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                              October 20, 2022

       Janet H. Zelenka
       Executive Vice President and Chief Financial Officer
       Stericycle, Inc.
       2355 Waukegan Road
       Bannockburn, IL 60015

                                                        Re: Stericycle, Inc.
                                                            Form 10-K for
Fiscal Year Ended December 31, 2021
                                                            Response dated
October 3, 2022
                                                            File No. 001-37556

       Dear Janet H. Zelenka:

              We have reviewed your October 3, 2022 response to our comment
letter and have the
       following comments. In some of our comments, we may ask you to provide
us with information
       so we may better understand your disclosure.

              Please respond to these comments within ten business days by
providing the requested
       information or advise us as soon as possible when you will respond. If
you do not believe our
       comments apply to your facts and circumstances, please tell us why in
your response.

             After reviewing your response to these comments, we may have
additional
       comments. Unless we note otherwise, our references to prior comments are
to comments in our
       September 12, 2022 letter.

       Response dated October 3, 2022

       Risk Factors, page 20

   1.                                                   We note your response
to prior comment 1 indicating that technology risks are
                                                        disclosed in a risk
factor relating to competition and your response stating that the new or
                                                        alternative
technologies employed by competitors "may include technologies intended to
                                                        reduce the carbon
emissions attributable to the services offered by the Company and its
                                                        competitors."
Consistent with our prior comment, please revise your disclosure to
                                                        specifically address
the impact that climate change related technological
                                                        developments may have
on your operations and business.
 Janet H. Zelenka
FirstName
Stericycle, LastNameJanet H. Zelenka
            Inc.
Comapany
October  20,NameStericycle,
             2022           Inc.
October
Page  2 20, 2022 Page 2
FirstName LastName
       Please contact Anuja A. Majmudar, Attorney-Adviser, at (202) 551-3844 or
Karina
Dorin, Attorney-Adviser, at (202) 551-3763 with any questions.



                                                         Sincerely,

                                                         Division of
Corporation Finance
                                                         Office of Energy &
Transportation