United States securities and exchange commission logo June 10, 2021 Feng Tian Chairman, President and Chief Executive Officer Ambrx Biopharma Inc. 10975 North Torrey Pines Road La Jolla, California 92037 Re: Ambrx Biopharma Inc. Registration Statement on Form F-1 Filed May 28, 2021 File No. 333-256639 Dear Dr. Tian: We have reviewed your registration statement and have the following comments. In some of our comments, we may ask you to provide us with information so we may better understand your disclosure. Please respond to this letter by amending your registration statement and providing the requested information. If you do not believe our comments apply to your facts and circumstances or do not believe an amendment is appropriate, please tell us why in your response. After reviewing any amendment to your registration statement and the information you provide in response to these comments, we may have additional comments. Registration Statement on Form F-1, Filed May 28, 2021 Business Legal Proceedings, page 210 1. We note your disclosure on pages 210-211 concerning the termination of your CFO. Please revise to provide the findings of the independent investigation and disclose whether severance or other amounts are payable. Description of American Depositary Shares, page 245 2. We note Section 20 of the Deposit Agreement filed as Exhibit 4.2 and your revisions to page 260. We note on page 259 that your forum selection provision identifies state and federal courts in New York, New York as the exclusive forum for certain litigation. Please disclose whether this provision applies to actions arising under the Securities Act or Feng Tian Ambrx Biopharma Inc. June 10, 2021 Page 2 Exchange Act. If so, please also state that there is uncertainty as to whether a court would enforce such provision. If the provision applies to Securities Act claims, please also state that investors cannot waive compliance with the federal securities laws and the rules and regulations thereunder. In that regard, we note that Section 22 of the Securities Act creates concurrent jurisdiction for federal and state courts over all suits brought to enforce any duty or liability created by the Securities Act or the rules and regulations thereunder. If this provision does not apply to actions arising under the Securities Act or Exchange Act, please also ensure that the exclusive forum provision in the governing documents and Deposit Agreement states this clearly, or tell us how you will inform investors in future filings that the provision does not apply to any actions arising under the Securities Act or Exchange Act. 3. Please revise page 260 to state, as stated in the Deposit Agreement, that in any case where the Depositary exercises its right to arbitrate, arbitration of the relevant dispute is mandatory. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Refer to Rules 460 and 461 regarding requests for acceleration. Please allow adequate time for us to review any amendment prior to the requested effective date of the registration statement. You may contact Michael Fay at 202-551-3812 or Brian Cascio at 202-551-3676 if you have questions regarding comments on the financial statements and related matters. Please contact Margaret Schwartz at 202-551-7153 or Laura Crotty at 202-551-7614 with any other questions. Sincerely, FirstName LastNameFeng Tian Division of Corporation Finance Comapany NameAmbrx Biopharma Inc. Office of Life Sciences June 10, 2021 Page 2 cc: Sean Clayton, Esq. FirstName LastName