November 14, 2019

Lonnel Coats
President and Chief Executive Officer
Lexicon Pharmaceuticals, Inc.
8800 Technology Forest Place
The Woodlands, Texas 77381-1160

       Re: Lexicon Pharmaceuticals, Inc.
           Registration Statement on Form S-3
           Filed November 7, 2019
           File No. 333-234568

Dear Mr. Coats:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Irene Paik at 202-551-6553 with any questions.



                                                            Sincerely,

                                                            Division of
Corporation Finance
                                                            Office of Life
Sciences
cc:    David P. Oelman - Vinson & Elkins L.L.P.