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                               July 12, 2021

       Brian Emes
       Chief Financial Officer
       CM Life Sciences II Inc.
       c/o Corvex Management LP
       667 Madison Avenue
       New York, NY 10065

                                                        Re: CM Life Sciences II
Inc.
                                                            Amendment No. 1 to
Registration Statement on Form S-4
                                                            Filed June 25, 2021
                                                            File No. 333-256127

       Dear Mr. Emes:

             We have reviewed your amended registration statement and have the
following
       comments. In some of our comments, we may ask you to provide us with
information so we
       may better understand your disclosure.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comments apply to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to these comments, we may have additional comments.
Unless we note
       otherwise, our references to prior comments are to comments in our June
10, 2021 letter.

       Amendment No. 1 to Registration Statement on Form S-4 filed June 25,
2021

       Risk Factors, page 47

   1.                                                   Please revise to
disclose the material risks to unaffiliated investors presented by taking the
                                                        company public through
a merger rather than an underwritten offering. These risks could
                                                        include the absence of
due diligence conducted by an underwriter that would be subject to
                                                        liability for any
material misstatements or omissions in a registration statement.
       "Sponsor, certain members of the Board and officers of CMLS II ...",
page 90

   2.                                                   We note your risk
factor on page 90 that the sponsor, certain members of the Board, and
                                                        officers of CMLS II
will benefit from the completion of a business combination. Please
 Brian Emes
FirstName  LastNameBrian
CM Life Sciences II Inc. Emes
Comapany
July       NameCM Life Sciences II Inc.
     12, 2021
July 12,
Page  2 2021 Page 2
FirstName LastName
         revise to highlight that these parties may be incentivized to complete
an acquisition of a
         less favorable target company or on terms less favorable to
shareholders rather than
         liquidate. Further, please revise to clarify if the sponsor and its
affiliates can earn a
         positive rate of return on their investment, even if other SPAC
shareholders experience a
         negative rate of return in the post-business combination company.
"CMLS II and SomaLogic will incur significant transaction and transaction costs
....", page 95

3.       We note that the aggregate transaction expenses as a result of the
Business Combination
         are expected to be approximately $35 million. Please revise to include
the current value
         of securities held, loans extended, fees due, and out-of-pocket
expenses for which the
         sponsor and its affiliates are awaiting reimbursement. Provide similar
disclosure for the
         company   s officers and directors, if material.
"CMLS II may redeem unexpired public warrants prior to their exercise ...",
page 101

4.       We note that this risk factor addresses risks relating to the
redemption of Class A common
         stock when it is trading at or above $18.00. Please revise to also
include any risks relating
         to the redemption of Class A common stock when it is trading at or
above $10.00 per
         share, as we note that your Class A common stock is currently trading
above $10.00.
         Specifically, revise to clarify that recent common stock trading
prices exceed the threshold
         that would allow the company to redeem public warrants.
Unaudited Pro Forma Condensed Combined Financial Information, page 108

5.       The pro forma financial information assumes no cash elections will be
made by
         SomaLogic stockholders. Please discuss all pro forma financial
information that would be
         affected should such elections be made. In doing so, give effect to a
reasonable range of
         possible results. Refer to Rule 11-02(a)(10) for guidance.
6.       The notes to the financial statements of SomaLogic disclose SomaLogic
issued on March
         30, 2021 a notice of prepayment to the holder of the convertible debt
stating SomaLogic
         intends to prepay the full outstanding debt obligation in June 2021.
Please disclose the
         status of this notice and reflect the status in the pro forma
financial information as
         appropriate.
7.       The pro forma information assumes SomaLogic's convertible debt is
first converted into
         SomaLogic preferred stock prior to the business combination and then
converted into
         CMLS II Class A common stock. The notes to the financial statements of
SomaLogic
         included in the filing state this convertible debt may be converted
into either SomaLogic
         common stock or preferred stock, with different conversion factors
between the two. To
         the extent applicable after consideration of the preceding comment,
please state the basis
         for assuming this debt is to be converted into preferred stock. If
different conversion
         elections are permissible and applicable, give effect to a reasonable
range of possible
         results of each of them, including how the number of shares associated
with each was
         determined.
 Brian Emes
CM Life Sciences II Inc.
July 12, 2021
Page 3
Background of the Business Combination, page 146

8.       We note your amended disclosure in response to comment 5. To the
extent you entered
         into discussions or had term sheets with your potential acquisition
targets, please revise to
         state as much and include information on how you determined to cease
discussions with
         such parties. If you did not enter into discussions with any of the
six other potential target
         companies, please revise to state as much.
9.       We note your amended disclosure in response to comment 6. Please
revise to disclose the
         information that Casdin Capital and Mr. Casdin received in connection
with making a
         decision to invest in SomaLogic in the Series A preferred stock
private funding round.
         Also, please revise to disclose the date(s) on which CM Life Sciences,
Inc. ceased
         conversions with SomaLogic and entered into an exclusivity arrangement
with the other
         business combination target.
10.      We note your amended disclosure in response to comment 11. We note
your disclosure
         on page 149 that Mr. Casdin received "board materials and drafts of
the Merger
         Agreement and other documents related to the Business Combination."
Please tell us
         what "other documents" Mr. Casdin received.
Opinion of Financial Advisor to CMLS II, page 153

11.      We note that the Enterprise Value to Revenue estimates used in the
Selected Companies
         Analysis on page 157 differs from the estimates in the Investor
Presentation dated March
         29, 2021, filed as exhibit 99.2 to the Form 8-K filed on March 29,
2021. Please revise
         your disclosure to explain the reasons for such differences.
Certain SomaLogic Projected Financial Information, page 158

12.      We note your revised disclosure and response to comment 13. Please
confirm whether the
         projections included in the prospectus are the same financial
projections used by the board
         in making its decision to enter into the business combination and used
by Houlian for its
         fairness opinion.
Material United States Federal Income Tax Considerations for Public
Stockholders Exercising
Redemption Rights, page 164

13.    In addition to the disclosure you have provided in this section
regarding the exercise of
       redemption rights, please include a discussion of the federal income tax
consequences of
       the merger. In this regard, we note the Agreement and Plan of Merger
provides that the
       merger is intended to constitute a    reorganization    within the
meaning of Section 368(a)
FirstName LastNameBrian Emes
       of the Internal Revenue Code. Please also include a tax opinion from
counsel as
Comapany    NameCMPlease
       appropriate.    Life Sciences   II Inc.
                             refer to Item  4(a)(6) of Form S-4 and Section
III.A. of Staff Legal
July 12,Bulletin 19. 3
         2021 Page
FirstName LastName
 Brian Emes
FirstName  LastNameBrian
CM Life Sciences II Inc. Emes
Comapany
July       NameCM Life Sciences II Inc.
     12, 2021
July 12,
Page  4 2021 Page 4
FirstName LastName
Conflicts of Interest, page 194

14.      Please disclose the approximate dollar value of Mr. Casdin's interest
in the target based on
         the transaction value and recent trading prices, as compared to the
price paid.
15.      We note your statement that your "Current Charter provides that we
renounce our interest
         in any corporate opportunity offered to any director or officer unless
such opportunity is
         expressly offered to such person solely in his or her capacity as a
director or officer of our
         company and such opportunity is one we are legally and contractually
permitted to
         undertake and would otherwise be reasonable for us to pursue, and to
the extent the
         director or officer is permitted to refer that opportunity to us
without violating another
         legal obligation." Please revise your Conflicts of Interest disclosure
to address whether
         this provision impacted your search for an acquisition target.
       You may contact Suying Li at (202) 551-3335 or Doug Jones at (202)
551-3309 if you
have questions regarding comments on the financial statements and related
matters. Please
contact Cara Wirth at (202) 551-7127 or Dietrich King at (202) 551-8071 with
any other
questions.



                                                                Sincerely,

                                                                Division of
Corporation Finance
                                                                Office of Trade
& Services
cc:      Joel Rubinstein