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                           June 5, 2020

       Corey Fishman
       President and Chief Executive Officer
       Iterum Therapeutics plc
       200 South Wacker Drive, Suite 2550
       Chicago, IL 60606

                                                        Re: Iterum Therapeutics
plc
                                                            Amendment No. 2 to
Registration Statement on Form S-1
                                                            Response dated May
21, 2020
                                                            File No. 333-237326

       Dear Mr. Fishman:

              We have reviewed your May 21, 2020 response to our comment letter
and have the
       following comment.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comments apply to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to these comments, we may have additional comments.
Unless we note
       otherwise, our references to prior comments are to comments in our May
14, 2020 letter.

       Response Dated May 21, 2020

       General

   1.                                                   We note your response
to prior comment 1. To assist in our understanding and analysis of
                                                        your response, please
supplementally furnish the Indenture and any other applicable
                                                        governing documents
pertaining to the intra-group loan arrangement between the
                                                        Company and Iterum
Bermuda.
 Corey Fishman
FirstName LastNameCorey Fishman
Iterum Therapeutics plc
Comapany NameIterum Therapeutics plc
June 5, 2020
Page 2
June 5, 2020 Page 2
FirstName LastName
       You may contact Jeffrey Gabor at 202-551-2544 or Joe McCann at
202-551-6262 with
any questions.



                                                       Sincerely,

                                                       Division of Corporation
Finance
                                                       Office of Life Sciences
cc:      Brian A. Johnson, Esq.