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                            October 20, 2020

       Andrew McDonald
       Chief Executive Officer
       Lifesci Acquisition II Corp.
       250 W 55th St #3401
       New York, NY 10019

                                                        Re: Lifesci Acquisition
II Corp.
                                                            Registration
Statement on Form S-1
                                                            Filed October 14,
2020
                                                            File No. 333-249480

       Dear Mr. McDonald:

              We have reviewed your registration statement and have the
following comments. In
       some of our comments, we may ask you to provide us with information so
we may better
       understand your disclosure.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comments apply to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to these comments, we may have additional comments.

       Registration Statement on Form S-1 filed October 14, 2020

       Principal Stockholders, page 73

   1.                                                   Please revise your
tabular disclosure to identify the natural person(s) who have sole or
                                                        shared voting or
investment power for the securities beneficially owned by Chardan
                                                        Healthcare Investments
LLC. For guidance, please refer to Item 403 of Regulation S-K.
               We remind you that the company and its management are
responsible for the accuracy
       and adequacy of their disclosures, notwithstanding any review, comments,
action or absence of
       action by the staff.

              Refer to Rules 460 and 461 regarding requests for acceleration.
Please allow adequate
       time for us to review any amendment prior to the requested effective
date of the registration
       statement.
 Andrew McDonald
Lifesci Acquisition II Corp.
October 20, 2020
Page 2

       You may contact Joanna Lam, Staff Accountant, at (202) 551-3476 or Raj
Rajan, Staff
Accountant, at (202) 551-3388 if you have questions regarding comments on the
financial
statements and related matters. Please contact Anuja A. Majmudar,
Attorney-Adviser, at (202)
551-3844 or, in her absence, Loan Lauren Nguyen, Legal Branch Chief, at (202)
551-3642 with
any other questions.



                                                         Sincerely,
FirstName LastNameAndrew McDonald
                                                         Division of
Corporation Finance
Comapany NameLifesci Acquisition II Corp.
                                                         Office of Energy &
Transportation
October 20, 2020 Page 2
cc:       Giovanni Caruso
FirstName LastName