United States securities and exchange commission logo August 18, 2020 Valentios Valentis Chairman and Chief Executive Officer Pyxis Tankers Inc. 59 K. Karamanli Street 15125 Maroussi, Greece Re: Pyxis Tankers Inc. Registration Statement on Form F-1 Filed August 13, 2020 FIle No. 333-245405 Dear Mr. Valentis: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Karina Dorin, Attorney Advisor, at (202) 551-3763 with any questions. Sincerely, Division of Corporation Finance Office of Energy & Transportation cc: Keith Billotti