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                               November 8, 2022

       Paul Mann
       Chairman, Chief Executive Officer and Chief Financial Officer
       ASP Isotopes Inc.
       433 Plaza Real, Suite 275
       Boca Raton, Florida 33432

                                                        Re: ASP Isotopes Inc.
                                                            Amendment No. 4 to
Registration Statement on Form S-1
                                                            Filed November 4,
2022
                                                            File No. 333-267392

       Dear Paul Mann:

              We have reviewed your amended registration statement and have the
following
       comment. In our comment, we may ask you to provide us with information
so we may better
       understand your disclosure.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comment applies to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to this comment, we may have additional comments.

       Amendment No. 4 to Form S-1 filed November 4, 2022

       Risk Factors
       Risks Related to This Offering and Ownership of Our Common Stock
       The price of our stock may be volatile, and you could lose all or part
of your investment, page 33

   1.                                                   We note recent
instances of extreme stock price run-ups followed by rapid price declines
                                                        and stock price
volatility seemingly unrelated to company performance following a
                                                        number of recent
initial public offerings, particularly among companies with relatively
                                                        smaller public floats.
Please revise your risk factor to clearly state that such volatility,
                                                        including any stock
run-up, may be unrelated to both your actual and expected operating
                                                        performance and
financial condition or prospects, making it difficult for prospective
                                                        investors to assess the
rapidly changing value of your stock.
 Paul Mann
ASP Isotopes Inc.
November 8, 2022
Page 2

      You may contact Brian Cascio at 202-551-3676 if you have questions
regarding
comments on the financial statements and related matters. Please contact Jordan
Nimitz at 202-
551-5831 or Margaret Schwartz at 202-551-7153 with any other questions.



                                                           Sincerely,

FirstName LastNamePaul Mann                                Division of
Corporation Finance
                                                           Office of Industrial
Applications and
Comapany NameASP Isotopes Inc.
                                                           Services
November 8, 2022 Page 2
cc:       Brenda Hamilton, Esq.
FirstName LastName