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                          November 18, 2020

       Michael S. Lebby
       Chief Executive Officer
       Lightwave Logic, Inc.
       369 Inverness Parkway, Suite 350
       Englewood, Colorado 80112

                                                        Re: Lightwave Logic,
Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed November 13,
2020
                                                            File No. 333-250088

       Dear Dr. Lebby:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Thomas
Jones at 202-551-3602 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Manufacturing
       cc:                                              Clayton E. Parker, Esq.