June 7, 2019


Via E-Mail

Lawrence Remmel
Pryor Cashman LLP
7 Times Square
New York, NY 10036

       Re:    Adhera Therapeutics, Inc.
              Schedule TO-I filed on May 28, 2019
              Schedule TO-I/A filed June 6, 2019
              File No. 5-36676

Dear Mr. Remmel:

        The Office of Mergers and Acquisitions has conducted a limited review
of the filing
listed above. Our review was limited to the issues identified in our comments
below. All
defined terms have the same meaning as in the Offer to Exchange included as
Exhibit
99(a)(1)(A) to the Schedule TO-I filed on May 28, 2019.

       Please respond to this letter by revising your filing, by providing the
requested
information, or by advising us when you will provide the requested response. If
you do not
believe our comments apply to your facts and circumstances or do not believe an
amendment is
appropriate, please tell us why in your response.

       After reviewing any amendment to your filing and the information you
provide in
response to these comments, we may have additional comments.

Schedule TO-I filed May 28, 2019

Item 10. Financial Statements; Offer to Exchange- Financial Information
Regarding the
Company, page 11

   1. While you may incorporate by reference the financial statements required
by Item
      1010(a) and (b) of Regulation M-A, the summarized financial information
specified by
      Item 1010(c) must be included in the Offer to Purchase. See Instruction 6
to Item 10 of
      Schedule TO and Question 7, Section I.H in the July 2001 (Third
Supplement) to the
      Division of Corporation Finance's Publicly Available Telephone
Interpretations available
 Lawrence Remmel, Esq.
Pryor Cashman, LLP
June 7, 2019
Page 2



       on our Web site at www.sec.gov. Please revise to include summary
financial information
       in the Offer to Purchase.

   2. In your response letter, explain how you reached the determination that
pro forma
      financial information pursuant to Item 1010(b) of Regulation M-A was not
required in
      the context of this exchange offer. We note that the Offer is conditioned
on participation
      in the Financing Transaction and the completion of the Reverse Stock
Split, and the
      Shares issuable upon exchange of the Warrants pursuant to the Offer will
represent 84%
      of the Company's outstanding Shares as of May 24, 2019. Alternatively,
include the pro
      forma information in a revised filing.

   3. See our comments above. This revised disclosure must be disseminated to
shareholders
      in the same manner as the original Offer to Purchase. Please confirm your
understanding
      in your response letter.

Exhibit 99(A)(1)(A)   Offer to Exchange

General

   4. You state that the Shares to be exchanged in the Offer have not been
registered and are
      being issued pursuant to Rule 506(b) of Regulation D. Pursuant to Rule
13e-4(f)(8)(i),
      the Offer must be open to all holders of the subject securities. In your
response letter,
      describe the facts supporting your reliance on this exemption, including
how you will
      ascertain whether the warrant holders to whom the Offer is made qualify
to receive
      Shares pursuant to this exemption from the registration requirements of
the Securities Act
      of 1933.

   5. See our last comment above. Explain how this Offer will comply with the
all-holders
      requirement in Rule 13e-4(f)(8)(i), given that some warrant holders may
not qualify to
      participate in the Offer and the Financing Transaction, participation in
which is a
      condition to participation in the Offer.

The Offer, page 4

   6. Clarify when the Financing Transaction and the Reverse Stock Split will
occur in relation
      to the Offer. All Offer conditions other than those related to necessary
regulatory
      approvals must be satisfied or waived on or before the Expiration Date of
the Offer.

Conditions; Termination; Waivers; Extensions; Amendments, page 11
 Lawrence Remmel, Esq.
Pryor Cashman, LLP
June 7, 2019
Page 3


   7. In condition iv.a, explain what it meant by a "limitation on prices for,
trading in securities
      in U.S. securities or financial markets."

   8. In condition iv.b, revise to state the percentage change in the price of
the Shares that
      would trigger this condition. Include the reference point by date or
Share price from
      which such change is to be measured.

   9. In the same offer condition, clarify what is meant by a material adverse
change in the
      price of "U.S. securities or financial markets" and explain how such a
change would be
      measured.

Forward-Looking Statements; Risk Factors, page 13

   10. Please delete the reference to Section 27A of the Securities Act and
Section 21E of the
       Exchange Act. The safe harbor for forward looking statements contained
in those
       provisions does not apply to statements made in connection with a tender
offer.

Schedule TO-I/A   Amended Offer to Exchange

   11. We note that you revised the terms of the exchange offer. In your
response letter, tell us
       how you disseminated the revised disclosure document.

   12. We note the new disclosure that you have engaged Maxim Group LLC to
assist with the
       Financing Transaction. If Maxim Group will play a role in the Offer
also, please
       describe, including any fees to be paid to that entity. In this regard,
we note that
       participation in the Financing Transaction is a condition to being able
to tender into the
       exchange offer.

          We remind you that the filing persons are responsible for the
accuracy and adequacy of
   their disclosures, notwithstanding any review, comments, action or absence
of action by the
   staff. Please contact me at (202) 551- 3263 with any questions about these
comments.


                                                     Sincerely,

                                                     /s/ Christina Chalk

                                                     Christina Chalk
                                                     Senior Special Counsel
                                                     Office of Mergers and
Acquisitions