July 1, 2021 Via Email David P. Glatz Stradley Ronan Steven & Young, LLP 191 N. Wacker Dr. Suite 1601 Chicago, IL 60606 dglatz@stradley.com Re: Nuveen Variable Rate Preferred & Income Fund Registration Statement on Form N-2 File Nos. 333-256744, 811-23704 Dear Mr. Glatz: On June 3, 2021, you filed a registration statement on Form N-2 on behalf of Nuveen Variable Rate Preferred & Income Fund (the Fund ). We have reviewed the registration statement and have provided our comments below. Where a comment is made in one location, it is applicable to all similar disclosure appearing elsewhere in the registration statement. All capitalized terms not otherwise defined herein have the meaning given to them in the registration statement. 1. Please tell us if you have presented any test the waters materials to potential investors in connection with this offering. If so, please contact us to discuss how to provide us with copies of such materials. PROSPECTUS Outside Front Cover, Page ii 2. In the third line of the paragraph titled, Investment Policies, disclosure states, The Fund will invest at least 50% of its Managed Assets in securities that, at the time of investment, are rated investment grade (rated BBB/Baa or higher) or are unrated but judged to be of comparable quality by the Fund s sub-adviser. Please add disclosure that clarifies how much the Fund intends to invest in below-investment grade securities. 3. In the third line of the paragraph titled, Investment Policies, disclosure states, Additionally, the Fund will invest more than 25% of its Managed Assets in the securities of companies principally engaged in financial services. Disclosure here and throughout the registration statement (e.g., page 50 regarding Investment Policies, page 82 regarding Concentration and Financial Services Sector Risk, page 8 of the Statement of Additional 1 Information regarding Investment Restrictions ) refers variously to the Fund concentrating in financial services and that financial services is a sector or an industry. It is therefore difficult to understand what the Fund s policy is regarding concentration in an industry. Please revise disclosure throughout the registration statement accordingly. 4. In the twelfth line of the paragraph titled, Leverage, disclosure states, In addition, the Fund may use derivatives that have the economic effect of leverage. Please tell us how the Fund calculates its derivative positions for purposes of meeting the Fund s 80% test. Page 3 Preferred Securities 5. In the third line of the fourth paragraph, disclosure states, The retail segment is typified by $25 par value exchange-traded securities and the institutional segment is typified by $1,000 par value OTC securities. Both $25 and $1,000 par value securities are often callable at par value, typically at least five years after their original issuance date. Please revise this disclosure using plain English. Page 6 Other Equity Securities 6. In the second line, disclosure states, Additional types of equity securities (other than preferred securities) in which the Fund may invest include convertible securities (discussed below), real estate investment trusts ( REITs ), warrants, rights, depositary receipts (which reference ownership of underlying non-U.S. securities) and other types of securities with equity characteristics. Please specify the other types of securities with equity characteristics. Page 10 Investment Policies 7. In the second line of the second paragraph, disclosure refers to IMF. Please define the term. Page 19 Special Redemption Rights Risk 8. In the first line, disclosure states, In certain circumstances, an issuer of preferred securities may redeem the securities at par prior to their stated maturity date. Please revise this sentence using plain English. Page 21 Contingent Capital Securities or Contingent Convertible Securities 9. In the third line, disclosure states, CoCos generally provide for mandatory conversion into the common stock of the issuer or a write-down of the principal amount or value of the CoCos upon the occurrence of certain triggers. These triggers are generally linked to regulatory capital thresholds or regulatory actions calling into question the issuing banking institution s continued viability as a going-concern. Equity conversion or principal write- down features are tailored to the issuer and its regulatory requirements and, unlike traditional 2 convertible securities, conversions are not voluntary. Please revise this disclosure using plain English. Page 47 Summary of Fund Expenses 10. Earlier disclosure refers to the Fund s use of various swaps as a principal investment strategy. If the Fund will derive its returns principally from swaps, please include a footnote to the fee table disclosing the cost of investing in swaps. The footnote should explain that the embedded cost of the swaps, and the operating expenses of any reference assets, are indirect expenses of the Fund that are not included in either the fee table or the expense example. Please also provide an estimate of such costs, as a percentage of Fund assets for the most recent fiscal year. Page 79 Debt Securities Risk 11. In the first line of the second paragraph, disclosure states, Additionally, the Fund may be exposed to certain debt securities risks through its sukuk investments. This is the first mention of sukuk investments. Please add disclosure about sukuk investments to the strategy section, and ensure that there is enough detail for the reader to have a basis to understand the disclosure here. Page 91 Inverse Floating Rate Securities Risk 12. In the first line of the first paragraph, disclosure states, The Fund may invest in inverse floating rate securities issued by special purpose trusts that have recourse to the Fund. In Nuveen Fund Advisors and Nuveen Asset Management s discretion, the Fund may enter into a separate shortfall and forbearance agreement with the third party granting liquidity to the floating rate security holders of the special purpose trust. Please revise this disclosure using plain English. Page 109 Redemption, Purchase and Sale of Preferred Shares 13. If applicable, please discuss any limitations or restrictions on the Fund if dividend payments are past due. Please also disclose any restrictions on paying dividends. See Item 10.1.b. of Form N-2. STATEMENT OF ADDITIONAL INFORMATION Page 8 Investment Restrictions 14. Regarding the fourth investment restriction, the Fund s concentration policy appears to reserve discretion as to when or whether the Fund would concentrate. It has been the staff s longstanding position that a fund may not change its policies with respect to concentration without a shareholder vote, whether or not the fund previously disclosed that it may do so, unless the statement of investment policy clearly indicates when and under what conditions any changes between concentration and non-concentration would be made. Therefore, please revise the Fund s policy to remove this discretion or to clearly indicate when and under what conditions 3 those changes would be made. See Statements of Investment Policies of Money Market Funds Relating to Industry Concentration, Investment Company Act Release No. 9011 (Oct. 30, 1975). PART C Item 25: Financial Statements and Exhibits 15. Please confirm that the Fund s By-laws do not substantively differ from the By-laws of the existing Nuveen closed-end funds regarding mandatory arbitration, control share acquisitions, jury trial waiver, exclusive forum, and derivative actions. * * * * * * We note that portions of the filing are incomplete. We may have additional comments on such portions when you complete them in a pre-effective amendment, on disclosures made in response to this letter, on information provided supplementally, or on exhibits added in any pre- effective amendment. A response to this letter should be in the form of a pre-effective amendment filed pursuant to Rule 472 under the Securities Act. The pre-effective amendment filing should be accompanied by a supplemental letter that includes your responses to each of these comments. Where no change will be made in the filing in response to a comment, please indicate this fact in your supplemental letter and briefly state the basis for your position. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action, or absence of action by the staff. Should you have any questions regarding this letter, please contact me at (202) 551-5166. Sincerely, /s/ Lisa N. Larkin Senior Counsel cc: John Lee, Branch Chief Christian Sandoe, Assistant Director 4