United States securities and exchange commission logo June 5, 2020 Corey Fishman President and Chief Executive Officer Iterum Therapeutics plc 200 South Wacker Drive, Suite 2550 Chicago, IL 60606 Re: Iterum Therapeutics plc Amendment No. 2 to Registration Statement on Form S-1 Response dated May 21, 2020 File No. 333-237326 Dear Mr. Fishman: We have reviewed your May 21, 2020 response to our comment letter and have the following comment. Please respond to this letter by amending your registration statement and providing the requested information. If you do not believe our comments apply to your facts and circumstances or do not believe an amendment is appropriate, please tell us why in your response. After reviewing any amendment to your registration statement and the information you provide in response to these comments, we may have additional comments. Unless we note otherwise, our references to prior comments are to comments in our May 14, 2020 letter. Response Dated May 21, 2020 General 1. We note your response to prior comment 1. To assist in our understanding and analysis of your response, please supplementally furnish the Indenture and any other applicable governing documents pertaining to the intra-group loan arrangement between the Company and Iterum Bermuda. Corey Fishman FirstName LastNameCorey Fishman Iterum Therapeutics plc Comapany NameIterum Therapeutics plc June 5, 2020 Page 2 June 5, 2020 Page 2 FirstName LastName You may contact Jeffrey Gabor at 202-551-2544 or Joe McCann at 202-551-6262 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Brian A. Johnson, Esq.