August 8, 2019 Jigar Raythatha Chief Executive Officer Constellation Pharmaceuticals, Inc. 215 First Street, Suite 200 Cambridge, MA 02142 Re: Constellation Pharmaceuticals, Inc. Registration Statement on Form S-3 Filed August 2, 2019 File No. 333-232992 Dear Mr. Raythatha: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Jeffrey Gabor at 202-551-2544 with any questions. Sincerely, Division of Corporation Finance Office of Healthcare & Insurance cc: Lia Der Marderosian, Esq.