe an amendment is appropriate, please tell us why
in your
response.

        After reviewing any amendment to your registration statement and the
information you
provide in response to these comments, we may have additional comments. Unless
we note
otherwise, our references to prior comments are to comments in our October 10,
2018 letter.

Form S-1/A filed November 21, 2018

Description of Warrants Related to Shares Being Registered, page 18

1.     We note the revised disclosure on pages 18 to 19 you have included in
response to
       comment 4. With respect to Warrants B, D and E, please describe the
material terms of
       the transactions in which you issued the warrants.
2.     You state in response to comment 5 that you "have issued additional
warrants for the
       purchase of 10,000,000 shares" and are registering the common shares
underlying these
       warrants. Please tell us when such additional warrants were issued to
the selling
       stockholders and describe the material terms of such warrants and the
transactions in
       which you issued them. If applicable, please also revise the disclosure
on page 92 to
       provide all information that Item 701 of Regulation S-K requires.
 John Poss
GB Sciences, Inc.
November 28, 2018
Page 2
Notes to Condensed Consolidated Financial Statements (Unaudited)
Note 10 - Subsequent Events
Termination of Agreements with THC LLC, page 66

3.       You state here that you terminated all agreements with THC LLC in
October 2018.
         Please update the disclosure regarding these agreements on page 21 and
pages 29 to 30 to
         reflect their termination.
       Please contact Parhaum J. Hamidi, Attorney-Adviser, at (202) 551-3421 or
Karina V.
Dorin, Attorney-Adviser, at (202) 551-3763 with any questions.



FirstName LastNameJohn Poss                                  Sincerely,
Comapany NameGB Sciences, Inc.
                                                             Division of
Corporation Finance
November 28, 2018 Page 2                                     Office of Natural
Resources
FirstName LastName