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                           May 27, 2020

       Frank D. Lee
       President and Chief Executive Officer
       Forma Therapeutics Holdings, Inc.
       500 Arsenal Street, Suite 100
       Watertown, Massachusetts 02472

                                                        Re: Forma Therapeutics
Holdings, Inc.
                                                            Amendment No. 2 to
                                                            Draft Registration
Statement on Form S-1
                                                            Submitted May 15,
2020
                                                            CIK No. 0001538927

       Dear Mr. Lee:

            We have reviewed your amended draft registration statement and have
the following
       comment.

              Please respond to this letter by providing the requested
information and either submitting
       an amended draft registration statement or publicly filing your
registration statement on
       EDGAR. If you do not believe our comment applies to your facts and
circumstances or do not
       believe an amendment is appropriate, please tell us why in your
response.

             After reviewing the information you provide in response to this
comment and your
       amended draft registration statement or filed registration statement, we
may have additional
       comments.

       Amendment No. 2 to Draft Registration Statement on Form S-1 submitted
May 15, 2020

       Business
       Partnered Programs, page 121

   1.                                                   We note your response
to our prior comment 9 and reissue the comment in part. Please
                                                        revise your disclosure
regarding the Boehringer Ingelheim agreement to include aggregate
                                                        payments received to
date and aggregate milestone payments receivable.
 Frank D. Lee
FirstName LastNameFrank D. Lee
Forma Therapeutics Holdings, Inc.
Comapany NameForma Therapeutics Holdings, Inc.
May 27, 2020
Page 2
May 27, 2020 Page 2
FirstName LastName
        You may contact Christie Wong at (202) 551-3684 or Angela Connell at
(202) 551-
3426 if you have questions regarding the financial statements and related
matters. Please contact
Abby Adams at (202) 551-6902 or Irene Paik at (202) 551-6553 with any other
questions.



                                                            Sincerely,

                                                            Division of
Corporation Finance
                                                            Office of Life
Sciences
cc:      Gabriela Morales-Rivera