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                            May 14, 2021

       Gregory C. Critchfield, M.D., M.S.
       President and Chief Executive Officer
       Sera Prognostics, Inc.
       2749 East Parleys Way
       Suite 200
       Salt Lake City, UT 84109

                                                        Re: Sera Prognostics,
Inc.
                                                            Amendment No. 1 to
                                                            Draft Registration
Statement on Form S-1
                                                            Submitted May 5,
2021
                                                            CIK No. 0001534969

       Dear Dr. Critchfield:

             We have reviewed your amended draft registration statement and
have the following
       comments. In some of our comments, we may ask you to provide us with
information so we
       may better understand your disclosure.

              Please respond to this letter by providing the requested
information and either submitting
       an amended draft registration statement or publicly filing your
registration statement on
       EDGAR. If you do not believe our comments apply to your facts and
circumstances or do not
       believe an amendment is appropriate, please tell us why in your
response.

             After reviewing the information you provide in response to these
comments and your
       amended draft registration statement or filed registration statement, we
may have additional
       comments.

       Amendment No. 1 to Draft Registration Statement on Form S-1

       Our Pipeline, page 4

   1.                                                   We note your response
to prior comment 3. Please revise your pipeline table to add a
                                                        column identifying your
next anticipated milestone or in a similar way that provides
                                                        investors context as to
when they may expect your product candidates to be developed.
       Principal Stockholders, page 39

   2.                                                   We note your response
to prior comment 9. Please revise to identify the natural
                                                        person(s) with voting
and/or dispositive power over the shares held by:
 Gregory C. Critchfield, M.D., M.S.
Sera Prognostics, Inc.
May 14, 2021
Page 2
             Entities affiliated with Domain Associates, LLC;
             Laboratory Corporation of America Holdings; and
             Vivo Capital Fund IX, LP.
Material Agreements
Labcorp Agreement, page 100

3.    Please revise to disclose how many years your agreement with Labcorp
extends for unless
      it its terminated earlier.
Item 16. Exhibits and Financial Statement Schedules, page II-3

4.    We note your revised disclosure under Board Composition on page 121.
Please file your
      agreement with Baker Bros. Advisors LP as an exhibit to your registration
statement.
       You may contact Tracey McKoy at 202-551-3772 or Kevin Kuhar at
202-551-3662 if
you have questions regarding comments on the financial statements and related
matters. Please
contact David Gessert at 202-551-2326 or Celeste Murphy at 202-551-3257 with
any other
questions.



                                                           Sincerely,
FirstName LastNameGregory C. Critchfield, M.D., M.S.
                                                           Division of
Corporation Finance
Comapany NameSera Prognostics, Inc.
                                                           Office of Life
Sciences
May 14, 2021 Page 2
cc:       Megan N. Gates
FirstName LastName