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                              May 11, 2021

       Joshua Goldstein
       General Counsel and Secretary
       Masterworks 043, LLC
       497 Broome Street
       New York, New York 10013

                                                        Re: Masterworks 043,
LLC
                                                            Amended Offering
Statement on Form 1-A
                                                            Filed April 23,
2021
                                                            File No. 024-11457

       Dear Mr. Goldstein:

             We have reviewed your amended offering statement and have the
following
       comments. In some of our comments, we may ask you to provide us with
information so we
       may better understand your disclosure.

              Please respond to this letter by amending your offering statement
and providing the
       requested information. If you do not believe our comments apply to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your offering statement and the
information you
       provide in response to these comments, we may have additional comments.
Unless we note
       otherwise, our references to prior comments are to comments in our April
20, 2021 letter.

       Amended Offering Statement on Form 1-A

       General

   1.                                                   We note your response
to prior comment 1. Please disclose what actions you will take
                                                        with respect to the
number of shares issued to the Administrator if you are unable to
                                                        collect the remaining
5% of unpaid funds.
   2.                                                   We note your response
to prior comment 4. However, we are unable to agree with your
                                                        conclusion that
additional risk factor disclosure is unnecessary. To the contrary, the extent
                                                        to which voting control
may shift as a result of the sale or transfer of shares would appear
                                                        to be material to an
investment decision. Please revise your disclosure accordingly.
 Joshua Goldstein
FirstName  LastNameJoshua Goldstein
Masterworks  043, LLC
Comapany
May        NameMasterworks 043, LLC
     11, 2021
May 11,
Page 2 2021 Page 2
FirstName LastName
       You may contact Patrick Kuhn at (202) 551-3308 or Theresa Brillant at
(202) 551-3307 if
you have questions regarding comments on the financial statements and related
matters. Please
contact Daniel Morris at (202) 551-3314 or Lilyanna Peyser at (202) 551-3222
with any other
questions.



                                                          Sincerely,

                                                          Division of
Corporation Finance
                                                          Office of Trade &
Services
cc:      Laura Anthony, Esq.