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                          August 18, 2020

       Jim Biehl
       Chief Legal Officer
       TYME TECHNOLOGIES, INC.
       1 Pluckemin Way, Suite 103
       Bedminster, NJ 07921

                                                        Re: TYME TECHNOLOGIES,
INC.
                                                            Registration
Statement on Form S-3
                                                            Filed August 12,
2020
                                                            File No. 333-245033

       Dear Mr. Biehl:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Margaret
Schwartz at 202-551-7153 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences