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                              November 3, 2022

       Paul Mann
       Chairman, Chief Executive Officer and Chief Financial Officer
       ASP Isotopes Inc.
       433 Plaza Real, Suite 275
       Boca Raton, Florida 33432

                                                        Re: ASP Isotopes Inc.
                                                            Amendment No. 3 to
Registration Statement on Form S-1
                                                            Filed October 31,
2022
                                                            File No. 333-267392

       Dear Paul Mann:

             We have reviewed your amended registration statement and have the
following
       comments. In some of our comments, we may ask you to provide us with
information so we
       may better understand your disclosure.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comments apply to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to these comments, we may have additional comments.

       Amendment No. 3 to Registation Statement on Form S-1, Filed October 31,
2022

       Summary
       Recent Developments, page 3

   1.                                                   We note your statement
on page 3: "if the licensed rights granted to us are found to be
                                                        invalid or
unenforceable, or if our exclusive license agreement with Klydon is terminated
                                                        or Klydon, as licensor,
fails to abide by the terms of our exclusive license agreement, our
                                                        ability to
commercialize our future isotopes would suffer and our business, results of
                                                        operations and
financial condition may be adversely affected." Please revise to clarify
                                                        what your business
operations would be if you did not have this license, given your
                                                        current and proposed
business seems to operate either exclusively or mostly through use
                                                        of the ASP technology.
 Paul Mann
ASP Isotopes Inc.
November 3, 2022
Page 2
2.    We note your statement on page 3 that "[t]he NMS Letter includes a
request for ASP
      Isotopes Inc. to enter into discussions for an agreement with NMS based
on terms
      proposed in previous correspondence from NMS." Please revise to provide a
high level
      summary of the terms of the previous correspondence with NMS.
       You may contact Ibolya Ignat at 202-551-3636 or Kevin Kuhar at
202-551-3662 if you
have questions regarding comments on the financial statements and related
matters. Please
contact Jordan Nimitz at 202-551-5831 or Margaret Schwartz at 202-551-7153 with
any other
questions.



                                                         Sincerely,

FirstName LastNamePaul Mann                              Division of
Corporation Finance
                                                         Office of Industrial
Applications and
Comapany NameASP Isotopes Inc.
                                                         Services
November 3, 2022 Page 2
cc:       Brenda Hamilton, Esq.
FirstName LastName