United States securities and exchange commission logo June 28, 2021 Anna Paglia Chief Executive Officer Invesco Capital Management LLC 3500 Lacey Road, Suite 700 Downers Grove, IL 60515 Re: Invesco DB Multi-Sector Commodity Trust Registration Statement on Form S-3 Filed June 22, 2021 File No. 333-257270 Dear Ms. Paglia: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact David Lin, Staff Attorney, at (202) 551-3552 with any questions. Sincerely, Division of Corporation Finance Office of Finance