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                           July 12, 2022

       Paul Mann
       Chairman, Chief Executive Officer and Chief Financial Officer
       ASP Isotopes Inc.
       433 Plaza Real, Suite 275
       Boca Raton, Florida 33432

                                                        Re: ASP Isotopes Inc.
                                                            Amended Draft
Registration Statement on Form S-1
                                                            Submitted June 27,
2022
                                                            CIK No. 0001921865

       Dear Mr. Mann:

             We have reviewed your amended draft registration statement and
have the following
       comments. In some of our comments, we may ask you to provide us with
information so we
       may better understand your disclosure.

              Please respond to this letter by providing the requested
information and either submitting
       an amended draft registration statement or publicly filing your
registration statement on
       EDGAR. If you do not believe our comments apply to your facts and
circumstances or do not
       believe an amendment is appropriate, please tell us why in your
response.

             After reviewing the information you provide in response to these
comments and your
       amended draft registration statement or filed registration statement, we
may have additional
       comments.

       Amended Draft Registration Statement on Form S-1, submitted on June 27,
2022

       Risk Related to Regulatory Compliance
       Our business is and could become subject to a wide variety of extensive
and evolving laws and
       regulations. Failure to comply with such..., page 15

   1.                                                   We note your revised
disclosure in response to previous comment 6 and re-issue the
                                                        comment in part. Please
expand your disclosure to briefly explain the material licenses,
                                                        approvals and permits
you or Klydon have received in connection with the construction or
                                                        operation of the Mo-100
enrichment facility in South Africa. In addition, please specify
                                                        the conditions that are
associated with such licenses, approvals and permits and, if
                                                        material, discuss the
risks that could cause such conditions to not be maintained.
 Paul Mann
FirstName  LastNamePaul Mann
ASP Isotopes  Inc.
Comapany
July       NameASP Isotopes Inc.
     12, 2022
July 12,
Page  2 2022 Page 2
FirstName LastName
Use of Proceeds, page 42

2.       Please disclose the approximate amount intended to be used to initiate
and fully fund
         Phase 2 of the Mo-100 development plan under the turnkey contract.
Letter of Intent for Klydon Shares or Assets, page 49

3.       We note your revised disclosure in response to previous comment 12 and
re-issue the
         comment in part. We refer to your disclosure that you "do not expect
the timing or success
         of the Klydon acquisition to have a material effect on either our
business or our financial
         results in the future because of the existing commercial agreements
(including exclusive
         licenses) that we have with Klydon." Please expand on this disclosure
to explain why your
         existing commercial agreements with Klydon would prevent the
acquisition of Klydon
         from having a material effect on your business. In this regard, we
note your statement on
         page 25 that your are "substantially dependent on the Turnkey Contract
for the operation
         of [y]our company" because you do not yet have sufficient internal
capabilities to perform
         the functions Klydon is providing under such agreement. Please discuss
any material risks
         that would be associated with having to directly develop, manage
and/or finance the
         services Klydon is providing under the existing commercial agreements
in the event that
         you were to acquire Klydon.
Continue identifying potential offtake customers and strategic partners for
Mo-100, page 59

4.       We note your response to previous comment 18 regarding the name of the
strategic
         advisor in China. Please expand on your disclosure to explain that you
expect to enter into
         similar consulting and sales commission agreements with other
individuals and entities in
         the future in the ordinary course of business.
Indemnification Arrangements with Drs Ronander and Strydom, page 90

5.       We note your revised disclosure in response to previous comment 24 and
re-issue the
         comment in part. Please describe any agreements that a third party
entered into with Dr
         Einar, Dr Strydom, Klydon, and Isotope Separation Technology (Pty)
Ltd. that would be
         covered by this indemnification agreement. Additionally, please
disclose whether you are
         aware of any instituted or threatened claim, litigation or controversy
which could be
         covered by the indemnification agreement. Finally, please disclose
whether
         Klydon, Isotope Separation Technology (Pty) Ltd, or any other third
party is providing
         indemnity against these claims as well.
Advisor Agreement with ChemBridges LLC, page 91

6.       We note your revised disclosure in response to previous comment 34.
Please revise your
         description of the Advisor Agreement with ChemBridges LLC to describe
the termination
         provisions of such agreement.

         You may contact Ibolya Ignat at 202-551-3636 or Kevin Kuhar at
202-551-3662 if you
 Paul Mann
ASP Isotopes Inc.
July 12, 2022
Page 3

have questions regarding comments on the financial statements and related
matters. Please
contact Conlon Danberg at 202-551-4466 or Christopher Edwards at 202-551-6761
with any
other questions.



                                                         Sincerely,
FirstName LastNamePaul Mann
                                                         Division of
Corporation Finance
Comapany NameASP Isotopes Inc.
                                                         Office of Life
Sciences
July 12, 2022 Page 3
cc:       Mr. Donald Ainscow, Esq.
FirstName LastName