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                              November 23, 2020

       Kevin J. Knopp
       Chief Executive Officer
       908 Devices Inc.
       645 Summer Street
       Boston, MA 02210

                                                        Re: 908 Devices Inc.
                                                            Amendment No. 1 to
Draft Registration Statement on Form S-1
                                                            Submitted November
6, 2020
                                                            CIK No. 0001555279

       Dear Mr. Knopp:

             We have reviewed your amended draft registration statement and
have the following
       comments. In some of our comments, we may ask you to provide us with
information so we
       may better understand your disclosure.

              Please respond to this letter by providing the requested
information and either submitting
       an amended draft registration statement or publicly filing your
registration statement on
       EDGAR. If you do not believe our comments apply to your facts and
circumstances or do not
       believe an amendment is appropriate, please tell us why in your
response.

             After reviewing the information you provide in response to these
comments and your
       amended draft registration statement or filed registration statement, we
may have additional
       comments.

       Amendment No. 1 to Draft Registration Statement submitted on November 6,
2020

       Prospectus Summary
       Overview, page 1

   1.                                                   We note your response
to comment 1, which we reissue in part. We note your disclosure
                                                        that you foresee
significant future opportunity from the government sector and that you
                                                        believe your investment
with certain prospects creates a predictable pipeline of
                                                        opportunity for your
devices and their entrenchment. Please revise your disclosure to
                                                        remove any implication
that you will be successful in securing any particular sales to the
                                                        public sector.
 Kevin J. Knopp
908 Devices Inc.
November 23, 2020
Page 2
Business
Licenses, page 108

2.    We note your response to comment 9 and reissue the comment to the extent
that you
      have not revised the disclosure in this subsection to more specifically
describe the subject
      of the UT-Battelle licenses. Additionally, your disclosure indicates that
your licenses will
      continue until the last expired patent or last abandoned licensed patent
application. Please
      clarify your revised disclosure indicating the license agreements are
expected to expire in
      2035 and 2040, whereas above you state your in-licensed patents are
expected to expire
      between 2020 and 2029.
       You may contact Christine Torney at 202-551-3652 or Brian Cascio at
202-551-3676 if
you have questions regarding comments on the financial statements and related
matters. Please
contact Abby Adams at 202-551-6902 or Christine Westbrook at 202-551-5019 with
any other
questions.



                                                            Sincerely,
FirstName LastNameKevin J. Knopp
                                                            Division of
Corporation Finance
Comapany Name908 Devices Inc.
                                                            Office of Life
Sciences
November 23, 2020 Page 2
cc:       Michael J. Minihan, Esq.
FirstName LastName