January 31, 2019

Garry Menzel
Chief Executive Officer
TCR2 Therapeutics Inc.
100 Binney Street
Suite 710
Cambridge, MA 02142

       Re: TCR2 Therapeutics Inc.
           Registration Statement on Form S-1
           Filed December 28, 2018
           File No. 333-229066

Dear Mr. Menzel:

       We have reviewed your registration statement and have the following
comments. In
some of our comments, we may ask you to provide us with information so we may
better
understand your disclosure.

       Please respond to this letter by amending your registration statement
and providing the
requested information. If you do not believe our comments apply to your facts
and
circumstances or do not believe an amendment is appropriate, please tell us why
in your
response.

       After reviewing any amendment to your registration statement and the
information you
provide in response to these comments, we may have additional comments.

Registration Statement on Form S-1

Capitalization, page 73

1.     Your capitalization table indicates that there are 5,626,474 shares of
common stock
       outstanding as of September 30, 2018; however, your Balance Sheets (page
F-21) and
       Statements of Equity (page F-23) indicate that there are 4,218,071
shares of common
       stock outstanding as of September 30, 2018. Please clarify throughout
the filing, as
       applicable, if you issued and repurchased common stock as of September
30, 2018 in
       connection with the 1,408,399 shares of unvested common stock options,
unvested
       warrants and restricted stock discussed on pages 10 and 74. Please
explain why these
       issuances are excluded from common stock outstanding on the balance
sheet.
 Garry Menzel
TCR2 Therapeutics Inc.
January 31, 2019
Page 2
2.       Your calculation of 112,626,475 shares of common stock outstanding as
of September 30,
         2018 after giving effect to the automatic conversion appears to be
based on 5,626,474
         shares outstanding. Please revise throughout the filing or advise.
Dilution, page 75

3.       It appears that your net tangible book value, both historical and pro
forma, at September
         30, 2018 includes deferred offering costs of $1.2 million. Please
revise to calculate net
         tangible book value excluding deferred offering costs. Refer to Item
506 of Regulation S-
         K.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

       You may contact Sisi Cheng at 202-551-5004 or Mary Mast at 202-551-3613
if you have
questions regarding comments on the financial statements and related matters.
Please contact
Donald Field at 202-551-3680 or Dietrich King at 202-551-8071 with any other
questions.



FirstName LastNameGarry Menzel                               Sincerely,
Comapany NameTCR2 Therapeutics Inc.
                                                             Division of
Corporation Finance
January 31, 2019 Page 2                                      Office of
Healthcare & Insurance
FirstName LastName