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                             April 27, 2021

       Daniel B. Silvers
       Chief Executive Officer
       Leisure Acquisition Corp.
       250 West 57th Street , Suite 415
       New York , NY 10107

                                                        Re: Leisure Acquisition
Corp.
                                                            Amendment No. 1 to
Registration Statement on Form S-4
                                                            Filed April 16,
2021
                                                            Amendment No. 2 to
Registration Statement on Form S-4
                                                            Filed April 19,
2021
                                                            Amendment No. 3 to
Registration Statement on Form S-4
                                                            Filed April 21,
2021
                                                            File No. 333-254279

       Dear Mr. Silvers:

             We have reviewed your amended registration statement and have the
following
       comments. In some of our comments, we may ask you to provide us with
information so we
       may better understand your disclosure.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comments apply to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to these comments, we may have additional comments.
Unless we note
       otherwise, our references to prior comments are to comments in our April
11, 2021 letter.

       Amendment No. 3 to Registration Statement on Form S-4

       The Merger
       Financial Terms, page 84

   1.                                                   We note your response
to prior comment 12 and reissue in part. Please expand your
                                                        disclosure to discuss
the extent to which LACQ's Board of Directors relied on the
                                                        financial projections
provided by Ensysce to support its decision to approve the
                                                        Transactions. In this
regard, clarify whether the projections were accepted or whether
 Daniel B. Silvers
FirstName   LastNameDaniel
Leisure Acquisition Corp. B. Silvers
Comapany
April       NameLeisure Acquisition Corp.
       27, 2021
April 227, 2021 Page 2
Page
FirstName LastName
         management or the Board made any adjustments to these projections and
if so, describe
         such adjustments.
Unaudited Pro Forma Condensed Combined Financial Information
Pro Forma Adjustments to the Unaudited Combined Balance Sheet, page 125

2.       Refer to prior comment 15. Please tell us the nature of the $5 million
payable to one of
         Ensysce   s vendors, where else you disclose this transaction in the
filing, and why the
         amount is accounted for as an expense of the business combination.
3.       Please refer to prior comment 16. Please disclose the significant
assumptions underlying
         your Black-Scholes valuation of the GEM warrants.
Pro Forma Adjustments to the Unaudited Combined Statements of Operations, page
127

4.       Please refer to prior comment 15. Please tell us why you do not
reflect the transaction
         costs in the statement of operations and explain in the notes whether
you expect the
         transaction costs to recur.
Information about Ensysce
PF614-101 Phase 1 Clinical Trial, page 156

5.       We note your response to prior comment 21, which we reissue in part.
Please revise to
         indicate how many doses of PF614 or OxyContin OP were administered to
each subject
         and the time period over which the doses were administered to each
subject.
Ensysce's Management's Discussion and Analysis of Financial Condition and
Results of
Operations of Ensysce
Liquidity and capital resources, page 175

6.       We note your response to prior comment 25 and reissue. With respect to
the federal
         research grants, please disclose the material terms of the grants
including, but not limited
         to, (i) your obligations under the grants, (ii) whether the grants
must be repaid, (iii) the
         process for obtaining the remaining funding pursuant to the grants and
(iv) whether the
         government has any rights with respect to the intellectual property
and/or product
         candidates that are created with grant proceeds. With respect to the
convertible promissory
         notes, please disclose the counterparties, interest rates, repayment
terms, conversion terms
         and whether the consummation of the transactions contemplated by the
registration
         statement will trigger the conversion of the notes. Finally, please
also include a discussion
         of the material terms of the GEM Facility in this section.
 Daniel B. Silvers
Leisure Acquisition Corp.
April 27, 2021
Page 3
Ensysce Biosciences, Inc. Financial Statements
Note 3. Summary of Significant Accounting Policies
Fair Value Measurement, page F-28

7.    Refer to prior comment 31. Please explain why the proposed disclosures do
not include
      quantitative information about the significant unobservable inputs used
in the fair value
      measurement. Refer to ASC 810-10-50-2(bbb)(2). Also, explain to us why
you believe
      that the Form S-4 should not be amended to include the disclosure.
       You may contact Jeanne Bennett at 202-551-3606 or Kate Tillan at
202-551-3604 if you
have questions regarding comments on the financial statements and related
matters. Please
contact Alan Campbell at 202-551-4224 or Christine Westbrook at 202-551-5019
with any other
questions.



                                                            Sincerely,
FirstName LastNameDaniel B. Silvers
                                                            Division of
Corporation Finance
Comapany NameLeisure Acquisition Corp.
                                                            Office of Life
Sciences
April 27, 2021 Page 3
cc:       Daniel L. Forman, Esq.
FirstName LastName