October 7, 2019

Robb Knie
Chief Executive Officer
Hoth Therapeutics, Inc.
1 Rockefeller Plaza, Suite 1039
New York, NY 10020

       Re: Hoth Therapeutics, Inc.
           Registration Statement on Form S-1
           Filed September 26, 2019
           File No. 333-233954

Dear Mr. Knie:

       We have limited our review of your registration statement to those
issues we have
addressed in our comment.

       Please respond to this letter by amending your registration statement
and providing the
requested information. If you do not believe our comment applies to your facts
and
circumstances or do not believe an amendment is appropriate, please tell us why
in your
response.

       After reviewing any amendment to your registration statement and the
information you
provide in response to this comment, we may have additional comments.

Registration Statement on Form S-1

General

1.     It appears that you have elected to incorporate certain information by
reference into the
       prospectus, including your financial statements. Please provide the
disclosure required by
       Item 12(a) of Form S-1.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.
 Robb Knie
Hoth Therapeutics, Inc.
October 7, 2019
Page 2

      Please contact Ada D. Sarmento at 202-551-3798 or Christine Westbrook at
202-551-
5019 with any questions.



                                                        Sincerely,
FirstName LastNameRobb Knie
                                                        Division of Corporation
Finance
Comapany NameHoth Therapeutics, Inc.
                                                        Office of Life Sciences
October 7, 2019 Page 2
cc:       Richard A. Friedman, Esq.
FirstName LastName