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                                September 9, 2022

       Jinfeng Huang
       Chairman of the Board of Directors and Chief Executive Officer
       Yatsen Holding Ltd
       Building No. 35, Art Port International Creation Center
       No. 2519 Xingang East Road, Haizhu District
       Guangzhou 510330
       People's Republic of China

                                                        Re: Yatsen Holding Ltd
                                                            Form 20-F for
Fiscal Year Ended December 31, 2021
                                                            Correspondence
filed July 25, 2022
                                                            File No. 001-39703

       Dear Mr. Huang:

              We have reviewed your response to our comment letter and have the
following
       comments. In some of our comments, we may ask you to provide us with
information so we
       may better understand your disclosure. Please respond to these comments
within ten business
       days by providing the requested information or advise us as soon as
possible when you will
       respond. If you do not believe our comments apply to your facts and
circumstances, please tell
       us why in your response. After reviewing your response to these
comments, we may have
       additional comments. Unless we note otherwise, our references to prior
comments are to
       comments in our June 7, 2022 letter.

       Correspondence filed July 25, 2022

       Item 3. Key Information, page 3

   1.                                                   Please disclose in
footnote (1) on page 4 that Mr. Huang is the Registrant's CEO and
                                                        controlling
shareholder. Similarly, please disclose this fact in the "potential conflicts
of
                                                        interest" risk factor
on page 46.
   2.                                                   In order to enhance the
reader's comprehension of the data provided, please add a
                                                        "WFOE" parenthetical
disclosure to the "Huizhi Weimei" box in the page 4 organizational
                                                        chart and to each
"Primary Beneficiary of VIE" column on pages 8-11.
   3.                                                   We note the footnote
disclosure on page 12 addressing certain intercompany accounts on
                                                        your consolidating
statements. Please expand this disclosure to describe the nature of the
                                                        intercompany amounts
between the VIE and WFOE, including how they originated and
                                                        how the amounts are
determined. Address the Exclusive Business Cooperation Agreement
 Jinfeng Huang
Yatsen Holding Ltd
September 9, 2022
Page 2
         and other contractual arrangements with the VIE and describe the
extent these
         arrangements result in intercompany payables and cash flows.
4.       Given that the Registrant is a holding company with no operations,
please describe for us
         the transactions that generated the 56,180 deferred income balance
presented on page 9. It
         appears that this transaction materially impacts the 2021 operating
cash flow surplus
         amount reported for Yatsen Holding Limited on page 11.
Our Holding Company Structure and Contractual..., page 3

5.       We note your response to prior comment one and reissue in part.
Regarding
         investor exposure to foreign investment in China-based companies,
please disclose that
         Chinese law prohibits direct foreign investment in the operating
companies.
General

6.       We note your response to prior comment 12 and reissue in part. Your
response explains
         that your operating metrics and all disclosures about
China/PRC-specific laws and
         regulations are not intended to include Hong Kong and Macau. Please
revise your future
         filings, as applicable, to clarify where appropriate that the legal
and operational risks
         associated with operating in China apply to your operations in Hong
Kong and, if
         applicable, Macau. Discuss commensurate laws and regulations in Hong
Kong, and if
         applicable Macau, and highlight any material risks or consequences to
the Company
         associated with those laws and regulations.
       You may contact Al Pavot at 202.551.3738 or Terence O'Brien at
202.551.3355 if you
have questions regarding comments on the financial statements and related
matters. Please
contact Doris Stacey Gama at 202.551.3188 or Joe McCann at 202.551.6262 with
any other
questions.



FirstName LastNameJinfeng Huang                               Sincerely,
Comapany NameYatsen Holding Ltd
                                                              Division of
Corporation Finance
September 9, 2022 Page 2                                      Office of Life
Sciences
FirstName LastName