United States securities and exchange commission logo May 26, 2021 Anna Paglia Chief Executive Officer Invesco DB Multi-Sector Commodity Trust Invesco DB Base Metals Fund 3500 Lacey Road, Suite 700 Downers Grove, Illinois 60515 Re: Invesco DB Multi-Sector Commodity Trust Invesco DB Base Metals Fund Registration Statement on Form S-3 Filed May 21, 2021 File No. 333-256371 Dear Ms. Paglia: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Julia Griffith at 202-551-3267 with any questions. Sincerely, Division of Corporation Finance Office of Finance