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                           August 18, 2020

       Valentios Valentis
       Chairman and Chief Executive Officer
       Pyxis Tankers Inc.
       59 K. Karamanli Street
       15125 Maroussi, Greece

                                                        Re: Pyxis Tankers Inc.
                                                            Registration
Statement on Form F-1
                                                            Filed August 13,
2020
                                                            FIle No. 333-245405

       Dear Mr. Valentis:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Karina
Dorin, Attorney Advisor, at (202) 551-3763 with any questions.




                           Sincerely,


                           Division of Corporation Finance

                           Office of Energy & Transportation
       cc:                                              Keith Billotti